Customer Publications (A total of 3186 papers published)
Interplay between Partial EMT and Cisplatin Resistance as the Drivers for Recurrence in HNSCC
Biomedicines (MDPI) Austria, Romania, 05 October 2022
Oncology
Key words: partial EMT, cisplatin resistance, StrataQuest, SCC-25 cells [more]
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions
Cellular and Molecular Life Sciences (Springer) Singapore, Bangladesh, 05 October 2022
Neuroscience
Key words: Sphingosine-1-phosphate, S1P transporters, S1P signaling, Neuroinflammation, Multiple sclerosis Lymphocyte egress [more]
Organism: Mouse
Tissue: Brain, Spinal Cord
In-situ vaccination using dual responsive organelle targeted nanoreactors
Biomaterials (Elsevier) Singapore, UK, USA, 04 October 2022
Nanomedicine
Key words: In-situ vaccine, Dual-responsive, Backbone shattering, Combination therapy, Orthotopic glioblastoma mice model, Personalized medicine [more]
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
Heart-targeting exosomes from human cardiosphere-derived cells improve the therapeutic effect on cardiac hypertrophy
Journal of Nanobiotechnology (BMC) China, 04 October 2022
Nanomedicine
Key words: Genetic engineering, Exosomes, Heart homing peptide, Cardiosphere-derived cells, Cardiac hypertrophy [more]
Organism: Rat
Tissue: Heart, Lung, Kidney
Pathological State: Cardiac hypertrophy
Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs
Nature Communications (Nature) China, 01 October 2022
Neuroscience
Key words: Neurophysiology, Non-coding RNAs, Reproductive biology, RNA transport [more]
Organism: Mouse
Tissue: Brain
Gut–Brain Axis: Insights from Hippocampal Neurogenesis and Brain Tumor Development in a Mouse Model of Experimental Colitis Induced by Dextran Sodium Sulfate
International Journal of Molecular Sciences (MDPI) Italy, Spain, 29 September 2022
Developmental Biology
Key words: DSS-induced colitis, brain, neuroinflammation, adult hippocampal neurogenesis, metabolomics, medulloblastoma [more]
Organism: Mouse
Tissue: Brain, Colon
Pathological State: Colitis
BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation
Scientific reports (Nature) Taiwan, 29 September 2022
Oncology
Key words: Cancer, Lung cancer, Non-small-cell lung cancer, Oncology [more]
Organism: Mouse
Tissue: Lung, Xenograft Tumor
Pathological State: Cancer
A novel ceRNA regulatory network involving the long noncoding NEAT1, miRNA-466f-3p and its mRNA target in osteoblast autophagy and osteoporosis
Journal of Molecular Medicine (Springer) China, 28 September 2022
Osteology
Key words: LncRNA NEAT1, MiRNA-466f-3p, HK2, Autophagy, Osteoblast [more]
Organism: Mouse
Tissue: Bone
Assessment of traditional Chinese medicine pattern in a bleomycin-induced pulmonary fibrosis mouse model: A pilot study
Journal of Traditional Chinese Medical Sciences (Elsevier) China, 28 September 2022
Pulmonology
Key words: Bleomycin, Idiopathic pulmonary fibrosis, Pattern characteristics, Tongue image, Fibrinolytic factor, Inflammatory factor [more]
Organism: Mouse
Tissue: Lung
Pathological State: Pulmonary fibrosis
Tick feeding modulates the human skin immune landscape to facilitate tick-borne pathogen transmission
The Journal of Clinical Investigation (American Society of Clinical Investigation) Austria, 27 September 2022
Parasitology
Organism: Human
Tissue: Skin
Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers
Clinical Cancer Research (AACR Publications) UK, The Netherlands, Australia, Belgium, 26 September 2022
Oncology, Immunology
Organism: Human
Tissue: Breast
Pathological State: Cancer
Azelnidipine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by targeting MEK1/2
Molecular Therapy Oncolytics (Elsevier) China, 26 September 2022
Oncology
Key words: Esophageal squamous cell carcinoma, Azelnidipine, Proliferation, Cell cycle, MEK1/2 inhibitor, MEK1/2-ERK1/2 signaling pathway [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Correlation analysis of tumor purity with clinicopathological, molecular, and imaging features in high-grade gliomas
Neurosurgical Review (Springer) China, 26 September 2022
Oncology, Medical Image Analysis
Key words: High-grade gliomas, Tumor purity, Tumor microenvironment, Neuroimaging [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Microcystin-leucine-arginine affects brain gene expression programs and behaviors of offspring through paternal epigenetic information
Science of The Total Environment (Elsevier) China, 24 September 2022
Developmental Biology
Key words: Paternal epigenetic inheritance, Neurodevelopment in offspring, DNA methylation, Microcystin-LR, Cross-generational effects [more]
Organism: Zebrafish
Tissue: Testis
Lithium Treatment Improves Cardiac Dysfunction in Rats Deprived of Rapid Eye Movement Sleep
International Journal of Molecular Sciences (MDPI) Taiwan, 23 September 2022
Cardiology
Key words: rapid eye movement sleep deprivation, lithium, antifibrosis, cardioprotection [more]
Organism: Rat
Tissue: Heart
Pathological State: Cardiac fibrosis
Truncation mutations in MYRF underlie primary angle closure glaucoma
Human Genetics (Springer) China, USA, 21 September 2022
Ophthalmology
Organism: Mouse
Tissue: Eye
Lenvatinib synergistically promotes radiotherapy in hepatocellular carcinoma by inhibiting Src/STAT3/NF-κB-mediated epithelial–mesenchymal transition and metastasis
International Journal of Radiation Oncology*Biology*Physics (Elsevier) Taiwan, 19 September 2022
Oncology, Radiotherapy
Key words: Radiotherapy, lenvatinib, Src, epithelial–mesenchymal transition, hepatocellular carcinoma [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Phosphorus fractions and iron oxides responsible for the variations in the Cd retention capacity in tropical soil aggregates under different cropping patterns
Journal of Hazardous Materials (Elsevier) China, USA, 19 September 2022
Ecology
Key words: Cadmium, Tropical soil aggregates, Adsorption characteristics, P fractions, Fe oxides [more]
Organism: Soil
FDX1 expression predicts favourable prognosis in clear cell renal cell carcinoma identified by bioinformatics and tissue microarray analysis
Frontiers in Genetics (Frontiers Media S.A.) China, 16 September 2022
Oncology
Key words: ferredoxin 1, clear cell renal cell carcinoma, cuproptosis, metastasis, tumourigenesis, tissue microarray analyses, prognostic biomarker [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
A neurogenic signature involving monoamine Oxidase-A controls human thermogenic adipose tissue development
Elife (eLife Sciences Publications) USA, 15 September 2022
Developmental Biology
Organism: Human
Tissue: Adipose Tissue
Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells
Nature Metabolism (Nature) China, USA, 15 September 2022
Neuroscience, Toxicology
Key words: Cerebellum, Ion channels in the nervous system, Metabolism, Neurophysiologym [more]
Organism: Mouse
Tissue: Brain
ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model
Scientific Reports (Springer) Taiwan, UK, 14 September 2022
Oncology
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Penicillium digitatum, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient
Journal of Fungi (MDPI) Chile, 14 September 2022
SARS-CoV-2, Immunology
Key words: Penicillium digitatum, COVID-19, pulmonar infection, pneumonia [more]
Cell Line: Penicillium digitatum fungal culture
Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren's syndrome
Scientific Reports (Nature) USA, Japan, 14 September 2022
Immunology, Rheumatology
Key words: Diseases, Immunology, Pathogenesis, Rheumatology [more]
Organism: Human
Tissue: Salivary Gland
Pathological State: Sjögren's syndrome
Ultrasmall zirconium carbide nanodots for synergistic photothermal-radiotherapy of glioma
Nanoscale (Royal Society of Chemistry) China, 13 September 2022
Nanomedicine, Radiotherapy
Visualization of macrophage subsets in the development of the fetal human inner ear
Frontiers in Immunology (Frontiers Media S.A.) Austria, Sweden, Canada, UK, 09 September 2022
Developmental Biology
Key words: fetal human inner ear, macrophages, development, IBA-1, CD45, CD68, CD163, CX3CL1 [more]
Organism: Human
Tissue: Embryo
In utero arsenic exposure increases DNA damage and gene expression changes in umbilical cord mesenchymal stem cells (UC-MSCs) from newborns as well as in UC-MSC differentiated hepatocytes
Toxicology Reports (Elsevier) Thailand, 07 September 2022
Toxicology, Reproductive Medicine
Key words: Arsenic, In utero exposure, 8-OHdG, 8-nitroguanine, Mesenchymal stem cells [more]
Cell Line: Human mesenchymal stem cells
Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial.
Current Health Sciences Journal (EBSCO) Romania, 05 September 2022
Tissue Engineering
Cell Line: Collagen Matrix
Interleukin-4 receptor alpha signaling regulates monocyte homeostasis.
The FASEB Journal (Wiley) Austria, 05 September 2022
Immunology
Key words: homeostasis, immunity, innate, interleukin-4, monocytes, receptors, signal transduction [more]
Organism: Mouse
Tissue: Spleen
Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection
Cancers (MDPI) Germany, 31 August 2022
Oncology
Key words: colorectal cancer, metastasis, mouse models, mouse-derived organoids, orthotopic transplantation, tumor heterogeneity, clonal selection, niche [more]
Organism: Mouse
Tissue: Colon
Pathological State: Cancer
PPsNet: An Improved Deep Learning Model for Microsatellite Instability High Prediction in Colorectal Cancer from Whole Slide Images
Computer Methods and Programs in Biomedicine (Elsevier) China, UK, 31 August 2022
Medical Image Analysis
Key words: Colorectal cancer, Microsatellite instability, Deep learning, Deep supervision, Pair-wise learning, Synergic network, Parameter sharing, Whole slide images [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer
Science Translational Medicine (Science) Austria, USA, UK, Brazil, 31 August 2022
Pharmacology, Oncology
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Identification and validation of a poor clinical outcome subtype of primary prostate cancer with Midkine abundance
Cancer Science (Wiley) China, 26 August 2022
Oncology
Organism: Human
Tissue: Prostate
Pathological State: Cancer
P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma
Frontiers in Oncology (Frontiers Media S.A.) Brazil, Italy, 25 August 2022
Pharmacology, Oncology
Key words: P2X7 receptor isoforms, chemoresistance, childhood cancer, cancer, drug efflux, cancer stem cells, autophagy, epithelial-mesenchymal transition [more]
Cell Line: ACN human neuroblastoma cells
KI Essence extract (a spleen-tonifying formula) promotes neurite outgrowth, alleviates oxidative stress and hypomyelination, and modulates microbiome in maternal immune activation offspring
Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan, 25 August 2022
Pharmacology
Key words: mushroom, maternal immune activation, myelination, microbiota, oxidative stress, spleen-tonifying formula [more]
Organism: Rat
Tissue: Brain
Thymidine and 2′-deoxyuridine reduce microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35 induced brain injury
Archives of Biochemistry and Biophysics (Elsevier) China, 24 August 2022
Neuroscience
Key words: Thymidine, 2′-deoxyuridine, Glycolytic metabolism, Microglia activation, Oxidative stress, Brain injury [more]
Organism: Mouse
Tissue: Brain
Pathological State: Aβ25-35-induced brain injury
Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC.
Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 24 August 2022
Oncology
Key words: Immunity, Innate, Immunotherapy, Liver Neoplasms, Lymphocytes, Tumor-Infiltrating, Tumor Microenvironment [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
The medial wall and medial compartment of the cavernous sinus: an anatomic study using plastinated histological sections
Neurosurgical Review (Springer) China, 19 August 2022
Neuroscience
Key words: Cavernous sinus, Medial wall, Dura mater, Plastination [more]
Organism: Human
Tissue: Bone
Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae
Ecotoxicology and Environmental Safety (Elsevier) Taiwan, 17 August 2022
Toxicology, Zoology
Key words: Zinc oxide nanoparticles (ZnONPs, Danio rerio, Surface modification, Liver toxicity, Developmental changes, Autophagy [more]
Organism: Zebrafish
Tissue: Embryo
TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma
The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 16 August 2022
Oncology, Immunology
Organism: Human
Tissue: Mucosa
Pathological State: Cancer
Papillary Renal Neoplasm with Reverse Polarity—a Comparative Study with CCPRCC, OPRCC, and PRCC1
Human Pathology (Elsevier) China, 14 August 2022
Nephrology
Key words: Papillary renal neoplasm with reverse polarity, Papillary renal cell carcinoma type 1, Clear cell papillary renal cell carcinoma, Oncocytic papillary renal cell carcinoma, Whole exon sequencing, KRAS [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Comparison of H7N9 and H9N2 influenza infections in mouse model unravels the importance of early innate immune response in host protection
Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) China, 12 August 2022
Virology, Immunology
Key words: H7N9, H9N2, pathological characteristics, C57BL/6 mice, lung [more]
Organism: Mouse
Tissue: Lung
Pathological State: Influenza Infection
Stereotaxic atlas of the infant rat brain at postnatal days 7–13
Frontiers in Neuroanatomy (Frontiers Media S.A.) China, France, 12 August 2022
Neuroscience, Developmental Biology
Key words: infant rat, brain, atlas, stereotaxic coordinates, neural development [more]
Organism: Rat
Tissue: Brain
Short-Term Cortical Electrical Stimulation during the Acute Stage of Traumatic Brain Injury Improves Functional Recovery
Biomedicines (MDPI) Taiwan, 12 August 2022
Neuroscience
Key words: traumatic brain injury, neural stem cells, cortical electrical stimulation, functional recovery [more]
Organism: Rat
Tissue: Brain
Pathological State: Traumatic Brain Injury
Preclinical Therapeutic Evaluation of Lenvatinib-Eluting Microspheres for Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma
CardioVascular and Interventional Radiology (Springer) USA, 12 August 2022
Oncology
Key words: Transcatheter arterial chemoembolization, Hepatocellular carcinoma, Lenvatinibm, Drug eluting microspheres, Local drug delivery [more]
Organism: Rat
Tissue: Lung, Heart, Kidney
Pathological State: Cancer
Effects of Cordyceps militaris fermentation products on reproductive development in juvenile male mice
Scientific Reports (Nature) China, Taiwan, 12 August 2022
Nutritional science
Key words: Nutrition, Quality of life [more]
Organism: Mouse
Tissue: Testis
m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs
iScience (Cell Press) China, 11 August 2022
Ophthalmology
Key words: m6A, YTHDF1, YTHDF2, YTHDF3, Cortical neurogenesis, Retinal neurogenesis [more]
Organism: Mouse
Tissue: Embryo
Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice
Journal of Functional Foods (Elsevier) China, 11 August 2022
Gastroenterology
Key words: Alzheimer's disease, Camellia oil, Gut microbiota, Lipid metabolism, PPARs [more]
Organism: Mouse
Tissue: Brain
Disulfiram increases the efficacy of 5-fluorouracil in organotypic cultures of colorectal carcinoma
Biomedicine & Pharmacotherapy (Elsevier) Czech Republic, 10 August 2022
Oncology
Key words: Disulfiram/copper, 5-fluorouracil, Synergism, Organotypic culture, Spheroid, Colorectal carcinoma [more]
Organism: Spheroid
Cell Line: HT-29 and HCT-116 human adenocarcinoma cells
Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus
Immunity (Cell Press) USA, 10 August 2022
Immunology
Key words: influenza virus, universal, B cell, vaccine, broad, antibody gene polymorphism, autoreactivityt, olerance [more]
Cell Line: Hep2 cell
Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma
iScience (Cell Press) China, 10 August 2022
Oncology, Immunology
Key words: Immunology, Biocomputational method, Genomic analysis, Cancer [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Club cells employ regeneration mechanisms during lung tumorigenesis
Nature Communications (Nature) Germany, 05 August 2022
Oncology
Key words: Cancer models, Cancer stem cells, Lung cancer, Mechanisms of disease [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest
Cell death Discovery (Nature) China, USA, UK, 02 August 2022
Cell Biology
Key words: Cell biology, Development [more]
Organism: Mouse
Tissue: Testis
Alleviating experimental allergic eye disease by inhibiting pro-lymphangiogenic VEGFR3 signal
The Ocular Surface (Elsevier) China, 02 August 2022
Ophthalmology
Key words: Allergic eye disease, Lymphatics, Vegfr3, CD4+ T cell, Lymph node [more]
Organism: Mouse
Tissue: Eye, Small Intestine
Pathological State: Allergy
Intermittent hilar occlusion attenuates or prevents renal ischaemia-reperfusion in mice
Biomedicine & Pharmacotherapy (Elsevier) China, 01 August 2022
Nephrology
Key words: Partial nephrectomy, Ischaemia-reperfusion injury, Oxidative damage, Laboratory animal models [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Renal fibrosis
Sulfur mustard single-dose exposure triggers senescence in primary human dermal fibroblasts
Archives of Toxicology (Springer) Germany, 29 July 2022
Toxicology
Key words: Sulfur mustard, Senescence, Human dermal fibroblasts, Wound healing disorder [more]
Cell Line: Human primary dermal fibroblasts
A Chinese medical nutrition therapy diet accompanied by intermittent energy restriction alleviates type 2 diabetes by enhancing pancreatic islet function and and regulating gut microbiota composition
Food Research International (Elsevier) China, 28 July 2022
Gastroenterology, Endocrinology
Key words: Type 2 diabetes, Diet, Intermittent energy restriction, Chinese Medical Nutrition Therapy, Pancreatic islet function, Gut microbiota [more]
Organism: Mouse
Tissue: Pancreas
A Natural Gas Fermentation Bacterial Meal (FeedKind®) as a Functional Alternative Ingredient for Fishmeal in Diet of Largemouth Bass, Micropterus salmoides
Antioxidants (MDPI) China, UK, 28 July 2022
Zoology
Key words: largemouth bass, methanotroph (Methylococcus capsulatus, Bath) bacteria meal (FeedKind®), growth performance, antioxidant capacity, intestinal health [more]
Organism: Bass Fish
Tissue: Small Intestine
Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial
Current Health Sciences Journal (Medical University Publishing House Craiova) Romania, 28 July 2022
Biomaterials
Key words: Biocomposite, collagen-hydroxyapatite, biocompatibility
High Glucose Aggravates Retinal Endothelial Cell Dysfunction by Activating the RhoA/ROCK1/pMLC/Connexin43 Signaling Pathway
Investigative Ophthalmology & Visual Science (ARVO Journals) China, 26 July 2022
Ophthalmology
Key words: diabetic retinopathy, retinal vascular endothelial cells, RhoA/ROCK1/pMLC signaling, ROCK inhibitor, connexin43 [more]
Organism: Mouse
Tissue: Eye
Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 Macrophages through PI3K/Akt/mTOR Signaling Pathway
Pathogens and Global Health (Taylor & Francis) China, 25 July 2022
Immunology
Key words: Echinococcus multilocularis, glycolysis, macrophage polarization, protoscoleces, PI3K/Akt/mTOR [more]
Organism: Human
Tissue: Liver
Pathological State: Echinococcus Infection
Tegaserod Maleate Suppresses the Growth of Gastric Cancer In Vivo and In Vitro by Targeting MEK1/2
Cancers (MDPI) China, 23 July 2022
Oncology
Key words: gastric cancer, tegaserod maleate, MEK1, MEK2, chemoprevention [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
miR-429 negatively regulates the progression of hypoxia-induced retinal neovascularization by the HPSE-VEGF pathway
Experimental Eye Research (Elsevier) China, 22 July 2022
Ophthalmology
Key words: Neovascularization, Heparanase, miR-429, Retinopathy, VEGF [more]
Organism: Mouse
Tissue: Eye
Hexavalent chromium exposure induces intestinal barrier damage via activation of the NF-κB signaling pathway and NLRP3 inflammasome in ducks
Frontiers in Immunology (Frontiers Media S.A.) China, Pakistan, 22 July 2022
Zoology
Key words: hexavalent chromium, intestinal barrier, NF-κB, NLRP3, duck [more]
Organism: Duck
Tissue: Small Intestine
Autologous exosome facilitates load and target delivery of bioactive peptides to repair spinal cord injury
Bioactive Materials (Elsevier) China, 22 July 2022
Neuroscience
Key words: Spinal cord injury, Targeted repair, Autologous plasma exosome, Drug loading, Axon regeneration [more]
Organism: Mouse
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Rice co-expression network analysis identifies gene modules associated with agronomic traits
Plant Physiology (Oxford Academic) China, 22 July 2022
Agricultural Science
Organism: Rice
Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter's Trans-Formed DLBCL and Germinal Center B-Cells
International Journal of Molecular Sciences (MDPI) Austria, Germany, 17 July 2022
Oncology
Key words: diffuse large B-cell lymphoma, Richter syndrome, transformed follicular lymphoma, chemokine receptors, CCR7, CCL19, CCL21 [more]
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: Cancer
MiRNA-Mediated Fibrosis in the Out-of-Target Heart following Partial-Body Irradiation
Cancers (MDPI) Italy, UK, Ireland, Germany, 16 July 2022
Cardiology
Key words: miRNome, Raman spectroscopy, abscopal effect, cardiac fibrosis, miR-1, mir-133a [more]
Organism: Mouse
Tissue: Heart
LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer
Molecular Cancer (Springer) USA, China, 16 July 2022
Oncology
Key words: LINE-1, Transposable element, NSCLC, LUSC, LUAD, FGGY, Metabolic [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Suppression of Allergic Asthma by Loss of Function of Miz1-Mediated Th1 Skewing
American Journal of Respiratory Cell and Molecular Biology (ATS Journals) USA, 14 July 2022
Allergy Research
Key words: Asthma, Gene regulation, Th1/Th2 immunity, Miz1, IL-12
The prostate tissue‐based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy
The Journal of Pathology: Clinical Research (Wiley) USA, 14 July 2022
Oncology
Organism: Human
Tissue: Prostate
Pathological State: Cancer
Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice
Advanced Science (Wiley) Taiwan, 13 July 2022
Aging
Organism: Mouse
Tissue: Heart
Pathological State: Tissue Fibrosis
Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC)
Cell Death & Disease (Nature) China, 13 July 2022
Oncology
Key words: Cancer immunotherapy, Cancer microenvironment, Non-small-cell lung cancer [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
The Interplay of NEAT1 and miR-339-5p Influences on Mesangial Gene Expression and Function in Various Diabetic-Associated Injury Models
Non-Coding RNA (MDPI) Germany, 13 July 2022
Endocrinology, Genetics
Key words: NEAT1, has-miR-339-5p, diabetic kidney disease, mesangial cell, lncRNA, miRNA [more]
Cell Line: Human mesangial cells
Pharmacologic modulation of intracellular Na+ concentration with ranolazine impacts inflammatory response in humans and mice
PNAS (United States National Academy of Sciences) Austria, Slovenia, 13 July 2022
Immunology
Key words: Inflammation, Atherosclerosis, Endothelium, NF-κB, Ranolazine [more]
Organism: Mouse
Tissue: Blood Vessels
Pathological State: Atherosclerotic plaques
CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection
Nature Communications (Nature) South Africa, USA, Germany, UK, 12 July 2022
Immunology, Virology
Key words: HIV infections, Lymph node, Retrovirus [more]
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: HIV Infection
Angiotensin-Converting Enzyme 2 Potentiates SARS-CoV-2 Infection by Antagonizing Type I Interferon Induction and Its Down-Stream Signaling Pathway
mSphere (ASM Journals) China, 12 July 2022
Immunology, SARS-CoV-2
Pathological State: Covid-19
Cell Line: A549, HEK293T, NCI-H1299, and Vero E6 cell lines
MicroRNA-21-5p promotes mucosal type 2 inflammation via regulating GLP1R/IL-33 signaling in chronic rhinosinusitis with nasal polyps
Journal of Allergy and Clinical Immunology (Elsevier) China, 11 July 2022
Allergy Research
Key words: Chronic rhinosinusitis with nasal polyps, Glucagon-like peptide-1 receptor, MicroRNA-21-5p, Type 2 inflammation [more]
Organism: Human
Tissue: Mucosa
Pathological State: chronic rhinosinusitis
Molecular species of oxidized phospholipids in brain differentiate between learning-and memory impaired and unimpaired aged rats
Amino Acids (Springer) Austria, Egypt, 11 July 2022
Neuroscience
Key words: Prefrontal cortex, Memory, Phospholipids, Learning [more]
Organism: Rat
Tissue: Brain
The immune microenvironment features and response to immunotherapy in EBV-associated lymphoepithelioma-like cholangiocarcinoma
Hepatology International (Springer) Taiwan, 03 July 2022
Hepathology
Key words: Intrahepatic cholangiocarcinoma, Epstein–Barr virus, Lymphoepithelioma-like cholangiocarcinoma, Tumor immune microenvironment, Adaptive immune response, T cells, Macrophages, PD-1, PD-L1, Immune checkpoint blockade [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology (BMC) South Africa, USA, 01 July 2022
Immunology
Key words: Follicular regulatory T cells (TFRs), Follicular helper T (TFH) cells, Lymph node, Biomarkers, HIV [more]
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: HIV Infection
Mutations in GCK May Lead to MODY2 by Reducing Glycogen Synthesis
Advanced Biology (Wiley) China, 30 June 2022
Endocrinology
Cell Line: HepG2 cells
Long-Molecule Assessment of Ribosomal DNA and RNA
(Queen Mary University of London) UK, 30 June 2022
Bioimaging
Organism: Human
Cell Line: Human Lymphoblastoid Cell Lines
An optimized method for obtaining clinical‐grade specific cell subpopulations from human umbilical cord‐derived mesenchymal stem cells
Cell Proliferation (Wiley) China, 29 June 2022
Biological Methods
Organism: Human
Cell Line: hUC-MSCs
The long-term survival and functional maturation of human iNPC-derived neurons in the basal forebrain of cynomolgus monkeys
Life Medicine (Oxford Academic) China, 28 June 2022
Stem Cell Research, Neuroscience
Key words: Non-human primates, Cerebral cell transplantation, Human induced neural stem/progenitor cells, Neuronal differentiation, Functional maturation [more]
Organism: Monkey
Tissue: Brain
Hepatitis B virus X gene impacts on the innate immunity and immune‐tolerant phase in chronic hepatitis B virus infection
Liver International (Wiley) Taiwan, 28 June 2022
Hepathology, Immunology
Organism: Human
Tissue: Liver
Pathological State: Chronic hepatitis B
Cancer-Associated Fibroblasts Promote Tumor Aggressiveness in Head and Neck Cancer through Chemokine Ligand 11 and CC Motif Chemokine Receptor 3 Signaling Circuit
Cancers (MDPI) Taiwan, 27 June 2022
Oncology
Key words: head and neck cancer, cancer-associated fibroblasts, CCL11, CCR3, tumor microenvironment [more]
Pathological State: Cancer
Cell Line: FaDu cell lines (HTB-43 - ATCC)
Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure
Particle and Fibre Toxicology (BMC) China, USA, 23 June 2022
Pulmonology
Key words: Particle matter, Chronic lung injuries, Single-cell RNA sequencing, IL-17A, Myeloid-derived suppressor cells [more]
Organism: Mouse
Tissue: Lung
Pathological State: Pulmonary Fibrosis
Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment
Journal of Advanced Research (Elsevier) Taiwan, 22 June 2022
Oncology, Pharmacology
Key words: Cancer, Drug design, HDAC6/HSP90 dual inhibitor, Immunosensitizer, Tumor microenvironment [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis
Genes & Diseases (Elsevier) China, 21 June 2022
Ophthalmology
Key words: Apoptosis, Glaucoma, Phagocytosis, PLSCR1, Retinal ganglion cells [more]
Organism: Mouse
Tissue: Eye
Pathological State: Glaucoma
A diagnostic pitfall; small cell carcinoma-like features in basaloid squamous cell carcinoma of the esophagus
Histology and Histopathology (Griffith University) Japan, Australia, Germany, 21 June 2022
Oncology
Key words: esophagus, biopsy, basaloid squamous cell carcinoma, small cell carcinoma, diagnostic pitfall [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer's Disease
International Journal of Molecular Sciences (MDPI) Taiwan, USA, France, 20 June 2022
Neuroscience, Pharmacology
Key words: neurodegenerative disease, Alzheimer's disease (AD), passive immunotherapy, encapsulated cell therapy, microtube array membrane (MTAMs) [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer's Disease
Clinical value of urinary cytokines/chemokines as prognostic markers in patients with crescentic glomerulonephritis
Scientific reports (Nature) South Korea, 17 June 2022
Nephrology
Key words: Chemokines, Cytokines, Kidney diseases [more]
Organism: Human
Tissue: Kidney
Pathological State: Crescentic Glomerulonephritis
Decreased CD11c‐positive dendritic cells in the tumor microenvironment predict double‐hit/triple‐hit genotype and survival in diffuse large B‐cell lymphoma
The Journal of Pathology: Clinical Research (Wiley) Taiwan, 17 June 2022
Oncology
Key words: high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, double-hit lymphoma, triple-hit lymphoma, diffuse large B-cell lymphoma, tumor microenvironment, dendritic cell, decision curve analysis [more]
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: Cancer
Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF‐κB pathway
Cell Proliferation (Wiley) China, 16 June 2022
Osteology
Organism: Mouse
Tissue: Bone
Pathological State: Osteoporosis
Evaluation of Topical and Subconjunctival Injection of Hyaluronic Acid-Coated Nanoparticles for Drug Delivery to Posterior Eye
Pharmaceutics (MDPI) Taiwan, China, 13 June 2022
Nanomedicine
Key words: posterior eye, hyaluronic acid, surface charges, nanoparticles, drug delivery, eyedrops, subconjunctival injection, retina [more]
Organism: Mouse
Tissue: Eye
Occurrence of Lymphangiogenesis in Peripheral Nerve Autografts Contrasts Schwann Cell-Induced Apoptosis of Lymphatic Endothelial Cells In Vitro
Biomolecules (MDPI) Austria, Germany, 12 June 2022
Neuroscience
Key words: peripheral nerve regeneration, lymphangiogenesis, Schwann cells, lymphatic endothelial cells [more]
Cell Line: Fibrin hydrogels containing Schwann cell, lymphatic endothelial cells and adipose-derived stem cells
Accumulation of Cytotoxic Skin Resident Memory T Cells and Increased Expression of IL-15 in Lesional Skin of Polymorphic Light Eruption
Frontiers in Medicine (Frontiers Media S.A.) France, Austria, 10 June 2022
Dermatology, Allergy Research
Key words: sun allergy, polymorphic light eruption, disease recurrence, inflammation, disease memory, resident memory T cell (TrM) [more]
Organism: Human
Tissue: Skin
Pathological State: Polymorphic light eruption (PLE)
A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells
Cancers (MDPI) Sweden, Australia, 10 June 2022
Oncology
Key words: colorectal liver metastases, tumor-infiltrating lymphocytes, tissue-resident memory T cells, patient-derived xenograft model, MEK inhibition [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Long‐term outcomes of arterial ischemia or venous occlusion on vascularized groin lymph nodes in a rat model
Journal of Surgical Oncology (Wiley) Taiwan, Austria, 09 June 2022
Angiology
Key words: arterial ischemia, lymphedema, vascularized lymph node transfer, venous congestion [more]
Organism: Rat
Tissue: Lymphoid Tissue
Pathological State: Arterial ischemia
Proteomic analysis of hepatic fibrosis induced by a high starch diet in largemouth bass (Micropterus salmoides)
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics (Elsevier) China, 08 June 2022
Zoology, Endocrinology
Key words: High starch diet, Hepatic fibrosis, Proteomics, PRM, Micropterus salmoides [more]
Organism: Bass Fish
Tissue: Liver
Pathological State: Hepatic fibrosis
Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5
Cell Death Discovery (Nature) China, 07 June 2022
Oncology
Key words: Cancer, Oncogenesis [more]
Organism: Human
Tissue: Uterus
Pathological State: Cancer
Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses
Cell Reports (Cell Press) China, 07 June 2022
Immunology
Key words: OTUD3, RIG-I, MDA5, cGAS, deubiquitination, innate immunity [more]
Organism: Mouse
Tissue: Lung
Pathological State: Virus Infection
Loss of core-fucosylation of SPARC impairs collagen binding and contributes to COPD
Cellular and Molecular Life Sciences (Springer) Taiwan, 07 June 2022
Pulmonology
Key words: COPD, Fut8, Core-fucosylation, SPARC, Matricellular protein, Collagen [more]
Organism: Human
Tissue: Lung
Pathological State: Chronic obstructive pulmonary disease
Diffusion tensor imaging reveals brain structure changes in dogs after spinal cord injury
Neural Regeneration Research (Publishing House of Neural Regeneration Research) China, 06 June 2022
Neuroscience
Key words: spinal cord injury, diffusion tensor imaging, canines, pathophysiology, cerebrospinal structures, corticospinal tract, magnetic resonance imaging, anisotropic fraction, apparent dispersion coefficient [more]
Organism: Dog
Tissue: Brain
Pathological State: Spinal cord injury
Fecal Microbiota Transfer Attenuates Gut Dysbiosis and Functional Deficits After Traumatic Brain Injury
Shock (Wolters Kluwer) USA, 06 June 2022
Neuroscience, Gastroenterology
Key words: Traumatic brain injury, fecal microbiome transplantation, microbiome, dysbiosis, trauma, controlled cortical impact, behavior, anxiety [more]
Organism: Mouse
Tissue: Brain
Pathological State: Traumatic Brain Injury
FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1
Journal of Cellular and Molecular Medicine (Wiley) China, 03 June 2022
Oncology
Key words: FOXM1, glycolysis, nasopharyngeal carcinoma, PDK1, proliferation [more]
Organism: Human
Tissue: Mucosa
Pathological State: Cancer
A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer
Advanced Biology (Wiley) China, 02 June 2022
Oncology
Organism: Human
Cell Line: HCC cells
Ultra-Fine Polyethylene Hernia Meshes Improve Biocompatibility and Reduce Intraperitoneal Adhesions in IPOM Position in Animal Models
Biomedicines (MDPI) Germany, 31 May 2022
Tissue Engineering
Key words: polyethylene mesh, biocompatibility, IPOM, ultrafine diameter filaments, adhesion formation, animal trials [more]
Tissue: Surgical mesh
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma
International Journal of Oncology (Spandidos Publications) China, 31 May 2022
Oncology
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice
Brain Sciences (MDPI) China, USA, 30 May 2022
Neuroscience, Gastroenterology
Key words: microbiota-gut-brain axis, brain aging, gut microbiota, Atp11b, aging pathology [more]
Organism: Mouse
Tissue: Brain
Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway
Investigative Ophthalmology & Visual Science (ARVO Journals) China, 26 May 2022
Ophthalmology
Organism: Human
Tissue: Meibomian Gland
Catalpol Attenuates Pulmonary Fibrosis by Inhibiting Ang II/AT1 and TGF-β/Smad-Mediated Epithelial Mesenchymal Transition
Frontiers in Medicine (Frontiers Media S.A.) China, 24 May 2022
Pulmonology
Key words: idiopathic pulmonary fibrosis, Ang II, TGF-β/Smad signaling pathway, EMT, catalpol [more]
Organism: Mouse
Tissue: Lung
Pathological State: Pulmonary Fibrosis
Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications
Nanomaterials (MDPI) Romania, 24 May 2022
Nanomedicine
Key words: polyhistidine copolymers, micelles, doxorubicin, tumor cells, release studies [more]
Cell Line: Micelles
Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma
Journal for ImmunoTherapy of Cancer (BMJ Journals) USA, 23 May 2022
Oncology, Immunology
Key words: Brain Neoplasms, Central Nervous System Neoplasms, Drug Evaluation, Preclinical, Programmed Cell Death 1 Receptor, Vaccination [more]
Organism: Human
Cell Line: DTG-IDH1 cells
Tumor acidity-responsive polymeric nanoparticles to promote intracellular delivery of zoledronic acid by PEG detachment and positive charge exposure for enhanced antitumor potency
Journal of Materials Chemistry B (Royal Society of Chemistry) Taiwan, 23 May 2022
Nanomedicine
Key words: Endocrinology [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Adverse Effects of Single Neutrophil Extracellular Trap-Derived Components on Bovine Sperm Function
Animals (MDPI) Chile, Germany, 20 May 2022
Reproductive Medicine, Zoology
Key words: bovine, spermatozoon, bull, neutrophil extracellular traps, membrane integrity [more]
Organism: Cow
Cell Line: polymorphonuclear neutrophils, Spermatozoa
Topography-Mediated Enhancement of Nonviral Gene Delivery in Stem Cells
Pharmaceutics (MDPI) China, The Netherlands, 20 May 2022
Pharmacology
Key words: topography, proliferation, gene delivery, endocytosis, transfection [more]
Organism: Human
Cell Line: hBM-MSCs
Di-(2-ethylhexyl) Phthalate Promotes Allergic Lung Inflammation by Modulating CD8α+ Dendritic Cell Differentiation via Metabolite MEHP-PPARγ Axis
Frontiers in Immunology (Frontiers Media S.A.) Taiwan, USA, 19 May 2022
Immunology
Key words: allergic lung inflammation, dendritic cell, PPAR γ, low-dose exposure, di-(2-ethylhexyl) phthalate, mono-(2-ethylhexyl) phthalate (MEHP) [more]
Organism: Mouse
Tissue: Lung
Pathological State: Allergic Lung Inflammation
Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts
Nature Communications (Nature) China, 19 May 2022
Oncology
Key words: Cancer immunotherapy, Cancer therapeutic resistance, Drug delivery [more]
Organism: Mouse
Tissue: Liver
Pathological State: Cancer
Concurrent Germline and Somatic Mutations in FLCN and Preliminary Exploration of Its Function: A Case Report
Frontiers in Oncology (Frontiers Media S.A.) China, 19 May 2022
Oncology
Key words: Birt-Hogg-Dube (BHD) syndrome, folliculin (FLCN), mutation, renal cancer, TFEB/TFE3 [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Combination neoantigen-based dendritic cell vaccination and adoptive T-cell transfer induces antitumor responses against recurrence of hepatocellular carcinoma
Cancer Immunology Research (AACR Publications) China, 18 May 2022
Oncology, Immunology
Organism: Human
Tissue: Liver
Pathological State: Cancer
Adenosine ameliorated Aβ25− 35-induced brain injury through the inhibition of apoptosis and oxidative stress via an ERα pathway
Brain Research (Elsevier) China, 18 May 2022
Neuroscience
Key words: Adenosine, Brain injury, ERα, Apoptosis, Oxidative stress [more]
Organism: Mouse
Tissue: Brain
Pathological State: Brain injury
Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells
Journal of The American Society of Nephrology (ASN) UK, Austria, Italy, Australia, USA, France, Denmark, 17 May 2022
Endocrinology
Key words: calcium-sensing receptor, mineral metabolism, vascular calcification, hypercalcemia, transgenic mouse, vascular smooth muscle [more]
Organism: Mouse
Tissue: Kidney
Downregulated ADAMTS1 Incorporating A2M Contributes to Tumorigenesis and Alters Tumor Immune Microenvironment in Lung Adenocarcinoma
Biology (MDPI) Taiwan, 16 May 2022
Oncology
Key words: A2M, ADAMTS1, EMT, immunity, LUAD, metastasis [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Organ‐specific immune response in lethal SARS‐CoV‐2 infection by deep spatial phenotyping
Clinical & Translational Immunology (Wiley) Singapore, 15 May 2022
SARS-CoV-2, Immunology
Key words: COVID-19, immunopathology, in situ spatial multiplexing, SARS-CoV-2 infection [more]
Organism: Human
Tissue: Lung, Small Intestine, Heart
Pathological State: COVID-19
Translocon-associated protein subunit SSR3 determines and predicts susceptibility to paclitaxel in breast cancer and glioblastoma
Clinical Cancer Research (AACR Publications) USA, Germany, Hungary, 12 May 2022
Oncology
Key words: Paclitaxel, biomarker, glioblastoma, breast cancer, SSR3 [more]
Organism: Mouse
Tissue: Breast
Pathological State: Cancer
Novel Elastic Threads for Intestinal Anastomoses: Feasibility and Mechanical Evaluation in a Porcine and Rabbit Model
International Journal of Molecular Sciences (MDPI) Germany, The Netherlands, 11 May 2022
Tissue Engineering
Key words: biomaterial, TPU, surgical thread, suture material, elastic suture, gastrointestinal anastomosis
Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG4-related disease and Kimura disease
Journal of Allergy and Clinical Immunology (Elsevier) Japan, USA, Italy, 11 May 2022
Immunology
Key words: Single-cell RNA sequencing, IgG4-related disease, IgG4-RD, IgG4, IgE, Tfh cell, B cell, interleukin-10, class switch, fibrosis [more]
Organism: Human
Tissue: Salivary Gland
Pathological State: IgG4-related disease, Kimura disease
In vitro testicular toxicity of environmentally relevant endocrine-disrupting chemicals: 2D vs. 3D models of prepubertal Leydig TM3 cells
Environmental Toxicology and Pharmacology (Elsevier) Czech Republic, 10 May 2022
Reproductive Medicine, Toxicology
Key words: 3D in vitro models, Endocrine-disrupting chemicals, Leydig cells, Lipotoxicity, Reproductive toxicity, Spheroids [more]
Tissue: Spheroid
Cell Line: Leydig TM3 cells
AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice—A Pilot Study
International Journal of Molecular Sciences (MDPI) Austria, Germany, 09 May 2022
Oncology, Gastroenterology
Key words: aged mice, colitis associated colorectal cancer, AOM, DSS, mouse strain differences, pilot study [more]
Organism: Mouse
Tissue: Colon
Pathological State: Cancer
Hybrid PEGylated chitosan/PLGA nanoparticles designed as pH-responsive vehicles to promote intracellular drug delivery and cancer chemotherapy
International Journal of Biological Macromolecules (Elsevier) Taiwan, 05 May 2022
Nanomedicine, Oncology
Key words: Acidity-responsive nanovehicles, PEGylated chitosan, cancer chemotherapy [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Multinucleated Retinal Pigment Epithelial Cells Adapt to Vision and Exhibit Increased DNA Damage Response
Cells (MDPI) China, 05 May 2022
Key words: multinucleation, retinal pigment epithelium, reactive oxygen species, photoreceptor, DNA damage, p53 [more]
Organism: Mouse
Tissue: Eye
Macrophage-associated immune checkpoint CD47 blocking ameliorates endometriosis
Molecular Human Reproduction (Oxford Academic) China, 05 May 2022
Reproductive Medicine
Key words: apoptosis, endometriosis, immune checkpoint, immunotherapy, macrophage, phagocytosis [more]
Organism: Human
Tissue: Endometrium
Pathological State: Endometriosis
DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide
Mutation Research/Genetic Toxicology and Environmental Mutagenesis (Elsevier) Brazil, 05 May 2022
Toxicology
Key words: XP-V, Temozolomide, Polymerase eta, DNA damage, Translesion synthesis, Cisplatin [more]
Organism: Human
Cell Line: TLS-deficient cell line XP30RO
miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization
Carcinogenesis (Oxford Academic) China, 02 May 2022
Oncology
Key words: Tiam1, breast cancer, metastasis, glucose metabolism reprogramming, miR-21-5p [more]
Organism: Human
Cell Line: BC cell lines
SAM and folic acid prevent arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells by modulating expression of inflammatory and DNA repair genes
Chemico-Biological Interactions (Elsevier) Thailand, 02 May 2022
Toxicology
Key words: Arsenic, S-adenosyl methionine (SAM), Folic acid, DNA methylation, 8-hydroxydeoxyguanosine (8-OHdG), 8-nitroguanine [more]
Organism: Human
Cell Line: Lymphoblast cells (RPMI 1788)
Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse
Investigative Ophthalmology & Visual Science (ARVO Journals) China, UK, 02 May 2022
Ophthalmology, Neuroscience
Organism: Mouse
Tissue: Eye
ITGB1 Suppresses Autophagy Through Inhibiting The mTORC2/AKT Signaling Pathway In H9C2 Cells
Die Pharmazie-An International Journal of Pharmaceutical Sciences (Avoxa - Mediengruppe Deutscher Apotheker GmbH) China, 01 May 2022
Pharmacology
Organism: Rat
Tissue: Heart
Prognostic Value of Characterizing Myocardial Tissue by Cardiac MRI with T1 Mapping in HFpEF Patients: A Systematic Review and Meta-Analysis
Journal of Clinical Medicine (MDPI) Russia, 30 April 2022
Cardiology
Key words: cardiac MRI, HFpEF, T1 mapping, extracellular volume, native T1, postcontrast T1, prognosis
The Overexpression of Insulin-Like Growth Factor-1 and Neurotrophin-3 Promote Functional Recovery and Alleviate Spasticity After Spinal Cord Injury
Frontiers in Neuroscience (Frontiers Media S.A.) China, 29 April 2022
Neuroscience
Key words: spinal cord injury, nerve repair, nerve growth factor, NT-3, IGF-1, motor function recovery, spasticity, mechanical pain [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Epidermotropism of inflammatory cells differentiates pyoderma gangrenosum from venous leg ulcers
Journal of the German Society of Dermatology (Wiley) Germany, 29 April 2022
Dermatology
Organism: Human
Tissue: Skin
Pathological State: Ulcer
Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model
Neoplasia (Elsevier) Taiwan, 29 April 2022
Oncology
Key words: MLL translocation, KRAS mutation, Hoxa11, Hoxa10, Myeloid sarcoma, Migration [more]
Organism: Mouse
Cell Line: Mouse MLL/AF10 leukemia cell lines
Prognostic values of B7-H3, B7-H4, and HHLA2 expression in human pancreatic cancer tissues based on mIHC and spatial distribution analysis
Pathology-Research and Practice (Elsevier) China, 29 April 2022
Oncology
Key words: B7-H3, B7-H4, HHLA2, Multi-color immunohistochemistry, Prognosis, Pancreatic cancer [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma
Cancers (MDPI) Germany, The Netherlands, USA, UK, 27 April 2022
Oncology
Key words: cholangiocarcinoma, liver cancer, tumor microenvironment, nerve fiber density, immune checkpoint, immune cells [more]
Organism: Human
Tissue: Bile duct
Pathological State: Cancer
Corallodiscus flabellata BL Burtt extract and isonuomioside A ameliorate Aβ25− 35-induced brain injury by inhibiting apoptosis, oxidative stress, and autophagy via the NMDAR2B/CamK Ⅱ/PKG pathway
Phytomedicine (Elsevier) China, 27 April 2022
Toxicology
Key words: Isonuomioside A, Corallodiscus flabellata B. L. Burtt extract, NMDAR2B, Apoptosis, Oxidative stress, Autophagy [more]
Organism: Mouse
Tissue: Brain
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target
Science Signaling (Science) Brazil, USA, 26 April 2022
Pharmacology
Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site
Microbiology Spectrum (ASM Journals) China, 25 April 2022
Microbiology, Neuroscience
Organism: Mouse
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Oxidative Stress-Induced Growth Inhibitor (OSGIN1), a Target of X-Box-Binding Protein 1, Protects Palmitic Acid-Induced Vascular Lipotoxicity through Maintaining Autophagy
Biomedicines (MDPI) Taiwan, 25 April 2022
Cell Biology
Key words: palmitic acid, OSGIN1, unfolded protein response, XBP1s, autophagy, eNOS, endothelial cells [more]
Organism: Human
Tissue: Blood Vessels
Pathological State: Atherosclerosis
HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer
Nature Genetics (Nature) USA, 25 April 2022
Oncology
Key words: Epigenomics, Prostate cancer, Targeted therapies [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
HLA class I downregulation in progressing metastases of melanoma patients treated with ipilimumab
Pathology and Oncology Research (Elsevier) Hungary, Austria, USA, 22 April 2022
Oncology
Key words: immunotherapy, melanoma, ipilimumab, HLA class I expression, longitudinal study [more]
Organism: Human
Tissue: Skin
Pathological State: Cancer
Increased fatty acid metabolism attenuates cardiac resistance to β-adrenoceptor activation via mitochondrial reactive oxygen species: A potential mechanism of hypoglycemia-induced myocardial injury in diabetes
Redox Biology (Elsevier) China, 21 April 2022
Endocrinology
Key words: Hypoglycemia, Diabetes, Lipid metabolism, β-adrenoceptor, Mitochondrial reactive oxygen species [more]
Organism: Mouse
Tissue: Heart
CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by
International Journal of Biological Sciences (Ivyspring International Publisher) China, 20 April 2022
Cardiology, Oncology
Key words: CIRBP, Cardioprotection, OGFR, Chemotherapy-induced cardiotoxicity, Cardiomyocyte apoptosis [more]
Organism: Mouse
Tissue: Heart
CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis
Journal of Inflammation Research (Dovepress) China, 20 April 2022
Pulmonology
Key words: chronic obstructive pulmonary disease, emphysema, B cell, bioinformatics analysis [more]
Organism: Human
Tissue: Lung
Pathological State: Chronic obstructive pulmonary disease
Endocrine-disrupting chemicals affect sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro
Food and Chemical Toxicology (Elsevier) Czech Republic, 19 April 2022
Reproductive Medicine
Key words: Connexins, Endocrine-disrupting chemicals, Gap junctional intercellular communication, Reproductive toxicity, Sertoli cells, Testicular tumors [more]
Organism: Human
Cell Line: Sertoli TM4 cells
Computer-assisted evaluation enhances the quantification of interstitial fibrosis in renal implantation biopsies, measures differences between frozen and paraffin sections, and predicts delayed graft function
Journal of Nephrology (Springer) Austria, France, 19 April 2022
Medical Image Analysis
Key words: Implantation biopsy, Interstitial fibrosis, Computer-assisted evaluation, Delayed graft function [more]
Organism: Human
Tissue: Kidney
Pathological State: Interstitial fibrosis
Robust delivery of RIG‐I agonists using extracellular vesicles for anti‐cancer immunotherapy
Journal of Extracellular Vesicles (Wiley) Singapore, 16 April 2022
Oncology
Organism: Mouse
Tissue: Lung, Xenograft Tumor
Pathological State: Cancer
Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging
Magnetic Resonance Imaging (Elsevier) Japan, 16 April 2022
Bioimaging
Key words: Breast cancer, Magnetic resonance imaging, Diffusion weighted imaging, Diffusion kurtosis imaging, Histology [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
The significance of NAD+ metabolites and nicotinamide N-methyltransferase in chronic kidney disease
Scientific Reports (Nature) Japan, 16 April 2022
Nephrology
Key words: Medical research, Nephrology [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Kidney Disease
Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway
Journal of Experimental & Clinical Cancer Research (BMC) China, 15 April 2022
Oncology
Key words: Esophageal squamous cell carcinoma, IL-32, Extracellular vesicle, M2 macrophage polarization, Metastasis [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice
Carbohydrate Polymers (Elsevier) China, 14 April 2022
Gastroenterology
Key words: Polysaccharides, Molecular weight, Prebiotic fiber, Protection, Dysbiosis [more]
Organism: Mouse
Tissue: Colon
Pathological State: Dysbiosis
AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia
International Journal of Molecular Sciences (MDPI) Spain, Austria, 13 April 2022
Oncology
Key words: neuroblastoma, calcium-sensing receptor, calcimimetic, cinacalcet, AC-265347, biased signaling, differentiation, cancer-testis antigens [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
A phase 1b study of OXIRI in pancreatic adenocarcinoma patients and its immunomodulatory effects
International Journal of Cancer (Wiley) Singapore, 12 April 2022
Oncology
Key words: PDAC, OXIRI, metronomic oxaliplatin, chronomodulated capecitabine, UGT1A1, irinotecan [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy
Cell Death & Disease (Nature) China, 12 April 2022
Ophthalmology
Key words: Apoptosis, Cell death [more]
Organism: Mouse
Tissue: Eye
Pathological State: Diabetes, Retinopathy
Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome
Molecules (MDPI) China, 12 April 2022
Neuroscience
Key words: eriodictyol, homoeriodictyol, NLRP3 inflammasome, Alzheimer's disease, Aβ25–35 [more]
Organism: Mouse
Tissue: Brain
Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy
Theranostics (Ivyspring International Publisher) Singapore, Hong Kong, China, 11 April 2022
Oncology
Organism: Mouse
Tissue: Spleen
Pathological State: Cancer
ERBB2D16 Expression in HER2 Positive Gastric Cancer Is Associated With Resistance to Trastuzumab.
Frontiers in Oncology (Frontiers Media S.A.) China, 07 April 2022
Oncology
Key words: gastric cancer, ERBB2d16, epithelial-mesenchymal transition, immunosuppression, trastuzumab resistance [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
Rho kinase inhibition ameliorates vascular remodeling and blood pressure elevations in a rat model of apatinib-induced hypertension
Journal of Hypertension (Wolters Kluwer) China, 07 April 2022
Cardiology
Key words: RhoA/Rho-associated coiled-coil domain-containing protein kinase signaling pathway, apatinib, hypertension, tyrosine kinase inhibitors, vascular endothelial growth factor
Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis
Nature Biomedical Engineering (Nature) China, Israel, 07 April 2022
Nanomedicine, Gastroenterology
Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice
Communications Biology (Nature) China, 06 April 2022
Neuroscience
Key words: 3-D reconstruction, Fluorescence imaging, Light-sheet microscopy, Neural circuits, Viral tracing [more]
Organism: Mouse
Tissue: Brain
Inhibition of CXXC5 function reverses obesity‐related metabolic diseases
Clinical and Translational Medicine (Wiley) South Korea, 05 April 2022
Endocrinology
Organism: Mouse
Tissue: Pancreas
Pathological State: Obesity
Inhibiting MNK kinases promotes macrophage immunosuppressive phenotype to limit CD8+ T cell anti-tumor immunity
JCI Insight (American Society for Clinical Investigation) USA, 05 April 2022
Immunology, Oncology
Key words: MNK kinases, tumor-associated macrophages, CD8+ T cells, immunotherapy, antiPD-1 antibody, anti-CSF-1R antibody, pancreatic cancer, thyroid cancer [more]
Organism: Human
Tissue: Thyroid
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques
Protein & cell (Springer) China, 04 April 2022
SARS-CoV-2, Immunology
Key words: SARS-CoV-2, NRP1, inflammation, central nervous system, viral encephalitis, rhesus macaque [more]
Organism: Monkey
Tissue: Lung
Pathological State: COVID-19
KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion
EBioMedicine (Elsevier) China, Sweden, 01 April 2022
Cell Biology, Neuroscience
Key words: Extracellular vesicles, Lysosomes, KIBRA, Amyloid β, Alzheimer's disease [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer's disease
Extracellular Vesicles Derived from SIPA1high Breast Cancer Cells Enhance Macrophage Infiltration and Cancer Metastasis through Myosin-9
Biology (MDPI) China, Japan, 31 March 2022
Oncology
Key words: breast cancer, extracellular vesicles, macrophage, myosin-9, SIPA1 [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Prenatal infection predisposes offspring to enhanced susceptibility to imiquimod-mediated psoriasiform dermatitis in mice
Dermatologica Sinica (Taiwanese Society for Investigative Dermatology) Taiwan, 30 March 2022
Dermatology
Key words: Bacterial infection, lipopolysaccharide, polyinosinic:polycytidylic acid, psoriasis, psoriatic arthritis, viral infection [more]
Organism: Mouse
Tissue: Skin
Pathological State: Psoriasis
Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology (Elsevier) USA, Japan, 29 March 2022
SARS-CoV-2, Immunology
Key words: COVID-19, CD8+ T cells, Cytotoxic CD4+ T cells [more]
Organism: Human
Tissue: Lung, Lymphoid Tissue
Pathological State: COVID-19
FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway
The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 29 March 2022
Oncology
Organism: Mouse
Tissue: Ovaries, Xenograft Tumor
Pathological State: Cancer
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration
Cell Death & Differentiation (Nature) China, 28 March 2022
Ophthalmology
Key words: Drug development, Epigenetics [more]
Organism: Mouse
Tissue: Eye
Food Allergen Nitration Enhances Safety and Efficacy of Oral Immunotherapy in Food Allergy
Nutrients (MDPI) Austria, 25 March 2022
Allergy Research
Key words: oral immunotherapy, food allergy, protein nitration, modulated immune response [more]
Organism: Mouse
Tissue: Stomach
Pathological State: Allergy
Effects of Magnetite Nanoparticles and Static Magnetic Field on Neural Differentiation of Pluripotent Stem Cells
Stem Cell Reviews and Reports (Springer) Brazil, USA, 24 March 2022
Stem Cell Research, Nanomedicine
Key words: Neural differentiation, Magnetic nanoparticles, Magnetic field, Biomagnetic effects, Embryonic stem cells, iPSCs, Dopaminergic neurons [more]
Organism: Human
Cell Line: Induced dopaminergic neurons
Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells Mitigate Endoplasmic Reticulum Stress, Inflammation, and Lung Injury in Lipopolysaccharide-Treated Obese Mice
Antioxidants (MDPI) Taiwan, Vietnam, 23 March 2022
Endocrinology
Key words: lung injury, obesity, endoplasmic reticulum stress, exosomes, LPS [more]
Organism: Mouse
Tissue: Lung
Pathological State: Obesity
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway
Frontiers in Oncology (Frontiers Media S.A.) China, 22 March 2022
Oncology, Pharmacology
Key words: gracillin, non-small cell lung cancer, autophagy, mTOR signaling pathway, anti-tumor [more]
Organism: Mouse
Tissue: Heart, Liver, Kidney, Lung, Xenograft Tumor
Pathological State: Cancer
A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer
Journal of Biomedical Science (BMC) Taiwan, USA, 22 March 2022
Oncology
Key words: STAT1, Colorectal cancer, Stemness, Angiogenesis, 4',5,7-trihydroxyisoflavone (THIF), BODIPY-THIF [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model
Cancers (MDPI) Germany, 17 March 2022
Radiotherapy
Key words: 53BP1, cell death, DNA damage, epidermis, γ-H2AX, proton minibeam radiation therapy, DNA repair, skin model [more]
Organism: Human
Cell Line: Human reconstructed epidermis (epiCS®) models
Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis
Nature communications (Nature) China, Taiwan, 16 March 2022
Oncology
Key words: Breast cancer, Cancer stem cells, Cancer therapy, Metastasis, Tumour heterogeneity [more]
Organism: Human
Tissue: Breast, Lymphoid Tissue
Pathological State: Cancer
Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway
Nature Cell Biology (Nature) China, 15 March 2022
Oncology
Key words: Glycoproteins, Mechanisms of disease, Pancreatic cancer [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Regorafenib Reverses Temozolomide-Induced CXCL12/CXCR4 Signaling and Triggers Apoptosis Mechanism in Glioblastoma
Neurotherapeutics (Springer) Taiwan, 10 March 2022
Oncology
Key words: Glioblastoma, Temozolomide, Regorafenib, NF-κB, CXCR4/CXCL12 [more]
Organism: Mouse
Tissue: Brain, Xenograft Tumor
Pathological State: Cancer
hsa-miR-875-5p inhibits tumorigenesis and suppresses TGF-β signalling by targeting USF2 in gastric cancer
Journal of Translational Medicine (Springer) China, 07 March 2022
Oncology
Key words: miR-875-5p, USF2, Gastric cancer, TGF-β [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy
ACS NANO (ACS Publications) China, 03 March 2022
Oncology
Key words: Nitric oxide, Immunogenic cell death, NO nanogenerator, Vaccination effects, PD-1 blockade therapy [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Low miR-10b-3p associated with sorafenib resistance in hepatocellular carcinoma
British Journal of Cancer (Nature) Taiwan, USA, 02 March 2022
Oncology
Key words: Hepatocellular carcinoma, Tumour biomarkers [more]
Organism: Mouse
Tissue: Liver, Xenograft Tumor
Pathological State: Cancer
Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin
Cell Reports (Cell Press) USA, 01 March 2022
Oncology
Key words: Gα13, KC mouse model, KPC mouse model, Human PDAC tumors, E-cadherin, mTOR, Rapamycin [more]
Organism: Mouse
Tissue: Pancreas
Pathological State: Cancer
Immunoarchitectural patterns as potential prognostic factors for invasive ductal breast cancer
npj Breast Cancer (Nature) China, 28 February 2022
Oncology
Key words: Breast cancer, Prognostic markers [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma
Experimental Cell Research (Elsevier) Austria, 25 February 2022
Oncology
Key words: Mesenchymal-to-epithelial transition, Cell-transfection, TissueFax, UPCI-SCC090, SCC25, FaDu [more]
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus
EBioMedicine (Elsevier) Germany, Austria, 25 February 2022
Neuroscience
Key words: Alzheimer's disease, Plasma extracellular vesicles, Choroid plexus, Hippocampus, Hyaluronan, Hyaluronic acid synthetase, Secretases, BACE, Aβ, APP [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer's disease
Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms
Free Radical Biology and Medicine (Elsevier) China, 24 February 2022
Neuroscience
Key words: Iron, Ischemic stroke, Gliosis, Synaptic plasticity, Myelination, Nerve regeneration [more]
Organism: Mouse
Tissue: Brain
Pathological State: Cerebral Ischemia
Tumor Necrosis Factor-α Mediates Lung Injury in the Early Phase of Endotoxemia
Pharmaceuticals (MDPI) Taiwan, Australia, 24 February 2022
Pulmonology
Key words: lung injury, endotoxin, cytokines, cytokine receptors, peptide, mice [more]
Organism: Mouse
Tissue: Lung
Pathological State: Endotoxemia
Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation
Advanced Biology (Wiley) China, Australia, 23 February 2022
SARS-CoV-2, Osteology
Organism: Human
Pathological State: Covid-19
Cell Line: Bone marrow cells
High farnesoid X receptor expression predicts favorable clinical outcomes in PD‑L1low/negative non‑small cell lung cancer patients receiving anti‑PD‑1‑based chemo‑immunotherapy
International Journal of Oncology (Spandidos Publications) China, 23 February 2022
Oncology
Key words: Farnesoid X receptor, Predictor, anti‑PD‑1‑based, Chemo‑immunotherapy, Non‑small cell lung cancer, PD‑L1low/negative patients [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Prompt Antiviral Action of Pulmonary CD8+ TRM Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung
Frontiers in Immunology (Frontiers Media S.A.) China, 22 February 2022
Immunology
Key words: influenza, lung-resident memory CD8 T cells, IFN-γ, interferon-induced genes, inflammatory cytokines [more]
Organism: Mouse
Tissue: Lung
Pathological State: Influenza Infection