Customer Publications (A total of 3186 papers published)
Caspase Inhibition Restores Collagen I α1 and Fibronectin Release in Cigarette Smoke Extract-Exposed Human Lung Fibroblasts
American Journal of Physiology Lung Cellular and Molecular Physiology (American Physiological Society) Italy, The Netherlands, 06 February 2025
Pulmonology
Key words: caspase; cigarette smoke extract; extracellular matrix; gasdermin E; human lung fibroblasts [more]
Organism: Human
Tissue: Lung
Pathological State: Smoking
Morphometry of the Scapular Notch and Its Clinical Implication in Suprascapular Nerve Entrapment
Diagnostics (MDPI) Chile, Colombia, 02 February 2025
Osteology
Key words: advanced anatomy; morphometry; scapula; scapular notch; neuropathy; suprascapular nerve [more]
Organism: Human
Tissue: Nerve
Pathological State: Entrapment Neuropathy
Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3
Cell Reports (Cell) China, 31 January 2025
Oncology
Key words: hepatocellular carcinoma, post-translational modification, histone methylation [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
VPS18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis–infected macrophages
Science Advances (Science) USA, The Netherlands, 31 January 2025
Bacteriology
Organism: Human
Pathological State: Bacterial Infection
Cell Line: THP-1
Infiltration and subtype analysis of CD3+ CD20+ T cells in lung cancer
BMC cancer (Springer) China, 30 January 2025
Oncology
Key words: Lung cancer, Tertiary lymphoid structures, CD3+CD20+T cell, Double negative T cell [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Alda‑1 restores ALDH2‑mediated alcohol metabolism to inhibit the NF‑κB/VEGFC axis in head and neck cancer
International Journal of Molecular Medicine (Spandidos Publications) Taiwan, 30 January 2025
Oncology
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma
Cell Discovery (Nature) China, 28 January 2025
Oncology
Key words: Cancer microenvironment, Tumour immunology [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
RNA-seq reveals Lysyl oxidase as a potential biomarker of glomerular function in diabetic nephropathy in rats
Gene (Elsevier) China, 27 January 2025
Nephrology
Key words: Diabetic nephropathy, Bioinformatic analysis, Lysyl oxidase, RNA-seq [more]
Organism: Rat
Tissue: Kidney
Pathological State: Diabetes
Effect of in vivo reprogramming of astrocytes combined with exercise training on neurorepair in rats with spinal cord injury
Animal Models and Exerimental Medicine (Wiley Online Library) China, 23 January 2025
Neuroscience
Key words: astrocyte, exercise training, functional recovery, reprogramming, spinal cord injury [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury
PLOS One (PLOS One) China, 22 January 2025
Neuroscience
Key words: Soleus muscles, Spinal cod injury, Skeletal muscles, Spinal cord, Body weight, Exercise therapy, Muscle fibres, Muscle proteins [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
SUMO-Specific Peptidase 5 Promotes Oesophageal Squamous Cell Carcinoma Growth through the NF-κB-SLC1A3 Axis
Frontiers in Bioscience … (IMR Press) China, 22 January 2025
Oncology
Key words: SENP5, oesophageal squamous cell carcinoma, SLC1A3, NF-κB [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
HVEM as a Tumor-Intrinsic Regulator in Non-Small Cell Lung Cancer: Suppression of Metastasis via Glycolysis Inhibition and Modulation of Macrophage Polarization
Pharmacological Research (Elsevier) China, 18 January 2025
Oncology
Key words: NSCLC, HVEM, MPRIP, Glycolysis pathway, Macrophages, Tumor metastasis [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Understanding phage BX-1 resistance in Vibrio alginolyticus AP-1 and the role of quorum-sensing regulation
Microbiology Spectrum (ASM Journals) China, 14 January 2025
Bacteriology
Organism: Bacteria
Pathological State: Viral infection
Cell Line: AP-1, ΔbcsE AP-1, Δbcs AP-1
Exploring the molecular mechanisms of tirzepatide in alleviating metabolic dysfunction-associated fatty liver in mice through integration of metabolomics, lipidomics, and proteomics
Lipids in Health and Disease (Springer) China, 10 January 2025
Hepathology
Key words: Metabolic dysfunction-associated fatty liver disease, Tirzepatide, Metabolomics, Lipidomics, Proteomics [more]
Organism: Mouse
Tissue: Liver
Pathological State: Fatty Liver Disease
Serum Exosomes miR-122-5P Induces Hepatic and Renal Injury in Septic Rats by Regulating TAK1/SIRT1 Pathway
Infection and Drug Resistance (Taylor & Francis) China, 10 January 2025
Nephrology,Hepathology
Key words: sepsis, exosomem, iR-122-5p, NF-κB signaling pathway, sepsis-related liver and kidney injury [more]
Organism: Rat
Tissue: Liver, Kidney
Pathological State: Sepsis
SRC enhanced cisplatin resistance in bladder cancer by reprogramming glycolysis and pentose phosphate pathway
Communications Biology (Nature) China, USA, 10 January 2025
Oncology
Key words: Bladder cancer, Cancer metabolism, Cancer therapeutic resistance, Glycobiology [more]
Organism: Human
Tissue: Bladder
Pathological State: Cancer
A novel nanocarrier based on natural polyphenols enhancing gemcitabine sensitization ability for improved pancreatic cancer therapy efficiency
Materials Today Bio (Elsevier) China, 08 January 2025
Oncology
Key words: Nanocarrier, 1,2,3,4,6-Pentagalloyl glucose, Gemcitabine, Sensitizing chemotherapy, Pancreatic cancer [more]
Organism: Mouse
Tissue: Pancreas
Pathological State: Cancer
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring
Ecotoxicology and Enviormental Safety (Elsevier) China, 03 January 2025
Reproductive Medicine
Key words: Polystyrene nanoplastics, Primordial follicles, Maternal exposure, Reproductive damage, Progeny [more]
Organism: Mouse
Tissue: Ovaries
Pathological State: Nanoplastic
Lung cancer–intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg cell–dependent CD8+ T-cell exclusion
Cancer Immunology Research (AACR) USA, 02 January 2025
Oncology
Key words: Tumor microenvironment, T cell exclusion, tumor vasculature, checkpoint blockade therapy, non-small cell lung cancer, tumor-intrinsic SOX2 signaling pathway, regulatory T cells [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment
Ecotoxicology and Enviormental Safety (Elsevier) China, 02 January 2025
Pulmonology
Organism: Mouse
Tissue: Lung
Pathological State: Fibrosis
FoxC1 activates Notch3 signaling to promote the inflammatory phenotype of keloid fibroblasts and aggravates keloid
Experimental Cell Research (Elsevier) China, 01 January 2025
Dermatology
Key words: Keloid, FoxC1, Notch3, Fibroblasts [more]
Organism: Mouse, Human
Tissue: Skin
Pathological State: Keloid
Insights in glial cell pathology and multiple sclerosis: from an-omics and hiPSC perspective
(University of Groningen) The Netherlands, 01 January 2025
Neuroscience
Organism: Human
Tissue: Brain
Pathological State: Multiple Sclerosis
Long Afterglow Hybrid Nanoplatform for Integrated NIR-Ⅱ Imaging Diagnosis and Triple-synergistic Treatment of Choroidal Melanoma
Talanta (Elsevier) China, 30 December 2024
Oncology
Key words: Long afterglow material, NIR-II imaging, Photothermal and photodynamic therapy, Sustained-release chemotherapy drugs, Choroidal melanoma [more]
Organism: Mouse
Tissue: Eye
Pathological State: Cancer
Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNVIP neurons
Communications Biology (Nature) China, 28 December 2024
Neuroscience
Key words: Circadian rhythms and sleep, Molecular medicine [more]
Organism: Mouse
Tissue: Brain
Pathological State: Chemical Exposure
Association of PD-1 + Treg/PD-1 + CD8 ratio and tertiary lymphoid structures with prognosis and response in advanced gastric cancer patients receiving preoperative treatment
Journal of Translational Medicine (BMC) China, 27 December 2024
Oncology
Key words: Gastric cancer (GC), PD-1 + Treg/PD-1 + CD8 ratio, Tertiary lymphoid structure (TLS), Neoadjuvant therapy, Conversion therapy [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
Hyperactive delta isoform of PI3Kinase enables long distance regeneration of adult rat corticospinal tract
Molecular Therapy (Cell) Czech Republic, UK, Slovakia, The Netherlands, 27 December 2024
Neuroscience
Key words: pinal cord, axon regeneration, signalling, PI3K, pS6, skilled paw reaching, electrophysiology, c-Fos [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord injury
Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK-mediated mitochondria protection in early diabetic retinopathy
Pharmacological Research (Elsevier) China, 26 December 2024
Pharmacology
Key words: Ginsenoside Ro, Endothelial cell, Epac1/APMK pathway, Mitochondria damage, Diabetic retinopathy [more]
Organism: Mouse
Tissue: Eye
Pathological State: Diabetes
Exploring the Effects of Imidacloprid on Liver Health and the Microbiome in Rats: A Comprehensive Study
Microorganisms (MDPI) Saudi Arabia, 25 December 2024
Hepathology
Key words: imidacloprid; liver function; gut microbiome; microbial diversity; environmental and human health; dysbiosis [more]
Organism: Rat
Tissue: Liver
Pathological State: Inflammation
Fusobacterium sphaericum sp. nov., isolated from a human colon tumor adheres to colonic epithelial cells and induces IL-8 secretion
Gut Microbes (Taylor & Francis) USA, Germany, Italy, 25 December 2024
Bacteriology
Key words: Fusobacterium, novel species, pangenome, comparative genomics, intestinal microbiota, colorectal cancer [more]
Organism: Bacteria
Cell Line: Fusobacterium Sphaericum
Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding Normal Cells
Cancer Medicine (Wiley Online Library) China, 23 December 2024
Oncology
Key words: glioblastoma, inhibitor of PRMT5/MTA, MTAP-deleted, synthetic lethal hypothesis [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Astragalus Polysaccharide Mitigates Rhabdomyolysis-Induced Acute Kidney Injury via Inhibition of M1 Macrophage Polarization and the cGAS-STING Pathway
Journal of Inflammation Research (Taylor & Francis) China, 22 December 2024
Nephrology
Key words: astragalus polysaccharide, macrophages, rhabdomyolysis-induced acute kidney injury, cGAS-STING pathway [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Acute Kidney Injury
Adequate post-ischemic reperfusion of the mouse brain requires endothelial NFAT5
Acta Neuropathologica Communications (Springer) Germany, 22 December 2024
Neuroscience
Key words: NFAT5, KCNJ2, Endothelial cells, Ischemic stroke, Reperfusion [more]
Organism: Mouse
Tissue: Brain
Pathological State: Ischemia
Impact of c-JUN deficiency on thalamus development in mice and human neural models
Cell & Bioscience (BMC) China, 20 December 2024
Neuroscience
Key words: c-JUN, AP-1, NPC, Cerebral organoids, Thalamus organoids, Neural development [more]
Organism: Mouse
Tissue: Brain
Pathological State: Protein Injection
Perforated imprinting on high moisture meat analogue confers long range mechanical anisotropy resembling meat cuts
npj Science of Food (Nature) Singapore, 20 December 2024
Foodscience
Key words: Biomaterials – proteins, Technology
Targeting the Calcium-Sensing Receptor in Chemically Induced Medium-Grade Colitis in Female BALB/C Mice
Nutrients (MDPI) Austria, Germany, UK, 18 December 2024
Neuroscience, Gastroenterology
Key words: calcium-sensing receptor; calcium; inflammatory bowel disease; colitis; NPS 2143 [more]
Organism: Mouse
Tissue: Intestine
Pathological State: Colitis
Plasma CircCYP24A1 as a Novel Biomarker of Esophageal Squamous Cell Carcinoma
Technology in Cancer Research & Treatment (Sage Journals) China, 18 December 2024
Oncology
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Metabolic shifts in lipid utilization and reciprocal interactions within the lung metastatic niche of triple-negative breast cancer revealed by spatial multi-omics
Cell Death & Disease (Nature) Taiwan, 18 December 2024
Oncology
Key words: Cancer metabolism, Transcriptomics [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Induced pluripotent stem cells (iPSCs) as a cellular therapy for post-traumatic osteoarthritis in a murine model
(University of Calgary) Canada, 18 December 2024
Osteology
Organism: Mouse
Tissue: Knee
Pathological State: Arthritis
High-intensity interval training or lactate administration combined with aerobic training enhances visceral fat loss while promoting VMH neuroplasticity in female rats
Lipids in Health and Disease (BMC) China, 18 December 2024
Sport Science
Key words: High-intensity interval training, Lactate, Visceral fat, VMH, LFPs [more]
Organism: Rat
Tissue: Brain
Human decellularized adipose matrix derived hydrogel facilitates human umbilical cord-derived mesenchymal stem cells delivery with clinical translational potential value in accelerating wound healing
Colloids and Surfaces A: Physicochemical and Engineering Aspects (Elsevier) China, 17 December 2024
Regenerative Medicine
Key words: Adipose tissue, Decellularized matrix hydrogel, Human umbilical cord-derived mesenchymal, stem cells, Stem cell therapy, Wound healing [more]
Organism: Pig
Tissue: Skin
Pathological State: Wound
Single-cell RNA sequencing of chronic idiopathic erythroderma defines disease-specific markers
Journal of Allergy and Clinical Immunology (Elsevier) USA, Austria, 16 December 2024
Dermatology
Organism: Human
Tissue: Skin
Pathological State: Inflammation
Atlas of Normal Articular Cartilage: Structural and Functional Comparison Across Species
(University of Calgary) Canada, 16 December 2024
Osteology
Organism: Mouse, Rat, Chicken
Tissue: Bone
Pathological State: Arthritis
Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma
mSystems (ASM Journals) China, 11 December 2024
Oncology
Organism: Human
Tissue: Brain
Pathological State: Cancer
Impacts of Gestational F-53B Exposure on Fetal Neurodevelopment: Insights from Placental and Thyroid Hormone Disruption
Environment & Health (ACS Publications) China, 11 December 2024
Reproductive Medicine
Key words: F-53B, thyroid hormone, placental development, neurotoxicity, DNA methylation [more]
Organism: Mouse
Tissue: Brain
Pathological State: Chemical Exposure
Colchicine Alleviates Interstitial Lung Disease in an Experimental Autoimmune Myositis Murine Model by Inhibiting the Formation of Neutrophil Extracellular Traps
Inflammation (Springer) China, 11 December 2024
Pulmonology
Key words: Interstitial lung disease, Experimental autoimmune myositis, Colchicine, Neutrophil extracellular traps, Pyroptosis [more]
Organism: Mouse, Rat
Tissue: Lung
Pathological State: Interstitial lung disease
Developmental and adult striatal patterning of nociceptin ligand marks striosomal population with direct dopamine projections
Journal of Comparative Neurology (Wiley Online Library) USA, 10 December 2024
Neuroscience
Organism: Mouse
Tissue: Brain
Novel biomarkers: the RUNX family as prognostic predictors in colorectal cancer
Frontiers in Immunology (Frontiers Media SA) China, 09 December 2024
Oncology
Key words: RUNX, tumor-infiltrating CD8+T cells, multi-color immunohistochemical staining, colorectal cancer, prognosis [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Protective effect of trehalose on sperm chromatin condensation failure and semen quality decline in BDE-209-exposed mice
Food and Chemical Toxicology (Elsevier) China, 08 December 2024
Reproductive Medicine
Key words: Deca-bromodiphenyl ether (BDE-209), Histone-to-protamine exchange, Autophagy, Semen parameters, AMPK [more]
Organism: Mouse
Tissue: Testis
Pathological State: Chemical Exposure
Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia
Cell reports (Cell) USA, 07 December 2024
Pulmonology
Key words: regulatory T cells, Tregs, vimentin, distal pole complex, IL-18R, AREG, epidermal growth factor receptor, viral pneumonia, lung injury, lung repair [more]
Organism: Mouse
Tissue: Lung
Pathological State: Pneumonia
Modulation of Biomaterial‐Associated Fibrosis by Means of Combined Physicochemical Material Properties
Advanced Science (Wiley Online Library) The Netherlands, 06 December 2024
Transplantation Medicine
Organism: Human
Pathological State: Medical Implant
Cell Line: C-12302
Programming tissue-sensing T cells that deliver therapies to the brain
Science (Science) USA, 06 December 2024
Neuroscience
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
SGLT2 inhibitor downregulates ANGPTL4 to mitigate pathological aging of cardiomyocytes induced by type 2 diabetes
Cardiovascular Diabetology (BMC) China, 04 December 2024
Cardiology
Key words: SGLT2i, Diabetic cardiomyopathy, Cellular senescence, ANGPTL4, FOXO1 [more]
Organism: Mouse
Tissue: Heart
Pathological State: Diabetes
Expression of Neurotrophins and Its Receptors During Fetal Development in the Human Cochlea
International Journal of Molecular Sciences (MDPI) Austria, Japan, Sweden, UK, 03 December 2024
Reproductive Medicine
Key words: human inner ear, BDNF, NT-3, NT-4, Trk receptor, p75, neurotrophins, development, hearing [more]
Organism: Human
Tissue: Ear
Distinct structural and functional connectivity of genetically segregated thalamoreticular subnetworks
Cell Reports (Cell) USA, 03 December 2024
Neuroscience
Key words: thalamic reticular nucleus, TRN, thalamocortical circuits, TRN subnetwork synaptic connectivity, electrophysiology, EEG, neuropsychiatric disorders, neurodevelopmental disorders [more]
Organism: Mouse
Tissue: Brain
Pathological State: Viral Infection
The inhibition of PINK1/Drp1-mediated mitophagy by hyperglycemia leads to impaired osteoblastogenesis in diabetes
iScience (Cell) China, 02 December 2024
Osteology
Organism: Mouse
Tissue: Bone
Pathological State: Diabetes
Anti-BAFF-Behandlung verringert Transplantatfibrose und DKK3-Expression im Modell der Nonadhärenz bei experimenteller Nierentransplantation in der Ratte
(Universität Regensburg) Germany, 02 December 2024
Nephrology
Organism: Rat
Tissue: Kidney
Pathological State: Organ Transplantation
398 A crosstalk of CD8+ resident memory T cells and skin Dendritic cells protects organ transplant receivers from skin cancer development
Journal of Investigative Dermatology (Elsevier) Austria, 01 December 2024
Dermatology, Oncology
Organism: Human
Tissue: Skin
Pathological State: Cancer
MORPHOLOGICAL CHANGES IN LEYDIG TM3 CELLS INDUCED BY NEONICOTINOID ACETAMIPRID
Journal of Microbiology Biotechnology and Food Sciences (Faculty of Biotechnology and Food Sciences) Slovakia, 01 December 2024
Reproductive Medicine
Key words: acetamiprid, Leydig cells, 3D-cultivation, morphology [more]
Organism: Mouse
Pathological State: Chemical Exposure
Cell Line: Leydig TM3
GsMTx4 Combined with Exercise Exerts Neuroprotective Effects by Regulating Neuronal Autophagy in Rats with Spinal Cord Injury
Neurochemical Research (Springer) China, 29 November 2024
Neuroscience
Key words: Spinal cord injury, GsMTx4, Exercise, Autophagy, Nerve repair
Enhanced and sustained biodistribution of HIV-1 neutralizing antibody VRC01LS in human genital and rectal mucosa
Nature Communications (Nature) USA, South Africa, 28 November 2024
Virology
Key words: HIV infections, Immunization, Mucosal immunology, Translational immunology [more]
Organism: Human
Tissue: Rectum
Pathological State: Viral Infection
Carbonic anhydrase 2 facilitates sorafenib resistance by counteracting MCT4-mediated intracellular pH dysregulation in HCC
Cell Reports (Cell) China, 27 November 2024
Oncology
Key words: Sorafenib resistance, Hepatocellular carcinoma, HCC organoids, Intracellular pH homeostasis, CA2 [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
The Distinct Biological Effects of 6-Hydroxy-L-Nicotine in Representative Cancer Cell Lines
Molecules (MDPI) Romania, 26 November 2024
Oncology
Key words: 6-hydroxy-L-nicotine, nicotine, nicotinic receptors, cancer [more]
Organism: Human
Pathological State: Cancer
Cell Line: 16HBE14o
SIRT1-dependent regulation of mitochondrial metabolism participates in miR-30a-5p-mediated cardiac remodeling post-myocardial infarction
Journal of Clinical and Experimental Hepatology (Elsevier) Germany, The Netherlands, 25 November 2024
Oncology
Key words: cholangiocellular carcinoma, immune cells, body composition, oncological outcome [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
Identification of prognostic tumor microenvironment in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy combined with lenvatinib and PD-1 inhibitors
International Immunopharmacology (Elsevier) China, 23 November 2024
Oncology
Key words: Tumor microenvironment, HCC, HAIC, Lenvatinib, Programmed cell death protein-1 [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
Weekly Intraperitoneal Injection of Tamoxifen in an Inducible in vivo Model of Junctional Epidermolysis Bullosa Generates Early and Advanced Disease Phenotypes
JID Innovations (Elsevier) UK, Germany, 22 November 2024
Dermatology
Key words: Junctional EB, Laminin, skin inflammation, inducible transgenic model [more]
Organism: Mouse
Tissue: Skin
Pathological State: Junctional Epidermolysis Bullosa
Multimodal single cell-resolved spatial proteomics reveal pancreatic tumor heterogeneity
Nature Communications (Nature) China, 21 November 2024
Oncology
Key words: Cancer microenvironment, Imaging, Proteomic analysis, Proteomics [more]
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
Early and late place cells during postnatal development of the hippocampus
Nature Communications (Nature) China, 21 November 2024
Neuroscience
Key words: Hippocampus, Spatial memory [more]
Organism: Rat
Tissue: Brain
Pathological State: Viral Infection
Amino Acids Fueling Fibroblast‐Like Synoviocyte Activation and Arthritis By Regulating Chemokine Expression and Leukocyte Migration
Arthritis & Rheumatology (Wiley Online Library) Austria, France, Germany, 20 November 2024
Osteology
Organism: Human
Tissue: Synovial Joint
Pathological State: Arthritis
Uncovering the predictive and immunomodulatory potential of transient receptor potential melastatin family-related CCNE1 in pan-cancer
Molecular Cancer (Springer) China, 18 November 2024
Oncology
Key words: CCNE1, Cancer immunotherapy, TRPM family, Macrophage, Tumor microenvironment [more]
Organism: Human
Tissue: Liver, Skin, Lung, Kidney, Stomach,
Pathological State: Cancer
Effects of particulate air pollution on BPDE-DNA adducts, telomere length, and mitochondrial DNA copy number in human exhaled breath condensate and BEAS-2B cells
International Journal of Hygiene and Eviormental Health (Elsevier) Thailand, 18 November 2024
Enviormental Biology
Key words: Particulate matter, Polycyclic aromatic hydrocarbon, Exhaled breath condensate, BPDE-DNA adduct, Telomere length, Mitochondrial DNA copy number [more]
Organism: Human
Pathological State: Chemical Exposure
Cell Line: BEAS-2B
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
Nature Immunology (Nature) USA, UK, Austria, Sweden, China, 18 November 2024
Oncology
Key words: Sequencing, Tumour immunology [more]
Organism: Human
Tissue: Skin
Pathological State: Cancer
YAP enhances mitochondrial OXPHOS in tumor-infiltrating Treg through upregulating Lars2 on stiff matrix
Journal for ImmunoTherapy of Cancer (BMJ) China, 17 November 2024
Oncology
Key words: Solid tumor, T regulatory cell - Treg, Extracellular Matrix, Mitochondria [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
Body composition in cholangiocarcinoma affects immune cell populations in the tumor and normal liver parenchyma
Free Radical Biology and Medicine (Elsevier) China, 16 November 2024
Cardiology
Key words: miR-30a-5p, Myocardial infarction, SIRT1, Mitochondrial metabolism [more]
Organism: Mouse
Tissue: Heart
Pathological State: Mycardial Infarction
Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity
Science Immunology (Science) China, 15 November 2024
Immunology
Organism: Human
Tissue: Liver
Pathological State: Cancer
Fas Apoptosis Inhibitory Molecule 2 Inhibits Pathological Cardiac Hypertrophy by Regulating the MAPK Signaling Pathway
Journal of the Ameriacan Heart Association (AHA Journals) China, 15 November 2024
Cardiology
Organism: Rat
Tissue: Heart
Pathological State: Hyperthropy
Integrated proteomics and scRNA-seq analyses of ovarian cancer reveal molecular subtype-associated cell landscapes and immunotherapy targets
British Journal of Cancer (Nature) China, 15 November 2024
Oncology
Key words: Cancer immunotherapy, Ovarian cancer, Proteome informatics, Target identification, Targeted therapies [more]
Organism: Human
Tissue: Ovaries
Pathological State: Cancer
BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice With Loss of the Polarity Protein Par3
Immunity & Ageing (BMC) China, 14 November 2024
Neuroscience
Key words: Aging-associated cognitive decline, Cognitive heterogeneity, Microglial activation, Th17/Treg cells, Inflammation [more]
Organism: Rat
Tissue: Brain
Pathological State: Inflammation
A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer
(Queensland University of Technology) Australia, 14 November 2024
Cardiology
Key words: Heart regeneration, cardiac maturation, cardiomyocyte proliferation, ectothermy, endothermy, energy, metabolism, human cardiac organoids [more]
Organism: Human
Tissue: Heart
Development and evaluation of an autism pig model
Lab Animal (Nature) China, 12 November 2024
Neuroscience
Key words: Autism spectrum disorders [more]
Organism: Pig
Tissue: Brain
Pathological State: Autism
BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti-PD-1/PD-L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity
Cancer Cell International (Springer) China, 07 November 2024
Oncology
Key words: MGAT5, Colorectal Cancer, Metastasis, ZO-1, EMT [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
High frequency of point mutations in the nitroreductase 4 and 6 genes of Trichomonas vaginalis associated with metronidazole resistance
Folia Parasitologica (Czech Academy of Sciences) Chile, 07 November 2024
Parasitology
Key words: genital infection, trichomoniasis, refractory treatment, protein polymorphism, dysfunctional enzyme, clinical samples [more]
Organism: Human
Tissue: Vagina
Pathological State: Infection
In vitro and in vivo investigation of the inhibitory effects of Sinoporphyrin sodium-mediated Sonodynamic therapy on human oral squamous cell carcinoma
Nature Communications (Nature) Australia, Austria, Spain, Finland, UK, Sweden, USA, France, Denmark, Germany, Belgium, 06 November 2024
Oncology
Key words: Cancer genetics, Genetic association study, Prostate cancer, Proteases, Tumour biomarkers [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
Heterogeneous Patterns of Endothelial NF-κB p65 and MAPK c-Jun Activation, Adhesion Molecule Expression, and Leukocyte Recruitment in Lung Microvasculature of Mice with Sepsis
International Journal of Biological Macromolecules (Elsevier) Taiwan, 04 November 2024
Osteology
Key words: HS-GAG, Heparinase III enzyme, BM-MSC, Intrinsic TGF-β signaling, Chondrogenesis, Self-renewal activity, Immunosuppressive potential [more]
Organism: Mouse
Tissue: Bone
Pathological State: Arthritis
Versatility of fluorescent nanodiamonds as free radical quantum sensors: from arthritis and metastasis to potential applications in heart diseases
Journal of Photochemistry & Photobiology (Elsevier) China, 04 November 2024
Oncology
Key words: Autophagy ,Human oral squamous cell carcinoma, Mitochondrial apoptosis, Sinoporphyrin sodium, Sonodynamic therapy [more]
Organism: Human
Pathological State: Cancer
Cell Line: SCC- 154
TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in gastric cancer
Biomaterials (Elsevier) China, 03 November 2024
Neuroscience
Key words: Umbilical cord-derived mesenchymal stem cells, Biomimetic microniche, Advantageous properties, Acute brain inflammation, Neuroinflammation, Microglia [more]
Organism: Mouse
Tissue: Brain
Pathological State: Inflammation
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke
Cardiovascular Diabetology (Springer) China, 02 November 2024
Cardiology
Key words: Diabetic cardiomyopathy, Ferroptosis, FGF21, Ferritin, ATF4, Type 2 diabetes mellitus [more]
Organism: Mouse
Tissue: Heart
Pathological State: Diabetes
UC-MSCs based on biomimetic microniche exert excellent regulatory effects on acute brain inflammation through advantageous properties
International Journal of Biological Macromolecules (Elsevier) China, 02 November 2024
Reproductive Medicine
Key words: Di-(2-ethylhexyl)phthalate, Lycium Barbarum polysaccharide, Sertoli cells, Ferroptosis, NRF2/SLC7A11/GPX4 pathway [more]
Organism: Mouse
Tissue: Testis
Pathological State: Ferroptosis
Rational development of fingolimod nano-embedded microparticles as nose-to-brain neuroprotective therapy for ischemic stroke
Chinese Journal of Tissue Engineering Research (CJTER) China, 02 November 2024
Pharmacology
Key words: myofascial pain syndrome, myofascial trigger points, stagnant moving needle, central analgesia, brain-derived neurotrophic factor, periaqueductal gray [more]
Organism: Rat
Tissue: Brain
Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway
Heliyon (Cell) China, 01 November 2024
Osteology
Key words: Guilu Erxian glue, Chondrocyte, Apoptosis, Knee osteoarthritis, ATF6/GRP78/CHOP signaling pathway [more]
Organism: Rat
Pathological State: Arthritis
Cell Line: Chondrocytes
Dual targeting macrophages and microglia is a therapeutic vulnerability in models of PTEN-deficient glioblastoma
Drug Delivery and Translational Research (Springer) China, 01 November 2024
Neuroscience
Key words: Nose-to-brain drug delivery, Neuroprotection, Ischemic stroke, Fingolimod, Nanoparticles, Particle engineering, Nasal powder [more]
Organism: Mouse
Tissue: Brain
Pathological State: Ischemia
High glucose-induced senescence contributes to tubular epithelial cell damage in diabetic nephropathy
Redox Biology (Elsevier) Taiwan, 31 October 2024
Reproductive Medicine
Key words: Uterine leiomyoma, NAMPT, NAD, Extracellular matrix [more]
Organism: Human
Tissue: Uterus
Pathological State: Uterine Leiomyoma
How the extra X chromosome impairs the development of male fetal germ cells
Nature (Nature) China, 30 October 2024
Reproductive Medicine
Key words: Disease Model, Embryonic germ cells [more]
Organism: Human
Tissue: Gonad
Pathological State: Klinefelter syndrome
Unravelling the role of the tumour microenvironment in follicular lymphoma progression through characterisation of the mutational, transcriptomic and spatial immune landscape
Communications Biology (Nature) China, 30 October 2024
Oncology
Key words: Molecular medicine, Non-small-cell lung cancer, Prognostic markers [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Spinal cord neural stem cells derived from human embryonic stem cells promote synapse regeneration and remyelination in spinal cord injury model rats
European Journal of Neuroscience (Wiley Online Library) China, 29 October 2024
Neuroscience
Key words: BAF45D, human spinal cord neural stem cells, MBP, spinal cord injury, synaptophysin [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Regulatory Roles of NAMPT and NAD+ Metabolism in Uterine Leiomyoma Progression: Implications for ECM Accumulation, Stemness, and Microenvironment
Frontiers in Aging Neuroscience (frontiers) China, 28 October 2024
Neuroscience
Key words: Huntington’s disease, R6/1, mutant huntingtin, retina, photoreceptor, ganglion cell, bipolar cell, optic nerve [more]
Organism: Mouse
Tissue: Brain
Pathological State: Huntington's Diseas
The m5C reader protein Ybx1 promotes axon growth by regulating local translation in axons
Development (The Company of Biologists) China, 28 October 2024
Neuroscience
Key words: m5Cmodification, Ybx1, Local translation in axons, Axon growth, DRG, Hippocampus [more]
Organism: Mouse
Tissue: Brain
Mechanism of Mitochondrial Kinetic Imbalance and Nrf2 Signaling Pathway-Mediated Oxidative Stress in Nickel and/or Chromium-Induced Kidney Injury in Mice
Oncology Letters (Spandidos Publications) Taiwan, 25 October 2024
Oncology
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: Cancer
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR
Molecular Cell (Cell) China, 25 October 2024
Biological Methods
Key words: circRNA, ZC3H14, exon-intron boundary, 3′ UTR, backsplicing, spermatogenesis, male infertility [more]
Organism: Mouse
Tissue: Testis
Pathological State: Viral Infection
Humanized In Vivo Bone Tissue Engineering: In Vitro Preculture Conditions Control the Structural, Cellular, and Matrix Composition of Humanized Bone Organs
Advanced Healthcare Materials (Wiley) Australia, 23 October 2024
Tissue Engineering, Osteology
Differential effects of alendronate on chondrocytes, cartilage matrix and subchondral bone structure in surgically induced osteoarthritis in mice
Scientific Reports (Nature) Germany, 23 October 2024
Rheumatology
Key words: DMM, Osteoarthritis, Bisphosphonate, Alendronate, VDIPEN, ADAMTS-5, Subchondral bone, Cartilage, Micro/nano-CT, Osteoclasts, Chondrocytes, NK1-R, MMP-13 [more]
Organism: Mouse
Tissue: Bone
BiTE-Secreting CAR-γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors
Scientific Reports (Nature) Germany, 23 October 2024
Osteology
Key words: ADAMTS-5, Alendronate, Bisphosphonate, Cartilage, Chondrocytes, DMM, MMP-13, Micro/nano-CT, NK1-R, Osteoarthritis, Osteoclasts, Subchondral bone, VDIPEN [more]
Organism: Mouse
Tissue: Bone
Pathological State: Arthritis
Ferroptosis-related gene signature for predicting prognosis and identifying potential therapeutic drug in EGFR wild-type lung adenocarcinoma
Advanced Healtcare Materials (Wiley Online Library) Australia, Germany, 23 October 2024
Osteology
Organism: Mouse
Tissue: Bone
Prophylactic use of probiotics as an adjunctive treatment for ischemic stroke via the gut-spleen-brain axis
Brain, Behavior, and Immunity (Elsevier) Taiwan, 22 October 2024
Neuroscience
Key words: Ischemic stroke, Probiotics, Gut-spleen-brain axis [more]
Organism: Mouse
Tissue: Small Intestine
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex
Cell Metabolism (Cell Press) China, 22 October 2024
Endocrinology, Oncology
Key words: obesity, breast cancer, adipocyte, glutathione, GSH, lysosomal integral membrane protein-2, SCARB2, ARF1, mammalian target of rapamycin complex 1, mTORC1 [more]
Organism: Mouse
Tissue: Breast
Pathological State: Cancer
Microbial and Transcriptomic Landscape Associated With Neutrophil Extracellular Traps in Perianal Fistulizing Crohn's Disease
Inflammatory Bowel Diseases (Oxford Academic) China, 22 October 2024
Gastroenterology, Immunology
Key words: Crohn’s disease, perianal fistula, microbiome, transcriptomics, neutrophil extracellular traps
IL-1β-induced epithelial cell and fibroblast transdifferentiation promotes neutrophil recruitment in chronic rhinosinusitis with nasal polyps
Nature Communications (Nature) China, USA, 22 October 2024
Immunology
Key words: Chronic inflammation, Gene regulation in immune cells, Interleukins, Mucosal immunology, Respiratory tract diseases [more]
Organism: Human
Tissue: Nasal mucosa
Therapeutic Effects of Engineered Exosomes from RAW264.7 Cells Overexpressing hsa-let-7i-5p against Sepsis in Mice—A Comparative Study with Human Placenta-Derived Mesenchymal Stem Cell Exosomes
Inflammatory Bowel Diseases (Oxford Academic) China, 22 October 2024
Gastroenterology
Key words: Crohn’s disease, perianal fistula, microbiome, transcriptomics, neutrophil extracellular traps [more]
Organism: Human
Tissue: Colon
Pathological State: Crohn's Diseas
N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation
Journal of Hazardous Materials (Elsevier) Taipei, 22 October 2024
Reproductive Medicine
Key words: Freshwater acidification, Energy mobilization, Energy allocation, Trade-off, Growth, Energy storage, Reproduction [more]
Organism: Medaka Fish
Tissue: Liver
Pathological State: Acidification
Eutopic and Ectopic Endometrial Interleukin-17 and Interleukin-17 Receptor Expression at the Endometrial—Myometrial Interface in Women with Adenomyosis: Possible Pathophysiology Implications
Nature Communications (Nature) China, 22 October 2024
Otolaryngology
Organism: Mouse
Tissue: Nose
Pathological State: Inflammation
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior
Purinergic Signalling (Springer) Brazil, Italy, 19 October 2024
Immunology, Oncology
Key words: Tumor-associated macrophages, P2Y2 receptor, Purinergic signaling, Chemoresistance, Invasion [more]
Cell Line: bone marrow-derived macrophages, human neuroblastoma cells
Optineurin regulates motor and learning behaviors by affecting dopaminergic neuron survival in mice
Experimental Neurology (Elsevier) China, 18 October 2024
Neuroscience
Key words: OPTN, Autophagy, Neurodegenerative diseases, Dopaminergic neurons [more]
Organism: Mouse
Tissue: Brain
Lavender improves sleep through olfactory perception and GABAergic neurons of the central amygdala
Journal of Ethnopharmacology (Elsevier) China, France, 18 October 2024
Neuroscience
Key words: Lavender, Aromatherapy, Sleep, Olfactory perception, The central amygdala, Insomnia [more]
Organism: Mouse
Tissue: Brain
Environmental acidification drives inter-organ energy mobilization to enhance reproductive performance in medaka (Oryzias latipes)
Journal of Hazardous Materials (Elsevier) Taiwan, 18 October 2024
Reproductive Biology
Key words: Freshwater acidification, Energy mobilization, Energy allocation, Trade-off, Growth, Energy storage, Reproduction [more]
Organism: Medaka Fish
Immune escape between endoplasmic reticulum stress-related cancer cells and exhausted CD8+T cells leads to neoadjuvant chemotherapy resistance in ovarian cancer
Cellular Signalling (Elsevier) China, 18 October 2024
Osteology
Key words: Osteoarthritis, Osteoblasts, FoxC1, Piezo1, YAP [more]
Organism: Human
Tissue: Bone
Pathological State: Arthritis
Proliferation und Organisation immigrierender Lymphozyten im Rahmen der Allograftabstoßung im experimentellen Nierentransplantationsmodell der Ratte
Journal of Ethnopharmacology (Elsevier) China, France, 18 October 2024
Neuroscience
Key words: Lavender, Aromatherapy, Sleep, Olfactory perception, The central amygdala, Insomnia [more]
Organism: Mouse
Tissue: Brain
Pathological State: Viral Infection
NPS-1034 Exerts Therapeutic Efficacy in Renal Cell Carcinoma Through Multiple Targets of MET, AXL, and TNFRSF1A Signaling in a Metastatic Model
Cells (MDPI) Taiwan, 17 October 2024
Oncology, Nephrology
Key words: kidney cancer; lung metastasis; tumor necrosis factor receptor 1; tyrosine kinase inhibitor; systemic treatment [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Eutopic and Ectopic Endometrial Interleukin-17 and Interleukin-17 Receptor Expression at the Endometrial—Myometrial Interface in Women with …
International Journal of Molecular Science (MDPI) Taiwan, 17 October 2024
Reproductive Biology
Key words: interleukin-17; adenomyosis; endometrial–myometrial interface; cytokine [more]
Organism: Human
Tissue: Endometrium
Pathological State: Adenomyosis
PTGES is involved in myofibroblast differentiation via HIF‐1α‐dependent glycolysis pathway
Journal of Cellular and Molecular Medicine (Wiley) Taiwan, 17 October 2024
Cell Biology
Key words: fibroblast, HIF-1α, metabolic pathway, myofibroblast, PTGES
Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction between PTBP1 and ACTN4
Cells (MDPI) Taiwan, 17 October 2024
Oncology
Key words: kidney cancer, lung metastasis, tumor necrosis factor receptor 1, tyrosine kinase inhibitor, systemic treatment [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Functional and Proteomic Dissection of the Contributions of CodY, SigB and the Hibernation Promoting Factor HPF to Interactions of Staphylococcus aureus USA300 with Human Lung Epithelial Cells
Journal of Cellular and Molecular Medicine (Wiley Online Library) Taiwan, 17 October 2024
Pulmonology
Organism: Rat
Tissue: Lung
Pathological State: Fibrosis
Single-cell transcriptomics reveals granzyme K-expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD
International Journal of Molecular Science (MDPI) Taiwan, 17 October 2024
Reproductive Medicine
Key words: interleukin-17, adenomyosis, endometrial–myometrial interface, cytokine [more]
Organism: Human
Tissue: Uterus
Pathological State: Adenomyosis
A single-dose circular RNA vaccine prevents Zika virus infection without enhancing dengue severity in mice
Nature Communications (Nature) China, 16 October 2024
Virology
Key words: RNA vaccines, Vaccines, Viral infection [more]
Organism: Mouse
Tissue: Brain
Pathological State: Zika virus infection
Investigating the role of various extracellular matrix in androgenetic alopecia: Insights from immunostaining and quantitative analysis–A pilot study
Nature Communications (Nature) China, 16 October 2024
Virology
Key words: RNA vaccines, Vaccines, Viral infection [more]
Organism: Mouse
Tissue: Brain
Pathological State: Viral Infection
Nivolumab plus anlotinib hydrochloride in advanced gastric adenocarcinoma and esophageal squamous cell carcinoma: the phase II OASIS trial
Nature Communications (Nature) China, 15 October 2024
Oncology
Key words: Cancer immunotherapy, Gastric cancer, Oesophageal cancer [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Quercetin Promotes Apoptosis of Gastric Cancer Cells through the EGFR‐ERK Signaling Pathway
Nature Communications (Nature) China, 15 October 2024
Oncology
Key words: Cancer immunotherapy,Gastric cancer, Oesophageal cancer [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
β-Mangostin Alleviates Renal Tubulointerstitial Fibrosis via the TGF-β1/JNK Signaling Pathway
Cells (MDPI) Taiwan, 14 October 2024
Nephrology, Molecular Biology
Key words: β-mangostin; renal tubulointerstitial fibrosis; EMT; TGF-β1; Smad2; JNK1/2 [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Renal Tubulointerstitial Fibrosis
CD24hiCD27+ Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer
Plant Communications (Cell) China, 14 October 2024
Botany
Key words: OsNLP3, OsCEP6.1, OsNF-YA8, grain weight, grain chalkiness, rice, Oryza sativa L. [more]
Organism: Rice
Tissue: Grain
Interleukin-32 producing CD8+ memory T cells and Tregs define the IDO1/PD-L1 niche in human cutaneous leishmaniasis skin lesions 2
Cells (MDPI) Taiwan, 14 October 2024
Nephrology
Key words: β-mangostin, renal tubulointerstitial fibrosis, EMT, TGF-β1, Smad2, JNK1/2 [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Kidney Diseas
Potential role of calcium sulfate/β-tricalcium phosphate/graphene oxide nanocomposite for bone graft application_mechanical and biological analyses
Journal of Orthopaedic Surgery and Research (josr-online.biomedcentral.com) Taiwan, 12 October 2024
Biomaterials
Key words: Calcium sulfate, Β-tricalcium phosphate, Graphene oxide, Mechanical strength, Degradation rate, Criticalsized calvarial defect model [more]
Organism: Rat
Tissue: Bone
Impact of cigarette smoke on inflammasome-dependent responses in human lung fibroblasts
Experimental Gerontology (Elsevier) China, 12 October 2024
Nephrology
Key words: Diabetic nephropathy, Epithelial-mesenchymal transition, Mitochondrial dysfunction, Senescence [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Diabetes
ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A Demethylation
Journal of Orthopaedic Surgery and Research (Springer) Taiwan, 12 October 2024
Osteology
Key words: Calcium sulfate, Β-tricalcium phosphate, Graphene oxide, Mechanical strength, Degradation rate, Critical-sized calvarial defect model [more]
Organism: Rat
Tissue: Bone
Pathological State: Calvarial Defect
Tumor immune microenvironment dynamics and outcomes of prognosis in non‐muscle‐invasive bladder cancer
Cancer Science (Wiley) Japan, 11 October 2024
Oncology
Key words: bladder cancer, FGFR3, microenvironment, PD-1, PD-L1 [more]
Organism: Human
Tissue: Bladder
Pathological State: Cancer
Forkhead box C1 promotes the pathology of osteoarthritis in subchondral bone osteoblasts via the Piezo1/YAP axis
Cellular Signalling (Elsevier) China, 11 October 2024
Osteology
Key words: Osteoarthritis, Osteoblasts, FoxC1, Piezo1, YAP [more]
Cell Line: Sclerotic subchondral osteoblasts
Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with …
Journal of Biomedical Science (Springer) Taiwan, Vietnam, 11 October 2024
Reproductive Biology, Stem Cell Research
Key words: Placenta mesenchymal stem cell, Estrogen receptor, Primary ovarian insufficiency, Ovarian circadian rhythm disorder, Angiogenin, Exosomal miRNA [more]
Organism: Mouse
Tissue: Ovaries
Characterisation of negative allosteric modulators of the calcium-sensing receptor, CaSR, for repurposing as a treatment for asthma
Cancer Science (Wiley Online Library) Japan, 11 October 2024
Oncology
Tissue: Bladder
Pathological State: Cancer
Cancer-Associated Fibroblasts in Gallbladder Cancer Modify the Migration and Invasion of Gallbladder Cancer Cells
Journal of Biomedical Science (Springer) Taiwan, Vietnam, 11 October 2024
Reproductive Medicine
Key words: Placenta mesenchymal stem cell, Estrogen receptor, Primary ovarian insufficiency, Ovarian circadian rhythm disorder, Angiogenin, Exosomal miRNA [more]
Organism: Mouse
Tissue: Ovaries
Pathological State: Primary Ovarian Insufficiency
Cytarabine chemotherapy induces meibomian gland dysfunction
The Ocular Surface (Elsevier) China, 10 October 2024
Oncology, Ophthalmology
Key words: Cytarabine, Meibomian gland dysfunction, PPARγ, FoxO1, Oxidative stress [more]
Organism: Mouse
Tissue: Eye
Influence of Decompression on the Expression of Inflammatory and Tissue Repair Biomarkers in Large Periapical Lesions
Dermatologica Sinica (Wolters Kluwer) Taiwan, 10 October 2024
Dermatology
Key words: Androgenetic alopecia; extracellular matrix; immunohistochemical staining; scalp stiffness [more]
Organism: Human
Tissue: Skin
Pathological State: Androgenetic Alopecia
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury
Cell Metabolism (Cell Press) China, 09 October 2024
Endocrinology, Hepathology
Key words: GPR56, 17α-hydroxypregnenolone, ferroptosis, liver injury [more]
Organism: Mouse
Tissue: Liver
Pathological State: Ferroptosis-induced liver injury
Enhancing intrinsic TGF-β signaling via heparan sulfate glycosaminoglycan regulation to promote mesenchymal stem cell capabilities and chondrogenesis for cartilage repair
Trends in Immunotherapy (EnPress) China, 09 October 2024
Oncology
Key words: tumor associate antigen (TAA), tumor-associated autoantibodies (TAA) induced autologous tumor antibodies (iATA), neu antigens, hapten, hapten induced immunotherapy [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Tumor-derived extracellular vesicles convey solute transporters to induce bioenergetic dependence shift contributing to treatment resistance
BMC Molecular and Cell Biology (Springer) China, 09 October 2024
Neuroscience
Key words: Ciclopirox olamine, Retina, Ischemia/reperfusion injury, Neuroprotection [more]
Organism: Rat
Tissue: Eye
Pathological State: Ischemia
Visualization of the dentogingival junction using micro‐plastination technique
Clinical Anatomy (Wiley) Chile, Brazil, 08 October 2024
Imaging
Key words: dentin, dentogingival junction, enamel, histological stains, micro, plastination, plastinationautofluorescence [more]
Organism: Human
Tissue: Tooth
Monocyte subsets in breast cancer patients under treatment with aromatase inhibitor and mucin-1 cancer vaccine
Journal of Translational Medicine (Springer) Austria, 08 October 2024
Oncology
Key words: Aromatase inhibitor, Breast cancer, Estrogen receptor, Letrozole, Monocyte, Stimuvax, Tecemotide [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Cross-Kingdom Pathogenesis of Pantoea alfalfae CQ10: Insights from Transcriptome and Proteome Analyses
Journal of Translational Medicine (Springer) Austria, 08 October 2024
Oncology
Key words: Aromatase inhibitor, Breast cancer, Estrogen receptor, Letrozole, Monocyte, Stimuvax, Tecemotide [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Antibody-Conjugated Nanodiamond Enzyme for Targeted Non-Small-Cell Lung Cancer by Regulating Oxidative Stress
ACS Applied Nano Materials (ACS Publications) China, 07 October 2024
Nanomedicine, Oncology
Key words: nanodiamond enzyme, nonsmall cell lung cancer, P40, ROS, TTF-1, oxidative stress
Phenotype remodelling of HNSCC cells in the muscle invasion environment
Journal of Translational Medicine (Springer) China, 07 October 2024
Oncology
Key words: Head and neck squamous cell carcinoma, Single-cell transcriptome, Spatial transcriptome, Phenotype remodelling, G0S2 [more]
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Biomarker potential of nuclear Nrf2 activation in the ABC subtype of diffuse large B‑cell lymphoma
Journal of Translational Medicine (Springer) China, 07 October 2024
Oncology
Key words: Head and neck squamous cell carcinoma, Single-cell transcriptome, Spatial transcriptome, Phenotype remodelling, G0S2 [more]
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Peripheral CD4+ T cell phenotype and brain microglial activation associated with cognitive heterogeneity in aged rats
ACS Applied Nano Materials (ACS Publications) China, 07 October 2024
Biomaterials
Key words: nanodiamondenzyme, nonsmall cell lungcancer,P40,ROS,TTF-1, oxidative stress [more]
Organism: Mouse
Tissue: Lung
Pathological State: Oxidative Stress
Interferon regulatory factor 7 alleviates the experimental colitis through enhancing IL-28A-mediated intestinal epithelial integrity
Journal of Translational Medicine (Springer) China, 06 October 2024
Immunology, Gastroenterology
Key words: IRF7, Colitis, IL-28A, Epithelial barrier, Interferon [more]
Organism: Mouse
Tissue: Colon
Pathological State: Colitis
Induced tumor associated autoantibodies (iTAAs) by hapten plus drugs for targeting oncogenic nuclear antigens at sentinel lymph node of pancreatic cancer
Journal of Translational Medicine (Springer) China, 06 October 2024
Gastroenterology
Key words: IRF, Colitis, IL-28A, Epithelial barrier, Interferon [more]
Organism: Mouse
Tissue: Colon
Pathological State: Inflammation
Dronedarone hydrochloride inhibits gastric cancer proliferation in vitro and in vivo by targeting SRC
Translational Oncology (Elsevier) China, 05 October 2024
Oncology, Pharmacology
Key words: Gastric cancer, Dronedarone hydrochloride, Cell proliferation, SRC/AKT1 signaling pathway [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment
Journal of Experimental & Clinical Cancer Research (Springer) China, 03 October 2024
Oncology
Key words: Pancreatic cancer, Metastasis, Inflammatory reprogramming, Cancer-associated fibroblasts, Organoids, CALB2, CXCL14 [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Neuroprotective effect of ciclopirox olamine in retinal ischemia/reperfusion injury
Clinical and Molecular Hepatology (Korean Association for the Study of the Liver) China, 02 October 2024
Hepathology
Key words: USP29, MASLD, ACSL5, Fatty acid β-oxidation, Deubiquitination [more]
Organism: Mouse
Tissue: Liver
Pathological State: Metabolic Dysfunction–Associated Fatty Liver Disease
Hexosaminidase B-driven cancer cell-macrophage co-dependency promotes glycolysis addiction and tumorigenesis in glioblastoma
Nature Communications (Nature) China, 01 October 2024
Oncology
Key words: Cancer metabolism, Cancer microenvironment, CNS cancer [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Epoxymicheliolide Reduces Radiation‐Induced Senescence and Extracellular Matrix Formation by Disrupting NF‐κB and TGF‐β/SMAD Pathways in Lung Cancer
Nature Communications (Nature) China, 01 October 2024
Oncology
Key words: Cancer metabolism, Cancer microenvironment, CNS cancer [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway
Investigative Ophthalmology & Visual Science (ARVO) China, 01 October 2024
Ophthalmology
Organism: Mouse
Tissue: Eye
Pathological State: Corneal Neovascularization
The Evolutionary Loss of Cardiac Regeneration: The Impact of the Ectotherm-to-Endotherm Transition
The Journal of Clinical Investigation (JCI) USA, 01 October 2024
Oncology
Organism: Human
Tissue: Brain
Pathological State: Cancer
Bioactive Matrix Scaffold of Oxidized Sacchachitin via Green Catalyst of SiliaCat TEMPO for Enhancing Bone Regeneration
Carbohydrate Polymer Technologies and Applications (Elsevier) Taiwan, 30 September 2024
Osteology
Key words: Carboxylate groups formation, Sacchachitin, Siliacat-tempo green fabrication, Mouse osteoblastic cells, In vivo bone regeneration, Bioactive matrix scaffold [more]
Organism: Rat
Tissue: Bone
Pathological State: Bone Damage
Lycium barbarum polysaccharide alleviates ferroptosis in Sertoli cells through NRF2/SLC7A11/GPX4 pathway and ameliorates DEHP-induced male reproductive damage in mice
Theranostics (Ivyspring) Singapore, 30 September 2024
Oncology
Key words: Extracellular Vesicles, TKI-resistance, SLC1A5, Tumor Microenvironment, metabolic reprogramming [more]
Organism: Human
Pathological State: Cancer
Cell Line: HCC827
Engineered 3D human neurovascular model of Alzheimer's disease to study vascular dysfunction
Biomaterials (Elsevier) USA, 28 September 2024
Neuroscience
Key words: Blood-brain barrier, Alzheimer's disease, Neurovascular unit, Perfusable 3D brain in vitro model, Amyloid-β [more]
Pathological State: Alzheimer's disease
Cell Line: human primary brain microvascular endothelial cells
The epigenetic-modified downregulation of LOXL1 protein mediates EMT in bladder epithelial cells exposed to benzo [a] pyrene and its metabolite BPDE
International Immunopharmacology (Elsevier) China, 27 September 2024
Oncology
Key words: Bladder Cancer, LOXL1, EMT, DNA methylation [more]
Organism: Rat
Tissue: Bladder
Pathological State: Cancer
Syntheses of LSD1/HDAC Inhibitors with Demonstrated Efficacy against Colorectal Cancer: In Vitro and In Vivo Studies Including Patient-Derived Organoids
Journal of Medicinal Chemistry (ACS Publications) Taiwan, 25 September 2024
Oncology
Key words: Cells, Genetics, Inhibitation, Inhibitors, Peptides and Proteins [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Application of Small Animal Ultrasound Imaging Technology for Identification of Polycystic Ovary Syndrome in a Mouse Model
Biochemical and Biophysical Research Communications (Elsevier) China, 23 September 2024
Reproductive Medicine
Key words: Ultrasonography, Polycystic ovary syndrome, Letrozole, High-fat diet, Model [more]
Organism: Mouse
Tissue: Ovaries
Pathological State: Polycystic ovary syndrome
Network Pharmacology and Metabolomics of Xinnaoxin Tablets for Antioxidant Stress in the Treat-ment of Coronary Heart Disease
Current Science (currentscience.info) China, 20 September 2024
Pharmacology
Key words: Metabolomics; Xinnaoxin tablet; Coronary heart disease; Keap1-Nrf2/HO-1 [more]
Organism: Rat
Tissue: Heart
Pathological State: Coronary Heart Disease
Functional and Proteomic Dissection of the Contributions of CodY, SigB and the Hibernation Promoting Factor HPF to Interactions of Staphylococcus aureus USA300 …
Journal of Proteome Research (ACS Publications) The Netherlands, Germany, 20 September 2024
Pulmonology
Key words: Staphylococcus aureus, SigB, CodY, SaHPF, Human Lung Epithelial Cells [more]
Organism: Human
Tissue: Lung
Pathological State: Bacterial Infection
Mitoguardin-2 promotes cell proliferation by activating AKT and regulating Hippo/YAP1 signaling pathway in ovarian granulosa cells
Journal of Proteome Research (ACS Publications) The Netherlands, Germany, 20 September 2024
Pulmonology
Key words: Staphylococcus aureus, SigB, CodY, SaHPF, Human Lung Epithelial Cells [more]
Organism: Human
Tissue: Lung
Pathological State: Bacterial Infection
BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice with Loss of the Polarity …
Cellular and Molecular Gastroenterology and Hepatology (Elsevier) USA, Japan, 19 September 2024
Neuroscience, Gastroenterology
Key words: Par3, Inflammation, ADM, Primary Cilia, BET Inhibitors [more]
Organism: Human
Tissue: Pancreas
Pathological State: Pancreatitis
Overexpression of NUDT16L1 sustains proper function of mitochondria and leads to ferroptosis insensitivity in colorectal cancer
Redox Biology (Elsevier) Taiwan, 18 September 2024
Oncology
Organism: Human
Pathological State: Cancer
Cell Line: CRL-1790
Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain
Neuroscience Bulletin (Springer) China, 15 September 2024
Neuroscience
Key words: Oxytocin receptor, RNAscope, Expression pattern, Postnatal development [more]
Organism: Mouse
Tissue: Brain
Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration
Experimental Neurology (Elsevier) Austria, USA, 15 September 2024
Neuroscience
Key words: Parkinson's disease, Alpha-synuclein, Dopamine neuron vulnerability, Adeno-associated viral vectors, Cre recombinase, Animal model of Parkinson's disease [more]
Organism: Mouse
Tissue: Brain
Pathological State: Viral Infection
Integrated bioinformatics analysis and experimental validation reveal the relationship between ALOX5AP and the prognosis and immune microenvironment in glioma
Purinergic Signalling (Springer) Brazil, Italy, 15 September 2024
Oncology
Key words: Tumor-associated macrophages, P2Y2 receptor, Purinergic signaling , Chemoresistance, Invasion [more]
Organism: Mouse
Tissue: Bone
Pathological State: Cancer
Immune Escape between Endoplasmic Reticulum Stress-Related Cancer Cells and Exhausted CD8+ T Cells Leads to Neoadjuvant Chemotherapy Resistance in …
Biochemical and Biophysical Research Communications (Elsevier) China, 14 September 2024
Oncology
Key words: Neoadjuvant chemotherapy, Endoplasmic reticulum stress, Ovarian cancer cell, Exhausted CD8+T cell, Immune escape [more]
Organism: Human
Tissue: Ovaries
Pathological State: Cancer
Advanced Electrospun Composites Based on Polycaprolactone Fibers Loaded with Micronized Tungsten Powders for Radiation Shielding
Polymers (MDPI) Italy, 13 September 2024
Biomaterials
Key words: shielding; polycaprolactone (PCL); tungsten powder; polymer composites; electrospinning; radiation protection; aerospace; healthcare industry [more]
Organism: Mouse
Tissue: Brain
Pathological State: Radiation
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
Cell (Cell) Germany, USA, Italy, Switzerland, 13 September 2024
Immunology
Key words: mitochondrial transfer, CD8+T celss, nanotubes, cancer immunotherapy, bone marrow stromal cells, Talin 2, CAR T therapy, TCR-T therapy, TIL therapy immune metabolism [more]
Organism: Mouse
Tissue: Bone Marrow
Imaging of Metabolic Activity Adaptations to UV Stress and Differentiation at Cellular Resolution in Skin and Skin Equivalents: Implications for Oxidative UV Damage
Cell (Cell) Germany, USA, Italy, Switzerland, 13 September 2024
Immunology
Key words: mitochondrial transfer, CD8+T celss, nanotubes, cancer immunotherapy, bone marrow stromal cells, Talin 2, CAR T therapy, TCR-T therapy, TIL therapy immune metabolism [more]
Organism: Mouse
Tissue: Bone Marrow
Combined use of CLP290 and bumetanide alleviates neuropathic pain and its mechanism after spinal cord injury in rats
CNS Neuroscience & Therapeutics (Wiley Online Library) China, 12 September 2024
Neuroscience
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Bestimmung der biologisch äquivalenten Dosis für die Mikrostrahltherapie
CNS Neuroscience & Therapeutics (Wiley Online Library) China, 12 September 2024
Neuroscience
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
滞动针干预 “激痛点” 对肌筋膜疼痛综合征模型大鼠中枢镇痛的作用机制
Chinese Journal of Tissue Engineering Research (Journal of Clinical Rehabilitative Tissue Engineering Research) China, 12 September 2024
Neuroscience
Key words: myofascial pain syndrome, myofascial trigger points, stagnant moving needle, central analgesia, brain-derived neurotrophic factor, periaqueductal gray [more]
Organism: Rat
Tissue: Muscle
Pathological State: Inflammation
Genome-wide characterization of dynamic DNA 5-hydroxymethylcytosine and TET2-related DNA demethylation during breast tumorigenesis
Clinical Epigenetics (BMC) China, 11 September 2024
Oncology
Key words: Breast tumorigenesis, DNA 5-hydroxymethylcytosine, 5-methylcytosine, DNA methylation, NA demethylation, TET2, cfDNA [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis
Scientific Reports (Nature) China, 10 September 2024
Physiology
Key words: Skeletal muscle fiber type, Mitochondrial biogenesis, Endurance exercise, Histone methylation, ROS, AMPK, Molecular bioloy, Physiology [more]
Organism: Rat
Tissue: Muscle
Pathological State: Tissue
Integrated MRI radiomics, tumor microenvironment, and clinical risk factors for improving survival prediction in patients with glioblastomas
Strahlentherapie und Onkologie (Springer) China, 09 September 2024
Oncology
Key words: Glioblastoma, Tumor microenvironment, Prognosis, Radiomics, Prediction model [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
Nature Communications (Nature) Taiwan, 09 September 2024
Oncology
Key words: Cancer therapeutic resistance, Glycobiology, Non-small-cell lung cancer [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Integration and competition between space and time in the hippocampus
Neuron (Cell Press) China, 05 September 2024
Neuroscience
Key words: place cell, time cell, navigation, spatiotemporal, episodic memory [more]
Organism: Mouse
Tissue: Brain
Glucocorticoid treatment increases cholesterol availability during critical illness: effect on adrenal and muscle function
Critical Care (BMC) Belgium, 05 September 2024
Immunology
Key words: Sepsis, Hypocholesterolemia, Muscle weakness, Adrenal failure, Aldosterone, Glucocoricoids [more]
Organism: Mouse
Tissue: Adrenal Gland
Pathological State: Hypocholesterolemia
TIM‐4 increases the proportion of CD4+CD25+FOXP3+ regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL‐6 secretion
Cancer Medicine (Wiley Online Library) China, 05 September 2024
Oncology
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response
Translational Oncology (Elsevier) Germany, Japan USA, 31 August 2024
Oncology
Key words: Pancreatic Cancer, Apoptosis, Autophagy, Molecular subtypes, GSK3-β, Histone deacetylases [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single‐cell suspension
Biotechnology Journal (Wiley) Czech Republic, Switzerland, 30 August 2024
Biotechnology
Key words: 3D cell culture, microfluidics, organoids, pluripotent stem cells, tissue engineering [more]
Tissue: Organoid
MULTIMODAL IMAGING OF CELLULAR SENESCENCE–OXIDIZED LIPIDS AND ENZYMATIC ADAPTATIONS IN AGING SKIN AT THE SINGLE CELL LEVEL
RedoXplore (RedoXplore) Austria, 29 August 2024
Dermatology
Organism: Human
Tissue: Skin
Pathological State: Aging
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in …
Acta Pharmacologica Sinica (Nature) China, USA, 29 August 2024
Neuroimaging
Key words: translocator protein 18 kDa, TSPO, D2-LW223, neuroinflammation, PET, 18F
Tumor microenvironment biomarkers predicting pathological response to neoadjuvant chemoimmunotherapy in locally advanced esophageal squamous cell carcinoma: post-hoc analysis of a single center, phase 2 study
Journal for ImmunoTherapy of Cancer (jitc.bmj.com) China, 28 August 2024
Oncology
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer
Science Translational Medicine (Science) USA, 28 August 2024
Oncology
The PARP inhibitor rucaparib blocks SARS‐CoV‐2 virus binding to cells and the immune reaction in models of COVID‐19
British Journal of Pharmacology (Wiley Online Library) Hungary, Brazil, UK, 27 August 2024
Virology
Organism: Human
Pathological State: Viral Infection
Cell Line: A549
Fibronectin type III domain containing 4 alleviates myocardial ischemia/reperfusion injury via the Nrf2-dependent antioxidant pathway
Free Radical Biology and Medicine (Elsevier) China, 26 August 2024
Cardiology
Key words: Myocardial ischemia/reperfusion injury, Fibronectin type III domain containing 4, Cardiomyocyte apoptosis, Oxidative stress, Nrf2 [more]
Cell Line: iPSC-CMs
Hepatic and metabolic outcomes induced by sub-chronic exposure to polystyrene microplastics in mice
Archives of Toxicology (Springer) Taiwan, 25 August 2024
Toxicology
Key words: Microplastics, Sub-chronic exposure, Hepatotoxicity, Mouse model, Metabolic dysfunction, Non-alcoholic steatohepatitis [more]
Organism: Mouse
Tissue: Liver
Identification of a novel alternative splicing isoform of the Hippo kinase STK3/MST2 with impaired kinase and cell growth suppressing activities
Oncogene (Nature) Brazil, USA, 22 August 2024
Biochemistry, Cell Biology
Cell Line: T4–2 cells, HEK293FT cells
Tolerance and toxicity assessment of a novel methionine source, dipeptide Met-Met on common carp Cyprinus carpio
Aquaculture (Elsevier) China, 22 August 2024
Toxicology
Key words: Met-Met, Safety assessment, Overdose, Metabolites, Common carp [more]
Organism: Common Carp
Tissue: Small Intestine
Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction …
Journal of Pharmaceutical Analysis (Elsevier) China, Japan, 22 August 2024
Oncology
Key words: Traditional Chinese medicine, Polypyrimidine tract binding protein 1, Alpha actinin-4, Gastric Cancer, Actin skeleton remodelling [more]
Organism: Mouse
Tissue: Stomach
Pathological State: Cancer
Extracellular vesicles of the probiotic E. coli O83 activate innate immunity and prevent allergy in mice
Journal of Pharmaceutical Analysis (Elsevier) China, Japan, 22 August 2024
Oncology
Key words: Traditional Chinese medicine, Polypyrimidine tract binding protein 1, Alpha actinin-4, Gastric Cancer, Actin skeleton remodelling [more]
Organism: Mouse
Tissue: Stomach
Pathological State: Cancer
Integrated bioinformatics analysis and experimental validation reveal the relationship between ALOX5AP and the prognosis and immune microenvironment in …
BMC Medical Genomics (Springer) China, 21 August 2024
Oncology
Key words: Glioma, ALOX5AP, Multiplex Immunoflorescence, Tumor-associated macrophage, Prognosis [more]
Organism: Human
Pathological State: Cancer
Cell Line: ndGBM_02
TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in …
Cell Death & Disease (Nature) China, 21 August 2024
Oncology
Key words: Cancer therapy, Predictive markers [more]
Organism: Mouse
Tissue: Stomach
Pathological State: Cancer