Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3186 papers published)

01
Caspase Inhibition Restores Collagen I α1 and Fibronectin Release in Cigarette Smoke Extract-Exposed Human Lung Fibroblasts

AL Mensa, M Buscetta, RR Woldhuis, M Cimino, MR Giuffrè, M Cristaldi, P Dino, L Fiore, A Fucarino, GL Iacono, A Bertani, CA Brandsma, F Bucchieri, C Cipollina

American Journal of Physiology Lung Cellular and Molecular Physiology (American Physiological Society) Italy, The Netherlands, 06 February 2025

Pulmonology

Key words: caspase; cigarette smoke extract; extracellular matrix; gasdermin E; human lung fibroblasts

Organism: Human

Tissue: Lung

Pathological State: Smoking

02
Morphometry of the Scapular Notch and Its Clinical Implication in Suprascapular Nerve Entrapment

J Duque-Colorado, OA Alzate-Mejia, M del Sol

Diagnostics (MDPI) Chile, Colombia, 02 February 2025

Osteology

Key words: advanced anatomy; morphometry; scapula; scapular notch; neuropathy; suprascapular nerve

Organism: Human

Tissue: Nerve

Pathological State: Entrapment Neuropathy

03
Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

L Ye, S Shen, Q Mao, H Lu, H Liu, P Zhang, Z Jiang, W Ma, Y Sun, Y Chu, Z Zhou, R Liu, J Li, ST Li, P Gao, H Zhang

Cell Reports (Cell) China, 31 January 2025

Oncology

Key words: hepatocellular carcinoma, post-translational modification, histone methylation

Organism: Human

Tissue: Liver

Pathological State: Cancer

04
VPS18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis–infected macrophages

C Jani, N Jain, AK Marsh, P Uchil, T Doan, M Hudspith, OT Glover, ZR Baskir, J Boucau, DE Root, NN van der Wel, JG Doench, AK Barczak

Science Advances (Science) USA, The Netherlands, 31 January 2025

Bacteriology

Organism: Human

Pathological State: Bacterial Infection

Cell Line: THP-1

05
Infiltration and subtype analysis of CD3+ CD20+ T cells in lung cancer

L Luo, J Ji, J Dong, M He, W Jiang, Y Liu, W Wang

BMC cancer (Springer) China, 30 January 2025

Oncology

Key words: Lung cancer, Tertiary lymphoid structures, CD3+CD20+T cell, Double negative T cell

Organism: Human

Tissue: Lung

Pathological State: Cancer

06
Alda‑1 restores ALDH2‑mediated alcohol metabolism to inhibit the NF‑κB/VEGFC axis in head and neck cancer

YH Lin, YC Lee, JB Liao, PL Yu, CY Chou, YF Yang

International Journal of Molecular Medicine (Spandidos Publications) Taiwan, 30 January 2025

Oncology

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

07
Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma

Y Cheng, X Chen, L Feng, Z Yang, L Xiao, B Xiang, X Wang, D Liu, P Lin, J Shi, G Song, W Qian, B Zhang, Y Xu, Z Gao, L Chen, Y Wu, J Ma, Y Lin, H Zhao, L Peng, X Mao, Y Liu, H Hou, M Yang, Y Ji, X Wang, J Zhou, X Xu, X Liu, W Wei, X Zhang, Q Gao, H Zhou, Y Sun, K Wu, J Fan

Cell Discovery (Nature) China, 28 January 2025

Oncology

Key words: Cancer microenvironment, Tumour immunology

Organism: Human

Tissue: Liver

Pathological State: Cancer

08
RNA-seq reveals Lysyl oxidase as a potential biomarker of glomerular function in diabetic nephropathy in rats

J Liu, S Bai, C Wu, C Tian, Q Fu, X Gao, B Zhang, X La

Gene (Elsevier) China, 27 January 2025

Nephrology

Key words: Diabetic nephropathy, Bioinformatic analysis, Lysyl oxidase, RNA-seq

Organism: Rat

Tissue: Kidney

Pathological State: Diabetes

09
Effect of in vivo reprogramming of astrocytes combined with exercise training on neurorepair in rats with spinal cord injury

Z Talifu, X Xu, H Du, Z Li, X Wang, C Zhang, Y Pan, H Ke, W Liu, F Gao, D Yang, Y Jing, Y Yu, L Du, J Li

Animal Models and Exerimental Medicine (Wiley Online Library) China, 23 January 2025

Neuroscience

Key words: astrocyte, exercise training, functional recovery, reprogramming, spinal cord injury

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

10
GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury

X Zhang, X Liu, Q Li, C Li, X Li, J Qian, J Li, X Li

PLOS One (PLOS One) China, 22 January 2025

Neuroscience

Key words: Soleus muscles, Spinal cod injury, Skeletal muscles, Spinal cord, Body weight, Exercise therapy, Muscle fibres, Muscle proteins

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

11
SUMO-Specific Peptidase 5 Promotes Oesophageal Squamous Cell Carcinoma Growth through the NF-κB-SLC1A3 Axis

C Du, Y Hu, X Yang, Z Zhang, J Gu, T Zhang, R Wang, S Zhang, L Tan, G Yu

Frontiers in Bioscience … (IMR Press) China, 22 January 2025

Oncology

Key words: SENP5, oesophageal squamous cell carcinoma, SLC1A3, NF-κB

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

12
HVEM as a Tumor-Intrinsic Regulator in Non-Small Cell Lung Cancer: Suppression of Metastasis via Glycolysis Inhibition and Modulation of Macrophage Polarization

Y Yao, B Li, C Chen, J Wang, F Yao, Z Li

Pharmacological Research (Elsevier) China, 18 January 2025

Oncology

Key words: NSCLC, HVEM, MPRIP, Glycolysis pathway, Macrophages, Tumor metastasis

Organism: Human

Tissue: Lung

Pathological State: Cancer

13
Understanding phage BX-1 resistance in Vibrio alginolyticus AP-1 and the role of quorum-sensing regulation

X Li, X Liu, T Ma, H Su, B Sui, L Wang, B Murtaza, Y Xu, N Li, D Tan

Microbiology Spectrum (ASM Journals) China, 14 January 2025

Bacteriology

Organism: Bacteria

Pathological State: Viral infection

Cell Line: AP-1, ΔbcsE AP-1, Δbcs AP-1

14
Exploring the molecular mechanisms of tirzepatide in alleviating metabolic dysfunction-associated fatty liver in mice through integration of metabolomics, lipidomics, and proteomics

J Liang, H Liu, G Lv, X Chen, Z Yang, K Hu, H Sun

Lipids in Health and Disease (Springer) China, 10 January 2025

Hepathology

Key words: Metabolic dysfunction-associated fatty liver disease, Tirzepatide, Metabolomics, Lipidomics, Proteomics

Organism: Mouse

Tissue: Liver

Pathological State: Fatty Liver Disease

15
Serum Exosomes miR-122-5P Induces Hepatic and Renal Injury in Septic Rats by Regulating TAK1/SIRT1 Pathway

J Wang, Y Jiang, Y Yuan, X Ma, T Li, YT Lv, J Zhang, L Chen, J Zhou, Y Meng, B Zhang

Infection and Drug Resistance (Taylor & Francis) China, 10 January 2025

Nephrology,Hepathology

Key words: sepsis, exosomem, iR-122-5p, NF-κB signaling pathway, sepsis-related liver and kidney injury

Organism: Rat

Tissue: Liver, Kidney

Pathological State: Sepsis

16
SRC enhanced cisplatin resistance in bladder cancer by reprogramming glycolysis and pentose phosphate pathway

Y Gong, D Gao, Y Shi, G Fan, X Yu, E Yang, H Cheng, J Tian, H Ding, S Liu, S Fu, Y Tao, Y Shui, L Cheng, L Li, Z Wang

Communications Biology (Nature) China, USA, 10 January 2025

Oncology

Key words: Bladder cancer, Cancer metabolism, Cancer therapeutic resistance, Glycobiology

Organism: Human

Tissue: Bladder

Pathological State: Cancer

17
A novel nanocarrier based on natural polyphenols enhancing gemcitabine sensitization ability for improved pancreatic cancer therapy efficiency

Y Dong, J Li, Y Dai, X Zhang, X Jiang, T Wang, B Zhao, W Liu, H Sun, P Du, L Qin, Z Jiao

Materials Today Bio (Elsevier) China, 08 January 2025

Oncology

Key words: Nanocarrier, 1,2,3,4,6-Pentagalloyl glucose, Gemcitabine, Sensitizing chemotherapy, Pancreatic cancer

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

18
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring

X Cheng, Y Xue, H Wang, Z Ma, N Hu, C Zhang, Y Gao, R Fan, L Hu, J Li, D Zhang, J Huang, S Fang, R Xiao, Y He, T Luo, L Zheng

Ecotoxicology and Enviormental Safety (Elsevier) China, 03 January 2025

Reproductive Medicine

Key words: Polystyrene nanoplastics, Primordial follicles, Maternal exposure, Reproductive damage, Progeny

Organism: Mouse

Tissue: Ovaries

Pathological State: Nanoplastic

19
Lung cancer–intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg cell–dependent CD8+ T-cell exclusion

E Torres-Mejia, S Weng, CA Whittaker, KB Nguyen, E Duong, L Yim, S Spranger

Cancer Immunology Research (AACR) USA, 02 January 2025

Oncology

Key words: Tumor microenvironment, T cell exclusion, tumor vasculature, checkpoint blockade therapy, non-small cell lung cancer, tumor-intrinsic SOX2 signaling pathway, regulatory T cells

Organism: Human

Tissue: Lung

Pathological State: Cancer

20
C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment

J Zhu, X Zhang, L Li, H Yang, H Liu, D Wu, Z Liu, B Liu, T Shen

Ecotoxicology and Enviormental Safety (Elsevier) China, 02 January 2025

Pulmonology

Organism: Mouse

Tissue: Lung

Pathological State: Fibrosis

21
FoxC1 activates Notch3 signaling to promote the inflammatory phenotype of keloid fibroblasts and aggravates keloid

Y Wang, Z Xia, W Wang, J Zhang, C Hu, F Wang, F Zhu, LS Fang, Jwang, X Li

Experimental Cell Research (Elsevier) China, 01 January 2025

Dermatology

Key words: Keloid, FoxC1, Notch3, Fibroblasts

Organism: Mouse, Human

Tissue: Skin

Pathological State: Keloid

22
Insights in glial cell pathology and multiple sclerosis: from an-omics and hiPSC perspective

M Wijering

(University of Groningen) The Netherlands, 01 January 2025

Neuroscience

Organism: Human

Tissue: Brain

Pathological State: Multiple Sclerosis

23
Long Afterglow Hybrid Nanoplatform for Integrated NIR-Ⅱ Imaging Diagnosis and Triple-synergistic Treatment of Choroidal Melanoma

L Yang, Y Wang, Y Guo, K Ge, P Wu, Y Du, Y Wang. Y Tang, W Zhang, W Liu

Talanta (Elsevier) China, 30 December 2024

Oncology

Key words: Long afterglow material, NIR-II imaging, Photothermal and photodynamic therapy, Sustained-release chemotherapy drugs, Choroidal melanoma

Organism: Mouse

Tissue: Eye

Pathological State: Cancer

24
Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNVIP neurons

Y Zhang, W Wang, J Li, D Zhao, Y Shu, X Jia, Y Wang, X Cheng, L Wang, J Cheng

Communications Biology (Nature) China, 28 December 2024

Neuroscience

Key words: Circadian rhythms and sleep, Molecular medicine

Organism: Mouse

Tissue: Brain

Pathological State: Chemical Exposure

25
Association of PD-1 + Treg/PD-1 + CD8 ratio and tertiary lymphoid structures with prognosis and response in advanced gastric cancer patients receiving preoperative treatment

X Liu, D Xu, C Zhou, Y Zhong, H Geng, C Huang, Y Shen, X Xia, C Wang, C Zhu, H Cao

Journal of Translational Medicine (BMC) China, 27 December 2024

Oncology

Key words: Gastric cancer (GC), PD-1 + Treg/PD-1 + CD8 ratio, Tertiary lymphoid structure (TLS), Neoadjuvant therapy, Conversion therapy

Organism: Human

Tissue: Stomach

Pathological State: Cancer

26
Hyperactive delta isoform of PI3Kinase enables long distance regeneration of adult rat corticospinal tract

K Kristyna, P Zuzana, K Lydia, S Stepanka, N Bart, H Radovan, H Vit, MU Lucia, T Rostislav, KC Jessica, J van den Herik, V Joost, E Richard, FW James, J Pavla

Molecular Therapy (Cell) Czech Republic, UK, Slovakia, The Netherlands, 27 December 2024

Neuroscience

Key words: pinal cord, axon regeneration, signalling, PI3K, pS6, skilled paw reaching, electrophysiology, c-Fos

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord injury

27
Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK-mediated mitochondria protection in early diabetic retinopathy

J Liu, Y Zhang, X Xu, X Dong, Y Pan, X Sun, Y Luo

Pharmacological Research (Elsevier) China, 26 December 2024

Pharmacology

Key words: Ginsenoside Ro, Endothelial cell, Epac1/APMK pathway, Mitochondria damage, Diabetic retinopathy

Organism: Mouse

Tissue: Eye

Pathological State: Diabetes

28
Exploring the Effects of Imidacloprid on Liver Health and the Microbiome in Rats: A Comprehensive Study

AT Qumsani

Microorganisms (MDPI) Saudi Arabia, 25 December 2024

Hepathology

Key words: imidacloprid; liver function; gut microbiome; microbial diversity; environmental and human health; dysbiosis

Organism: Rat

Tissue: Liver

Pathological State: Inflammation

29
Fusobacterium sphaericum sp. nov., isolated from a human colon tumor adheres to colonic epithelial cells and induces IL-8 secretion

MA Zepeda-Rivera, Y Eisele, A Baryiames, H Wu, C Mengoni, G Piccinno, EF McMahon, KD LaCourse, DS Jones, H Hauner, SS Minot, N Segata, FE Dewhirst, CD Johnston, S Bullman

Gut Microbes (Taylor & Francis) USA, Germany, Italy, 25 December 2024

Bacteriology

Key words: Fusobacterium, novel species, pangenome, comparative genomics, intestinal microbiota, colorectal cancer

Organism: Bacteria

Cell Line: Fusobacterium Sphaericum

30
Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding Normal Cells

Y Wang, X Sun, R Ma, X Zhang, S Ji, Z Liu, G Yang, H Wang, P Zhang, J Zhang, J Tian

Cancer Medicine (Wiley Online Library) China, 23 December 2024

Oncology

Key words: glioblastoma, inhibitor of PRMT5/MTA, MTAP-deleted, synthetic lethal hypothesis

Organism: Human

Tissue: Brain

Pathological State: Cancer

31
Astragalus Polysaccharide Mitigates Rhabdomyolysis-Induced Acute Kidney Injury via Inhibition of M1 Macrophage Polarization and the cGAS-STING Pathway

C Sun, X Zhao, X Wang, Y Yu, H Shi, J Tang, S Sun, S Zhu

Journal of Inflammation Research (Taylor & Francis) China, 22 December 2024

Nephrology

Key words: astragalus polysaccharide, macrophages, rhabdomyolysis-induced acute kidney injury, cGAS-STING pathway

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

32
Adequate post-ischemic reperfusion of the mouse brain requires endothelial NFAT5

R Kunze, P Wacker, P Breuer, E Nasyrov, IM Kur, A Weigert, AH Wagner, HH Marti, T Korff

Acta Neuropathologica Communications (Springer) Germany, 22 December 2024

Neuroscience

Key words: NFAT5, KCNJ2, Endothelial cells, Ischemic stroke, Reperfusion

Organism: Mouse

Tissue: Brain

Pathological State: Ischemia

33
Impact of c-JUN deficiency on thalamus development in mice and human neural models

J Shi, Q Chen, J Lai, J Zhu, R Zhang, A Mazid, D Li, H Su, D Qin

Cell & Bioscience (BMC) China, 20 December 2024

Neuroscience

Key words: c-JUN, AP-1, NPC, Cerebral organoids, Thalamus organoids, Neural development

Organism: Mouse

Tissue: Brain

Pathological State: Protein Injection

34
Perforated imprinting on high moisture meat analogue confers long range mechanical anisotropy resembling meat cuts

X Lou, J Wang, LG Kwang, H Zhou, FYT Ong, S Ng, H Yu

npj Science of Food (Nature) Singapore, 20 December 2024

Foodscience

Key words: Biomaterials – proteins, Technology

35
Targeting the Calcium-Sensing Receptor in Chemically Induced Medium-Grade Colitis in Female BALB/C Mice

K Piatek, V Gushchina, A Kleinwächter, N Kupper, I Mesteri, T Elajnaf, L Iamartino, M Salzmann, C Müller, T Manhardt, A Vlasaty, E Kallay, M Schepelmann

Nutrients (MDPI) Austria, Germany, UK, 18 December 2024

Neuroscience, Gastroenterology

Key words: calcium-sensing receptor; calcium; inflammatory bowel disease; colitis; NPS 2143

Organism: Mouse

Tissue: Intestine

Pathological State: Colitis

36
Plasma CircCYP24A1 as a Novel Biomarker of Esophageal Squamous Cell Carcinoma

R Zhang, J Liu, H Yang, J Tan, R Xiong, Y Liu, G Feng, G Song, K Liu

Technology in Cancer Research & Treatment (Sage Journals) China, 18 December 2024

Oncology

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

37
Metabolic shifts in lipid utilization and reciprocal interactions within the lung metastatic niche of triple-negative breast cancer revealed by spatial multi-omics

JY Kan, HC Lee, MF Hou, HP Tsai, SF Jian, , CY Chang, PH Tsai, YS Lin, YM Tsai, KL Wu, YC Huang, YL Hsu

Cell Death & Disease (Nature) Taiwan, 18 December 2024

Oncology

Key words: Cancer metabolism, Transcriptomics

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

38
Induced pluripotent stem cells (iPSCs) as a cellular therapy for post-traumatic osteoarthritis in a murine model

J Cha

(University of Calgary) Canada, 18 December 2024

Osteology

Organism: Mouse

Tissue: Knee

Pathological State: Arthritis

39
High-intensity interval training or lactate administration combined with aerobic training enhances visceral fat loss while promoting VMH neuroplasticity in female rats

B Cheng, J Du, S Tian, Z Zhang, W Chen, Y Liu

Lipids in Health and Disease (BMC) China, 18 December 2024

Sport Science

Key words: High-intensity interval training, Lactate, Visceral fat, VMH, LFPs

Organism: Rat

Tissue: Brain

40
Human decellularized adipose matrix derived hydrogel facilitates human umbilical cord-derived mesenchymal stem cells delivery with clinical translational potential value in accelerating wound healing

Z Chen, L He, Y Li, J Shu, Q Zeng, J Xi, M Chen

Colloids and Surfaces A: Physicochemical and Engineering Aspects (Elsevier) China, 17 December 2024

Regenerative Medicine

Key words: Adipose tissue, Decellularized matrix hydrogel, Human umbilical cord-derived mesenchymal, stem cells, Stem cell therapy, Wound healing

Organism: Pig

Tissue: Skin

Pathological State: Wound

41
Single-cell RNA sequencing of chronic idiopathic erythroderma defines disease-specific markers

S Chennareddy, K Rindler, S Meledathu, MP Naidu, N Alkon, JR Ruggiero, L Szmolyan, W Weninger, WM Bauer, J Griss, C Jonak, PM Brunner

Journal of Allergy and Clinical Immunology (Elsevier) USA, Austria, 16 December 2024

Dermatology

Organism: Human

Tissue: Skin

Pathological State: Inflammation

42
Atlas of Normal Articular Cartilage: Structural and Functional Comparison Across Species

OO Oduba

(University of Calgary) Canada, 16 December 2024

Osteology

Organism: Mouse, Rat, Chicken

Tissue: Bone

Pathological State: Arthritis

43
Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma

T Li, Z Zhao, M Peng, L Zhang, C Wang, F Luo, M Zeng, K Sun, Z Fang, Y Luo, Y Xie, C Lv, J Wang, JD Huang, H Zhou, H Sun

mSystems (ASM Journals) China, 11 December 2024

Oncology

Organism: Human

Tissue: Brain

Pathological State: Cancer

44
Impacts of Gestational F-53B Exposure on Fetal Neurodevelopment: Insights from Placental and Thyroid Hormone Disruption

S Zhao, Y Sun, J Duan, T Zhang, Y Xiao, Y Zhu, Y Jia, W Zhong, L Zhu

Environment & Health (ACS Publications) China, 11 December 2024

Reproductive Medicine

Key words: F-53B, thyroid hormone, placental development, neurotoxicity, DNA methylation

Organism: Mouse

Tissue: Brain

Pathological State: Chemical Exposure

45
Colchicine Alleviates Interstitial Lung Disease in an Experimental Autoimmune Myositis Murine Model by Inhibiting the Formation of Neutrophil Extracellular Traps

F Li, P Zhao, L Zhao, L Bai, Q Su, Y Feng, W Ma, J Zhu, J Yang, S Zhang

Inflammation (Springer) China, 11 December 2024

Pulmonology

Key words: Interstitial lung disease, Experimental autoimmune myositis, Colchicine, Neutrophil extracellular traps, Pyroptosis

Organism: Mouse, Rat

Tissue: Lung

Pathological State: Interstitial lung disease

46
Developmental and adult striatal patterning of nociceptin ligand marks striosomal population with direct dopamine projections

E Hueske, C Stine, T Yoshida, JR Crittenden, A Gupta, JC Johnson, AS Achanta, S Bhagavatula, J Loftus, A Mahar, D Hu, J Azocar, RJ Gray, MR Bruchas, AM Graybiel

Journal of Comparative Neurology (Wiley Online Library) USA, 10 December 2024

Neuroscience

Organism: Mouse

Tissue: Brain

47
Novel biomarkers: the RUNX family as prognostic predictors in colorectal cancer

Y Liu, J Chen, A Li, Y Wu, J Ge, M Yuan, B Xu, X Zheng, L Chen, J Jiang

Frontiers in Immunology (Frontiers Media SA) China, 09 December 2024

Oncology

Key words: RUNX, tumor-infiltrating CD8+T cells, multi-color immunohistochemical staining, colorectal cancer, prognosis

Organism: Human

Tissue: Colon

Pathological State: Cancer

48
Protective effect of trehalose on sperm chromatin condensation failure and semen quality decline in BDE-209-exposed mice

X Gao, H He, Q Zheng, S Chen, Y Wei, T Zhang, Y Wang, B Wang, D Huang, S Zhang, S Zhang, J Zhai

Food and Chemical Toxicology (Elsevier) China, 08 December 2024

Reproductive Medicine

Key words: Deca-bromodiphenyl ether (BDE-209), Histone-to-protamine exchange, Autophagy, Semen parameters, AMPK

Organism: Mouse

Tissue: Testis

Pathological State: Chemical Exposure

49
Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia

R Ma, AD Prigge, TPO Serrano, Y Cheng, JM Davis, KF Lou, WA Wood, HC Do, Z Ren, MM Fulcer, MJ Lotesto, BD Singer, BM Coates, KM Ridge

Cell reports (Cell) USA, 07 December 2024

Pulmonology

Key words: regulatory T cells, Tregs, vimentin, distal pole complex, IL-18R, AREG, epidermal growth factor receptor, viral pneumonia, lung injury, lung repair

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

50
Modulation of Biomaterial‐Associated Fibrosis by Means of Combined Physicochemical Material Properties

LE Tromp, TAB van der Boon, RHJ de Hilster, R Bank, P van Rijn

Advanced Science (Wiley Online Library) The Netherlands, 06 December 2024

Transplantation Medicine

Organism: Human

Pathological State: Medical Implant

Cell Line: C-12302

51
Programming tissue-sensing T cells that deliver therapies to the brain

MS Simic, PB Watchmaker, S Gupta, Y Wang, SA Sagan, J Duecker, C Shepherd, D Diebold, P Pineo-Cavanaugh, J Haegelin, R Zhu, B Ng, W Yu, Y Tonai, L Cardarelli, NR Reddy, SS Sidhu, O Troyanskaya, SL Hauser, MR Wilson, SS Zamvil, H Okada, WA Lim

Science (Science) USA, 06 December 2024

Neuroscience

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

52
SGLT2 inhibitor downregulates ANGPTL4 to mitigate pathological aging of cardiomyocytes induced by type 2 diabetes

Y Wen, X Zhang, H Liu, H Ye, R Wang, C Ma, T Duo, J Wang, X Yang, M Yu, Y Wang, L Wu, Y Zhao, L Wang

Cardiovascular Diabetology (BMC) China, 04 December 2024

Cardiology

Key words: SGLT2i, Diabetic cardiomyopathy, Cellular senescence, ANGPTL4, FOXO1

Organism: Mouse

Tissue: Heart

Pathological State: Diabetes

53
Expression of Neurotrophins and Its Receptors During Fetal Development in the Human Cochlea

C Steinacher, Sy Nishio, Si Usami, J Dudas, D Rieder, HA Rask-Andersen, B Crespo, N Moreno, M Konschake, C Seifarth, R Glueckert

International Journal of Molecular Sciences (MDPI) Austria, Japan, Sweden, UK, 03 December 2024

Reproductive Medicine

Key words: human inner ear, BDNF, NT-3, NT-4, Trk receptor, p75, neurotrophins, development, hearing

Organism: Human

Tissue: Ear

54
Distinct structural and functional connectivity of genetically segregated thalamoreticular subnetworks

ND Hartley, A Krol, S Choi, N Rome, K Levandowski, S Pasqualoni, C Jones, J Tian, S Lee, H Lee, R Kast, G Feng, Z Fu

Cell Reports (Cell) USA, 03 December 2024

Neuroscience

Key words: thalamic reticular nucleus, TRN, thalamocortical circuits, TRN subnetwork synaptic connectivity, electrophysiology, EEG, neuropsychiatric disorders, neurodevelopmental disorders

Organism: Mouse

Tissue: Brain

Pathological State: Viral Infection

55
The inhibition of PINK1/Drp1-mediated mitophagy by hyperglycemia leads to impaired osteoblastogenesis in diabetes

Xj Chen, Yy Yang, Zc Pan, Jz Xu, T Jiang, Ll Zhang, Kc Zhu, D Zhang, Jx Song, Cx Sheng, Lh Sun, B Tao, Jm Liu, Hy Zhao

iScience (Cell) China, 02 December 2024

Osteology

Organism: Mouse

Tissue: Bone

Pathological State: Diabetes

56
Anti-BAFF-Behandlung verringert Transplantatfibrose und DKK3-Expression im Modell der Nonadhärenz bei experimenteller Nierentransplantation in der Ratte

A Preiß

(Universität Regensburg) Germany, 02 December 2024

Nephrology

Organism: Rat

Tissue: Kidney

Pathological State: Organ Transplantation

57
398 A crosstalk of CD8+ resident memory T cells and skin Dendritic cells protects organ transplant receivers from skin cancer development

S Saluzzo, L Borik-Heil, L Gail, RV Pandey, A Aguilar-Gonzales, G Stary

Journal of Investigative Dermatology (Elsevier) Austria, 01 December 2024

Dermatology, Oncology

Organism: Human

Tissue: Skin

Pathological State: Cancer

58
MORPHOLOGICAL CHANGES IN LEYDIG TM3 CELLS INDUCED BY NEONICOTINOID ACETAMIPRID

L Zuščíková, H Greifová, A Kováčik, N Lukáč, Ľubica Libová, Tomáš Jambor

Journal of Microbiology Biotechnology and Food Sciences (Faculty of Biotechnology and Food Sciences) Slovakia, 01 December 2024

Reproductive Medicine

Key words: acetamiprid, Leydig cells, 3D-cultivation, morphology

Organism: Mouse

Pathological State: Chemical Exposure

Cell Line: Leydig TM3

59
GsMTx4 Combined with Exercise Exerts Neuroprotective Effects by Regulating Neuronal Autophagy in Rats with Spinal Cord Injury

Q Li, C Li, X Li, X Liu, J Qian, J Li, X Li, X Zhang

Neurochemical Research (Springer) China, 29 November 2024

Neuroscience

Key words: Spinal cord injury, GsMTx4, Exercise, Autophagy, Nerve repair

60
Enhanced and sustained biodistribution of HIV-1 neutralizing antibody VRC01LS in human genital and rectal mucosa

MP Lemos, RD Astronomo, Y Huang, S Narpala, M Prabhakaran, P Mann, CA Paez, Y Lu, GJ Mize, H Glantz, K Westerberg, H Colegrove, KS Smythe, M Lin, RH Pierce, J Hutter, I Frank, JR Mascola, AB McDermott, LG Bekker, MJ McElrath

Nature Communications (Nature) USA, South Africa, 28 November 2024

Virology

Key words: HIV infections, Immunization, Mucosal immunology, Translational immunology

Organism: Human

Tissue: Rectum

Pathological State: Viral Infection

61
Carbonic anhydrase 2 facilitates sorafenib resistance by counteracting MCT4-mediated intracellular pH dysregulation in HCC

H Lu, H Liu, R Yan, W Ma, H Liu, R Liu, Y Sun, L Ye, P Gao, W Jia, P Zhang, H Zhang

Cell Reports (Cell) China, 27 November 2024

Oncology

Key words: Sorafenib resistance, Hepatocellular carcinoma, HCC organoids, Intracellular pH homeostasis, CA2

Organism: Human

Tissue: Liver

Pathological State: Cancer

62
The Distinct Biological Effects of 6-Hydroxy-L-Nicotine in Representative Cancer Cell Lines

PA Postu, RS Boiangiu, M Mihasan, AB Stache, A Tiron, L Hritcu

Molecules (MDPI) Romania, 26 November 2024

Oncology

Key words: 6-hydroxy-L-nicotine, nicotine, nicotinic receptors, cancer

Organism: Human

Pathological State: Cancer

Cell Line: 16HBE14o 

63
SIRT1-dependent regulation of mitochondrial metabolism participates in miR-30a-5p-mediated cardiac remodeling post-myocardial infarction

G Wang, D Liu, TM Al-Masri, CC Otto, J Siveke, SA Lang, TF Ulmer, SWMO Damink, T Luedde, E Dahl, UP Neumann, LR Heij, J Bednarsch

Journal of Clinical and Experimental Hepatology (Elsevier) Germany, The Netherlands, 25 November 2024

Oncology

Key words: cholangiocellular carcinoma, immune cells, body composition, oncological outcome

Organism: Human

Tissue: Liver

Pathological State: Cancer

64
Identification of prognostic tumor microenvironment in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy combined with lenvatinib and PD-1 inhibitors

S Chen, L Zhao, Z Wu, H Cai, F Wang, L Wu, H Sun, W Guo

International Immunopharmacology (Elsevier) China, 23 November 2024

Oncology

Key words: Tumor microenvironment, HCC, HAIC, Lenvatinib, Programmed cell death protein-1

Organism: Human

Tissue: Liver

Pathological State: Cancer

65
Weekly Intraperitoneal Injection of Tamoxifen in an Inducible in vivo Model of Junctional Epidermolysis Bullosa Generates Early and Advanced Disease Phenotypes

EM Jones, P Garcha, M Aumailley, EA O'Toole, E Rognoni, M Caley

JID Innovations (Elsevier) UK, Germany, 22 November 2024

Dermatology

Key words: Junctional EB, Laminin, skin inflammation, inducible transgenic model

Organism: Mouse

Tissue: Skin

Pathological State: Junctional Epidermolysis Bullosa

66
Multimodal single cell-resolved spatial proteomics reveal pancreatic tumor heterogeneity

Y Xu, X Wang, Y Li, Y Mao, Y Su, Y Mao, Y Yang, W Gao, C Fu, W Chen, X Ye, F Liang, P Bai, Y Sun, S Li, R Xu, R Tian

Nature Communications (Nature) China, 21 November 2024

Oncology

Key words: Cancer microenvironment, Imaging, Proteomic analysis, Proteomics

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

67
Early and late place cells during postnatal development of the hippocampus

C Wang, H Yang, S Chen, C Wang, X Chen

Nature Communications (Nature) China, 21 November 2024

Neuroscience

Key words: Hippocampus, Spatial memory

Organism: Rat

Tissue: Brain

Pathological State: Viral Infection

68
Amino Acids Fueling Fibroblast‐Like Synoviocyte Activation and Arthritis By Regulating Chemokine Expression and Leukocyte Migration

T Karonitsch, V Saferding, M Kieler, Kv Dalwigk, A Tosevska, G Heller, M Dellinger, B Niederreiter, F Kartnig, CW Steiner, P Georgel, HP Kiener, JS Smolen, AP Korb-Pap, M Bonelli, D Aletaha, S Blüml

Arthritis & Rheumatology (Wiley Online Library) Austria, France, Germany, 20 November 2024

Osteology

Organism: Human

Tissue: Synovial Joint

Pathological State: Arthritis

69
Uncovering the predictive and immunomodulatory potential of transient receptor potential melastatin family-related CCNE1 in pan-cancer

N Zhang, H Zhang, S Li, W Wu, P Luo, Z Liu, Y Chen, Z Xia, C Huang, Q Cheng

Molecular Cancer (Springer) China, 18 November 2024

Oncology

Key words: CCNE1, Cancer immunotherapy, TRPM family, Macrophage, Tumor microenvironment

Organism: Human

Tissue: Liver, Skin, Lung, Kidney, Stomach,

Pathological State: Cancer

70
Effects of particulate air pollution on BPDE-DNA adducts, telomere length, and mitochondrial DNA copy number in human exhaled breath condensate and BEAS-2B cells

N Pedklang, P Navasumrit, C Chompoobut, J Promvijit, P Hunsonti, M Ruchirawat

International Journal of Hygiene and Eviormental Health (Elsevier) Thailand, 18 November 2024

Enviormental Biology

Key words: Particulate matter, Polycyclic aromatic hydrocarbon, Exhaled breath condensate, BPDE-DNA adduct, Telomere length, Mitochondrial DNA copy number

Organism: Human

Pathological State: Chemical Exposure

Cell Line: BEAS-2B

71
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment

R Li, J Strobl, EFM Poyner, A Balbaa, F Torabi, PV Mazin, NJ Chipampe, E Stephenson, CS Ramírez-Suástegi, VBM Shanmugiah, L Gardner, B Olabi, R Coulthard, RA Botting, N Zila, E Prigmore, NH Gopee, MA Chroscik, E Kritikaki, J Engelbert, I Goh, HM Chan, HF Johnson, J Ellis, V Rowe, W Tun, G Reynolds, D Yang, AR Foster, L Gambardella, E Winheim, C Admane, B Rumney, L Steele, L Jardine, J Nenonen, K Pickard, J Lumley, P Hampton, S Hu, F Liu, X Liu, D Horsfall, DL Basurto-Lozada, L Grimble, CM Bacon, SC Weatherhead, H Brauner, Y Wang, F Bai, NJ Reynolds, JE Allen, C Jonak, PM Brunner, SA Teichmann

Nature Immunology (Nature) USA, UK, Austria, Sweden, China, 18 November 2024

Oncology

Key words: Sequencing, Tumour immunology

Organism: Human

Tissue: Skin

Pathological State: Cancer

72
YAP enhances mitochondrial OXPHOS in tumor-infiltrating Treg through upregulating Lars2 on stiff matrix

J Bai, M Yan, Y Xu, Y Wang, Y Yao, P Jin, Y Zhang, Y Qu, L Niu, H Li

Journal for ImmunoTherapy of Cancer (BMJ) China, 17 November 2024

Oncology

Key words: Solid tumor, T regulatory cell - Treg, Extracellular Matrix, Mitochondria

Organism: Human

Tissue: Stomach

Pathological State: Cancer

73
Body composition in cholangiocarcinoma affects immune cell populations in the tumor and normal liver parenchyma

C Wu, YX Hong, XC Zhang, JZ Li, YT Li, J Xie, RY Wang, Y Wang, G Li

Free Radical Biology and Medicine (Elsevier) China, 16 November 2024

Cardiology

Key words: miR-30a-5p, Myocardial infarction, SIRT1, Mitochondrial metabolism

Organism: Mouse

Tissue: Heart

Pathological State: Mycardial Infarction

74
Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity

Z Zhang, C Ren, R Xiao, S Ma, H Liu, Y Dou, Y Fan, S Wang, P Zhan, C Gao, X Yue, C Li, L Gao, X Liang, Z Wu, C Ma

Science Immunology (Science) China, 15 November 2024

Immunology

Organism: Human

Tissue: Liver

Pathological State: Cancer

75
Fas Apoptosis Inhibitory Molecule 2 Inhibits Pathological Cardiac Hypertrophy by Regulating the MAPK Signaling Pathway

H Zhong, M Wu, H Xie, X Chen, J Li, Z Duan, H Chen, Z Liu, W Liao, Y Chen

Journal of the Ameriacan Heart Association (AHA Journals) China, 15 November 2024

Cardiology

Organism: Rat

Tissue: Heart

Pathological State: Hyperthropy

76
Integrated proteomics and scRNA-seq analyses of ovarian cancer reveal molecular subtype-associated cell landscapes and immunotherapy targets

R Tan, M Wen, W Yang, D Zhan, N Zheng, M Liu, F Zhu, X Chen, M Wang, S Yang, B Xie, Q He, K Yuan, L Sun, Y Wang, J Qin, Y Zhang

British Journal of Cancer (Nature) China, 15 November 2024

Oncology

Key words: Cancer immunotherapy, Ovarian cancer, Proteome informatics, Target identification, Targeted therapies

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

77
BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice With Loss of the Polarity Protein Par3

R Wang, XR Yang, XM Zhang, JJ Wei, SF Wu, H Gu, Q Fu, JH Guo, YL Li

Immunity & Ageing (BMC) China, 14 November 2024

Neuroscience

Key words: Aging-associated cognitive decline, Cognitive heterogeneity, Microglial activation, Th17/Treg cells, Inflammation

Organism: Rat

Tissue: Brain

Pathological State: Inflammation

78
A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer

LAC Devilee

(Queensland University of Technology) Australia, 14 November 2024

Cardiology

Key words: Heart regeneration, cardiac maturation, cardiomyocyte proliferation, ectothermy, endothermy, energy, metabolism, human cardiac organoids

Organism: Human

Tissue: Heart

79
Development and evaluation of an autism pig model

S Qiu, J Jia, B Xu, N Wu, H Cao, S Xie, J Cui, J Ma, YH Pan, XB Yuan

Lab Animal (Nature) China, 12 November 2024

Neuroscience

Key words: Autism spectrum disorders

Organism: Pig

Tissue: Brain

Pathological State: Autism

80
BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti-PD-1/PD-L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity

Y Zhan, C Huang, R Wang, X Xiao, X Xu, C Gao

Cancer Cell International (Springer) China, 07 November 2024

Oncology

Key words: MGAT5, Colorectal Cancer, Metastasis, ZO-1, EMT

Organism: Human

Tissue: Colon

Pathological State: Cancer

81
High frequency of point mutations in the nitroreductase 4 and 6 genes of Trichomonas vaginalis associated with metronidazole resistance

I Iturrieta-González, P Olivares-Ferretti, A Hidalgo, F Zambrano, X Ossa, F Fonseca-Salamanca

Folia Parasitologica (Czech Academy of Sciences) Chile, 07 November 2024

Parasitology

Key words: genital infection, trichomoniasis, refractory treatment, protein polymorphism, dysfunctional enzyme, clinical samples

Organism: Human

Tissue: Vagina

Pathological State: Infection

82
In vitro and in vivo investigation of the inhibitory effects of Sinoporphyrin sodium-mediated Sonodynamic therapy on human oral squamous cell carcinoma

S Srinivasan, T Kryza, N Bock, BWC Tse, KA Sokolowski, P Janaththani, A Fernando, L Moya, C Stephens, Y Dong, J Röhl, S Alinezhad, I Vela, JLK Perry-Keene, K Buzacott, R Nica, I Study, MD Gago-Dominguez, PSS Committee, J Schleutker, C Maier, K Muir, CM Tangen, H Gronberg, N Pashayan, D Albanes, A Wolk, JL Stanford, SI Berndt, LA Mucci, S Koutros, O Cussenot, KD Sorensen, EM Grindedal, RC Travis, CA Haiman, RJ MacInnis, A Vega, F Wiklund, DE Neal, M Kogevinas, KL Penney, BG Nordestgaard, H Brenner, EM John, M Gamulin, F Claessens, O Melander, A Dahlin, P Stattin, G Hallmans, C Häggström, R Johansson, E Thysell, AC Rönn, W Li, N Brown, G Dimeski, B Shepherd, T Dadaev, MN Brook, AB Spurdle, UH

Nature Communications (Nature) Australia, Austria, Spain, Finland, UK, Sweden, USA, France, Denmark, Germany, Belgium, 06 November 2024

Oncology

Key words: Cancer genetics, Genetic association study, Prostate cancer, Proteases, Tumour biomarkers

Organism: Human

Tissue: Prostate

Pathological State: Cancer

83
Heterogeneous Patterns of Endothelial NF-κB p65 and MAPK c-Jun Activation, Adhesion Molecule Expression, and Leukocyte Recruitment in Lung Microvasculature of Mice with Sepsis

PH Chung, FH Lin, IH Liu

International Journal of Biological Macromolecules (Elsevier) Taiwan, 04 November 2024

Osteology

Key words: HS-GAG, Heparinase III enzyme, BM-MSC, Intrinsic TGF-β signaling, Chondrogenesis, Self-renewal activity, Immunosuppressive potential

Organism: Mouse

Tissue: Bone

Pathological State: Arthritis

84
Versatility of fluorescent nanodiamonds as free radical quantum sensors: from arthritis and metastasis to potential applications in heart diseases

G Dong, L Jia, S Gao, M Lin, R Wang, F Yang, J Ruanm Y Lv

Journal of Photochemistry & Photobiology (Elsevier) China, 04 November 2024

Oncology

Key words: Autophagy ,Human oral squamous cell carcinoma, Mitochondrial apoptosis, Sinoporphyrin sodium, Sonodynamic therapy

Organism: Human

Pathological State: Cancer

Cell Line: SCC- 154

85
TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in gastric cancer

B Zhao, C Wang, M Sun, X Ma, Q Zeng, J Xi, J Zhou, X Pei, Y Jia, W Yue

Biomaterials (Elsevier) China, 03 November 2024

Neuroscience

Key words: Umbilical cord-derived mesenchymal stem cells, Biomimetic microniche, Advantageous properties, Acute brain inflammation, Neuroinflammation, Microglia

Organism: Mouse

Tissue: Brain

Pathological State: Inflammation

86
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke

R Wang, X Zhang, H Ye, X Yang, Y Zhao, L Wu, H Liu, Y Wen, Y Wang, M Yu, C Ma, L Wang

Cardiovascular Diabetology (Springer) China, 02 November 2024

Cardiology

Key words: Diabetic cardiomyopathy, Ferroptosis, FGF21, Ferritin, ATF4, Type 2 diabetes mellitus

Organism: Mouse

Tissue: Heart

Pathological State: Diabetes

87
UC-MSCs based on biomimetic microniche exert excellent regulatory effects on acute brain inflammation through advantageous properties

H Yang, L Ding, B Xu, Z Zhang, W Dai, T He, L Liu, X Du, X Fu

International Journal of Biological Macromolecules (Elsevier) China, 02 November 2024

Reproductive Medicine

Key words: Di-(2-ethylhexyl)phthalate, Lycium Barbarum polysaccharide, Sertoli cells, Ferroptosis, NRF2/SLC7A11/GPX4 pathway

Organism: Mouse

Tissue: Testis

Pathological State: Ferroptosis

88
Rational development of fingolimod nano-embedded microparticles as nose-to-brain neuroprotective therapy for ischemic stroke

L Zhao, Y Chen, Y Wang, Z Li, Q Zhang, B Gou

Chinese Journal of Tissue Engineering Research (CJTER) China, 02 November 2024

Pharmacology

Key words: myofascial pain syndrome, myofascial trigger points, stagnant moving needle, central analgesia, brain-derived neurotrophic factor, periaqueductal gray

Organism: Rat

Tissue: Brain

89
Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway

Q Geng, W Wu, M Yang, F Gu, W Cai, Y Qin, L Wie, H Wang, N Li,

Heliyon (Cell) China, 01 November 2024

Osteology

Key words: Guilu Erxian glue, Chondrocyte, Apoptosis, Knee osteoarthritis, ATF6/GRP78/CHOP signaling pathway

Organism: Rat

Pathological State: Arthritis

Cell Line: Chondrocytes

90
Dual targeting macrophages and microglia is a therapeutic vulnerability in models of PTEN-deficient glioblastoma

X Zhang, G Su, Z Shao, HW Chan, S Li, S Chow, CK Tsang, SF Chow

Drug Delivery and Translational Research (Springer) China, 01 November 2024

Neuroscience

Key words: Nose-to-brain drug delivery, Neuroprotection, Ischemic stroke, Fingolimod, Nanoparticles, Particle engineering, Nasal powder

Organism: Mouse

Tissue: Brain

Pathological State: Ischemia

91
High glucose-induced senescence contributes to tubular epithelial cell damage in diabetic nephropathy

YF Chiang, KC Huang, TC Huang, HY Chen, M Ali, A Al-Hendy, PS Huang, SM Hsia

Redox Biology (Elsevier) Taiwan, 31 October 2024

Reproductive Medicine

Key words: Uterine leiomyoma, NAMPT, NAD, Extracellular matrix

Organism: Human

Tissue: Uterus

Pathological State: Uterine Leiomyoma

92
How the extra X chromosome impairs the development of male fetal germ cells

Y Lu, M Qin, Q He, L Hua, X Qi, M Yang, Q Guo, X Liu, Z Zhang, F Xu, L Ding, Y Wu, C Zhang, D Zhai, Q Liu, J Li, P Yuan, X Shi, X Wang, C Zhao, Y Lian, R Li, Y Wie, L Yan, P Yuan, J Qiao

Nature (Nature) China, 30 October 2024

Reproductive Medicine

Key words: Disease Model, Embryonic germ cells

Organism: Human

Tissue: Gonad

Pathological State: Klinefelter syndrome

93
Unravelling the role of the tumour microenvironment in follicular lymphoma progression through characterisation of the mutational, transcriptomic and spatial immune landscape

C Zhang, Q Wu, H Yang, H Zhang, C Liu, B Yang, Q Hu

Communications Biology (Nature) China, 30 October 2024

Oncology

Key words: Molecular medicine, Non-small-cell lung cancer, Prognostic markers

Organism: Human

Tissue: Lung

Pathological State: Cancer

94
Spinal cord neural stem cells derived from human embryonic stem cells promote synapse regeneration and remyelination in spinal cord injury model rats

X Wang, X Hu, Y Xie, T Zhao, L Liu, C Liu

European Journal of Neuroscience (Wiley Online Library) China, 29 October 2024

Neuroscience

Key words: BAF45D, human spinal cord neural stem cells, MBP, spinal cord injury, synaptophysin

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

95
Regulatory Roles of NAMPT and NAD+ Metabolism in Uterine Leiomyoma Progression: Implications for ECM Accumulation, Stemness, and Microenvironment

D Yang, C Huang, X Guo, Y Li, J Wu, Z Zhang, S Yan, Y Xu

Frontiers in Aging Neuroscience (frontiers) China, 28 October 2024

Neuroscience

Key words: Huntington’s disease, R6/1, mutant huntingtin, retina, photoreceptor, ganglion cell, bipolar cell, optic nerve

Organism: Mouse

Tissue: Brain

Pathological State: Huntington's Diseas

96
The m5C reader protein Ybx1 promotes axon growth by regulating local translation in axons

J Yu, Y Zhang, J Zhang, P Che, G Long, Z Yang, SJ Ji

Development (The Company of Biologists) China, 28 October 2024

Neuroscience

Key words: m5Cmodification, Ybx1, Local translation in axons, Axon growth, DRG, Hippocampus

Organism: Mouse

Tissue: Brain

97
Mechanism of Mitochondrial Kinetic Imbalance and Nrf2 Signaling Pathway-Mediated Oxidative Stress in Nickel and/or Chromium-Induced Kidney Injury in Mice

CM Hsu, SY Kao, CH Yen, CE Hsiao, SF Cho, HC Wang, TJ Yeh, JS Du, MH Wang, TY Hsieh, SY Hsiao, Y Tsai, LC Hung, YC Liu, KC Chang, HH Hsiao

Oncology Letters (Spandidos Publications) Taiwan, 25 October 2024

Oncology

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

98
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR

Q Li, G Yang, B Ren, X Liu, LQ Tang, Q Shi, G Shan, X Wang

Molecular Cell (Cell) China, 25 October 2024

Biological Methods

Key words: circRNA, ZC3H14, exon-intron boundary, 3′ UTR, backsplicing, spermatogenesis, male infertility

Organism: Mouse

Tissue: Testis

Pathological State: Viral Infection

99
Humanized In Vivo Bone Tissue Engineering: In Vitro Preculture Conditions Control the Structural, Cellular, and Matrix Composition of Humanized Bone Organs

A Bessot, FM Savi, J Gunter, J Mendhi, S Amini, D Waugh, J McGovern, DW Hutmacher, N Bock

Advanced Healthcare Materials (Wiley) Australia, 23 October 2024

Tissue Engineering, Osteology

100
Differential effects of alendronate on chondrocytes, cartilage matrix and subchondral bone structure in surgically induced osteoarthritis in mice

M Ehrnsperger, S Taheri, P Pann, AF Schilling, S Grässel

Scientific Reports (Nature) Germany, 23 October 2024

Rheumatology

Key words: DMM, Osteoarthritis, Bisphosphonate, Alendronate, VDIPEN, ADAMTS-5, Subchondral bone, Cartilage, Micro/nano-CT, Osteoclasts, Chondrocytes, NK1-R, MMP-13

Organism: Mouse

Tissue: Bone

101
BiTE-Secreting CAR-γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors

M Ehrnsperger, S Taheri, P Pann, AF Schilling, Susanne Grässel

Scientific Reports (Nature) Germany, 23 October 2024

Osteology

Key words: ADAMTS-5, Alendronate, Bisphosphonate, Cartilage, Chondrocytes, DMM, MMP-13, Micro/nano-CT, NK1-R, Osteoarthritis, Osteoclasts, Subchondral bone, VDIPEN

Organism: Mouse

Tissue: Bone

Pathological State: Arthritis

102
Ferroptosis-related gene signature for predicting prognosis and identifying potential therapeutic drug in EGFR wild-type lung adenocarcinoma

A Bessot, F Medeiros Savi, J Gunter, J Mendhi, S Amini, D Waugh, J McGovern, DW Hutmacher, N Bock

Advanced Healtcare Materials (Wiley Online Library) Australia, Germany, 23 October 2024

Osteology

Organism: Mouse

Tissue: Bone

103
Prophylactic use of probiotics as an adjunctive treatment for ischemic stroke via the gut-spleen-brain axis

YH Wang, JM Liao, MS Jan, M Wang, HH Su, WH Tsai, PH Liu, YS Tsuei, SS Huang

Brain, Behavior, and Immunity (Elsevier) Taiwan, 22 October 2024

Neuroscience

Key words: Ischemic stroke, Probiotics, Gut-spleen-brain axis

Organism: Mouse

Tissue: Small Intestine

104
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex

C Zhao, T Zhang, S Xue, P Zhang, F Wang, Y Li, Y Liu, L Zhao, J Wu, Y Yan, X Mao, Y Chen, J Yuan, Z Li, K Li

Cell Metabolism (Cell Press) China, 22 October 2024

Endocrinology, Oncology

Key words: obesity, breast cancer, adipocyte, glutathione, GSH, lysosomal integral membrane protein-2, SCARB2, ARF1, mammalian target of rapamycin complex 1, mTORC1

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

105
Microbial and Transcriptomic Landscape Associated With Neutrophil Extracellular Traps in Perianal Fistulizing Crohn's Disease

D Cao, M Hu, N Yang, K Qian, J Hong, J Tang, Y Bian, C Zhang, X Wang, G Wu, H Chen, Y Zhang, Z Wang, Z Cui

Inflammatory Bowel Diseases (Oxford Academic) China, 22 October 2024

Gastroenterology, Immunology

Key words: Crohn’s disease, perianal fistula, microbiome, transcriptomics, neutrophil extracellular traps

106
IL-1β-induced epithelial cell and fibroblast transdifferentiation promotes neutrophil recruitment in chronic rhinosinusitis with nasal polyps

X Xie, P Wang, M Jin, Y Wang, L Qi, C Wu, S Guo, C Li, X Zhang, Y Yuan, X Ma, F Liu, W Liu, H Liu, C Duan, P Ye, X Li, L Borish, W Zhao, X Feng

Nature Communications (Nature) China, USA, 22 October 2024

Immunology

Key words: Chronic inflammation, Gene regulation in immune cells, Interleukins, Mucosal immunology, Respiratory tract diseases

Organism: Human

Tissue: Nasal mucosa

107
Therapeutic Effects of Engineered Exosomes from RAW264.7 Cells Overexpressing hsa-let-7i-5p against Sepsis in Mice—A Comparative Study with Human Placenta-Derived Mesenchymal Stem Cell Exosomes

D Cao, M Hu, N Yang, K Qian, J Hong, J Tang, Y Bian, C Zhang, X Wang, G Wu, H Chen, Y Zhang, Z Wang, Z Cui

Inflammatory Bowel Diseases (Oxford Academic) China, 22 October 2024

Gastroenterology

Key words: Crohn’s disease, perianal fistula, microbiome, transcriptomics, neutrophil extracellular traps

Organism: Human

Tissue: Colon

Pathological State: Crohn's Diseas

108
N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation

HJ Chuang, L Chiu, BJ Liao, CY Chang, GC Wu, YC Tseng, MY Chou, PP Hwang

Journal of Hazardous Materials (Elsevier) Taipei, 22 October 2024

Reproductive Medicine

Key words: Freshwater acidification, Energy mobilization, Energy allocation, Trade-off, Growth, Energy storage, Reproduction

Organism: Medaka Fish

Tissue: Liver

Pathological State: Acidification 

109
Eutopic and Ectopic Endometrial Interleukin-17 and Interleukin-17 Receptor Expression at the Endometrial—Myometrial Interface in Women with Adenomyosis: Possible Pathophysiology Implications

X Xie, P Wang, M Jin, Y Wang, L Qi, C Wu, S Guo, C Li, X Zhang, Y Yuan, X Ma, F Liu, W Liu, H Liu, C Duan, P Ye, X Li, L Borish, W Zhao, X Feng

Nature Communications (Nature) China, 22 October 2024

Otolaryngology

Organism: Mouse

Tissue: Nose

Pathological State: Inflammation

110
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior

CA Bento, VF Arnaud-Sampaio, T Glaser, E Adinolfi, R Coutinho-Silva, H Ulrich, C Lameu

Purinergic Signalling (Springer) Brazil, Italy, 19 October 2024

Immunology, Oncology

Key words: Tumor-associated macrophages, P2Y2 receptor, Purinergic signaling, Chemoresistance, Invasion

Cell Line: bone marrow-derived macrophages, human neuroblastoma cells

111
Optineurin regulates motor and learning behaviors by affecting dopaminergic neuron survival in mice

X Yang, R Zheng, H Zhang, Z Ou, S Wan, D Lin, J Yan, M Jin, J Tan

Experimental Neurology (Elsevier) China, 18 October 2024

Neuroscience

Key words: OPTN, Autophagy, Neurodegenerative diseases, Dopaminergic neurons

Organism: Mouse

Tissue: Brain

112
Lavender improves sleep through olfactory perception and GABAergic neurons of the central amygdala

YL Ren, WW Chu, XW Yang, L Xin, JX Gao, GZ Yan, C Wang, YN Chen, JF Xie, K Spruyt, JS Lin, YP Hou, YF Shao

Journal of Ethnopharmacology (Elsevier) China, France, 18 October 2024

Neuroscience

Key words: Lavender, Aromatherapy, Sleep, Olfactory perception, The central amygdala, Insomnia

Organism: Mouse

Tissue: Brain

113
Environmental acidification drives inter-organ energy mobilization to enhance reproductive performance in medaka (Oryzias latipes)

HJ Chuang, L Chiu, BJ Liao, CY Chang, GC Wu, YC Tseng, MY Chou, PP Hwang

Journal of Hazardous Materials (Elsevier) Taiwan, 18 October 2024

Reproductive Biology

Key words: Freshwater acidification, Energy mobilization, Energy allocation, Trade-off, Growth, Energy storage, Reproduction

Organism: Medaka Fish

114
Immune escape between endoplasmic reticulum stress-related cancer cells and exhausted CD8+T cells leads to neoadjuvant chemotherapy resistance in ovarian cancer

Z Li, L Hao, S Chen, W Fu, H Zhang, Z Yin, Y Wang, J Wang

Cellular Signalling (Elsevier) China, 18 October 2024

Osteology

Key words: Osteoarthritis, Osteoblasts, FoxC1, Piezo1, YAP

Organism: Human

Tissue: Bone

Pathological State: Arthritis

115
Proliferation und Organisation immigrierender Lymphozyten im Rahmen der Allograftabstoßung im experimentellen Nierentransplantationsmodell der Ratte

YL Ren, WW Chu, XW Yang, L Xin, JX Gao, GZ Yan, C Wang, YN Chen, JF Xie, K Spruyt, JS Lin, YP Hou, YF Shao

Journal of Ethnopharmacology (Elsevier) China, France, 18 October 2024

Neuroscience

Key words: Lavender, Aromatherapy, Sleep, Olfactory perception, The central amygdala, Insomnia

Organism: Mouse

Tissue: Brain

Pathological State: Viral Infection

116
NPS-1034 Exerts Therapeutic Efficacy in Renal Cell Carcinoma Through Multiple Targets of MET, AXL, and TNFRSF1A Signaling in a Metastatic Model

YC Chang, CT Liu, CY Yu, WW Sung

Cells (MDPI) Taiwan, 17 October 2024

Oncology, Nephrology

Key words: kidney cancer; lung metastasis; tumor necrosis factor receptor 1; tyrosine kinase inhibitor; systemic treatment

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

117
Eutopic and Ectopic Endometrial Interleukin-17 and Interleukin-17 Receptor Expression at the Endometrial—Myometrial Interface in Women with …

LT Hsu, PC Lu, YW Wang, HM Wu, IJ Chen, HY Huang

International Journal of Molecular Science (MDPI) Taiwan, 17 October 2024

Reproductive Biology

Key words: interleukin-17; adenomyosis; endometrial–myometrial interface; cytokine

Organism: Human

Tissue: Endometrium

Pathological State: Adenomyosis

118
PTGES is involved in myofibroblast differentiation via HIF‐1α‐dependent glycolysis pathway

MH Lin, YC Lee, JB Liao, CY Chou, YF Yang

Journal of Cellular and Molecular Medicine (Wiley) Taiwan, 17 October 2024

Cell Biology

Key words: fibroblast, HIF-1α, metabolic pathway, myofibroblast, PTGES

119
Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction between PTBP1 and ACTN4

YC Chang, CT Liu, CY Yu, WW Sung

Cells (MDPI) Taiwan, 17 October 2024

Oncology

Key words: kidney cancer, lung metastasis, tumor necrosis factor receptor 1, tyrosine kinase inhibitor, systemic treatment

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

120
Functional and Proteomic Dissection of the Contributions of CodY, SigB and the Hibernation Promoting Factor HPF to Interactions of Staphylococcus aureus USA300 with Human Lung Epithelial Cells

MH Lin, YC Lee, JB Liao, CY Chou, YF Yang

Journal of Cellular and Molecular Medicine (Wiley Online Library) Taiwan, 17 October 2024

Pulmonology

Organism: Rat

Tissue: Lung

Pathological State: Fibrosis

121
Single-cell transcriptomics reveals granzyme K-expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD

LT Hsu, PC Lu, YW Wang, HM Wu, IJ Chen…

International Journal of Molecular Science (MDPI) Taiwan, 17 October 2024

Reproductive Medicine

Key words: interleukin-17, adenomyosis, endometrial–myometrial interface, cytokine

Organism: Human

Tissue: Uterus

Pathological State: Adenomyosis

122
A single-dose circular RNA vaccine prevents Zika virus infection without enhancing dengue severity in mice

X Liu, Z Li, X Li, W Wu, H Jiang, Y Zheng, J Zhou, X Ye, J Lu, W Wang, L Yu, Y Li, L Qu, J Wang, F Li, L Chen, L Wu, L Feng

Nature Communications (Nature) China, 16 October 2024

Virology

Key words: RNA vaccines, Vaccines, Viral infection

Organism: Mouse

Tissue: Brain

Pathological State: Zika virus infection

123
Investigating the role of various extracellular matrix in androgenetic alopecia: Insights from immunostaining and quantitative analysis–A pilot study

X Liu, Z Li, X Li, W Wu, H Jiang, Y Zheng, J Zhou, X Ye, J Lu, W Wang, L Yu, Y Li, L Qu, J Wang, F Li, L Chen, L Wu, L Feng

Nature Communications (Nature) China, 16 October 2024

Virology

Key words: RNA vaccines, Vaccines, Viral infection

Organism: Mouse

Tissue: Brain

Pathological State: Viral Infection

124
Nivolumab plus anlotinib hydrochloride in advanced gastric adenocarcinoma and esophageal squamous cell carcinoma: the phase II OASIS trial

J Wu, S Zhang, S Yu, G An, Y Wang, YY Yu, L Liang, Y Wang, X Xu, YX Xiong, D Shao, Z Shi, N Li, J Wang, D Jin, T Liu, Y Cui

Nature Communications (Nature) China, 15 October 2024

Oncology

Key words: Cancer immunotherapy, Gastric cancer, Oesophageal cancer

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

125
Quercetin Promotes Apoptosis of Gastric Cancer Cells through the EGFR‐ERK Signaling Pathway

J Wu, S Zhang, S Yu, G An, Y Wang, Y Yu, Li Liang, Y Wang, X Xu, YS Xiong, D Schao, Z Shi, N Li, J Wang, D Jin, T Liu, Y Cui

Nature Communications (Nature) China, 15 October 2024

Oncology

Key words: Cancer immunotherapy,Gastric cancer, Oesophageal cancer

Organism: Human

Tissue: Stomach

Pathological State: Cancer

126
β-Mangostin Alleviates Renal Tubulointerstitial Fibrosis via the TGF-β1/JNK Signaling Pathway

PY Huang, YH Juan, TW Hung, YP Tsai, YH Ting, CC Lee, JP Tsai, YH Hsieh

Cells (MDPI) Taiwan, 14 October 2024

Nephrology, Molecular Biology

Key words: β-mangostin; renal tubulointerstitial fibrosis; EMT; TGF-β1; Smad2; JNK1/2

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Tubulointerstitial Fibrosis

127
CD24hiCD27+ Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer

LQ Sun, Y Bai, J Wu, SJ Fan, SY Chen, ZY Zhang, JQ Xia, SM Wang, YP Wang, P Qin, SG Li, P Xu, Z Zhao, CB Xiang, ZS Zhang

Plant Communications (Cell) China, 14 October 2024

Botany

Key words: OsNLP3, OsCEP6.1, OsNF-YA8, grain weight, grain chalkiness, rice, Oryza sativa L.

Organism: Rice

Tissue: Grain

128
Interleukin-32 producing CD8+ memory T cells and Tregs define the IDO1/PD-L1 niche in human cutaneous leishmaniasis skin lesions 2

PY Huang, YH Juan, TW Hung, YP Tsai, YH Ting, CC Lee, JP Tsai, YH Hsieh

Cells (MDPI) Taiwan, 14 October 2024

Nephrology

Key words: β-mangostin, renal tubulointerstitial fibrosis, EMT, TGF-β1, Smad2, JNK1/2

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Diseas

129
Potential role of calcium sulfate/β-tricalcium phosphate/graphene oxide nanocomposite for bone graft application_mechanical and biological analyses

YC Lu, TK Chang, TC Lin, ST Yeh, HS Lin, QP Cheng, CH Huang, HW Fang, CH Huang

Journal of Orthopaedic Surgery and Research (josr-online.biomedcentral.com) Taiwan, 12 October 2024

Biomaterials

Key words: Calcium sulfate, Β-tricalcium phosphate, Graphene oxide, Mechanical strength, Degradation rate, Criticalsized calvarial defect model

Organism: Rat

Tissue: Bone

130
Impact of cigarette smoke on inflammasome-dependent responses in human lung fibroblasts

D Xu, P Moru, K Liao, W Song, P Yang, D Zang, C Cai, H Zhou

Experimental Gerontology (Elsevier) China, 12 October 2024

Nephrology

Key words: Diabetic nephropathy, Epithelial-mesenchymal transition, Mitochondrial dysfunction, Senescence

Organism: Mouse

Tissue: Kidney

Pathological State: Diabetes

131
ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A Demethylation

YC Lu, TK Chang, TC Lin, ST Yeh, HS Lin, QP Cheng, CH Huang, HW Fang, CH Huang

Journal of Orthopaedic Surgery and Research (Springer) Taiwan, 12 October 2024

Osteology

Key words: Calcium sulfate, Β-tricalcium phosphate, Graphene oxide, Mechanical strength, Degradation rate, Critical-sized calvarial defect model

Organism: Rat

Tissue: Bone

Pathological State: Calvarial Defect

132
Tumor immune microenvironment dynamics and outcomes of prognosis in non‐muscle‐invasive bladder cancer

R Kamitani, N Tanaka, T Anno, T Murakami, T Masuda, Y Yasumizu, T Takeda, S Morita, T Kosaka, S Mikami, K Matsumoto, M Oya

Cancer Science (Wiley) Japan, 11 October 2024

Oncology

Key words: bladder cancer, FGFR3, microenvironment, PD-1, PD-L1

Organism: Human

Tissue: Bladder

Pathological State: Cancer

133
Forkhead box C1 promotes the pathology of osteoarthritis in subchondral bone osteoblasts via the Piezo1/YAP axis

Z Li, L Hao, S Chen, W Fu, H Zhang, Z Yin, Y Wang, J Wang

Cellular Signalling (Elsevier) China, 11 October 2024

Osteology

Key words: Osteoarthritis, Osteoblasts, FoxC1, Piezo1, YAP

Cell Line: Sclerotic subchondral osteoblasts

134
Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with …

DC Le, MHT Ngo, YC Kuo, SH Chen, CY Lin, TY Ling, QTT Pham, HK Au, J Myung, YH Huang

Journal of Biomedical Science (Springer) Taiwan, Vietnam, 11 October 2024

Reproductive Biology, Stem Cell Research

Key words: Placenta mesenchymal stem cell, Estrogen receptor, Primary ovarian insufficiency, Ovarian circadian rhythm disorder, Angiogenin, Exosomal miRNA

Organism: Mouse

Tissue: Ovaries

135
Characterisation of negative allosteric modulators of the calcium-sensing receptor, CaSR, for repurposing as a treatment for asthma

R Kamitani, N Tanaka, T Anno, T Murakami, T Masuda, Y Yasumizu, T Takeda, S Morita, T Kosaka, S Mikami, K Matsumoto, M Oya

Cancer Science (Wiley Online Library) Japan, 11 October 2024

Oncology

Tissue: Bladder

Pathological State: Cancer

136
Cancer-Associated Fibroblasts in Gallbladder Cancer Modify the Migration and Invasion of Gallbladder Cancer Cells

DC Le, MHT Ngo, YC Kuo, SH Chen, CY Lin, TY Ling, QTT Pham, HK Au, J Myung, YH Huang

Journal of Biomedical Science (Springer) Taiwan, Vietnam, 11 October 2024

Reproductive Medicine

Key words: Placenta mesenchymal stem cell, Estrogen receptor, Primary ovarian insufficiency, Ovarian circadian rhythm disorder, Angiogenin, Exosomal miRNA

Organism: Mouse

Tissue: Ovaries

Pathological State: Primary Ovarian Insufficiency

137
Cytarabine chemotherapy induces meibomian gland dysfunction

R Liu, J Xue, J Han, M Tu, W Wang, Z Chen, X Qian, B Xiao, L Liang

The Ocular Surface (Elsevier) China, 10 October 2024

Oncology, Ophthalmology

Key words: Cytarabine, Meibomian gland dysfunction, PPARγ, FoxO1, Oxidative stress

Organism: Mouse

Tissue: Eye

138
Influence of Decompression on the Expression of Inflammatory and Tissue Repair Biomarkers in Large Periapical Lesions

IT Lai, YH Chang, CB Chu, PL Chung, CK Hsu, CK Yang

Dermatologica Sinica (Wolters Kluwer) Taiwan, 10 October 2024

Dermatology

Key words: Androgenetic alopecia; extracellular matrix; immunohistochemical staining; scalp stiffness

Organism: Human

Tissue: Skin

Pathological State: Androgenetic Alopecia

139
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury

H Lin, C Ma, X Zhuang, S Liu, D Liu, M Zhang, Y Lu, G Zhou, C Zhang, T Wang, Z Zhang, L Lv, D Zhang, XZ Ruan, Y Xu, R Chai, X Yu, JP Sun, B Chu

Cell Metabolism (Cell Press) China, 09 October 2024

Endocrinology, Hepathology

Key words: GPR56, 17α-hydroxypregnenolone, ferroptosis, liver injury

Organism: Mouse

Tissue: Liver

Pathological State: Ferroptosis-induced liver injury

140
Enhancing intrinsic TGF-β signaling via heparan sulfate glycosaminoglycan regulation to promote mesenchymal stem cell capabilities and chondrogenesis for cartilage repair

L Wang, B Yu, J Zhang, Y Han, G Zheng

Trends in Immunotherapy (EnPress) China, 09 October 2024

Oncology

Key words: tumor associate antigen (TAA), tumor-associated autoantibodies (TAA) induced autologous tumor antibodies (iATA), neu antigens, hapten, hapten induced immunotherapy

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

141
Tumor-derived extracellular vesicles convey solute transporters to induce bioenergetic dependence shift contributing to treatment resistance

E Du, X Jia, X Li, B Zhang, Y Zhai, F Qin

BMC Molecular and Cell Biology (Springer) China, 09 October 2024

Neuroscience

Key words: Ciclopirox olamine, Retina, Ischemia/reperfusion injury, Neuroprotection

Organism: Rat

Tissue: Eye

Pathological State: Ischemia

142
Visualization of the dentogingival junction using micro‐plastination technique

J Correa-Aravena, C Panes, N Ponce, A Prado-Sanhueza, D Guzmán, B Vásquez, I Roa, C Veuthey, TS Masuko, NE Ottone

Clinical Anatomy (Wiley) Chile, Brazil, 08 October 2024

Imaging

Key words: dentin, dentogingival junction, enamel, histological stains, micro, plastination, plastinationautofluorescence

Organism: Human

Tissue: Tooth

143
Monocyte subsets in breast cancer patients under treatment with aromatase inhibitor and mucin-1 cancer vaccine

V Knöbl, L Maier, S Grasl, C Kratzer, F Winkler, V Eder, H Hayden, MA Sahagun Cortez, M Sachet, R Oehler, S Frantal, C Fesl, K Zehetner, G Pfeiler, R Bartsch, F Fitzal, CF Singer, M Filipits, M Gnant, C Brostjan

Journal of Translational Medicine (Springer) Austria, 08 October 2024

Oncology

Key words: Aromatase inhibitor, Breast cancer, Estrogen receptor, Letrozole, Monocyte, Stimuvax, Tecemotide

Organism: Human

Tissue: Breast

Pathological State: Cancer

144
Cross-Kingdom Pathogenesis of Pantoea alfalfae CQ10: Insights from Transcriptome and Proteome Analyses

V Knöbl, L Maier, S Grasl, C Kratzer, F Winkler, V Eder, H Hayden, MAS Cortez, M Sachet, R Oehler, S Frantal, C Fesl, K Zehetner, G Pfeiler, R Bartsch, F Fitzal, CF Singer, M Filipits, M Gnant, C Brostjan

Journal of Translational Medicine (Springer) Austria, 08 October 2024

Oncology

Key words: Aromatase inhibitor, Breast cancer, Estrogen receptor, Letrozole, Monocyte, Stimuvax, Tecemotide

Organism: Human

Tissue: Breast

Pathological State: Cancer

145
Antibody-Conjugated Nanodiamond Enzyme for Targeted Non-Small-Cell Lung Cancer by Regulating Oxidative Stress

X Guan, J Yang, Z Liu, G Yang, X Tian

ACS Applied Nano Materials (ACS Publications) China, 07 October 2024

Nanomedicine, Oncology

Key words: nanodiamond enzyme, nonsmall cell lung cancer, P40, ROS, TTF-1, oxidative stress

146
Phenotype remodelling of HNSCC cells in the muscle invasion environment

G Zeng, Y Shen, W Sun, H Lu, Y Liang, J Wu, G Liao

Journal of Translational Medicine (Springer) China, 07 October 2024

Oncology

Key words: Head and neck squamous cell carcinoma, Single-cell transcriptome, Spatial transcriptome, Phenotype remodelling, G0S2

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

147
Biomarker potential of nuclear Nrf2 activation in the ABC subtype of diffuse large B‑cell lymphoma

G Zeng, Y Shen, W Sun, H Lu, Y Liang, J Wu, G Liao

Journal of Translational Medicine (Springer) China, 07 October 2024

Oncology

Key words: Head and neck squamous cell carcinoma, Single-cell transcriptome, Spatial transcriptome, Phenotype remodelling, G0S2

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

148
Peripheral CD4+ T cell phenotype and brain microglial activation associated with cognitive heterogeneity in aged rats

X Guan, J Yang, Z Liu, G Yangy, X Tian

ACS Applied Nano Materials (ACS Publications) China, 07 October 2024

Biomaterials

Key words: nanodiamondenzyme, nonsmall cell lungcancer,P40,ROS,TTF-1, oxidative stress

Organism: Mouse

Tissue: Lung

Pathological State: Oxidative Stress

149
Interferon regulatory factor 7 alleviates the experimental colitis through enhancing IL-28A-mediated intestinal epithelial integrity

F Qing, H Tian, B Wang, B Xie, L Sui, X Xie, W He, T He, Y Li, L He, Q Guo, Z Liu

Journal of Translational Medicine (Springer) China, 06 October 2024

Immunology, Gastroenterology

Key words: IRF7, Colitis, IL-28A, Epithelial barrier, Interferon

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

150
Induced tumor associated autoantibodies (iTAAs) by hapten plus drugs for targeting oncogenic nuclear antigens at sentinel lymph node of pancreatic cancer

F Qing, H Tian, B Wang, B Xie, L Sui, X Xie, W He, T He, Y Li, L He, Q Guo, Z Liu

Journal of Translational Medicine (Springer) China, 06 October 2024

Gastroenterology

Key words: IRF, Colitis, IL-28A, Epithelial barrier, Interferon

Organism: Mouse

Tissue: Colon

Pathological State: Inflammation

151
Dronedarone hydrochloride inhibits gastric cancer proliferation in vitro and in vivo by targeting SRC

X Lu, W Zhang, X Yang, X Yan, Z Hussain, Q Wu…

Translational Oncology (Elsevier) China, 05 October 2024

Oncology, Pharmacology

Key words: Gastric cancer, Dronedarone hydrochloride, Cell proliferation, SRC/AKT1 signaling pathway

Organism: Human

Tissue: Stomach

Pathological State: Cancer

152
CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment

J Tao, Y Gu, Z Zhang, G Weng, Y Liu, J Ren, Y Shi, J Qiu, Y Wang, D Su, R Wang, Y Fu, T Liu, L Ye, W Luo, H Chen, G Yang, Z Cao, H Huang, J Xiao, B Ren, L You, T Zhang, Y Zhao

Journal of Experimental & Clinical Cancer Research (Springer) China, 03 October 2024

Oncology

Key words: Pancreatic cancer, Metastasis, Inflammatory reprogramming, Cancer-associated fibroblasts, Organoids, CALB2, CXCL14

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

153
Neuroprotective effect of ciclopirox olamine in retinal ischemia/reperfusion injury

S Hu, Z Wang, K Zhu, H Shi, F Qin, T Zhang, S tian, Y Ji, J Zhang, J Qin, Z She, X Zhang, P Zhang, H Li

Clinical and Molecular Hepatology (Korean Association for the Study of the Liver) China, 02 October 2024

Hepathology

Key words: USP29, MASLD, ACSL5, Fatty acid β-oxidation, Deubiquitination

Organism: Mouse

Tissue: Liver

Pathological State: Metabolic Dysfunction–Associated Fatty Liver Disease

154
Hexosaminidase B-driven cancer cell-macrophage co-dependency promotes glycolysis addiction and tumorigenesis in glioblastoma

C Zhu, X Chen, TQ Liu, L Cheng, W Cheng, P Cheng, AH Wu

Nature Communications (Nature) China, 01 October 2024

Oncology

Key words: Cancer metabolism, Cancer microenvironment, CNS cancer

Organism: Human

Tissue: Brain

Pathological State: Cancer

155
Epoxymicheliolide Reduces Radiation‐Induced Senescence and Extracellular Matrix Formation by Disrupting NF‐κB and TGF‐β/SMAD Pathways in Lung Cancer

C Zhu, X Chen, TQ Liu, L Cheng, W Cheng…

Nature Communications (Nature) China, 01 October 2024

Oncology

Key words: Cancer metabolism, Cancer microenvironment, CNS cancer

Organism: Human

Tissue: Brain

Pathological State: Cancer

156
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway

W Wang, H Li, Y Qian, M Li, M Deng, D Bi, J Zou

Investigative Ophthalmology & Visual Science (ARVO) China, 01 October 2024

Ophthalmology

Organism: Mouse

Tissue: Eye

Pathological State: Corneal Neovascularization

157
The Evolutionary Loss of Cardiac Regeneration: The Impact of the Ectotherm-to-Endotherm Transition

Y Liu, J Wu, H Najem, Y Lin, L Pang, F Khan, F Zhou, H Ali, AB Heimberger, P Chen

The Journal of Clinical Investigation (JCI) USA, 01 October 2024

Oncology

Organism: Human

Tissue: Brain

Pathological State: Cancer

158
Bioactive Matrix Scaffold of Oxidized Sacchachitin via Green Catalyst of SiliaCat TEMPO for Enhancing Bone Regeneration

MT Sheu, SY Lin, WJ Cheng, HL Lin, CM Hsieh, HO Ho, LC Chen, MH Wu

Carbohydrate Polymer Technologies and Applications (Elsevier) Taiwan, 30 September 2024

Osteology

Key words: Carboxylate groups formation, Sacchachitin, Siliacat-tempo green fabrication, Mouse osteoblastic cells, In vivo bone regeneration, Bioactive matrix scaffold

Organism: Rat

Tissue: Bone

Pathological State: Bone Damage

159
Lycium barbarum polysaccharide alleviates ferroptosis in Sertoli cells through NRF2/SLC7A11/GPX4 pathway and ameliorates DEHP-induced male reproductive damage in mice

J Hirpara, WL Thuya, SH Cheow, K Fernando, JQ Eu, L Wang, ALA Wong, ELS Fong, AB Ali, Lw Ding, W Zhuoran, YC Lim, S Pervaiz, BC Goh

Theranostics (Ivyspring) Singapore, 30 September 2024

Oncology

Key words: Extracellular Vesicles, TKI-resistance, SLC1A5, Tumor Microenvironment, metabolic reprogramming

Organism: Human

Pathological State: Cancer

Cell Line: HCC827 

160
Engineered 3D human neurovascular model of Alzheimer's disease to study vascular dysfunction

G Pavlou, S Spitz, FM Pramotton, A Tsai, BM Li, X Wang, OM Barr, EC Ko, S Zhang, SJ Ashley, A Maaser-Hecker, SH Choi, M Jorfi, RE Tanzi, RD Kamm

Biomaterials (Elsevier) USA, 28 September 2024

Neuroscience

Key words: Blood-brain barrier, Alzheimer's disease, Neurovascular unit, Perfusable 3D brain in vitro model, Amyloid-β

Pathological State: Alzheimer's disease

Cell Line: human primary brain microvascular endothelial cells

161
The epigenetic-modified downregulation of LOXL1 protein mediates EMT in bladder epithelial cells exposed to benzo [a] pyrene and its metabolite BPDE

R Zou, J Lu, X Bai, Y Yang, S Zhang, S Wu, Z Tang, K Li, X Hua

International Immunopharmacology (Elsevier) China, 27 September 2024

Oncology

Key words: Bladder Cancer, LOXL1, EMT, DNA methylation

Organism: Rat

Tissue: Bladder

Pathological State: Cancer

162
Syntheses of LSD1/HDAC Inhibitors with Demonstrated Efficacy against Colorectal Cancer: In Vitro and In Vivo Studies Including Patient-Derived Organoids

PY Chou, MJ Lai, KK Tsai, LH Cheng, YW Wu, MC Chen, SL Pan, HO Ho, K Nepali, JP Liou

Journal of Medicinal Chemistry (ACS Publications) Taiwan, 25 September 2024

Oncology

Key words: Cells, Genetics, Inhibitation, Inhibitors, Peptides and Proteins

Organism: Human

Tissue: Colon

Pathological State: Cancer

163
Application of Small Animal Ultrasound Imaging Technology for Identification of Polycystic Ovary Syndrome in a Mouse Model

M Ren, T Yang, M Liu, X Ma, B Li, ASM Al-Mughalles, X Pei, S Zhang

Biochemical and Biophysical Research Communications (Elsevier) China, 23 September 2024

Reproductive Medicine

Key words: Ultrasonography, Polycystic ovary syndrome, Letrozole, High-fat diet, Model

Organism: Mouse

Tissue: Ovaries

Pathological State: Polycystic ovary syndrome

164
Network Pharmacology and Metabolomics of Xinnaoxin Tablets for Antioxidant Stress in the Treat-ment of Coronary Heart Disease

F Gao, H Shen, Z Yang, Z Ding, X Zhao, X Liu, B Cui, XC Liu, YX Zhang, QH Guo

Current Science (currentscience.info) China, 20 September 2024

Pharmacology

Key words: Metabolomics; Xinnaoxin tablet; Coronary heart disease; Keap1-Nrf2/HO-1

Organism: Rat

Tissue: Heart

Pathological State: Coronary Heart Disease

165
Functional and Proteomic Dissection of the Contributions of CodY, SigB and the Hibernation Promoting Factor HPF to Interactions of Staphylococcus aureus USA300 …

X Li, LM Busch, S Piersma, M Wang, L Liu…

Journal of Proteome Research (ACS Publications) The Netherlands, Germany, 20 September 2024

Pulmonology

Key words: Staphylococcus aureus, SigB, CodY, SaHPF, Human Lung Epithelial Cells

Organism: Human

Tissue: Lung

Pathological State: Bacterial Infection

166
Mitoguardin-2 promotes cell proliferation by activating AKT and regulating Hippo/YAP1 signaling pathway in ovarian granulosa cells

X Li, LM Busch, S Piersma, M Wang, L Liu…

Journal of Proteome Research (ACS Publications) The Netherlands, Germany, 20 September 2024

Pulmonology

Key words: Staphylococcus aureus, SigB, CodY, SaHPF, Human Lung Epithelial Cells

Organism: Human

Tissue: Lung

Pathological State: Bacterial Infection

167
BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice with Loss of the Polarity …

MA Shields, AE Metropulos, C Spaulding, KA Alzahrani, T Hirose, S Ohno, TND Pham, HG Munshi

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) USA, Japan, 19 September 2024

Neuroscience, Gastroenterology

Key words: Par3, Inflammation, ADM, Primary Cilia, BET Inhibitors

Organism: Human

Tissue: Pancreas

Pathological State: Pancreatitis

168
Overexpression of NUDT16L1 sustains proper function of mitochondria and leads to ferroptosis insensitivity in colorectal cancer

YS Lin, YC Tsai, CJ Li, TT Wei, JL Wang, BW Lin, YN Wu, SR Wu, SC Lin, SC Lin

Redox Biology (Elsevier) Taiwan, 18 September 2024

Oncology

Organism: Human

Pathological State: Cancer

Cell Line: CRL-1790

169
Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain

H Li, Y Li, T Wang, S Li, H Liu, S Ning, W Shen, Z Zhao, H Wu

Neuroscience Bulletin (Springer) China, 15 September 2024

Neuroscience

Key words: Oxytocin receptor, RNAscope, Expression pattern, Postnatal development

Organism: Mouse

Tissue: Brain

170
Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration

SIG Moreno, F Limani, I Ludwig, C Gilbert, C Pifl, TS Hnasko, T Steinkellner

Experimental Neurology (Elsevier) Austria, USA, 15 September 2024

Neuroscience

Key words: Parkinson's disease, Alpha-synuclein, Dopamine neuron vulnerability, Adeno-associated viral vectors, Cre recombinase, Animal model of Parkinson's disease

Organism: Mouse

Tissue: Brain

Pathological State: Viral Infection

171
Integrated bioinformatics analysis and experimental validation reveal the relationship between ALOX5AP and the prognosis and immune microenvironment in glioma

CA Bento, VF Arnaud-Sampaio, T Glaser, E Adinolfi, R Coutinho-Silva, H Ulrich, C Lameu

Purinergic Signalling (Springer) Brazil, Italy, 15 September 2024

Oncology

Key words: Tumor-associated macrophages, P2Y2 receptor, Purinergic signaling , Chemoresistance, Invasion

Organism: Mouse

Tissue: Bone

Pathological State: Cancer

172
Immune Escape between Endoplasmic Reticulum Stress-Related Cancer Cells and Exhausted CD8+ T Cells Leads to Neoadjuvant Chemotherapy Resistance in …

S Zhang, Y Zhang, X Song, X Wang, L Quan, P Xu, W Song, Q Liu, X Zhou

Biochemical and Biophysical Research Communications (Elsevier) China, 14 September 2024

Oncology

Key words: Neoadjuvant chemotherapy, Endoplasmic reticulum stress, Ovarian cancer cell, Exhausted CD8+T cell, Immune escape

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

173
Advanced Electrospun Composites Based on Polycaprolactone Fibers Loaded with Micronized Tungsten Powders for Radiation Shielding

C Giuliani, I De Stefano, M Mancuso, N Fiaschini, LA Hein, DM Gattia, E Scatena, E Zenobi, CD Gaudio, F Galante, G Felici, A Rinaldi

Polymers (MDPI) Italy, 13 September 2024

Biomaterials

Key words: shielding; polycaprolactone (PCL); tungsten powder; polymer composites; electrospinning; radiation protection; aerospace; healthcare industry

Organism: Mouse

Tissue: Brain

Pathological State: Radiation

174
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy

JG Baldwin, CL Heuser-Loy, T Saha, RC Schelker, DL Slavkovic-Lukic, N Strieder, IL Hernandez-Lopez, N Rana, M Barden, F Mastrogiovanni, AS Martín-Santos, A Raimondi, P Brohawn, BW Higgs, C Gebhard, V Kapoor, WG Telford, S Gautam, M Xydia, P Beckhove, S Frischholz, K Schober, Z Kontarakis, JE Corn, M Iannacone, D Inverso, M Rehli, J Fioravanti, S Sengupta, L Gattinoni

Cell (Cell) Germany, USA, Italy, Switzerland, 13 September 2024

Immunology

Key words: mitochondrial transfer, CD8+T celss, nanotubes, cancer immunotherapy, bone marrow stromal cells, Talin 2, CAR T therapy, TCR-T therapy, TIL therapy immune metabolism

Organism: Mouse

Tissue: Bone Marrow

175
Imaging of Metabolic Activity Adaptations to UV Stress and Differentiation at Cellular Resolution in Skin and Skin Equivalents: Implications for Oxidative UV Damage

JG Baldwin, CL Heuser-Loy, T Saha, RC Schelker, DL Slavkovic-Lukic, N Strieder, IL Hernandez-Lopez, N Rana, M Barden, F Mastrogiovanni, AS Martín-Santos, A Raimondi, P Brohawn, BW Higgs, C Gebhard, V Kapoor, WG Telford, S Gautam, M Xydia, P Beckhove, S Frischholz, K Schober, Z Kontarakis, JE Corn, M Iannacone, D Inverso, M Rehli, J Fioravanti, S Sengupta, L Gattinoni

Cell (Cell) Germany, USA, Italy, Switzerland, 13 September 2024

Immunology

Key words: mitochondrial transfer, CD8+T celss, nanotubes, cancer immunotherapy, bone marrow stromal cells, Talin 2, CAR T therapy, TCR-T therapy, TIL therapy immune metabolism

Organism: Mouse

Tissue: Bone Marrow

176
Combined use of CLP290 and bumetanide alleviates neuropathic pain and its mechanism after spinal cord injury in rats

Y Pan, Z Talifu, X Wang, H Ke, C Zhang, X Xu, DG Yang, Y Yu, LJ Du, F Gao, JJ Li

CNS Neuroscience & Therapeutics (Wiley Online Library) China, 12 September 2024

Neuroscience

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

177
Bestimmung der biologisch äquivalenten Dosis für die Mikrostrahltherapie

Y Pan, Z Talifu, X Wang, H Ke, C Zhang, X Xu, DG Yang, Y Yu, LJ Du, F Gao, JJ Li

CNS Neuroscience & Therapeutics (Wiley Online Library) China, 12 September 2024

Neuroscience

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

178
滞动针干预 “激痛点” 对肌筋膜疼痛综合征模型大鼠中枢镇痛的作用机制

Z Liping, C Yifei, W Yaqian, L Thitong, T Qi, G Bo

Chinese Journal of Tissue Engineering Research (Journal of Clinical Rehabilitative Tissue Engineering Research) China, 12 September 2024

Neuroscience

Key words: myofascial pain syndrome, myofascial trigger points, stagnant moving needle, central analgesia, brain-derived neurotrophic factor, periaqueductal gray

Organism: Rat

Tissue: Muscle

Pathological State: Inflammation

179
Genome-wide characterization of dynamic DNA 5-hydroxymethylcytosine and TET2-related DNA demethylation during breast tumorigenesis

SL Wu, L Yang, C Huang, Q Li, C Ma, F Yuan, Y Zhou, X Wang, WM Tong, Y Niu, F Jin

Clinical Epigenetics (BMC) China, 11 September 2024

Oncology

Key words: Breast tumorigenesis, DNA 5-hydroxymethylcytosine, 5-methylcytosine, DNA methylation, NA demethylation, TET2, cfDNA

Organism: Human

Tissue: Breast

Pathological State: Cancer

180
Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis

J Li, S Zhang, C Li, X Zhang, Y Shan, Z Zhang, H Bo, Y Zhang

Scientific Reports (Nature) China, 10 September 2024

Physiology

Key words: Skeletal muscle fiber type, Mitochondrial biogenesis, Endurance exercise, Histone methylation, ROS, AMPK, Molecular bioloy, Physiology

Organism: Rat

Tissue: Muscle

Pathological State: Tissue

181
Integrated MRI radiomics, tumor microenvironment, and clinical risk factors for improving survival prediction in patients with glioblastomas

Q Zhou, X Ke, J Man, J Jiang, J Ren, C Xue, B Zhang, P Zhang, J Zhao, J Zhou

Strahlentherapie und Onkologie (Springer) China, 09 September 2024

Oncology

Key words: Glioblastoma, Tumor microenvironment, Prognosis, Radiomics, Prediction model

Organism: Human

Tissue: Brain

Pathological State: Cancer

182
Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer

CH Hung, SY Wu, CID Yao, HH Yeh, CC Lin, CY Chu, TY Huang, MR Shen, CH Lin, WC Su

Nature Communications (Nature) Taiwan, 09 September 2024

Oncology

Key words: Cancer therapeutic resistance, Glycobiology, Non-small-cell lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

183
Integration and competition between space and time in the hippocampus

S Chen, N Cheng, X Chen, C Wang

Neuron (Cell Press) China, 05 September 2024

Neuroscience

Key words: place cell, time cell, navigation, spatiotemporal, episodic memory

Organism: Mouse

Tissue: Brain

184
Glucocorticoid treatment increases cholesterol availability during critical illness: effect on adrenal and muscle function

LD Bruyn, A Téblick, TV Oudenhove, SV Perre, I Derese, L Pauwels, S Derde, GD Vlieger, GVd Berghe, L Langouche

Critical Care (BMC) Belgium, 05 September 2024

Immunology

Key words: Sepsis, Hypocholesterolemia, Muscle weakness, Adrenal failure, Aldosterone, Glucocoricoids

Organism: Mouse

Tissue: Adrenal Gland

Pathological State: Hypocholesterolemia

185
TIM‐4 increases the proportion of CD4+CD25+FOXP3+ regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL‐6 secretion

Z Wang, Z Xie, Y Mou, R Geng, C Chen, N Ke

Cancer Medicine (Wiley Online Library) China, 05 September 2024

Oncology

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

186
Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response

J An, R Kurilov, T Peccerella, F Bergmann, SS Mughal, L Zezlina, F Fortunato, G Beyer, J Mayerle, S Roth, J Hulkkonen, D Merz, S Ei, A Mehrabi, M Loos, MS Al-Saeedi, CW Michalski, MW Büchler, T Hackert, B Brors, SJ Pandol, P Bailey, JP Neoptolemos

Translational Oncology (Elsevier) Germany, Japan USA, 31 August 2024

Oncology

Key words: Pancreatic Cancer, Apoptosis, Autophagy, Molecular subtypes, GSK3-β, Histone deacetylases

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

187
A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single‐cell suspension

M Kandra, T Vanova, VA Jongen, J Pospíšil, J Novák, V Chochola, T Buryška, Z Prokop, Z Hodný, A Hampl, D Bohaciakova, J Jaros

Biotechnology Journal (Wiley) Czech Republic, Switzerland, 30 August 2024

Biotechnology

Key words: 3D cell culture, microfluidics, organoids, pluripotent stem cells, tissue engineering

Tissue: Organoid

188
MULTIMODAL IMAGING OF CELLULAR SENESCENCE–OXIDIZED LIPIDS AND ENZYMATIC ADAPTATIONS IN AGING SKIN AT THE SINGLE CELL LEVEL

C Kremslehner, MS Narzt, S Zoratto, M Sochorová, IM Nagelreiter, G Gendronneau, F Marcato, A Tessier, E Ponweiser, A Haschemi, M Marchetti-Deschmann, F Gruber

RedoXplore (RedoXplore) Austria, 29 August 2024

Dermatology

Organism: Human

Tissue: Skin

Pathological State: Aging

189
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in …

K Liao, J Chen, J Ma, CC Dong, CY Bi, YB Gao, YF Jiang, T Wang, HY Wei, L Hou, JQ Hu, JJ Wei, CY Zeng, YL Li, S Yan, H Xu, SH Liang, L Wang

Acta Pharmacologica Sinica (Nature) China, USA, 29 August 2024

Neuroimaging

Key words: translocator protein 18 kDa, TSPO, D2-LW223, neuroinflammation, PET, 18F

190
Tumor microenvironment biomarkers predicting pathological response to neoadjuvant chemoimmunotherapy in locally advanced esophageal squamous cell carcinoma: post-hoc analysis of a single center, phase 2 study

T Feng, Q Li, R Zhu, C Yu, L Xu, L Ying, C Wang, W Xu, J Wang, J Zhu, M Huang, C Xu, J Jin, X Zhang, T Lu, Y Yang, C Zhu, Q Chen, D Su

Journal for ImmunoTherapy of Cancer (jitc.bmj.com) China, 28 August 2024

Oncology

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

191
Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer

L Chibaya, KD DeMarco, CF Lusi, GI Kane, ML Brassil, CN Parikh, KC Murphy, SR Chowdhury, J Li, B Ma, TE Naylor, J Cerrutti, H Mori, M Diaz-Infante, J Peura, JR Pitarresi, LJ Zhu, KA Fitzgerald, PU Atukorale, M Ruscetti

Science Translational Medicine (Science) USA, 28 August 2024

Oncology

192
The PARP inhibitor rucaparib blocks SARS‐CoV‐2 virus binding to cells and the immune reaction in models of COVID‐19

M Madai, A Kuczmog, G Batta, O Mózner, D Vaskó, E Hirsch, P Bohus, G Méhes, J Tőzsér, NJ Curtin, Z Helyes, A Tóth, NC Hoch, F Jakab, GM Keserű, JE Pongrácz, P Bai

British Journal of Pharmacology (Wiley Online Library) Hungary, Brazil, UK, 27 August 2024

Virology

Organism: Human

Pathological State: Viral Infection

Cell Line: A549

193
Fibronectin type III domain containing 4 alleviates myocardial ischemia/reperfusion injury via the Nrf2-dependent antioxidant pathway

X Xu, L Peng, Y Xia, Y Guo, T Qi, C Li, F Ding, H Zhao, X Zhao, Q Liu, X Han, L Xia, Y He, W Li, R Liu, X Xu, C Hai, W Yan, L Tao

Free Radical Biology and Medicine (Elsevier) China, 26 August 2024

Cardiology

Key words: Myocardial ischemia/reperfusion injury, Fibronectin type III domain containing 4, Cardiomyocyte apoptosis, Oxidative stress, Nrf2

Cell Line: iPSC-CMs

194
Hepatic and metabolic outcomes induced by sub-chronic exposure to polystyrene microplastics in mice

SH Lee, TA Lin, YH Yan, CC Chien, TJ Cheng

Archives of Toxicology (Springer) Taiwan, 25 August 2024

Toxicology

Key words: Microplastics, Sub-chronic exposure, Hepatotoxicity, Mouse model, Metabolic dysfunction, Non-alcoholic steatohepatitis

Organism: Mouse

Tissue: Liver

195
Identification of a novel alternative splicing isoform of the Hippo kinase STK3/MST2 with impaired kinase and cell growth suppressing activities

AM Rodrigues, APZ Petisco Fiore, GDA Guardia, R Tomasin, AA Reis Teixeira, RJ Giordano, D Schechtman, M Pagano, PAF Galante, A Bruni-Cardoso

Oncogene (Nature) Brazil, USA, 22 August 2024

Biochemistry, Cell Biology

Cell Line: T4–2 cells, HEK293FT cells

196
Tolerance and toxicity assessment of a novel methionine source, dipeptide Met-Met on common carp Cyprinus carpio

Z Yin, B Shi, X Liang, H Wang, J Wang, J He, M Xue

Aquaculture (Elsevier) China, 22 August 2024

Toxicology

Key words: Met-Met, Safety assessment, Overdose, Metabolites, Common carp

Organism: Common Carp

Tissue: Small Intestine

197
Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction …

Z Chu, M Zhu, Y Luo, Y Hu, X Feng, J Shen, H Wang, M Sunagawa, Y Liu

Journal of Pharmaceutical Analysis (Elsevier) China, Japan, 22 August 2024

Oncology

Key words: Traditional Chinese medicine, Polypyrimidine tract binding protein 1, Alpha actinin-4, Gastric Cancer, Actin skeleton remodelling

Organism: Mouse

Tissue: Stomach

Pathological State: Cancer

198
Extracellular vesicles of the probiotic E. coli O83 activate innate immunity and prevent allergy in mice

Z Chu, M Zhu, Y Luo, Y Hu, X Feng, J Shen, H Wang, M Sunagawa, Y Liu

Journal of Pharmaceutical Analysis (Elsevier) China, Japan, 22 August 2024

Oncology

Key words: Traditional Chinese medicine, Polypyrimidine tract binding protein 1, Alpha actinin-4, Gastric Cancer, Actin skeleton remodelling

Organism: Mouse

Tissue: Stomach

Pathological State: Cancer

199
Integrated bioinformatics analysis and experimental validation reveal the relationship between ALOX5AP and the prognosis and immune microenvironment in …

P Song, H Deng, Y Liu, M Zhang

BMC Medical Genomics (Springer) China, 21 August 2024

Oncology

Key words: Glioma, ALOX5AP, Multiplex Immunoflorescence, Tumor-associated macrophage, Prognosis

Organism: Human

Pathological State: Cancer

Cell Line: ndGBM_02 

200
TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in …

H Zhuo, J Hou, Z Hong, S Yu, H Peng, L Zhang, WW Xie, X Hong

Cell Death & Disease (Nature) China, 21 August 2024

Oncology

Key words: Cancer therapy, Predictive markers

Organism: Mouse

Tissue: Stomach

Pathological State: Cancer

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