Customer Publications (A total of 2312 papers published)
GPRC5A reduction contributes to pollutant benzo [a] pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients
Science of The Total Environment (Elsevier) China, 03 June 2020
Toxicology
Key words: Pulmonary Fibrosis, GPRC5A, Benzo[A]Pyrene Pollution, Epithelium, Prognosis [more]
Organism: Human
Tissue: Lung
Pathological State: Pneumonia
AB0154 MERTK AND THE RESOLUTION OF INFLAMMATION IN IGG4-RELATED DISEASE
Annals of the Rheumatic Diseases (BMJ Journals) Italy, Japan, USA, 02 June 2020
Immunology
Organism: Human
Tissue: Tonsil
Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer
Journal of Hematology & Oncology (Springer) Taiwan, 01 June 2020
Oncology
Key words: Lung Cancer, Oct4, M2 Macrophage, Tumor-Associated Macrophage, M-CSF [more]
Organism: Human, Mouse
Tissue: Lung
Pathological State: Cancer
CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining
Journal of Biomedical Materials Research: Part B (Wiley) Germany, UK, 30 May 2020
Biological Materials
Key words: Fluorescence Microscopy, Foreign Body Reaction, Lymphocyte, Macrophage, Mesh [more]
Organism: Human
Tissue: Stomach
Pathological State: Abdominal Wall Hernia
CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease
Journal of Allergy and Clinical Immunology (Mosby) USA, Japan, The Netherlands, Canada, China, Italy, 29 May 2020
Immunology
Key words: IgG4-RD, CD4+CTL, CD8+CTL, Apoptosis, CD28lo, CD28(Null) [more]
Organism: Human
Tissue: Salivary Gland
Pathological State: Sjögren's Syndrome
Caveolar communication with xenobiotic-stalled ribosomes compromises gut barrier integrity
Communications Biology (Nature) South Korea, 27 May 2020
Gastroenterology
Key words: Biomarkers, Cell Biology, Chemokines, Inflammation, Signal Transduction [more]
Organism: Mouse
Tissue: Small Intestine
Interaction of different cell types with magnesium modified by plasma electrolytic oxidation
Colloids and Surfaces B: Biointerfaces (Elsevier) Colombia, The Netherlands, 26 May 2020
Biological Materials
Key words: Magnesium, PEO, Adipose-Derived Stromal, ASC, Differentiation, Cytotoxicity [more]
Organism: Human
Cell Line: HUVECs, ACSs
Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way
Mechanisms of Ageing and Development (Elsevier) Germany, 22 May 2020
Osteology
Key words: Bone, Osteoblast, Osteoclast, α -Calcitonin Gene-Related Peptide (α -CGRP), Osteopenia [more]
Organism: Mouse
Tissue: Bone
KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation
International Journal of Molecular Sciences (MDPI) The Netherlands, Hungary, 21 May 2020
Oncology
Key words: Pigenetic Editing, KRAB, Gene Repression, PLOD2, Fibrosis, Cancer [more]
Organism: Human
Cell Line: Human skin fibroblasts
Synergistic effect of cell-derived extracellular matrix and topography on osteogenesis of mesenchymal stem cells
ACS Applied Materials & Interfaces (ACS Publications) The Netherlands, 18 May 2020
Tissue Engineering
Key words: Extracellular Matrix, Topography, Mesenchymal Stem Cells, Osteogenic Differentiation, Mechanotransduction [more]
Organism: Human
Cell Line: hBM-MSCs
Biomimetic Multiscale Hierarchical Topography Enhances Osteogenic Differentiation of Human Mesenchymal Stem Cells
Advanced Materials Interfaces (Wiley) The Netherlands, China, 13 May 2020
Stem Cell Research
Key words: Collagen, Extracellular Matrix, Hierarchical Topography, Human Mesenchymal Stem Cells, Mechanotransduction, Osteogenic Differentiation [more]
Organism: Human
Cell Line: hBM‐MSCs
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome
OncoImmunology (Taylor & Francis) The Netherlands, France, Canada, 13 May 2020
Oncology, Immunology
Key words: Epithelial Ovarian Cancer, Chemotherapy, Tumor Microenvironment, Cancer Immunology, MHC-I [more]
Organism: Human
Tissue: Ovaries, Lymphoid Tissue
Pathological State: Cancer
Progesteron receptor expression in insulin producing cells of neuroendocrine neoplasms
The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Japan, Germany, 11 May 2020
Endocrinology
Key words: Neuroendocrine Neoplasm, Insulinoma, Progesteron Receptor [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program
Infectious Agents and Cancer (BMC) Italy, Germany, UK, Kenya, Egypt,, 06 May 2020
Oncology, Virology
Key words: Burkitt Lymphoma, Tumour Microenvironment, EBV, PD-L1, Immunotherapy, Immune Checkpoint [more]
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: Cancer
Decoupling the Amplitude and Wavelength of Anisotropic Topography and the Influence on Osteogenic Differentiation of Mesenchymal Stem Cells Using a High-Throughput Screening Approach
ACS Applied Bio Materials (ACS Publications) The Netherlands, China, 06 May 2020
Stem Cell Research
Organism: Human
Cell Line: hBM-MSCs
High‐Throughput Screening and Hierarchical Topography‐Mediated Neural Differentiation of Mesenchymal Stem Cells
Advanced Healthcare Materials (Wiley Online Library) The Netherlands, 04 May 2020
Stem Cell Research
Key words: Anisotropic Topography, Hierarchical Structures, High‐Throughput Screening, Human Mesenchymal Stem Cells, Neural Differentiation [more]
Organism: Human
Cell Line: hMSCs
The Prognostic and Predictive Value of SOX2+ Cell Densities in Patients Treated for Colorectal Cancer
Cancers (MDPI) Australia, 29 April 2020
Oncology
Key words: SOX2, Colorectal Cancer, Chemotherapy, Prognosis, Oxaliplatin, 5-Fluorouracil, Cancer Stem Cell [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research
Molecular Psychiatry (Nature) Japan, Brazil, USA, Poland, 29 April 2020
Cell Biology, Neuroscience
Key words: Cell Biology, Diseases, Molecular Biology, Neuroscience [more]
Organism: Mouse
Cell Line: E14Tg2A cells
Acute Effects of Pulmonary Exposure to Zinc Oxide Nanoparticles on Brain in Vivo 2
Aerosol and Air Quality Research (AAQR) Taiwan, 25 April 2020
Nanomedicine
Key words: Autophagy, Central Nervous System, Elevated Plus Maze, Morris Water Maze, Nanoparticle, Ubiquitin. [more]
Organism: Rat
Tissue: Brain
A characteristic expression pattern of core circadian genes in the diurnal tree shrew
Neuroscience (Elsevier) China, 25 April 2020
Neuroscience
Key words: Tree Shrew, Diurnal Animal, Circadian Gene, Brain Rhythm, Peripheral Rhythm [more]
Organism: Tree Shrew
Tissue: Brain
In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique
Surface and Coatings Technology (Elsevier) Taiwan, 21 April 2020
Biological Materials
Key words: HiPIMS, TiN, Acrylamide Crosslinking, BMP2 Attachment, In Vitro And In Vivo Studies [more]
Organism: Mouse
Tissue: Skin
Characterization of CD103+ CD8+ tissue‑resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti‑PD‑1 blockade
Cancer Immunology, Immunotherpay (Springer) China, 20 April 2020
Oncology, Immunology
Key words: CD103, Tissue-Resident T Cells, Tumor-Infiltrating Lymphocytes, Esophageal Squamous Cell Carcinoma [more]
Organism: Mouse
Tissue: Skin
Pathological State: Cancer
The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos
International Journal of Molecular Sciences (MDPI) Taiwan, 20 April 2020
Nanomedicine
Key words: Zebrafish Embryos, Acute Toxicity, Silver Nanoparticles, Chorion Pore Size, Lysosomal Activity, Apoptosis [more]
Organism: Zebrafish
Tissue: Whole Organism
Macrophages and Fibroblasts Differentially Contribute to Tattoo Stability
Dermatology (Karger) France, Germany, 19 April 2020
Dermatology
Key words: Tattoo, Macrophage, Fibroblast, Tattoo Maintenance [more]
Organism: Human
Tissue: Skin
Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit
iScience (Cell Press) South Korea, 18 April 2020
Cell Biology
Key words: CTGF/CCN2, Wnt, Ribosomal Insult, Colorectal Cancer, Tumor Niche [more]
Organism: Human
Cell Line: HCT8 and HCT116 cells
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma
OncoImmunology (Taylor & Francis) USA, 16 April 2020
Oncology, Immunology
Key words: Immunotherapy, Bladder Cancer, Macrophage, T Cell, Checkpoint Inhibitor [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Functional diversity between HSP70 paralogs due to variable interactions with specific co-chaperones.
Journal of Biological Chemistry (ASBMB) The Netherlands, Germany, 13 April 2020
Cell Biology
Key words: Hsp110, HSPA4, HSPH2, Protein Folding, Superoxide Dismutase (SOD), 70 Kilodalton Heat Shock Protein (Hsp70), Proteostasis Amyotrophic Lateral Sclerosis (ALS) (Lou Gehrig Disease), Heat Shock Protein (HSP) [more]
Organism: Human
Cell Line: HEK293 Cells
IFN-κ suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis
Science Signaling (AAAS) China, 07 April 2020
Immunology
Organism: Mouse
Tissue: Lung
EMI2 expression as a poor prognostic factor in patients with breast cancer
Kaohsiung Journal of Medical Sciences (Wiley) Taiwan, Japan, 06 April 2020
Oncology
Key words: Breast Cancer, EMI2 (FBXO43), Metastasis
Topography induced stiffness alteration of stem cells influences osteogenic differentiation
Biomaterials Science (Royal Society of Chemistry) The Netherlands, China, 05 April 2020
Stem Cell Research
Organism: Human
Cell Line: hBM-MSCs
Loss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis
Translational Oncology (Elsevier) South Korea, 03 April 2020
Oncology
Organism: Human
Cell Line: Endothelial Cells
Anti-apoptotic molecule BCL2 is a therapeutic target in steroid-refractory graft-versus-host disease
Journal of Investigative Dermatology (Elsevier) Austria, 02 April 2020
Dermatology
Organism: Human
Tissue: Skin
Thyrotropin receptor signaling deficiency impairs spatial learning and memory in mice
Journal of Endocrinology (Society for Endocrinology) China, 01 April 2020
Endocrinology
Distinct galectin profile in inflammation-mediated cartilage damage
Osteoarthritis and Cartilage (OARSI Journal) Austria, 01 April 2020
Osteology
Organism: Mouse
Tissue: Joint Tissue, Bone
Pathological State: Arthritis
Anti-VEGF Treatment Enhances CD8+ T-Cell Antitumor Activity by Amplifying Hypoxia
Cancer Immunology Research (AACR Publications) USA, 27 March 2020
Oncology
Key words: VEGF, CD8+ T Cells, Hypoxia, Angiogenesis, Hypoxia-Inducible Factor-1a [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling
Cancer Science (Japanese Cancer Association) Taiwan, 25 March 2020
Oncology
Key words: CD109, EGFR, Lung Cancer, Metastasis, mTOR [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Functionalized graphene oxide thin films for anti-tumor drug delivery to melanoma cells
Frontiers in Chemistry (Frontiers Media S.A.) Romania, 25 March 2020
Nanomedicine
Organism: Human
Cell Line: HDF cells, NHEM cells
Advancements in developing an effective and preventive dengue vaccine
Future Virology (Future Medicine) Pakistan, 24 March 2020
Virology
Key words: Aedes Mosquito, Chimeric Vaccine, Dengue Fever, Dengue Virus, Endemic, Pandemic, Public Health, Subtropical, Tropical, Vaccines
Soluble Alpha-Klotho Alleviates Cardiac Fibrosis without Altering Cardiomyocytes Renewal
International Journal of Molecular Sciences (MDPI) Taiwan, 22 March 2020
Cardiology
Key words: Klotho, FGF-23, Cardiac Fibrosis, Genetic Fate Mapping [more]
Organism: Mouse
Tissue: Heart
Iron and advanced glycation end products: Emerging role of iron in androgen deficiency in obesity
Antioxidants (MDPI) Taiwan, 22 March 2020
Endocrinology
Key words: Obesity, Iron, Fat, Advanced Glycation End Products, Testis, Testosterone [more]
Organism: Rat
Tissue: Liver, Testis
Pathological State: Obesity
Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors
Cancers (MDPI) Taiwan, Vietnam, 22 March 2020
Oncology
Key words: Myc- ATRTs, Protein Synthesis, Proteasome Degradation, Bortezomib, p53 [more]
Organism: Human, Mouse
Tissue: Brain, Xenograft Tumor
Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion
International Journal of Molecular Sciences (MDPI) Taiwan, 21 March 2020
Neuroscience
Key words: Vascular Cognitive Impairment, Chronic Cerebral Hypoperfusion, Modified Bilateral Common Carotid Artery Occlusion, HMGB1 [more]
Organism: Mouse
Tissue: Brain
Analysis of sensitivity and specificity: precise recognition of neutrophils during regeneration of contused skeletal muscle in rats
Forensic Sciences Research (Taylor & Francis) China, 19 March 2020
Neuroscience
Key words: Forensic Sciences, Forensic Pathology, Immunohistochemistry, TissueFaxs 200 Digital Pathological Analysis System, Parameter Optimization, Cut-Off Value Of Staining Area, Neutrophil Staining Area [more]
Organism: Rat
Tissue: Muscle
Autophagy attenuates high glucose-induced oxidative injury to lens epithelial cells
Bioscience Reports (Portland Press) China, 18 March 2020
Endocrinology
Key words: Diabetic Cataract, High Glucose, Autophagy, Oxidative Stress, Lens [more]
Organism: Mouse
Tissue: Eye
MeCP2 mediates transgenerational transmission of chronic pain
Progress in Neurobiology (Elsevier) China, USA, 18 March 2020
Neuroscience
Key words: Chronic Pain, MeCP2, Primary Somatosensory Cortex, Glutamatergic Neuron, Transgenerational Transmission [more]
Organism: Mouse
Tissue: Brain
Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation
Scientific Reports (Nature) Taiwan, Japan, 18 March 2020
Neuroscience
Key words: Apoptosis, Molecular Neuroscience [more]
Organism: Mouse
Tissue: Brain
Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APC Min/+ mice
Cancer Immunology, Immunotherpay (Springer) Sweden, 17 March 2020
Immunology
Key words: Regulatory T Cells, APCmin/+, Colon Cancer, Tumor-Infiltrating Lymphocytes, Anti-Tumor Immunity [more]
Organism: Mouse
Tissue: Small Intestine
Pathological State: Cancer
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis
Nature Metabolism (Nature) China, 16 March 2020
Oncology
Key words: Cancer, Cancer Metabolism, Cell Growth [more]
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: Cancer
Long-Term Deleterious Effects of Short-term Hyperoxia on Cancer Progression—Is Brain-Derived Neurotrophic Factor an Important Mediator? An Experimental Study
Cancers (MDPI) Romania, 14 March 2020
Oncology
Key words: Cancer Progression, Breast Cancer, Hyperoxia, Perioperative, Metastasis, BDNF, Vimentin, E-Cadherin, Epithelial Mesenchymal Transition, Angiogenesis [more]
Cell Line: human MDA-MB-231 and murine 4T1 TNBC cell lines
Proteomic profiling of hepatic stellate cells in alcohol liver fibrosis reveals proteins involved in collagen production
Alcohol (Elsevier) China, 12 March 2020
Hepathology
Key words: Ethanol, Liver, HSC, Proteomics, Collagen, Ndufv2 [more]
Organism: Rat
Tissue: Liver
Pathological State: Liver Fibrosis
Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction
Cardiovascular Ultrasound (BMC) USA, 12 March 2020
Cardiology
Organism: Mouse
Tissue: Heart
Pathological State: Myocardial Infarction
Placental Morphology and Cellular Characteristics in Stillbirths in Women With Diabetes and Unexplained Stillbirths
Archives of Pathology & Laboratory Medicine (College of American Pathologists) UK, 09 March 2020
Reproductive Medicine
Organism: Human
Tissue: Placenta
Pathological State: Diabetes
PTH hypersecretion triggered by a GABA B1 and Ca 2+-sensing receptor heterocomplex in hyperparathyroidism
Nature Metabolism (Nature) USA, 09 March 2020
Endocrinology
Key words: Calcium and Vitamin D, Homeostasis, Mechanisms Of Disease, Parathyroid Diseases [more]
Organism: Mouse
Tissue: Thyroid
Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement
Scientific Reports (Nature) Taiwan, 09 March 2020
Tissue Engineering
Key words: Biophysics, Medical Research [more]
Organism: Mouse
Tissue: Skin
Surface functionalization of pegylated gold nanoparticles with antioxidants suppresses nanoparticle-induced oxidative stress and neurotoxicity
Chemical Research in Toxicology (ACS Publications) China, 05 March 2020
Toxicology
Key words: Pegylation, Gold Nanoparticle, Neurotoxicity, Drug Delivery [more]
Organism: Mouse
Tissue: Brain
Topography Mediated Fibroblast Cell Migration is Influenced by Direction, Wavelength, and Amplitude
ACS Applied Bio Materials (ACS Publications) , 04 March 2020
Biological Materials
Key words: Topography, Gradient, Cell Migration, Biointerface, Wound Healing [more]
Organism: Human
Cell Line: Fibroblasts
Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR-AKT-mTOR signaling
Cancer Science (Wiley) Taiwan, 04 March 2020
Oncology
Key words: CD109, EGFR, Lung Cancer, Metastasis, mTOR [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure
Science Translational Medicine (AAAS) USA, 04 March 2020
Endocrinology
Organism: Human
Tissue: Joint Tissue
Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma
Immunity, Inflammation and Disease (Wiley) Germany, 03 March 2020
Immunology, Oncology
Key words: Alveolar Macrophages, Clodronate Liposomes, EGFR Mutation, Interstitial Macrophages, Lung Cancer [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Artificial intelligence as the next step towards precision pathology
Journal of Internal Medicine (Wiley) Sweden, 03 March 2020
Medical Imaging
Key words: Artificial Intelligence, Deep Learning, Digital Image Analysis, Digital Pathology, Machine Learning, Pathology
Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes
The FASEB Journal (FASEB) Taiwan, 03 March 2020
Osteology
Key words: Chondrocytes, DDR1, Discoidin Domain Receptor 1, Endochondral Ossification, Skeletal Development [more]
Organism: Mouse
Tissue: Bone
Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas
Clinical Cancer Research (AACR Publications) Germany, 02 March 2020
Oncology
Key words: Clinically Aggressive Meningioma, T-Cell Infiltration, Primary and Recurrent Tumors TILs, PD-1 [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats
Experimental Neurology (Elsevier) Taiwan, USA, 29 February 2020
Neuroscience
Key words: Status Epilepticus, Seizure, Electroencephalography, Mossy Fiber Sproutin, gBrain -Derived Neurotrophic Factor, Transcranial Direct Current Stimulation [more]
Organism: Rat
Tissue: Brain
Pathological State: Seizures
The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray
Cancers (MDPI) Austria, 29 February 2020
Oncology
Key words: Irradiated Rectal Cancer, Immunoscore, Virtual Microscopy, Digital Pathology, Tissue Microarray (TMA) [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Dermal fillers do not induce upregulation of NLRP3 inflammasomes or expression of inflammatory cytokines in granulomas
Journal of Cosmetic Dermatology (Wiley) Germany, Japan, 28 February 2020
Dermatology
Key words: Caspase, Fillers, Granulomas, Inflammasome, Interleukins [more]
Organism: Human
Tissue: Skin
A transcriptionally distinct CXCL13+ CD103+ CD8+ T-cell population is associated with B-cell recruitment and neoantigen load in human cancer
Cancer Immunology Research (AACR Publications) The Netherlands, UK, Canada, 27 February 2020
Oncology
Key words: CXCL13, TGFβ1, Tertiary Lymphoid Structures, CD103+ T Cell, Immune Checkpoint Inhibitors [more]
Organism: Human
Pathological State: Cancer
Ultrasound-responsive neurotrophic factor-loaded microbubble-liposome complex: Preclinical investigation for Parkinson's disease treatment
Journal of Controlled Release (Elsevier) Taiwan, 27 February 2020
Neuroscience
Key words: Ultrasound (US)-Targeted Microbubble Destruction (UTMD), Gene Therapy, Blood-Brain Barrier Opening, GDNF, BDNF [more]
Organism: Mouse
Tissue: Brain
Pathological State: Parkinson's Disease
cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer
Stem Cells (Wiley) China, 26 February 2020
Oncology
Key words: Cancer Stem Cells, CD133, CD24, CD44, cPLA2α, Epithelial‐Mesenchymal Transition [more]
Organism: Human
Tissue: Uterus
Pathological State: Cancer
Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway
Journal of Cachexia, Sarcopenia and Muscle (Wiley) South Korea, 25 February 2020
Neuroscience
Key words: Exercise Mimetic, Hypertrophic Response, Indoprofen, Muscle Wasting, Muscle Weakness, PDK1 [more]
Organism: Mouse
Tissue: Muscle
Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations
Neuron (Cell Press) China, 25 February 2020
Neuroscience
Key words: Corticotropin-Releasing Factor Neurons, Prefrontal Cortex, Behavioral Style Selection, Social Defeat Stress [more]
Organism: Mouse
Tissue: Brain
Sox2 induces tumorigenesis and angiogenesis of early-stage esophageal squamous cell carcinoma through secretion of Suprabasin
Carcinogenesis (Oxford University Press) Japan, 14 February 2020
Oncology
Key words: Sox2, Esophageal Cancer, Suprabasin, Carcinogenesis, Angiogenesis [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental Study on Porcine Models
CardioVascular and Interventional Radiology (Springer) Czech Republic, Israel, 13 February 2020
Cardiology
Key words: Liposomal Doxorubicin, Radiofrequency Ablation, Irreversible Electroporation [more]
Organism: Pig
Tissue: Liver
The Impact of Cand1 in Prostate Cancer
Cancers (MDPI) Austria, Germany, 12 February 2020
Oncology
Key words: Prostate Cancer, Cand1, Cancer Aggressiveness, Survival, Tumor Recurrence, Mutation, Enzalutamide Resistance [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance
Cells (MDPI) Austria, Hungary, 12 February 2020
Oncology
Key words: Silibinin, MRX34, PD-L1, NRF2, Krüppel-Like Factors (KLFs), Neurotrophin [more]
Organism: Human
Tissue: Mucosa
Pathological State: Cancer
MRI radiomics for early prediction of response to vaccine therapy in a transgenic mouse model of pancreatic ductal adenocarcinoma
Journal of Translational Medicine (BMC) USA, China, 10 February 2020
Gastroenterology
Key words: Dendritic Cell Vaccine, Machine Learning, Magnetic Resonance Imaging, Pancreatic Ductal Adenocarcinoma, Radiomics [more]
Organism: Mouse
Tissue: Xenograft Tumor, Pancreas
Pathological State: Cancer
Single cell approaches to address adipose tissue stromal cell heterogeneity
Biochemical Journal (Portland Press) USA, 06 February 2020
Endocrinology
Key words: Plasticity, Single Cell RNA-Seq, Stromal Cells, White Adipose Tissue
Acquisition of chromosome instability is a mechanism to evade oncogene addiction
EMBO Molecular Medicine (EMBO press) Germany, 06 February 2020
Oncology
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability
Oncogenesis (Nature) Taiwan, 04 February 2020
Oncology
Key words: CNS Cancer, Growth Factor Signalling [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy
Aging (Impact Journals) China, 31 January 2020
Cardiology
Key words: Atherosclerosis, Macrophage Polarization, Autophagy, Sirt1, Araloside C [more]
Organism: Mouse
Tissue: Heart
Pathological State: Atherosclerosis
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I
Cancers (MDPI) Italy, 30 January 2020
Oncology
Key words: Glioblastoma Multiforme (GB), Ubiquitylation, E3-Ligase, MEX3A, RIG-I [more]
Organism: Human
Pathological State: Cancer
Cell Line: glioblastoma A-172 cells
Unidirectional rotating molecular motors dynamically interact with adsorbed proteins to direct the fate of mesenchymal stem cells
Science Advances (AAAS) China, The Netherlands, 29 January 2020
Biological Materials
Organism: Human
Cell Line: hBM-MSCs Cells
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas
Molecular Cancer (BMC) China, USA, 28 January 2020
Oncology
Key words: Circ-MAPK4, P38/MAPK Signaling Pathway, MiR-125a-3p, Gliomas, Apoptosis [more]
Organism: Mouse
Tissue: Xenograft Tumor, Brain
Pathological State: Cancer
Cytotoxic CD4+ T lymphocytes may induce epithelial cell apoptosis in systemic sclerosis
The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, Japan, The Netherlands, Canada, China, 28 January 2020
Immunology
Organism: Human
Tissue: Skin
The Establishment of Esophageal Precancerous Lesion Model by Using p53 Conditional Knockout Mouse in Esophageal Epithelium
BioMed Research International (Hindawi Publishing Corporation) China, 25 January 2020
Oncology
Organism: Mouse
Tissue: Esophagus
Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice
Biomaterials (Elsevier) China, 25 January 2020
Biological Materials
Key words: Exosome, Duchenne Muscular Dystrophy, Myostatin, Propeptide [more]
Organism: Rat
Tissue: Muscle, Liver, Kidney
Surfactant expression defines an inflamed subtype of lung adenocarcinoma brain metastases that correlates with prolonged survival
Clinical Cancer Research (AACR Publications) Germany, 17 January 2020
Oncology
Organism: Human
Tissue: Lung
Pathological State: Cancer
Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation
BMC Complementary Medicine and Therapies (BMC) South Korea, 13 January 2020
Oncology
Key words: Apoptosis, TNF-α, TNFR1, NF-κB, C. Militaris [more]
Organism: Human
Cell Line: SKOV-3 Cells
High Extra-tumoral Mast Cell Counts are Associated with a Higher Risk of Adverse Prostate Cancer Outcomes
Cancer Epidemiology, Biomarkers & Prevention (AACR Publications) USA, 13 January 2020
Oncology
Novel titanium-apatite hybrid scaffolds with spongy bone-like micro architecture intended for spinal application: In vitro and in vivo study
Materials Science and Engineering: C (Elsevier) Romania, Spain, 11 January 2020
Biological Materials
Key words: Titanium-Apatite Hybrid Scaffolds, Osteogenic Biomimetic Porous Scaffolds, Hydroxyapatite Bioactive Matrix, Bone Restoration, Spinal Fusion, Additive Manufacturing [more]
Organism: Human
Cell Line: Osteoblasts
Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer
International Journal of Molecular Sciences (MDPI) Taiwan, 08 January 2020
Oncology, Microbiology
Key words: FOLFOX, Fecal Microbiota Transplant, Intestinal Mucositis, Apoptosis, Gut Microbiota [more]
Organism: Mouse
Tissue: Small Intestine
Pathological State: Cancer
Impact of the Sensory and Sympathetic Nervous System on Fracture Healing in Ovariectomized Mice
International Journal of Molecular Sciences (MDPI) Germany, 08 January 2020
Neuroscience
Key words: Fracture, Substance P, Alpha-CGRP, Sympathectomy, Sympathetic Nerve Fibers, Ovariectomy, Sensory Nervous System, Bone Repair, Bone Remodeling [more]
Organism: Mouse
Tissue: Bone
Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model
Bone (Elsevier) Germany, 08 January 2020
Osteology
Key words: Osteoarthritis, Destabilization of The Medial Meniscus, Substance P, Alpha- Calcitonin Gene-Related Peptide, Bone, Cartilage [more]
Organism: Mouse
Tissue: Bone
Racial difference in prostate cancer cell telomere lengths in men with higher-grade prostate cancer: a clue to the racial disparity in prostate cancer outcomes
Cancer Epidemiology, Biomarkers & Prevention (AACR Publications) USA, 08 January 2020
Oncology
Efficient Labeling Of Mesenchymal Stem Cells For High Sensitivity Long-Term MRI Monitoring In Live Mice Brains
International Journal of Nanomedicine (Dove Press) Taiwan, 08 January 2020
Nanomedicine
Key words: Iron Oxide Nanoparticles, FGF21, Regenerative Medicine, Tracking of Cells, Non-Invasive Imaging Modality [more]
Organism: Human
Cell Line: Mesenchymal Stem Cells
Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway
Drug Design, Development and Therapy (Dove Press) China, 07 January 2020
Neuroscience
Key words: Cerebral Ischemia/Reperfusion Injury, Chlorogenic Acid, Oxidative Stress, Neuroprotection, NF-E2-Related Factor 2 Pathway [more]
Organism: Rat
Tissue: Brain
Pathological State: Cerebral Ischemia
The MyoD family inhibitor domain-containing protein enhances the chemoresistance of cancer stem cells in the epithelial state by increasing β-catenin activity
Oncogene (Nature) Taiwan, 07 January 2020
Oncology
Key words: Non-Small Lung Cancer, Prognostic [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior
The FASEB Journal (Wiley) Taiwan, 07 January 2020
Neuroscience
Key words: Guanine Nucleotide Exchange Factor (GEF), Hyperlocomotion, Neuroplasticity, Serotonergic Fiber, Serotonin (5‐HT), TIAM2 [more]
Organism: Mouse
Tissue: Brain
Microvascular Disease in Chronic Thromboembolic Pulmonary Hypertension: Hemodynamic Phenotyping and Histomorphometric Assessment
Circulation (American Heart Association) Austria, Germany, France, Hungary, 03 January 2020
Cardiology
Key words: Chronic Thromboembolic Pulmonary Hypertension, Upstream Resistance, Pulmonary Vascular Resistance, Pulmonary Arterial Compliance, Microvascular Disease [more]
Organism: Human
Tissue: Lung
Anti-BAFF treatment interferes with humoral responses in a model of renal transplantation in rats
Transplantation (Wolters Kluwer) Germany, 01 January 2020
Transplantation Medicine
Organism: Rat
Tissue: Kidney
Effects of neoadjuvant FOLFIRONOX and gemcitabine-based chemotherapy on cancer cell survival and death in patients with pancreatic ductal adenocarcinoma
Oncotarget (Impact Journals) Germany, 31 December 2019
Oncology
Key words: autophagy, cell death, stroma, neoadjuvant therapy, prognosis [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo
Cancers (MDPI) Taiwan, 30 December 2019
Oncology
Key words: Magnolol, Sorafenib, AKT, Hepatocellular carcinoma [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra
International Journal of Molecular Sciences (MDPI) Taiwan, 27 December 2019
Neuroscience
Key words: high-fat diet (HFD), dopamine (DA), Parkinson disease (PD), peroxisome proliferator-activated receptor (PPAR) [more]
Organism: Mouse
Tissue: Brain
Nanoplatforms with Remarkably Enhanced Absorption in the Second Biological Window for Effective Tumor Thermo-Radiotherapy
ACS Applied Materials & Interfaces (ACS Publications) China, 25 December 2019
Nanomedicine
Key words: Copper sulfide, Gold, Second near-infrared window, Thermo-radiotherapy, Synergistic effect [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Dendritic cells treated with a prostaglandin I2 analog, iloprost, promote antigen-specific regulatory T cell differentiation in mice
International Immunopharmacology (Elsevier) Taiwan, 23 December 2019
Immunology
Key words: Allergic inflammation, Prostaglandin I2, mPEG-PLGA hydrogel, Regulatory T-cell, Tolerogenic dendritic cell, PD-L1 [more]
Organism: Mouse
Tissue: Lung
Heat-killed Mycobacterium paragordonae therapy exerts an anti-cancer immune response via enhanced immune cell mediated oncolytic activity in xenograft mice model
Cancer Letters (Elsevier) South Korea, 23 December 2019
Oncology
Key words: Cancer immnotherapy, Natural killer cells, Dendritic cells, Interleukin-12 [more]
Organism: Mouse
Tissue: Colon
Pathological State: Cancer
Switching to a Healthy Diet Prevents the Detrimental Effects of Western Diet in a Colitis-Associated Colorectal Cancer Model
Nutrients (MDPI) Austria, Germany, 23 December 2019
Oncology, Gastroenterology
Key words: inflammatory bowel disease, colitis-associated cancer, microbiome, western diet, vitamin D, non-alcoholic fatty liver disease, CYP24A1, Wnt pathway, aberrant crypt foci, mucosal regeneration [more]
Organism: Mouse
Tissue: Colon
Pathological State: Cancer
Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer
Cancers (MDPI) Taiwan, 20 December 2019
Oncology
Key words: Breast cancer, Visfatin, Adipose-derived stem cells (ADSCs), GDF15 [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Modulating Macrophage Phenotype by Sustained MicroRNA Delivery Improves Host‐Implant Integration
Advanced Healthcare Materials (Wiley) Singapore, USA, The Netherlands, 18 December 2019
Tissue Engineering
Key words: Electrospinning, Fibrous capsule formation, Gene silencing, RNA interference, Tissue engineering [more]
Organism: Mouse
Rhubarb-evoke Mucus Secretion through Aggregation and Degranulation of Mast cell in the colon of Rat: in vivo and ex vivo studies
Scientific Reports (Nature) China, 18 December 2019
Gastroenterology
Key words: Gastroenterology, Physiology
Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence
Experimental Cell Research (Elsevier) Germany, 16 December 2019
Tissue Engineering
Key words: TGF, Vascular smooth muscle cells, Differentiation, 3D culture [more]
Organism: Human
Cell Line: HUASMCs
Effects of Circadian Rhythm Disorder on the Hippocampus of SHR and WKY Rats
Neurobiology of Learning and Memory (Elsevier) China, 16 December 2019
Neuroscience
Key words: Circadian rhythm disorder, Hypertension, Cognition, Hippocampus [more]
Organism: Rat
Tissue: Brain
Pathological State: Circadian Rhythm Disorder
Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice
Nutrients (MDPI) Austria, Germany, UK, 16 December 2019
Gastroenterology
Key words: IBD, Colitis, Inflammation, Calcium, Mucin [more]
Organism: Mouse
Tissue: Colon
Pathological State: Colitis
Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations
Clinical Cancer Research (AACR Publications) USA, Mexico, France, 12 December 2019
Oncology
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice
Blood Advances (ASH Publications) USA, 10 December 2019
Cardiology
Organism: Mouse
Tissue: Heart
Targeting FOXA1-mediated repression of TGF-b signaling suppresses castration-resistant prostate cancer progression
JCI Insight (American Society of Clinical Investigation) USA, 04 December 2019
Oncology
Key words: Genetics, Oncology, Prostate Cancer [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
Molecular Pattern and Density of Axons in the Long Head of the Biceps Tendon and the Superior Labrum
Journal of Clinical Medicine (MDPI) Austria, 03 December 2019
Physiology
Key words: axons, pain, long head of the biceps tendon, superior labrum, SLAP [more]
Organism: Human
Tissue: Connective Tissue
Early appearance of key transcription factors influence the spatiotemporal development of the human inner ear
Cell and Tissue Research (Springer) Austria, Canada, Sweden, 02 December 2019
Developmental Biology
Key words: Inner ear, Human, Transcription factors, Immunohistochemistry, SOX2, TAK1, GATA3, Electron microscopy [more]
Organism: Human
Tissue: Bone
PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes
Cell Death & Disease (Nature) South Korea, 02 December 2019
Cardiology
Key words: Cell death, Heart failure [more]
Organism: Mouse
Tissue: Heart
Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease: A case report
Medicine (Wolters Kluwer) Japan, USA, 01 December 2019
Immunology
Key words: CD4+ T cell, CD4+ GATA3+ T cell, IgE, Kimura disease, mast cell [more]
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: Kimura Disease
Histologic Analysis of Sensory and Motor Axons in Branches of the Human Brachial Plexus
Plastic and Reconstructive Surgery (American Society of Plastic Surgeons) USA, 01 December 2019
Regenerative Medicine
Organism: Human
Tissue: Nerves
Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI
Journal of The American Society of Nephrology (American Society of Nephrology) USA, 29 November 2019
Nephrology
Organism: Mouse
Tissue: Kidney
Pathological State: Acute Kidney Injury
Development of Kaempferol-Loaded Gelatin Nanoparticles for the Treatment of Corneal Neovascularization in Mice
Pharmaceutics (MDPI) Taiwan, Australia, 28 November 2019
Nanomedicine
Key words: gelatin nanoparticles, kaempferol, corneal neovascularization, anti-angiogenesis, human umbilical vascular endothelial cells (HUVECs) [more]
Organism: Mouse
Tissue: Eye
DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation
Journal of Experimental & Clinical Cancer Research (BMC) Taiwan, 26 November 2019
Oncology
Key words: , Interleukin-6, Phospho-STAT3, OCT4, DNMT3b, Drug resistance, Hepatocellular carcinoma [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function
Immunity (Elsevier) Austria, USA, Switzerland, Germany, China, 26 November 2019
Immunology
Key words: CD8 T cells, hepatitis, hepatocyte, immunometabolism, infection, inflammation, interferons, liver, urea cycle, virus [more]
Organism: Mouse
Tissue: Liver
Pathological State: LCMV Infection
Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice
mBio (American Society for Microbiology) USA, 26 November 2019
Microbiology
Key words: Mycobacterium tuberculosis, adaptive immunity, Collaborative Cross mice, host genetics, host response, host-pathogen interactions [more]
Organism: Mouse
Tissue: Lung
Pathological State: Tuberculosis
Promising Therapeutic Efficacy of GC1118, an Anti-EGFR Antibody, against KRAS Mutation-Driven Colorectal Cancer Patient-Derived Xenografts
International Journal of Molecular Sciences (MDPI) South Korea, 24 November 2019
Oncology
Key words: colorectal cancer, patient-derived xenograft, EGFR-targeting therapeutic antibody, KRAS mutation, PI3K/mTOR/AKT inhibitor [more]
Organism: Mouse
Tissue: Colon, Xenograft Tumor
Pathological State: Cancer
Translational interest of immune profiling
Precision Medicine for Investigators, Practitioners and Providers (Elsevier) Saudi Arabia, 22 November 2019
Immunology
Key words: Biomarkers, Immunoprofiling, Multiplex Immunohistochemistry, Novel Therapies, Next Generation Sequencing, Protein Arrays, Translational Research, xMAP Assays
Influence of Platelet Lysate on 2D and 3D Amniotic Mesenchymal Stem Cell Cultures
Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) Austria, 15 November 2019
Regenerative Medicine
Key words: mesenchymal stem cells, stress fibers, mitochondrial dynamics, platelet lysate, membrane elasticity [more]
Organism: Human
Cell Line: hMSCs
Cordycepin inhibits human ovarian cancer by inducing autophagy and apoptosis through Dickkopf-related protein 1/β-catenin signaling
American Journal of Translational Regulation (NCBI) South Korea, 15 November 2019
Oncology
Key words: Apoptosis, Dickkopf-related protein 1, β-catenin, autophagy, cordycepin [more]
Organism: Human
Pathological State: Cancer
Cell Line: SKOV-3, OVCAR-3
Endoplasmic reticulum stress-mediated basolateral amygdala GABAergic neuron injury is associated with stress-induced mental disorders in rats
Frontiers in Cellular Neuroscience (NCBI) China, Usa, Mexico, 14 November 2019
Neuroscience
Key words: stress, amygdala, GABAergic neurons, mental disorder, endoplasmic reticulum stress [more]
Organism: Rat
Tissue: Brain
Large‐scale Production of LGR5‐positive Bipotential Human Liver Stem Cells
Hepatology (AASLD) The Netherlands, Spain, Belgium, 12 November 2019
Hepathology
Key words: Liver organoids, suspension culture, spinner flask, hepatocyte differentation, tissue engineering [more]
Organism: Human
Tissue: Liver
Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection
The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, Japan, 12 November 2019
Immunology
Organism: Mouse
Tissue: Lung
Pathological State: Influenza Infection
P2Y6 and P2X7 receptor antagonism exerts neuroprotective/neuroregenerative effects in an animal model of Parkinson's disease
Frontiers in Cellular Neuroscience (Frontiers Media S.A.) Brazil, 08 November 2019
Neuroscience
Key words: purinergic receptors, Brilliant Blue G, P2X7 receptor, MRS2578, P2Y6 receptor, Parkinson’s disease, microglia [more]
Organism: Rat
Tissue: Brain
Pathological State: Parkinson's Disease
A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer
Journal of Materials Chemistry B (Royal Society of Chemistry) China, 08 November 2019
Nanomedicine, Oncology
Organism: Human
Pathological State: Cancer
Cell Line: MDA-MB-231 cells, MCF-7 cells and HeLa cells
Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival
Pharmaceutical Biology (Taylor & Francis) China, 07 November 2019
Gastroenterology
Key words: Periplaneta americana L., gastric diseases, IGF-1/PTEN/Akt signalling, KFX [more]
Organism: Rat
Tissue: Stomach
Pathological State: Gastric Ulcer
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis
Bone research (Nature) USA, 05 November 2019
Osteology
Key words: Bone, Bone quality and biomechanics, Pathogenesis [more]
Organism: Human
Tissue: Bone
Well Plate Integrated Topography Gradient Screening Technology for Studying Cell‐Surface Topography Interactions
Advanced Biosystems (Wiley) The Netherlands, China, 04 November 2019
Biological Materials
Key words: Biointerfaces, gradients, high-throughput screening, stem cells surface topography [more]
Organism: Human
Cell Line: hBM-MSCs
Mapping of c-Fos expression in male tree shrew forebrain
Neuroscience letters (Elsevier) China, 03 November 2019
Neuroscience
Key words: Aversive stimulus, Prefrontal cortex, Lateral septal nucleus, Bed nucleus of the stria terminalis, Hypothalamus, Amygdala [more]
Organism: Tree Shrew
Tissue: Brain
Dendritic cell immunotherapy induces anti-tumor effect in a transgenic mouse model of pancreatic ductal adenocarcinoma
American Journal of Cancer Research (NCBI) USA, China, 01 November 2019
Oncology
Key words: Pancreatic ductal adenocarcinoma, DC-based immunotherapy, magnetic resonance imaging [more]
Organism: Mouse
Tissue: Spleen
Pathological State: Cancer
Phospholipase D2 in prostate cancer: protein expression changes with Gleason score
British Journal of Cancer (Nature) UK, Canada, 01 November 2019
Oncology
Key words: Cell growth, Prostate cancer, Time-lapse imaging [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer
Cancers (MDPI) Taiwan, 01 November 2019
Oncology
Key words: histone deacetylase inhibitor, aggresome, radiation, autophagy, triple-negative breast cancer [more]
Organism: Mouse
Tissue: Breast
Pathological State: Cancer
Directional topography gradients drive optimum alignment and differentiation of human myoblasts
Journal of Tissue Engineering and Regenerative Medicine (Wiley) The Netherlands, 01 November 2019
Regenerative Medicine
Key words: Myoblasts, Myotubes, Polydimethylsiloxane (PDMS), Tissue Engineering, Topography Gradient [more]
Organism: Human
Cell Line: Myoblasts
Responsive exosome nano‐bioconjugates for synergistic cancer therapy
Angewandte Chemie (Wiley) China, Singapore, 31 October 2019
Nanomedicine
Key words: Exosome, immunotherapy, antibodies, cancer, nanoconjugate [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior
CELL (Cell Press) China, 31 October 2019
Neuroscience
Key words: T cell, stress, leukotriene B4, anxiety, purine metabolism, amygdala, AdorA1, IRF-1, xanthine [more]
Organism: Mouse
Cell Line: CD4 T Cells
Distribution of Tyrosine‐Hydroxylase‐Immunoreactive Neurons in the Hypothalamus of Tree Shrews
Journal of Comparative Neurology (Wily) China, 31 October 2019
Neuroscience
Key words: Tyrosine hydroxylase, Hypothalamus, Immunohistochemistry, RRID: AB_2201526, Vasopressin, Aromatic L-amino acid decarboxylase [more]
Organism: Tree Shrew
Tissue: Brain
Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model
Scientific Reports (Nature) Taiwan, 23 October 2019
Endocrinology
Key words: Experimental models of disease, Immunology [more]
Organism: Mouse
Tissue: Heart, Kidney
Pathological State: Diabetes
Nasal Pneumococcal Density is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens
American Journal of Respiratory and Critical Care Medicine (ATS Journals) UK, Brazil, Germany, Malawi, The Netherlands, 18 October 2019
Immunology
Key words: Nasopharygeal colonization, Microaspiration, Alveolar macrophages, Controlled Human Infection model, CD4+ T cells [more]
Organism: Human
Cell Line: BAL Cells
Human Mesenchymal Stem Cell Response to Lactoferrin-based Composite Coatings
Materials (MDPI) Romania, UK, 18 October 2019
Biological Materials
Key words: mesenchymal stem cells, osteogenic differentiation, lactoferrin, polymer composite [more]
Organism: Human
Cell Line: hMSCs
Facile and efficient encapsulation of antimicrobial peptides via crosslinked DNA nanostructures and their application in wound therapy
Journal of Controlled Release (Elsevier) Singapore, 16 October 2019
Nanomedicine
Key words: DNA hydrogel, S. aureus infection, Wound healing, Antimicrobial peptides, Controlled release, Electrostatic interactions [more]
Organism: Mouse
Tissue: Skin
Pathological State: Staphylococcus aureus Infection
Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells
Molecular Cancer Research (AACR Publications) USA, 14 October 2019
Oncology
Key words: ATRX, TERC, Telomeres, Alternative lengthening of telomeres, Cancer, Prostate cancer, telomerase, gene knockout, CRISPR/Cas [more]
Organism: Human
Pathological State: Cancer
Cell Line: LAPC-4 Cells
Comparing the Osteogenic Potentials and Bone Regeneration Capacities of Bone Marrow and Dental Pulp Mesenchymal Stem Cells in a Rabbit Calvarial Bone Defect Model
International Journal of Molecular Sciences (MDPI) Taiwan, 10 October 2019
Regenerative Medicine
Key words: mesenchymal stem cells, dental pulp stem cells, bone marrow stem cells, bone regeneration, calvarial defect [more]
Organism: Rabbit
Tissue: Bone
Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis
Antioxidants (MDPI) Taiwan, 09 October 2019
Biological Materials
Key words: honokiol, cisplatin, kidney injury, oxidative stress, apoptosis, nanotechnology [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Acute Kidney Injury
Loss of smooth muscle CYB5R3 amplifies angiotensin II–induced hypertension by increasing sGC heme oxidation
JCI Insight (American Society of Clinical Investigation) Germany, USA, 03 October 2019
Cardiology
Key words: Vascular Biology, Guanylate cyclase, Hypertension, Nitric oxide [more]
Organism: Mouse
Tissue: Heart, Blood Vessels
Pathological State: Hypertension
Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β1-42 Oligomers
Frontiers in Pharmacology (Frontiers Media S.A.) China, 24 September 2019
Pharmacology
Organism: Mouse
Tissue: Brain
Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8
Theranostics (NCBI) Taiwan, 23 September 2019
Oncology
Key words: pancreatic cancer, PSC, stiffness, organotypic coculture, PAI-1 [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
A Method for Predicting the Success of Pulsinell's Four-Vessel Occlusion Rat Model by LDF Monitoring of Cerebral Blood Flow Decline
Journal of Neuroscience Methods (Elsevier) China, 20 September 2019
Neuroscience
Key words: Global cerebral ischemia-reperfusion injury, Laser Doppler flowmetry, Pulsinelli's four-vessel occlusion method, cerebral blood flow decline [more]
Organism: Rat
Tissue: Brain
Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats
International Journal of Molecular Sciences (MDPI) Taiwan, 18 September 2019
Cardiology
Key words: Right heart failure, oxidation, mitochondria, inflammation, inflammasomes, apoptosis [more]
Organism: Rat
Tissue: Lung
Pathological State: Heart Failure, Hypertension
Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model
Journal of Vascular and Interventional Radiology (Elsevier) China, 18 September 2019
Oncology
Organism: Rabbit
Tissue: Liver
Pathological State: Cancer
Disruption of mitochondrial homeostasis with artemisinin unravels anti-angiogenesis effects via auto-paracrine mechanisms
Theranostics (NCBI) Taiwan, USA, 17 September 2019
Endocrinology
Key words: artemisinin, mitochondria, VEGF, angiogenesis, auto-paracrine [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation
Brain, Behavior, and Immunity (Elsevier) Belgium, Germany, Spain, The Netherlands, 13 September 2019
Immunology, Neuroscience
Key words: iPSC, Microglia, Macrophages, Stroke, Neuroinflammation, Interleukin (IL) 13, Polarisation, Classical activation, Alternative activation [more]
Organism: Mouse
Tissue: Brain
The Effect of Wharton Jelly-Derived Mesenchymal Stromal Cells and Their Conditioned Media in the Treatment of a Rat Spinal Cord Injury
International Journal of Molecular Sciences (MDPI) Czech Republic, 12 September 2019
Neuroscience
Key words: spinal cord injury, mesenchymal stem cells, Wharton’s jelly, conditioned medium, cell secretome, cell therapy [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Next-generation computational tools for interrogating cancer immunity
Nature Reviews Genetics (Nature) Austria, 12 September 2019
Oncology
Key words: Antigen presentation, Cancer genetics, Cancer genomics, Cancer immunotherapy, Computational biology and bioinformatics, Tumor immunology
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
Nature Communications (Nature) China, 11 September 2019
Immunology
Key words: Bacterial Infection, Innate immune cells, Pattern recognition receptors, Ubiquitylation [more]
Organism: Mouse
Tissue: Lung
Region-specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation
JCI Insight (American Society of Clinical Investigation) USA, 10 September 2019
Neuroscience
Organism: Dog
Tissue: Heart
Region specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation
The Journal of Clinical Investigation (Am Soc Clin Investig) USA, 10 September 2019
Cardiology
Organism: Mouse
Tissue: Heart
Calcium‐sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice
Journal of Bone and Mineral Research (Wiley) USA, 09 September 2019
Osteology
Key words: chondrogenesis, osteogenesis, endochondral bone formation, cartilage, chondrocyte, osteoblast, CaSR knockout, unfixed fracture, fracture healing
Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection
Nutrients (MDPI) South Korea, 08 September 2019
Immunology
Key words: Gut health, Probiotics, Caenorhabditis elegans, Epithelial barrier infection [more]
Organism: Mouse
Tissue: Colon
Pathological State: Worm Infestation
Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation
The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, Germany, 05 September 2019
Cardiology
Organism: Mouse
Tissue: Heart
ATMIN is a tumor suppressor gene in lung adenocarcinoma
Cancer Research (AACR Publications) UK, 03 September 2019
Oncology
Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer
Oncogene (Nature) Taiwan, 02 September 2019
Oncology
Key words: Cancer therapeutic resistance, Tumor angiogenesis [more]
Organism: Mouse
Tissue: Blood Vessels
Pathological State: Cancer
Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models
Cancers (MDPI) South Korea, 31 August 2019
Oncology
Key words: glioblastoma, patient-derived glioblastoma stem-like cells, semi- and pseudotyped-retroviral replicating vector, dual suicide gene therapy, bystander effect [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain
The FASEB Journal (FASEB) Germany, Switzerland, 30 August 2019
Neuroscience
Key words: PHD, HIF, VEGF, Adrenomedullin, Cerebral angiogenesis [more]
Organism: Mouse
Tissue: Brain
Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics
Cells (MDPI) Singapore, 26 August 2019
Pulmonology
Key words: influenza, pneumonia, lung regeneration, stem cells, comparative quantification, P63, KRT5, proliferating alveolar type II cells, proteomics [more]
Organism: Mouse
Tissue: Lung
Pathological State: Pneumonia
Macrophage HIF‐2α regulates tumor‐suppressive Spint1 in the tumor microenvironment
Molecular Carcinogenesis (Wiley) Germany, 22 August 2019
Oncology
Key words: HAI‐1, HGF, hypoxia, proliferation, tumor‐associated macrophages [more]
Organism: Mouse
Tissue: Lung, Xenograft Tumor
Pathological State: Cancer
Nononcogenic restoration of the intestinal barrier by E. coli–delivered human EGF
The Journal of Clinical Investigation (Am Soc Clin Investig) South Korea, 22 August 2019
Microbiology
Organism: Mouse
Tissue: Small Intestine
Pathological State: Colitis
Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity
Experimental Neurology (Elsevier) China, 20 August 2019
Neuroscience
Key words: Hypoxia-ischemia(HI), Neuroprotection, Brain injuries, Hippocampus, Toll-like receptor 4, Rat model [more]
Organism: Rat
Tissue: Brain
Pathological State: Cerebral Ischemia
Microstimulation of primate neocortex targeting striosomes induces negative decision-making
European Journal of Neuroscience (Wiley) USA, 20 August 2019
Neuroscience
Key words: anterior cingulate cortex, approach-avoidance, microstimulation, orbitofrontal cortex, striatum [more]
Organism: Monkey
Tissue: Brain
IL‐10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis
The Journal of Pathology (Wiley) Taiwan, 16 August 2019
Reproductive Medicine
Key words: Angiogenesis, Endometriosis, IL-10, Plasmacytoid dendritic cell, Zebrafish [more]
Organism: Human, Mouse
Tissue: Endometrium
Pathological State: Endometriosis
Targeting the IL-17 receptor using liposomal spherical nucleic acids as topical therapy for psoriasis
Journal of Investigative Dermatology (Elsevier) USA, 15 August 2019
Dermatology
Pathological State: Psoriasis
JAK‐STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression
International Journal of Cancer (Wiley) Austria, Hungary, 12 August 2019
Oncology
Key words: non-small cell lung cancer, lung adenocarcinoma (AC), Kirsten rat sarcoma viral proto-oncogene (K-RAS), Janus kinase (JAK), ruxolitinib, cell-line derived xenografts, genetically engineered mouse models, tumor microenvironment (TME), tumor promotinginflammation [more]
Organism: Mouse
Tissue: Lung, Xenograft Tumor
Pathological State: Cancer
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway
Life Science (Elsevier) China, 11 August 2019
Cardiology
Key words: Resveratrol, Chronic intermittent hypoxia, Cardiac hypertrophy, mTOR [more]
Organism: Rat
Tissue: Heart
Pathological State: Cardiac Hypertrophy
Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys
Journal of Autoimmunity (Elsevier) UK, 09 August 2019
Immunology
Key words: IgA nephropathy (IgAN), PEBP4, Urine, Proteomics, Biomarker, B-Cells [more]
Organism: Human
Tissue: Kidney
Pathological State: IgA nephropathy
Antibiotics drive microbial imbalance and vitiligo development in mice
Journal of Investigative Dermatology (Elsevier) USA, Kazakhstan, 09 August 2019
Dermatology
Key words: Vitiligo, Microbiome, Pseudomonas, T cells [more]
Organism: Mouse
Tissue: Small Intestine, Colon
Pathological State: Vitiligo
Overexpression of Histone H3 Lysine 27 Trimethylation Is Associated with Aggressiveness and Dedifferentiation of Thyroid Cancer
Endocrine Pathology (Springer) Taiwan, 08 August 2019
Oncology
Key words: H3K27me3, EZH2, Thyroid cancer, Immunohistochemistry [more]
Organism: Human
Tissue: Thyroid
Pathological State: Cancer
Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15
Aging Cell (Wiley) USA, 06 August 2019
Cell Biology
Key words: Colon organoids, Colorectal cancer, GDF15, microenivronment, senescence [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment
Cancers (MDPI) Taiwan, 06 August 2019
Oncology
Key words: vascular endothelial growth factor-C, CXC chemokine receptor 2, lymphovascular niche, myeloid-derived suppressor cells [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Analysis of Telomere Lengths in p53 Signatures and Incidental Serous Tubal Intraepithelial Carcinomas Without Concurrent Ovarian Cancer
The American journal Surgical Pathology (Wolters Kluwer) USA, 01 August 2019
Oncology
Key words: ovarian cancer precursor, fallopian tube, p53 signature, serous tubal intraepithelial carcinoma, telomere
Increased ILC3s associated with higher levels of IL-1 aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase
European Journal of Immunology (Wiley) Taiwan, Japan, USA, 26 July 2019
Rheumatology
Key words: Innate lymphoid cells, Chronic granulomatous disease, NADPH oxidase, Reactive oxygen species, Serum-induced arthritis [more]
Organism: Mouse
Tissue: Bone, Connective Tissue
Pathological State: Arthritis
Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns
Food and Chemical Toxicology (Elsevier) Taiwan, USA, 26 July 2019
Toxicology
Key words: Di-(2-ethylhexyl) phthalate, Intravenous infusion, Microbiota, Anti-HBsAg-IgM, Newborn
An Amyloid-β Targeting Chemical Exchange Saturation Transfer Probe for In Vivo Detection of Alzheimer's Disease
ACS Chemical Neuroscience (ACS Publications) China, 25 July 2019
Neuroscience
Key words: Alzheimer’s disease, Amyloid-β, Magnetic resonance imaging, Chemical exchange saturation transfer, Angiopep-2 [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer's disease
Synergistic effect of NELL-1 and an ultra-low dose of BMP-2 on spinal fusion
Tissue Engineering Part A (Mary Ann Liebert Inc.) Singapore, China, 24 July 2019
Regenerative Medicine
Organism: Pig
Cell Line: BMSC
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
Nature Communications (Nature) Italy, France, USA, UK, 24 July 2019
Oncology
Key words: Cancer, Molecular biology [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing
Cancer Research (AACR Publications) China, 22 July 2019
Oncology
Key words: HCC, DIS3L2, hnRNP U, Alternative splicing, Rac1b [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus
Journal of Endocrinology (bioscientifica) Ireland, 18 July 2019
Reproductive Medicine
Key words: Uterus, Endometrium, Androgen, SARM, Andarine, GTx-024, Enobosarm, 15 Ostarine, Danazol, DHT [more]
Organism: Mouse
Tissue: Uterus
Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis
Molecular Neurobiology (Springer) Taiwan, USA, 18 July 2019
Neuroscience
Key words: Sp1, Astrocyte, Neurite outgrowth, Synaptogenesis [more]
Organism: Mouse
Tissue: Brain
Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction
Basic Research in Cardiology (Springer) Austria, 16 July 2019
Cardiology
Key words: ST-segment elevation myocardial infarction, Neutrophil extracellular traps, Fibrocytes Thrombosis [more]
Organism: Human
Tissue: Heart
Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface
Nature Communications (Nature) UK, 16 July 2019
Microbiology, Immunology
Key words: Infection, Innate immunity, Pathogens, Respiratory tract diseases [more]
Organism: Human
Pathological State: Streptococcus Infection
Cell Line: Mucosal cells
B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease
Journal of Allergy and Clinical Immunology (Elsevier) Italy, USA, Japan, 15 July 2019
Allergy Research
Key words: IgG4, IgG4-related disease, B cells, plasmablasts, fibrosis, fibroblasts, rituximab, lysyl oxidase homolog 2, plateletderived growth factor [more]
Organism: Human
Tissue: Pancreas, Lymphoid Tissue,
Pathological State: IgG4-Related Disease
Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond
Cancer Microenvironment (Springer) Austria, 11 July 2019
Oncology
Key words: IL-6, EMT, JAK/STAT3/Snail signalling, radiochemotherapy, therapy resistance, conditioned medium [more]
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
The Lymphoma-Associated Macrophages-To-Hodgkin-Reed-Sternberg Cells Ratio Is A Poor Prognostic Factor In Classic Hodgkin Lymphoma Patients
Clinical Lymphoma Myeloma and Leukemia (Elsevier) Czech Republic, 05 July 2019
Oncology
Key words: Hodgkin lymphoma, macrophage, prognosis, microenvironment [more]
Organism: Human
Pathological State: Cancer