Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 1 - 10 of 3451
01
SUN-148 Successful Development of Gonadotropin-releasing Hormone Neurons from Human Pluripotent Stem Cells

M Campbell, L Plummer, S Koli, R Balasubamanian, FRCP Edin, SB Seminara

Journal of the Endocrine Society (Endocrine Society) USA , 01 November 2025

Endocrinology

Organism: Human

Cell Line: hiPSC

02
Enhanced cargo of plasma alpha B crystallin in oligodendrocyte-derived exosomes accompanied by elevated expression of inflammatory factors in the temporal cortex of patients with refractory epilepsy

X Ji, D Wu, Y Xie, M Chen, Z Qi, N Zhou

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) China , 31 October 2025

Neuroscience

Key words: Crystallin, Oligodendrocyte exosome, Inflammatory factors, Intractable epilepsy

Organism: Human

Tissue: Brain

Pathological State: Epilepsy

03
Mitochondrial Network Fragmentation Leads to Dysfunction of Macrophages During Echinococcus multilocularis Protoscoleces Infection

Z Yang, Y Zhang, T Zhang, J Hou, M Tian, D Huang, Y Jiang, L Sun, P Wie, Y Ma

Pathogens (MDPI) China , 28 October 2025

Parasitology

Key words: Echinococcus multilocularis; protoscoleces; mitochondrial fragmentation; macrophage phagocytosis

Organism: Human, Mouse

Tissue: Liver

Pathological State: Parasitic Infection

04
Zinc as a Dual-Condition Inhibitor of HIF-1α/VEGF-α–Mediated Angiogenesis in Clear Cell Renal Carcinoma

GO Carlos, BM Neto, LFS Teixeira, Asena e Sousa, MB Mathor, MHB Marumo

Journal of Kidney Cancer and VHL (CODON Publications) Brazil , 28 October 2025

Oncology

Key words: Angiogenesis, Clear cell renal cell carcinoma, HIF-1α, Hypoxia, Zinc

Organism: Human

Pathological State: Cancer

Cell Line: 786-0

05
Investigating the Role of Salidroside in Alleviating Acute Pancreatitis by Inhibiting the RIPK1/RIPK3/MLKL Pathway-Mediated Necroptosis in Pancreatic Acinar Cells in Rats

Y Lin, X Ma, L Zhang, H Gu, X Fu, P Li

Journal of Inflammation Research (Taylor & Francis) China , 27 October 2025

Oncology

Key words: acute pancreatitis, salidroside, necroptosis, RIPK1/RIPK3/MLKL pathway, mitochondrial dysfunction

Organism: Rat

Tissue: Pancreas

Pathological State: Cancer

06
GPC-3 and AXL are essential factors and therapeutic targets for hepatocellular carcinoma

C Qiu, J Shi, S Yan, C Zhu, S Zhang, Y Feng, X Zhang, X Huang, J Xu

Clinical Cancer Bulletin (Springer) China , 27 October 2025

Oncology

Key words: Hepatocellular Carcinoma, Glypican-3, AXL, Therapeutic targets

Organism: Human

Tissue: Liver

Pathological State: Cancer

07
STING activates ZBP1-mediated PANoptosis to defend against HSV-1 retinal infection

W Liu, H Cui, L Wang, X Ge, X Zhu, X Liang, Z Chen, Y Gan, L Shi, X Hu, X Ding, Z Xu, X Liang, L Gong

Journal of Neuroinflammation (Springer) China , 27 October 2025

Ophthalmology

Key words: Herpes simplex virus, Acute retinal necrosis, Neuroinflammation, PANoptosis, STING, ZBP1

Organism: Mouse

Tissue: Eye

Pathological State: Viral Infection

08
Perinatal Fluoxetine Exposure Has No Major Effect on Myelin-Associated Glycoprotein and Myelin Basic Protein Levels in Auditory Brain Regions

JD Jagersma, M Visser, SJ Pyott, EMS Snoeren, JDA Oliver

Biology (MDPI) The Netherlands, Germany, Norway , 24 October 2025

Neuroscience

Key words: myelination; auditory cortex; fluoxetine; SSRI

Organism: Dog

Tissue: Brain

09
Exosome-mediated perturbation of the immune-bone metabolism axis: a mechanistic investigation into bone loss in a simulated microgravity environment

F Yang, C Chen, C Yang, R Chen, Z Liu, L Wen, H Xiao,B Geng, Y Xia

Artificial Cells Nanomedicine and Biotechnology (Taylor & Francis) China , 23 October 2025

Osteology

Key words: Simulated microgravity, exosomes, macrophages, bone immunity, bone loss

Organism: Mouse

Tissue: Bone

10
Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

X Zhou, J Cong, R Peng, D Yang, C Dong, J Xie, J Yan, J Kuang, F Li, LS Yeap, X Xie, H Yin, R Han, L Shen, Y Zhou, G Ning, S Wang, W Wang, L Ye

Advanced Science (Wiley Online Library) China , 23 October 2025

Immunology

Organism: Human

Tissue: Thyroid

Pathological State: Grave's Disease

Results 1 - 10 of 3451

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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