Customer Publications (A total of 2946 papers published)

Preclinical Safety of a 3D-Printed Hydroxyapatite-Demineralized Bone Matrix Scaffold for Spinal Fusion

M Plantz, J Lyons, JT Yamaguchi, AC Greene, DJ Ellenbogen, MJ Hallman, V Shah, C Yun, AE Jakus, D Procissi, S Minardi, RN Shah, WK Hsu, EL Hsu

Spine (ingentaconnect) USA, 01 January 2022

Osteology

Key words: 3D Printing, Bone Morphogenetic Protein-2, Demineralized Bone Matrix, Host Inflammatory Response, Hydroxyapatite, Spinal Fusion [more]

Detection of Cytopathic Effects Induced by Influenza, Parainfluenza, and Enterovirus Using Deep Convolution Neural Network

JJ Chen, PH Lin, YY Lin, KY Pu, CF Wang, SY Lin, TS Chen

Biomedicines (MDPI) Taiwan, 28 December 2021

Machine Learning, Virology

Key words: Artificial Intelligence, Cytopathic Effect, ResNet-50

The liquid Kangfuxin (KFX) has efficient antifungal activity and can be used in the treatment of vulvovaginal candidiasis in mouse

J Ma, YC Yang, LQ Su, DM Qin, K Yuan, Y Zhang, RR Wang

Letters in Applied Microbiology (Wiley) China, 27 December 2021

Infectious Diseases, Reproductive Medicine

Key words: Candida Albicans, Kangfuxin Liquid, Antifungal, Vaginal Candidiasis, Murine Model [more]

Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

CY Chang, KY Chen, HJ Shih, M Chiang, IT Huang, YH Huang, CJ Huang

Pharmaceuticals (MDPI) Taiwan, 27 December 2021

Endocrinology

Key words: Obesity, Sepsis, Liver, Exosomes, let-7i [more]

Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis

J Zhang, L Wang, C Li, H Zhang, R Li, M Li

Systems biology in Reproductive Medicine (Taylor & Francis) China, 27 December 2021

Reproductive Medicine

Key words: Letrozole, Endometriosis, Endometrial Receptivity, Integrin avβ3, HOXA10 [more]

Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells

K Piatek, A Kutner, D Cacsire Castillo-Tong, T Manhardt, N Kupper, U Nowak, M Chodyński, E Marcinkowska, E Kallay, M Schepelmann

International Journal of Molecular Sciences (MDPI) Austria, Poland, 24 December 2021

Endocrinology, Oncology

Key words: Vitamin D, Vitamin D Analogs, 25 Vitamin D 24-Hydroxylase, CYP24A1, Proliferation, High-Grade Serous Ovarian Cancer Cells [more]

Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression

YH Chu, WC Liao, YJ Ho, CH Huang, TJ Tseng, CH Liu

Cells (MDPI) Taiwan, 20 December 2021

Oncology

Key words: Glioma, Chondroitin Sulfate, CHSY1, Integrin Β1, CD44, Therapeutic Peptide

S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 MAPK Pathways

K Tanigawa, S Tsukamoto, Y Koma, Y Kitamura, S Urakami, M Shimizu, M Fujikawa, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki

The American Journal of Pathology (Elsevier) Japan, 20 December 2021

Oncology

[more]

Spatial point pattern analysis identifies mechanisms shaping the skin parasite landscape in Leishmania donovani infection

JSP Doehl, H Ashwin, N Brown, A Romano, S Carmichael, JW Pitchford, PM Kaye

Frontiers in Immunology (Frontiers Media S.A.) UK, 16 December 2021

Parasitology

Key words: Leishmania donovani, host cell, dispersion, dispersal, skin patches, spatial point pattern analysis [more]

P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease

Y Li, H Zhang, J Yang, M Zhan, X Hu, Y Liu, L Yu, X Yan, S Liang, R Zhang, Y Lu, B Li, C Liu, M Li

Chinese Medicine (Springer) China, 16 December 2021

Gastroenterology

Key words: P2Y12 Receptor, Visceral Pain, Depression, EA, IBD [more]

Hedgehog-signalling in papillary fibroblasts is essential for hair follicle regeneration during wound healing

S Frech, A Forsthuber, A Korosec, K Lipp, V Kozumov, BM Lichtenberger

Journal of Investigative Dermatology (Elsevier) Austria, 16 December 2021

Dermatology

Key words: Wound Healing, Dermal Fibroblast Lineages, Hedgehog Signaling, Hair Follicle Neogenesis, WIHN, Papillary and Reticular Fibroblasts, Regeneration [more]

Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma

C Wang, Y Huang, X Ma, B Wang, X Zhang

International Journal of Immunpathology and Pharmacology (SAGE Journals) China, 15 December 2021

Oncology

Key words: Clear Cell Renal Cell Carcinoma, NEK2, Prognosis [more]

CD163+ M2 macrophages promote fibrosis in IgG4‐related disease via TLR7/IRAK4/NF‐κB signaling

A Chinju, M Moriyama, N Kakizoe-Ishiguro, H Chen,Y Miyahara, AR Haque, K Furusho, M Sakamoto, K Kai, K Kibe, S Hatakeyama-Furukawa, M Ito-Ohta, T Maehara, S Nakamura

Arthritis & Rheumatology (Wiley) Japan, Bangladesh, 15 December 2021

Immunology, Rheumatology

Key words: Igg4-Related Disease, M2 Macrophage, Toll-Like Receptor 7, IL-1 Receptor-Associated Kinase 4, Fibrosis [more]

Nuplazid suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting PAK4

Y Wei, W Wu, Y Jiang, H Zhou, Y Yu, L Zhao, X Wu, X Lu, Q Yuan, Z Wang, Z Dong, L He, J Zhao, K Liu

British Journal of Cancer (Nature) China, 15 December 2021

Oncology

Key words: Cancer Prevention [more]

A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice

K Cao, X Wang, H Peng, L Ding, X Wang, Y Hu, L Dong, T Yang, X Hong, M Xing, D Li, C Zhu, X He, C Zhao, P Zhao, D Zhou, X Zhang, J Xu

Journal of Virology (American Society for Microbiology) China, 15 December 2021

SARS-CoV-2

Key words: COVID-19, Vaccine, SARS-CoV-2 Variants, Influenza, Adenoviral Vector [more]

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development

T Wang, J Zhang, N Li, M Li, S Ma, S Tan, X Guo, Z Wang, Z Wu, L Gao, C Ma, X Liang

Molecular Therapy (Cell Press) China, 15 December 2021

Oncology

Key words: Tim-3, Tim-3 Ligands, Immune Checkpoint Blockade, Tumor Microenvironment, Multiplexed Immunofluorescence [more]

Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response

YT Yen, M Chien, PY Wu, CC Ho, CT Ho, KCY Huang, SF Chiang, KSC Chau, WTL Chen, SC Hung

Nature Communications (Nature) Taiwan, 15 December 2021

Oncology, Immunology

Key words: Cancer Immunotherapy, Colon Cancer, Gene Silencing, Immunoediting [more]

Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

J Chen, J Fan, Z Chen, M Zhang, H Peng, J Liu, L Ding, M Liu, C Zhao, P Zhao, S Zhang, X Zhang, J Xu

PNAS (United States National Academy of Sciences) China, 14 December 2021

SARS-CoV-2

[more]

Polypharmacological reprogramming of tumor-associated macrophages towards an inflammatory phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR Publications) USA, 13 December 2021

Oncology

Key words: Tumor-Associated Macrophage, Breast Cancer, Tumor Microenvironment, Kinase Inhibitor Screening, Cell-Cell Interaction [more]

The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model

A Kannan, S Minardi, DJ Ellenbogen, MJ Hallman, AC Greene, JT Yamaguchi, MA Plantz, S Jeong, KC Sana, V Shah, C Yun, EL Hsu, WK Hsu

JOR Spine (Wiley) USA, 13 December 2021

Rheumatology

Key words: Local Steroid, Osteogenesis, Pseudarthrosis, Spine Fusion [more]

The plasminogen receptor Plg‐RKT regulates adipose function and metabolic homeostasis

F Samad, H Bai, N Baik, P Haider, Y Zhang, G Rega-Kaun, C Kaun, M Prager, J Wojta, Q Bui, S Chakrabarty, J Wang, RJ Parmer, LA Miles

Journal of Thrombosis and Haemostasis (Wiley) USA, Austria, 12 December 2021

Endocrinology

Key words: Adipose Inflammation, Hepatic Steatosis, Insulin Resistance, Obesity, Plg-RKT [more]

Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension

Z Zhao, Z Guo, Z Yin, Y Qiu, B Zhou

Frontiers in Physiology (Frontiers Media S.A.) China, 10 December 2021

Gastroenterology

Key words: Intra-Abdominal Hypertension, Abdominal Compartment Syndrome, Fecal Microbiota Transplantation, 16S rRNA, Gut Microbiota Dysbiosis [more]

FGL1 as a Novel Mediator and Biomarker of Malignant Progression in Clear Cell Renal Cell Carcinoma.

Z Lv, B Cui, X Huang, HY Feng, T Wang, HF Wang, YD Xuan, HZ Li, X Ma, Y Huang, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 09 December 2021

Oncology

Key words: biomarker, clear cell renal cell carcinoma, epithelial to mesenchymal transition, fibrinogen-like protein 1, progression [more]

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

T Zhang, L Sun, Y Hao, C Suo, S Shen, H Wei, W Ma, P Zhang, T Wang, X Gu, ST Li, Z Chen, R Yan, Y Zhang, Y Cai, R Zhou, W Jia, F Huang, P Gao, H Zhang

Nature Cancer (Nature) China, 09 December 2021

Oncology

[more]

CD146 as a Prognostic-Related Biomarker in ccRCC Correlating With Immune Infiltrates

Z Lv, HY Feng, W Tao, HZ Li, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 08 December 2021

Oncology

Key words: CD146, ccRCC, prognosis, methylation, tumor microenvironment [more]

Lipid Droplet-Specific Probe for Rapidly Locating Atherosclerotic Plaques and Intraoperative Imaging via In Situ Spraying

M Sang, B Cai, S Qin, S Zhao, Y Mao, Y Wang, X Yu, J Zheng

ACS Applied Materials & Interfaces (ACS Publications) China, 06 December 2021

Biological Methods

Key words: Lipids, Liquids, Fluorescence, Fluorescence Imaging, Probes [more]

Hedgehog signaling controls bone homeostasis by regulating osteogenic/adipogenic fate of skeletal stem/progenitor cells in mice

L Zhang, X Fu, L Ni, C Liu, Y Zheng, H You, M Li, C Xiu, L Zhang, T Gong, N Luo, Z Zhang, G He, S Hu, H Yang, D Chen, J Chen

Journal of Bone and Mineral Research (Wiley) China, 06 December 2021

Osteology, Stem Cell Research

Key words: Genetic Animal Models, Hedgehogs, Stromal/Stem Cells, Osteoporosis, Aging [more]

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

JL Zhang, YH Li, LL Wang, HQ Liu, SY Lu, Y Liu, K Li, B Liu, SY Li, FM Shao, K Wang, N Sheng, R Li, JJ Cui, PC Sun, CX Ma, B Zhu, Z Wang, YH Wan, SS Yu, Y Che, CY Wang, C Wang, Q Zhang, LM Zhao, XZ Peng, Z Cheng, JB Chang, JD Jiang

Signal Transduction and Targeted Therapy (Nature) China, 06 December 2021

SARS-CoV-2

Key words: Drug Development, Infectious Diseases [more]

Ascorbic acid-2 glucoside mitigates intestinal damage during pelvic radiotherapy in a rat bladder tumor model

Y Ito, T Yamamoto, K Miyai, J Take, H Scherthan, A Rommel, S Eder, K Steinestel, A Rump, M Port, N Shinomiya, M Kinoshita

International Journal of Radiation Biology (Taylor & Francis) Japan, Germany, 06 December 2021

Oncology, Radiotherapy

Key words: AY-27 Cells, DNA Damage, 53BP1, CD163, M1/M2, Macrophages [more]

Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration

M Zou, L Gong, Q Ke, R Qi, X Zhu, W Liu, Q Sun, X Tang, Z Luo, X Gong, Y Liu, DWC Li

Free Radical Biology and Medicine (Elsevier) China, 04 December 2021

Cell Biology

Key words: Age-Related Macular Degeneration, Heterochromatin, Inflammation, Methotrexate, cGAS, STING [more]

Defect of LSS Disrupts Lens Development in Cataractogenesis.

M Zhao, T Mei, B Shang, B Zou, Q Lian, W Xu, K Wu, Y Lai, C Liu, L Wei, J Zhu, K Zhang, Y Liu, L Zhao

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 02 December 2021

Developmental Biology

Key words: lanosterol synthase, congenital cataract, mouse model, mutation, lens development [more]

Mad2 Induced Aneuploidy Contributes to Eml4-Alk Driven Lung Cancer by Generating an Immunosuppressive Environment

K Alikhanyan, Y Chen, K Somogyi, S Kraut, R Sotillo

Cancers (MDPI) Germany, 30 November 2021

Oncology

Key words: Lung Cancer, Aneuploidy, Tumor Microenvironment, Immune Suppression, Mouse Models [more]

Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1

A Lo, K Holmes, S Kamlapurkar, F Mundt, S Moorthi, I Fung, S Fereshetian, J Watson, SA Carr, P Mertins, AH Berger

Science Signaling (Science) USA, 30 November 2021

Oncology

[more]

Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy

A Dodd, AA Natfji, A Evangelinos, A Grigoletto, G Pasut, F Beards, L Renshall, HMI Osborn, F Greco, LK Harris

Molecular Pharmaceutics (ACS Publications) UK, Italy, 29 November 2021

Pharmacology

Key words: Polymer−Drug Conjugate PEG Pregnancy Placenta Transport Drug Delivery [more]

ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

VA Arrieta, AX Chen, JR Kane, SJ Kang, C Kassab, C Dmello, J Zhao, KB Burdett, PS Upadhyayula, C Lee-Chang, J Shilati, D Jaishankar, L Chen, A Gould, D Zhang, J Yuan, W Zhao, X Ling, JK Burks, B Laffleur, C Amidei, JN Bruce, RV Lukas, JT Yamaguchi, D Cieremans, G Rothschild, U Basu, M McCord, DJ Brat, H Zhang, LAD Cooper, B Zhang, P Sims, TF Cloughesy, R Prins, P Canoll, R Stupp, AB Heimberger, C Horbinski, FM Iwamoto, R Rabadan, AM Sonabend

Nature Cancer (Nature) USA, Mexico, France, 29 November 2021

Oncology

Key words: Cancer, Cancer Immunotherapy, CNS Cancer, Tumour Biomarkers [more]

Single cell imaging-based chromatin biomarkers for tumor progression

S Venkatachalapathy, DS Jokhun, M Andhari, GV Shivashankar

Scientific Reports (Nature) Singapore, India, Italy, Switzerland, 29 November 2021

Oncology

Key words: Biomarkers, Biophysics, Cancer, Computational Biology and Bioinformatics [more]

Lipid‐Activatable Fluorescent Probe for Intraoperative Imaging of Atherosclerotic Plaque Using In Situ Patch

J Zheng, S Zhao, Y Mao, Z Du, G Li, M Sang

Nano Micro Small (Wiley) China, 27 November 2021

Biological Methods

[more]

HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

C Da, J Pu, Z Liu, J Wei, Y Qu, Y Wu, B Shi, J Yang, N He, P Hou

Signal Transduction and Targeted Therapy (Nature) China, 24 November 2021

Oncology

Key words: Cancer, Molecular Biology [more]

Mechanism of Chronic Stress-Induced Glutamatergic Neuronal Damage in the Basolateral Amygdaloid Nucleus

S Wang, X Liu, W Shi, Q Qi, G Zhang, Y Li, B Cong, M Zuo

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 23 November 2021

Neuroscience

[more]

Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

C Wang, A Cui, M Bukenya, A Aung, D Pradhan, CA Whittaker, Y Agarwal, A Thomas, S Liang, P Amlashi, H Suh, S Spranger, N Hacohen, DJ Irvine

Cell Reports (Cell Press) USA, 23 November 2021

Immunology, Oncology

Key words: NK Cell, Macrophage, Checkpoint Blockade, Sensitization, Tumor-Targeting Antibody, Interleukin-2, Tumor Microenvironment, Vascular Normalization [more]

Pectins from various sources inhibit galectin-3-related cardiac fibrosis

AR van der Velde, WC Meijers, HHW Silljé, P Muntendam, MM Dokter, WH van Gilst, HA Schols, RA de Boer

Current Research in Translational Medicine (Elsevier) USA, The Netherlands, 23 November 2021

Cardiology

Key words: Galectin-3, Inhibitor, Pectin, Heart failure, Fibrosis, Affinity [more]

CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c. 1085 Genotypes

YM Yeh, PC Lin, WC Su, MR Shen

International Journal of Molecular Sciences (MDPI) Taiwan, 22 November 2021

Oncology

Key words: Colony-Stimulating Factor 1 Receptor, Genetic Variant, CD40, IL-2 Expression, Colorectal Cancer [more]

Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds

WH Tsai, CH Chou, TY Huang, HL Wang, PJ Chien, WW Chang, HT Lee

Cells (MDPI) Taiwan, 22 November 2021

Dermatology

Key words: Heat-Killed Probiotics, Lactobacillus, L. Plantarum, L. Paracasei, Skin Wound Healing, Lipoteichoic Acid [more]

Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin-and mucosa-resident memory T cells

S Saluzzo, RV Pandey, LM Gail, R Dingelmaier-Hovorka, L Kleissl, L Shaw, B Reininger, D Atzmüller, J Strobl, V Tonzeau-Römer, A Beer, C Staud, A Rieger, M Farlik, W Weninger, G Stingl, G Stary

Immunity (Cell Press) Austria, 22 November 2021

Immunology, Virology

Key words: HIV, Tissue-Resident Memory T Cells, Skin, Mucosal Immunity, HPV, Cancer, CXCR3 [more]

BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression

Q Wu, F Liu, M Ge, KV Laster, L Wei, R Du, M Jiang, J Zhang, Y Zhi, G Jin, S Zhao, DJ Kim, Z Dong, K Liu

Oncogene (Nature) China, 19 November 2021

Oncology

Key words: Oncogenes, Transcription [more]

Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca2+ channels through BAG3

R Wang, M Wang, B Liu, H Xu, J Ye, X Sun, G Sun

Biomedicine & Pharmacotherapy (Elsevier) China, 17 November 2021

Cardiology

Key words: calenduloside E, myocardial ischemia-reperfusion injury, L-type Ca2+ channels, BAG3, calcium overload, autophagy [more]

Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy

M Gao, Y Chen, C Wu

Bioengineered (Taylor & Francis) China, 16 November 2021

Nanomedicine, Oncology

Key words: Malignant Glioma, Doxorubicin-Loaded Nanoparticles, Chemosensitization, Tumor Chemotherapy, Size-Dependent [more]

HSBP1 Is a Novel Interactor of FIP200 and ATG13 That Promotes Autophagy Initiation and Picornavirus Replication

M Mauthe, N Dinesh Kumar, P Verlhac, N van de Beek, F Reggiori

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) The Netherlands, 15 November 2021

Virology

Key words: Autophagy, Infection, ULK Kinase Complex, EMCV, CVB3, EV71 [more]

Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells

KC Wei, YC Lin, CH Chen, YH Chu, CY Huang, WC Liao, CH Liu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, 15 November 2021

Oncology

Key words: Fucosyltransferase 8, Glioma, HGF, MET, EGFR [more]

Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

LC Wang, WY Wei, PC Ho, PY Wu, YP Chu, KJ Tsai

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 12 November 2021

Neuroscience

Key words: Cortical Electrical Stimulation, Neuromodulation, Ischemic Stroke, BDNF, PI3K – PKB/Akt Signaling Pathway [more]

TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma

EY Lee, M Kim, BK Choi, DH Kim, I Choi, HJ You

Molecules and Cells (Korean Society for Molecular and Cellular Biology) South Korea, 12 November 2021

Oncology

Key words: cytokines, leiomyosarcoma, tjp1, tumor microenvironment [more]

Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

AE Hinman, C Jani, SC Pringle, WR Zhang, N Jain, AJ Martinot, AK Barczak

eLife (eLife Sciences Publications) USA, 10 November 2021

Immunology, Microbiology

[more]

Dopamine D2 receptor regulates cortical synaptic pruning in rodents

YQ Zhang, WP Lin, LP Huang, B Zhao, CC Zhang, DM Yin

Nature Communications (Nature) China, 08 November 2021

Neuroscience

Key words: Diseases of The Nervous System, Molecular Neuroscience, Spine Regulation and Structure, Synaptic Development [more]

IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1

WJ Wu, SH Wang, CC Wu, YA Su, CY Chiang, CH Lai, TH Wang, TL Cheng, JY Kuo, TC Hsu, TH Lin, YJ Lee

International Journal of Molecular Sciences (MDPI) Taiwan, 05 November 2021

Reproductive Medicine

Key words: IL-4, IL-13, Mammary Glands, Cell Proliferation, STAT6, IRS Protein [more]

Donor Bone Marrow Derived Macrophage Engraftment into the Central Nervous System of Allogeneic Transplant Patients

AM Loeb, SS Pattwell, A Bedalov, S Meshinchi, KR Loeb

Blood (ASH Publications) USA, 05 November 2021

Hematology

[more]

Cholesterol-lowering Intervention Decreases mTOR Complex 2 Signaling and Enhanced Antitumor Immunity

Y Wang, S You, S Su, A Yeon, E Lo, S Kim, J Mohler, MR Freeman, HL Kim

Clinical Cancer Research (AACR Publications) USA, 02 November 2021

Oncology

[more]

Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

RJ Ni, YM Shu, T Li, JN Zhou

Frontiers in Neuroanatomy (Frontiers Media S.A.) China, 02 November 2021

Neuroscience

Key words: Caudate Nucleus, Putamen, Accumbens Nucleus, Thalamus, Neural Circuits [more]

Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals

S Fischer, E Nasyrov, M Brosien, KT Preissner, HM Marti, R Kunze

Journal of Neuroinflammation (BMC) Germany, 02 November 2021

Neuroscience

Key words: Extracellular RNA, Astrocyte, Inflammation, Stroke, Ischemia/Reperfusion, PAMP, DAMP, TLR [more]

Expression of Vascular Cell Adhesion Molecule-1 in Peripheral Artery Disease is Enriched in Patients with Advanced Kidney Disease

PT Lee, IC Liao, CH Lee, LW Hsu, PY Liu

Acta Cardiologica Sinica (Taiwan Society of Cardiology) Taiwan, 01 November 2021

Cardiology

Key words: Chronic Kidney Disease, Hemodialysis [more]

SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway

CY Kuo, YC Chang, MN Chien,

Endocrine-Related Cancer (Society for Endocrinology) Taiwan, 01 November 2021

Oncology

Key words: SREBP1, Invasion, Thyroid Cancer, Lipid Metabolism [more]

Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer

BL Horton, DM Morgan, N Momin, M Zagorulya, E Torres-Mejia, V Bhandarkar, KD Wittrup, JC Love, S Spranger

Science Immunology (Science) USA, 29 October 2021

Oncology, Immunology

[more]

Spatiotemporal Protein Expression Profiles of QSOX1 in the Murine Uterus, Placenta, and Embryo during Pregnancy

HS Lin, RKK Lee, TH Yang, HW Fang, SH Li

Applied Sciences (MDPI) Taiwan, 29 October 2021

Reproductive Medicine

Key words: Quiescin Sulfhydryl Oxidase 1, Uterus, Placenta, Embryo, Maternal-Fetal Interface, Tissue Distribution, Pregnancy [more]

SPION NANOPARTICLES IN VITRO AND IN VIVOTESTING FOR ANTIMELANOMA DRUG RELEASE INTO TUMORS

M Doni, HF Oancea, HRC Fierăscu

The International Symposium PRIOrities of CHEMistry for a sustainable development (ICECHIM) Romania, 29 October 2021

Oncology, Nanomedicine

Key words: melanoma cells, syngeneic melanoma mouse model, drug delivery, IHC, RT-qPCR [more]

Carboxypeptidase N1 is anticipated to be a synergy metrics for chemotherapy effectiveness and prognostic significance in invasive breast cancer

YY Fan, CH Liu, AL Wu, HC Chen, YJ Hsueh, KJ Chen, CC Lai, CY Huang, WC Wu

Cancer Cell International (Springer) China, 28 October 2021

Oncology

Key words: Carboxypeptidase N1, CA153, Chemotherapeutic Efficacy, Prognosis, Invasive Breast Cancer [more]

Increased osteogenic activity of dynamic cultured composite bone scaffolds: Characterization and in vitro study

ML Mueller, MP Ottensmeyer, JR Thamm, R Schmelzeisen, MJ Troulis, FPS Guastaldi

Journal of Oral and Maxillofacial Surgery (Elsevier) USA, Germany, 27 October 2021

Osteology

Key words: Scaffolds, Bone Tissue Engineering, Calcium Phosphate, 3D Printing, ALP [more]

Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer

PF Yueh, YH Lee, I Chiang, WT Chen, KL Lan, CH Chen, FT Hsu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, USA, 26 October 2021

Oncology

Key words: Imipramine, Non-Small Cell Lung Cancer (NSCLC), EGFR - Epidermal Growth Factor Receptor, PKC-δ-Protein Kinase C Delta, NF-κB – Nuclear Factor Kappa B [more]

The prognostic value of TCF1+ CD8+ T in primary small cell carcinoma of the esophagus

L Ma, L Sun, K Zhao, Z Dong, Z Huang, X Meng

Cancer Science (Japanese Cancer Association) China, 25 October 2021

Oncology

Key words: prognosis, PSCCE, stem‐like, TCF1, tumor microenvironment [more]

Metabolic memory underlying minimal residual disease in breast cancer

K Radic Shechter, E Kafkia, K Zirngibl, S Gawrzak, A Alladin, D Machado, C Lüchtenborg, DC Sevin, B Brügger, KR Patil, M Jechlinger

Molecular Systems Biology (EMBO press) Germany, UK, 25 October 2021

Oncology

[more]

Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction

LJ Renshall, F Beards, A Evangelinos, SL Greenwood, P Brownbill, A Stevens, CP Sibley, JD Aplin, ED Johnstone, T Teesalu, LK Harris

Pharmaceutics (MDPI) UK, USA, 25 October 2021

Reproductive Medicine

Key words: Placenta, Pregnancy, Fetal Growth Restriction, LLiposomes, Epidermal Growth Factor [more]

Cardiac Fibrosis Is a Risk Factor for Severe COVID-19

J Mustroph, J Hupf, MJ Baier, K Evert, C Brochhausen, K Broeker, C Meindl, B Seither, C Jungbauer, M Evert, LS Maier, S Wagner

Frontiers in Immunology (Frontiers Media S.A.) Germany, 22 October 2021

SARS-CoV-2

Key words: SARS-CoV-2, COVID-19, Fibrosis, Heart, TGF-β1, NRP-1 [more]

Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist

H Mei, Z Zha, W Wang, Y Xie, Y Huang, W Li, D Wei, X Zhang, J Qu, J Liu

Genome Biology (BMC) China, 22 October 2021

Genetics

Key words: CRISPR, Genome-wide screen, Surfaceome screen, Rhinovirus, OLFML3 [more]

Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

C Shen, R Li, R Negro, J Cheng, SM Vora, TM Fu, A Wang, K He, L Andreeva, P Gao, Z Tian, RA Flavell, S Zhu, H Wu

CELL (Cell Press) USA, China, Italy, 21 October 2021

Immunology, Virology

Key words: NLRP6, dsRNA, Liquid-Liquid Phase Separation, LLPS, Inflammasome, MHV, RV, IDRs [more]

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

C Vinel, G Rosser, L Guglielmi, M Constantinou, N Pomella, X Zhang, JR Boot, TA Jones, TO Millner, AA Dumas, V Rakyan, J Rees, JL Thompson, J Vuononvirta, S Nadkarni, TE Assan, N Aley, YY Lin, P Liu, S Nelander, D Sheer, CLR Merry F Marelli-Berg, S Brandner, S Marino

Nature Communications (Nature) UK, Hong Kong, Sweden, 21 October 2021

Oncology

Key words: CNS Cancer, Reprogramming [more]

KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements

SM Zhang, WL Cai, X Liu, D Thakral, J Luo, LH Chan, MK McGeary, E Song, KRM Blenman, G Micevic, S Jessel, Y Zhang, M Yin, CJ Booth, LB Jilaveanu, W Damsky, M Sznol, HM Kluger, A Iwasaki, MW Bosenberg, Q Yan

Nature (Nature) USA, China, 20 October 2021

Oncology

Key words: Epigenetics, Melanoma [more]

A Recurrent STAT5BN642H Driver Mutation in Feline Alimentary T Cell Lymphoma

M Kieslinger, A Swoboda, N Kramer, P Freund, B Pratscher, HA Neubauer, R Steinborn, B Wolfesberer, A Fuchs-Baumgartinger, R Moriggl, IA Burener

Cancers (MDPI) Austria, 19 October 2021

Oncology

Key words: STAT5B, driver mutation, feline alimentary lymphoma, STAT3 [more]

Hippocampal and thalamic afferents form distinct synaptic microcircuits in the mouse infralimbic frontal cortex

K Graham, N Spruston, EB Bloss

Cell Reports (Cell Press) USA, 19 October 2021

Neuroscience

Key words: Frontal Cortex, circuit, Synapse, Interneuron, Projection neuron, rabies tracing, hippocampus, thalamus [more]

Autophagy Upregulates miR-449a Expression to Suppress Progression of Colorectal Cancer

SH Lan, SC Lin, WC Wang, YC Yang, JC Lee, PW Lin, ML Chu, KY Lan, R Zuchini, HS Liu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, 19 October 2021

Oncology

Key words: autophagy, miR-449a, FoxO1, colorectal cancer, tumorigenesis [more]

Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis

F Klemm, A Möckl, A Salamero-Boix, T Alekseeva, A Schäffer, M Schulz, K Niesel, RR Maas, M Groth, BT Elie, RL Bowman, ME Hegi, RT Daniel, PS Zeiner, J Zinke, PN Harter, KH Plate, JA Joyce, L Sevenich

Nature Cancer (Nature) Switzerland, Germany, USA, 18 October 2021

Oncology

Key words: Cancer, Cancer microenvironment, Cancer therapeutic resistance, Metastasis [more]

Recent progress in cytometric technologies and their applications in ecotoxicology and environmental risk assessment

D Wlodkowic, A Czerw, B Karakiewicz, A Deptala

Cytometry Part A (Wiley) Australia, Poland, 15 October 2021

Toxicology

An Integrated Bile Acids Profile Determination by UHPLC-MS/MS to Identify the Effect of Bile Acids Supplement in High Plant Protein Diet on Common Carp (Cyprinus carpio)

X Wei, T Yao, FN Fall, M Xue, X Liang, J Wang, W Du, X Gu

Foods (MDPI) China, 15 October 2021

Gastroenterology

Key words: Bile Acids, Common Carp, High Plant Protein Diet, Hepatopancreas, Glycogen Accumulation, UHPLC-MS/MS [more]

Siglec-15 Is an Immune Suppressor and Potential Target for Immunotherapy in the Pre-Metastatic Lymph Node of Colorectal Cancer

H Du, J Tang, X Li, X Wang, L Wu, R Zhang, P Hu, Y Yang

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 13 October 2021

Oncology

Key words: Pre-Metastatic Niche, Lymph Nodes, Colorectal Cancer, Immunosuppressive, SIGLEC15 [more]

LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure

CT Su, TM Jao, Z Urban, YJ Huang, DHW See, YC Tsai, WC Lin, JW Huang

Cell Death & Disease (Nature) Taiwan, 13 October 2021

Nephrology

Key words: Cell signalling, Pathogenesis [more]

Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation

J Strobl, LM Gail, L Kleissl, RV Pandey, V Smejkal, J Huber, V Puxkandl, L Unterluggauer, R Dindelmaier-Hovorka, D Atzmüller, T Krausgruber, C Bock, P Wohlfarth, W Rabitsch, G Stary

Journal of Experimental Medicine (Rockefeller University Press) Austria, 13 October 2021

Immunology

[more]

Sexual dimorphism in the bed nucleus of the stria terminalis, medial preoptic area and suprachiasmatic nucleus in male and female tree shrews

RJ Ni, YM Shu, PH Luo, JN Zhou

Journal of Anatomy (Wiley) China, 12 October 2021

Reproductive Medicine

[more]

Changes in expressions of spermatogenic marker genes and spermatogenic cell population caused by stress

P Tian, Z Zhao, Y Fan, N Cui, B Shi, G Hao

Frontiers in Endocrinology (Frontiers Media S.A.) China, 11 October 2021

Reproductive Medicine

Key words: Stress, Testis, Spermatogenesis, Gene, RNA Sequencing [more]

Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs

L Johnson Chacko, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudas, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fischer, A Zine

International Journal of Molecular Sciences (MDPI) USA, France, UK, Canada, 07 October 2021

Genetics

Key words: Human Induced Pluripotent Stem Cells, Otic Sensory Progenitors, Gene Expression Analysis, Extracellular Matrix, Integrins, Human Fetal Inner Ear [more]

Glucose/Glutathione Co-triggered Tumor Hypoxia Relief and Chemodynamic Therapy to Enhance Photothermal Therapy in Bladder Cancer

WH Chen, KJ Yu, JW Jhou, HH Pang, WH Wenig, WS Lin, HW Yang

ACS Applied Bio Materials (ACS Publications) Taiwan, 07 October 2021

Oncology, Pharmacology

Key words: Photothermal Therapy, Chemodynamic Therapy, Manganese Dioxide (MnO2), Tumor Hypoxia, Bladder Cancer [more]

Irreversible depletion of intestinal CD4+ T-cells is associated with T-cell activation during chronic HIV infection

OE Asowata, A Singh, A Ngoepe, N Herbert, R Faradoos, K Reddy, Y Zuingu, F Nene, N Mthabela, D Ramjit, K Govender, T Ndung'u, JZ Porterfield, JH Adamson, FG Madela, VT Manzini, F Anderson, A Leslie, HN Kløverpris

JCI Insight (American Society of Clinical Investigation) South Africa, Denmark, UK, Germany, USA, 07 October 2021

Immunology, Virology

[more]

Characterizing the host response to rhPDGF‐BB in a rat spinal arthrodesis model

JT Yamaguchi, JA Weiner, S Minardi, AC Greene, DJ Ellenbogen, MJ Hallman, VP Shah, KM Weisz, S Jeong, T Nandurkar, C Yun, WK Hsu, EL Hsu

JOR Spine (Wiley) USA, 07 October 2021

Osteology

[more]

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

B Wang, L Wang, NS Gasek, Y Zhou, T Kim, C Guo, ER Jellison, L Haynes, S Yadav, T Tchkonia, GA Kuchei, JL Kirkland, M Xu

Nature Aging (Nature) USA, China, 07 October 2021

Aging

Key words: Ageing, Animal biotechnology, Senescence

Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

H He, Q Liao, C Zhao, C Zhu, M Feng, Z Liu, L Jiang, L Zhang, X Ding, M Yuan, X Zhang, J Xu

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 06 October 2021

Oncology

[more]

Landscape of prognostic signatures and immunogenomics of the AXL/GAS6 axis in renal cell carcinoma

K Hakozaki, N Tanaka, K Takamatsu, R Takashi, Y Yasumizu, S Mikami, T Shinojima, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, R Mizuno, M Oya

British Journal of Cancer (Nature) Japan, 05 October 2021

Oncology

Key words: Renal Cell Carcinoma, Tumour Biomarkers [more]

NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression

J Liang, W Sun, H Song, C Wang, Q Li, C Li, D Wie, Y Zhao, C Li, H Zhang

Epigenomics (Future Medicine) China, 05 October 2021

Oncology, Pharmacology

Key words: Epithelial–Mesenchymal Transition, NOL6, Nucleolar Protein, Tumorigenesis, TWIST1 [more]

Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis

NS Dey, S Senaratne, V Somaratne, NP Madarasinghe, B Seneviratne, S Forrester, M Montes de Oca, L Capos Reis, S Moulik, PB Walrad, M Chatterjee, H Goto, R Wickremasinghe, D Lagos, PM Kaye, S Ranasinghe

The Journal of Clinical Investigation (American Society of Clinical Investigation) UK, Sri Lanka, Brazil, India, 05 October 2021

Immunology, Parasitology

Key words: Immunology, Infectious Disease [more]

Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model

MK Chiang, PY Hsiao, YY Liu, HL Tang, CS Chiou, MC Lu, YC Lai

Gut Microbes (Taylor & Francis) Taiwan, 04 October 2021

Oncology, Microbiology

Key words: Klebsiella Pneumoniae, ST11, Colorectal Tumorigenesis, IL-10, M2 Macrophages [more]

Epstein-Barr Virus Promotes Tumor Angiogenesis by Activating STIM1-Dependent Ca2+ Signaling in Nasopharyngeal Carcinoma

J Ye, J Wei, Y Luo, Y Deng, T Que, X Zhang, F Liu, J Zhang, X Luo

Pathogens (MDPI) China, 03 October 2021

Oncology, Virology

Key words: Epstein-Barr Virus, Stromal Interaction Molecule 1, Tumor Angiogenesis, Nasopharyngeal Carcinoma [more]

Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer

LE Sima, S Chen, H Cardenas, G Zhao, Y Wang, C Ivan, H Huang, B Zhang, D Matei

Journal for ImmunoTherapy of Cancer (BMJ Journals) USA, Romania, 30 September 2021

Oncology

[more]

Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer's Disease in nonhuman primates

F Yue, S Feng, C Lu, T Zhang, G Tao, J Liu, C Yue, N Jing

iScience (Cell Press) China, 30 September 2021

Neuroscience

Key words: Alzheimer's Disease, Non-Human Primate, Aβ Oligomers, Aβ Plaques, Tau Tangles, Animal Model [more]

Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice

MMT Islam, D Tarnowski, M Zhang, M Trum, S Lebek, J Mustroph, H Daniel, J Moellencamp, S Pabel, S Sossalla, A El-Armouche, VO Nikolaev, AM Shah, P Eaton, LS Maier, CM Sag, S Wagner

Journal of the American Heart Association (AHA Journals) Germany, Bangladesh, UK, 29 September 2021

Cardiology

Key words: Pressure Overload, Redox, Protein Kinase A, Heart Failure [more]

Turning up the heat on non-immunoreactive tumors: pyroptosis influences the tumor immune microenvironment in bladder cancer

X Chen, H Chen, H Yao, K Zhao, Y Zhang, D He, Y Zhu, Y Cheng, R Liu, R Xu, K Cao

Oncogene (Nature) China, Sweden, 29 September 2021

Oncology

Key words: Cancer Microenvironment, Cell Death and Immune Response, Predictive Markers [more]

Adaptive metabolic responses in a thermostabilized environment: Transgenerational trade-off implications from tropical tilapia

MC Wang, MT Hsu, CC Lin, SC Hsu, RD Chen, JR Lee, YL Chou, HP Tseng, F Furukawa, SPL Hwang, PP Hwang, YC Tseng

Science of The Total Environment (Elsevier) Taiwan, Japan, 29 September 2021

Genetics, Ecology

Key words: Thermal Variance, Cold Exposure, Transgenerational Plasticity, Metabolism, Tropical Fish [more]

Human Milk Oligosaccharides alleviate stress-induced visceral hypersensitivity and associated microbiota dysbiosis

L Ferrier, H Eutamène, L Siegwald, AM Marquard, V Tondereau, J Chevalier, GE Jacot, L Favre, V Theodorou, M Vicario, A Rytz, G Bergonzelli, CL Garcia-Rodenas

The Journal of Nutritional Biochemistry (Elsevier) Switzerland, France, Denmark, 25 September 2021

Gastroenterology

Key words: HMOs, Abdominal Pain, Chronic Psychological Stress, Antibiotics, Microbiome, Metagenomic [more]

CD8+ T effector and immune checkpoint signatures predict prognosis and responsiveness to immunotherapy in bladder cancer

X Chen, R Xu, D He, Y Zhang, H Chen, Y Zhu, Y Cheng, R Liu, R Zhu, L Gong, M Xiao, Z Wang, L Deng, K Cao

Oncogene (Nature) China, 22 September 2021

Oncology

Key words: Bladder Cancer, Immunotherapy [more]

Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study

HR Jang, M Kim, S Hong, K Lee, MY Park, KE Yang, CJ Lee, J Jeon, KW Lee, JE Lee, JB Park, K Kim, GY Kwon, YG Kim, DJ Kim, W Huh

Scientific Reports (Nature) South Korea, 22 September 2021

Nephrology

Key words: Biomarkers, Kidney Diseases, Predictive Markers, Renal Replacement Therapy [more]

Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

P Talarska, M Boruczkowski, J Żurawski

Nanomaterials (MDPI) Poland, 21 September 2021

Nanomedicine

Key words: Silver Nanoparticles, Gold Nanoparticles, Nanotoxicology, Nanoparticle Interactions, Nanoparticle Applications [more]

Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy

K Takamatsu, N Tanaka, K Hakozaki, R Takahashi, Y Teranishi, T Murakami, R Kufukihara, N Niwa, S Mikami, T Shinojima, T Sasaki, Y Sato, H Kume, S Ogawa, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, K Sawada, T Imamura, R Mizuno, M Oya

Nature Communications (Nature) Japan, 20 September 2021

Oncology

Key words: Cancer Immunotherapy, Cancer Microenvironment, Predictive Markers, Renal Cell Carcinoma, Tumour Biomarkers [more]

PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression

XY Qin, QH Shan, H Fang, Y Wang, P Chen, ZQ Xiong, DF Swaab, JN Zhou

Acta Neuropathologica (Springer) China, The Netherlands, 18 September 2021

Neuroscience

Key words: Depression, Paraventricular Nucleus, PSD-93, Corticotropin-Releasing Hormone, Synaptic Regulation [more]

Interferon Gamma-Induced Interferon Regulatory Factor 1 Activates Transcription of HHLA2 and Induces Immune Escape of Hepatocellular Carcinoma Cells

R Wang, H Guo, X Tang, T Zhang, Y Liu, C Zhang, H Yu, Y Li

Inflammation (Springer) China, 18 September 2021

Oncology, Immunology

Key words: Hepatocellular Carcinoma, HHLA2, Tumor-Associated Macrophages, PD-L1, Immune Escape, IFNG, IFR1 [more]

Experimental nerve transfer model in the neonatal rat

ME Sporer, M Aman, KD Bergmeister, D Depisch, KM Scheuba, E Unger, BK Podesser, OC Aszmann

Neural Regeneration Research (Wolters Kluwer) Austria, 17 September 2021

Regenerative Medicine, Neuroscience

Key words: brachial plexus birth injury, experimental rat model, extremity reconstruction, methodological paper, neonatal rat, nerve reconstruction, nerve regeneration, nerve transfer, neural plasticity, peripheral nerve surgery [more]

Multiomic analysis reveals comprehensive tumor heterogeneity and distinct immune subtypes in multifocal intrahepatic cholangiocarcinoma

SL Chen, Y Xie, Y Cai, H Hu, M He, L Liu, C Liao, Y Wang, J Wang, X Ren, Q Zeng, H Peng, S Shen, SQ Li, D Li, J Lai, B Peng, J Ren, M Kuang, S Peng

Clinical Cancer Research (AACR Publications) China, 15 September 2021

Oncology

Key words: Multifocal Intrahepatic Cholangiocarcinoma, Heterogeneity, Clonal Evolution, Immune Microenvironment, Immunotherapy [more]

Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress

BG Durgin, KC Wood, SA Hahn, B McMahon, JJ Baust, AC Straub

Journal of Molecular and Cellular Cardiology (Elsevier) USA, 15 September 2021

Cardiology

Key words: Smooth Muscle Cell, Redox, Hypoxia, Nitric Oxide, Hypertrophy, Soluble Guanylyl Cyclase [more]

LncRNA PVT1 knockdown ameliorates myocardial ischemia reperfusion damage via suppressing gasdermin D-mediated pyroptosis in cardiomyocytes

C Li, H Song, C Chen, S Chen, Q Zhang, D Liu, J Li, H Dong, Y Wu, Y Liu

Frontiers in Cardiovascular Medicine (Frontiers Media S.A.) China, 14 September 2021

Cardiology

Key words: lncRNA, PVT1, Myocardial Ischemia Reperfusion, Pyroptosis, Gasdermin D [more]

Estimating the time of skeletal muscle contusion based on the spatial distribution of neutrophils: a practical approach to forensic problems

Q Du, L Wang, D Li, J Niu, X Zhang, J Sun

International Journal of Legal Medicine (Springer) China, 13 September 2021

Biological Methods

Key words: Estimating Injury Time, Spatial Distribution, Immunohistochemical, Skeletal Muscle Contusion, Fisher Discriminant Analysis [more]

Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI

Y Ni, BC Hu, GH Wu, ZQ Shao, Y Zheng, R Zhang, J Jin, J Hong, XH Yang, RH Sun, JQ Liu, SJ Mo

Theranostics (Ivyspring International Publisher) China, 13 September 2021

Immunology

Key words: Neutrophil extracellular traps, Fibroblast growth factor-inducible molecule 14, Macrophages, Homeobox protein Hox-A5, Septic acute kidney injury [more]

N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation

J Li, X Hu, T Luo, Y Lu, Y Feng, H Zhang, D Liu, X Fan, Y Wang, L Jiang, Y Wang, X Hao, T Shi, Z Wang

European Journal of Medicinal Chemistry (Elsevier) China, 10 September 2021

Biomaterials

Key words: Glioma, N-2-(Phenylamino) Benzamide, Topoisomerase I Inhibitor, COX-2 Inhibitor, Pseudocycle [more]

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

S Niu, W Shi, Y Li, S Yi, Y Li, X Liu, B Cong, G He

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 08 September 2021

Neuroscience

[more]

Case Study of Noni Extract in Men with Very Low-Risk or Low-Risk Prostate Cancer

Y Hirasawa, I Pagano, JH Pharm, Y Sasaki, K Murakami, CJ Rosser, H Furuya

Hawai 'i Journal of Health & Social Welfare (hawaiijournalhealth.org) USA, 08 September 2021

Oncology

Key words: Prostate Cancer, Active Surveillance, Noni [more]

Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile

H Rossiter, D Copic, M Direder, F Gruber, S Zoratto, M Marchetti-Deschmann, C Kremslehner, M Sochorova, IM Nagelreiter, V Mlitz, M Buchberger, B Lengauer, B Golabi, S Sukseree, M Mildner, L Eckhart, E Tschachler

Autophagy (Taylor & Francis) Austria, 07 September 2021

Aging

Key words: Autophagosomes, GFP-LC3, Lipid Droplets, Perilipin, Sebocytes [more]

Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia

DR Collins, JM Urbach, ZJ Racenet, U Arshad, KA Power, RM Newman, GH Mylvaganam, NL Ly, X Lian, A Rull, Y Rassadkina, AG Yanez, MJ Peluso, SG Deeks, F Vidal, M Lichterfeld, XG Yu, GD Gaiha, TM Allen, BD Walker

Immunity (Cell Press) USA, Spain, 07 September 2021

Virology, Immunology

Key words: Human Immunology, HIV Control, CD8+ T Cell Dysfunction [more]

Reciprocal regulation of endothelial–mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease

B Vanchin, M Sol, RAF Gjaltema, M Brinker, B Kiers, AC Pereira, MC Harmsen, JAJ Moonen, G Krenning

Scientific Reports (Nature) The Netherlands, Mongolia, Brazil, 07 September 2021

Cardiology

Key words: Cell Signalling, Epigenetics, Mechanisms of Disease, Non-Coding Rnas, Pathogenesis, Vascular Diseases [more]

PAC1 receptor mediates electroacupuncture-induced neuro and immune protection during cisplatin chemotherapy

S Li, J Huang, Y Guo, J Wang, S Lu, B Wang, Y Gong, S Qin, S Zhao, S Wang, Y Liu, Y Fang, Y Guo, Z Xu, L Ulloa

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 06 September 2021

Oncology, Pharmacology

Key words: Neuromodulation, Chemotherapy, Immunosuppression, Hematopoiesis, Neurotoxic, Electroacupuncture [more]

Elevated β-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease

L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen

Brain, Behavior, and Immunity (Elsevier) China, 06 September 2021

Neuroscience

Key words: β -Secretase, CD4+ T Cell, PGE2 Signalling, Alzheimer's Disease, Neuroinflammation, T Cell Receptor (TCR) [more]

Single‐cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer

H Lai, X Cheng, Q Liu, W Luo, M Liu, M Zhang, J Miao, Z Ji, GN Lin, W Song, L Zhang, J Bo, G Yang, J Wang, WQ Gao

International Journal of Cancer (Wiley) China, 03 September 2021

Oncology

[more]

Decompartmentalisation as a simple color manipulation of plant-based marbling meat alternatives

S Ong, L Loo, M Pang, R Tan, Y Teng, X Lou, SK Chin,MY Naik, H Yu

Biomaterials (Elsevier) Singapore, 03 September 2021

Biomaterials, Tissue Engineering

Key words: Cell-Based Meat, Edible Scaffold, Meat Marbling, Cellulose, Polyphenol, Organoleptic [more]

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas

C Gribben, C Lambert, HA Messal, EL Hubber, C Rackham, I Evans, H Heimberg, P Jones, R Sancho, A Behrens

Cell Stem Cell (Cell Press) UK, Belgium, Germany, 02 September 2021

Stem Cell Research

Key words: β Cells, Pancreas, Diabetes, δ Cells, Lineage Tracing, Ngn3, Progenitor, Regeneration [more]

Nanostructured Lipid Carrier Gel Formulation of Recombinant Human Thrombomodulin Improve Diabetic Wound Healing by Topical Administration

YS Hsueh, YJ Shyong, HC Yu, SJ Jheng, SW Lin, HL Wu, JC Tsai

Pharmaceutics (MDPI) Taiwan, 02 September 2021

Biomaterials

Key words: Nanostructured Lipid Carrier, Protein Drug Delivery, Sustained Release, Chronic Wound Healing, Angiogenesis Factor, Carbopol Gel, Thrombomodulin [more]

A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution

H Yang, S Yang, F Fan, Y Li, S Dai, X Zhou, CC Steiner, B Coppedge, C Roos, X Cai, DM Irwin, P Shi

Molecular Biology and Evolution (Oxford Academic) China, USA, Germany, Canada, 01 September 2021

Genetics, Evolution

Key words: Convergent Evolution, Bitter Taste Receptors, Tas2R16, Human, White-Faced Saki, Pithecia Pithecia, Adaptive Evolution [more]

Improving Mask R-CNN for Nuclei Instance Segmentation in Hematoxylin & Eosin-Stained Histological Images

B Bancher, A Mahbod, I Ellinger, R Ecker, G Dorffner

Proceedings of Machine Learning Research (PMLR) Austria, 01 September 2021

Machine Learning

Key words: Mask R-CNN, Nuclei Segmentation, Medical Image Analysis, Deep Learning, Computational Pathology

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation

M Rath, A Pitiot, M Kirr, W Fröhlich, B Plosnita, S Schliep, J Bauerschmitz, AS Baur, C Ostalecki

International Journal of Molecular Sciences (MDPI) Germany, UK, Austria, 30 August 2021

Dermatology

Key words: Scar, Dendritic Cells, Tumor Microenvironment, Single-Cell Analysis, Multiplex Imaging, Proteases, Tumor Biology [more]

Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury

WZ Wang, X Liu, ZY Yang, YZ Wang, HT Lu

Neural Regeneration Research (Wolters Kluwer) China, 30 August 2021

Neuroscience

Key words: brain-derived neurotrophic factor, diffusion tensor imaging, fractional anisotropy value, global cerebral ischemia/reperfusion injury, hippocampus, TrkB [more]

Characteristics of Chlamydia suis Ocular Infection in Pigs

C Unterweger, A Inic-Kanada, S Setudeh, C Knecht, S Duerlinger, M Stas, D Vanrompay, C Kiekens, R Steinparzer, W Gerner, A Ladinig, T Barisani-Asenbauer

Pathogens (MDPI) Austria, Belgium, 29 August 2021

Microbiology

Key words: Chlamydia Suis, Piglets, Experimental Conjunctival Infection, Serology, Antibodies, Immunohistochemistry, Lacrimal Gland [more]

Bone Marrow Remodelling Supports Hematopoiesis in Response to Immune Thrombocytopenia Progression in Mice

OJ Herd, GF Rani, JP Hewitson, K Hogg, AP Stone, N Cooper, DG Kent, PG Genever, IS Hitchcock

Blood Advances (Elsevier) UK, 26 August 2021

Hematology

[more]

TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas

E Gonzalez-Buendia, J Zhao, L Wang, S Mukherjee, D Zhang, VA Arrieta, E Feldstein, JR Kane, SJ Kang, C Lee-Chang, A Mahajan, L Chen, R Realubit, C Karan, L Magnuson, C Horbinski, SA Marshall, JN Sarkaria, A Mohyeldin, I Nakano, M Bansal, CD James, DJ Brat, A Ahmed, P Canoll, R Rabadan, A Shilatifard, AM Sonabend

Clinical Cancer Research (AACR Publications) USA, 25 August 2021

Oncology

[more]

Biocompatible Copper Sulfide Based Nanocomposites for Artery Interventional Chemo-Photothermal Therapy of Orthotropic Hepatocellular Carcinoma

X Li, H Yuan, X Tian, J Tang, L Liu, F Liu

Materials Today Bio (Elsevier) China, 25 August 2021

Nanomedicine

Key words: DOX@BSA-CuS Nanocomposites, NIR-Responsive, Photothermal Ablation, Chemoembolization, MRI Guided Therapy [more]

Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin

R Herzog, JM Sacnun, G González-Mateo, M Bartosova, K Bialas, A Wagner, M Unterwurzacher, IJ Sobieszek, L Daniel-Fischer, K Rusai, L Pascual-Antón, K Kaczirek, A Vychytil, C Peter Schmitt, M López-Cabrera, SL Alper, C Aufricht, K Kratochwill

Science Translational Medicine (AAAS) Austria, Spain, Germany, USA, 25 August 2021

Nephrology

[more]

Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma

TH Hung, JT Hung, CE Wu, Y Huang, CW Lee, CT Yeh, YH Chung, FY Lo, LC Lai, JK Tung, J Yu, CN Yeh, AL Yu

Hepatology Communications (Wiley) Taiwan, 24 August 2021

Hepathology, Oncology

[more]

Oroxylin A promotes therapeutic efficacy of cisplatin to suppress bladder cancer progression via inducing ferroptosis

Q Tang, J Jiang, J Sun, L Tang, X Zhang

Biochemical and Biophysical Research Communications (Elsevier) China, 21 August 2021

Oncology, Pharmacology

Key words: Bladder Cancer, cDDP, Oroxylin A (OroA), Ferroptosis [more]

Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity

V Azzimato, P Chen, E Barreby, C Morgantini, L Levi, A Vankova, J Jager, A Sulen, M Diotallevi, JX Shen, A Miller, E Ellis, M Rydén, E Näslund, A Thorell, VM Lauschke, KM Channon, MJ Crabtree, A Haschemi, Sm Craige, M Mori, F Spallotta, M Aouadi

Gastroenterology (Elsevier) Sweden, France, UK, Austria, Germany, USA, Italy, 21 August 2021

Gastroenterology

Key words: Liver, Metabolism, Oxidative Stress, miRNAs, Fumarase [more]

Spatially Resolved Immunometabolism to Understand Infectious Disease Progression

R Tans, S Dey, NS Dey, G Calder, P O'Toole, PM Kaye, RMA Heeren

Frontiers in Microbiology (Frontiers Media S.A.) The Netherlands, UK, 19 August 2021

Immunology

Key words: Immunometabolism, Infectious Disease, Inflammation, Granulomas, Mass Spectrometry Imaging, Spatial Transcriptomics, Multi-Omics, Leishmaniasis

Maternal Immune Activation Causes Social Behavior Deficits and Hypomyelination in Male Rat Offspring with an Autism-Like Microbiota Profile

GA Lee, YK Lin, JH Lai, YC Lo, YCSH Yang, SY Ye, CJ Lee, CC Wang, YH Chiang, SH Tseng

Brain Sciences (MDPI) Taiwan, 18 August 2021

Neuroscience

Key words: Autism Spectrum Disorder, Lipopolysaccharide, Maternal Immune Activation, Microbiota, Three-Chamber Test, Myelination, Brain–Gut–Microbiota Axis, Social Behavior Deficits [more]

Effects of Vitamin D-Deficient Diet on Intestinal Epithelial Integrity and Zonulin Expression in a C57BL/6 Mouse Model

CY Yeung, JSC Chiau, ML Cheng, WT Chan, CB Jiang, SW Chang, CY Liu, CW Chang, HC Lee

Frontiers in Medicine (Frontiers Media S.A.) Taiwan, 16 August 2021

Gastroenterology

Key words: Vitamin D, Gut Integrity, Tight Junction, Zonulin, Leaky Gut [more]

A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge

X He, L Ding, K Cao, H Peng, C Gu, Y Li, D Li, L Dong, X Hong, X Wang, M Fu, C Qiu, C Zhu, Z Zhang, S Song, C Wang, Z Jiang, Y Xie, Z Qi, C Zhao, P Zhao, X Zhang, J Xu

Emerging Microbes & Infections (Taylor & Francis) China, 12 August 2021

SARS-CoV-2

Key words: SARS-CoV-2, Cell-Based Vaccines, K562-S, Mouse Model, Non-Human Primate Model, Neutralizing Antibody, Protection [more]

Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus

D Douchi, A Yamamura, J Matsuo, YHM Lim, N Nuttonmanit, M Shimura, K Suda, S Chen, S Pang, K Kohu, T Abe, G Shioi, G Kim, A Shabbir, S Srivastava, M Unno, JBY So, M Teh, KG Yeoh, LSH Chuang, Y Ito

Gastroenterology (Elsevier) Singapore, Japan, 12 August 2021

Gastroenterology

Key words: Metaplasia, Intramucosal Dysplasia, Invasive and Metastatic Gastric Cancer, Gastric Carcinogenesis, Mouse Model [more]

Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells

L Kappert, P Ruzicka, A Kutikhin, C De La Torre, A Fischer, M Hecker, C Arnold, T Korff

The FASEB Journal (Wiley) Germany, Russia, 12 August 2021

Cardiology

[more]

The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells

PJ Kung, TY Lai, J Cao, LC Hsu, TC Chiang, P Ou-Yang, CY Tsai, YF Tsai, CW Lin, CC Chen, MK Tsai, YW Tien, CY Lee

Cancer Immunology, Immunotherpay (Springer) Taiwan, Australia, 10 August 2021

Oncology, Immunology

Key words: S100A9, PD-L1, Pancreatic Ductal Adenocarcinoma, PSC [more]

Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer

E Shrestha, JB Coulter, W Guzman, B Ozbek, MM Hess, L Mummert, SE Ernst, JP Maynard, AK Meeker, CM Heaphy, MC Haffner, AM De Marzo, KS Sfanos

PNAS (United States National Academy of Sciences) USA, 10 August 2021

Oncology

Key words: Prostate Cancer, Infection, Inflammation, TMPRSS2:ERG Fusion, Colibactin [more]

Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultraviolet Light–Induced Pterygium

CC Lai, SH Tseng, SM Hsu, YT Huang, CC Shieh

Investigative Ophthalmology & Visual Science (ARVO Journals) Taiwan, 09 August 2021

Ophthalmology

Key words: Pterygium, Pterygial Epithelial Cells, Toll-Like Receptor 3, Ultraviolet B, NF-κB [more]

Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer

SC Wang, YC Chang, MY Wu, CY Yu, SL Chen, WW Sung

Cancers (MDPI) Taiwan, 04 August 2021

Oncology

Key words: Bladder Cancer, Azacitidine, Intravesical Instillation, TNF-R1, TRAIL-R2 [more]

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

LC Russo, R Tomasin, IA Matos, AC Manucci, ST Sowa, K Dale, KW Caldecott, L Lehtiö, D Schechtman, FC Meotti, A Bruni-Cardoso, NC Hoch

Journal of Biological Chemistry (ASBMB) Brazil, Finland, UK, 04 August 2021

SARS-CoV-2, Immunology

Key words: COVID-19, SARS-CoV-2, ADP-ribosylation, PARP9, DTX3L, macrodomain [more]

Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway

X Wu, Z Wang, Y Jiang, H Zhou, A Li, Y Wie, Z Bao, D Wang, J Zhao, X Chen, Y Guo, Z Dong, K Liu

Frontiers in Oncology (Frontiers Media S.A.) China, 04 August 2021

Oncology

Key words: Esophageal Squamous Cell Carcinoma, Tegaserod Maleate, Proteome, Peroxisome, Peroxisome Membrane Protein 11B, Peroxisome Membrane Protein 13, Patient-Derived Xenograft [more]

Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma

M Ma, G Li, M Qi, W Jiang, R Zhou

Frontiers in Immunology (Frontiers Media S.A.) China, 03 August 2021

Immunology

Key words: Asthma, Inflammasome, HDM, Alveolar Macrophage, RRx-001, NLRP3 [more]

The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca2+ overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-γ/IP3R signaling pathway

T Gao, P Yang, D Fu, M Liu, X Deng, M Shao, J Liao, H Jiang, X Li

Aging (Impact Journals) China, 03 August 2021

Cardiology

Key words: Allicin, Apoptosis, PI3K/Akt Pathway, Myocardial Ischemia/Reperfusion, Gene Expression Profiling, Calcium Signaling Pathway, GRK2, GPCR [more]

High-Precision Quantitative Analysis Reveals Carcinoembryonic Protein Expression Differs Among Colorectal Cancer Primary Foci and Metastases to Different Sites

Y Zhu, Q Zhang, C Wei, Y Hu, H Gong, Y Liu, H Lai, Y Feng, Y Lin

Technology in Cancer Research & Treatment (SAGE Journals) China, 03 August 2021

Oncology

Key words: Carcinoembryonic Protein, Colorectal Cancer, Lymph Node Metastases, Liver Metastases, Primary Foci [more]

Conifer essential oils reversed amyloid beta1-42 action by modulating BDNF and ARC expression in the rat hippocampus

PA Postu, A Tiron, CE Tiron, DL Gorgan, M Mihasan, L Hritcu

CNS & Neurological Disorders (ingentaconnect) Romania, 30 July 2021

Neuroscience

Key words: Alzheimer's disease, Pinus halepensis, Tetraclinis articulata, amyloid-beta peptide, memory, neuroprotection [more]

Causal evidence for induction of pessimistic decision-making in primates by the network of frontal cortex and striosomes

S Amemori, AM Graybiel, K Amemori

Frontiers in Neuroscience (Frontiers Media S.A.) Japan, USA, 30 July 2021

Neuroscience

Key words: Anxiety, Caudal Orbitofrontal Cortex, Pregenual Anterior Cingulate Cortex, Approach-Avoidance Conflict, Monkey, Microstimulation, Striosome Compartment, Caudate Nucleus [more]

S-nitroso human serum albumin as a nitric oxide donor in drug-eluting vascular grafts: biofunctionality and preclinical evaluation

M Enayati, KH Schneider, C Almeria, C Grasl, C Kaun, B Messner, S Rohringer, I Walter, J Wojta, L Budinsky, BH Walpoth, H Schima, G Kager, S Hallström, BK Podesser, H Bergmeister

Acta Biomaterialia (Elsevier) Austria, Slovakia, Switzerland, 28 July 2021

Cardiology

Key words: Nitric Oxide Donor, Drug Eluting Vascular Graft, Poly-Caprolactone, Electrospinning [more]

Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV

AK Mattox, J Roelands, TM Saal, Y Cheng, D Rinchai, W Hendrickx, GD Young, TJ Diefenbach, AE Berger, WH Westra, JA Bishop, WC Faquin, FM Marincola, MJ Pittet, D Bedognetti, SI Pai

The American Journal of Pathology (Elsevier) USA, Qatar, The Netherlands, 23 July 2021

Virology

[more]

Liposomal IR-780 as a Highly Stable Nanotheranostic Agent for Improved Photothermal/Photodynamic Therapy of Brain Tumors by Convection-Enhanced Delivery

YJ Lu, TS Anikumar, CC Chuang, JP Chen

Cancers (MDPI) Taiwan, 22 July 2021

Oncology

Key words: Nanomedicine, Cancer Therapy, Brain Tumor, Photothermal Therapy, Photodynamic Therapy, Liposome, IR-780, Convection Enhanced Delivery [more]

Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning

WH Yang, JS Westman, DM Heithoff, M Sperandio, JW Cho, MJ Mahan, JD Marth

PNAS (United States National Academy of Sciences) USA, South Korea, Germany, 20 July 2021

Gastroenterology

Key words: Colitis, Neuraminidase, Inflammation [more]

Electromagnetic Field‐Programmed Magnetic Vortex Nanodelivery System for Efficacious Cancer Therapy

X Liu, Y Zhang, Y Guo, W Jiao, X Gao, WSV Lee, Y Wang, X Deng, Y He, J Jiao, C Zhang, G Hu, XJ Liang, H Fan

Advanced Science (Wiley) China, Singapore, 18 July 2021

Nanomedicine, Oncology

[more]

Effect of high fat diet on the severity and repair of lung fibrosis in mice

AE Hegab, M Ozaki, S Kagawa, K Fukunaga

Stem Cells and Development (Mary Ann Liebert Inc.) Japan, 16 July 2021

Endocrinology, Pulmonology

Key words: High Fat Diet, Fibrosis, Alveolar Type-2 Cells, Bronchioalveolar Stem Cells, Fatty Acid Oxidation [more]

HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

R Fardoos, OE Asowata, N Herbert, SK Nyquist, Y Zungu, A Singh, A Ngoepe, IM Mbano, N Mthabela, D Ramjit, F Karim, W Kuhn, FG Madela, VT Manzini, F Anderson, B Berger, TH Pers, AK Shalek, A Leslie, H Kløverpris

JCI Insight (The American Society for Clinical Investigation) Denmark, South Africa, USA, 12 July 2021

SARS-CoV-2

Key words: AIDS/HIV, Covid-19 [more]

Down-regulation of A20 promotes immune escape of lung adenocarcinomas

K Breitenecker, M Homolya, AC Luca, V Lang, C Trenk, G Petroczi, J Mohrherr, J Horvath, S Moritsch, L Haas, M Kurnaeva, R Eferl, D Stoiber, R Moriggl, M Bilban, AC Obenauf, C Ferran, B Dome, V Laszlo, B Györffy, K Dezso, J Moldvay, E Casanova, HP Moll

Science Translational Medicine (AAAS) Austria, USA, Hungary, 07 July 2021

Oncology, Pulmonology

[more]

Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle

C Romagnoli, P Sharma, R Zonefrati, G Palmini, E Lucattelli, DT Ward, I Ellinger, M Innocenti, ML Brandi

International Journal of Molecular Sciences (MDPI) Italy, UK, Austria, 06 July 2021

Osteology

Key words: Skeletal Muscle, Satellite Cells, Myogenesis, Calcium-Sensing Receptor, G Protein-Coupled Receptors [more]

Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM

KEC Blokland, H Habibie, T Borghuis, GJ Teitsma, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess

Cells (MDPI) The Netherlands, Australia, Indonesia, Canada, 29 June 2021

Pulmonology

Key words: Extracellular Matrix, Senescence, Idiopathic Pulmonary Fibrosis, Proinflammatory, Profibrotic [more]

Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo

CC Ku, K Wuputra, K Kato, JB Pan, CP Li, MH Tsai, M Noguchi, Y Nakamura, CJ Liu, TF Chan, MF Hou, S Wakana, YC Wu, CS Lin, DC Wu, KK Yokoyama

Stem Cell Research & Therapy (BMC) Taiwan, Japan, 29 June 2021

Neuroscience

Key words: Antioxidation, Cerebellum, Granule Cells, Jun Dimerization Protein 2 (Jdp2), Reactive Oxygen Species (ROS) [more]

Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma

J Xu, N Yu, P Zhao, F Wang, J Huang, Y Cui, H Ding, Y Yang, Y Gao, L Pan, H Chang, Y Wu, B Xiang, Y Gong, X Shuai, L Hou, L Xie, T Niu, T Liu, L Zhang, W Liu, W Zhang, Y Qu, W Lin, Y Zhu, S Zhao, Y Zheng

Frontiers in Oncology (Frontiers Media S.A.) China, 29 June 2021

Oncology

Key words: Extramedullary Multiple Myeloma, MIF, Immunohistochemistry Staining, Xenograft Models, Single-Cell Sequencing [more]

Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy

YX Hong, WY Wu, F Song, C Wu, GR Li, Y Wang

Aging (Impact Journals) China, 27 June 2021

Cardiology

Key words: Cardiac Senescence, Telomere Length Shortening, Mitophagy, Sirt1, Sirt6, pAMPK [more]

Inhibition of endoplasmic reticulum stress-related autophagy attenuates MCLR-induced apoptosis in zebrafish testis and mouse TM4 cells

Z Wu, F Wang, L Hu, J Zhang, D Chen, S Zhao

Ecotoxicology and Environmental Safety (Elsevier) China, 25 June 2021

Toxicology

Key words: MCLR, Autophagy, Endoplasmic Reticulum Stress, Apoptosis, Zebrafish [more]

Magneto-Activation and Magnetic Resonance Imaging of Natural Killer Cells Labeled with Magnetic Nanocomplexes for the Treatment of Solid Tumors

T Sim, B Choi, SW Kwon, KS Kim, H Choi, A Ross, DH Kim

ACS NANO (ACS Publications) USA, 24 June 2021

Nanomedicine

Key words: Natural Killer Cell, Magneto-Activation, Nanocomplexes, Cell Labeling, Cancer Therapy [more]

Omega-Class Glutathione Transferases of Carcinogenic Liver Fluke, Clonorchis sinensis, Modulate Apoptosis and Differentiation of Host Cholangiocytes

CS Ahn, JG Kim, I Kang, Y Kong

Antioxidants (MDPI) South Korea, 24 June 2021

Parasitology

Key words: Clonorchis Sinensis, Omega-Class Glutathione Transferase, Cholangiocyte, Oxidative Stress, Programmed Cell Death, Cell Differentiation, Protein Kinase, Gene Regulation [more]

Hematological consequences of malaria in mice previously treated for visceral leishmaniasis

GF Rani, H Ashwin, N Brown, IS Hitchcock, PM Kaye

Wellcome Open Research (Wellcome Open Research) UK, 18 June 2021

Parasitology

Key words: visceral leishmaniasis, malaria, mouse models, hematology, chemotherapy, coinfection [more]

Investigating Transcriptional Dynamics Changes and Time-Dependent Marker Gene Expression in the Early Period After Skeletal Muscle Injury in Rats

K Ren, L Wang, L Wang, Q Du, J Cao, Q Jin, G An, Na Li, L Dang, Y Tian, Y Wang, J Sun

Frontiers in Genetics (Frontiers Media S.A.) China, 17 June 2021

Genetics

Key words: Time-Series RNA-Seq, Gene Expression and Regulation Landscape, Time-Related Biomarkers, Transcriptional Dynamics, Skeletal Muscle Injury [more]

DNA polymerase β deficiency promotes the occurrence of esophageal precancerous lesions in mice

J Qin, Y Zhu, Y Ding, T Niu, Y Zhang, H Wu, L Zhu, B Yuan, Y Qiao, J Lu, K Liu, Z Dong, G Jin, X Chen, J Zhao

Neoplasia (Elsevier) China, 15 June 2021

Oncology

Key words: Polβ, NMBA, Esophageal Precancerous Lesion [more]

Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

H Mathsyaraja, J Catchpole, B Freie, E Eastwood, E Babaeva, M Geuenich, PF Cheng, J Ayers, M Yu, N Wu, S Moorthi, KR Poudel, A Koehne, W Grady, AM Houghton, AH Berger, Y Shiio, D MacPherson, RN Eisenman

eLife (eLife Sciences Publications) USA, 11 June 2021

Oncology

Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice

NR Rao, JN Savas

Journal of Proteome Research (ACS Publications) USA, 09 June 2021

Cell Biology

Key words: Mass Spectrometry, Peptides and Proteins, Central Nervous System, Rodent Models, Endocytosis [more]

A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL‐40‐IL‐13 Receptor α2 Axis

Y van Sleen, WF Jiemy, S Pringle, KSM van der Geest, WH Abdulahad, M Sandovici, E Brouwer, P Heeringa, AMH Boots

Arthritis & Rheumatology (Wiley) The Netherlands, Malaysia, 08 June 2021

Rheumatology

[more]

A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer

SC Chang, CS Hung, BX Zhang, TH Hsieh, W Hsu, JL Ding

Cancers (MDPI) Taiwan, 08 June 2021

Oncology

Key words: CCNF, FBXL8, FZR1, RRM2, E3 Ubiquitin Ligase, Breast Cancer, Metastasis [more]

Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma

SA O'Connor, HM Feldman, S Arora, P Hoellerbauer, CM Toledo, P Corrin, L Carter, M Kufeld, H Bolouri, R Basom, J Delrow, JL McFaline-Figueroa, C Trapnell, SM Pollard, A Patel, PJ Paddison, CL Plaisier

Molecular Systems Biology (EMBO press) USA, UK, 08 June 2021

Neuroscience

[more]

Determining optimal clinical target volume margins in high-grade glioma based on microscopic tumor extension and magnetic resonance imaging

S Nie, Y Zhu, J Yang, T Xin, S Xue, X Zhang, J Sun, D Mu, Y Gao, Z Chen, X Ding, J Yu, M Hu

Radiation Oncology (BMC) China, 07 June 2021

Oncology

Key words: High-Grade Glioma, Macropathology, Microscopic Extension, Predictive Model, Clinical Target Volume, Radiotherapy [more]

Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer

W Liu, Y Wang, Y Xie, T Dai, M Fan, C Li, Y Zou

Cell Death Discovery (Nature) China, 05 June 2021

Oncology

Key words: Cancer Microenvironment [more]

Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment

O Nebie, K Carvalho, L Barro, L Delila, E Faivre, TY Renn, M-Li Chou, YW Wu, A Niem-Redene, SY Chou, L Buée, CJ Hu, Chih-Wei Peng, D Devos, D Blum, T Burnouf

Brain (Oxford Academic) Taiwan, France, 04 June 2021

Neuroscience

Key words: Human Platelet Lysate, Traumatic Brain Injury, Neuroprotection, Neurorestoration, Neurotrophins [more]

MoNuSAC2020: A Multi-organ Nuclei Segmentation and Classification Challenge

R Verma, N Kumar, A Patil, NC Kurian, S Rane, S Graham, QD Vu, M Zwager, SEA Raza, N Rajpoot, X Wu, H Chen, Y Huang, L Wang, H Jung, GT Brown, Y Liu, S Liu, SAF Jahromi, AA Khani, E Montahaei, MS Baghshah, H Behroozi, P Semkin, A Rassadin, P Dutande, R Lodaya, U Baid, B Baheti, S Talbar, A Mahbod, R Ecker, I Ellinger, Z Luo, B Dong, Z Xu, Y Yao, S Lv, M Feng, K Xu, H Zunair, AB Hamza, S Smiley, TK Yin, QR Fang, S Srivastava, D Mahapatra, L Trnavska, H Zhang, PL Narayanan, J Law, Y Yuan, A Tejomay, A Mitkari, D Koka, V Ramachandra, L Kini, A Sethi

IEEE Transactions on Medical Imaging (IEEE Xplore) USA, Canada, India, The Netherlands, China, USA, China, Iran, Russia, Austria, Taiwan, UAE, Slovakia, UK, 04 June 2021

Medical Image Analysis

Key words: Multi-Organ Dataset, Nucleus Classification, Computational Pathology, Instance Segmentation, Panoptic Quality

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice

KP Hammer, J Mustroph, T Stauber, W Birchmeier, S Wagner, LS Maier

PLoS One (PLOS) Germany, 04 June 2021

Physiology

Key words: Exercise, Running, Arrhythmia, Mouse Models, Heterozygosity, Phosphorylation, Physical Activity, Sedentary Behavior [more]

Synthetic Fibrin-Derived Bβ15-42 Peptide Delays Thrombus Resolution in a Mouse Model

S Chausheva, B Redwan, S Sharma, N Marella, K Schlossleitner, AC Mueller, P Petzelbauer, T Morris, IM Lang

Arteriosclerosis, Thrombosis and Vascular Biology (American Heart Association) Austria, Germany, 03 June 2021

Cardiology

Key words: Macrophages, Microvessels, Monocyte, Plasma, Venous Thrombosis [more]

Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study

CE Tiron, E Patrașcanu, PA Postu, IC Vacarean Trandafir, A Tiron, I Grigoras

Current Issues in Molecular Biology (MDPI) Romania, 02 June 2021

Oncology

Key words: AKT, Breast Cancer, EMT, HIF, Sevoflurane, Vimentin [more]

Lactate modulates cellular metabolism through histone lactylation-mediated gene expression in non-small cell lung cancer

J Jiang, DL Huang, Y Jiang, J Hou, MY Tian, JH Li, Li Sun, YG Zhang, T Zhang, ZQ Li, ZC Li, SX Tong

Frontiers in Oncology (Frontiers Media S.A.) China, 02 June 2021

Oncology

Key words: Lactate, Lactylation, Metabolism, Gene Expression, Non-Small Cell Lung Cancer [more]

Disruption of Tfh: B cell interactions prevents antibody-mediated rejection in a kidney transplant model in rats: impact of calcineurin inhibitor dose

L Steines, H Poth, A Schuster, K Amann, B Banas, T Bergler

Frontiers in Immunology (Frontiers Media S.A.) Germany, 31 May 2021

Transplantation Medicine

Key words: Antibody-Mediated Rejection, Donor-Specific Antibodies, Kidney Transplantation, T Follicular Helper Cells, B Cell Activation, Calcineurin Inhibitor [more]

Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation

JP Hohensinner, M Lenz, P Haider, J Mayer, M Richter, C Kaun, L Goederle, M Brekalo, M Salzmann, S Sharma, MB Fischer, S Stojkovic, D Ramsmayer, C Hengstenberg, BK Podesser, K Huber, CJ Binder, J Wojta, WS Speidl

Biochemical Pharmacology (Elsevier) Austria, 28 May 2021

Endocrinology

[more]

Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma

JY Chen, WH Cheng, KY Lee, HP Kuo, KF Chung, CL Chen, BC Chen, CH Lin

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, UK, 27 May 2021

Pulmonology

Key words: Chronic Obstructive Asthma, Airway Fibrosis, ADAM17, EGFR, Human Lung Fibroblasts [more]

Investigating the Impact of the Bit Depth of Fluorescence-Stained Images on the Performance of Deep Learning-Based Nuclei Instance Segmentation

A Mahbod, G Schaefer, C Löw, G Dorffner, R Ecker, I Ellinger

Diagnostics (MDPI) Austria, UK, 27 May 2021

Medical Image Analysis

Key words: Bit Depth, Nuclei Segmentation, Fluorescence Staining, Medical Image Analysis, Computational Pathology, Deep Learning

Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection

WF Garcia-Beltran, DT Claiborne, CR Maldini, M Phelps, V Vrbanac, ME Karpel, KL Krupp, KA Power, CL Boutwell, AB Balazs, AM Tager, M Altfeld, TM Allen

Frontiers in Immunology (Frontiers Media S.A.) USA, Germany, 26 May 2021

Immunology

Key words: Innate Immunity, T Cells, HIV-1, HuBLT, BLT, Humanized Mice [more]

Magneto Mitochondrial Dysfunction Mediated Cancer Cell Death Using Intracellular Magnetic Nano-Transducers

W Park, SJ Kim, P Cheresh, J Yun, B Lee, DW Kamp, DH Kim

Biomaterials Science (Royal Society of Chemistry) USA, South Korea, 26 May 2021

Oncology

[more]

Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response

I Vargova, L Machova Urdzikova, K Karova, B Smejkalova, T Sursal, V Cimermanova, K Turnovcova, CD Gandhi, M Jhanwar-Uniyal, P Jendelova

Biomedicines (MDPI) Czech Republic, USA, 24 May 2021

Regenerative Medicine, Neuroscience

Key words: Spinal Cord Injury, mTOR, Rapamycin, pp242, Dual Inhibition, Autophagy, Inflammation [more]

Remdesivir Alleviates Acute Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome

L Yin, H Zhao, H Zhang, Y Li, Y Dong, H Ju, F Kong, S Zhao

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 21 May 2021

Immunology, Pharmacology

Key words: Remdesivir, NLRP3 Inflammasome or NOD-, LRR-, Pyrin Domain-Containing Protein 3 (NLRP3)Inflammasome, NF-κB, Macrophage, Acute Kidney Injury [more]

Evaluation of a Novel Tilapia-skin Acellular Dermis Matrix Rationally Processed for Enhanced Wound Healing

D Li, WQ Sun, T Wang, Y Gao, J Wu, Z Xie, J Zhao, C He, M Zhu, S Zhang, P Wang, X Mo

Materials Science and Engineering: C (Elsevier) China, 21 May 2021

Tissue Engineering

Key words: Tilapia Skin, Decellularization, Wound Healing, Degradation, Re-Epithelialization [more]

Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-Based Novel Therapy against Endotoxemia in Mice

HJ Shih, CY Chang, M Chiang, VL Le, HJ Hsu, CJ Huang

Journal of Personalized Medicine (MDPI) Taiwan, Vietnam, 20 May 2021

Pharmacology

Key words: TNF-α, IL-1β, IL-6, Necroptosis, Pyroptosis, Apoptosis, Liver [more]

Piezo2 downregulation via the Cre-lox system affects aqueous humor dynamics in mice

J Fang, F Hou, S Wu, Y Liu, L Wang, J Zhang, N Wang, K Wang, W Zhu

Molecular Vision (Emory University) China, 20 May 2021

Ophthalmology

[more]

Tissue image cytometry

A Meshcheryakova, F Mungenast, R Ecker, D Mechtcheriakova

Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 1 (IOP Publishing) Austria, 15 May 2021

Medical Image Analysis

Modulation of the anticancer activities of paclitaxel by Cremophor micelles

JL Chiang, YW Yang

International Journal of Pharmaceutics (Elsevier) Taiwan, 14 May 2021

Oncology

Key words: Cell Cycle, Cremophor, Micelle, Paclitaxel, Polyploidy [more]