Customer Publications (A total of 1785 papers published)

Efficient cell death induction in human glioblastoma cells by photodynamic treatment with Tetrahydroporphyrin-Tetratosylat (THPTS) and ionizing irradiation

Peter Hambsch, Yury P. Istomin, Dimitri A. Tzerkovsky, Ina Patties, Jochen Neuhaus, Rolf-Dieter Kortmann, Stanislav Schastak, and Annegret Glasow

Oncotarget (Impact Journals) Germany, Belarus, 23 August 2017

Oncology

Key words: photodynamic therapy, glioblastoma, THPTS, combination, ionizing radiation [more]

Reactive oxygen species–mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression

Chia-Ling Hsieh, Che-Ming Liu, Hsin-An Chen, Shun-Tai Yang, Katsumi Shigemura, Koichi Kitagawa, Fukashi Yamamichi, Masato Fujisawa, Yun-Ru Liu, Wei-Hua Lee, Kuan-Chou Chen, Chia-Ning Shen, Cheng-Chieh Lin, Leland W. K. Chung and Shian-Ying Sung

Scientific Reports (Nature) Taiwan, 22 August 2017

Oncology

Key words: Stromelysin 1 (MMP-3) and 2 (MMP-10), prostate cancer-associated stromal fibroblasts (CAFs), extracellular matrix (ECM) [more]

Screening platform for cell contact guidance based on inorganic biomaterial micro/nanotopographical gradients

Qihui Zhou, Olga Castañeda Ocampo, Carlos Guimarães, Philipp Kuhn, Theo van Kooten, and Patrick van Rijn

Applied Materials and Interfaces (ACS Publications) The Netherlands, 21 August 2017

Stem Cell Research

Key words: Biomimetic surface, high-throughput screening, inorganic biomaterials, stem cell behavior, topographical gradient [more]

Bifidobacterium Infantis Ameliorates Chemotherapy-Induced Intestinal Mucositis Via Regulating T Cell Immunity in Colorectal Cancer Rats

Mi H, Dong Y, Zhang B, Wang H, Peter C.C.K, Gao P,Fu H, Gao Y

Celular Physiology And Biochemistry (Karger) China, 18 August 2017

Oncology

Key words: Bifidobacterium infantis, intestinal mucositis, 5-fluorouracil, oxaliplatin, CD4+CD25+Foxp3+ Tregs, CD4+CD17A+ cells, colorectal cancer [more]

An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis

Logan A. Walsh, Mariano J. Alvarez, Erich Y. Sabio, Marsha Reyngold, Vladimir Makarov, Suranjit Mukherjee, Ken-Wing Lee, Alexis Desrichard, Şevin Turcan, Martin G. Dalin, Vinagolu K. Rajasekhar, Shuibing Chen, Linda T. Vahdat, Andrea Califano, Timothy A. Chan

Cell Reports (Cell Press) USA, 15 August 2017

Oncology

Key words: ARACNe, MARINa, VIPER, breast, cancer, metastasis, transcription, TRIM25, EFP [more]

Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of Pseudomonas aeruginosa Infection

Bryan J. Berubea, Katherine R. Murphya, Matthew C. Torhanc, Nicholas O. Bowlinc, John D. Williamsc, Terry L. Bowlinc, Donald T. Moirc and Alan R. Hausera,b

Antimicrobial Agents and Chemotherapy (American Society for Microbiology) USA, 14 August 2017

Microbiology

Key words: Pseudomonas aeruginosa, abscesses, neutrophils, phenoxyacetamide inhibitors, type III secretion [more]

Effects of sulfur mustard on mesenchymal stem cells

Annette Schmidt, Dirk Steinritz, Simone Rothmiller, Horst Thiermann, A. Michael Scherer

Toxicology Letters (Elsevier) Germany, 14 August 2017

Toxicology

Key words: Sulfur mustard, mesenchymal stem cells, senescence, apoptosis, proliferation [more]

Attenuation of Follicular Helper T Cell–Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjögren's Syndrome

Gwenny M. Verstappen,Petra M. Meiners,Odilia B. J. Corneth,Annie Visser,Suzanne Arends,Wayel H. Abdulahad,Rudi W. Hendriks,Arjan Vissink,Frans G. M. Kroese,Hendrika Bootsma

Arthritis & Rheumatology (Wiley) The Netherlands, 13 August 2017

Rheumatology

Key words: CTLA-4Ig, CD4+ T cell , Sjögren's syndrome, marker ICOS [more]

Role of glial-cell-derived neurotrophic factor in salivary gland stem cell response to irradiation

Xiaohong Peng, Kärt Varendi, Martti Maimets, Jaan-Olle Andressoo, Rob P.Coppes

Radiotherapy and Oncology (Elsevier) The Netherlands, 04 August 2017

Oncology

Key words: Salivary glands, GDNF, stem cells, spheres, radiation-induced xerostomia [more]

Traditional Chinese medicine Danggui Buxue Tang inhibits colorectal cancer growth through induction of autophagic cell death

ST Chen, TY Lee, TH Tsai, YC Huang, YC Lin, CP Lin, HR Shieh, ML Hsu, CW Chi, MC Le, HH Chang, YJ Chen

Oncotarget (Impact Journals) Taiwan, 03 August 2017

Oncology

Key words: Danggui Buxue Tang, colorectal cancer, autophagy, traditional Chinese medicine, mammalian target of rapamycin (mTOR) [more]

The Prognostic Role of T1 Mapping Sequences: Can T1 Mapping Parameters Have a Role in Risk Stratification?

EY Choi, CH Park, TH Kim

Cardiovascular Imaging Asia (Kamje Press) South Korea, 31 July 2017

Cardiology

Key words: Cardiac magnetic resonance imaging, T1 mapping, Prognosis [more]

Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas

D Yan, J Kowal, L Akkari, A J Schuhmacher, J T Huse, B L West and J A Joyce

Oncogene (Nature) USA, Switzerland, 31 July 2017

Oncology

Key words: Glioblastomas, tumor microenvironment (TME)-mediated extrinsic resistance, PDGF-B-driven proneural glioma mouse model [more]

Parathyroid hormone regulates fates of murine osteoblast precursors in vivo

DH Balani, N Ono, HM Kronenberg

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 31 July 2017

Stem Cell Research

Key words: Parathyroid hormone, osteoblast precursors, bone biology, stem cells [more]

Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling

Jinlong Yin, Young Taek Oh, Jeong-Yub Kim, Sung Soo Kim, Eunji Choi, Tae Hoon Kim, Jun Hee Hong, Nakho Chang, Hee Jin Cho, Jason K. Sa, Jeong Cheol Kim, Hyung Joon Kwon, Saewhan Park, Weiwei Lin, Ichiro Nakano, Ho-Shin Gwak, Heon Yoo, Seung-Hoon Lee, Jeongwu Lee, Jong Heon Kim, Soo-Youl Kim, Do-Hyun Nam, Myung-Jin Park and Jong Bae Park

Cancer Research (AACR Publications) South Korea, 28 July 2017

Oncology

Key words: Necrosis, glioblastoma, transglutaminase 2 (TGM2), transcription factors (TF) [more]

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

Fenne L. Komdeur, Thalina M. Prins, Stephanie van de Wall, Annechien Plat, G. Bea A. Wisman, Harry Hollema, Toos Daemen , David N. Church, Marco de Bruyn, The Netherlands and Hans W. Nijman

OncoImmunology (Taylor and Francis) The Netherlands, 24 July 2017

Oncology

Key words: CD103, cervical cancer, intraepithelial T cells, therapeutic vaccination, tumor-infiltrating lymphocytes [more]

Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis

Johannes J. Kovarik, Elisabeth Kernbauer, Markus A. Hölzl, Johannes Hofer, Guido A. Gualdoni, Klaus G. Schmetterer, Fitore Miftari, Yury Sobanov, Anastasia Meshcheryakova, Diana Mechtcheriakova, Nadine Witzeneder, Georg Greiner, Anna Ohradanova-Repic, Petra Waidhofer-Söllner, Marcus D. Säemann, Thomas Decker, Gerhard J. Zlabinge

PLoS One (PLOS) Austria, 24 July 2017

Immunology

Key words: Cell metabolism, mammalian target of rapamycin (mTOR), interleukin (IL)-12 and anti-inflammatory IL-10 [more]

Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning

Julia Herbert, Horst Thiermann, Franz Worek,Timo Wille

Toxicology (Elsevier) Germany, 22 July 2017

Toxicology

Key words: Chemical warfare agents, nerve agents, pesticide, lung, PCLS, precision cut lung slices [more]

Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications

SethWinfree, Michael J.Ferkowicz, Pierre C.Dagher, Katherine J.Kelly, Michael T.Eadon, Timothy A.Sutton, Troy A.Markel, Mervin C.Yoder, Kenneth W.Dunn, Tarek M.El-Achkar

Translational Research (Elsevier) USA, 22 July 2017

Medical Imaging

Key words: 2D2 dimensional, 3D3 dimensional, LSM- light sheet microscopy, IHCS- imaging high content screening, VTEA -Volumetric tissue exploration and analysis, 3DTC-3 dimensional tissue cytometry

Neuron-Specific Fluorescence Reporter-Based Live Cell Tracing for Transdifferentiation of Mesenchymal Stem Cells into Neurons by Chemical Compound

Do Won Hwang, Hyun Woo Kwon, Jaeho Jang, Hee Jung Jung, Kwang Rok Kim, and Dong Soo Lee

Stem Cells International (Hindawi Publishing Corporation) South Korea, 20 July 2017

Stem Cell Research

Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration

Settimio Pacelli, Sayantani Basu, Jonathan Whitlow, Aparna Chakravarti, Francisca Acost, Arushi Varshney, Saman Modaresia, Cory Berkland, Arghya Paul

Advanced Drug Delivery Reviews (Elsevier) USA, 19 July 2017

Regenerative Medicine

Key words: Stem cell homing, growth factor delivery, chemoattractant gradients, endothelialization, extracellular matrix, bone graft substitutes, myocardial regeneration [more]

The c.1085A>G genetic variant of CSF1R gene regulates tumor immunity by altering the proliferation, polarization, and function of macrophages

Yu-Min Yeh, Shan-Ju Hsu, Peng-Chan Lin, Keng-Fu Hsu, Pei-Ying Wu, Wu-Chou Su, Jang-Yang Chang and Meng-Ru Shen

Clinical Cancer Research (AACR Publications) Taiwan, 19 July 2017

Oncology

Key words: Tumor, CSF1R, low VEGF expression, altering the polarization and function of macrophages [more]

Production of reactive persulfide species in chronic obstructive pulmonary disease

Tadahisa Numakura, Hisatoshi Sugiura, Takaaki Akaike, Tomoaki Ida, Shigemoto Fujii, Akira Koarai, Mitsuhiro Yamada, Katsuhiro Onodera, Yuichiro Hashimoto, Rie Tanaka, Kei Sato, Yutaka Shishikura, Taizou Hirano, Satoru Yanagisawa, Naoya Fujino, Tatsuma Okazaki, Tsutomu Tamada, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

Thorax (BMJ Journals) Japan, 19 July 2017

Pulmonology

Key words: Oxidative Stress [more]

MicroRNA 155-deficiency leads to decreased autoantibody levels and reduced severity of nephritis and pneumonitis in pristaneinduced lupus

Harald Leiss, Wilhelm Salzberger, Barbara Jacobs, Irina Gessl, Nicolas Kozakowski, Stephan Bluml, Antonia Puchner, Attila Kiss, Bruno K. Podesser, Josef S. Smolen,Georg H. Stummvoll

PLoS One (PLOS) Austria, 18 July 2017

Immunology

Key words: Systemic lupus, miR155-deficient, PBS-injected mice, glomerulonephritis, pneumonitis [more]

Analysis of cysteine-X-cysteine motif chemokine ligands 9, 10, and 11, their receptor CXCR3, and their possible role on the recruitment of immune cells at the maternal–conceptus interface in pigs†

Jisoo Han, Min Jeong Gu, Inkyu Yoo, Yohan Cho,i Hwanhee Jang, Minjeong Kim, Cheol-Heui Yun, Hakhyun Ka

Biology of Reproduction (Oxford University Press) South Korea, 15 July 2017

Immunology

Key words: Pig, pregnancy, uterus, endometrium, CXCL9, CXCL10, CXCL11 [more]

Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1

Leo Edlinger, Angelika Berger-Becvar, Ingeborg Menzl, Gregor Hoermann, Georg Greiner, Eva Grundschober, Zsuzsanna Bago-Horvath, Wael Al-Zoughbi, Gerald Hoefler, Christine Brostjan, Lars Gille, Richard Moriggl, Andreas Spittler, Veronika Sexl, Andrea Hoelbl-Kovacic

British Journal of Haematology (Wiley) Austria, 14 July 2017

Oncology

Key words: The p21-activated kinases (PAKs), BCR/ABL1+ haematopoietic malignancy, leukaemic cells [more]

Placental homing peptide-microRNA inhibitor conjugates for targeted enhancement of intrinsic placental growth signaling

F Beards, LE Jones, J Charnock, K Forbes, LK Harris

Theranostics (NCBI) UK, 14 July 2017

Reproductive Medicine

Key words: fetal growth restriction, IGF-II, microRNA, placenta, proliferation, pregnancy [more]

RIP3 attenuates the pancreatic damage induced by deletion of ATG7

Xiaodong Zhou, Li Xie, Leizhou Xia, Frank Bergmann, Markus W Büchler, Guido Kroemer, Thilo Hackert and Franco Fortunato

Cell Death & Disease (Nature) Germany, 13 July 2017

Gastroenterology

Key words: Pancreatitis, Rip3, acinar cells, autophagy and necroptosis [more]

Small cell lung cancer: model of circulating tumor cell tumorospheres in chemoresistance

Lukas Klameth, Barbara Rath, Maximilian Hochmaier, Doris Moser, Marlene Redl, Felicitas Mungenast, Katharina Gelles, Ernst Ulsperger, Robert Zeillinger and Gerhard Hamilton

Scientific Reports (Nature) Austria, 13 July 2017

Oncology

Key words: Small cell lung cancer (SCLC), circulating tumor cells (CTCs), Ki67 and carbonic anhydrase 9 (CAIX) [more]

Tailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson's disease

Ming-Li Choua, Joe-Wei Wu, Flore Gouel, Aurélie Jonneaux, Kelly Timmerman, Ting-Yi Renn, Charlotte Laloux, Hung-Ming Chang, Liang-Tzung Lin, Jean-Christophe Devedjian, David Devos , Thierry Burnou

Biomaterials (Elsevier) Taiwan, 12 July 2017

Biological Materials

Key words: Platelet lysate, neuroprotection, parkinson, MPTP, neurotrophins, growth factors [more]

CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions

Hong-Yue Lai, Ling-Wei Hsu, Hsin-Hwa Tsai, Yu-Chih Lo, Shang-Hsun, Yang Ping-Yen Liu, Ju-Ming Wang

Cardiovascular Research (Oxford University Press) Taiwan, 11 July 2017

Cardiology

Key words: CEBPD, inflammation, macrophages, PTX3, statins [more]

Instructing cells with programmable peptide DNA hybrids

Ronit Freeman, Nicholas Stephanopoulos, Zaida Álvarez, Jacob A Lewis, Shantanu Sur, Chris M Serrano, Job Boekhoven, Sungsoo S. Lee and Samuel I. Stupp

Nature Communications (Nature) USA, 10 July 2017

Cell Biology

Key words: Native extracellular matrix, peptide-DNA (P-DNA) [more]

Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis

Mirella Tanori, Arianna Casciati, Francesco Berardinelli, Simona Leonardi, Emanuela Pasquali, Francesca Antonelli, Barbara Tanno, Paola Giardullo, Alessandro Pannicelli, Gabriele Babini, Ilaria De Stefano, Antonella Sgura, Mariateresa Mancuso, Anna Saran, and Simonetta Pazzaglia

Oncotarget (Impact Journals) Italy, 07 July 2017

Oncology

Key words: cerebellum, expression profiles, medulloblastoma, apoptosis, senescence [more]

A novel in vitro model of villitis of unknown etiology demonstrates altered placental hormone and cytokine profile

Hayley Derricott, Alexander E.P. Heazell, Susan L. Greenwood, Rebecca L. Jones

American Journal of Reproductive Immunology (Wiley) UK, 06 July 2017

Reproductive Medicine

Key words: Placental dysfunction, villitis of unknown etiology, T cell, fetal growth restriction [more]

Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion

Tereza Vanova, Zaneta Konecna, Zuzana Zbonakova, Giuseppe La Venuta, Karolina Zoufalova, Sarka Jelinkova,Miroslav Varecha, Vladimir Rotrekl, Pavel Krejci, Walter Nickel, Petr Dvorak, Michaela Kunova Bosakova

Stem Cells (Wiley) Czech Republic, 06 July 2017

Stem Cell Research

Key words: Human pluripotent stem cells (hPSCs), fibroblast growth factor (FGF) receptors, hepatocellular carcinoma (TEC) [more]

Increased migration of antigen presenting cells to newly-formed lymphatic vessels in transplanted kidneys by glycol-split heparin

Ditmer T. Talsma, Kirankumar Katta, Miriam Boersema, Saritha Adepu,Annamaria Naggi, Giangiacomo Torri, Coen Stegeman, Gerjan Navis, Harry van Goor,Jan-Luuk Hillebrands,Saleh Yazdani, Jacob van den Born

PLoS One (PLOS) The Netherlands, 30 June 2017

Transplantation Medicine

Key words: Chronic renal transplant, lymphatic chemokine-proteoglycan, renal graft [more]

Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation

Tao Peng, R. Savanh Chanthaphavong, Sijie Sun, James A. Trigilio, Khamsone Phasouk, Lei Jin, Erik D. Layton, Alvason Z. Li, Colin E. Correnti, Willem De van der Schueren, Julio Vazquez, Diana R. O’Day, Ian A. Glass, David M. Knipe, Anna Wald, Lawrence Corey, Jia Zhu

Journal Of Experimental Medicine (Rockefeller University Press) USA, 29 June 2017

Neuroscience

Key words: Herpes simplex virus (HSV), keratinocytes, IL-17c , nervous system [more]

Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells

Dong Hoon Kang, Doo Jae Lee, Sunmi Lee, So-Young Lee, Yukyung Jun, Yerin Kim, Youngeun Kim, Ju-Seog Lee, Dae-Kee Lee, Sanghyuk Lee, Eek-Hoon Jho, Dae-Yeul Yu and Sang Won Kang

Nature Communications (Nature) South Korea, 28 June 2017

Oncology

Key words: Colon cancer, mechanisms of disease [more]

Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells

Shih-Ming Chen, Bing-Yen Wang, Che-Hsin Lee, Hsueh-Te Lee, Jung-Jung Li, Guan-Ci Hong, Yu-Chieh Hung, Peng-Ju Chien, Che-Ying Chang, Li-Sung Hsu, and Wen-Wei Chang

Oncotarget (Impact Journals) Taiwan, 27 June 2017

Oncology

Key words: hinokitiol, miR-494-3p, BMI1, breast cancer, cancer stem cells [more]

The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis

Xiaodong Zhou, Li Xie, Frank Bergmann, Volker Endris, Oliver Strobel, Markus W Büchler, Guido Kroemer, Thilo Hackert and Franco Fortunato

Cell Death Discovery (Nature) Germany, 19 June 2017

Gastroenterology

Key words: Apoptosis, chronic pancreatitis, macroautophagy, necroptosis [more]

Breviscapine (BVP) inhibits prostate cancer progression through damaging DNA by minichromosome maintenance protein-7 (MCM-7) modulation

Yang-boGuan, Dong-rongYang, Shao-junNong, JianNi, Chun-huiHu, JianLi, JinZhu, Yu-xiShan

Biomedicine and Pharmacotherapy (Elsevier) China, 17 June 2017

Oncology

Key words: Breviscapine, human prostate cancer, DNA damage, MCM-7, Apoptosis [more]

Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation

Pounami Samadder, Tereza Suchánková, Ondřej Hylse, Prashant Khirsariya, Fedor Nikulenkov, Stanislav Drápela, Nicol Straková, Petr Vaňhara, Kateřina Vašíčková, Hana Kolářová, Lucia Binó, Miroslava Bittová, Petra Ovesná, Peter Kollár, Radek Fedr, Milan Ešner, Josef Jaroš, Aleš Hampl, Lumír Krejčí, Kamil Paruch and Karel Souček

Molecular Cancer Therapeutics (AACR Publications) Czech Republic, 15 June 2017

Oncology

Key words: Tumor cells, serine threonine kinase, DNA antimetabolites [more]

Inhibition of the NOD-like receptor protein 3 inflammasome is protective in juvenile influenza A virus infection

Bria M. Coates, imageKelly L. Staricha, imageNandini Ravindran, imageClarissa M. Koch, imageYuan Cheng, imageJennifer M. Davis, imageDale K. Shumaker and imageKaren M. Ridge

Frontiers in Immunology (Frontiers Media S.A.) USA, 10 June 2017

Immunology

Key words: Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection [more]

Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer

Felicitas Mungenast, Stefanie Aust, Ignace Vergote, Adriaan Vanderstichele, Jalid Sehouli, Elena Braicu, Sven Mahner, Dan Cacsire Castillo-Tong, Robert Zeillinger, and Theresia Thalhammer1

Oncology Letters (Spandidos Publications) Austria, Belgium, Germany, 03 June 2017

Oncology

Key words: pithelial ovarian cancer, estrogen, estrogen metabolizing enzymes, STS, sulfotransferase, SULT1E1, E2, ovarian cancer [more]

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

Valerie N Babinsky, Fadil M Hannan, Reshma D Ramracheya, Quan Zhang, M Andrew Nesbit, Alison Hugill, Liz Bentley , Tertius A Hough , Elizabeth Joynson Michelle Stewart, Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Caroline M Gorvin, Enikö Kallay, Sara Wells, Roger D Cox , Duncan Richards, Patrik Rorsman, Rajesh V Thakker

Endocrinology (Oxford University Press) UK, 02 June 2017

Endocrinology

Key words: Calcium-Sensing Receptor, CaSR, Hyperglycemia, Calcilytic Therapy, glucose homeostasis, Diabetes [more]

Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice

Tse-Hung Huang, Chin-Chang Chen, Hsuan-Miao Liu, Tzung-Yan Lee and Sue-Heui Shieh

Scientific Reports (Nature) Taiwan, 02 June 2017

Immunology, Virology

Key words: Age-related autoimmune hepatitis, cell senescence, apoptosis, concanavalin A (Con A), [more]

Extracellular matrix hydrogel derived from human umbilical cord as a scaffold for neural tissue repair and its comparison with extracellular matrix from porcine tissues

Zuzana Kočí, Karel Výborný, Jana Dubišová, Irena Vacková, Aleš Jäger, Oleg Lunov, Klára Jiráková, and Šárka Kubinová

Tissue Engineering Part C (Mary Ann Liebert Inc.) Czech Republic, 01 June 2017

Regenerative Medicine

Key words: Hydrogel, Umbilical Cord, Neural Tissue Repair, Extracellular Matrix, Porcine Tissues [more]

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Andrea E. Calvert, Alexandra Chalastanis, Yongfei Wu, Lisa A. Hurley, Fotini M. Kouri, Yingtao Bi, Maureen Kachman, Jasmine L. May, Elizabeth Bartom, Youjia Hua, Rama K. Mishra, Gary E. Schiltz, Oleksii Dubrovskyi, Andrew P. Mazar, Marcus E. Peter, Hongwu Zheng, C. David James, Charles F. Burant, Navdeep S. Chandel, Ramana V. Davuluri, Craig Horbinski, Alexander H. Stegh

Cell Reports (Cell Press) USA, 30 May 2017

Oncology

Key words: wild-type IDH1, GBM, metabolism, differentiation, NADPH, lipids, reactive oxygen species (ROS), EGFR, targeted therapy [more]

Automated Image Analysis of HER2 Fluorescence In Situ Hybridization to Refine Definitions of Genetic Heterogeneity in Breast Cancer Tissue

Gedmante Radziuviene, Allan Rasmusson, Renaldas Augulis, Daiva Lesciute-Krilaviciene, Aida Laurinaviciene, Eduard Clim, and Arvydas Laurinavicius

BioMed Research International (Hindawi Publishing Corporation) Lithuania, Austria, 28 May 2017

Medical Image Analysis

Key words: Automated Image Analysis, HER2 FISH, Genetic Heterogeneity, Breast Cancer [more]

Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling

Yu-Ching Huang, Ming-ShiunTsai, Pei-Chi Hsieh, Jheng-Hong Shih, Tsu-Shing Wang, Yi-Chun Wang, Ting-Hui Lin, Sue-Hong Wang

Toxicology and Applied Pharmacology (Elsevier) China, 27 May 2017

Oncology

Key words: Cisplatin nephrotoxicity, ERK, Galangin, Inflammation, NF-κB, Oxidative stress [more]

Hepatic IFIT3 predicts interferon-α therapeutic response in patients of hepatocellular carcinoma

Yingyun Yang,Ye Zhou,Jin Hou,Chunmei Bai,Zhenyang Li,Jia Fan,Irene O.L. Ng,Weiping Zhou,Huichuan Sun,Qiongzhu Dong,Joyce M.F. Lee,Chung-Mau Lo,Kwan Man,Yun Yang,Nan Li,Guoshan Ding,Yizhi Yu,Xuetao Cao

Hepatology (Wiley) China, 26 May 2017

Oncology

Key words: Adjuvant interferon-α (IFN-α), hepatocellular carcinoma (HCC), IFIT3, [more]

QUICK FIRE CASES- SESSION III

European Heart Journal (Oxford University Press) Denmark, 25 May 2017

Cardiology

Key words: Myocardium, diagnosis, fire - disaster, s fire - physical, phenomenon cardiac, mri [more]

SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor

Xianghui Zou, Yueming Zhu, Seong-Hoon Park, Guoxiang Liu, Joseph O'Brien, Haiyan Jiang and David Gius

Cancer Research (AACR Publications) USA, 23 May 2017

Oncology

Key words: Isocitrate dehydrogenase IDH2, α-ketoglutarate, cancer cells, SIRT3 [more]

Single allele Lmbrd1 knockout results in cardiac hypertrophy

Tseng LT, Lin CL, Pan KH, Tzen KY, Su MJ, Tsai CT, Li YH, Li PC, Chiang FT, Chang SC, Chang MF

Journal of the Formosan Medical Association (Elsevier) Taiwan, 23 May 2017

Cardiology

Key words: Cardiac hypertrophy, Disease animal model, Gene knockout, Mouse Lmbrd1 gene, Human LMBRD1 gene, LMBD1 protein [more]

MicroRNA-146a governs fibroblast activation and joint pathology in arthritis

Victoria Saferdinga, Antonia Puchnera, Eliana Goncalves-Alvesa, Melanie Hofmanna, Michael Bonellia, Julia S. Brunnerb, Emine Sahinb, Birgit Niederreitera, Silvia Hayera, Hans P. Kienera, Elisa Einwallnerc, Ramzi Nehmard, Raphael Carapitod, Philippe Georgeld, Marije I. Koenderse, Mark Boldinf, Gernot Schabbauerb, Mariola Kurowska-Stolarskag, Günter Steinera, h, Josef S. Smolena, Kurt Redlicha, Stephan Blüml

Journal of Autoimmunity (Elsevier) Austria, 22 May 2017

Rheumatology

Key words: Synovial fibroblasts, miR-146a, tumor necrosis factor (TNF) receptor, factor 6 (TRAF6), osteoprotegerin (OPG) [more]

Significance of B10 cell in patients with thymoma complicated with myasthenia gravis

Y Lu, F Meng, Y Yang, L Li, D Wang, Y Cui, S Dong, W Wang

Oncotarget (Impact Journals) China, 17 May 2017

Oncology

Key words: regulatory B cell, B10 cell, thymoma, myasthenia gravis, autoimmune abnormality [more]

Enhanced Bruton's Tyrosine Kinase Activity in Peripheral Blood B Lymphocytes From Patients With Autoimmune Disease

Odilia B. J. Corneth,Gwenny M. P. Verstappen,Sandra M. J. Paulissen,Marjolein J. W. de Bruijn,Jasper Rip,Melanie Lukkes,Jan Piet van Hamburg,Erik Lubberts,Hendrika Bootsma,Frans G. M. Kroese,Rudi W. Hendriks

Arthritis & Rheumatology (Wiley) The Netherlands, 10 May 2017

Rheumatology

Key words: Bruton's tyrosine kinase (BTK), B cell receptor (BCR), Sjögren's syndrome (SS), BTK phosphorylation [more]

Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time

Tzyy Yue Wong,Chiung-Hsin Chang,Chen-Hsiang Yu,Lynn L. H. Huang

Aging Cell (Wiley) Taiwan, 04 May 2017

Stem Cell Research

Key words: Hyaluronan (HA), mesenchymal stem cells (MSCs), cellular aging, human placenta-derived MSCs (PDMSC) [more]

CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice

Sreya Bagchi, Ying He, Hong Zhang, Liang Cao, Ildiko Van Rhijn, D. Branch Moody, Johann E. Gudjonsson, and Chyung-Ru Wang

Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 02 May 2017

Immunology

Key words: Autoimmunity, Immunology [more]

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Yuan-Hua Wu, Chi-Wei Hong, Yi-Ching Wang, Wei-Jan Huang, Ya-Ling Yeh, Bour-Jr Wang1, Ying-Jan Wang, Hui-Wen Chiu

Cancer Letters (Elsevier) Taiwan, 24 April 2017

Oncology

Key words: DNA damage, DNA repair, Ubiquitin–proteasome system, Triple-negative breast cancer [more]

Cytotoxicity of Natural Killer Cells Activated Through NKG2D Contributes to the Development of Bronchiolitis Obliterans in a Murine Heterotopic Tracheal Transplant Model

T. Kawakami,K. Ito,Y. Matsuda,M. Noda,A. Sakurada,Y. Hoshikawa,Y. Okada,K. Ogasawara

American Journal of Transplantation (Wiley) Japan, 21 April 2017

Transplantation Medicine

Key words: Basic (laboratory) research/science, lung transplantation/pulmonology, bronchiolitis obliterans (BOS), natural killer (NK) cells/NK receptors [more]

Two different, mutually exclusively distributed, TP53 mutations in ovarian and peritoneal tumor tissues of a serous ovarian cancer patient: indicative for tumor origin?

Nyamdelger Sukhbaatar, Anna Bachmayr-Heyda, Katharina Auer, Stefanie Aust, Simon Deycmar, Reinhard Horvat and Dietmar Pils

Molecular Case Studies (CSH Press) Austria, 14 April 2017

Oncology

Key words: Mutually exclusive p53 mutations in ovarian cancer [more]

Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells

Wooram Park , Andrew C. Gordon, Soojeong Cho, Xiaoke Huang, Kathleen R. Harris, Andrew C. Larson, and Dong-Hyun Kim

Applied Materials and Interfaces (ACS Publications) USA, 13 April 2017

Oncology

Key words: And image-guided therapy, cancer immunotherapy interferon-gamma (IFN-γ), microspheres, natural killer (NK) cells infiltration [more]

Extravillous Trophoblast and Endothelial Cell Crosstalk Mediates Leukocyte Infiltration to the Early Remodeling Decidual Spiral Arteriole Wall

Ruhul H. Choudhury, Caroline E. Dunk, Stephen J. Lye, John D. Aplin, Lynda K. Harris and Rebecca L. Jones

The Journal of Immunology (American Association of Immunologists) UK, Canada, 10 April 2017

Immunology

Key words: Decidual spiral arteriole (SpA), uterine decidual NK (dNK) cells, extravillous trophoblasts (EVTs), chemokines [more]

EGFR in Tumor-associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Sriram Srivatsa, Mariel C. Paul, Claudia Cardone, Martin Holcmann, Nicole Amberg, Paulina Pathria, Michaela A. Diamanti, Markus Linder, Gerald Timelthaler, Hans P. Dienes, Lukas Kenner, Fritz Wrba, Gerald W. Prager, Stefan Rose-John, Robert Eferl, Giuseppina Liguori, Gerardo Botti, Erika Martinelli, Florian R. Greten, Fortunato Ciardiello, Maria Sibilia

Gastroenterology (Elsevier) Austria, 09 April 2017

Oncology

Key words: Tumor microenvironment, cytokine, CRC, colon cancer [more]

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Kohei Shitara, Toshihiko Doi, Osamu Nagano, Chiyo K. ImamuraTakeshi OzekiYuya IshiiKenji TsuchihashiShunji TakahashiTakako E. NakajimaShuichi HironakaMiki FukutaniHiromi HasegawaShogo NomuraAkihiro SatoYasuaki EinagaTakeshi KuwataHideyuki SayaEmail authorAtsushi Ohtsu

Gastric Cancer (Springer) Japan, 07 April 2017

Oncology

Key words: Cancer stem cell, CD44 variant positive, Gastric cancer, Sulfasalazine xCT [more]

Surviving murine experimental sepsis affects the function and morphology of the inner ear

Natalie Fischer, Nina Maria Mathonia, Georges Hollerich, Julian Veser, Leyla Pinggera, Daniel Dejaco, Rudolf Glueckert, Anneliese Schrott-Fischer, Peter Lackner, Herbert Riechelmann, Joachim Schmutzhard

Biology Open (The Company of Biologists) Austria, 04 April 2017

Physiology

Key words: Sepsis, Hearing loss, Inner ear, Inflammation, Apoptosis [more]

Intracerebral delivery of the M2 polarizing cytokine interleukin 13 using mesenchymal stem cell implants in a model of temporal lobe epilepsy in mice

Idrish Ali, Stephanie Aertgeerts, Debbie Le Blon, Daniele Bertoglio, Chloe Hoornaert, Peter Ponsaerts, Stefanie Dedeurwaerdere

Official Journal of the International League Against Epilsepy (Wiley) Belgium, 04 April 2017

Transplantation Medicine

Key words: IL-13 MSCs, acid–induced status epilepticus, video–electroencephalography, F4/80+ cells [more]

Information Limits of Optical Microscopy: Application to Fluorescent Labelled Tissue Section

Renata Rychtáriková, Georg Steiner, Michael B. Fischer,Dalibor Šty

Bioinformatics and Biomedical Engineering (Springer) Austria, Czech Republic, 01 April 2017

Microscopy

Key words: Electromagnetic centroid, Point divergence gain, Superresolution, 3D structure reconstruction [more]

High expression of CASZ1 is associated with poor prognosis in ovarian cancer

YJ Chuang, YL Liang, YL Chen, TM Hong, KF Hsu

Cancer Research (AACR Publications) Taiwan, 01 April 2017

Oncology

Key words: High expression of CASZ1 is associated with poor prognosis in ovarian cancer [more]

Brilliant Blue G, but not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease

Enéas G. Ferrazoli, Héllio D.N. De Souza, Isis C. Nascimento, Ágatha Oliveira-Giacomelli, Telma T. Schwindt, Luiz R. Britto, Henning Ulrich

Cell Transplantation (SAGE Journals) Brazil, 01 April 2017

Neuroscience

Key words: Parkinson's disease (PD), P2X7 receptor, brilliant Blue G (BBG), PGC-1α, fenofibrate [more]

ICAM-1 binding rhinoviruses enter HeLa cells via multiple pathways and travel to distinct intracellular compartments for uncoating

H Ganjian, C Zietz, D Mechtcheriakova, D Blaas, R Fuchs

Viruses (MDPI) Austria, 01 April 2017

Virology

Key words: human rhinoviruses, ICAM-1, productive uncoating, endocytosis, clathrin, dynamin, macropinocytosis, actin, dynein [more]

Colibactin contributes to the hypervirulence of pks+ K1 CC23 Klebsiella pneumoniae in mouse meningitis infections

Min-Chi Lu, Ying-Tsong Chen, Ming-Ko Chiang, Yao-Chen Wang, Pei-Yi Hsiao, Yi-Jhen Huang, Ching-Ting Lin, Ching-Chang Cheng, Chih-Lung Liang and Yi-Chyi Lai

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) Taiwan, 31 March 2017

Microbiology

Key words: Colibactin, pks+ K1 CC23 Klebsiella pneumoniae, Mouse Meningitis [more]

Early, but not late treatment with human umbilical cord blood-derived mesenchymal stem cells attenuates cisplatin nephrotoxicity through immunomodulation

Ji Hyeon Park, Hye Ryoun Jang, Do Hee Kim, Ghee Young Kwon, Jung Eun Lee, Wooseong Huh, Soo Jin Choi, Wonil Oh, Ha Young Oh, Yoon-Goo Kim

American Journal of Physiology (APS Journals) South Korea, 29 March 2017

Physiology

Key words: Acute kidney injury, Cisplatin nephrotoxicity, immunomodulation, mesenchymal stem cells, regulatory T cells [more]

HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

Niek G. J. Leus, Thea van den Bosch, Petra E. van der Wouden, Kim Krist, Maria E. Ourailidou, Nikolaos Eleftheriadis, Loes E. M. Kistemaker, Sophie Bos, Rutger A. F. Gjaltema, Solomon A. Mekonnen, Rainer Bischoff, Reinoud Gosens, Hidde J. Haisma and Frank J. Dekker

Scientific Reports (Nature) The Netherlands, 27 March 2017

Immunology

Key words: Mechanism of action, Pharmacodynamics [more]

Non-thermal air plasma promotes the healing of acute skin wounds in rats

S. Kubinova, K. Zaviskova, L. Uherkova, V. Zablotskii, O. Churpita, O. Lunov and A. Dejneka

Scientific Reports (Nature) Czech Republic, 24 March 2017

Regenerative Medicine

Key words: Non-thermal plasma (NTP), skin wound, atmospheric pressure air plasma, histological and gene expression analysis [more]

Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure

Franziska Roth-Walter, Cornelia Bergmayr, Sarah Meitz, Stefan Buchleitner, Caroline Stremnitzer, Judit Fazekas, Anna Moskovskich, Mario A. Müller, Georg A. Roth, Krisztina Manzano-Szalai, Zdenek Dvorak, Alina Neunkirchner and Erika Jensen-Jarolim

Scientific Reports (Nature) Austria, 23 March 2017

Immunology

Key words: Acrolein, BALB/c allergy model, T cells , D2F2 tumor cells [more]

Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

Gary Kohanbash, Diego A. Carrera, Shruti Shrivastav, Brian J. Ahn, Naznin Jahan, Tali Mazor, Zinal S. Chheda, Kira M. Downey, Payal B. Watchmaker, Casey Beppler, Rolf Warta, Nduka A. Amankulor, Christel Herold-Mende, Joseph F. Costello, and Hideho Okada

JCI The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, Germany, 20 March 2017

Oncology, Immunology

Key words: Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas [more]

Histone Methyltransferase G9a Drives Chemotherapy Resistance by Regulating the Glutamate–Cysteine Ligase Catalytic Subunit in Head and Neck Squamous Cell Carcinoma

Chia-Wen Liu, Kuo-Tai Hua, Kai-Chun Li, Hsiang-Fong Kao, Ruey-Long Hong, Jenq-Yuh Ko, Michael Hsiao, Min-Liang Kuo and Ching-Ting Tan

Molecular Cancer Therapeutics (AACR Publications) Taiwan, 06 March 2017

Oncology

Key words: Neck squamous cell carcinomas (HNSCC), histone methyltransferase, apoptosis, glutamate-cysteine ligase catalytic subunit (GCLC) [more]

Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway

Jung Hoo Hwang, Soo Jung Park, Won Gyu Ko, Seong-Mun Kang, Da Bin Lee, Junho Bang, Byung-Joo Park, Chung-Beum Wee, Dae Joon Kim, Ik-Soon Jang, and Jae-Hong Ko

American Journal of Cancer Research (NCBI) South Korea, USA, 01 March 2017

Oncology

Key words: Cordycepin, nitric oxide, ERK, slug, lung cancer, apoptosis [more]

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Yan-Jiun Huang, Ching-Kuo Yang, Po-Li Wei, Thanh-Tuan Huynh, Jacqueline Whang-Peng, Tzu-Ching Meng, Michael Hsiao, Yew-Ming Tzeng, Alexander TH Wu and Yun Yen

Journal of Hematology and Oncology (Springer) Taiwan, Vietnam, 28 February 2017

Oncology

Key words: M2 tumor-associated macrophages, Colon tumorigenesis, Stemness, YAP1, Ovatodiolide [more]

Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation

Ya-Ting Chu, Shu-Wen Wan, Yu-Chang Chang, Chien-Kuo Lee, Betty A Wu-Hsieh, Robert Anderson and Yee-Shin Lin

Laboratory Investigation (Nature) Taiwan, 27 February 2017

Immunology, Virology

Key words: Dengue virus, mast cells, DHF/DSS, chemokines [more]

Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1

Anchana Rathinasamy, Christoph Domschke, Yingzi GeHans-Henning Böhm, Steffen Dettling, David Jansen, Felix Lasitschka, Ludmila Umansky, Markus H. Gräler, Jennifer Hartmann, Christel Herold-Mende, Florian Schuetz, Philipp Beckhove

Cancer Immunology, Immunotherpay (Springer) Germany, 21 February 2017

Oncology

Key words: Antigen-specific regulatory T cells, Bone marrow, Sphingosine-1-phosphate receptor 1, Exit, Breast cancer patients [more]

Ccdc181 is a microtubule binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia

Thomas Schwarza, Barbara Prielera, Johannes A. Schmidb, Pawel Grzmilc, Juergen Neesena

European Journal of Cell Biology (Elsevier) Austria, 20 February 2017

Cell Biology

Key words: Ccdc181, Cilia, Manchette, Microtubules, Motility, Hook1, Spermatogenesis [more]

Diagnostic and prognostic relevance of CP2c and YY1 expression in hepatocellular carcinoma

Ji Sook Kim, Seung Han Son, Min Young Kim, DongHo Choi, Ik-Soon Jang, Seung Sam Paik, Ji Hyung Chae, Vladimir N. Uversky, and Chul Geun Kim

Oncotarget (Impact Journals) South Korea, USA, 17 February 2017

Oncology

Key words: hepatocellular carcinoma (HCC), CP2c, YY1, diagnosis, prognosis [more]

Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1

Ee Soo Lee, Llorenç Solé Boldo, Bernadette O. Fernandez, Martin Feelisch and Martin C. Harmsen

Scientific Reports (Nature) The Netherlands, 17 February 2017

Immunology

Key words: Endothelial dysfunction, TAK1 (MAP3K7), ERK5 (MAPK7), TGF-β [more]

Subcellular probes for neurochemical recording from multiple brain sites

Helen N. Schwerdt, Min Jung Kim, Satoko Amemori, Daigo Homma, Tomoko Yoshida, Hideki Shimazu, Harshita Yerramreddy, Ekin Karasan, Robert Langer, Ann M. Graybiel and Michael J. Cima

Lab on a Chip (Royal Society of Chemistry) USA, 15 February 2017

Nanomedicine

Key words: striatum, voltammetry, implantable sensors, microelectrodes, dopamine [more]

Editor's highlight: periodic exposure to smartphone-mimic low-luminance blue light induces retina damage through Bcl-2/BAX-dependent apoptosis

Cheng-Hui Lin, Man-Ru Wu, Ching-Hao Li, Hui-Wen Cheng, Shih-Hsuan Huang, Chi-Hao Tsai, Fan-Li Lin, Jau-Der Ho, Jaw-Jou Kang, George Hsiao, Yu-Wen Cheng

Toxicological Sciences (Oxford University Press) Taiwan, 10 February 2017

Toxicology

Key words: blue light, age-related macular degeneration, apoptosis, Bax, Bcl-2, FasL, caspase-3. [more]

The lymphatic phenotype of lung allografts in patients with bronchiolitis obliterans syndrome and restrictive allograft syndrome

Traxler D, Schweiger T, Schwarz S, Schuster MM, Jaksch P, Lang G, Birner P, Klepetko W, Ankersmit HJ, Hoetzenecker K.

Transplantation (Wolters Kluwer) Austria, 10 February 2017

Transplantation Medicine

Key words: Lymphatic Phenotype, Lung Allograft, Bronchiolitis Obliterans Syndrome, Restrictive Allograft Syndrome [more]

Elatoside C protects against ox-LDL-induced HUVECs injury by FoxO1-mediated autophagy induction

Yun Luo, Xiangbao Meng, Ping Zhou, Shan Lu, Meng Qin, Xudong Xu, Guibo Sun , Xiaobo Sun,

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) China, 09 February 2017

Neuroscience

Key words: Autophagy, apoptosis, Elatoside C, ox-LDL, FoxO1, HUVECs [more]

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Wei-Chun HuangFu, Min-Wu Chao, Chun-Chun Cheng, Yu-Chieh Wei, Yi-Wen Wu, Jing-Ping Liou, George Hsiao, Yu-Ching Lee and Chia-Ron Yang

Scientific Reports (Nature) Taiwan, 09 February 2017

Oncology

Key words: Histone deacetylase (HDAC), cell lines HL-60 and MOLT-4, apoptosis [more]

Diffusion radiomics analysis of intratumoral heterogeneity in a murine prostate cancer model following radiotherapy: Pixelwise correlation with histology

Yu-Chun Lin, Gigin Lin, Ji-Hong Hong, Yi-Ping Lin, Fang-Hsin Chen, Shu-Hang Ng, Chun-Chieh Wang

Journal Of Magnetic Resonance Imaging (Wiley) Taiwan, 08 February 2017

Oncology

Key words: Apparent diffusion coefficient (ADC), TRAMP-C1, tumor, [more]

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

Laura Pasetto, Silvia Pozzi, Mariachiara Castelnovo, Manuela Basso, Alvaro G. Estevez, Stefano Fumagalli, Maria Grazia De Simoni, Valeria Castellaneta, Paolo Bigini, Elena Restelli, Roberto Chiesa, Francesca Trojsi, Maria Rosaria Monsurrò, Leonardo Callea, Miroslav Malešević, Gunter Fischer, Mattia Freschi, Massimo Tortarolo, Caterina Bendotti and Valentina Bonetto

Journal of Neuroscience (Society for Neuroscience) Italy, 08 February 2017

Neuroscience

Key words: Amyotrophic lateral sclerosiscy, clophilin A, neuroinflammation [more]

Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury

HH Chen, H Yuan, H Cho, Y Feng, S Ngoy, ATN Kumar, R Liao, L Josephson, DE Sosnovik

Theranostics (NCBI) USA, 08 February 2017

Cardiology

Key words: NA, RNA, Inflammation, Ischemia, Nanoprobe, Imaging. [more]

Laser deposition of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) − Lysozyme microspheres based coatings with anti-microbial properties

V. Grumezescu, A.M. Holban, L.E. Sima, M.B. Chiritoiu, G.N. Chiritoiu, A.M. Grumezescu, L. Ivan, F. Safciuc, F. Antohe, C. Florica, C.R. Luculescu, M.C. Chifiriuc, G. Socol

International Journal of Pharmaceutics (Elsevier) Romania, 07 February 2017

Regenerative Medicine

Key words: Lysozyme, Laser processing, MAPLE thin coatings, Antimicrobial surfaces, Osteoblast and endothelial cell culture [more]

Tumour-infiltrating regulatory T cell density before neoadjuvant chemoradiotherapy for rectal cancer does not predict treatment response

Melanie J. McCoy, Chris Hemmings, Chidozie C. Anyaegbu, Stephanie J. Austin, Tracey F. Lee-Pullen, Timothy J. Miller, Max K. Bulsara, Nikolajs Zeps, Anna K. Nowak, Richard A. Lake, Cameron F. Platell

Oncotarget (Impact Journals) Australia, 03 February 2017

Oncology

Key words: Rectal cancer, regulatory T cells, radiotherapy, chemotherapy, treatment response [more]

Abstract P2-04-07: Immune profiling of post neoadjuvant high metastatic risk (RCB-II/III) residual disease in patients with early triple negative breast cancers

S Irshad, M Cheang, P Gazinka, K Naidoo, R Buus, S Pinder, M Dowsett and A Tutt

Cancer Research (AACR Publications) UK, 01 February 2017

Oncology

[more]

Biocomposite coatings based on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/calcium phosphates obtained by MAPLE for bone tissue engineering

O. Rașoga, L. Sima, M. Chirițoiu, G. Popescu-Pelin, O. Fufă, d, V. Grumezescu, M. Socol, A. Stănculescu, I. Zgură, G. Socol

Applied Surface Science (Elsevier) Romania, 31 January 2017

Regenerative Medicine

Key words: MAPLE, Calcium phosphates, PHBV, Composite, Hydroxyapatite, β-Tricalcium phosphate [more]

Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes

Xianpeng Liu, Bo Zhao, Limin Sun, Karan Bhuripanyo, Yiyang Wang, Yingtao Bi, Ramana V. Davuluri, Duc M. Duong, Dhaval Nanavati, Jun Yin and Hiroaki Kiyokawa

Nature Communications (Nature) USA, 31 January 2017

Cell Biology

Key words: Protein ubiquitination, mammalian cells, polyubiquitination [more]

Effect of a cocoa diet on the small intestine and gut-associated lymphoid tissue composition in an oral sensitization model in rats ☆

Mariona Camps-Bossacoma, Francisco J. Pérez-Cano, Àngels Franch, Eva Untersmayr, Margarida Castell

Journal of Nutritional Biochemistry (Elsevier) Spain, 23 January 2017

Gastroenterology

Key words: Cholera toxin, Cocoa, Ovalbumin, TCRγδ+ cells, Tolerance [more]

SOX2 and Rb1 in esophageal small-cell carcinoma: their possible involvement in pathogenesis

Ishida H, Kasajima A, Kamei T, Miura T, Oka N, Yazdani S, Ozawa Y, Fujishima F, Sakurada A, Nakamura Y, Tanaka Y, Kurosumi M, Ishikawa Y, Okada Y, Ohuchi N, Sasano H

Modern Pathology (Nature) Japan, 20 January 2017

Pathology

Key words: Esophageal small-cell carcinoma, SOX2 overexpression, squamous-basal markers (CK5/6 and p40), glandular markers (CK18 and CEA) [more]

Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression

Monika Linke, Ha Thi Thanh Pham, Karl Katholnig, Thomas Schnöller, Anne Miller, Florian Demel, Birgit Schütz, Margit Rosner, Boris Kovacic, Nyamdelger Sukhbaatar, Birgit Niederreiter, Stephan Blüml, Peter Kuess, Veronika Sexl, Mathias Müller, Mario Mikula, Wolfram Weckwerth, Arvand Haschemi, Martin Susani, Markus Hengstschläger, Michael J Gambello and Thomas Weichhart

Nature Immunology (Nature) Austria, 16 January 2017

Pathology

Key words: Hypertrophic macrophages, tuberous sclerosis 2 (Tsc2), mTORC1 [more]

Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma

Jong Cheon Joo, Jung Hoo Hwang, Eunbi Jo, Young-Rang Kim, Dae Joon Kim, Kyung-Bok Lee, Soo Jung Park, and Ik-Soon Jang

Oncotarget (Impact Journals) South Korea, USA, 14 January 2017

Oncology

Key words: cordycepin, CAV1, JNK, Foxo3a, apoptosis [more]

Development of a DsRed-expressing HepaRG cell line for real-time monitoring of hepatocyte-like cell differentiation by fluorescence imaging, with application in screening of novel geometric microstructured cell growth substrates

Mihaela Uta,Livia E. Sima,Patrik Hoffmann,Valentina Dinca, Norica Branza-Nichita

Biomedical Microdevices (Springer) Romania, 09 January 2017

Biological Methods

Key words: HepaRG, Hepatocyte-like cells, HBV, Differentiation, Microstructured PDMS [more]

Inhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth

Elisabeth Buchberger, Dietmar Payrhuber, Miriam El Harchi, Branislav Zagrapan, Katharina Scheuba, Anna Zommer, Edina Bugyik, Balazs Dome, Julia Barbara Kral, Waltraud Cornelia Schrottmaier, Gernot Schabbauer, Peter Petzelbauer, Marion Gröger, Martin Bilban, and Christine Brostjan

Oncotarget (Impact Journals) Austria, 03 January 2017

Oncology

Key words: 79-6, Bcl-6, BCoR, colorectal carcinoma, vascular sprouting [more]

Limited tumor tissue drug penetration contributes to primary resistance against angiogenesis inhibitors

Szilvia Torok, Melinda Rezeli, Olga Kelemen, Akos Vegvari, Kenichi Watanabe, Yutaka Sugihara, Anna Tisza, Timea Marton, Ildiko Kovacs, Jozsef Tovari, Viktoria Laszlo, Thomas H. Helbich, Balazs Hegedus, Thomas Klikovits, Mir Alireza Hoda, Walter Klepetko, Sandor Paku, Gyorgy Marko-Varga, and Balazs Dome

Theranostics (NCBI) Hungary, Austria, Sweden, 01 January 2017

Oncology

Key words: matrix assisted laser desorption ionization, imaging mass spectrometry, angiogenesis, receptor tyrosine kinase inhibitor, resistance, cancer [more]

Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models

Tzu-Hsuan Wong , Hung-An Chen , Rung-Jiun Gau, Jeng-Hsien Yen, Jau-Ling Suen

PLoS One (PLOS) Taiwan, 29 December 2016

Immunology

Key words: Dendritic cells (DCs), HO-1, lipopolysaccharide (LPS), Foxp3+ [more]

Interstitial Fibrosis, Functional Status, and Outcomes in Heart Failure With Preserved Ejection Fraction

Franz Duca, Andreas A. Kammerlander, Caroline Zotter-Tufaro, Stefan Aschauer, Marianne L. Schwaiger, Beatrice A. Marzluf, Diana Bonderman, Julia Mascherbauer

Circulation:Cardiovascular Imaging (AHA Journals) Austria, 14 December 2016

Cardiology

Key words: Magnetic resonance imaging, heart failure, mapping [more]

Adipose tissue–derived mesenchymal stem cells expressing prodrug-converting enzyme inhibit human prostate tumor growth

Ilaria T Cavarretta, Veronika Altanerova, Miroslava Matuskova, Lucia Kucerova, Zoran Culig, Cestmir Altaner

Molecular Therapy (Cell Press) Austria, Slovakia, 14 December 2016

Stem Cell Research

Mesenchymal Stem Cells Correct Inappropriate Epithelial–mesenchyme Relation in Pulmonary Fibrosis Using Stanniocalcin-1

Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M

Molecular Therapy (Cell Press) Japan, 14 December 2016

Pulmonology

Key words: Mesenchymal Stem Cells, Epithelial–mesenchyme Relation, Pulmonary Fibrosis, Stanniocalcin-1 [more]

Early dissemination seeds metastasis in breast cancer

Hedayatollah Hosseini, Milan M. S. Obradović, Martin Hoffmann, Kathryn L. Harper, Maria Soledad Sosa, Melanie Werner-Klein, Lahiri Kanth Nanduri, Christian Werno, Carolin Ehrl, Matthias Maneck, Nina Patwary, Gundula Haunschild, Miodrag Gužvić, Christian Reimelt, Michael Grauvogl, Norbert Eichner, Florian Weber, Andreas D. Hartkopf, Florin-Andrei Taran, Sara Y. Brucker, Tanja Fehm, Brigitte Rack, Stefan Buchholz, Rainer Spang, Gunter Meister et al.

Nature (Nature) Germany, 14 December 2016

Oncology

Key words: Metastatic dissemination, breast cancer, HER2 , Karyotypic and phenotypic analysis [more]

Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

Dearbhaile Dooley, Evi Lemmens, Tim Vangansewinkel, Debbie Le Blon, Chloé Hoornaert, Peter Ponsaerts, Sven Hendrix

Stem Cell Reports (Elsevier) Belgium, 13 December 2016

Transplantation Medicine

Key words: Mesenchymal stem cells, interleukin-13, spinal cord injury, cell transplantation, microglia, macrophages [more]

The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells

Ghazaleh Hajmousa, Pieter Vogelaar, Linda A. Brouwer, Adrianus C. van der Graaf, Robert H. Henning, Guido Krenning

Biomaterials (Elsevier) The Netherlands, 09 December 2016

Biological Materials

Key words: Adipose tissue-derived stem cells (ASC), Hypothermia, Cold storage, Mitochondrial damage, Chromanol [more]

Involvement of Pancreatic Stellate Cells in Regeneration of Remnant Pancreas after Partial Pancreatectomy

Shigenori Ota, Miyuki Nishimura, Yuya Murakami, Naoko Kubo Birukawa, Akihiro Yoneda, Hiroki Nishita, Ryosuke Fujita, Yasushi Sato, Kenjiro Minomi, Keiko Kajiwara, Miyono Miyazaki, Maki Uchiumi, Shintaro Mikuni, Yasuaki Tamura, Toru Mizuguchi, Masafumi Imamura, Makoto Meguro, Yasutoshi Kimura, Koichi Hirata, Yoshiro Niit

PLoS One (PLOS) Japan, 09 December 2016

Regenerative Medicine

Key words: Pancreatectomy, siRNA, activated pancreas stellate cells (aPSCs), apoptosis [more]

Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

Jun Wei,Hongyan Zhu, Gabriel Lord, Mitra Bhattachayya, Brielle M. Jones, Graham Allaway, Shyam S. Biswal, Benjamin Korman, Roberta G. Marangoni, Warren G. Tourtellotte, John Varga

Translational Research (Elsevier) USA, 09 December 2016

Neuroscience

Key words: Nrf2-nuclear factor erythroid 2–related factor 2, systemic sclerosis, TGF-β, CDDO, TMC [more]

Lead-Free Piezoelectric (Ba,Ca)(Zr,Ti)O3 Thin Films for Biocompatible and Flexible Devices

N. D. Scarisoreanu, F. Craciun, V. Ion, R. Birjega, A. Bercea V. Dinc, M. Dinescu, L. E. Sima, M. Icriverzi, A. Roseanu, L. Gruionu, and G. Gruionu

Applied Materials and Interfaces (ACS Publications) Romania, 08 December 2016

Biological Materials

Key words: Biocompatible materials, laser processing, lead-free thin films, mesenchymal stem cells, osteogenic differentiation [more]

Silica-Coated Metal Chelating-Melanin Nanoparticles as a Dual-Modal Contrast Enhancement Imaging and Therapeutic Agent

Soojeong Cho, Wooram Park and Dong-Hyun Kim

Applied Materials and Interfaces (ACS Publications) USA, 08 December 2016

Nanomedicine

Key words: Fluorescence imaging, melanin, metal-chelation, MRI, multimodal image-guidance, silica coating [more]

Nodal metastasis signatures in breast cancer

Kyeongmee ParK, Joo Hyun Lee, Hyun Ho Han, Seong Gyeong Mun, Suki Kang, Youn Jin Cha, Ja-Seung Koo, Min Ju Kim, Hye Sun Lee, Jieun Moon, Nam Hoon Cho

Pathology - Research and Practice (Elsevier) South Korea, 05 December 2016

Oncology

Key words: Breast cancer, node positive ratio, node positive number, ERK, WDR1, c-MET [more]

Solid stress and elastic energy as measures of tumour mechanopathology

Hadi T. Nia, Hao Liu, Giorgio Seano, Meenal Datta, Dennis Jones, Nuh Rahbari, Joao Incio, Vikash P. Chauhan, Keehoon Jung, John D. Martin, Vasileios Askoxylakis, Timothy P. Padera, Dai Fukumura, Yves Boucher, Francis J. Hornicek, Alan J. Grodzinsky, James W. Baish, Lance L. Munn and Rakesh K. Jain

Nature Biomedical Engineering (Nature) USA, 28 November 2016

Neuroscience

Key words: Solid stress, tissue stiffness, tumour [more]

Mast Cells Are Abundant in Primary Cutaneous T-Cell Lymphomas: Results from a Computer-Aided Quantitative Immunohistological Study

Johanna Eder , Radu Rogojanu, Waltraud Jerney, Friedrich Erhart, Alexander Dohnal, Melitta Kitzwögerer, Georg Steiner, Julia Moser, Franz Trautinger

PLoS One (PLOS) Austria, 28 November 2016

Oncology

Key words: Mast cells, cutaneous T-cell lymphomas (CTCL), haematopoetic cells [more]

Cardiac extracellular matrix is associated with adverse outcome in patients with chronic heart failure

Franz Duca,Caroline Zotter-Tufaro,Andreas A. Kammerlander,Adelheid Panzenböck,Stefan Aschauer,Daniel Dalos,Benedikt Köll,Benedikt Börries,Hermine Agis,Renate Kain,Klaus Aumayr,Florian Klinglmüller,Julia Mascherbauer,Diana Bonderman

European Journal of Heart Failure (Wiley) Austria, 27 November 2016

Cardiology

Key words: Extracellular matrix (ECM), heart failure (HF), endomyocardial biopsy [more]

Antimicrobial polycaprolactone/ polyethylene glycol embedded lysozyme coatings of Ti implants for osteoblast functional properties in tissue engineering

A. Visan, R. Cristescu, N. Stefan, M. Miroiu, C. Nita, M. Socol, C. Florica, O. Rasoga, I. Zgura, L.E. Sima, M. Chiritoiu, M.C. Chifiriuc, A.M. Holban, I.N. Mihailescu, G. SocoL

Applied Surface Science (Elsevier) Romania, 19 November 2016

Immunology

Key words: MAPLE, Dip coating, Lysozyme, Blends, Antimicrobial, Biocompatible [more]

Rhinophototherapy in persistent allergic rhinitis

Zsolt Bella, Ágnes Kiricsi, Éva Dósa-Rácz Viharosné, Attila Dallos, Ádám Perényi, Mária Kiss, Andrea Koreck, Lajos KeményJózsef JóriLászló Rovó, Edit Kadocsa

European Archives of Oto-Rhino-Laryngology (Springer) Hungary, 18 November 2016

Allergy Research

Key words: Intercellular adhesion molecule-1 expression, Intranasal phototherapy, Mucociliary clearance, Nasal inspiratory peak flow, Persistent allergic rhinitis, Rhinolight [more]

The plasma membrane Ca2+ pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells

Luca Hegedũs,Tamás Garay,Eszter Molnár,Karolina Varga,Ágnes Bilecz,Szilvia Török,Rita Padányi,Katalin Pászty,Matthias Wolf,Michael Grusch,Enikõ Kállay,Balázs Döme,Walter Berger,Balázs Hegedũs,Agnes Enyedi

International Journal of Cancer (Wiley) Austria, 17 November 2016

Oncology

Key words: Ca2+, PMCA4b expression, NRAS mutant melanoma cells [more]

Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Debbie Le Blon, Caroline Guglielmetti, Chloé Hoornaert, Alessandra Quarta, Jasmijn Daans, Dearbhaile Dooley, Evi Lemmens, Jelle Praet, Nathalie De Vocht, Kristien Reekmans, Eva Santermans, Niel HensHerman Goossens, Marleen Verhoye, Annemie Van der Linden, Zwi Berneman, Sven Hendrix, Peter Ponsaerts

Journal of Neuroinflammation (Springer) Belgium, 09 November 2016

Neuroscience

Key words: Interleukin 13, Mesenchymal stem cells, Neuroinflammation, Transplantation, Magnetic resonance imaging [more]

Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis

Yi-Ching Wang, Hong-Tai Tzeng, Chung-Han Tsai, Yi-Ting Yen, Hung-Chi Cheng, Yi-Chieh Chen, Shih-Wen Pu, Yu-Shiuan Wang, Yan-Shen Shan, Yau-Lin Tseng, Wu-Chou Su, Wu-Wei Lai and Li-Wha Wu

Clinical Cancer Research (AACR Publications) Taiwan, 07 November 2016

Oncology

Key words: Rab37-Mediated, Thrombospondin-1, angiogenesis marker CD31, p-FAK/p-paxillin/p-ERK [more]

Asxl2−/− Mice Exhibit De Novo Cardiomyocyte Production during Adulthood

R Brunner, HL Lai, Z Deliu, E Melman, DL Geenen, QT Wang

Journal of Developmental Biology (MDPI) USA, 03 November 2016

Reproductive Medicine

Key words: heart, cardiogenic, cardiomyocyte, proliferation, regeneration, chromatin factor, epigenetic [more]

A Single Postnatal Dose of Dexamethasone Enhances Memory of Rat Pups Later in Life

Kuen-Jer Tsai , Chun-I Sze , Yung-Chieh Lin, Yuh-Jyh Lin, Ting-Hui Hsieh, Chyi-Her Lin

PLoS One (PLOS) Taiwan, 31 October 2016

Neuroscience

Key words: Postnatal dexamethasone (Dex) therapy, NMDAR, bronchopulmonary dysplasia, chronic lung disease [more]

Cell Line Macroarray: An Alternative High-Throughput Platform to Analyze hiPSC Lines

Alberto La Spada, Simona Baronchelli, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Nunzia Convertino, Aikaterini Ntai, Tobias Steiner, Ida Biunno, Andrea De Blasio

Journal of Histochemistry and Cytochemistry (SAGE Journals) Italy, Austria, 26 October 2016

Biological Methods

Key words: cell line macroarray, high-throughput screening and quantification, hiPSC clones [more]

An Alternative High-Throughput Platform to Analyze hiPSC Lines

Alberto La Spada, Simona Baronchelli, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Nunzia Convertino, Aikaterini Ntai, Tobias Steiner, Ida Biunno, Andrea De Blasio

Journal of Histochemistry and Cytochemistry (SAGE Journals) Italy, Austria, 26 October 2016

Biological Methods

Key words: Cell line macroarray, high-throughput screening and quantification, hiPSC clones [more]

Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle

Tim Koopmans,Stijn Crutzen,Mark H Menzen,Andrew J Halayko,Tillie-Louise Hackett,Darryl A Knight,Reinoud Gosens

British Journal of Pharmacology (Wiley) USA, The Netherlands, 25 October 2016

Pharmacology

Key words: Asthma, β-catenin, CREB-binding protein (CBP) , TGFβ1 [more]

KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1

Yu Gao, Hongzhao Li, Xin Ma, Yang Fan, Dong Ni, Yu Zhang, Qingbo Huang, Kan Liu, Xintao Li, Lei Wang, Liangyou Gu, Yuanxin Yao, Qing Ai, Qingshan Du, Erlin Song and Xu Zhang

Molecular Cancer Research (AACR Publications) China, 25 October 2016

Oncology

Key words: KLF6 expression, E2F1-mediated epithelial–mesenchymal, cell renal cell carcinoma (ccRCC) [more]

TRPV1 attenuates intracranial arteriole remodeling through inhibiting VSMC phenotypic modulation in hypertension

MJ Zhang, Y Liu, ZC Hu, Y Zhou, Y Pi, L Guo, X Wang, X Chen, JC Li, LL Zhang

Histochemistry and Cell Biology (Springer) China, 24 October 2016

Cardiology

Key words: TRPV1, Intracranial arteriole, VSMC, Phenotypic modulation, Hypertension [more]

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

Brasó-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, Plumb DA, Zakka L, Gazinska P, Liccardi G, Meier P, Gris-Oliver A, Cheang MC, Perdrix-Rosell A, Shafat M, Noël E, Patel N, McEachern K, Scaltriti M, Castel P, Noor F, Buus R, Mathew S, Watkins J, Serra V, Marra P, Grigoriadis A, Tutt AN

Nature Medicine (Nature) UK, 24 October 2016

Oncology

Key words: Triple-negative breast cancers (TNBCs), PIM1 proto-oncogene, anti-apoptotic factor BCL2, dynamic BH3 [more]

Oncolytic influenza A virus expressing interleukin-15 decreases tumor growth in vivo 

Karin Hock, Johannes Laengle, Irina Kuznetsova,Andrej Egorov, Balazs Hegedus, Balazs Dome, Thomas Wekerle, Monika Sachet, Michael Bergmann

Surgery (Elsevier) Austria, 21 October 2016

Immunology

Key words: Interleukin-15, A virus, T cells, [more]

The fractionation of adipose tissue procedure to obtain stromal vascular fractions for regenerative purposes

Joris A. van Dongen,Hieronymus P. Stevens ,Mojtaba Parvizi ,Berend van der Lei ,Martin C. Harmsen

Wound Repair and Regeneration (Wiley) The Netherlands, 21 October 2016

Regenerative Medicine

Key words: Autologous adipose tissue transplantation, FAT-stromal vascular fraction [more]

Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury

Jill Moser, Joris van Ark, Marcory C. van Dijk, Dale L. Greiner, Leonard D. Shultz, Harry van Goor and Jan-Luuk Hillebrands

Scientific Reports (Nature) USA, The Netherlands, 19 October 2016

Cardiology

Key words: NOD.Cg-PrkdcscidIL2rgtm1Wjl(NSG), Percutaneous coronary interventions (PCIs), BL/6 mice [more]

In Situ Characterization of Tissue-Resident Immune Cells by MALDI Mass Spectrometry Imaging

Matthias Holzlechner, Katharina Strasser, Elitsa Zareva, Luise Steinhäuser, Hanna Birnleitner, Andrea Beer, Michael Bergmann, Rudolf Oehler, and Martina Marchetti-Deschmann

Journal of Proteome Research (ACS Publications) Austria, 18 October 2016

Immunology

Key words: Colon tissue, immune cells, immunohistochemistry, lymphocytes, macrophages, MALDI mass spectrometry imaging, monocytes [more]

Aberrant expression of tumor-associated carbohydrate antigen Globo H in thyroid carcinoma

Shih-Ping Cheng ,Po-Sheng Yang ,Ming-Nan Chien ,Ming-Jen Chen ,Jie-Jen Lee ,Chien-Liang Liu

Journal of Surgical Oncology (Wiley) Taiwan, 18 October 2016

Oncology

Key words: Globo H - hexasaccharide glycosphingolipid, Normal or benign thyroid, papillary thyroid cancer [more]

Oncostatin M‐preconditioned mesenchymal stem cells alleviate bleomycin‐induced pulmonary fibrosis through paracrine effects of the hepatocyte growth factor

Ying‐Wei Lan, Si‐Min Theng, Tsung‐Teng Huang, Kong‐Bung Choo, Chuan‐Mu Chen, Han‐Pin Kuo, Kowit‐Yu Chong

Stem Cells Translational Medicine (Wiley) Taiwan, Malaysia, 18 October 2016

Stem Cell Research

Key words: Bleomycin-induced pulmonary fibrosis, Hepatocyte growth factor, Oncostatin M, Preconditioning, Stem cells [more]

Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha TT Pham, Maximilian Kauer, Rahil Noorizadeh, Barbara Sax, Harini Nivarthi, Michaela Schlederer, Barbara Maurer, Maximillian Hofbauer, Dave NT Aryee, Marc Wiedner, Eleni M Tomazou, Malcolm Logan, Christine Hartmann, Jan P Tuckermann, Lukas Kenner, Mario Mikula, Helmut Dolznig, Aykut Üren, Günther H Richter, Florian Grebien, Heinrich Kovar and Richard Moriggl

Cell Death & Disease (Nature) Austria, UK, Germany, 13 October 2016

Oncology

Key words: Apoptosis, Bone cancer, Cell signalling, Sarcoma [more]

Ustekinumab treatment in severe atopic dermatitis: Down-regulation of T-helper 2/22 expression 

Doris Weiss, Michaela Schaschinger, Robin Ristl, Robert Gruber, Tamara Kopp, Georg Stingl, Christine Bangert

Journal of the American Academy of Dermatology (Elsevier) Austria, 13 October 2016

Dermatology

Key words: Anti-interleukin-12/-23 p40, atopic dermatitis, cytokines, eczema, inflammatory, T helper 2, T helper 17, T helper 22, ustekinumab [more]

Intraarticular overexpression of Smad7 ameliorates experimental arthritis

Shih-Yao Chen, Ai-Li Shiau, Chao-Liang Wu and Chrong-Reen Wang

Scientific Reports (Nature) Taiwan, 12 October 2016

Immunology

Key words: Genetic vectors, Translational immunology [more]

Hydroxyapatite thin films grown by pulsed laser deposition and matrix assisted pulsed laser evaporation: Comparative study

G. Popescu-Pelin, F. Sima, L.E. Sima, C.N. Mihailescu, C. Luculescu, I. Iordache, M. Socol, G. Socol, I.N. Mihailescu

Applied Surface Science (Elsevier) Romania, 11 October 2016

Regenerative Medicine

Key words: Pulsed laser deposition, Matrix assisted pulsed laser evaporation, Hydroxyapatite coatings, Biocompatibility, Cell proliferation and differentiation [more]

Neuronal prolyl-4-hydroxylase 2 deficiency improves cognitive abilities in a murine model of cerebral hypoperfusion

Daniel Gruneberg, Felipe A. Montellano, Konstanze Plaschke, Lexiao Li, Hugo H. Marti, Reiner Kunze

Experimental Neurology (Elsevier) Germany, 05 October 2016

Neuroscience

Key words: HIF, PHD, Epo, VEGF, Hippocampus, Learning, Memory, Alzheimer's disease [more]

G-CSF-mobilized Bone Marrow Mesenchymal Stem Cells Replenish Neural Lineages in Alzheimer’s Disease Mice via CXCR4/SDF-1 Chemotaxis

Cheng-Chun WuI-Fang Wang, Po-Min Chiang, Liang-Chao Wang, Che-Kun James Shen, Kuen-Jer Tsai

Molecular Neurobiology (Springer) Taiwan, 05 October 2016

Neuroscience

Key words: G-CSF, Bone marrow stem cells, SDF-1CXCR4, Neurogenesis, Alzheimer’s disease [more]

Epithelial cholesterol deficiency attenuates human antigen R-linked pro-inflammatory stimulation via SREBP2-linked circuit

SH Park, J Kim, M Yu, JH Park, YS Kim, Y Moon

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) South Korea, 04 October 2016

Gastroenterology

Key words: cholesterol regulation, inflammation, intestinal epithelium, intestinal metabolism, intestine, mRNA decay [more]

Houttuynia cordata Thunb Promotes Activation of HIF-1A–FOXO3 and MEF2A Pathways to Induce Apoptosis in Human HepG2 Hepatocellular Carcinoma Cells

Jung Min Kim, In-Hu Hwang, Ik-Soon Jang, Min Kim, In Seok Bang, Soo Jung Park, Yun-Jo Chung, Jong-Cheon Joo, Min-Goo Lee

Integrative Cancer Therapies (SAGE Journals) South Korea, 03 October 2016

Oncology

Key words: Cancer, cell apoptosis, hypoxia-inducible factor (HIF)-1A [more]

Hyperglycemia induces bioenergetic changes in adipose-derived stromal cells while their pericytic function is retained

Ghazaleh Hajmousa, Alvaro A. Elorza, Vera J.M. Nies, Erik L. Jensen, Ruxandra A. Nagy, and Martin C. Harmsen

Stem Cells and Development (Mary Ann Liebert Inc.) The Netherlands, Chile, 01 October 2016

Stem Cell Research

Key words: Adipose Derived Stromal Cells, Diabetic Retinopathy, Pericyte, Hyperglycemia [more]

NSAID-activated gene 1 mediates pro-inflammatory signaling activation and paclitaxel chemoresistance in type I human epithelial ovarian cancer stem-like cells

KH Kim, SH Park, KH Do, J Kim, KU Choi, Y Moon

Histochemistry and Cell Biology (NCBI) South Korea, 30 September 2016

Oncology

Key words: NAG-1, epithelial ovary cancer, paclitaxel, NF-κB, chemoresistance [more]

Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Caroline Guglielmetti,Debbie Le Blon, Eva Santermans, Angelica Salas-Perdomo, Jasmijn Daans, Nathalie De Vocht, Disha Shah, Chloé Hoornaert, Jelle Praet, Jurgen Peerlings, Firat Kara, Christian Bigot, Zhenhua Mai, Herman Goossens, Niel Hens, Sven Hendrix, Marleen Verhoye, Anna M. Planas, Zwi Berneman, Annemie van der Linden, Peter Ponsaerts

GLIA (Wiley) Belgium, 29 September 2016

Neuroscience

Key words: IL-13, microglia, macrophages, severe oligodendrocyte loss and demyelination, mouse nodel [more]

Comparison of cancer cells cultured in 2D vs 3D reveals differences in AKT/mTOR/S6-kinase signaling and drug response

Angelika Riedl, Michaela Schlederer, Karoline Pudelko, Mira Stadler, Stefanie Walter, Daniela Unterleuthner, Christine Unger, Nina Kramer, Markus Hengstschläger, Lukas Kenner, Dagmar Pfeiffer, Georg Krupitza, Helmut Dolznig

Journal of Cell Science (The Company of Biologists) Austria, 23 September 2016

Oncology

Key words: Cancer cells, colon cancer, AKT/mTOR/S6-kinase, ERK phosphorylation [more]

Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance

Joonseok Lee, Andrew C. Gordon, Hacksung Kim, Wooram Park, Soojeong Cho, Byeongdu Lee, Andrew C. Larson, Elena A. Rozhkova, Dong-Hyun Kim

Biomaterials (Elsevier) USA, 19 September 2016

Medical Imaging

Key words: Upconversion nanoparticles, Medical imaging, Cancer, Interventional radiology, Multimodal probe [more]

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy

Fenne L. Komdeur, Maartje C.A. Wouters, Hagma H. Workel, Aline M. Tijans, Anouk L.J. Terwindt, Kim L. Brunekreeft, Annechien Plat, Harry G. Klip, Florine A. Eggink, Ninke Leffers, Wijnand Helfrich, Douwe F. Samplonius, Edwin Bremer, G. Bea A. Wisman, Toos Daemen, Evelien W. Duiker, Harry Hollema, Hans W. Nijman and Marco de Bruyn

Oncotarget (Impact Journals) The Netherlands, 16 September 2016

Oncology

Key words: tumor-infiltrating lymphocytes, high-grade serous ovarian cancer, CD103, TGF-β, cancer immunotherapy [more]

Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Seunggu J. Han, Gerald Reis, Gary Kohanbash, Shruti Shrivastav, Stephen T. Magill, Annette M. Molinaro, Michael W. McDermott, Philip V. Theodosopoulos, Manish K. Aghi, Mitchel S. Berger, Nicholas A. Butowski, Igor Barani, Joanna J. Phillips, Arie Perry, Hideho Okada

Journal of Neuro-Oncology (Springer) USA, 13 September 2016

Neuroscience

Key words: Meningioma, PD-L1, B7-H1, Immunotherapy, Checkpoint, Lymphocyte, Macrophage [more]

Paricalcitol attenuates cardiac fibrosis and expression of endothelial cell transition markers in isoproterenol-induced cardiomyopathic rats

CC Lai, CP Liu, PW Cheng, PJ Lu, M Hsiao, WH Lu, GC Sun, JC Liou, CJ Tseng

Critical Care Medicine (Ingentaconnect) Taiwan, 09 September 2016

Cardiology

Key words: cardiac fibrosis, cardiomyopathy, endothelial-to-mesenchymal cell transition, vitamin D activator [more]

The effects of oral and topical corticosteroid in rabbit corneas

Kaoru Araki-Sasaki, Osamu Katsuta, Hidetoshi Mano, Takashi Nagano and Masatsugu Nakamura

BMC Ophthalmology (BioMed Central) Japan, 05 September 2016

Ophthalmology

Key words: Corticosteroid, Keratitis, Cornea, Wound healing, Pharmacokinetics [more]

Presentation of underglycosylated mucin 1 in pancreatic adenocarcinoma (PDAC) at early stages

ST Lo, P Pantazopouos, Z Medarova, A Moore

American Journal of Cancer Research (NCBI) USA, 01 September 2016

Oncology

Key words: Pancreatic cancer, underglycosylated mucin 1, tumor antigen, immunohistochemistry [more]

Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation

Yong-Hee Rhee, Sang-Hoon Yi, Joo Yeon Kim, Mi-Yoon Chang, A-Young Jo, Jinyoung Kim, Chang-Hwan Park, Je-Yoel Cho, Young-Jin Choi, Woong Sun and Sang-Hun Lee

Scientific Reports (Nature) South Korea, 24 August 2016

Neuroscience

Key words: Neurology, neural stem cells, Raf-Erk pathway, radial glial cells [more]

Degradation of Kidney and Psoas Muscle Proteins as Indicators of Post-Mortem Interval in a Rat Model, with Use of Lateral Flow Technology

Dong-Gi Lee, Kyeong Eun Yang, Jeong Won Hwang, Hwan-Soo Kang, Seung-Yeul Lee, Seoyeon Choi, Joonchul Shin, Ik-Soon Jang, Hyun Joo An, Heesun Chung, Hyo-Il Jung , Jong-Soon Choi

PLoS One (PLOS) South Korea, 23 August 2016

Forensic Science

Key words: Post-mortem interval (PMI) markers, kidney, muscle, GAPDH [more]

Toward the Automated Detection and Characterization of Osteoclasts in Microscopic Images

Andreas Heindl , Martin Schepelmann, Robert Nica, Rupert Ecker, Peter Pietschmann, Alexander K. Seewald, Theresia Thalhammer, Isabella Ellinger

Principles of Osteoimmunology (Springer) Austria, 19 August 2016

Medical Image Analysis

Key words: Osteoimmunology, microscopes, biological samples, automated image segmentation and analysis

LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson’s disease model

Yong-Hee Rhee, Tae-Ho Kim, A-Young Jo, Mi-Yoon Chang, Chang-Hwan Park, Sang-Mi Kim, Jae-Jin Song, Sang-Min Oh, Sang-Hoon Yi, Hyeon Ho Kim, Bo-Hyun You, Jin-Wu Nam, Sang-Hun Lee

Brain: A journal of neurology (Oxford University Press) South Korea, 18 August 2016

Neuroscience

Key words: LIN28A, neural stem cell (NSC) culture, repair capacity, Parkinson’s disease [more]

Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia

Somayyeh Hamzei Taj, Widuri Kho, Markus Aswendt, Franziska M. Collmann, Claudia Green, Joanna Adamczak, Annette Tennstaedt, Mathias Hoehn

Journal of Neuroimmune Pharmacology (Springer) Germany, 18 August 2016

Neuroscience

Key words: Stroke, Microglia/macrophage polarization, Pro-inflammatory and anti-inflammatory phenotypes, miRNA-124, Neuroinflammation [more]

The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase (MAPK) signaling

Finny S. Varghese, Bastian Thaa, Siti Naqiah Amrun, Diane Simarmata, Kai Rausalu, Tuula A. Nyman, Andres Merits, Gerald M. McInerney2, Lisa F.P. Ng, Tero Ahola

Journal of Virology (American Society for Microbiology) Finland, 17 August 2016

Virology

Key words: Chikungunya virus, non-toxic plant alkaloid berberine, mitogen-activated protein kinase [more]

Bradykinin promotes neuron-generating division of neural progenitor cells via ERK activation

Micheli M. Pillat, Claudiana Lameu, Cleber A. Trujillo, Talita Glaser, Angélica R. Cappellari, Priscilla D. Negraes, Ana M. O. Battastini, Telma T. Schwindt, Alysson Muotri, Henning Ulrich

Journal of Cell Science (The Company of Biologists) Brazil, 15 August 2016

Neuroscience

Key words: Bradykinin, neurogenesis, TIS21 (PC3/BTG2) expression [more]

G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway

Shih-Ting Cha, Ching-Ting Tan, Cheng-Chi Chang, Chia-Yu Chu, Wei-Jiunn Lee, Been-Zen Lin, Ming-Tsan Lin and Min-Liang Kuo

Nature Cell Biology (Nature) Taiwan, 15 August 2016

Oncology

Key words: Colorectal cancer, cancer-initiating cells phenotypes, K-RAS/β-catenin pathway [more]

Prevention of Colitis and Colitis-Associated Colorectal Cancer by a Novel Polypharmacological Histone Deacetylase Inhibitor

Tzu-Tang Wei, Yi-Ting Lin, Ruo-Yu Tseng, Chia-Tung Shun, Yu-Chin Lin, Ming-Shiang Wu, Jim-Min Fang, Ching-Chow Chen

Clinical Cancer Research (AACR Publications) Taiwan, 14 August 2016

Oncology

Key words: Colorectal cancer, colitis, HDAC, HMGR [more]

Localization of TrkB and p75 receptors in peritoneal and deep infiltrating endometriosis: an immunohistochemical study

Agung Dewanto, Jozsef Dudas, Rudolf Glueckert, Sylvia Mechsner, Anneliese Schrott-Fischer, Ludwig Wildt and Beata Seeber

Reproductive Biology and Endocrinology (Springer) Germany, 12 August 2016

Reproductive Medicine

Key words: Neurotrophins,  BDNF,  endometriosis,  immunohistochemistry [more]

Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

Bethany Baumann , Tomoko Hayashida, Xiaoyan Liang, H. William Schnaper

Kidney International (Elsevier) USA, 05 August 2016

Physiology

Key words: Fibrosis, glomerulus, hypoxia, TGF-β [more]

Role of the immune system in the peritoneal tumor spread of high grade serous ovarian cancer

Katharina Auer, Anna Bachmayr-Heyda, Nyamdelger Sukhbaatar, Stefanie Aust, Klaus G. Schmetterer, Samuel M. Meier, Christopher Gerner, Christoph Grimm, Reinhard Horvat, and Dietmar Pils

Oncotarget (Impact Journals) Austria, 03 August 2016

Oncology

Key words: epithelial ovarian cancer, peritoneal tumor spread, flow cytometry, PD-1, next generation sequencing [more]

Sur8 mediates tumorigenesis and metastasis in colorectal cancer

Young-Mi Lee, Saluja Kaduwal, Kug Hwa Lee, Jong-Chan Park, Woo-Jeong Jeong, Kang-Yell Choi

Experimental and Molecular Medicine (Nature) South Korea, 29 July 2016

Oncology

Key words: Scaffold protein, Ras-extracellular signal-regulated kinase, doxycyline, HCT116 cells [more]

CD271 regulates the proliferation and motility of hypopharyngeal cancer cells

Mai Mochizuki, Keiichi Tamai, Takayuki Imai, Sayuri Sugawara, Naoko Ogama, Mao Nakamura, Kazuto Matsuura, Kazunori Yamaguchi, Kennichi Satoh, Ikuro Sato, Hozumi Motohashi, Kazuo Sugamura, Nobuyuki Tanaka

Scientific Reports (Nature) Japan, 29 July 2016

Oncology

Key words: CD271 (p75 neurotrophin receptor), human hypopharyngeal cancer, head and neck squamous cell carcinoma [more]

Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction

Tim Koopmans, Kuldeep Kumawat, Andrew J Halayko, Reinoud Gosens

Scientific Reports (Nature) The Netherlands, 29 July 2016

Cell Biology

Key words: Airway hyperresponsiveness, asthm, intracellular calcium flux, actin polymerisation [more]

Tissue-Resident CD169+ Macrophages Form a Crucial Front Line against Plasmodium Infection

Pravesh Gupta, Si Min Lai, Jianpeng Sheng, Piotr Tetlak, Akhila Balachander, Carla Claser, Laurent Renia, Klaus Karjalainen, Christiane Ruedl

Cell Reports (Cell Press) Singapore, 28 July 2016

Cell Biology

Key words: Plasmodium berghei ANKA, malaria, myeloid cells, macrophages [more]

In situ mapping of innate lymphoid cells in human skin: evidence for remarkable differences between normal and inflamed skin

Marie-Charlotte Brüggen, Wolfgang M. Bauer, Bärbel Reininger, Eduard Clim, Catalin Captarencu Georg E. Steiner, Patrick M. Brunner, Barbara Meier, Lars E. French, Georg Sting

Journal of Investigative Dermatology (Elsevier) Austria, Switzerland, Romania, 22 July 2016

Dermatology

Key words: Lymphoid Cells, Human Skin, Inflamed Skin, atopic dermatitis, psoriasis [more]

4 – Proffered Paper: Immunological changes during tumor progression from primary to recurrent glioblastoma

C. Herold-Mende, C. Rapp, R. Warta, A. Unterberg, P. Beckhove

European Journal of Cancer (Elsevier) , 14 July 2016

Oncology

Key words: Cancer, tumor, glioblastoma [more]

Multimodal Imaging of Nanocomposite Microspheres for Transcatheter Intra-Arterial Drug Delivery to Liver Tumors

Dong-Hyun Kim, Weiguo Li, Jeane Chen, Zhuoli Zhang, Richard M. Green, Sui Huang and Andrew C. Larson

Scientific Reports (Nature) USA, 13 July 2016

Oncology

Key words: Biomedical materials, cancer imaging, hepatic artery, nanotechnology in cancer, targeted therapies [more]

Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor β2 immunohistochemistry in prostate cancer

Anthony E. Rizzardi, Xiaotun Zhang, Rachel Isaksson Vogel, Suzanne Kolb, Milan S. Geybels, Yuet-Kin Leung, Jonathan C. Henriksen, Shuk-Mei Ho, Julianna Kwak, Janet L. Stanford, and Stephen C. Schmechel

Diagnostic Pathology (BioMed Central) USA, 11 July 2016

Pathology

Key words: Prostate cancer, Biomarkers, Digital pathology, Quantification, Estrogen receptor β2 [more]

Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice

Dominic Schmidt, Daniel Peterlik, Stefan O. Reber, Anja Lechner, Daniela N. Männel

PLoS One (PLOS) Germany, 08 July 2016

Neuroscience

Key words: Chronic subordinate colony, myeloid cells, hypothalamus-pituitary-adrenal, sympathetic nervous system [more]

Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis

Takashi Maehara, Hamid Mattoo, Miho Ohta, Vinay S Mahajan, Masafumi Moriyama, Masaki Yamauchi, Jefte Drijvers, Seiji Nakamura, John H Stone, Shiv S Pillai

Annals of the Rheumatic Diseases (BMJ Journals) Japan, 29 June 2016

Rheumatology

Key words: IgG4-related disease, T lymphocytes, Sjögren's syndrome, [more]

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

Hweixian Leong Penny, Je Lin Sieow, Giulia Adriani, Wei Hseun Yeap, Peter See Chi Ee, Boris San Luis, Bernett Lee, Terence Lee, Shi Ya Mak, Ying Swan Ho, Choon Kiat Ong, Ruby Y J Huang, Florent Ginhoux, Olaf Rotzschke, Roger D. Kamm and Siew, Cheng Wong

OncoImmunology (Taylor and Francis) Singapore, 21 June 2016

Oncology

Key words: Metabolism, macrophages, pancreatic cancer, metastasis [more]

ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments

Rick Conzemius, Haleh Ganjian, Dieter Blaas and Renate Fuchs

Journal of Virology (American Society for Microbiology) Austria, 20 June 2016

Virology

Key words: Human rhinovirus A89 (HRV-A89) and HRV-B14, RNA genome, endocytic recycling compartment (ERC) [more]

Validation of tumor protein marker quantification by two independent automated immunofluorescence image analysis platforms

Amy R Peck, Melanie A Girondo, Chengbao Liu, Albert J Kovatich, Jeffrey A Hooke, Craig D Shriver, Hai Hu, Edith P Mitchell, Boris Freydin, Terry Hyslop, Inna Chervoneva and Hallgeir Rui

Modern Pathology (Nature) USA, 17 June 2016

Medical Image Analysis

Key words: Histology, biomarkers, breast tumor

Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Chen-Chi Liu, Shih-Pei Lin, Han-Shui Hsu, Shung-Haur Yang, Chiu-Hua Lin, Muh-Hwa Yang, Mien-Chie Hung and Shih-Chieh Hung

Nature Communications (Nature) Taiwan, 16 June 2016

Oncology

Key words: Biological sciences, cancer, cell biology [more]

A new fluorescence/PET probe for targeting intracellular human telomerase reverse transcriptase (hTERT) using Tat peptide-conjugated IgM

Kyung oh Jung, Hyewon Youn , Seung Hoo Kim, Young-Hwa Kim, Keon Wook Kang, June-Key Chunga

Biochemical and Biophysical Research Communications (Elsevier) South Korea, 15 June 2016

Biological Methods

Key words: Intracellular and intranuclear protein, hTERT, tat peptide, IgM antibody, 64Cu, Live cell imaging [more]

Ribosome inactivation leads to attenuation of intestinal polymeric Ig receptor expression via differential regulation of human antigen R

KH Do, SH Park, J Kim, M Yu, Y Moon

The Journal of Immunology (American Association of Immunologists) South Korea, 15 June 2016

Immunology

Key words: Ribosome , Polymeric Ig Receptor , Differential Regulation, Human Antigen R [more]

Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine

Norihiro Kishida, Sachiko Matsuda, Osamu ItanoEmail author, Masahiro Shinoda, Minoru Kitago,Hiroshi Yagi, Yuta Abe, Taizo Hibi, Yohei Masugi, Koichi Aiura, Michiie Sakamoto and Yuko Kitagawa

BMC Gastroenterology (BioMed Central) Japan, 13 June 2016

Oncology

Key words: Nonalcoholic steatohepatitis, hepatocellular carcinoma, diethylnitrosamine, high-fat choline-deficient diet, mouse model [more]

Automated muscle fiber type population analysis with ImageJ of whole rat muscles using rapid myosin heavy chain immunohistochemistry

Konstantin D. Bergmeister, Marion Gröger, Martin Aman, Anna Willensdorfer, Krisztina Manzano-Szalai, Stefan Salminger and Oskar C. Aszmann

Muscle and Nerve (Wiley) Austria, 13 June 2016

Medical Image Analysis

Key words: Automated muscle fiber analysis, fiber population, ImageJ, muscle fiber type, myosin heavy chain, rat [more]

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Pu-Hyeon Cha, Yong-Hee Cho, Sang-Kyu Lee, JaeHeon Lee, Woo-Jeong Jeong, Byoung-San Moon, Ji-Hye Yun, Jee Sun Yang, Sooho Choi, Juyong Yoon, Hyun-Yi Kim, Mi-Yeon Kim, Saluja Kaduwal, Weontae Lee, Do Sik Min, Hoguen Kim, Gyoonhee Han and Kang-Yell Choi

Nature Chemical Biology (Nature) South Korea, 13 June 2016

Oncology

Key words: Cancer therapy, cell signalling, screening, small molecules [more]

Clonorchis sinensis omega-class glutathione transferases play major roles in the protection of the reproductive system during maturation and the response to oxidative stress

Jeong-Geun Kim, Chun-Seob Ahn, Seon-Hee Kim, Young-An Bae, Na-Young Kwon, Insug Kang, Hyun-Jong Yang, Woon-Mok Sohn, Yoon Kong

Parasites and Vectors (BioMed Central) South Korea, 13 June 2016

Parasitology

Key words: Clonorchis sinensis, glutathione transferase (GST), omega-class GST, sexual maturation, reproductive system, oxidative stress [more]

Amniotic Fluid Cells Proliferation in Normal and Down Syndrome Subjects

A Honcea, R Iulian, AG Pavel, I Ion, LE Sima

ARS Medica Tomitana (Sciendo) Romania, 11 June 2016

Reproductive Medicine

Key words: Down syndrome, Trisomy 21, amniotic fluid-derived stem cells, proliferation, cell cycle [more]

Epidermal desmoglein 1 expression is reduced in kidney transplant recipients compared to immunocompetent patients

Jodi L. Johnson, Paul Hoover, Borko D. Jovanovic, Kathleen J. Green, John J. Friedewald, June K. Robinson

Journal of Investigative Dermatology (Elsevier) USA, 11 June 2016

Dermatology

Key words: Calcineurin inhibitor, desmoglein, E-cadherin, epidermal growth factor receptor, histone deacetylase inhibitor, immunocompetent patient, K1/10, Keratin 1 or 10, kidney transplant recipient, mycophenolate mofitil, plakoglobin, squamous cell carcinoma, ultraviolet light [more]

ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Amy M. Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V. Misharin, FuNien Tsai, G. Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E. Vaughan, Carla M. Cuda and Harris Perlman

Journal of Translational Medicine (BioMed Central) USA, 10 June 2016

Immunology

Key words: Arthritis, cholesterol, inflammation, animal models of human disease [more]

Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang

Molecular Cancer (Springer) Taiwan, 10 June 2016

Oncology

Key words: Histone deacetylase inhibitor, radiation, triple-negative breast cancer, autophagy [more]

Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation

Tobias Bergler, Bettina Jung, Felix Bourier, Louisa Kühne, Miriam C. Banas, Petra Rümmele, Simone Wurm, Bernhard Banas

PLoS One (PLOS) Germany, 10 June 2016

Transplantation Medicine

Key words: Macropaghes, T-lymphocytes, calcineriurin, inhibitor, renal transplantation [more]

Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer’s Disease

Cheng-Chun Wu, Cheng-Chang Lien, Wen-Hsien Hou, Po-Min Chiang ,Kuen-Jer Tsai

Scientific Reports (Nature) Taiwan, 06 June 2016

Neuroscience

Key words: Dementia, neural stem cells, regeneration and repair in the nervous system, stem-cell research [more]

Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai, CY Huang, MY Hua, CK Yeh, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 26 May 2016

Neuroscience

Key words: Focused ultrasound, Gene therapy, Blood-brain barrier opening, Microbubbles, GDNF [more]

Functional studies on primary tubular epithelial cells indicate a tumor suppressor role of SETD2 in clear cell renal cell carcinoma

J Li, J Kluiver, J Osinga, H Westers, MB van Werkhoven, Marc A Seelen, Rolf H Sijmons, Ankevan den Berg, Klaas Kok

Neoplasia (Elsevier) The Netherlands, 26 May 2016

Oncology

Key words: Primary Tubular Epithelial Cells, Tumor Suppression, SETD2, Renal Cell Carcinoma [more]

GBIQ: a non-arbitrary, non-biased method for quantification of fluorescent images

Youichirou Ninomiya, Wei Zhao,Yumiko Saga

Scientific Reports (Nature) Japan, 23 May 2016

Medical Image Analysis

Key words: Image processing, software [more]

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

Daniela F. Quail, Robert L. Bowman, Leila Akkari, Marsha L. Quick, Alberto J. Schuhmacher, Jason T. Huse, Eric C. Holland, James C. Sutton, Johanna A. Joyce

Science (American Association for the Advancement of Science) USA, 20 May 2016

Oncology

Key words: Mouse models, glioblastoma multiforme, macrophage [more]

Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice

Li-Fang Wang, Kazunari K. Yokoyama, Chih-Lung Lin, Tzu-Yin Chen, Hsiu-Wen Hsiao, Pei-Chi Chiang, Chin Hsu

Scientific Reports (Nature) Taiwan, 20 May 2016

Neuroscience

Key words: Neuronal physiology, reproductive biology [more]