Customer Publications (A total of 2436 papers published)

Inhibition of CDK9 exhibits anticancer activity in hepatocellular carcinoma cells via targeting ribonucleotide reductase

JC Lin, TP Liu, YB Chen, TS Huang, TY Chen, PM Yang

Toxicology and Applied Pharmacology (Elsevier) Taiwan, 27 May 2023

Oncology, Pharmacology

Key words: Cyclin-dependent kinase 9, Hepatocellular carcinoma, Protein degradation, Ribonucleotide reductase [more]

Emodin, a Natural Anthraquinone, Increases Uric Acid Excretion in Rats with Potassium Oxonate-Induced Hyperuricemia

SW Hou, SJ Chen, JD Shen, HY Chen, SJ Wang, CH Wang, KM Man, PL Liu, MY Tsai, YH Chen, WC Chen

Pharmaceuticals (MDPI) Taiwan, 25 May 2023

Toxicology

Key words: uric acid, gout, emodin, potassium oxonate, traditional Chinese medicine, rats [more]

Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats

Y Huang, W Sun, F Gao, H Ma, T Yuan, Z Liu, H Liu, J Hu, J Bai, X Zhang, R Wang

Biology (MDPI) China, 23 May 2023

Neuroscience, Aging

Key words: aromatase, brain-derived estrogen, neurogenesis, gliogenesis, aging [more]

M2e‐specific antibodies protect against influenza PR8 virus in an isotype and route dependent manner

T Sun, Y Wang, P Zou, Q Wang, J Liu, W Liu, J Huang, F Wu

Journal of Medical Virology (Wiley) China, 23 May 2023

Immunology, Virology

Key words: Antibody, influenza A virus, isotype, M2e, protection [more]

Enhancing de novo ceramide synthesis induced by bisphenol A exposure aggravates metabolic derangement during obesity

G Wang, X Hong, J Yu, Y Zhang, Y Li, Z Li, Z Zhu, S Yuan, X Zhang, S Wang, F Zhu, Y Wang, C Wu, P Su, T Shen

Molecular Metabolism (Elsevier) China, UK, 22 May 2023

Endocrinology

Key words: Bisphenol A, ceramide, adipose tissue inflammation, insulin resistance, myriocin [more]

Identification of cervical cancer stem cells using single-cell transcriptomes of normal cervix, cervical premalignant lesions, and cervical cancer

T Zhang, L Zhuang, M Muaibati, D Wang, A Abasi, Q Tong, D Ma, L Jin, X Huang

eBioMedicine (Elsevier) China, 22 May 2023

Stem Cell Research, Oncology

Key words: Cervical cancer, Single-cell RNA sequencing, HSIL, Microinvasive carcinoma of the cervix, Cancer stem cell, Tumor microenvironment [more]

The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage

X Zhu, W Liu, X Tang, Y Chen, X Ge, Q Ke, X Liang, Y Gan, Y Zheng, M Zou, M Deng, Y Liu, DWC Li, L Gong

Journal of Neuroinflammation (Springer) China, 22 May 2023

Ophthalmology

Key words: Retinal degeneration, BET, Neuroinflammation, PROTAC, cGAS-STING, Microglia/macrophage [more]

Increased number and domain of interlaminar astrocytes in layer I of the temporal cortex in epilepsy

N Zhou, Z Fan, Y Tong, X Xiao, Y Xie, Z Qi, L Chen

Neuropathology and Applied Neurobiology (Wiley) China, 20 May 2023

Neuroscience

Key words: Interlaminar astrocytes, Chaslin’s gliosis, Astrocyte domain, Temporal cortex, Epilepsy [more]

APP/PS1 Gene-Environmental Cadmium Interaction Aggravates the Progression of Alzheimer's Disease in Mice via the Blood-Brain Barrier, Amyloid-β, and Inflammation

J Liu, Y Xie, Y Lu, Z Zhao, Z Zhuang, L Yang,, H Huang, H Li, Z Mao, S Pi, F Chen, Y He

Journal of Alzheimer's Disease (IOS Press) China, 20 May 2023

Neuroscience

Key words: Alzheimer’s disease, APP/PS1 gene, blood-brain barrier, cadmium, gene-environment interaction, inflammatory response

Cytolytic CD8+ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes

DR Collins, J Hitschfel, JM Urbach, GH Mylvaganam, NL Ly, U Arshad, ZJ Racenet, AG Yanez, TJ Diefenbach, BD Walker

Science Immunology (Science) USA, Germany, 19 May 2023

Immunology, Virology

[more]

Targeting CD44 variant 5 with an antibody-drug conjugate is an effective therapeutic strategy for intrahepatic cholangiocarcinoma

Y Bei, J He, X Dong, Y Wang, S Wang, W Guo, C Cai, Z Xu, J Wei, B Liu, N Zhang, P Shen

Cancer Research (AACR) China, Ireland, 19 May 2023

Pharmacology, Oncology

Key words: intrahepatic cholangiocarcinoma, CD44 variant 5, antibody-drug conjugate, PDX [more]

Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression-and anxiety-like behavior in mice

R Wang, ZH Liu, N Bi, X Gu, C Huang, R Zhou, H Liu, HL Wang

Ecotoxicology and Environmental Safety (Elsevier) China, 19 May 2023

Neuroscience, Toxicology

Key words: Bisphenol A (BPA), Depression- and anxiety-like behavior, Microglial activation, Neuroinflammation, Medial prefrontal cortex (mPFC) [more]

Following nanoparticle uptake by cells using high-throughput microscopy and the deep-learning based cell identification algorithm Cellpose

B Yang, CJ Richards, TB Gandek, I de Boer, IA Zuazo, E Niemeijer, C Aberg

Frontiers in Nanotechnology (Frontiers Media S.A.) The Netherlands, 18 May 2023

Nanotechnology, Medical Image Analysis

Key words: nanoparticles, cell uptake, fluorescence microscopy, high-throughput, machine learning, image segmentation, modelling, Cellpose [more]

Peptide-Functionalized and Drug-Loaded Tomato Bushy Stunt Virus Nanoparticles Counteract Tumor Growth in a Mouse Model of Shh-Dependent Medulloblastoma

L Marchetti, F Novelli, B Tanno, S Leonardi, VM Hizam, C Arcangeli, L Santi, S Baschieri, C Lico, M Mancuso

International Journal of Molecular Sciences (MDPI) Italy, 17 May 2023

Pharmacology, Oncology

Key words: TBSV NPs, drug delivery system, doxorubicin, preclinical study, Ptch1+/− mice, MB therapy [more]

Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma

Y Wang, X Xiang, H Chen, L Zhou, S Chen, G Zhang, X Liu, X Ren, J Liu, M Kuang, J Jiang, J She, Z Zhang, R Xue, H Jiang, J Wang, S Peng

Cell Reports Medicine (Cell Press) China, 16 May 2023

Immunology, Oncology

[more]

Effects of Therapeutic Hypothermia on Macrophages in Mouse Cochlea Explants

W Bader, C Steinacher, HT Fischer, R Glueckert, J Schmutzhard, A Schrott-Fischer

International Journal of Molecular Sciences (MDPI) Austria, 16 May 2023

Otolaryngology

Key words: cochlea implant, IBA1, F4/80, CD163, CD45, immune response, inner ear, hypothermia [more]

Short‐term toll‐like receptor 9 inhibition leads to left ventricular wall thinning after myocardial infarction

M Lenz, A Kiss, P Haider, M Salzmann, M Brekalo, KA Krychtiuk, O Hamaza, K Huber, C Hengstenberg, BK Podesser, J Wojta, PJ Hohensinner, WS Speidl

ESC Heart Failure (Wiley) Austria, 16 May 2023

Pharmacology, Cardiology

Key words: CXCR2, Infarction, Ischaemia–reperfusion, Neutrophils, TLR9 [more]

Characterization of Early and Late Damage in a Mouse Model of Pelvic Radiation Disease

R Vitali, F Palone, I De Stefano, C Fiorente, F Novelli, E Pasquali, E Fratini, M Tanori, S Leonardi, B Tanno, E Colantoni, S Soldi, S Galletti, M Grimaldi, AG Morganti, L Fuccio, S Pazzaglia, C Pioli, M Mancuso, L Vesci

International Journal of Molecular Sciences (MDPI) Italy, 15 May 2023

Radiotherapy

Key words: mouse model, intestinal damage, ionizing radiation, intestinal stem cells, fecal markers [more]

Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-κB signaling pathway activation in aged mice

Y Yao, D Lin, Y Chen, L Liu, Y Wu, X Zheng

Inflammation Research (Springer) China, 15 May 2023

Aging

Key words: Microglia, Neuroinflammation, Postoperative cognitive dysfunction, Fluoxetine, Toll-like receptor 4 [more]

Inactivation of EGFR/ERK/NF‐κB signalling associates with radiosensitizing effect of 18β‐glycyrrhetinic acid on progression of hepatocellular carcinoma

YC Liu, CH Lin, KT Chen, DW Lai, FT Hsu

Journal of Cellular and Molecular Medicine (Wiley) Taiwan, 12 May 2023

Oncology

Key words: 18β- Glycyrrhetinic acid, epidermal growth factor receptor, ERK, hepatocellular carcinoma, NF-κB, radiotherapy [more]

Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice

C Wang, B Zhao, J Zhai, A Wang, N Cao, T Liao, R Su, L He, Y Li, X Pei, Y Jia, W Yue

Cell Death & Disease (Nature) China, 12 May 2023

Stem Cell Research

Key words: Mesenchymal stem cells, Stem-cell research [more]

Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity

M Cui, Q He, Z Wang, Y Yu, H Gao, Z Liu, H Peng, H Wang, X Zhang, D Li, L Chen, X Xing, Y Xiao, W Chen, Q Wang

Environmental Pollution (Elsevier) China, 12 May 2023

Gastroenterology

Key words: Nanoplastics, Intestinal barrier, Tight junction protein, Mucin2, IL-10 [more]

Stromal and intratumoral T cell infiltration in head and neck squamous cell carcinoma

D Krum, S Rösch, G Dyckhoff, R Warta, PK Plinkert, C Herold-Mende

Laryngo-Rhino-Otologie (thieme-connect.com) Germany, 12 May 2023

Immunology, Oncology

[more]

Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study

TC Lin, YC Tsai, YA Chen, TH Young, CC Wu, YH Chiang, CH Kao, APH Huang, KY Chen, LK Tsai

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) Taiwan, 11 May 2023

Neuroscience

Key words: cerebrospinal fluid, intracerebral hemorrhage (ICH), neurogenesis, subventricular zone (SVZ), brain-derived neurotrophic factor (BDNF) [more]

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8+ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

A Rezapour, D Rydbeck, F Byvald, V Tasselius, G Danielsson, E Angenete, U Yrlid

OncoImmunology (Taylor & Francis) Sweden, 10 May 2023

Immunology, Oncology

Key words: Granzyme B, γδ T cells, Immunoscore, Type I Interferon, MxA, Neoadjuvant treatment, Rectal Cancer, Tumor infiltrating lymphocytes [more]

Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancer

AL Berr, K Wiese, G Dos Santos, CM Koch, KR Anekalla, M Kidd, JM Davis, Y Cheng, YS Hu, KM Ridge

Oncogene (Nature) USA, 09 May 2023

Oncology

Key words: Cell death, Intermediate filaments, Non-small-cell lung cancer [more]

Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain

CY Ding, YT Ding, H Ji, YY Wang, X Zhang, DM Yin

Cell & Bioscience (BMC) China, 05 May 2023

Neuroscience

Key words: Neuregulin 1, Cre-reporting mice, Olfactory bulb, Striatum, Cerebral cortex, Hippocampus, Hypothalamus, cerebellum, axon projection [more]

Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC

M Li, L Duan, W Wu, W Li, L Zhao, A Li, X Lu, X He, Z Dong, K Liu, Y Jiang

Oncogenesis (Nature) China, 05 May 2023

Oncology

Key words: Cancer prevention, Oesophageal cancer, Target identification, Target validation [more]

Renewal of Oligodendrocyte Lineage Reverses Dysmyelination and CNS Neurodegeneration Through Corrected N-acetylaspartate Metabolism

A Lotun, D Li, H Xu, Q Su, S Tuncer, J Sanmiguel, M Mooney, CE Baer, R Ulbrich, SJ Eyles, L Strittmayer, LJ Hayward, DJ Gessler

Progress in Neurobiology (Elsevier) USA, China, Germany, 04 May 2023

Neuroscience

Key words: CNS, Neurodegeneration, Demyelination, Gene therapy, AAV, Canavan disease, N-acetylaspartate, Oligodendrocytes, Neurons [more]

Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis

T Zhou, Y Xie, X Hou, W Bai, X Li, Z Liu, Q Man, J Sun, D Fu, J Yan, Z Zhang, Y Wang, H Wang, W Jiang, S Gao, T Zhao, A Chang, X Wang, H Sun, X Zhang, S Yang, C Huang, J Hao, J Liu

Journal of Experimental & Clinical Cancer Research (BMC) China, USA, 04 May 2023

Oncology

Key words: Pancreatic cancer, Organoids, High-throughput drug screening, c-Jun, Irbesartan [more]

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

L Chibaya, KC Murphy, KD DeMarco, S Gopalan, H Liu, CN Parikh, Y Lopez-Diaz, M Faulkner, J Li, JP Morris IV, YJ Ho, SK Chana, J Simon, W Luan, A Kulick, E de Stanchina, K Simin, LJ Zhu, TG Fazzio, SW Lowe, M Ruscetti

Nature Cancer (Nature) USA, 04 May 2023

Oncology

Key words: Cancer, Immunosurveillance, Pancreatic cancer, Senescence, Targeted therapies [more]

The ICAM-1 ligand HRV-A89 is internalized independently of clathrin-mediated endocytosis and its capsid reaches late endosomes

B Pfanzagl

Virology (Elsevier) Austria, 03 May 2023

Cell Biology

Key words: Arf6, Chlorpromazine, Endocytosis, ICAM-1, Imipramine, Rhinovirus [more]

Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer

M Wang, CA Wisniewski, C Xiong, P Chhoy, HL Goel, A Kumar, LJ Zhu, R Li, PA St.Louis, LM Ferreira, H Pakula, Z Xu, M Loda, Z Jiang, MA Brehm, AM Mercurio

Science Translational Medicine (Science) USA, 03 May 2023

Immunology, Oncology

[more]

Androgen therapy does not prevent bone loss and arterial calcifications in male rats with chronic kidney disease

K David, V Dubois, A Verhulst, V Sommers, V Sommers, D Schollaert, L Deboel, K Moermans, G Carmeliet, P D’Haese, D Vanderschueren, F Claessens, P Evenepoel, B Decallonne , D Schollaert , L Deboel , K Moermans , G Carmeliet , P D’Haese , D Vanderschueren V Sommers , D Schollaert , L Deboel , K Moermans , G Carmeliet , P D’Haese , D Vanderschueren , F Claessens , P Evenepoel , and B Decallonne

Journal of Endocrinology (Society for Endocrinology) Belgium, 02 May 2023

Endocrinology, Hepathology

Key words: androgen replacement therapy, chronic kidney disease, hypogonadism, bone loss, arterial calcification [more]

Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses

MM Pillat, AC Ayupe, G Juvenal, C Meinerz, T Glaser, D Vieira da Silva Pellegrina, D Souza Paiva, CF Mello, B Monteiro Longo, E Moraes Reis, H Ulrich

Stem Cell Reviews and Reports (Springer) Brazil, 02 May 2023

Immunology, Neuroscience

Key words: Neural progenitor cells, Cytokines, Degenerative disease, Neural development, Neuroinflammation [more]

Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain

E Stroo, L Janssen, O Sin, W Hogewerf, M Koster, L Harkema, SA Youssef, N Beschorner, AHG Wolters, B Bakker, L Becker, Lilian Garrett, S Marschall, SM Hoelter, W Wurst, H Fuchs, V Gailus-Durner, M Hrabe de Angelis, A Thathiah, F Foijer, B van de Sluis, J van Deursen, M Jucker, A de Bruin, EAA Nollen

Life Science Alliance (Life Science Alliance) The Netherlands, Portugal, Germany, Belgium, USA, 02 May 2023

Neuroscience, Developmental Biology

[more]

Reshaping fish intestinal microbiota and facilitating barrier function by ZnO nanoparticles

S Ma, WX Wang

Environmental Science: Nano (Royal Society of Chemistry) China, 01 May 2023

Nanomedicine, Zoology

[more]

Therapeutic efficacy of a MMAE-based anti-DR5 drug conjugate Oba01 in preclinical models of pancreatic cancer

C Zheng, D Zhou, W Li, Y Duan, M Xu, J Liu, J Cheng, Y Xiao, H Xiao, T Gan, J Liang, D Zheng, L Wang, S Zhang

Cell Death & Disease (Nature) China, 29 April 2023

Oncology, Pharmacology

Key words: Preclinical research, Targeted therapies [more]

Expression-based subtypes define pathologic response to neoadjuvant immune-checkpoint inhibitors in muscle-invasive bladder cancer

AG Robertson, K Meghani, LF Cooley, KA McLaughlin, LA Fall, Z Yu, MA Castro, CS Groeneveld, A de Reyniès, VI Nazarov, VO Tsvetkov, B Choy, D Raggi, L Marandino, F Montorsi, T Powles, A Necchi, JJ Meeks

Nature Communications (Nature) Canada, USA, Brazil, France, USA, Italy, UK, 27 April 2023

Oncology

Key words: Bladder cancer, Tumour immunology [more]

Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms

YT Magalhaes, VK Boell, GD Cardella, FL Forti

Cell Death & Disease (Nature) Brazil, 21 April 2023

Oncology

Key words: Cytoskeleton, DNA damage and repair [more]

Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma

TY Hsieh, WW Sung, YC Chang, CY Yu, LY Lu, C Dong, TH Lee, SL Chen

Aging (Albany NY) (ncbi.nlm.nih.gov) Taiwan, 21 April 2023

Pharmacology, Oncology

Key words: melatonin, bladder cancer, apoptosis, NF-κB, HIF-1α [more]

BiTE‐Secreting CAR‐γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors

SW Huang, CM Pan, YC Lin, MC Chen, Y Chen, CI Jan, CC Wu, FY Lin, ST Wang, CY Lin, WH Huang, YT Chiang, WC Tsai, YH Chiu, TH Lin, SC Chiu, DY Cho

Advanced Science (Wiley) Taiwan, 20 April 2023

Oncology, Pharmacology

[more]

Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

O Leddy, FM White, BD Bryson

Elife (eLife Sciences Publications) USA, 19 April 2023

Immunology, Virology

[more]

BushenHuoxue decoction suppresses M1 macrophage polarization and prevents LPS induced inflammatory bone loss by activating AMPK pathway

S Chen, L Tao, F Zhu, Z Wang, Q Zhuang, Y Li, Y Yang, C Feng, H Shi, J Shi, L Zhu, L Xiao, D Geng, Z Wang

Heliyon (Cell Press) China, 19 April 2023

Immunology

Key words: Inflammatory bone loss, Bushen huoxue decoction, Inflammation, Macrophage polarization, Bone immune regulation [more]

Targeting YAP1 ameliorates progesterone resistance in endometriosis

SC Lin, WN Li, SC Lin, HT Hou, YC Tsai, TC Lin, MH Wu, SJ Tsai

Human Reproduction (Oxford Academic) Taiwan, 18 April 2023

Reproductive Medicine

Key words: YAP1, miR-21-5p, PGR, progesterone resistance, endometriosis [more]

Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity

VA Onofrei, E Anisie, CL Zamfir, A Ceasovschih, M Constantin, F Mitu, ED Grigorescu, AD Petroaie, DV Timofte

Journal of Clinical Medicine (MDPI) Romania, 14 April 2023

Endocrinology, Oncology

Key words: arterial stiffness, adipokines, morbid obesity, cardiovascular risk, perivascular adipose tissue [more]

Single-cell transcriptome analysis revealed the immune profile of PD-1 blockade in gallbladder carcinoma liver metastasis

L Xie, Z Ning, Y Hua, P Wang, Z Meng

Hepatology Communications (Wiley) China, 14 April 2023

Oncology

[more]

Upregulation of dendrocyte-expressed seven transmembrane protein is associated with unfavorable outcomes in differentiated thyroid cancer

JJ Lee, YC Hsu, WC Huang, SP Cheng

Endocrine (Springer) Taiwan, 14 April 2023

Oncology, Pharmacology

Key words: DCSTAMP, Recurrence, Survival, Thyroid cancer, Immunohistochemistry [more]

The effects of mild hypothermia on the electrode insertion trauma in a murine whole organ cochlea culture

J Schmutzhard, W Bader, T Gottfried, D Dejaco, R Glückert, J Dudas, A Schrott-Fischer

Frontiers in Neuroscience (Frontiers Media S.A.) Austria, 13 April 2023

Pathology

Key words: hypothermia, whole organ cochlea culture, electrode insertion trauma, cochlear implant, sensorineural hearing loss, hearing rehabilitation [more]

Yellow mealworm (Tenebrio Molitor) enhances intestinal immunity in largemouth bass (Micropterus salmoides) via the NFκB/survivin signaling pathway

C Ge, X Liang, X Wu, J Wang, H Wang, Y Qin, M Xue

Fish & Shellfish Immunology (Elsevier) China, 11 April 2023

Zoology

Key words: Yellow mealworm, Largemouth bass, Intestinal immunity, NFκBp65, Survivin [more]

Axonal mapping of motor and sensory components within the ulnar nerve and its branches

V Tereshenko, U Maierhofer, LA Hruby, J Klepetko, DC Dotzauer, O Politikou, G Laengle, M Luft, C Festin, R Blumer, KD Bergmeister, OC Aszmann

Journal of Neurosurgery (American Association of Neurological Surgeons) Austria, 07 April 2023

Neuroscience

Key words: axon count, flexor carpi ulnaris muscle, flexor digitorum profundus muscle, nerve transfer, deep branch of the ulnar nerve, superficial branch of the ulnar nerve, peripheral nerve, anatomy [more]

Prognostic values of tissue-resident CD8+ T cells in human hepatocellular carcinoma and intrahepatic cholangiocarcinoma

L Chen, H Huang, Z Huang, J Chen, Y Liu, Y Wu, A Li, J Ge, Z Fang, B Xu, X Zheng, C Wu

World Journal of Surgical Oncology (BMC) China, 06 April 2023

Oncology

Key words: Hepatocellular carcinoma, Intrahepatic Cholangiocarcinoma, Multicolor immunohistochemistry, Prognosis, Tissue-resident CD103+CD8+T cells [more]

Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia

Q Jiang, J Stachelscheid, J Bloehdorn, A Pacholewska, C Markus A, F Grotenhuijs, TA Müller, O Onder, P Wagle, CD Herling, M Kleppe, Z Wang, KR Coombes, S Robrecht, PS Dalvi, BA Lungu, P Mayer, LV Abruzzo, J Altmüller, BS Gathof, T Persigehl, K Fischer, BMC Jebaraj, H Young Rienhoff Jr, RC Ecker, Y Zhao, CJ Bruns, S Stilgenbauer, KSJ Elenitoba-Johnson, M Hallek, MR Schweiger, M Odenthal, E Vasyutina, M Herling

Blood (ASH Publications) Germany, USA, China, Romania, Austria, Australia, 06 April 2023

Oncology

Key words: chronic lymphocytic leukemia, TCL1A, KDM1A, epigenetics, histone modulation [more]

Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis

N Das, LGN de Almeida, A Derakhshani, D Young, K Mehdinejadiani, P Salo, A Rezansoff, GD Jay, CP Sommerhoff, TA Schmidt, R Krawetz, A Dufour

Nature Communications (Nature) Canada, USA, Germany, 06 April 2023

Osteology

Key words: Biochemical networks, Proteases, Proteolysis, Rheumatology [more]

Neuroprotective effects of resistance physical exercise on the APP/PS1 mouse model of Alzheimer's disease

HC Campos, DE Ribeiro, D Hashiguchi, DY Hukuda, C Gimenes, D Suchecki, RM Arida, H Ulrich, B Monteiro Longo

Frontiers in Neuroscience (Frontiers Media S.A.) Brazil, 06 April 2023

Pharmacology, Neuroscience

Key words: Alzheimer’s disease, resistance exercise, locomotor activity, corticosterone, amyloid-beta precursor protein [more]

Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma

T Zhou, Q Man, X Li, Y Xie, X Hou, H Wang, J Yan, X Wei, W Bai, Z Liu, J Liu, J Hao

Cancer Biology & Medicine (China Anti-Cancer Association) China, 05 April 2023

Oncology, Machine Learning

Key words: Artificial intelligence, CD8, CSCs, tumor budding, PDAC, nomogram [more]

Hypoxia switches TET1 from being tumor-suppressive to oncogenic

Q Yang, H Dang, J Liu, X Wang, J Wang, X Lan, M Ji, M Xing, P Hou

Oncogene (Nature) China, 05 April 2023

Oncology

Key words: Cancer microenvironment, Oncogenes [more]

Molecules of senescent glial cells differentiate Alzheimer's disease from ageing

L Dai, F Gao, Q Wang, X Lv, Z Cheng, Y Wu, X Chai, H Zetterberg, K Blennow, AI Levey, J Shi, Y Shen

Journal of Neurology, Neurosurgery & Psychiatry (BMJ Journals) China, Sweden, UK, USA, 04 April 2023

Neuroscience

[more]

Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses

Q Zeng, S Wang, M Li, S Wang, C Guo, X Ruan, R Watanabe, Y Lai, Y Huang, X Yin, C Zhang, B Chen, N Yang, H Zhang

Cell Metabolism (Cell Press) China, Japan, 04 April 2023

Immunology

Key words: CD36, acetylcholine, autoreactive B cell responses, choline acetyltransferase, fibroblastic reticular cells, lipid metabolism, mitochondrial respiration, spleen, systemic lupus erythematosus [more]

Red blood cell extracellular vesicles deliver therapeutic siRNAs to skeletal muscles for treatment of cancer cachexia

B Peng, Y Yang, Z Wu, R Tan, TT Pham, EYM Yeo, M Pirisinu, MK Jayasinghe, TC Pham, K Liang, N Shyh-Chang, MTN Le

Molecular Therapy (Cell Press) Singapore, China, 04 April 2023

Oncology

Key words: extracellular vesicles, cancer cachexia, siRNA, RNA delivery, myostatin, malonyl-CoA decarboxylase [more]

Characterization and Advancement of an Evaluation Method for the Treatment of Spontaneous Osteoarthritis in STR/ort Mice: GRGDS Peptides as a Potential Treatment for Osteoarthritis

MF Chen, CC Hu, YH Hsu, YT Chiu, KL Chen, SWN Ueng, Y Chang

Biomedicines (MDPI) Taiwan, 02 April 2023

Osteology

Key words: Osteoarthritis, STR/ort, cartilage, matrix metallopeptidase-13, SRY-box transcription factor 91 [more]

A Deep-Learning-Computed Cancer Score for the Identification of Human Hepatocellular Carcinoma Area Based on a Six-Colour Multiplex Immunofluorescence Panel

A Dievernich, J Stegmaier, P Achenbach, S Warkentin, T Braunschweig, UP Neumann, U Klinge

Cells (MDPI) Germany, The Netherlands, 02 April 2023

Osteology, Machine Learning

Key words: hepatocellular carcinoma, HCC, convolutional neural network, CNN, U-net, multiplex, fluorescence, immunofluorescence, microscopy, cancer score [more]

Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue

N Chen, M Yuan, NN Zhang, M Chen, R Liu, J Wang, P Lu

iScience (Cell Press) China, 01 April 2023

Cell Biology

Key words: β-catenin, UCP1, thermogenesis, beige adipocytes, energy expenditure [more]

Analysis of Single-and Double-Stranded DNA Damage in Osteoblastic Cells after Hyperbaric Oxygen Exposure

N Schönrock, F Tillmans, S Sebens, W Kähler, S Klapa, B Rieger, H Scherthan, A Koch

Antioxidants (MDPI) Germany, USA, 01 April 2023

Osteology

Key words: oxidative stress, DNA damage, osteoblasts, gamma-H2AX, hyperbaric hyperoxia, comet assay, DSBs [more]

High bacillary burden and the ESX-1 type VII secretion system promote MHC class I presentation by Mycobacterium tuberculosis infected macrophages to CD8 T-cells

D Mott, J Yang, C Baer, K Papavinasasundaram, CM Sassetti, SM Behar

The Journal of Immunology (AHA Journals) USA, 31 March 2023

Immunology, Microbiology

DARPP‐32 cells and neuropil define striosomal system and isolated matrix cells in human striatum

CJ Arasaratnam, JJ Song, T Yoshida, MA Curtis, AM Graybiel, RLM Faull, HJ Waldvogel

Journal of Comparative Neurology (Wiley) New Zealand, USA, 31 March 2023

Neuroscience

Key words: DARPP-32, spinyprojectionneurons, striatum, striosomes [more]

Optimizing culturing conditions in patient derived 3D primary slice cultures of head and neck cancer

M do Carmo Greier, A Runge, J Dudas, L Carpentari, VH Schartinger, A Randhawa, M Mayr, M Petersson, H Riechelmann

Frontiers in Oncology (Frontiers Media S.A.) Austria, 30 March 2023

Biological Methods, Oncology

Key words: head and neck cancer, tumor microenvironment, cultured neoplastic cells, platelet rich fibrin, culture media [more]

Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy

T Dong, ZQ Zhang, LH Sun, W Zhang, Z Zhu, L Lin, Lin Yang, A Lv, C Liu, Q Li, RF Yang, X Zhang, Y Niu, HZ Chen, DP Liu, WM Tong

Brain Pathology (Wiley) China, 28 March 2023

Neuroscience

Key words: antioxidant, Mic60, mitochondria, mitochondrial encephalomyopathies, neurodegeneration, reactive oxygen species [more]

CD226 identifies functional CD8+ T cells in the tumor microenvironment and predicts a better outcome for human gastric cancer

H Huang, Z Huang, J Ge, J Yang, J Chen, B Xu, S Wu, X Zheng, L Chen, X Zhang, J Jiang

Frontiers in Immunology (Frontiers Media S.A.) China, 28 March 2023

Oncology, Gastroenterology

Key words: CD226, CD8+ T cells, multi-color immunohistochemical staining, prognosis, gastric cancer [more]

Protective effects of resveratrol on the ethanol‐induced disruption of retinogenesis in pluripotent stem cell‐derived organoids

H Li, L Gao, Z Ye, J Du, W Li, L Liang, Q Zeng, J Xi, W Yue, Z Li

FEBS Open Bio (Wiley) China, 27 March 2023

Ophthalmology

Key words: ethanol, fetal alcohol syndrome, PI3K-AKT signalling, resveratrol, retinal organoids [more]

Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages

X Li, X Chen, S Gong, J Zhao, C Yao, H Zhu, R Xiao, Y Qin, R Li, N Sun, X Li, F Dong, T Zhao, Y Pan, J Yang

Theranostics (Ivyspring International Publisher) China, 27 March 2023

Immunology, Oncology

Key words: Platelets, TAMs, CRC, PSGL-1/JNK/STAT1, C5a/C5aR1 [more]

Functional Peptide-Loaded Gelatin Nanoparticles as Eyedrops for Cornea Neovascularization Treatment

YC Chu, HW Fang, YY Wu, YJ Tang, EH Hsieh, Y She, CY Chang, IC Lin, YJ Chen, GS Liu, CL Tseng

International Journal of Nanomedicine (Taylor & Francis) Taiwan, Australia, 23 March 2023

Nanomedicine, Ophthalmology

Key words: gp91 peptide, gelatin, nanoparticles, ocular retention, control release, corneal neovascularization, eye drops [more]

Occurrence, risk assessment, and in vitro and in vivo toxicity of antibiotics in surface water in China

C Zhang, Y Chen, S Chen, X Guan, Y Zhong, Q Yang

Ecotoxicology and Environmental Safety (Elsevier) China, 22 March 2023

Toxicology, Ecology

Key words: Antibiotics, Environmental pollution, Surface water, Intestinal flora, Oxidative stress [more]

Dual-Ratiometric Magnetic Resonance Tunable Nanoprobe with Acidic-microenvironment-responsive Property to Enhance the Visualization of Early Tumor Pathological Changes

R Cao, N Tang, Y Zhu, A Chen, Y Li, R Ge, Y Li, Z Huang, J Guo, J Deng, H Lu, Z Lu, H Forgham, TP Davis, R Qiao, Z Wang

Nano Research (Sciopen) China, USA, Australia, 22 March 2023

Nanomedicine, Oncology

Key words: ratiometric nanoprobe, dually activatable, microenvironment visualization, early diagnosis, pathological changes [more]

Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy

GS Dunlap, D DiToro, J Henderson, SI Shah, M Manos, M Severgnini, A Weins, I Guleria, PA Ott, N Murakami, DA Rao

Nature Communications (Nature) USA, 21 March 2023

Immunology, Transplantation Medicine

Key words: Graft-versus-host disease, Immunotherapy, Kidney, Transplant immunology, Tumour immunology [more]

Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization

D Chen, N Hu, S Xing, L Yang, F Zhang, S Guo, S Liu, X Ma, X Liang, H Ma

Journal of Ovarian Research (BMC) China, 21 March 2023

Reproductive Medicine

Key words: Placental mesenchymal stem cells, Premature ovarian insufficiency, Macrophage, Inflammasome, NLRP3, Interferon-γ, Pyroptosis [more]

Analysis of the Mechanism Underlying Diabetic Wound Healing Acceleration by Calycosin-7-glycoside Using Network Pharmacology and Molecular Docking

J Chen, H Ma, Y Meng, Q Liu, Y Wang, Y Lin, D Yang, W Yao, Y Wang, X He, P Li

Phytomedicine (Elsevier) China, 20 March 2023

Pharmacology

Key words: Diabetic wound healing, Calycosin-7-glucoside, Mitochondrial metabolism, Macrophage polarization, Network pharmacology, Molecular docking [more]

Intrinsic RIG-I restrains STAT5 activation to modulate anti-tumor activity of CD8+ T cells

X Jiang, J Lin, C Shangguan, X Wang, B Xiang, J Chen, H Guo, W Zhang, J Zhang, Y Shi, J Zhu, H Yang

The Journal of Clinical Investigation (American Society for Journal of Clinical Investigation) China, 16 March 2023

Immunology, Oncology

Key words: RIG-I, Tumor-infiltrating CD8+ , T cell, STAT5 activation, Colon cancer [more]

Fast and sensitive GCaMP calcium indicators for imaging neural populations

Y Zhang, M Rózsa, Y Liang, D Bushey, Z Wei, J Zheng, D Reep, GJ Broussard, A Tsang, G Tsegaye, S Narayan, CJ Obara, JX Lim, R Patel, R Zhang, MB Ahrens, GC Turner, SSH Wang, WL Korff, ER Schreiter, K Svoboda, JP Hasseman, I Kolb, LL Looger

Nature (Nature) USA, 15 March 2023

Neuroscience

Key words: Fluorescent proteins, Neural circuits [more]

Thorium (IV) Triggers Ferroptosis through Disrupting Iron Homeostasis and Heme Metabolism in the Liver Following Oral Ingestion

M Ma, R Wang, M Xu

Journal of Hazardous Materials (Elsevier) China, 15 March 2023

Hepathology

Key words: Thorium, Hepatotoxicity, Ferroptosis, Iron homeostasis, Heme metabolism [more]

Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer

Z Valko, Z Megyesfalvi, A Schwendenwein, C Lang, S Paku, N Barany, B Ferencz, A Horvath-Rozsas, I Kovacs, E Schlegl, V Pozonec, K Boettiger, M Rezeli, G Marko-Varga, F Renyi-Vamos, M Alireza Hoda, T Klikovits, K Hoetzenecker, Michael Grusch, V Laszlo, B Dome, K Schelch

British Journal of Cancer (Nature) Austria, Hungary, Sweden, 14 March 2023

Oncology

Key words: Small-cell lung cancer [more]

Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma

J Chen, K Liu, Y Luo, M Kang, J Wang, G Chen, J Qi, W Wu, B Wang, Y Han, L Shi, K Wang, X Han, X Ma, W Liu, Y Ding, L Wang, H Liang, L Wang, J Chen

Gastroenterology (Elsevier) China, USA, 14 March 2023

Oncology

Key words: Gastric Cancer, T-Cell State, CXCL13, Immune Checkpoint Blockade [more]

Expression of Checkpoint Molecules in the Tumor Microenvironment of Intrahepatic Cholangiocarcinoma: Implications for Immune Checkpoint Blockade Therapy

L Heij, J Bednarsch, X Tan, M Rosin, S Appinger, K Reichel, D Pecina, M Doukas, RM Van Dam, J Garcia Vallejo, F ulmer, S Lang, T Luedde, FG Rocha, S Sivakumar, UP Neumann

Cells (MDPI) Germany, The Netherlands, USA, UK, 09 March 2023

Oncology, Immunology

Key words: cholangiocarcinoma, tumor microenvironment, checkpoint molecules, multiplexed imaging, immunotherapy [more]

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

VN Hariharan, M Shin, CW Chang, D O'Reilly, A Biscans, K Yamada, Z Guo, M Somasundaran, Q Tang, K Monopoli, PM Krishnamurthy, G Devi, N McHugh, DA Cooper, D Echeverria, J Cruz, IL Chan, P Liu, SY Lim, J McConnell, S Prakash Singh, S Hildebrand, J Sousa, SM Davis, Z Kennedy, C Ferguson, BMD Godinho, Y Thillier, J Caiazzi, S Ly, M Muhuri, K Kelly, F Humphries, A Cousineau, KM Parsi, Q Li, Y Wang, R Maehr, G Gao, D Korkin, WM McDougall, RW Finberg, KA Fitzgerald, JP Wang, JK Watts, A Khvorova

PNAS (Proceedings of the National Academy of Sciences of the United States of America) USA, 09 March 2023

SARS-CoV-2, Immunology

Key words: SARS-COV-2, antisense oligos, small interfering RNAs, mouse model, lung [more]

Effects of paraprobiotics on bile acid metabolism and liver health in largemouth bass (Micropterus salmoides) fed a cottonseed protein concentrate-based diet

X Xie, X Liang, H Wang, Q Zhu, J Wang, Y Chang, E Leclercq, M Xue, J Wang

Animal Nutrition (Elsevier) China, France, 07 March 2023

Zoology

Key words: Cottonseed protein concentrate, Multi-yeast strain fractions, Micropterus salmoides, Liver health, Bile acid metabolism, Gut microbiota [more]

In Situ Formation of Injectable Gelatin Methacryloyl (GelMA) Hydrogels for Effective Intraocular Delivery of Triamcinolone Acetonide

C Shen, X Zhao, Z Ren, B Yang, X Wang, A Hu, J Hu

International Journal of Molecular Sciences (MDPI) China, 04 March 2023

Pharmacology

Key words: gelatin methacryloyl, triamcinolone acetonide, retina hydrogel system, hydrogel drug release, intraocular drug delivery, injectable gel [more]

Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration

LW Lin, SW Wang, WC Huang, TK Huynh, CY Lai, CY Ko, YC Fong, JJ Lee, SF Yang, CH Tang

Cells (MDPI) Taiwan, 03 March 2023

Aging

Key words: melatonin, endothelial progenitor cells, vascular endothelial growth factor (VEGF), platelet-derived growth factor-BB (PDGF-BB), angiogenesis, neovascular age-related macular degeneration [more]

The protective effect of cannabinoids against colorectal cancer cachexia through modulation of inflammation and immune responses

SK Ng, DJ Chung, LC Chang, CK Luo, SH Jwo, YH Lee, JS Lin, CH Wang, TT Wei

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 03 March 2023

Immunology, Oncology

Key words: Colorectal cancer cachexia, Cytokines, Cannabinoids, CD8+ T cell, Cannabinoid receptor 2 [more]

miR-194 upregulates CYP7A1 expression via β-catenin signaling and aggravates cholestatic liver diseases

PC Chen, CP Hsu, SY Wang, TY Wu, YJ Lin, YT Chen, SH Hsu

The American Journal of Pathology (Elsevier) Taiwan, 02 March 2023

Hepathology

[more]

Androgen therapy does not prevent bone loss and arterial calcifications in male rats with CKD

K David, V Dubois, A Verhulst, V Sommers, D Schollaert, L Deboel, K Moermans, G Carmeliet, P D'Haese, D Vanderschueren, F Claessens, P Evenepoel, B Decallonne

Journal of Endocrinology (Society for Endocrinology) Belgium, 01 March 2023

Endocrinology

Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells

MQ Yan, Y Wang, Z Wang, XH Liu, YM Yang, XY Duan, H Sun, XM Liu

Journal of the Endocrine Society (Oxford Academic) China, 28 February 2023

Oncology

Key words: mitochondrial fusion, testosterone, granulosa cells, steroidogenic acute regulatory protein, sex hormones, polycystic ovary syndrome [more]

Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo

P Strasser, B Montsch, S Weiss, H Sami, C Kugler, S Hager, H Schueffl, R Mader, O Brüggemann, CR Kowol, M Ogris, P Heffeter, I Teasdale

Small (Wiley) Austria, 26 February 2023

Nanomedicine

Key words: biodistribution, bottlebrush polymers, nanomedicine, pharmacokinetics, polyglutamate, polymer therapeutics, polyphosphazenes [more]

Electrical Sympathetic Neuromodulation Protects Bone Marrow Niche and Drives Hematopoietic Regeneration during Chemotherapy

YT Hsu, LH Chen, YH Liu, SK Chu, TY Chen, KJ Tsai, MR Shen, W Liu

Small Methods (Wiley) Taiwan, USA, 26 February 2023

Neuroscience

Key words: bone marrow niche, chemotherapy-induced nerve damage, electrical neuromodulation, hematopoiesis [more]

Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke

H Zheng, X Guo, S Kang, Z Li, T Tian, J Li, F Wang, P Yu, S Chang, YZ Chang

Cell Death & Disease (Nature) China, 25 February 2023

Neuroscience

Key words: Stroke [more]

Transgenic HPV11-E2 protein modulates URR activity in vivo

S Wang, V Gramm, E Laport, T Holland-Letz, A Alonso, J Schenkel

Transgenic Research (Springer) Germany, 24 February 2023

Virology

Key words: HPV-E2, Human papillomavirus type 11, Reporter gene, Transgenic mouse model, Upstream regulatory region URR [more]

Immune Microenvironment in Sporadic Early-Onset versus Average-Onset Colorectal Cancer

F Andric, A Al-Fairouzi, Y Wettergren, L Szeponik, E Bexe-Lindskog, JC Cusack Jr, G Tumusiime, M Quiding-Järbrink, D Ljungman

Cancers (MDPI) Sweden, USA, Uganda, 24 February 2023

Oncology

Key words: early-onset colorectal cancer, tumor microenvironment, tumor-infiltrating lymphocytes, gene expression, immunofluorescence [more]

UHRF1/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer

S Lin, H Xu, L Qin, M Pang, Z Wang, M Gu, L Zhang, C Zhao, X Hao, Z Zhang, W Ding, J Ren, J Huang

Acta Pharmaceutica Sinica B (Elsevier) China, 24 February 2023

Oncology

Key words: Lung cancer, Intratumor heterogeneity, Splice variants, Intragenic CpG methylation, Protease serine 3, Myeloid zinc finger 1, UHRF1/DNMT1, 5-Aza-CdR [more]

Poly (I: C) Exacerbates Airway Goblet Cell Hyperplasia and Lung Inflammation in HDM-Exposed Balb/C Mice by YAP/FOXM1 Pathway

ML Bu, MH Li, M Feng, JR Wang, L Sun

International Archives of Allergy and Immunology (Karger) China, 23 February 2023

Immunology

Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging

VA Onofrei, CL Zamfir, E Anisie, A Ceasovschih, M Constantin, F Mitu, CA Adam, ED Grigorescu, AD Petroaie, D Timofte

Medicina (MDPI) Romania, 22 February 2023

Cardiology

Key words: arterial stiffness, cardiovascular risk, morbid obesity, pulse wave analysis, adiponectin, chemerin, adipocyte [more]

Oolong tea of different years protects high-fat diet-fed mice against obesity by regulating lipid metabolism and modulating gut microbiota

WW Fang, KF Wang, F Zhou, J Ou-yang, ZY Zhang, CW Liu, HZ Zeng, JA Huang, ZH Liu

Food & Function (Royal Society of Chemistry) China, 21 February 2023

Endocrinology

SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway

W Zhang, X Li, M Jiang, C Ji, G Chen, Q Zhang, P Liu, R Zhang, X Ren, W Yu, J Yu

Journal of Leukocyte Biology (Oxford Academic) China, 20 February 2023

Oncology

Key words: breast cancer, early-stage myeloid-derived suppressor cells, Wnt/mTOR pathway, autophagy [more]

Intestinal Farnesoid X Receptor Modulates Duodenal Surface Area but Does Not Control Glucose Absorption in Mice

J Yang, TH van Dijk, M Koehorst, R Havinga, JF de Boer, F Kuipers

International Journal of Molecular Sciences (MDPI) The Netherlands, 18 February 2023

Enterology

Key words: glucose absorption, intestinal FXR, duodenum, GS3972 [more]

MRI histogram analysis of tumor-infiltrating CD8+ T cell levels in patients with glioblastoma

C Xue, Q Zhou, P Zhang, B Zhang, Q Sun, S Li, J Deng, X Liu, J Zhou

NeuroImage: Clinical (Elsevier) China, 18 February 2023

Oncology

Key words: Glioblastoma, Magnetic resonance imaging, Histogram analysis, CD8+ T cells, Tumor microenvironment [more]

Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease

S Yan, X Zheng, Y Lin, C Li, Z Liu, J Li, Z Tu, Y Zhao, C Huang, Y Chen, J Li, X Song, B Han, W Wang, W Liang, L Lai, XJ Li, S Li

Nature Biomedical Engineering (Nature) China, 16 February 2023

Neuroscience

Key words: Huntington's disease, Preclinical research [more]

Bavachinin Protects the Liver in NAFLD by Promoting Regeneration via Targeting PCNA

X Dong, S Lu, Y Tian, H Ma, Y Wang, X Zhang, G Sun, Y Luo, X Sun

Journal of Advanced Research (Elsevier) China, 16 February 2023

Hepathology

Key words: Bavachinin, CC-ABPP, NAFLD, Liver regeneration, PCNA [more]

Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-specific Pathways

Y Li, P Liu, Y Zhou, H Maekawa, JB Silva, MJ Ansari, K Boubes, Y Alia, DK Deb, BR Thomson, J Jin, SE Quaggin

Journal of The American Society of Nephrology (Wolters Kluwer) USA, 14 February 2023

Nephrology

[more]

Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer

M Zagorulya, L Yim, DM Morgan, A Edwards, E Torres-Mejia, N Momin, CV McCreery, IL Zamora, BL Horton, JG Fox, KD Wittrup, JC Love, S Spranger

Immunity (Cell Press) USA, 14 February 2023

Immunology, Oncology

Key words: regulatory T cells, cross-presenting dendritic cells, cytotoxic T cells, T cell dysfunction, T cell priming, anti-tumor immunity, non-small cell lung cancer, interferon-gamma, Th1-like effector regulatory T cells, tissue-specific immunity [more]

Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation

T Krausgruber, A Redl, D Barreca, K Doberer, D Romanovskaia, L Dobnikar, M Guarini, L Unterluggauer, L Kleissl, D Atzmuller, C Mayerhofer, A Kopf, S Saluzzo, CX Lim, P Rexie, T Weichhart, C Bock, G Stary

Immunity (Cell Press) Austria, 14 February 2023

Immunology

[more]

CD39-Expressing CD8+ T Cells as a New Molecular Marker for Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma

M Liu, Y Zhao, Z Xiao, R Zhou, X Chen, S Cui, S Cao, X Huang, T Chen, X Huo, G Zhang, Z Tian, N Wang

Cancers (MDPI) China, 13 February 2023

Oncology

Key words: esophageal squamous cell carcinoma, CD39+CD8+ T cells, diagnosis, prognosis, nomogram, tumor microenvironment [more]

Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis

T Qiao, W Yang, X He, P Song, X Chen, R Liu, J Xiao, X Yang, M Li, Y Gao, G Chen, Y Lu, J Zhang, J Leng, H Ren

Cell Death & Disease (Nature) China, 13 February 2023

Oncology

Key words: Cancer microenvironment, Kupffer cells, Metastasis, Tumour angiogenesis [more]

Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1

X Liu, Y Jiang, H Zhou, X Zhao, M Li, Z Bao, Z Wang, C Zhang, Z Xie, J Zhao, Z Dong, K Liu, Z Guo

Cell Death & Disease (Nature) China, 13 February 2023

Oncology

Key words: Cancer prevention, Proteomics, Target identification [more]

Prevalence of tumour-infiltrating CD103+ cells identifies therapeutic-sensitive prostate cancer with poor clinical outcome

Q Zhou, Y Ou, X Dai, X Chen, S Wu, W Chen, M Hu, C Yang, L Zhang, H Jiang

British Journal of Cancer (Nature) China, 09 February 2023

Oncology

Key words: Cancer microenvironment, Immune evasion, Prognostic markers [more]

Skin infiltrate composition as a telling measure of responses to checkpoint inhibitors.

C Kosche, D Jaishankar, C Cosgrove, P Ramesh, S Hong, L Li, RS Shivde, D Bhuva, BE Perez White, SS Munir, H Zhang, KQ Lu, JN Choi, IC Le Poole

JID Innovations (Elsevier) USA, 09 February 2023

Oncology

[more]

Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet‐Induced Adiposity

Y Sun, J Zhang, J Hong, Z Zhang, P Lu, A Gao, M Ni, Z Zhang, H Yang, J Shen, J Liu, W Xue, Q Lv, Y Bi, YA Zeng, W Gu, G Ning, W Wang, R Liu, J Wang

Advanced Science (Wiley) China, 08 February 2023

Endocrinology

Key words: obesity, pathogenic gene, RSPO1, thermogenesis, whole-exome sequenc-ing, Wnt signaling [more]

Artificial Base-Directed In Vivo Assembly of an Albumin–siRNA Complex for Tumor-Targeting Delivery

Y Sun, D Yu, X Geng, D Ding, Y Yang, Z Liu, Z Xiao, R Wang, W Tan

ACS Applied Materials & Interfaces (ACS Publications) China, 07 February 2023

Oncology, Pharmacology

Key words: artificial base, siRNA, albumin, targeted delivery, long circulation, tumor accumulation [more]

Empagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis

CC Chung, YK Lin, YC Chen, YH Kao, YH Yeh, NN Trang, YJ Chen

Cardiovascular Diabetology (Springer) Taiwan, Vietnam, 06 February 2023

Cardiology

Key words: Fibroblasts, Fibrosis, Empagliflozin, Sodium-glucose co-transporter 2, Calcium, Sodium-Hydrogen exchanger [more]

Synthesis and Anti-Melanoma Activity of L-Cysteine-Coated Iron Oxide Nanoparticles Loaded with Doxorubicin

LI Toderascu, LE Sima, S Orobeti, PE Florian, M Icriverzi, VA Maraloiu, C Comanescu, N Iacob, V Kuncser, I Antohe, G Popescu-Pelin, G Stanciu, P Ionita, CN Mihailescu, G Socol

Nanomaterials (MDPI) Romania, 04 February 2023

Nanomedicine

Key words: magnetic nanoparticles, melanoma, L-Cys, Dox, chemotherapeutic [more]

The Role of Green Tea Catechin Epigallocatechin Gallate (EGCG) and Mammalian Target of Rapamycin (mTOR) Inhibitor PP242 (Torkinib) in the Treatment of Spinal Cord Injury

L Machova Urdzikova, V Cimermanova, K Karova, J Dominguez, K Stepankova, M Petrovicova, K Havelikova, CD Ghandi, M Jhanwar-Uniyal, P Jendelova

Antioxidants (MDPI) Czech Republic, USA, 03 February 2023

Neuroscience

Key words: spinal cord injury, mTOR pathway, EGCG, PP 242, inflammatory response, neuroregeneration, astrogliosis, axonal growth [more]

Amentoflavone induces caspase‐dependent/− independent apoptosis and dysregulates cyclin‐dependent kinase‐mediated cell cycle in colorectal cancer in vitro and in vivo

CH Lin, KH Lin, HJ Ku, KC Lee, SS Lin, FT Hsu

Environmental Toxicology (Wiley) Taiwan, 02 February 2023

Oncology

[more]

Mapping thalamic innervation to individual L2/3 pyramidal neurons and modeling their 'readout'of visual input

A Balcioglu, R Gillani, M Doron, K Burnell, T Ku, A Erisir, K Chung, I Segev, E Nedivi

Nature Neuroscience (Nature) USA, South Korea, Israel, 02 February 2023

Neuroscience

Key words: Sensory processing, Striate cortex [more]

Apolipoprotein E negatively regulates allergic airway inflammation and remodeling in mice with OVA-induced chronic asthma

Y Shen, L Li, W Chen, Q Li, Y Xu, F He, C Wang, Z Tian, Y Chen, Y Yang

International Immunology (Elsevier) China, 01 February 2023

Allergy Research

Key words: ApoE, Airway remodeling, Chronic airway inflammation, Th2 responses [more]

Overexpression of Both Human Sodium Iodide Symporter (NIS) and BRG1-Bromodomain Synergistically Enhances Radioiodine Sensitivity by Stabilizing p53 through NPM1 Expression

J Na, CH Lee, JK Chung, H Youn

International Journal of Molecular Sciences (MDPI) South Korea, 01 February 2023

Oncology

Key words: sodium iodide symporter, radioiodine therapy, iodine-131, brahma-related gene 1 bromodomain, radiosensitization, thyroid cancer [more]

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models

M Datta, S Chatterjee, EM Perez, S Gritsch, S Roberge, M Duquette, IX Chen, K Naxerova, A S Kumar, M Ghosh, KE Emblem, MR Ng, WW Ho, P Kumar, S Krishnan, X Dong, MC Speranza, MR Neagu, JB Iorgulescu, RY Huang, G Youssef, DA Reardon, AH Sharpe, GJ Freeman, ML Suvà, L Xu, RK Jain

PNAS (Proceedings of the National Academy of Sciences of the United States of America) USA, Poland, Norway, 01 February 2023

Immunology, Oncology

Key words: immune checkpoint blockers, glioblastoma, immune-related adverse events, tumor microenvironment , biomarkers [more]

miR-432 exerts a protective effect against myocardial ischemia/reperfusion injury by activating the β-catenin/HIF-1α pathway and augmenting NRF2-mediated anti-oxidative stress

RY Su, WY Tai, HS Yin, XY Geng

American Journal of Translational Research (e-Century Publishing Corporation) China, 30 January 2023

Cardiology

Key words: microRNA, myocardial ischemia/reperfusion injury, apoptosis, oxidative stress [more]

Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression

C Liu, M Zhang, X Yan, Y Ni, Y Gong, C Wang, X Zhang, L Wan, H Yang, C Ge, Y Li, W Zou, R Huang, X Li, B Sun, B Liu, J Yue, J Yu

Science Advances (Science) China, 27 January 2023

Oncology

[more]

Development and Characterization of a Highly Selective Turn-On Fluorescent Ligand for β3-Adrenergic Receptor

W Li, Z Ma, L Du, M Li

Analytical Chemistry (ACS Publications) China, 26 January 2023

Biological Methods

[more]

Transcriptional Regulation of Math1 by Aryl Hydrocarbon Receptor: Effect on Math1+ Progenitor Cells in Mouse Small Intestine

Y Yagishita, T Joshi, TW Kensler, N Wakabayashi

Molecular and Cellular Biology (Taylor & Francis) USA, 26 January 2023

Gastroenterology

Key words: AhR, Math1, intestinal organoids, Math1+ progenitor cells, goblet cells

Lingguizhugan decoction improves non-alcoholic steatohepatitis partially by modulating gut microbiota and correlated metabolites

M Zhu, X Wang, K Wang, Z Zhao, Y Dang, G Ji, F Li, W Zhou

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) China, 26 January 2023

Hepathology

Key words: Lingguizhugan decoction, NASH, MCD diet, gut microbiota, metabolomics [more]

New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma

IV Militaru, AA Rus, CVA Munteanu, G Manica, SM Petrescu

Frontiers in Oncology (Frontiers Media S.A.) Romania, 26 January 2023

Oncology

Key words: melanoma biomarkers, amelanotic melanoma, mass spectrometry, proteomics, melanoma diagnostic, melanoma prognostic [more]

PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon

X Yang, T Yabe-Wada, J Han, F Saito, C Ogasawara, S Yamada, N Onai

International Immunology (Oxford Academic) Japan, China, 25 January 2023

Immunology

Key words: PCBP1, macrophage, CCL2, IBD, proinflammatory cytokine

Glycoside combinations of Buyang Huanwu decoction ameliorate atherosclerosis via STAT3, HIF-1, and VEGF

F Yan, H Ding, Z Sun, J Liu, J Li, D Zhou, W Zhang

Naunyn-Schmiedeberg's Archives of Pharmacology (Springer) China, 24 January 2023

Cardiology, Pharmacology

Key words: Network pharmacology, Buyang Huanwu decoction, Glycoside combination, Atherosclerosis, Angiogenesis [more]

Melatonin improves muscle injury and differentiation by increasing Pax7 expression

CM Su, CH Tsai, HT Chen, YS Wu, JW Chang, SF Yang, CH Tang

International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan, 22 January 2023

Pharmacology

Key words: melatonin, Pax7, muscle injury, differentiation, miR-3475-3p [more]

Modulatory Effects of Heat-Inactivated Streptococcus Thermophilus Strain 7 on the Inflammatory Response: A Study on an Animal Model with TLR3-Induced Intestinal Injury

GA Lee, YW Chang, WL Lin, YCSH Yang, WJ Chen, FH Huang, YR Liu

Microorganisms (MDPI) Taiwan, Malaysia, 20 January 2023

Microbiology, Immunology

Key words: Streptococcus thermophilus, microbiota, poly I:C, inflammation, IL-15 [more]

Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?

D Schmidbauer, S Fink, F Rousset, H Löwenheim, P Senn, R Glueckert

International Journal of Molecular Sciences (MDPI) Austria, Germany, Switzerland, 19 January 2023

Neuroscience

Key words: nerve regeneration, cochlear implant, spiral ganglion, neurotrophin treatment, electrical stimulation [more]

Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington's disease

A Matsushima, SS Pineda, JR Crittenden, H Lee, K Galani, J Mantero, G Tombaugh, M Kellis, M Heiman, AM Graybiel

Nature Communications (Nature) USA, 17 January 2023

Neuroscience

Key words: Huntington's disease, Molecular neuroscience, Transcriptomics [more]

Engineering orthotopic tumor spheroids with organ-specific vasculatures for local chemoembolization evaluation

Y Gao, J Xiao, Z Chen, Y Ma, X Liu, D Yang, H Liang Leo, H Yu, J Kong, Q Guo

Biomaterials Science (Royal Society of Chemistry) China, Singapore, 17 January 2023

Biological Methods

Prognostic role of the innate immune signature CD163 and “eat me” signal calreticulin in clear cell renal cell carcinoma

T Anno, N Tanaka, K Takamatsu, K Hakozaki, R Kufukihara, Y Baba, T Takeda, K Matsumoto, S Morita, T Kosaka, S Mikami, H Nishihara, R Mizuno, M Oya

Cancer Immunology, Immunotherpay (Springer) Japan, 17 January 2023

Oncology

Key words: Renal cell carcinoma, Kidney cancer, Innate immunity, CD163, Tumor-associated macrophage, Calreticulin, Eat me signal, Survival [more]

Environmental endocrine disruptor Bisphenol A induces metabolic derailment and obesity via upregulating IL-17A in adipocytes

X Hong, Y Zhou, Z Zhu, Y Li, Z Li, Y Zhang, XX Hu, F Zhu, Y Wang, M Fang, Y Huang, T Shen

Environment International (Elsevier) China, 16 January 2023

Endocrinology

Key words: Obesity, Bisphenol A, Inflammation, Insulin resistance, IL-17A [more]

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

D Savic, TB Steinbichler, J Ingruber, G Negro, B Aschenbrenner, H Riechelmann, U Ganswindt, S Skvortsov, J Dudas, II Skvortsova

Cells (MDPI) Austria, 16 January 2023

Oncology

Key words: HNSCC, erastin, xCT, ERK signaling [more]

Daurisoline suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting MEK1/2 kinase

D Wang, W Zhang, X Zhang, M Li, Q Wu, X Li, L Zhao, Q Yuan, Y Yu, J Lu, J Zhao, Z Dong, K Liu, Y Jiang

Molecular Carcinogenesis (Wiley) China, 16 January 2023

Oncology

[more]

Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia–reperfusion injury

T Mei, J Wu, K Wu, M Zhao, J Luo, X Liu, B Shang, W Xu, Z Yang, Y Lai, C Liu, H Gong, X Gao, Y Zhuo, M Lin, L Zhao

Annals of Translational Medicine (AME Publishing Company) China, 15 January 2023

Ophthalmology

Key words: Lipocalin-2 (LCN2), retinal ischemia-reperfusion injury (RIR injury), ferroptosis, retinal ganglion cell (RGC), visual impairment [more]

BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti‐PD‐1/PD‐L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity

Z Cai, J Chen, Z Yu, H Li, Z Liu, D Deng, J Liu, C Chen, C Zhang, Z Ou, M Chen, J Hu, X Zu

Advanced Science (Wiley) China, 15 January 2023

Oncology, Pharmacology

[more]

SN‐38, an active metabolite of irinotecan, enhances anti‐PD1 treatment efficacy in head and neck squamous cell carcinoma

YM Lee, YH Chen, DL Ou, CL Hsu, JH Liu, JY Ko, MCT Hu, CT Tan

The Journal of Pathology (Wiley) Taiwan, USA, 15 January 2023

Oncology

[more]

miR-432 exerts a protective effect against myocardial ischemia/reperfusion injury by activating the β-catenin/HIF-1α pathway and augmenting NRF2-mediated anti-oxidative stress

RY Su, WY Tai, HS Yin, XY Geng

American Journal of Translational Research (e-Century Publishing Corporation) China, 15 January 2023

Cardiology

Key words: apoptosis, microRNA, myocardial ischemia/reperfusion injury, oxidative stress [more]

Production and characterization of cell-penetrating recombinant botulinum neurotoxin type A

X Wei, J Hu, L Jiang, L Li, J Liu

STAR Protocols (Elsevier) China, 13 January 2023

Biological Methods

Key words: Cell culture, Protein Biochemistry, Protein Expression and Purification, Biotechnology and Bioengineering [more]

Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice

Q Ma, D Su, J Huo, G Yin, D Dong, K Duan, H Cheng, H Xu, J Ma, D Liu, B Mou, J Peng, L Cheng

Neuroscience Bulletin (Springer) China, 13 January 2023

Neuroscience

Key words: Microglia, Mechanical allodynia, Laterality, Spinal dorsal horn, Aβ, Dynamic allodynia, Punctate allodynia [more]

Theabrownin inhibits obesity and non-alcoholic fatty liver disease in mice via serotonin-related signaling pathways and gut-liver axis

HY Li, SY Huang, DD Zhou, RG Xiong, M Luo, A Saimaiti, MK Han, RY Gan, HL Zhu, HB Li

Journal of Advanced Research (Elsevier) China, 11 January 2023

Hepathology

Key words: non-alcoholic fatty liver disease, anti-obesity, theabrownin, serotonin, gut microbiota [more]

The imbalance of NKG2A and NKG2D expression is involved in NK cell immunosuppression and tumor progression of HBV‐HCC patients

L Yu, L Sun, X Liu, X Wang, H Yan, Q Pu, Y Xie, Y Jiang, J Du, Z Yang

Hepatology Research (Wiley) China, 11 January 2023

Oncology

Key words: NK cell, NKG2A, NKG2D, hepatitis B virus-related hepatocellular carcinoma, immunosuppression [more]

Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy

R Chi, C Chai, G Liu, H Cao, B Yang

Human Cell (Springer) China, 10 January 2023

Cardiology

Key words: OSAS, CIH, Autophagy, BNIP3, Apoptosis, Cardiac hypertrophy [more]

Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

D Liu, C Liang, B Huang, X Zhuang, W Cui, L Yang, Y Yang, Y Zhang, X Fu, X Zhang, L Du, W Gu, X Wang, C Yin, R Chai, B Chu

Advanced Science (Wiley) China, USA, 10 January 2023

Oncology

Key words: 3-HA, 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), 5-HT, ferroptosis, kynureninase (KYNU, monoamine oxidase A (MAOA), tryptophan [more]

Immune dysregulation in immunoglobulin G4–related disease

T Maehara, R Koga, S Nakamura

Japanese Dental Science Review (Elsevier) Japan, 09 January 2023

Immunology

Key words: Autoimmune, Anti-inflammatory, Single-cell RNA sequencing, IgG4-related disease, Cytotoxic T cells, Salivary gland

Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance

F Du, G Yin, L Han, X Liu, D Dong, K Duan, J Huo, Y Sun, L Cheng

Neuroscience Bulletin (Springer) China, 09 January 2023

Neuroscience

Key words: μ-opioid receptor, Morphine, Mechanical allodynia, Punctate allodynia, Dynamic allodynia, OIH, Tolerance, Aβ-fiber [more]

Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive 18F-FDG PET/CT and Serum 1H-NMR Analysis: An Orthotopic Murine Model Study

YH Chung, TH Hung, CF Yu, CK Tsai, CC Weng, F Jhang, FH Chen, G Lin

Metabolites (MDPI) Taiwan, 09 January 2023

Oncology

Key words: lung cancer, 18F-FDG, 1H-NMR, animal study, metastasis [more]

Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis

BY Ahn, Y Jeong, S Kim, Y Zhang, SW Kim, YE Leem, JS Kang

Experimental & Molecular Medicine (Nature) South Korea, 06 January 2023

Cell Biology

Key words: Calcification, Stress signalling [more]

Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts

YC Huang, MF Hou, YM Tsai, YC Pan, PH Tsai, YS Lin, CY Chang, EM Tsai, YL Hsu

Cellular Oncology (Springer) Taiwan, 06 January 2023

Oncology

Key words: Acetyl-CoA carboxylase α, Breast cancer, Metabolism reprogramming, Pre-metastatic niche, Senescence [more]

Role of iodine density value on dual-energy CT for detection of high tumor cell proportion region in lung cancer during CT-guided transthoracic biopsy

Y Ma, S Li, G Huang, X Huang, Q Zhou, W Wang, J Wang, F Zhao, Z Li, X Chen, B Zhu, J Zhou

European Journal of Radiology (Elsevier) China, 06 January 2023

Oncology, Radiotherapy

Key words: Dual-layer spectral detector computed tomography, Iodine density, Transthoracic lung biopsy, High tumor cell proportion region [more]

PLVAP as an Early Marker of Glomerular Endothelial Damage in Mice with Diabetic Kidney Disease

EE Wolf, A Steglich, F Kessel, H Kröger, J Sradnick, S Reichelt-Wurm, K Eidenschink, MC Banas, E Wolf, R Wanke, F Gembardt, VT Todorov

International Journal of Molecular Sciences (MDPI) Germany, 06 January 2023

Nephrology

Key words: diabetic kidney disease, endothelial damage, PLVAP, diabetic models, glomerular hypertrophy [more]

Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity

Z Fu, S Chen, Y Zhu, D Zhang, P Xie, Q Jiao, J Chi, S Xu, Y Xue, X Lu, X Song, M Christofanilli, WJ Gradishar, K Kalinsky, Y Yin, B Zhang, Y Wan

Science Advances (Science) USA, China, 06 January 2023

Oncology

[more]

The transcription factor Eomes promotes expression of inhibitory receptors on hepatic CD8+ T cells during HBV persistence

L Yu, Y Guan, L Li, N Lu, C Zhang

The FEBS Journal (Wiley) China, 05 January 2023

Virology, Immunology

Key words: CD8+ T cell exhaustion, chronic HBV persistence, Eomes, inhibitory receptor, transcription factor [more]

Comparing the Therapeutic Mechanism and Immune Response of Human and Mouse Mesenchymal Stem Cells in Immunocompetent Mice With Acute Liver Failure

CH Wang, CY Chen, KH Wang, AP Kao, YJ Chen, PH Lin, M Chen, TY Wu, JJ Cheng, KD Lee, KH Chuang

Stem Cells Translational Medicine (Oxford Academic) Taiwan, 04 January 2023

Immunology, Hepathology

Key words: mesenchymal stem cells, immunomodulatory, IL-6, F4/80, liver regeneration, liver fibrosis [more]

Limonin counteracts obesity by activating thermogenesis in brown and white adipose tissues

M Yan, S Jin, Z Wang, T Xia, Y Liu, Q Chang

Journal of Functional Foods (Elsevier) China, 02 January 2023

Endocrinology

Key words: Limonin, Obesity, Brown adipose tissue, White adipose tissues, Thermogenesis [more]

Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma

JL Sieow, HL Penny, SY Gun, LQ Tan, K Duan, JPS Yeong, A Pang, D Lim, HC Toh, TKH Lim, E Engleman, O Rotzschke, LG Ng, J Chen, SM Tan, SC Wong

International Journal of Molecular Sciences (MDPI) Singapore, USA, 01 January 2023

Oncology

Key words: neutrophils, pancreatic cancer, hypoxia-inducible factor 1-alpha [more]

The TgF344-AD Rat: Behavioral and Proteomic Changes Associated with Aging and Protein Expression in a Transgenic Rat Model of Alzheimer's Disease

B Bac, C Hicheri, C Weiss, A Buell, N Vilcek, C Spaeni, C Geula, JN Savas, JF Disterhoft

Neurobiology of Aging (Elsevier) USA, 30 December 2022

Neuroscience

Key words: watermaze, 6E10, pTau, neuroinflammation, TREM2, Learning Index, proteomics [more]

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Y Zhou, X He, Y Jiang, Z Wang, Y Yu, W Wu, C Zhang, J Li, Y Huo, X Chen, Z Liu, J Zhao, K Liu, Z Dong

Frontiers of Medicine (Springer) China, 29 December 2022

Oncology

Key words: benzydamine, cyclin-dependent kinase 2, patient-derived xenograft, esophageal squamous cell carcinoma [more]

The effect of isovitexin on lipopolysaccharide-induced renal injury and inflammation by induction of protective autophagy

CY Tseng, PR Yu, CC Hsu, HH Lin, JH Chen

Food and Chemical Toxicology (Elsevier) Taiwan, 23 December 2022

Nephrology

Key words: Kidney injury, Isovitexin, Lipopolysaccharide, Inflammation, Autophagy [more]

Myofibroblast stroma differentiation in infiltrative basal cell carcinoma is accompanied by regulatory T‐cells

JM Ressler, N Zila, A Korosec, J Yu, R Silmbrod, V Bachmayr, J Tittes, J Strobl, BM Lichtenberger, C Hoeller, P Petzelbauer

Journal of Cutaneous Pathology (Wiley) Austria, 23 December 2022

Oncology

Key words: Basal cell carcinoma, infiltrative BCC, regulatory T-cells, TGF-β, alpha smooth muscle actin [more]

Mitigation of Cellular and Bacterial Adhesion on Laser Modified Poly (2-Methacryloyloxyethyl Phosphorylcholine)/Polydimethylsiloxane Surface

S Nistorescu, M Icriverzi, P Florian, A Bonciu, V Marascu, N Dumitrescu, G Gradisteanu Pircalabioru, L Rusen, A Mocanu, A Roseanu, A Cimpean, F Grama 6, V Dinca, DA Cristian

Nanomaterials (MDPI) Romania, 23 December 2022

Tissue Engineering

Key words: MAPLE, zwitterionic coating, cellular response [more]

Biomimetic Prussian blue nanozymes with enhanced bone marrow-targeting for treatment of radiation-induced hematopoietic injury

B Zhang, G Chen, X Wu, Y Li, Y Xiao, J Li, L He, Y Li, S Wang, J Zhao, C Liu, H Zhou, Y Li, X Pei

Biomaterials (Elsevier) China, 21 December 2022

Nanomedicine

Key words: Prussian blue nanozymes, Mesenchymal stem cell membrane, Reactive oxygen species, Radiation-induced hematopoietic injury, Targeting therapy [more]

Avicularin Alleviates Osteoporosis in Ovariectomized Mice by Inhibiting Osteoclastogenesis through NF-κB Pathway Inhibition

Q Zhuang, S Chen, W Zhang, M Gu, L Xiao, Y Li, Y Yang, C Feng, H Li, D Geng, Z Wang

Journal of Agricultural and Food Chemistry (ACS Publications) China, 20 December 2022

Osteology

Key words: osteoclast avicularin bone loss NF-κB [more]

R158Q and G212S, novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome

Z Li, H Wu, S Wei, M Liu, Y Shi, M Li, N Wang, L Fang, B Xiang, L Gao, C XU, J Zhao

Frontiers of Medicine (Frontiers Media S.A.) China, 19 December 2022

Endocrinology

Key words: Gitelman syndrome, mouse model, compound heterozygous, hypokalemia, Slc12a3 [more]

A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging

H Zhang, Y Guo, J Jiao, Y Qiu, Y Miao, Y He, Z Li, C Xa, L Li, J Cai, K Xu, X Liu, C Zhang, BH Bay, S Song, Y Yang, M Peng, Y Wang, H Fan

Nature Biomedical Engineering (Nature) China, 19 December 2022

Biological Methods

Key words: Biomedical engineering, Magnetic resonance imaging [more]

Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

PA Goldsteen, AM Sabogal Guaqueta, PPM Mulder, IST Bos, M Eggens, L Van der Koog, JT Soeiro, AJ Halayko, K Mathwig, LEM Kistemaker, EMJ Verpoorte, AM Dolga, R Gosens

Frontiers in Pharmacology (Frontiers Media S.A.) The Netherlands, 18 December 2022

Neuroscience

Key words: asthma, cholinergic, neuron, organ-on-chip, stem cell [more]

Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice

STJ Ang, EM Crombie, H Dong, KT Tan, A Hernando, D Yu, S Adamson, S Kim, DJ Withers, H Huang, SY Tsai

Nature Communications (Nature) Singapore, USA, UK, 17 December 2022

Aging

Key words: Ageing, Muscle stem cells, Skeletal muscle [more]

Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10

J Yang, C Hou, H Wang, EA Perez, HC Do-Umehara, H Dong, V Arunagiri, F Tong, M Van Scoyk, M Cho, X Liu, X Ge, RA Winn, KM Ridge, X Wang, NS Chandel, J Liu

Cancer Letters (Elsevier) USA, 17 December 2022

Oncology

Key words: KRAS, Non-small cell lung cancer, Pcdh10, Gene regulation, Miz1 [more]

FOXM1 increases hTERT protein stability and indicates poor prognosis in gastric cancer

Q Tang, C Liu, S Zhang, L He, Y Liu, J Wang, X Zhao, X Li

Neoplasia (Elsevier) China, 16 December 2022

Oncology

Key words: Gastric cancer, FOXM1, hTERT, ubiquitination, Wnt/β-catenin [more]

Distribution and Toxicity of Submicron Plastic Particles in Mice

TY Tsou, SH Lee, TH Kuo, CC Chien, HC Chen, TJ Cheng

Environmental Toxicology and Pharmacology (Elsevier) Taiwan, 15 December 2022

Toxicology

Key words: Submicron microplastics, Oral gavage, Number concentration, Flow cytometry, Oxidative stress, Inflammation [more]

Synergistic cytotoxicity of perifosine and ABT‐737 to colon cancer cells

B Adamová, K Říhová, J Pokludová, P Beneš, J Šmarda, J Navrátilová

Journal of Cellular and Molecular Medicine (Wiley) Czech Republic, 15 December 2022

Oncology

[more]

Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions

M Salzmann, H Platzer, M Mussbacher, M Derler, M Lenz, P Haider, M Brekalo, JB Kral-Pointner, S Kastl, WS Speidl, KT Preissner, U Schubert, M Bischoff, J Wojta, PJ Hohensinner

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Austria, Germany, 10 December 2022

Immunology, Microbiology

Key words: Atherosclerosis, ICAM-1, Extracellular adherence protein, Neutrophils, NET [more]

Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells

J Chen, J Liu, Z Chen, D Feng, C Zhu, J Fan, S Zhang, X Zhang, J Xu

Virologica Sinica (Elsevier) China, 10 December 2022

Virology

Key words: Myosin IIA (MYH9), Influenza A virus (IAV), vRNP activity, Virus-host interactions, Virus entry [more]

A Proof-of-Concept Preclinical Study Using a Novel Thermal Insulation Device in a Porcine Kidney Auto-Transplantation Model

L Ernst, Z Czigany, P Paschenda, M Schulz, L Breuer, J Kunczik, M Czapli, W Liu, D Jiang, U Klinge, S Djudjaj, P Boor, G Lurje, E Kobayashi, RH Tolba

International Journal of Molecular Sciences (MDPI) Germany, Japan, 09 December 2022

Transplantation Medicine

Key words: kidney transplantation, organ insulation, ischemic reperfusion injury [more]

The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer's disease mouse model

CF de Veij Mestdagh, F Koopmans, JC Breiter, JA Timmerman, PC Vogelaar, G Krenning, HD Mansvelder, AB Smit, RH Henning, RE van Kesteren

Alzheimer's Research & Therapy (Springer) The Netherlands, 09 December 2022

Neuroscience

Key words: Alzheimer's disease, APP/PS1 mice, Hibernation-derived compound, SUL-138, Chromanols, Long-term potentiation, Hippocampus-dependent contextual fear memory, Amyloid-beta plaques, Mass-spectrometry, Mitochondria, Fatty acid metabolism [more]

Angiotensin-converting enzyme 2 in human plasma and lung tissue

J Xie, QF Huang, Z Zhang, Y Dong, H Xu, Y Cao, X Wang, JG Wang

Blood Pressure (Taylor & Francis) China, 09 December 2022

Cardiology

Key words: ACE2, plasma, lung, tissue, hypertension

Fumarate hydratase inhibits non‑small cell lung cancer metastasis via inactivation of AMPK and upregulation of DAB2

A Vadhan, YF Yang, YM Wang, PY Chen, SC Tzou, KH Cheng, SCS Hu, TL Cheng, YY Wang, SSF Yuan

Oncology Letters (Spandidos Publications) Taiwan, 09 December 2022

Oncology

[more]

Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer

K Imamura, Y Tomita, R Sato, T Ikeda, S Iyama, T Jodai, M Takahashi, A Takaki, K Akaike, S Hamada, S Sakata, K Saruwatari, S Saeki, K Ikeda, M Suzuki, T Sakagami

International Journal of Molecular Sciences (MDPI) Japan, USA, 08 December 2022

Oncology

Key words: drebrins, lymphocytes, tumor-infiltrating, lung neoplasms, tumor microenvironment, prognosis [more]

Effects of a Phytogenic Supplement Containing Olive By-Product and Green Tea Extracts on Growth Performance, Lipid Metabolism, and Hepatic Antioxidant Capacity in Largemouth Bass (Micropterus salmoides) Fed a High Soybean Meal Diet

J Liu, M Xue, S Morais, M He, H Wang, J Wang, JJ Pastor, RA Gonçalves, X Liang

Antioxidants (MDPI) China, Spain, 07 December 2022

Zoology

Key words: largemouth bass, soybean meal, phytogenic feed additive, antioxidant capacity, lipid metabolism [more]

Hybrid Transcytosis Nanopomegranates for Sensitizing Breast Cancer Radiotherapy in Deep Tumor Tissue

L Wang, L Xiao, Z Zhao, K Zhong, W Zhu, H Liu, X Li

Nano Research (Scipen) China, 07 December 2022

Oncology

Key words: Breast cancer, transcytosis, hybrid nanopomegranate, hypoxia alleviation, radiosensitization [more]

HMGB1 Promotes In Vitro and In Vivo Skeletal Muscle Atrophy through an IL-18-Dependent Mechanism

TL Ho, CH Tang, SLY Chang, CH Tsai, HT Chen, CM Su

Cells (MDPI) Taiwan, 06 December 2022

Pharmacology

Key words: HMGB1, IL-18, inflammation, myogenesis, skeletal muscle atrophy [more]

Role of Artificial Intelligence in Cancer Diagnosis and Drug Development

S Srivastava, D Paliwal

Combinatorial Chemistry & High Throughput Screening (Ingenta conect) , 02 December 2022

Oncology

Key words: Cancer, artificial intelligence, computational approach, deep learning, drug development, machine learning

Sex-based difference in response to recombinant human bone morphogenetic protein-2 in a rat posterolateral fusion model

JP Foley, EJ Fred, S Minardi, JT Yamaguchi, AC Greene, AA Furman, JG Lyons, JT Paul, TS Nandurkar, KR Blank, RM Havey, M Muriuki, AG Patwardhan, WK Hsu, SR Stock, EL Hsu

Spine (Ingenta conect) USA, 01 December 2022

Key words: BMP, BMP-2, bone, healing, regeneration, rhBMP-2, sex, sex-dependent differences, spinal fusion, spine

Tactile cues are important to environmental novelty during repeated open field tests

W Chen, Z Wang, C Ma, X Ma, W Meng, F Yin, Y Yang

Behavioural Processes (Elsevier) China, 30 November 2022

Zoology

Key words: Anxiety, CA1, Environment, Open field test, Repeated testing, Tactile [more]

Xenobiotic-induced ribosomal stress compromises dysbiotic gut barrier aging: A one health perspective

J Sun, J Kim, H Jeong, D Kwon, Y Moon

Redox Biology (Elsevier) South Korea, 30 November 2022

Toxicology

Key words: Gut aging, Ribosomal stress, Deoxynivalenol, Gut barrier, Microbiota [more]

MiR-140 is involved in T-2 toxin-induced matrix degradation of articular cartilage

Y Shi, X Shao, M Sun, J Ma, B Li, N Zou, F Li

Toxicon (Elsevier) China, 30 November 2022

Toxicology

Key words: miR-140, T-2 toxin, KBD, Articular cartilage, Extracellular matrix [more]

Blockade of c-Met-Mediated Signaling Pathways by E7050 Suppresses Growth and Promotes Apoptosis in Multidrug-Resistant Human Uterine Sarcoma Cells

TT Huang, CM Chen, YW Lan, SS Lin, KB Choo, KY Chong

International Journal of Molecular Sciences (MDPI) Taiwan, USA, Malaysia, 28 November 2022

Pharmacology, Oncology

Key words: E7050, multidrug-resistant uterine sarcoma, apoptosis, cell cycle arrest, c-Met [more]

The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice

ZD Li, H Li, S Kang, YG Cui, H Zheng, P Wang, K Han, P Yu, YZ Chang

Cell Death & Disease (Nature) China, 28 November 2022

Neuroscience

Key words: Alzheimer's disease, Cognitive ageing [more]

Aspirin curcumin ester loaded biomimetic nanodrug improves cognitive deficits in a mouse model of Alzheimer's disease by regulating M1/M2 microglial polarization

Z Li, Z Song, C He, J Fan, W Yu, M Yang, P Li, R Luo, J Zhou, S Xu, B Liu, S Cheng

Materials Today Advances (Elsevier) China, 26 November 2022

Nanomedicine

Key words: Alzheimer's disease, Microglia, Neuroinflammation, Nanoparticle, APP/PS1 [more]

3, 3′-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy

H Tang, K Qin, A Wang, S Li, S Fang, W Gao, M Lu, W Huang, H Zhang, Z Yin

Frontiers in Pharmacology (Frontiers Media S.A.) China, 25 November 2022

Osteology

Key words: 3, 3′-diindolylmethane, osteoarthritis, apoptosis, autophagy, chondrocyte [more]

Co-assembled Nanocarriers of De Novo Thiol-Activated Hydrogen Sulfide Donors with an RGDFF Pentapeptide for Targeted Therapy of Non-Small-Cell Lung Cancer

H Chen, X Guan, Q Liu, L Yang, J Guo, F Gao, Y Qi, X Wu, F Zhang, X Tian

ACS Applied Materials & Interfaces (ACS Publications) China, 22 November 2022

Oncology, Nanomedicine

Key words: thiol-activated hydrogen sulfide donors, targeted pentapeptide, coassembled nanocarrier, non-small cell lung cancer, combined radiotherapy [more]

Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression

D Yang, H Liu, Y Cai, K Lu, X Zhong, S Xing, W Song, Y Zhang, L Ye, X Zhu, T Wang, P Zhang, ST Li, J Feng, W Jia, H Zhang, ST Li, J Feng, W Jia, H Zhang, P Gao

Cell Reports (Cell Press) China, 22 November 2022

Oncology

Key words: branch-chain amino acid, glutamine-depravation, O-GlcNAcylation, HCC progression [more]

Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling

HC Wang, LY Haung, CJ Wang, YJ Chao, YC Hou, CJ Yen, YS Shan

Journal of Biomedical Science (BMC) Taiwan, 21 November 2022

Oncology

Key words: Hepatocellular carcinoma, Sorafenib resistance, Tumor-associated macrophage, CXCR2, CXCL1, CXCL2 [more]

Overcoming oxygen heterogeneity of tumor microenvironments to boost cancer immunotherapy by oxygen-switchable ROS/RNS nanogenerators

W Jiang, Z Shen, Z Guo, Q Wang, Q Li, J Hu, Y Wang

Nano Today (Elsevier) China, 21 November 2022

Oncology

Key words: Oxygen-switchable ROS/RNS-releasing polymers, Oxygen heterogeneity, Immunogenic cell death, Cancer immunotherapy [more]