Customer Publications (A total of 2076 papers published)

Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

R Liu, J Li, Y Xu, Z Chen, H Ye, J Tang, L Wei, L Liang

Investigative Ophthalmology & Visual Science (ARVO Journals) China, 26 May 2022

Ophthalmology

[more]

Catalpol Attenuates Pulmonary Fibrosis by Inhibiting Ang II/AT1 and TGF-β/Smad-Mediated Epithelial Mesenchymal Transition

Q Yu, D Zhu, Y Zou, K Wang, P Rao, Y Shen

Frontiers in Medicine (Frontiers Media S.A.) China, 24 May 2022

Pulmonology

Key words: idiopathic pulmonary fibrosis, Ang II, TGF-β/Smad signaling pathway, EMT, catalpol [more]

Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

R Ghiarasim, CE Tiron, A Tiron, MG Dimofte, M Pinteala, A Rotaru

Nanomaterials (MDPI) Romania, 24 May 2022

Nanomedicine

Key words: polyhistidine copolymers, micelles, doxorubicin, tumor cells, release studies [more]

Tumor acidity-responsive polymeric nanoparticles to promote intracellular delivery of zoledronic acid by PEG detachment and positive charge exposure for enhanced antitumor potency

YH Chou, YL Liu, TC Hsu, JL Yow, BS Tzang, WH Chiang

Journal of Materials Chemistry B (Royal Society of Chemistry) Taiwan, 23 May 2022

Nanomedicine

Key words: Endocrinology [more]

Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma

P Chuntova, A Yamamichi, T Chen, R Narayanaswamy, S Ronseaux, C Hudson, AE Tron, ML Hyer, M Montoya, AL Mende, T Nejo, KM Downey, D Diebold, M Lu, B Nicolay, H Okada

Journal for ImmunoTherapy of Cancer (BMJ Journals) USA, 23 May 2022

Oncology, Immunology

Key words: Brain Neoplasms, Central Nervous System Neoplasms, Drug Evaluation, Preclinical, Programmed Cell Death 1 Receptor, Vaccination [more]

Topography-Mediated Enhancement of Nonviral Gene Delivery in Stem Cells

L Ge, L Yang, R Bron, P van Rijn

Pharmaceutics (MDPI) China, The Netherlands, 20 May 2022

Pharmacology

Key words: topography, proliferation, gene delivery, endocytosis, transfection [more]

Adverse Effects of Single Neutrophil Extracellular Trap-Derived Components on Bovine Sperm Function

C Moya, R Rivera-Concha, F Pezo, P Uribe, M Schulz, R Sánchez, C Hermosilla, A Taubert, U Gärtner, F Zambrano

Animals (MDPI) Chile, Germany, 20 May 2022

Reproductive Medicine, Zoology

Key words: bovine, spermatozoon, bull, neutrophil extracellular traps, membrane integrity [more]

Di-(2-ethylhexyl) Phthalate Promotes Allergic Lung Inflammation by Modulating CD8α+ Dendritic Cell Differentiation via Metabolite MEHP-PPARγ Axis

HH Tseng, CY Li, ST Wu, HH Su, TH Wong, HE Wu, YW Chang, SK Huang, EM Tsai, JL Suen

Frontiers in Immunology (Frontiers Media S.A.) Taiwan, USA, 19 May 2022

Immunology

Key words: allergic lung inflammation, dendritic cell, PPAR γ, low-dose exposure, di-(2-ethylhexyl) phthalate, mono-(2-ethylhexyl) phthalate (MEHP) [more]

Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts

X Li, T Yong, Z Wei, N Bie, X Zhang, G Zhan, J Li, J Qin, J Yu, B Zhang, L Gfan, X Yang

Nature Communications (Nature) China, 19 May 2022

Oncology

Key words: Cancer immunotherapy, Cancer therapeutic resistance, Drug delivery [more]

Adenosine ameliorated Aβ25− 35-induced brain injury through the inhibition of apoptosis and oxidative stress via an ERα pathway

M Zeng, A Feng, C Zhao, B Zhang, P Guo, M Liu, Q Zhang, Y Zhang, R Fan, J Lyu, X Zheng

Brain Research (Elsevier) China, 18 May 2022

Neuroscience

Key words: Adenosine, Brain injury, ERα, Apoptosis, Oxidative stress [more]

Combination neoantigen-based dendritic cell vaccination and adoptive T-cell transfer induces antitumor responses against recurrence of hepatocellular carcinoma

S Peng, S Chen, W Hu, J Mei, X Zeng, T Su, W Wang, Z Chen, H Xiao, Q Zhou, B Li, Y Xie, H Hu, M He, Y Han, L Tang, Y Ma, X Li, X Zhou, Z Dai, Z Liu, J Tan, L Xu, S Li, S Shen, D Li, J Lai, B Peng, Z Peng, M Kuang

Cancer Immunology Research (AACR) China, 18 May 2022

Oncology, Immunology

[more]

Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

M Schepelmann, M Ranieri, I Lopez-Fernandez, TS Webberley, SC Brennan, PL Yarova, J Graca, UK Hanif, C Müller, T Manhardt, M Salzmann, H Quasnichka, SA Price, DT Ward, T Gilbert, VV Matchkov, RA Fenton, A Herberger, J Hwong, C Santa Maria, CL Tu, E Kallay, G Valenti, W Chang, D Riccardi

Journal of The American Society of Nephrology (ASN) UK, Austria, Italy, Australia, USA, France, Denmark, 17 May 2022

Endocrinology

Key words: calcium-sensing receptor, mineral metabolism, vascular calcification, hypercalcemia, transgenic mouse, vascular smooth muscle [more]

Downregulated ADAMTS1 Incorporating A2M Contributes to Tumorigenesis and Alters Tumor Immune Microenvironment in Lung Adenocarcinoma

HC Lee, CY Chang, YC Huang, KL Wu, HH Chiang, YY Chang, LX Liu, JY Hung, YL Hsu, YY Wu, YM Tsai

Biology (MDPI) Taiwan, 16 May 2022

Oncology

Key words: A2M, ADAMTS1, EMT, immunity, LUAD, metastasis [more]

Organ‐specific immune response in lethal SARS‐CoV‐2 infection by deep spatial phenotyping

A Balachander, B Lee, SK Biswas, DC Lye, RTP Lin, YS Leo, P Chui, LFP Ng, L Renia

Clinical & Translational Immunology (Wiley) Singapore, 15 May 2022

SARS-CoV-2, Immunology

Key words: COVID-19, immunopathology, in situ spatial multiplexing, SARS-CoV-2 infection [more]

Translocon-associated protein subunit SSR3 determines and predicts susceptibility to paclitaxel in breast cancer and glioblastoma

C Dmello, A Sonabend, VA Arrieta, DY Zhang, D Kanojia, L Chen, A Gould, J Zhang, SJ Kang, J Winter, C Horbinski, C Amidel, B Győrffy, A Cordero, C Lee-Chang, B Castro, P Hsu, AU Ahmend, MS Lesniak, R Stupp, AM Sonabend

Clinical Cancer Research (AACR) USA, Germany, Hungary, 12 May 2022

Oncology

Key words: Paclitaxel, biomarker, glioblastoma, breast cancer, SSR3 [more]

Novel Elastic Threads for Intestinal Anastomoses: Feasibility and Mechanical Evaluation in a Porcine and Rabbit Model

SM Schmitz, MJ Helmedag, KM Kossel, RM Eickhoff, D Heise, A Kroh, M Mechelinck, T Gries, S Jockenhoevel, UP Neumann, A Lambertz

International Journal of Molecular Sciences (MDPI) Germany, The Netherlands, 11 May 2022

Tissue Engineering

Key words: biomaterial, TPU, surgical thread, suture material, elastic suture, gastrointestinal anastomosis

In vitro testicular toxicity of environmentally relevant endocrine-disrupting chemicals: 2D vs. 3D models of prepubertal Leydig TM3 cells

E Sychrová, A Yawer, P Labohá, A Basu, A Dydowiczová, I Virmani, P Babica, I Sovadinová

Environmental Toxicology and Pharmacology (Elsevier) Czech Republic, 10 May 2022

Reproductive Medicine, Toxicology

Key words: 3D in vitro models, Endocrine-disrupting chemicals, Leydig cells, Lipotoxicity, Reproductive toxicity, Spheroids [more]

AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice—A Pilot Study

M Schepelmann, N Kupper, V Gushchina, I Mesteri, T Manhardt, S Moritsch, S Müller, K Piatek, M Salzman, A Vlasaty, R Eferl, E Kallay

International Journal of Molecular Sciences (MDPI) Austria, Germany, 09 May 2022

Oncology, Gastroenterology

Key words: aged mice, colitis associated colorectal cancer, AOM, DSS, mouse strain differences, pilot study [more]

Macrophage-associated immune checkpoint CD47 blocking ameliorates endometriosis

J Li, S Yan, Q Li, Y Huang, M Ji, X Jiao, M Yuan, G Wang

Molecular Human Reproduction (Oxford Academic) China, 05 May 2022

Reproductive Medicine

Key words: apoptosis, endometriosis, immune checkpoint, immunotherapy, macrophage, phagocytosis [more]

DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide

MT Latancia, NC Moreno, GS Leandro, V Chaves Ribeiro, I de Souza, W Kleber Martins Vieira, A Uchimura Bastos, NC Hoch CRR Rocha, CFM Menck

Mutation Research/Genetic Toxicology and Environmental Mutagenesis (Elsevier) Brazil, 05 May 2022

Toxicology

Key words: XP-V, Temozolomide, Polymerase eta, DNA damage, Translesion synthesis, Cisplatin [more]

Hybrid PEGylated chitosan/PLGA nanoparticles designed as pH-responsive vehicles to promote intracellular drug delivery and cancer chemotherapy

SJ Huang, TH Wang, YH Chou, HMD Wang, TC Hsu, JL Yow, BS Tzang, WH Chiang

International Journal of Biological Macromolecules (Elsevier) Taiwan, 05 May 2022

Nanomedicine, Oncology

Key words: Acidity-responsive nanovehicles, PEGylated chitosan, cancer chemotherapy [more]

Multinucleated Retinal Pigment Epithelial Cells Adapt to Vision and Exhibit Increased DNA Damage Response

Q Ke, L Gong, X Zhu, R Qi, M Zou, B Chen, W Liu, S Huang, Y Liu, DWC Li

Cells (Cell Press) China, 05 May 2022

Key words: multinucleation, retinal pigment epithelium, reactive oxygen species, photoreceptor, DNA damage, p53 [more]

miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization

N Li, X Wang, J Sun, Y Liu, A Han, Z Lin, Y Yang

Carcinogenesis (Oxford Academic) China, 02 May 2022

Oncology

Key words: Tiam1, breast cancer, metastasis, glucose metabolism reprogramming, miR-21-5p [more]

SAM and folic acid prevent arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells by modulating expression of inflammatory and DNA repair genes

T Boonma, P Navasumrit, V Parnlob, S Waraprasita, M Ruchirawatac

Chemico-Biological Interactions (Elsevier) Thailand, 02 May 2022

Toxicology

Key words: Arsenic, S-adenosyl methionine (SAM), Folic acid, DNA methylation, 8-hydroxydeoxyguanosine (8-OHdG), 8-nitroguanine [more]

Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse

W Huang, Q Xu, F Liu, J Su, D Xiao, L Tang, ZZ Hao, R Liu, K Xiang, Y Bi, Z Miao, X Liu, Y Liu, S Liu

Investigative Ophthalmology & Visual Science (ARVO Journals) China, UK, 02 May 2022

Ophthalmology, Neuroscience

[more]

Prognostic Value of Characterizing Myocardial Tissue by Cardiac MRI with T1 Mapping in HFpEF Patients: A Systematic Review and Meta-Analysis

E Golukhova, N Bulaeva, S Alexandrova, O Gromova, B Berdibekov

Journal of Clinical Medicine (MDPI) Russia, 30 April 2022

Cardiology

Key words: cardiac MRI, HFpEF, T1 mapping, extracellular volume, native T1, postcontrast T1, prognosis

Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model

JF Fu, CJ Wen, TH Yen, LY Shih

Neoplasia (Elsevier) Taiwan, 29 April 2022

Oncology

Key words: MLL translocation, KRAS mutation, Hoxa11, Hoxa10, Myeloid sarcoma, Migration [more]

The Overexpression of Insulin-Like Growth Factor-1 and Neurotrophin-3 Promote Functional Recovery and Alleviate Spasticity After Spinal Cord Injury

Z Talifu, C Qin, Z Xin, Y Chen, J Liu, S Dangol, X Ma, H Gong, Z Pei, Y Yu, J Li, L Du

Frontiers in Neuroscience (Frontiers Media S.A.) China, 29 April 2022

Neuroscience

Key words: spinal cord injury, nerve repair, nerve growth factor, NT-3, IGF-1, motor function recovery, spasticity, mechanical pain [more]

Epidermotropism of inflammatory cells differentiates pyoderma gangrenosum from venous leg ulcers

M Ronicke, A Baur, M Kirr, M Erdmann, C Erfurt-Berge, C Ostalecki

JDDG: Journal of the German Society of Dermatology (Wiley) Germany, 29 April 2022

Dermatology

[more]

Prognostic values of B7-H3, B7-H4, and HHLA2 expression in human pancreatic cancer tissues based on mIHC and spatial distribution analysis

Y Zhu, J Chen, Y Liu, X Zheng, J Feng, X Chen, T Jiang, Y Li, L Chen

Pathology-Research and Practice (Elsevier) China, 29 April 2022

Oncology

Key words: B7-H3, B7-H4, HHLA2, Multi-color immunohistochemistry, Prognosis, Pancreatic cancer [more]

Corallodiscus flabellata BL Burtt extract and isonuomioside A ameliorate Aβ25− 35-induced brain injury by inhibiting apoptosis, oxidative stress, and autophagy via the NMDAR2B/CamK Ⅱ/PKG pathway

M Zeng, A Feng, M Li, M Liu, P Guo, Y Zhang, Q Zhang, B Zhang, B Cao, J Jia, R Wang, J Lyu, X Zheng

Phytomedicine (Elsevier) China, 27 April 2022

Toxicology

Key words: Isonuomioside A, Corallodiscus flabellata B. L. Burtt extract, NMDAR2B, Apoptosis, Oxidative stress, Autophagy [more]

PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

X Tan, J Bednarsch, M Rosin, S Appinger, D Liu, G Wiltberger, J Garcia Vallejo, SA Lang, Z Czigany, S Boroojerdi, NT Gaisa, P Boor, RD Bülow, J De Vos-Geelen, L Valkenburg-van Iersel, MC Clahsen-van Groningen, EJM de Jong, BG Koerkamp, M Doukas, FG Rocha, T Luedde, U Klinge, S Sivakumar, UP Neumann, LR Heij

Cancers (MDPI) Germany, The Netherlands, USA, UK, 27 April 2022

Oncology

Key words: cholangiocarcinoma, liver cancer, tumor microenvironment, nerve fiber density, immune checkpoint, immune cells [more]

Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target

BC Moraes, HV Ribeiro-Filho, AP Roldão, EF Toniolo, GPB Carretero, GG Sgro, FAH Batista, DE Berardi, VRS Oliveira, R Tomasin, FM Vieceli, DT Pramio, AB Cardoso, ACM Figueira, SC Farah, LA Devi, CS Dale, PSL de Oliveira, D Schechtman

Science Signaling (Science) Brazil, USA, 26 April 2022

Pharmacology

Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site

Y Jing, F Bai, L Wang, D Yang, Y Yan, Q Wang, Y Zhu, Y Yu, Z Chen

Microbiology Spectrum (ASM Journals) China, 25 April 2022

Microbiology, Neuroscience

[more]

Oxidative Stress-Induced Growth Inhibitor (OSGIN1), a Target of X-Box-Binding Protein 1, Protects Palmitic Acid-Induced Vascular Lipotoxicity through Maintaining Autophagy

CS Khoi, CQ Xiao, KY Hung, TY Lin, CK Chiang

Biomedicines (MDPI) Taiwan, 25 April 2022

Cell Biology

Key words: palmitic acid, OSGIN1, unfolded protein response, XBP1s, autophagy, eNOS, endothelial cells [more]

HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

X Lu, K Fong, G Gritsina, F Wang, SC Baca, LT Brea, JE Berchuck, S Spisak, J Ross, C Morrissey, E Corey, NS Chandel, WJ Catalona, X Yang, ML Freedman, JC Zhao, J Yu

Nature Genetics (Nature) USA, 25 April 2022

Oncology

Key words: Epigenomics, Prostate cancer, Targeted therapies [more]

HLA class I downregulation in progressing metastases of melanoma patients treated with ipilimumab

A Ladányi, B Hegyi, T Balatoni, G Liszkay, R Rohregger, C Waldnig, J Dudás, S Ferrone

Pathology and Oncology Research (Elsevier) Hungary, Austria, USA, 22 April 2022

Oncology

Key words: immunotherapy, melanoma, ipilimumab, HLA class I expression, longitudinal study [more]

Increased fatty acid metabolism attenuates cardiac resistance to β-adrenoceptor activation via mitochondrial reactive oxygen species: A potential mechanism of hypoglycemia-induced myocardial injury in diabetes

L Huang, Z Chen, R Chen, L Lin, L Ren, M Zhang, L Liu

Redox Biology (Elsevier) China, 21 April 2022

Endocrinology

Key words: Hypoglycemia, Diabetes, Lipid metabolism, β-adrenoceptor, Mitochondrial reactive oxygen species [more]

CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by

C Liu, X Cheng, J Xing, J Li, Z Li, D Jian, Y Wang, S Wang, R Li, W Zhang, D Shao, X Ma, X Chen, J Shen, C Shi, Z Gao, W Wang, T Fan, L Liu, H Tang

International Journal of Biological Sciences (Ivyspring International Publisher) China, 20 April 2022

Cardiology, Oncology

Key words: CIRBP, Cardioprotection, OGFR, Chemotherapy-induced cardiotoxicity, Cardiomyocyte apoptosis [more]

CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis

DW Zhang, JJ Ye, Y Sun, S Ji, JY Kang, YY Wei, GH Fei

Journal of Inflammation Research (Dovepress) China, 20 April 2022

Pulmonology

Key words: chronic obstructive pulmonary disease, emphysema, B cell, bioinformatics analysis [more]

Endocrine-disrupting chemicals affect sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro

A Yawer, E Sychrová, J Raška, P Babica, I Sovadinová

Food and Chemical Toxicology (Elsevier) Czech Republic, 19 April 2022

Reproductive Medicine

Key words: Connexins, Endocrine-disrupting chemicals, Gap junctional intercellular communication, Reproductive toxicity, Sertoli cells, Testicular tumors [more]

Computer-assisted evaluation enhances the quantification of interstitial fibrosis in renal implantation biopsies, measures differences between frozen and paraffin sections, and predicts delayed graft function

M Pavlovic, A Oszwald, Ž Kikić, MC Nackenhorst, R Kain, N Kozakowski

Journal of Nephrology (Springer) Austria, France, 19 April 2022

Medical Image Analysis

Key words: Implantation biopsy, Interstitial fibrosis, Computer-assisted evaluation, Delayed graft function [more]

Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging

N Mori, C Inoue, H Tamura, T Nagasaka, H Ren, S Sato, Y Mori, M Miyashita, S Mugikura, K Takase

Magnetic Resonance Imaging (Elsevier) Japan, 16 April 2022

Medical Imaging

Key words: Breast cancer, Magnetic resonance imaging, Diffusion weighted imaging, Diffusion kurtosis imaging, Histology [more]

The significance of NAD+ metabolites and nicotinamide N-methyltransferase in chronic kidney disease

R Takahashi, T Kanda, M Komatsu, T Itoh, H Minakuchi, H Urai, T Kuroita, S Shigaki, T Tsukamoto, N Higuchi, M Ikeda, R Yamanaka, N Yoshimura, T Ono, H Yukioka, K Hasegawa, H Tokuyama, S Wakino, H Itoh

Scientific Reports (Nature) Japan, 16 April 2022

Nephrology

Key words: Medical research, Nephrology [more]

Robust delivery of RIG‐I agonists using extracellular vesicles for anti‐cancer immunotherapy

B Peng, TM Nguyen, MK Jayasinghe, C Gao, TT Pham, LT Vu, EYM Yeo, G Yap, L Wang, BC Goh, WL Tam, D Luo, MTN Le

Journal of Extracellular Vesicles (Wiley) Singapore, 16 April 2022

Oncology

[more]

Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway

Y Sun, Y Qian, C Chen, H Wang, X Zhou, W Zhai, L Qiu, X Zhou, H Ning, Y Zhao, C Shi, L Han, Y Qi, Y Wu, Y Gao

Journal of Experimental & Clinical Cancer Research (BMC) China, 15 April 2022

Oncology

Key words: Esophageal squamous cell carcinoma, IL-32, Extracellular vesicle, M2 macrophage polarization, Metastasis [more]

Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice

YH Mao, Y Xu, F Song, ZM Wang, YH Li, M Zhao, F He, Z Tian, Y Yang

Carbohydrate Polymers (Elsevier) China, 14 April 2022

Gastroenterology

Key words: Polysaccharides, Molecular weight, Prebiotic fiber, Protection, Dysbiosis [more]

AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia

E Gonçalves-Alves, M Garcia, CJ Rodríguez-Hernández, S Gómez-González, R Ecker, M Suñol, O Muñoz-Aznar, AM Carcaboso, J Mora, C Lavarino, S Mateo-Lozano

International Journal of Molecular Sciences (MDPI) Spain, Austria, 13 April 2022

Oncology

Key words: neuroblastoma, calcium-sensing receptor, calcimimetic, cinacalcet, AC-265347, biased signaling, differentiation, cancer-testis antigens [more]

Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome

P Guo, M Zeng, S Wang, B Cao, M Liu, Y Zhang, J Jia, Q Zhang, B Zhang, R Wang, X Zheng, W Feng

Molecules (MDPI) China, 12 April 2022

Neuroscience

Key words: eriodictyol, homoeriodictyol, NLRP3 inflammasome, Alzheimer’s disease, Aβ25–35 [more]

Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy

H Kong, H Zhao, T Chen, Y Song, Y Cui

Cell Death & Disease (Nature) China, 12 April 2022

Ophthalmology

Key words: Apoptosis, Cell death [more]

A phase 1b study of OXIRI in pancreatic adenocarcinoma patients and its immunomodulatory effects

M Ng, S Chen, WS Ong, A Balachander, A Seet, J Yeong, N Sutiman, TKH Lim, B Lee, YA Guo, WF Leong, SS Lee, J Lam, SP Choo, AJ Skanderup, SK Biswas, D Tai, B Chowbay

International Journal of Cancer (Wiley) Singapore, 12 April 2022

Oncology

Key words: PDAC, OXIRI, metronomic oxaliplatin, chronomodulated capecitabine, UGT1A1, irinotecan [more]

Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy

MK Jayasinghe, M Pirisinu, Y Yang, B Peng, TT Pham, CY Lee, M Tan, L Tien Vu, XTT Dang, TC Pham, H Chen, AYH Leung, WC Cho, J Shi, MTN Le

Theranostics (Ivyspring International Publisher) Singapore, Hong Kong, China, 11 April 2022

Oncology

[more]

ERBB2D16 Expression in HER2 Positive Gastric Cancer Is Associated With Resistance to Trastuzumab.

S Wang, Y Zhao, Y Song, G Qiao, Y Di, J Zhao, P Sun, H Zheng, H Huang, H Huang

Frontiers in Oncology (Frontiers Media S.A.) China, 07 April 2022

Oncology

Key words: gastric cancer, ERBB2d16, epithelial-mesenchymal transition, immunosuppression, trastuzumab resistance [more]

Rho kinase inhibition ameliorates vascular remodeling and blood pressure elevations in a rat model of apatinib-induced hypertension

C Li, L Ma, Q Wang, X Shao, L Guo, J Chen, W Wang, J Yu

Journal of Hypertension (Wolters Kluwer) China, 07 April 2022

Cardiology

Key words: RhoA/Rho-associated coiled-coil domain-containing protein kinase signaling pathway, apatinib, hypertension, tyrosine kinase inhibitors, vascular endothelial growth factor

Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice

C Huang, Y Wang, P Chen, QH Shan, H Wang, LF Ding, GQ Bi, JN Zhou

Communications Biology (Nature) China, 06 April 2022

Neuroscience

Key words: 3-D reconstruction, Fluorescence imaging, Light-sheet microscopy, Neural circuits, Viral tracing [more]

Inhibition of CXXC5 function reverses obesity‐related metabolic diseases

SH Seo, E Kim, SH Lee, Y Lee, DH Han, H Go, JK Seong, KY Choi

Clinical and Translational Medicine (Wiley) South Korea, 05 April 2022

Endocrinology

[more]

Inhibiting MNK kinases promotes macrophage immunosuppressive phenotype to limit CD8+ T cell anti-tumor immunity

TND Pham, C Spaulding, MA Shields, AE Metropulos, DN Shah, MG Khalafalla, DR Principe, DJ Bentrem, HG Munshi

JCI Insight (American Society for Clinical Investigation) USA, 05 April 2022

Immunology, Oncology

Key words: MNK kinases, tumor-associated macrophages, CD8+ T cells, immunotherapy, antiPD-1 antibody, anti-CSF-1R antibody, pancreatic cancer, thyroid cancer [more]

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

CC Gao, M Li, W Deng, CH Ma, YS Chen, YQ Sun, T Du, QL Liu, WJ Li, B Zhang, L Sun, SM Liu, F Li, F Qi, Y Qu, X Ge, J Liu, P Wang, Y Niu, Z Liang, YL Zhao, B Huang, XZ Peng, Y Yang, C Qin, WM Tong, YG Yang

Protein & cell (Springer) China, 04 April 2022

SARS-CoV-2, Immunology

Key words: SARS-CoV-2, NRP1, inflammation, central nervous system, viral encephalitis, rhesus macaque [more]

KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion

X Han, C Wang, L Song, X Wang, S Tang, T Hou, C Liu, X Liang, C Qiu, Y Wang, Y Du

EBioMedicine (Elsevier) China, Sweden, 01 April 2022

Cell Biology, Neuroscience

Key words: Extracellular vesicles, Lysosomes, KIBRA, Amyloid β, Alzheimer's disease [more]

Extracellular Vesicles Derived from SIPA1high Breast Cancer Cells Enhance Macrophage Infiltration and Cancer Metastasis through Myosin-9

L Feng, J Weng, C Yao, R Wang, N Wang, Y Zhang, Y Tanaka, L Su

Biology (MDPI) China, Japan, 31 March 2022

Oncology

Key words: breast cancer, extracellular vesicles, macrophage, myosin-9, SIPA1 [more]

Prenatal infection predisposes offspring to enhanced susceptibility to imiquimod-mediated psoriasiform dermatitis in mice

S Yu, CW Lee, YA Li, TH Chen, HS Yu

Dermatologica Sinica (Taiwanese Society for Investigative Dermatology) Taiwan, 30 March 2022

Dermatology

Key words: Bacterial infection, lipopolysaccharide, polyinosinic:polycytidylic acid, psoriasis, psoriatic arthritis, viral infection [more]

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19

N Kaneko, J Boucau, HH Kuo, C Perugino, VS Mahajan, JR Farmer, H Liu, TJ Diefenbach, A Piechocka-Trocha, K Lefteri, MT Waring, KR Premo, BD Walker, JZ Li, G Gaiha, XG Yu, M Lichterfeld, RF Padera Jr, S Pillai

Clinical Immunology (Elsevier) USA, Japan, 29 March 2022

SARS-CoV-2, Immunology

Key words: COVID-19, CD8+ T cells, Cytotoxic CD4+ T cells [more]

FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway

Y Zhang, Y Wang, G Zhao, EJ Tanner, M Adli, D Matei

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 29 March 2022

Oncology

[more]

Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration

M Zou, Q Ke, Q Nie, R Qi, X Zhu, W Liu, X Hu, Q Sun, JL Fu, X Tang, Y Liu, DWC LI, L Gong

Cell Death & Differentiation (Nature) China, 28 March 2022

Ophthalmology

Key words: Drug development, Epigenetics [more]

Food Allergen Nitration Enhances Safety and Efficacy of Oral Immunotherapy in Food Allergy

N Samadi, L Koidl, M Salzmann, M Klems, N Komatitsch, D Schaffer, E Weidmann, A Duschi, J Horejs-Hoeck, E Untersmayr

Nutrients (MDPI) Austria, 25 March 2022

Allergy Research

Key words: oral immunotherapy, food allergy, protein nitration, modulated immune response [more]

Effects of Magnetite Nanoparticles and Static Magnetic Field on Neural Differentiation of Pluripotent Stem Cells

AT Semeano, FA Tofoli, JC Corrêa-Velloso, AP de Jesus Santos, Á Oliveira-Giacomelli, RR Cardoso, MA Pessoa, E Lummertz da Rocha, G Ribeiro, MZR Ferrari, LV Pereira, YD Teng, DFS Petri, H Ulrich

Stem Cell Reviews and Reports (Springer) Brazil, USA, 24 March 2022

Stem Cell Research, Nanomedicine

Key words: Neural differentiation, Magnetic nanoparticles, Magnetic field, Biomagnetic effects, Embryonic stem cells, iPSCs, Dopaminergic neurons [more]

Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells Mitigate Endoplasmic Reticulum Stress, Inflammation, and Lung Injury in Lipopolysaccharide-Treated Obese Mice

MD Chiang, CY Chang, HJ Shih, VL Le, YH Huang, CJ Huang

Antioxidants (MDPI) Taiwan, Vietnam, 23 March 2022

Endocrinology

Key words: lung injury, obesity, endoplasmic reticulum stress, exosomes, LPS [more]

Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway

Y Li, H Liu, X Liu, B Xiao, M Zhang, Y Luo, M Li, J Yang

Frontiers in Oncology (Frontiers Media S.A.) China, 22 March 2022

Oncology, Pharmacology

Key words: gracillin, non-small cell lung cancer, autophagy, mTOR signaling pathway, anti-tumor [more]

A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer

PH Chou, CK Luo, N Wali, WY Lin, SK Ng, CH Wang, M Zhao, SW Lin, PM Yang, PJ Liu, JJ Shie, TT Wei

Journal of Biomedical Science (BMC) Taiwan, USA, 22 March 2022

Oncology

Key words: STAT1, Colorectal cancer, Stemness, Angiogenesis, 4’,5,7-trihydroxyisoflavone (THIF), BODIPY-THIF [more]

Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model

H Scherthan, SQ Wagner, J Grundhöfer, N Matejka, J Müller, S Müller, S Rudigkeit, M Sammer, S Schoof, M Port, J Reindl

Cancers (MDPI) Germany, 17 March 2022

Radiotherapy

Key words: 53BP1, cell death, DNA damage, epidermis, γ-H2AX, proton minibeam radiation therapy, DNA repair, skin model [more]

Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis

M Wu, X Zhang, W Zhang, YS Chiou, W Qian, X Liu, M Zhang, H Yan, S Li, T Li, X Han, P Qian, S Liu, Y Pan, PE Lobie, T Zhu

Nature communications (Nature) China, Taiwan, 16 March 2022

Oncology

Key words: Breast cancer, Cancer stem cells, Cancer therapy, Metastasis, Tumour heterogeneity [more]

Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway

J Lv, Y Liu, S Mo, Y Zhou, F Chen, F Cheng, C Li, D Saimi, M Liu, H Zhang, K Tang, J Ma, Z Wang, Q Zhu, WM Tong, B Huang

Nature Cell Biology (Nature) China, 15 March 2022

Oncology

Key words: Glycoproteins, Mechanisms of disease, Pancreatic cancer [more]

Regorafenib Reverses Temozolomide-Induced CXCL12/CXCR4 Signaling and Triggers Apoptosis Mechanism in Glioblastoma

I Chiang, YC Liu, HS Liu, AAA Ali, SY Chou, TI Hsu, FT Hsu

Neurotherapeutics (Springer) Taiwan, 10 March 2022

Oncology

Key words: Glioblastoma, Temozolomide, Regorafenib, NF-κB, CXCR4/CXCL12 [more]

hsa-miR-875-5p inhibits tumorigenesis and suppresses TGF-β signalling by targeting USF2 in gastric cancer

S Gao, Z Zhang, X Wang, Y Ma, C Li, H Liu, C Jing, L Li, X Guo

Journal of Translational Medicine (Springer) China, 07 March 2022

Oncology

Key words: miR-875-5p, USF2, Gastric cancer, TGF-β [more]

Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy

W Jiang, W Dong, M Li, Z Guo, Q Wang, Y Liu, Y Bi, H Zhou, Y Wang

ACS NANO (ACS Publications) China, 03 March 2022

Oncology

Key words: Nitric oxide, Immunogenic cell death, NO nanogenerator, Vaccination effects, PD-1 blockade therapy [more]

Low miR-10b-3p associated with sorafenib resistance in hepatocellular carcinoma

YY Shao, PS Chen, LI Lin, BS Lee, A Ling, AL Cheng, C Hsu, DL Ou

British Journal of Cancer (Nature) Taiwan, USA, 02 March 2022

Oncology

Key words: Hepatocellular carcinoma, Tumour biomarkers [more]

Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

MA Shields, C Spaulding, AE Metropulos, MG Khalafalla, TND Pham, HG Munshi

Cell Reports (Cell Press) USA, 01 March 2022

Oncology

Key words: Gα13, KC mouse model, KPC mouse model, Human PDAC tumors, E-cadherin, mTOR, Rapamycin [more]

Immunoarchitectural patterns as potential prognostic factors for invasive ductal breast cancer

X Du, Z Zhou, Y Shao, K Qian, Y Wu, J Zhang, M Cui, J Wang, S Wang, Y Tai

npj Breast Cancer (Nature) China, 28 February 2022

Oncology

Key words: Breast cancer, Prognostic markers [more]

Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus

JH Lee, C Ostalecki, T Oberstein, S Schierer, E Zinser, M Eberhardt, K Blume, B Plosnita, L Stich, H Bruns, R Coras, J Vera-Gonzales, M Maler, AS Baur

EBioMedicine (Elsevier) Germany, Austria, 25 February 2022

Neuroscience

Key words: Alzheimer's disease, Plasma extracellular vesicles, Choroid plexus, Hippocampus, Hyaluronan, Hyaluronic acid synthetase, Secretases, BACE, Aβ, APP [more]

EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma

J Ingruber, J Dudás, D Savic, G Schweigl, TB Steinbichler, M do Carmo Greier, M Santer, S Carollo, Z Trajanoski, H Riechelmann

Experimental Cell Research (Elsevier) Austria, 25 February 2022

Oncology

Key words: Mesenchymal-to-epithelial transition, Cell-transfection, TissueFax, UPCI-SCC090, SCC25, FaDu [more]

Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms

X Guo, X Jin, K Han, S Kang, S Tian, X Lv, M Feng, H Zheng, Y Zuo, G Xu, M Hu, J Xu, P Lv, YZ Chang

Free Radical Biology and Medicine (Elsevier) China, 24 February 2022

Neuroscience

Key words: Iron, Ischemic stroke, Gliosis, Synaptic plasticity, Myelination, Nerve regeneration [more]

Tumor Necrosis Factor-α Mediates Lung Injury in the Early Phase of Endotoxemia

KY Chen, CY Chang, HJ Hsu, HJ Shih, IT Huang, HH Patel, CJ Huang

Pharmaceuticals (MDPI) Taiwan, Australia, 24 February 2022

Pulmonology

Key words: lung injury, endotoxin, cytokines, cytokine receptors, peptide, mice [more]

Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation

J Gao, H Mei, J Sun, H Li, Y Huang, Y Tang, L Duan, D Liu, Y Pang, Q Wang, Y Gao, K Song, J Zhao, C Zhang, J Liu

Advanced Biology (Wiley) China, Australia, 23 February 2022

SARS-CoV-2, Osteology

[more]

High farnesoid X receptor expression predicts favorable clinical outcomes in PD‑L1low/negative non‑small cell lung cancer patients receiving anti‑PD‑1‑based chemo‑immunotherapy

L Wang, X Xu, B Shang, J Sun, B Liang, X Wang, W You, S Jiang

International Journal of Oncology (Spandidos Publications) China, 23 February 2022

Oncology

Key words: Farnesoid X receptor, Predictor, anti‑PD‑1‑based, Chemo‑immunotherapy, Non‑small cell lung cancer, PD‑L1low/negative patients [more]

Prompt Antiviral Action of Pulmonary CD8+ TRM Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung

L Jiang, L Liu, M Zhang, L Zhang, C Zhu, Q He, L Ye, C Zhao, Z Li, J Xu, X Zhang

Frontiers in Immunology (Frontiers Media S.A.) China, 22 February 2022

Immunology

Key words: influenza, lung-resident memory CD8 T cells, IFN-γ, interferon-induced genes, inflammatory cytokines [more]

Meloxicam Inhibits Hepatocellular Carcinoma Progression and Enhances the Sensitivity of Immunotherapy via the MicroRNA-200/PD-L1 Pathway

S Guangshun, S Guoqiang, C Xin, K Xiangyi, Z Wubin, L Zhitao, Z Zhiying, C Hongyong, L Chengyu, X Yongxiang, T Weiwei

Journal of Oncology (Hindawi Publishing Corporation) China, 21 February 2022

Oncology

[more]

TSPAN6 is a suppressor of Ras-driven cancer

PO Humbert, TZ Pryjda, B Pranjic, A Farrell, K Fujikura, R de Matos Simoes, R Karim, I Kozieradzki, SJF Cronin, GG Neely, TF Meyer, A Hagelkruys, HE Richardson, JM Penninger

Oncogene (Nature) Australia, Austria, Germany, Canada, 19 February 2022

Oncology

Key words: Cancer genetic, Cell polarity, Growth factor signalling [more]

Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects

YH Chan, KN Ho, YC Lee, MJ Chou, WZ Lew, HM Huang, PC Lai, SW Feng

Stem Cell Research & Therapy (Springer) Taiwan, USA, 19 February 2022

Osteology

Key words: Melatonin, Dental pulp mesenchymal stem cells, Osteogenesis, COX2/NF-κB, p38/ERK signaling pathwaym, Bone regeneration, Calvarial bone defect [more]

The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

F Niu, P Han, J Zhang, Y She, L Yang, J Yu, M Zhuang, K Tang, Y Shi, B Yang, C Liu, B Peng, SJ Ji

Elife (eLife Sciences Publications) China, 18 February 2022

Neuroscience

[more]

Imaging net retrograde axonal transport in vivo: a physiological biomarker

PTJ Lee, Z Kennedy, Y Wang, Y Lu, C Cefaliello, Ö Uyan, CQ Song, BM da Cruz Godinho, Z Xu, M Rusckowski, W Xue, RH Brown

Annals of Neurology (Wiley) USA, 17 February 2022

Medical Imaging

[more]

Quantitative Characterization of Macrophage, Lymphocyte, and Neutrophil Subtypes Within the Foreign Body Granuloma of Human Mesh Explants by 5-Marker Multiplex Fluorescence Microscopy

U Klinge, A Dievernich, J Stegmaier

Frontiers in Medicine (Frontiers Media S.A.) Germany, 15 February 2022

Medical Image Analysis

Key words: Foreign body granuloma, Mesh, Multiplex, Fluorescence, Macrophage, Lymphocyte, Neutrophil [more]

Cordycerebroside A inhibits ICAM‐1‐dependent M1 monocyte adhesion to osteoarthritis synovial fibroblasts

KT Lee, CH Su, SC Liu, BC Chen, JW Chang, CH Tsai, WC Huang, CJ Hsu, WC Chen, YC Wu, CH Tang

Journal of Food Biochemistry (Wiley) Taiwan, 15 February 2022

Rheumatology

Key words: Adhesion, Cordycerebroside A, ICAM-1, M1 macrophage, Osteoarthritis [more]

A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+ CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy

D Wang, J Fang, S Wen, Q Li, J Wang, L Yang, W Dai, H Lu, J Guo, Z Shan, W Xie, X Liu, L Wen, J Shen, A Wang, Q Chen, Z Wang

International Journal of Oral Science (Nature) China, 14 February 2022

Oncology

Key words: Cancer microenvironment, Head and neck cancer [more]

Cell-Penetrating Botulinum Neurotoxin Type A With Improved Cellular Uptake and Therapeutic Index

X Wei, L Li, Y Wu, J Liu

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) China, 11 February 2022

Biological Methods, Neuroscience

Key words: Cell-penetrating peptides, Zinc finger proteins, Botulinum neurotoxin type A, Cellular uptake, Therapeutic index [more]

H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice

L Ruilian, Q Honglin, X Jun, L Jianxin, B Qingyun, C Yilin, M Haifeng

Journal of Affective Disorders (Elsevier) China, 10 February 2022

Neuroscience

Key words: Chronic stress stimulated depression model, Hippocampus, Hydrogen sulfide, Inflammatory, Aerobic exercise [more]

The effects of hypoxia on mitochondrial function and metabolism in gastric cancer cells

J Jiang, Y Jiang, YG Zhang, T Zhang, JH Li, DL Huang, J Hou, MY Tian, L Sun, XM Su, Y Dong, YY Ma

Translational Cancer Research (AME Publishing Company) China, 10 February 2022

Oncology

Key words: Gastric cancer, Hypoxia, Mitochondrial function, Aerobic respiration [more]

MYC/MAX-Activated LINC00958 Promotes Lung Adenocarcinoma by Oncogenic Transcriptional Reprogramming Through HOXA1 Activation.

T Zhang, F Su, YB Lu, XL Ling, HY Dai, TN Yang, B Zhang, D Zhao, XM Hou

Frontiers in Oncology (Frontiers Media S.A.) China, 09 February 2022

Oncology

Key words: Lung adenocarcinoma, LINC00958, MYC, MAX, Transcriptional reprogramming, HOXA1 [more]

Colonic Leucine-Rich Repeat Kinase 2 Expression Is Increased and Associated With Disease Severity in Patients With Parkinson's Disease

PH Liao, HL Chiang, CT Shun, JF Hang, HM Chiu, MS Wu, CH Lin

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 08 February 2022

Neuroscience

Key words: Parkinson’s disease, Colon biopsy, Leucine-rich repeat kinase 2, Inflammatory bowel diseases, Biomarker (BM) [more]

Differential localization and limited cytotoxic potential of duodenal CD8+ T cells

L Mvaya, T Khaba, AE Lakudzala, T Nkosi, N Jambo, I Kadwala, A Kankwatira, PD Patel, MA Gordon, TS Nyirenda, KC Jambo, ZM Ndhlovu

JCI Insight (American Society for Clinical Investigation) Malawi, South Africa, UK, USA, 08 February 2022

Immunology

[more]

Assessment of Physiological Rat Kidney Ageing—Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation

A Baumgartner, S Reichelt-Wurm, W Gronwald, C Samol, JA Schröder, C Fellner, K Holler, A Steege, FJ Putz, PJ Oefner, B Banas, MC Banas

Metabolites (MDPI) Germany, 08 February 2022

Transplantation Medicine, Nephrology

Key words: Kidney, Ageing, Transplantation, Inflammation, Urinary metabolites [more]

ATP8B1 Knockdown Activated the Choline Metabolism Pathway and Induced High-Level Intracellular REDOX Homeostasis in Lung Squamous Cell Carcinoma

X Zhang, R Zhang, P Liu, R Zhang, J Ning, Y Ye, W Yu, J Yu

Cancers (MDPI) China, 07 February 2022

Oncology

Key words: ATP8B1, LUSC, CHKA, REDOX [more]

Effect of Helicobacter pylori-associated chronic gastritis on autonomous activity and sleep quality in mice

H Liu, W Zheng, L Zhang, T Lin, Y Tang, L Hu

Frontiers in Pharmacology (Frontiers Media S.A.) China, 04 February 2022

Microbiology, Gastroenterology

Key words: Autonomous activity, Chronic gastritis, Helicobacter pylori, Mouse behavior, Sleep quality [more]

Multi-Factorial Nerve Guidance Conduit Engineering Improves Outcomes in Inflammation, Angiogenesis and Large Defect Nerve Repair

AJ Hibbitts, Z Kočí, S Kneafsey, A Matsiko, L Žilić, A Dervan, P Hinton, G Chen, B Cavanagh, JK Dowling, CE McCoy, CT Buckley, SJ Archibald, FJ O'Brien

Matrix Biology (Elsevier) Ireland, USA, 04 February 2022

Neuroscience

Key words: Peripheral Nerve, Biomaterials, Extracellular Matrix, Nerve Guidance Conduit, Angiogenesis, Inflammation [more]

Tegaserod Maleate Inhibits Breast Cancer Progression and Enhances the Sensitivity of Immunotherapy

X Li, L Wu, Z Zheng, H Liu, H Li, G Sun, G Sun, Y Cheng, H Wang, Z Li, J Shi, W Tang

Journal of Oncology (Hindawi Publishing Corporation) China, Germany, 03 February 2022

Oncology, Pharmacology

[more]

Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR) USA, 02 February 2022

Oncology, Immunology

[more]

Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues

M Tsuda, R Horio, L Wang, T Takenami, J Moriya, J Suzuka, H Sugino, Z Tanei, M Tanino, S Tanaka

Scientific Reports (Nature) Japan, 02 February 2022

Biological Methods

Key words: Assay systems, Biotechnology [more]

Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond

S Chen, W Li, X Zheng, P Yu, P Wang, Z Sun, Y Xu, D Jiao, X Ye, M Cai, M Shen, M Wang, Q Zhang, F Kong, Y Wang, J He, H Wei, F Shi, J Du

PNAS (United States National Academy of Sciences) China, 01 February 2022

Oncology

Key words: Tumor Tissue, Histological Magnetometry, Nitrogen-Vacancy Center, Micrometer-Resolution Magnetic Imaging, Absolute Magnetic Quantification [more]

PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through β-catenin dysregulation

BY Ahn, MH Jeong, JH Pyun, HJ Jeong, TA Vuong, JH Bae, S An, SW Kim, YK Kim, D Ryu, HJ Kim, H Cho, GU Bae, JS Kang

Cellular and Molecular Life Sciences (Springer) South Korea, 28 January 2022

Cardiology

Key words: PRMT7, Cardiomyopathy, Wnt, β-catenin [more]

Regorafenib enhances antitumor immune efficacy of anti-PD-L1 immunotherapy on oral squamous cell carcinoma

IT Chiang, YH Lee, ZL Tan, FT Hsu, HF Tu

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 26 January 2022

Oncology, Pharmacology

Key words: Oral squamous cells carcinoma, Regorafenib, Anti-PD-L1, Antitumor-induced immunity [more]

Metastatic Tumor Antigen 1 Contributes to Hepatocarcinogenesis Posttranscriptionally Through Novel RNA Binding Function

YT Li, CJ Liu, JH Kao, LF Lin, HC Tu, CC Wang, PH Huang, HR Cheng, PJ Chen, DS Chen, HL Wu

Hepatology (Wiley) Taiwan, 24 January 2022

Oncology

Key words: RNA stability, Post-transcriptional control, Tumorigenic capacity, Self-renewal and anchorage-independent growth, Carcinogenesis [more]

Inhibition of β-catenin signaling attenuates arteriovenous fistula thickening in mice by suppressing myofibroblasts

CT Liu, SC Hsu, HL Hsieh, CH Chen, CY Chen, YM Sue, TH Chen, YH Hsu, FY Lin, CM Shih, YT Shiu, PH Huang

Molecular Medicine (BMC) Taiwan, USA, 21 January 2022

Nephrology

Key words: Arteriovenous fistula (AVF), β-catenin, Hemodialysis, Myofibroblast [more]

Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT

N Kane, T Romero, S Diaz-Perez, MB Rettig, ML Steinberg, AU Kishan, D Schaue, RE Reiter, BS Knudsen, NG Nickols

Prostate Cancer and Prostatic Diseases (Nature) USA, 20 January 2022

Oncology

Key words: Cancer therapy, Prostate cancer [more]

Chidamide and mitomycin C exert synergistic cytotoxic effects against bladder cancer cells in vitro and suppress tumor growth in a rat bladder cancer model

SC Wang, CY Yu, YC Wu, YC Chang, SL Chen, WW Sung

Cancer Letters (Elsevier) Taiwan, 18 January 2022

Oncology

Key words: Urothelial carcinoma, Histone, N-methyl-N-nitrosourea, Deacetylase, Axl [more]

Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response

AM Gamage, KS Tan, WOY Chan, ZZR Lew, J Liu, CW Tan, D Rajagopalan, QXX Lin, LM Tan, PN Venkatesh, YW Ong, M Thong, RTP Lin, S Prabhakar, DY Wang, LF Wang

mBio (American Society for Microbiology) Singapore, 18 January 2022

SARS-CoV-2, Immunology

[more]

Repair phase modeling of ischemic acute kidney injury: recovery vs. transition to chronic kidney disease

K Lee, HR Jang, J Jeon, KE Yang, JE Lee, GY Kwon, DJ Kim, W Huh

American Journal of Translational Research (e-Century Publishing Corporation) South Korea, 15 January 2022

Nephrology

Key words: Ischemic acute kidney injury, Chronic kidney disease, Ischemia-reperfusion injury, Recovery, Repair [more]

Cottonseed protein concentrate as fishmeal alternative for largemouth bass (Micropterus salmoides) supplemented a yeast-based paraprobiotic: Effects on growth performance, gut health and microbiome

X Xie, J Wang, Y Guan, S Xing, X Liang, M Xue, J Wang, Y Chang, E Leclercq

Aquaculture (Elsevier) China, France, 13 January 2022

Zoology

Key words: Cottonseed Protein Concentrate, Largemouth Bass, Paraprobiotic, Gut Health, Gut Microbiome [more]

P2RX7 in dopaminergic neurons of ventral periaqueductal gray mediates HTWP acupuncture-induced consciousness in traumatic brain injury

H Tang, S Qin, W Li, X Chen, L Ulloa, Q Zhu, B Liu, Y Gong, Y Zhao, S Wang, S Li, Y Guo, Z Xu, Y Guo

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China, USA, 13 January 2022

Neuroscience

Key words: Acupuncture, Traumatic Brain Injury, Neural Projection, Dopamine, P2RX7, Ventral Periaqueductal Gray, Hand 12 Jing-Well Points [more]

Autochthonous Human Dirofilaria repens Infection in Austria

N Geissler, J Ruff, J Walochnik, W Ludwig, H Auer, U Wiedermann, W Geissler

Acta Parasitologica (Springer) Austria, 12 January 2022

Parasitology

Key words: Dirofilariasis · Nematode infections · Parasitic worms · Climate change · Austria [more]

Large deletion of Wdr19 in developing renal tubules disrupts primary ciliogenesis leading to polycystic kidney disease in mice

SS Yu, E Wang, CY Chiang, PH Cheng, YS Yeh, YY Wu, YY Chiou, ST Jiang

The Journal of Pathology (Wiley) Taiwan, 10 January 2022

Nephrology

Key words: Wdr19, intraflagellar transport, primary cilia, renal cyst, polycystic kidney disease [more]

Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease

HC Campos, DE Ribeiro, D Hashiguchi, DY Hukuda, C Gimenes, SAA Romariz, Q Ye, Y Tang, H Ulrich, B Monteiro Longo

Stem Cell Reviews and Reports (Springer) Brazil, China, 08 January 2022

Neuroscience, Stem Cell Research

Key words: Alzheimer’s Disease, Hippocampus, Neural and Mesenchymal Stem Cell Transplantation, Tissue Cytometry, Amyloid-β plaques [more]

Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin

W Vankrunkelsven, S Derde, J Gunst, S Vander Perre, E Declerck, L Pauwels, I Derese, G Van den Berghe, L Langouche

Journal of Cachexia, Sarcopenia and Muscle (Wiley) Belgium, 07 January 2022

Infectious Diseases, Endocrinology

Key words: Leptin, Critical Illness, Sepsis, Muscle Weakness, Intensive Care Unit Acquired Weakness, Atrophy, Protein Catabolism [more]

Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection

FJ Ogunshola, W Smidt, AF Naidoo, TP Nkosi, T Ngubane, PT Khaba, OO Baiyegunhi, B Mahlobo, S Rasehlo, N Ngema, I Jajbhay, KL Dong, V Ramsuran, J Pansegrouw, T Ndung'u, B Walker, T de Oliveria, ZM Ndhlovu

Blood Advances (ASH Publications) South Africa, USA, Germany, 06 January 2022

Immunology

Key words: Immunobiology, Immunotherapy [more]

Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity

H Wang, Y Fan, W Chen, Z Lv, S Wu, Y Xuan, Chenfeng Wang, Yongliang Lu,Tao Guo,Donglai Shen,Fan Zhang,Qingbo Huang,Yu Gao,Hongzhao Li,Xin Ma,Baojun Wang,Yan Huang &Xu Zhang

OncoImmunology (Taylor & Francis) China, 05 January 2022

Oncology

Key words: CMTM6, DNA Damage, Cellular Senescence, Immunity, Renal Cell Carcinoma [more]

SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages

Z Wang, J Lv, P Yu, Y Qu, Y Zhou, L Zhou, Q Zhu, S Li, J Song, W Deng, R Gao, Y Liu, J Liu, WM Tong, C Qin, B Huang

Cellular & molecular Immunology (Nature) China, 04 January 2022

SARS-CoV-2, Immunology

Key words: SARS-CoV-2, Microparticles, Alveolar Macrophages, Endosomes, Lysosomes [more]

Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes

CL Ho, LLH Huang, SJ Shieh

Regenerative Biomaterials (Chinese Society for Biomaterials) Taiwan, 04 January 2022

Stem Cell Research

Key words: Chondrocytes, Cell Proliferation, Perichondrial Progenitor Cells, Paracrine Effect, Neocartilage Formation [more]

Stabilization but no functional influence of HIF-1α expression in the intestinal epithelium during Salmonella Typhimurium infection

L Robrahn, A Dupont, S Jumpertz, K Zhang, CH Holland, J Guillaume, S rappold, J Roth, V Cerovic, J Saez-Rodriguez, MW Hornef, T Cramer

Infection and Immunity (American Society for Microbiology) Germany, The Netherlands, 03 January 2022

Immunology, Microbiology

[more]

Preclinical Safety of a 3D-Printed Hydroxyapatite-Demineralized Bone Matrix Scaffold for Spinal Fusion

M Plantz, J Lyons, JT Yamaguchi, AC Greene, DJ Ellenbogen, MJ Hallman, V Shah, C Yun, AE Jakus, D Procissi, S Minardi, RN Shah, WK Hsu, EL Hsu

Spine (ingentaconnect) USA, 01 January 2022

Osteology

Key words: 3D Printing, Bone Morphogenetic Protein-2, Demineralized Bone Matrix, Host Inflammatory Response, Hydroxyapatite, Spinal Fusion [more]

Detection of Cytopathic Effects Induced by Influenza, Parainfluenza, and Enterovirus Using Deep Convolution Neural Network

JJ Chen, PH Lin, YY Lin, KY Pu, CF Wang, SY Lin, TS Chen

Biomedicines (MDPI) Taiwan, 28 December 2021

Machine Learning, Virology

Key words: Artificial Intelligence, Cytopathic Effect, ResNet-50

The liquid Kangfuxin (KFX) has efficient antifungal activity and can be used in the treatment of vulvovaginal candidiasis in mouse

J Ma, YC Yang, LQ Su, DM Qin, K Yuan, Y Zhang, RR Wang

Letters in Applied Microbiology (Wiley) China, 27 December 2021

Infectious Diseases, Reproductive Medicine

Key words: Candida Albicans, Kangfuxin Liquid, Antifungal, Vaginal Candidiasis, Murine Model [more]

Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

CY Chang, KY Chen, HJ Shih, M Chiang, IT Huang, YH Huang, CJ Huang

Pharmaceuticals (MDPI) Taiwan, 27 December 2021

Endocrinology

Key words: Obesity, Sepsis, Liver, Exosomes, let-7i [more]

Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis

J Zhang, L Wang, C Li, H Zhang, R Li, M Li

Systems biology in Reproductive Medicine (Taylor & Francis) China, 27 December 2021

Reproductive Medicine

Key words: Letrozole, Endometriosis, Endometrial Receptivity, Integrin avβ3, HOXA10 [more]

Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells

K Piatek, A Kutner, D Cacsire Castillo-Tong, T Manhardt, N Kupper, U Nowak, M Chodyński, E Marcinkowska, E Kallay, M Schepelmann

International Journal of Molecular Sciences (MDPI) Austria, Poland, 24 December 2021

Endocrinology, Oncology

Key words: Vitamin D, Vitamin D Analogs, 25 Vitamin D 24-Hydroxylase, CYP24A1, Proliferation, High-Grade Serous Ovarian Cancer Cells [more]

Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression

YH Chu, WC Liao, YJ Ho, CH Huang, TJ Tseng, CH Liu

Cells (MDPI) Taiwan, 20 December 2021

Oncology

Key words: Glioma, Chondroitin Sulfate, CHSY1, Integrin Β1, CD44, Therapeutic Peptide

S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 …

K Tanigawa, S Tsukamoto, Y Koma, Y Kitamura, S Urakami, M Shimizu, M Fujikawa, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki

The American Journal of Pathology (Elsevier) Japan, 20 December 2021

Oncology

[more]

P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease

Y Li, H Zhang, J Yang, M Zhan, X Hu, Y Liu, L Yu, X Yan, S Liang, R Zhang, Y Lu, B Li, C Liu, M Li

Chinese Medicine (Springer) China, 16 December 2021

Gastroenterology

Key words: P2Y12 Receptor, Visceral Pain, Depression, EA, IBD [more]

Spatial point pattern analysis identifies mechanisms shaping the skin parasite landscape in Leishmania donovani infection

JSP Doehl, H Ashwin, N Brown, A Romano, S Carmichael, JW Pitchford, PM Kaye

Frontiers in Immunology (Frontiers Media S.A.) UK, 16 December 2021

Parasitology

Key words: Leishmania donovani, host cell, dispersion, dispersal, skin patches, spatial point pattern analysis [more]

Hedgehog-signalling in papillary fibroblasts is essential for hair follicle regeneration during wound healing

S Frech, A Forsthuber, A Korosec, K Lipp, V Kozumov, BM Lichtenberger

Journal of Investigative Dermatology (Elsevier) Austria, 16 December 2021

Dermatology

Key words: Wound Healing, Dermal Fibroblast Lineages, Hedgehog Signaling, Hair Follicle Neogenesis, WIHN, Papillary and Reticular Fibroblasts, Regeneration [more]

CD163+ M2 macrophages promote fibrosis in IgG4‐related disease via TLR7/IRAK4/NF‐κB signaling

A Chinju, M Moriyama, N Kakizoe-Ishiguro, H Chen ,Y Miyahara, AR Haque, K Furusho, M Sakamoto, K Kai, K Kibe, S Hatakeyama-Furukawa, M Ito-Ohta, T Maehara, S Nakamura

Arthritis & Rheumatology (Wiley) Japan, Bangladesh, 15 December 2021

Immunology, Rheumatology

Key words: Igg4-Related Disease, M2 Macrophage, Toll-Like Receptor 7, IL-1 Receptor-Associated Kinase 4, Fibrosis [more]

Nuplazid suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting PAK4

Y Wei, W Wu, Y Jiang, H Zhou, Y Yu, L Zhao, X Wu, X Lu, Q Yuan, Z Wang, Z Dong, L He, J Zhao, K Liu

British Journal of Cancer (Nature) China, 15 December 2021

Oncology

Key words: Cancer Prevention [more]

Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma

C Wang, Y Huang, X Ma, B Wang, X Zhang

International Journal of Immunpathology and Pharmacology (SAGE Journals) China, 15 December 2021

Oncology

Key words: Clear Cell Renal Cell Carcinoma, NEK2, Prognosis [more]

A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice

K Cao, X Wang, H Peng, L Ding, X Wang, Y Hu, L Dong, T Yang, X Hong, M Xing, D Li, C Zhu, X He, C Zhao, P Zhao, D Zhou, X Zhang, J Xu

Journal of Virology (American Society for Microbiology) China, 15 December 2021

SARS-CoV-2

Key words: COVID-19, Vaccine, SARS-CoV-2 Variants, Influenza, Adenoviral Vector [more]

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development

T Wang, J Zhang, N Li, M Li, S Ma, S Tan, X Guo, Z Wang, Z Wu, L Gao, C Ma, X Liang

Molecular Therapy (Cell Press) China, 15 December 2021

Oncology

Key words: Tim-3, Tim-3 Ligands, Immune Checkpoint Blockade, Tumor Microenvironment, Multiplexed Immunofluorescence [more]

Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response

YT Yen, M Chien, PY Wu, CC Ho, CT Ho, KCY Huang, SF Chiang, KSC Chau, WTL Chen, SC Hung

Nature Communications (Nature) Taiwan, 15 December 2021

Oncology, Immunology

Key words: Cancer Immunotherapy, Colon Cancer, Gene Silencing, Immunoediting [more]

Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

J Chen, J Fan, Z Chen, M Zhang, H Peng, J Liu, L Ding, M Liu, C Zhao, P Zhao, S Zhang, X Zhang, J Xu

PNAS (United States National Academy of Sciences) China, 14 December 2021

SARS-CoV-2

[more]

Polypharmacological reprogramming of tumor-associated macrophages towards an inflammatory phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR) USA, 13 December 2021

Oncology

Key words: Tumor-Associated Macrophage, Breast Cancer, Tumor Microenvironment, Kinase Inhibitor Screening, Cell-Cell Interaction [more]

The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model

A Kannan, S Minardi, DJ Ellenbogen, MJ Hallman, AC Greene, JT Yamaguchi, MA Plantz, S Jeong, KC Sana, V Shah, C Yun, EL Hsu, WK Hsu

JOR Spine (Wiley) USA, 13 December 2021

Rheumatology

Key words: Local Steroid, Osteogenesis, Pseudarthrosis, Spine Fusion [more]

The plasminogen receptor Plg‐RKT regulates adipose function and metabolic homeostasis

F Samad, H Bai, N Baik, P Haider, Y Zhang, G Rega-Kaun, C Kaun, M Prager, J Wojta, Q Bui, S Chakrabarty, J Wang, RJ Parmer, LA Miles

Journal of Thrombosis and Haemostasis (Wiley) USA, Austria, 12 December 2021

Endocrinology

Key words: Adipose Inflammation, Hepatic Steatosis, Insulin Resistance, Obesity, Plg-RKT [more]

Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension

Z Zhao, Z Guo, Z Yin, Y Qiu, B Zhou

Frontiers in Physiology (Frontiers Media S.A.) China, 10 December 2021

Gastroenterology

Key words: Intra-Abdominal Hypertension, Abdominal Compartment Syndrome, Fecal Microbiota Transplantation, 16S rRNA, Gut Microbiota Dysbiosis [more]

FGL1 as a Novel Mediator and Biomarker of Malignant Progression in Clear Cell Renal Cell Carcinoma.

Z Lv, B Cui, X Huang, HY Feng, T Wang, HF Wang, YD Xuan, HZ Li, X Ma, Y Huang, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 09 December 2021

Oncology

Key words: biomarker, clear cell renal cell carcinoma, epithelial to mesenchymal transition, fibrinogen-like protein 1, progression [more]

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

T Zhang, L Sun, Y Hao, C Suo, S Shen, H Wei, W Ma, P Zhang, T Wang, X Gu, ST Li, Z Chen, R Yan, Y Zhang, Y Cai, R Zhou, W Jia, F Huang, P Gao, H Zhang

Nature Cancer (Nature) China, 09 December 2021

Oncology

[more]

CD146 as a Prognostic-Related Biomarker in ccRCC Correlating With Immune Infiltrates

Z Lv, HY Feng, W Tao, HZ Li, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 08 December 2021

Oncology

Key words: CD146, ccRCC, prognosis, methylation, tumor microenvironment [more]

Lipid Droplet-Specific Probe for Rapidly Locating Atherosclerotic Plaques and Intraoperative Imaging via In Situ Spraying

M Sang, B Cai, S Qin, S Zhao, Y Mao, Y Wang, X Yu, J Zheng

ACS Applied Materials & Interfaces (ACS Publications) China, 06 December 2021

Biological Methods

Key words: Lipids, Liquids, Fluorescence, Fluorescence Imaging, Probes [more]

Ascorbic acid-2 glucoside mitigates intestinal damage during pelvic radiotherapy in a rat bladder tumor model

Y Ito, T Yamamoto, K Miyai, J Take, H Scherthan, A Rommel, S Eder, K Steinestel, A Rump, M Port, N Shinomiya, M Kinoshita

International Journal of Radiation Biology (Taylor & Francis) Japan, Germany, 06 December 2021

Oncology, Radiotherapy

Key words: AY-27 Cells, DNA Damage, 53BP1, CD163, M1/M2, Macrophages [more]

Hedgehog signaling controls bone homeostasis by regulating osteogenic/adipogenic fate of skeletal stem/progenitor cells in mice

L Zhang, X Fu, L Ni, C Liu, Y Zheng, H You, M Li, C Xiu, L Zhang, T Gong, N Luo, Z Zhang, G He, S Hu, H Yang, D Chen, J Chen

Journal of Bone and Mineral Research (Wiley) China, 06 December 2021

Osteology, Stem Cell Research

Key words: Genetic Animal Models, Hedgehogs, Stromal/Stem Cells, Osteoporosis, Aging [more]

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

JL Zhang, YH Li, LL Wang, HQ Liu, SY Lu, Y Liu, K Li, B Liu, SY Li, FM Shao, K Wang, N Sheng, R Li, JJ Cui, PC Sun, CX Ma, B Zhu, Z Wang, YH Wan, SS Yu, Y Che, CY Wang, C Wang, Q Zhang, LM Zhao, XZ Peng, Z Cheng, JB Chang, JD Jiang

Signal Transduction and Targeted Therapy (Nature) China, 06 December 2021

SARS-CoV-2

Key words: Drug Development, Infectious Diseases [more]

Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration

M Zou, L Gong, Q Ke, R Qi, X Zhu, W Liu, Q Sun, X Tang, Z Luo, X Gong, Y Liu, DWC Li

Free Radical Biology and Medicine (Elsevier) China, 04 December 2021

Cell Biology

Key words: Age-Related Macular Degeneration, Heterochromatin, Inflammation, Methotrexate, cGAS, STING [more]

Defect of LSS Disrupts Lens Development in Cataractogenesis.

M Zhao, T Mei, B Shang, B Zou, Q Lian, W Xu, K Wu, Y Lai, C Liu, L Wei, J Zhu, K Zhang, Y Liu, L Zhao

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 02 December 2021

Developmental Biology

Key words: lanosterol synthase, congenital cataract, mouse model, mutation, lens development [more]

Mad2 Induced Aneuploidy Contributes to Eml4-Alk Driven Lung Cancer by Generating an Immunosuppressive Environment

K Alikhanyan, Y Chen, K Somogyi, S Kraut, R Sotillo

Cancers (MDPI) Germany, 30 November 2021

Oncology

Key words: Lung Cancer, Aneuploidy, Tumor Microenvironment, Immune Suppression, Mouse Models [more]

Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1

A Lo, K Holmes, S Kamlapurkar, F Mundt, S Moorthi, I Fung, S Fereshetian, J Watson, SA Carr, P Mertins, AH Berger

Science Signaling (Science) USA, 30 November 2021

Oncology

[more]

Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy

A Dodd, AA Natfji, A Evangelinos, A Grigoletto, G Pasut, F Beards, L Renshall, HMI Osborn, F Greco, LK Harris

Molecular Pharmaceutics (ACS Publications) UK, Italy, 29 November 2021

Pharmacology

Key words: Polymer−Drug Conjugate PEG Pregnancy Placenta Transport Drug Delivery [more]

ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

VA Arrieta, AX Chen, JR Kane, SJ Kang, C Kassab, C Dmello, J Zhao, KB Burdett, PS Upadhyayula, C Lee-Chang, J Shilati, D Jaishankar, L Chen, A Gould, D Zhang, J Yuan, W Zhao, X Ling, JK Burks, B Laffleur, C Amidei, JN Bruce, RV Lukas, JT Yamaguchi, D Cieremans, G Rothschild, U Basu, M McCord, DJ Brat, H Zhang, LAD Cooper, B Zhang, P Sims, TF Cloughesy, R Prins, P Canoll, R Stupp, AB Heimberger, C Horbinski, FM Iwamoto, R Rabadan, AM Sonabend

Nature Cancer (Nature) USA, Mexico, France, 29 November 2021

Oncology

Key words: Cancer, Cancer Immunotherapy, CNS Cancer, Tumour Biomarkers [more]

Single cell imaging-based chromatin biomarkers for tumor progression

S Venkatachalapathy, DS Jokhun, M Andhari, GV Shivashankar

Scientific Reports (Nature) Singapore, India, Italy, Switzerland, 29 November 2021

Oncology

Key words: Biomarkers, Biophysics, Cancer, Computational Biology and Bioinformatics [more]

Lipid‐Activatable Fluorescent Probe for Intraoperative Imaging of Atherosclerotic Plaque Using In Situ Patch

J Zheng, S Zhao, Y Mao, Z Du, G Li, M Sang

Nano Micro Small (Wiley) China, 27 November 2021

Biological Methods

[more]

HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

C Da, J Pu, Z Liu, J Wei, Y Qu, Y Wu, B Shi, J Yang, N He, P Hou

Signal Transduction and Targeted Therapy (Nature) China, 24 November 2021

Oncology

Key words: Cancer, Molecular Biology [more]

Mechanism of Chronic Stress-Induced Glutamatergic Neuronal Damage in the Basolateral Amygdaloid Nucleus

S Wang, X Liu, W Shi, Q Qi, G Zhang, Y Li, B Cong, M Zuo

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 23 November 2021

Neuroscience

[more]

Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

C Wang, A Cui, M Bukenya, A Aung, D Pradhan, CA Whittaker, Y Agarwal, A Thomas, S Liang, P Amlashi, H Suh, S Spranger, N Hacohen, DJ Irvine

Cell Reports (Cell Press) USA, 23 November 2021

Immunology, Oncology

Key words: NK Cell, Macrophage, Checkpoint Blockade, Sensitization, Tumor-Targeting Antibody, Interleukin-2, Tumor Microenvironment, Vascular Normalization [more]

Pectins from various sources inhibit galectin-3-related cardiac fibrosis

AR van der Velde, WC Meijers, HHW Silljé, P Muntendam, MM Dokter, WH van Gilst, HA Schols, RA de Boer

Current Research in Translational Medicine (Elsevier) USA, The Netherlands, 23 November 2021

Cardiology

Key words: Galectin-3, Inhibitor, Pectin, Heart failure, Fibrosis, Affinity [more]

Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds

WH Tsai, CH Chou, TY Huang, HL Wang, PJ Chien, WW Chang, HT Lee

Cells (MDPI) Taiwan, 22 November 2021

Dermatology

Key words: Heat-Killed Probiotics, Lactobacillus, L. Plantarum, L. Paracasei, Skin Wound Healing, Lipoteichoic Acid [more]

Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin-and mucosa-resident memory T cells

S Saluzzo, RV Pandey, LM Gail, R Dingelmaier-Hovorka, L Kleissl, L Shaw, B Reininger, D Atzmüller, J Strobl, V Tonzeau-Römer, A Beer, C Staud, A Rieger, M Farlik, W Weninger, G Stingl, G Stary

Immunity (Cell Press) Austria, 22 November 2021

Immunology, Virology

Key words: HIV, Tissue-Resident Memory T Cells, Skin, Mucosal Immunity, HPV, Cancer, CXCR3 [more]

CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c. 1085 Genotypes

YM Yeh, PC Lin, WC Su, MR Shen

International Journal of Molecular Sciences (MDPI) Taiwan, 22 November 2021

Oncology

Key words: Colony-Stimulating Factor 1 Receptor, Genetic Variant, CD40, IL-2 Expression, Colorectal Cancer [more]

BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression

Q Wu, F Liu, M Ge, KV Laster, L Wei, R Du, M Jiang, J Zhang, Y Zhi, G Jin, S Zhao, DJ Kim, Z Dong, K Liu

Oncogene (Nature) China, 19 November 2021

Oncology

Key words: Oncogenes, Transcription [more]

Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca2+ …

R Wang, M Wang, B Liu, H Xu, J Ye, X Sun, G Sun

Biomedicine & Pharmacotherapy (Elsevier) China, 17 November 2021

Cardiology

Key words: calenduloside E, myocardial ischemia-reperfusion injury, L-type Ca2+ channels, BAG3, calcium overload, autophagy [more]

Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy

M Gao, Y Chen, C Wu

Bioengineered (Taylor & Francis) China, 16 November 2021

Nanomedicine, Oncology

Key words: Malignant Glioma, Doxorubicin-Loaded Nanoparticles, Chemosensitization, Tumor Chemotherapy, Size-Dependent [more]

Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells

KC Wei, YC Lin, CH Chen, YH Chu, CY Huang, WC Liao, CH Liu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, 15 November 2021

Oncology

Key words: Fucosyltransferase 8, Glioma, HGF, MET, EGFR [more]

HSBP1 Is a Novel Interactor of FIP200 and ATG13 That Promotes Autophagy Initiation and Picornavirus Replication

M Mauthe, N Dinesh Kumar, P Verlhac, N van de Beek, F Reggiori

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) The Netherlands, 15 November 2021

Virology

Key words: Autophagy, Infection, ULK Kinase Complex, EMCV, CVB3, EV71 [more]

Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

LC Wang, WY Wei, PC Ho, PY Wu, YP Chu, KJ Tsai

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 12 November 2021

Neuroscience

Key words: Cortical Electrical Stimulation, Neuromodulation, Ischemic Stroke, BDNF, PI3K – PKB/Akt Signaling Pathway [more]

TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma

EY Lee, M Kim, BK Choi, DH Kim, I Choi, HJ You

Molecules and Cells (Korean Society for Molecular and Cellular Biology) South Korea, 12 November 2021

Oncology

Key words: cytokines, leiomyosarcoma, tjp1, tumor microenvironment [more]

Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

AE Hinman, C Jani, SC Pringle, WR Zhang, N Jain, AJ Martinot, AK Barczak

eLife (eLife Sciences Publications) USA, 10 November 2021

Immunology, Microbiology

[more]

Dopamine D2 receptor regulates cortical synaptic pruning in rodents

YQ Zhang, WP Lin, LP Huang, B Zhao, CC Zhang, DM Yin

Nature Communications (Nature) China, 08 November 2021

Neuroscience

Key words: Diseases of The Nervous System, Molecular Neuroscience, Spine Regulation and Structure, Synaptic Development [more]

Donor Bone Marrow Derived Macrophage Engraftment into the Central Nervous System of Allogeneic Transplant Patients

AM Loeb, SS Pattwell, A Bedalov, S Meshinchi, KR Loeb

Blood (ASH Publications) USA, 05 November 2021

Hematology

[more]

IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1

WJ Wu, SH Wang, CC Wu, YA Su, CY Chiang, CH Lai, TH Wang, TL Cheng, JY Kuo, TC Hsu, TH Lin, YJ Lee

International Journal of Molecular Sciences (MDPI) Taiwan, 05 November 2021

Reproductive Medicine

Key words: IL-4, IL-13, Mammary Glands, Cell Proliferation, STAT6, IRS Protein [more]

Cholesterol-lowering Intervention Decreases mTOR Complex 2 Signaling and Enhanced Antitumor Immunity

Y Wang, S You, S Su, A Yeon, E Lo, S Kim, J Mohler, MR Freeman, HL Kim

Clinical Cancer Research (AACR) USA, 02 November 2021

Oncology

[more]

Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

RJ Ni, YM Shu, T Li, JN Zhou

Frontiers in Neuroanatomy (Frontiers Media S.A.) China, 02 November 2021

Neuroscience

Key words: Caudate Nucleus, Putamen, Accumbens Nucleus, Thalamus, Neural Circuits [more]

Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals

S Fischer, E Nasyrov, M Brosien, KT Preissner, HM Marti, R Kunze

Journal of Neuroinflammation (BMC) Germany, 02 November 2021

Neuroscience

Key words: Extracellular RNA, Astrocyte, Inflammation, Stroke, Ischemia/Reperfusion, PAMP, DAMP, TLR [more]

Expression of Vascular Cell Adhesion Molecule-1 in Peripheral Artery Disease is Enriched in Patients with Advanced Kidney Disease

PT Lee, IC Liao, CH Lee, LW Hsu, PY Liu

Acta Cardiologica Sinica (Taiwan Society of Cardiology) Taiwan, 01 November 2021

Cardiology

Key words: Chronic Kidney Disease, Hemodialysis [more]

SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway

CY Kuo, YC Chang, MN Chien,

Endocrine-Related Cancer (Society for Endocrinology) Taiwan, 01 November 2021

Oncology

Key words: SREBP1, Invasion, Thyroid Cancer, Lipid Metabolism [more]

SPION NANOPARTICLES IN VITRO AND IN VIVOTESTING FOR ANTIMELANOMA DRUG RELEASE INTO TUMORS

M Doni, HF Oancea, HRC Fierăscu

The International Symposium PRIOrities of CHEMistry for a sustainable development (ICECHIM) Romania, 29 October 2021

Oncology, Nanomedicine

Key words: melanoma cells, syngeneic melanoma mouse model, drug delivery, IHC, RT-qPCR [more]

Spatiotemporal Protein Expression Profiles of QSOX1 in the Murine Uterus, Placenta, and Embryo during Pregnancy

HS Lin, RKK Lee, TH Yang, HW Fang, SH Li

Applied Sciences (MDPI) Taiwan, 29 October 2021

Reproductive Medicine

Key words: Quiescin Sulfhydryl Oxidase 1, Uterus, Placenta, Embryo, Maternal-Fetal Interface, Tissue Distribution, Pregnancy [more]

Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer

BL Horton, DM Morgan, N Momin, M Zagorulya, E Torres-Mejia, V Bhandarkar, KD Wittrup, JC Love, S Spranger

Science Immunology (Science) USA, 29 October 2021

Oncology, Immunology

[more]

Carboxypeptidase N1 is anticipated to be a synergy metrics for chemotherapy effectiveness and prognostic significance in invasive breast cancer

YY Fan, CH Liu, AL Wu, HC Chen, YJ Hsueh, KJ Chen, CC Lai, CY Huang, WC Wu

Cancer Cell International (Springer) China, 28 October 2021

Oncology

Key words: Carboxypeptidase N1, CA153, Chemotherapeutic Efficacy, Prognosis, Invasive Breast Cancer [more]

Increased osteogenic activity of dynamic cultured composite bone scaffolds: Characterization and in vitro study

ML Mueller, MP Ottensmeyer, JR Thamm, R Schmelzeisen, MJ Troulis, FPS Guastaldi

Journal of Oral and Maxillofacial Surgery (Elsevier) USA, Germany, 27 October 2021

Osteology

Key words: Scaffolds, Bone Tissue Engineering, Calcium Phosphate, 3D Printing, ALP [more]

Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer

PF Yueh, YH Lee, I Chiang, WT Chen, KL Lan, CH Chen, FT Hsu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, USA, 26 October 2021

Oncology

Key words: Imipramine, Non-Small Cell Lung Cancer (NSCLC), EGFR - Epidermal Growth Factor Receptor, PKC-δ-Protein Kinase C Delta, NF-κB – Nuclear Factor Kappa B [more]

The prognostic value of TCF1+ CD8+ T in primary small cell carcinoma of the esophagus

L Ma, L Sun, K Zhao, Z Dong, Z Huang, X Meng

Cancer Science (Japanese Cancer Association) China, 25 October 2021

Oncology

Key words: prognosis, PSCCE, stem‐like, TCF1, tumor microenvironment [more]

Metabolic memory underlying minimal residual disease in breast cancer

K Radic Shechter, E Kafkia, K Zirngibl, S Gawrzak, A Alladin, D Machado, C Lüchtenborg, DC Sevin, B Brügger, KR Patil, M Jechlinger

Molecular Systems Biology (EMBO press) Germany, UK, 25 October 2021

Oncology

[more]

Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction

LJ Renshall, F Beards, A Evangelinos, SL Greenwood, P Brownbill, A Stevens, CP Sibley, JD Aplin, ED Johnstone, T Teesalu, LK Harris

Pharmaceutics (MDPI) UK, USA, 25 October 2021

Reproductive Medicine

Key words: Placenta, Pregnancy, Fetal Growth Restriction, LLiposomes, Epidermal Growth Factor [more]

Cardiac Fibrosis Is a Risk Factor for Severe COVID-19

J Mustroph, J Hupf, MJ Baier, K Evert, C Brochhausen, K Broeker, C Meindl, B Seither, C Jungbauer, M Evert, LS Maier, S Wagner

Frontiers in Immunology (Frontiers Media S.A.) Germany, 22 October 2021

SARS-CoV-2

Key words: SARS-CoV-2, COVID-19, Fibrosis, Heart, TGF-β1, NRP-1 [more]

Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist

H Mei, Z Zha, W Wang, Y Xie, Y Huang, W Li, D Wei, X Zhang, J Qu, J Liu

Genome Biology (BMC) China, 22 October 2021

Genetics

Key words: CRISPR, Genome-wide screen, Surfaceome screen, Rhinovirus, OLFML3 [more]

Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

C Shen, R Li, R Negro, J Cheng, SM Vora, TM Fu, A Wang, K He, L Andreeva, P Gao, Z Tian, RA Flavell, S Zhu, H Wu

CELL (Cell Press) USA, China, Italy, 21 October 2021

Immunology, Virology

Key words: NLRP6, dsRNA, Liquid-Liquid Phase Separation, LLPS, Inflammasome, MHV, RV, IDRs [more]

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

C Vinel, G Rosser, L Guglielmi, M Constantinou, N Pomella, X Zhang, JR Boot, TA Jones, TO Millner, AA Dumas, V Rakyan, J Rees, JL Thompson, J Vuononvirta, S Nadkarni, TE Assan, N Aley, YY Lin, P Liu, S Nelander, D Sheer, CLR Merry F Marelli-Berg, S Brandner, S Marino

Nature Communications (Nature) UK, Hong Kong, Sweden, 21 October 2021

Oncology

Key words: CNS Cancer, Reprogramming [more]

KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements

SM Zhang, WL Cai, X Liu, D Thakral, J Luo, LH Chan, MK McGeary, E Song, KRM Blenman, G Micevic, S Jessel, Y Zhang, M Yin, CJ Booth, LB Jilaveanu, W Damsky, M Sznol, HM Kluger, A Iwasaki, MW Bosenberg, Q Yan

Nature (Nature) USA, China, 20 October 2021

Oncology

Key words: Epigenetics, Melanoma [more]