Customer Publications (A total of 2312 papers published)
The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology (BMC) South Africa, USA, 01 July 2022
Immunology
Key words: Follicular regulatory T cells (TFRs), Follicular helper T (TFH) cells, Lymph node, Biomarkers, HIV [more]
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: HIV Infection
Mutations in GCK May Lead to MODY2 by Reducing Glycogen Synthesis
Advanced Biology (Wiley) China, 30 June 2022
Endocrinology
Cell Line: HepG2 cells
An optimized method for obtaining clinical‐grade specific cell subpopulations from human umbilical cord‐derived mesenchymal stem cells
Cell Proliferation (Wiley) China, 29 June 2022
Biological Methods
Organism: Human
Cell Line: hUC-MSCs
The long-term survival and functional maturation of human iNPC-derived neurons in the basal forebrain of cynomolgus monkeys
Life Medicine (Oxford Academic) China, 28 June 2022
Stem Cell Research, Neuroscience
Key words: Non-human primates, Cerebral cell transplantation, Human induced neural stem/progenitor cells, Neuronal differentiation, Functional maturation [more]
Organism: Cynomolgus Monkey
Tissue: Brain
Hepatitis B virus X gene impacts on the innate immunity and immune‐tolerant phase in chronic hepatitis B virus infection
Liver International (Wiley) Taiwan, 28 June 2022
Hepathology, Immunology
Organism: Human
Tissue: Liver
Pathological State: Chronic hepatitis B
Cancer-Associated Fibroblasts Promote Tumor Aggressiveness in Head and Neck Cancer through Chemokine Ligand 11 and CC Motif Chemokine Receptor 3 Signaling Circuit
Cancers (MDPI) Taiwan, 27 June 2022
Oncology
Key words: head and neck cancer, cancer-associated fibroblasts, CCL11, CCR3, tumor microenvironment [more]
Pathological State: Cancer
Cell Line: FaDu cell lines (HTB-43 - ATCC)
Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure
Particle and Fibre Toxicology (BMC) China, USA, 23 June 2022
Pulmonology
Key words: Particle matter, Chronic lung injuries, Single-cell RNA sequencing, IL-17A, Myeloid-derived suppressor cells [more]
Organism: Mouse
Tissue: Lung
Pathological State: Pulmonary Fibrosis
Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment
Journal of Advanced Research (Elsevier) Taiwan, 22 June 2022
Oncology, Pharmacology
Key words: Cancer, Drug design, HDAC6/HSP90 dual inhibitor, Immunosensitizer, Tumor microenvironment [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis
Genes & Diseases (Elsevier) China, 21 June 2022
Ophthalmology
Key words: Apoptosis, Glaucoma, Phagocytosis, PLSCR1, Retinal ganglion cells [more]
Organism: Mouse
Tissue: Eye
Pathological State: Glaucoma
A diagnostic pitfall; small cell carcinoma-like features in basaloid squamous cell carcinoma of the esophagus
Histology and Histopathology (Griffith University) Japan, Australia, Germany, 21 June 2022
Oncology
Key words: esophagus, biopsy, basaloid squamous cell carcinoma, small cell carcinoma, diagnostic pitfall [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer's Disease
International Journal of Molecular Sciences (MDPI) Taiwan, USA, France, 20 June 2022
Neuroscience, Pharmacology
Key words: neurodegenerative disease, Alzheimer’s disease (AD), passive immunotherapy, encapsulated cell therapy, microtube array membrane (MTAMs) [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer's Disease
Clinical value of urinary cytokines/chemokines as prognostic markers in patients with crescentic glomerulonephritis
Scientific reports (Nature) South Korea, 17 June 2022
Nephrology
Key words: Chemokines, Cytokines, Kidney diseases [more]
Organism: Human
Tissue: Kidney
Pathological State: Crescentic Glomerulonephritis
Decreased CD11c‐positive dendritic cells in the tumor microenvironment predict double‐hit/triple‐hit genotype and survival in diffuse large B‐cell lymphoma
The Journal of Pathology: Clinical Research (Wiley) Taiwan, 17 June 2022
Oncology
Key words: high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, double-hit lymphoma, triple-hit lymphoma, diffuse large B-cell lymphoma, tumor microenvironment, dendritic cell, decision curve analysis [more]
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: Cancer
Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF‐κB pathway
Cell Proliferation (Wiley) China, 16 June 2022
Osteology
Organism: Mouse
Tissue: Bone
Pathological State: Osteoporosis
Evaluation of Topical and Subconjunctival Injection of Hyaluronic Acid-Coated Nanoparticles for Drug Delivery to Posterior Eye
Pharmaceutics (MDPI) Taiwan, China, 13 June 2022
Nanomedicine
Key words: posterior eye, hyaluronic acid, surface charges, nanoparticles, drug delivery, eyedrops, subconjunctival injection, retina [more]
Organism: Mouse
Tissue: Eye
Occurrence of Lymphangiogenesis in Peripheral Nerve Autografts Contrasts Schwann Cell-Induced Apoptosis of Lymphatic Endothelial Cells In Vitro
Biomolecules (MDPI) Austria, Germany, 12 June 2022
Neuroscience
Key words: peripheral nerve regeneration, lymphangiogenesis, Schwann cells, lymphatic endothelial cells [more]
Cell Line: Fibrin hydrogels containing Schwann cell, lymphatic endothelial cells and adipose-derived stem cells
Accumulation of Cytotoxic Skin Resident Memory T Cells and Increased Expression of IL-15 in Lesional Skin of Polymorphic Light Eruption
Frontiers in Medicine (Frontiers Media S.A.) France, Austria, 10 June 2022
Dermatology, Allergy Research
Key words: sun allergy, polymorphic light eruption, disease recurrence, inflammation, disease memory, resident memory T cell (TrM) [more]
Organism: Human
Tissue: Skin
Pathological State: Polymorphic light eruption (PLE)
A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells
Cancers (MDPI) Sweden, Australia, 10 June 2022
Oncology
Key words: colorectal liver metastases, tumor-infiltrating lymphocytes, tissue-resident memory T cells, patient-derived xenograft model, MEK inhibition [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Long‐term outcomes of arterial ischemia or venous occlusion on vascularized groin lymph nodes in a rat model
Journal of Surgical Oncology (Wiley) Taiwan, Austria, 09 June 2022
Angiology
Key words: arterial ischemia, lymphedema, vascularized lymph node transfer, venous congestion [more]
Organism: Rat
Tissue: Lymphoid Tissue
Pathological State: Arterial ischemia
Proteomic analysis of hepatic fibrosis induced by a high starch diet in largemouth bass (Micropterus salmoides)
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics (Elsevier) China, 08 June 2022
Zoology, Endocrinology
Key words: High starch diet, Hepatic fibrosis, Proteomics, PRM, Micropterus salmoides [more]
Organism: Bass Fish
Tissue: Liver
Pathological State: Hepatic fibrosis
Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5
Cell Death Discovery (Nature) China, 07 June 2022
Oncology
Key words: Cancer, Oncogenesis [more]
Organism: Human
Tissue: Uterus
Pathological State: Cancer
Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses
Cell Reports (Cell Press) China, 07 June 2022
Immunology
Key words: OTUD3, RIG-I, MDA5, cGAS, deubiquitination, innate immunity [more]
Organism: Mouse
Tissue: Lung
Pathological State: Virus Infection
Loss of core-fucosylation of SPARC impairs collagen binding and contributes to COPD
Cellular and Molecular Life Sciences (Springer) Taiwan, 07 June 2022
Pulmonology
Key words: COPD, Fut8, Core-fucosylation, SPARC, Matricellular protein, Collagen [more]
Organism: Human
Tissue: Lung
Pathological State: Chronic obstructive pulmonary disease
Diffusion tensor imaging reveals brain structure changes in dogs after spinal cord injury
Neural Regeneration Research (Publishing House of Neural Regeneration Research) China, 06 June 2022
Neuroscience
Key words: spinal cord injury, diffusion tensor imaging, canines, pathophysiology, cerebrospinal structures, corticospinal tract, magnetic resonance imaging, anisotropic fraction, apparent dispersion coefficient [more]
Organism: Dog
Tissue: Brain
Pathological State: Spinal cord injury
Fecal Microbiota Transfer Attenuates Gut Dysbiosis and Functional Deficits After Traumatic Brain Injury
Shock (Wolters Kluwer) USA, 06 June 2022
Neuroscience, Gastroenterology
Key words: Traumatic brain injury, fecal microbiome transplantation, microbiome, dysbiosis, trauma, controlled cortical impact, behavior, anxiety [more]
Organism: Mouse
Tissue: Brain
Pathological State: Traumatic Brain Injury
FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1
Journal of Cellular and Molecular Medicine (Wiley) China, 03 June 2022
Oncology
Key words: FOXM1, glycolysis, nasopharyngeal carcinoma, PDK1, proliferation [more]
Organism: Human
Tissue: Nasal Mucosa
Pathological State: Cancer
A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer
Advanced Biology (Wiley) China, 02 June 2022
Oncology
Organism: Human
Cell Line: HCC cells
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma
International Journal of Oncology (Spandidos Publications) China, 31 May 2022
Oncology
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Ultra-Fine Polyethylene Hernia Meshes Improve Biocompatibility and Reduce Intraperitoneal Adhesions in IPOM Position in Animal Models
Biomedicines (MDPI) Germany, 31 May 2022
Tissue Engineering
Key words: polyethylene mesh, biocompatibility, IPOM, ultrafine diameter filaments, adhesion formation, animal trials [more]
Tissue: Surgical mesh
Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice
Brain Sciences (MDPI) China, USA, 30 May 2022
Neuroscience, Gastroenterology
Key words: microbiota-gut-brain axis, brain aging, gut microbiota, Atp11b, aging pathology [more]
Organism: Mouse
Tissue: Brain
Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway
Investigative Ophthalmology & Visual Science (ARVO Journals) China, 26 May 2022
Ophthalmology
Organism: Human
Tissue: Meibomian Gland
Catalpol Attenuates Pulmonary Fibrosis by Inhibiting Ang II/AT1 and TGF-β/Smad-Mediated Epithelial Mesenchymal Transition
Frontiers in Medicine (Frontiers Media S.A.) China, 24 May 2022
Pulmonology
Key words: idiopathic pulmonary fibrosis, Ang II, TGF-β/Smad signaling pathway, EMT, catalpol [more]
Organism: Mouse
Tissue: Lung
Pathological State: Pulmonary Fibrosis
Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications
Nanomaterials (MDPI) Romania, 24 May 2022
Nanomedicine
Key words: polyhistidine copolymers, micelles, doxorubicin, tumor cells, release studies [more]
Cell Line: Micelles
Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma
Journal for ImmunoTherapy of Cancer (BMJ Journals) USA, 23 May 2022
Oncology, Immunology
Key words: Brain Neoplasms, Central Nervous System Neoplasms, Drug Evaluation, Preclinical, Programmed Cell Death 1 Receptor, Vaccination [more]
Organism: Human
Cell Line: DTG-IDH1 cells
Tumor acidity-responsive polymeric nanoparticles to promote intracellular delivery of zoledronic acid by PEG detachment and positive charge exposure for enhanced antitumor potency
Journal of Materials Chemistry B (Royal Society of Chemistry) Taiwan, 23 May 2022
Nanomedicine
Key words: Endocrinology [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Adverse Effects of Single Neutrophil Extracellular Trap-Derived Components on Bovine Sperm Function
Animals (MDPI) Chile, Germany, 20 May 2022
Reproductive Medicine, Zoology
Key words: bovine, spermatozoon, bull, neutrophil extracellular traps, membrane integrity [more]
Organism: Cattle
Cell Line: polymorphonuclear neutrophils, Spermatozoa
Topography-Mediated Enhancement of Nonviral Gene Delivery in Stem Cells
Pharmaceutics (MDPI) China, The Netherlands, 20 May 2022
Pharmacology
Key words: topography, proliferation, gene delivery, endocytosis, transfection [more]
Organism: Human
Cell Line: hBM-MSCs
Di-(2-ethylhexyl) Phthalate Promotes Allergic Lung Inflammation by Modulating CD8α+ Dendritic Cell Differentiation via Metabolite MEHP-PPARγ Axis
Frontiers in Immunology (Frontiers Media S.A.) Taiwan, USA, 19 May 2022
Immunology
Key words: allergic lung inflammation, dendritic cell, PPAR γ, low-dose exposure, di-(2-ethylhexyl) phthalate, mono-(2-ethylhexyl) phthalate (MEHP) [more]
Organism: Mouse
Tissue: Lung
Pathological State: Allergic Lung Inflammation
Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts
Nature Communications (Nature) China, 19 May 2022
Oncology
Key words: Cancer immunotherapy, Cancer therapeutic resistance, Drug delivery [more]
Organism: Mouse
Tissue: Liver
Pathological State: Cancer
Concurrent Germline and Somatic Mutations in FLCN and Preliminary Exploration of Its Function: A Case Report
Frontiers in Oncology (Frontiers Media S.A.) China, 19 May 2022
Oncology
Key words: Birt-Hogg-Dube (BHD) syndrome, folliculin (FLCN), mutation, renal cancer, TFEB/TFE3 [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Combination neoantigen-based dendritic cell vaccination and adoptive T-cell transfer induces antitumor responses against recurrence of hepatocellular carcinoma
Cancer Immunology Research (AACR Publications) China, 18 May 2022
Oncology, Immunology
Organism: Human
Tissue: Liver
Pathological State: Cancer
Adenosine ameliorated Aβ25− 35-induced brain injury through the inhibition of apoptosis and oxidative stress via an ERα pathway
Brain Research (Elsevier) China, 18 May 2022
Neuroscience
Key words: Adenosine, Brain injury, ERα, Apoptosis, Oxidative stress [more]
Organism: Mouse
Tissue: Brain
Pathological State: Brain injury
Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells
Journal of The American Society of Nephrology (ASN) UK, Austria, Italy, Australia, USA, France, Denmark, 17 May 2022
Endocrinology
Key words: calcium-sensing receptor, mineral metabolism, vascular calcification, hypercalcemia, transgenic mouse, vascular smooth muscle [more]
Organism: Mouse
Tissue: Kidney
Downregulated ADAMTS1 Incorporating A2M Contributes to Tumorigenesis and Alters Tumor Immune Microenvironment in Lung Adenocarcinoma
Biology (MDPI) Taiwan, 16 May 2022
Oncology
Key words: A2M, ADAMTS1, EMT, immunity, LUAD, metastasis [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Organ‐specific immune response in lethal SARS‐CoV‐2 infection by deep spatial phenotyping
Clinical & Translational Immunology (Wiley) Singapore, 15 May 2022
SARS-CoV-2, Immunology
Key words: COVID-19, immunopathology, in situ spatial multiplexing, SARS-CoV-2 infection [more]
Organism: Human
Tissue: Lung, Small Intestine, Heart
Pathological State: COVID-19
Translocon-associated protein subunit SSR3 determines and predicts susceptibility to paclitaxel in breast cancer and glioblastoma
Clinical Cancer Research (AACR Publications) USA, Germany, Hungary, 12 May 2022
Oncology
Key words: Paclitaxel, biomarker, glioblastoma, breast cancer, SSR3 [more]
Organism: Mouse
Tissue: Breast
Pathological State: Cancer
Novel Elastic Threads for Intestinal Anastomoses: Feasibility and Mechanical Evaluation in a Porcine and Rabbit Model
International Journal of Molecular Sciences (MDPI) Germany, The Netherlands, 11 May 2022
Tissue Engineering
Key words: biomaterial, TPU, surgical thread, suture material, elastic suture, gastrointestinal anastomosis
Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG4-related disease and Kimura disease
Journal of Allergy and Clinical Immunology (Elsevier) Japan, USA, Italy, 11 May 2022
Immunology
Key words: Single-cell RNA sequencing, IgG4-related disease, IgG4-RD, IgG4, IgE, Tfh cell, B cell, interleukin-10, class switch, fibrosis [more]
Organism: Human
Tissue: Salivary Gland
Pathological State: IgG4-related disease and Kimura disease
In vitro testicular toxicity of environmentally relevant endocrine-disrupting chemicals: 2D vs. 3D models of prepubertal Leydig TM3 cells
Environmental Toxicology and Pharmacology (Elsevier) Czech Republic, 10 May 2022
Reproductive Medicine, Toxicology
Key words: 3D in vitro models, Endocrine-disrupting chemicals, Leydig cells, Lipotoxicity, Reproductive toxicity, Spheroids [more]
Tissue: Spheroid
Cell Line: Leydig TM3 cells
AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice—A Pilot Study
International Journal of Molecular Sciences (MDPI) Austria, Germany, 09 May 2022
Oncology, Gastroenterology
Key words: aged mice, colitis associated colorectal cancer, AOM, DSS, mouse strain differences, pilot study [more]
Organism: Mouse
Tissue: Colon
Pathological State: Cancer
Hybrid PEGylated chitosan/PLGA nanoparticles designed as pH-responsive vehicles to promote intracellular drug delivery and cancer chemotherapy
International Journal of Biological Macromolecules (Elsevier) Taiwan, 05 May 2022
Nanomedicine, Oncology
Key words: Acidity-responsive nanovehicles, PEGylated chitosan, cancer chemotherapy [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Multinucleated Retinal Pigment Epithelial Cells Adapt to Vision and Exhibit Increased DNA Damage Response
Cells (MDPI) China, 05 May 2022
Key words: multinucleation, retinal pigment epithelium, reactive oxygen species, photoreceptor, DNA damage, p53 [more]
Organism: Mouse
Tissue: Eye
Macrophage-associated immune checkpoint CD47 blocking ameliorates endometriosis
Molecular Human Reproduction (Oxford Academic) China, 05 May 2022
Reproductive Medicine
Key words: apoptosis, endometriosis, immune checkpoint, immunotherapy, macrophage, phagocytosis [more]
Organism: Human
Tissue: Endometrium
Pathological State: Endometriosis
DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide
Mutation Research/Genetic Toxicology and Environmental Mutagenesis (Elsevier) Brazil, 05 May 2022
Toxicology
Key words: XP-V, Temozolomide, Polymerase eta, DNA damage, Translesion synthesis, Cisplatin [more]
Organism: Human
Cell Line: TLS-deficient cell line XP30RO
miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization
Carcinogenesis (Oxford Academic) China, 02 May 2022
Oncology
Key words: Tiam1, breast cancer, metastasis, glucose metabolism reprogramming, miR-21-5p [more]
Organism: Human
Cell Line: BC cell lines
SAM and folic acid prevent arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells by modulating expression of inflammatory and DNA repair genes
Chemico-Biological Interactions (Elsevier) Thailand, 02 May 2022
Toxicology
Key words: Arsenic, S-adenosyl methionine (SAM), Folic acid, DNA methylation, 8-hydroxydeoxyguanosine (8-OHdG), 8-nitroguanine [more]
Organism: Human
Cell Line: Lymphoblast cells (RPMI 1788)
Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse
Investigative Ophthalmology & Visual Science (ARVO Journals) China, UK, 02 May 2022
Ophthalmology, Neuroscience
Organism: Mouse
Tissue: Eye
ITGB1 Suppresses Autophagy Through Inhibiting The mTORC2/AKT Signaling Pathway In H9C2 Cells
Die Pharmazie-An International Journal of Pharmaceutical Sciences (Avoxa - Mediengruppe Deutscher Apotheker GmbH) China, 01 May 2022
Pharmacology
Organism: Rat
Tissue: Heart
Prognostic Value of Characterizing Myocardial Tissue by Cardiac MRI with T1 Mapping in HFpEF Patients: A Systematic Review and Meta-Analysis
Journal of Clinical Medicine (MDPI) Russia, 30 April 2022
Cardiology
Key words: cardiac MRI, HFpEF, T1 mapping, extracellular volume, native T1, postcontrast T1, prognosis
The Overexpression of Insulin-Like Growth Factor-1 and Neurotrophin-3 Promote Functional Recovery and Alleviate Spasticity After Spinal Cord Injury
Frontiers in Neuroscience (Frontiers Media S.A.) China, 29 April 2022
Neuroscience
Key words: spinal cord injury, nerve repair, nerve growth factor, NT-3, IGF-1, motor function recovery, spasticity, mechanical pain [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Epidermotropism of inflammatory cells differentiates pyoderma gangrenosum from venous leg ulcers
Journal of the German Society of Dermatology (Wiley) Germany, 29 April 2022
Dermatology
Organism: Human
Tissue: Skin
Pathological State: Ulcer
Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model
Neoplasia (Elsevier) Taiwan, 29 April 2022
Oncology
Key words: MLL translocation, KRAS mutation, Hoxa11, Hoxa10, Myeloid sarcoma, Migration [more]
Organism: Mouse
Cell Line: Mouse MLL/AF10 leukemia cell lines
Prognostic values of B7-H3, B7-H4, and HHLA2 expression in human pancreatic cancer tissues based on mIHC and spatial distribution analysis
Pathology-Research and Practice (Elsevier) China, 29 April 2022
Oncology
Key words: B7-H3, B7-H4, HHLA2, Multi-color immunohistochemistry, Prognosis, Pancreatic cancer [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma
Cancers (MDPI) Germany, The Netherlands, USA, UK, 27 April 2022
Oncology
Key words: cholangiocarcinoma, liver cancer, tumor microenvironment, nerve fiber density, immune checkpoint, immune cells [more]
Organism: Human
Tissue: Bile duct
Pathological State: Cancer
Corallodiscus flabellata BL Burtt extract and isonuomioside A ameliorate Aβ25− 35-induced brain injury by inhibiting apoptosis, oxidative stress, and autophagy via the NMDAR2B/CamK Ⅱ/PKG pathway
Phytomedicine (Elsevier) China, 27 April 2022
Toxicology
Key words: Isonuomioside A, Corallodiscus flabellata B. L. Burtt extract, NMDAR2B, Apoptosis, Oxidative stress, Autophagy [more]
Organism: Mouse
Tissue: Brain
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target
Science Signaling (Science) Brazil, USA, 26 April 2022
Pharmacology
Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site
Microbiology Spectrum (ASM Journals) China, 25 April 2022
Microbiology, Neuroscience
Organism: Mouse
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Oxidative Stress-Induced Growth Inhibitor (OSGIN1), a Target of X-Box-Binding Protein 1, Protects Palmitic Acid-Induced Vascular Lipotoxicity through Maintaining Autophagy
Biomedicines (MDPI) Taiwan, 25 April 2022
Cell Biology
Key words: palmitic acid, OSGIN1, unfolded protein response, XBP1s, autophagy, eNOS, endothelial cells [more]
Organism: Human
Tissue: Blood Vessels
Pathological State: Atherosclerosis
HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer
Nature Genetics (Nature) USA, 25 April 2022
Oncology
Key words: Epigenomics, Prostate cancer, Targeted therapies [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
HLA class I downregulation in progressing metastases of melanoma patients treated with ipilimumab
Pathology and Oncology Research (Elsevier) Hungary, Austria, USA, 22 April 2022
Oncology
Key words: immunotherapy, melanoma, ipilimumab, HLA class I expression, longitudinal study [more]
Organism: Human
Tissue: Skin
Pathological State: Cancer
Increased fatty acid metabolism attenuates cardiac resistance to β-adrenoceptor activation via mitochondrial reactive oxygen species: A potential mechanism of hypoglycemia-induced myocardial injury in diabetes
Redox Biology (Elsevier) China, 21 April 2022
Endocrinology
Key words: Hypoglycemia, Diabetes, Lipid metabolism, β-adrenoceptor, Mitochondrial reactive oxygen species [more]
Organism: Mouse
Tissue: Heart
CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by
International Journal of Biological Sciences (Ivyspring International Publisher) China, 20 April 2022
Cardiology, Oncology
Key words: CIRBP, Cardioprotection, OGFR, Chemotherapy-induced cardiotoxicity, Cardiomyocyte apoptosis [more]
Organism: Mouse
Tissue: Heart
CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis
Journal of Inflammation Research (Dovepress) China, 20 April 2022
Pulmonology
Key words: chronic obstructive pulmonary disease, emphysema, B cell, bioinformatics analysis [more]
Organism: Human
Tissue: Lung
Pathological State: Chronic obstructive pulmonary disease
Endocrine-disrupting chemicals affect sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro
Food and Chemical Toxicology (Elsevier) Czech Republic, 19 April 2022
Reproductive Medicine
Key words: Connexins, Endocrine-disrupting chemicals, Gap junctional intercellular communication, Reproductive toxicity, Sertoli cells, Testicular tumors [more]
Organism: Human
Cell Line: Sertoli TM4 cells
Computer-assisted evaluation enhances the quantification of interstitial fibrosis in renal implantation biopsies, measures differences between frozen and paraffin sections, and predicts delayed graft function
Journal of Nephrology (Springer) Austria, France, 19 April 2022
Medical Image Analysis
Key words: Implantation biopsy, Interstitial fibrosis, Computer-assisted evaluation, Delayed graft function [more]
Organism: Human
Tissue: Kidney
Pathological State: Interstitial fibrosis
Robust delivery of RIG‐I agonists using extracellular vesicles for anti‐cancer immunotherapy
Journal of Extracellular Vesicles (Wiley) Singapore, 16 April 2022
Oncology
Organism: Mouse
Tissue: Lung, Xenograft Tumor
Pathological State: Cancer
Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging
Magnetic Resonance Imaging (Elsevier) Japan, 16 April 2022
Medical Imaging
Key words: Breast cancer, Magnetic resonance imaging, Diffusion weighted imaging, Diffusion kurtosis imaging, Histology [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
The significance of NAD+ metabolites and nicotinamide N-methyltransferase in chronic kidney disease
Scientific Reports (Nature) Japan, 16 April 2022
Nephrology
Key words: Medical research, Nephrology [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Kidney Disease
Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway
Journal of Experimental & Clinical Cancer Research (BMC) China, 15 April 2022
Oncology
Key words: Esophageal squamous cell carcinoma, IL-32, Extracellular vesicle, M2 macrophage polarization, Metastasis [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice
Carbohydrate Polymers (Elsevier) China, 14 April 2022
Gastroenterology
Key words: Polysaccharides, Molecular weight, Prebiotic fiber, Protection, Dysbiosis [more]
Organism: Mouse
Tissue: Colon
Pathological State: Dysbiosis
AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia
International Journal of Molecular Sciences (MDPI) Spain, Austria, 13 April 2022
Oncology
Key words: neuroblastoma, calcium-sensing receptor, calcimimetic, cinacalcet, AC-265347, biased signaling, differentiation, cancer-testis antigens [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
A phase 1b study of OXIRI in pancreatic adenocarcinoma patients and its immunomodulatory effects
International Journal of Cancer (Wiley) Singapore, 12 April 2022
Oncology
Key words: PDAC, OXIRI, metronomic oxaliplatin, chronomodulated capecitabine, UGT1A1, irinotecan [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy
Cell Death & Disease (Nature) China, 12 April 2022
Ophthalmology
Key words: Apoptosis, Cell death [more]
Organism: Mouse
Tissue: Eye
Pathological State: Diabetes, Retinopathy
Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome
Molecules (MDPI) China, 12 April 2022
Neuroscience
Key words: eriodictyol, homoeriodictyol, NLRP3 inflammasome, Alzheimer’s disease, Aβ25–35 [more]
Organism: Mouse
Tissue: Brain
Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy
Theranostics (Ivyspring International Publisher) Singapore, Hong Kong, China, 11 April 2022
Oncology
Organism: Mouse
Tissue: Spleen
Pathological State: Cancer
ERBB2D16 Expression in HER2 Positive Gastric Cancer Is Associated With Resistance to Trastuzumab.
Frontiers in Oncology (Frontiers Media S.A.) China, 07 April 2022
Oncology
Key words: gastric cancer, ERBB2d16, epithelial-mesenchymal transition, immunosuppression, trastuzumab resistance [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
Rho kinase inhibition ameliorates vascular remodeling and blood pressure elevations in a rat model of apatinib-induced hypertension
Journal of Hypertension (Wolters Kluwer) China, 07 April 2022
Cardiology
Key words: RhoA/Rho-associated coiled-coil domain-containing protein kinase signaling pathway, apatinib, hypertension, tyrosine kinase inhibitors, vascular endothelial growth factor
Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis
Nature Biomedical Engineering (Nature) China, Israel, 07 April 2022
Nanomedicine, Gastroenterology
Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice
Communications Biology (Nature) China, 06 April 2022
Neuroscience
Key words: 3-D reconstruction, Fluorescence imaging, Light-sheet microscopy, Neural circuits, Viral tracing [more]
Organism: Mouse
Tissue: Brain
Inhibition of CXXC5 function reverses obesity‐related metabolic diseases
Clinical and Translational Medicine (Wiley) South Korea, 05 April 2022
Endocrinology
Organism: Mouse
Tissue: Pancreas
Pathological State: Obesity
Inhibiting MNK kinases promotes macrophage immunosuppressive phenotype to limit CD8+ T cell anti-tumor immunity
JCI Insight (American Society for Clinical Investigation) USA, 05 April 2022
Immunology, Oncology
Key words: MNK kinases, tumor-associated macrophages, CD8+ T cells, immunotherapy, antiPD-1 antibody, anti-CSF-1R antibody, pancreatic cancer, thyroid cancer [more]
Organism: Human
Tissue: Thyroid
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques
Protein & cell (Springer) China, 04 April 2022
SARS-CoV-2, Immunology
Key words: SARS-CoV-2, NRP1, inflammation, central nervous system, viral encephalitis, rhesus macaque [more]
Organism: Rhesus Macaques
Tissue: Lung
Pathological State: COVID-19
KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion
EBioMedicine (Elsevier) China, Sweden, 01 April 2022
Cell Biology, Neuroscience
Key words: Extracellular vesicles, Lysosomes, KIBRA, Amyloid β, Alzheimer's disease [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer's disease
Extracellular Vesicles Derived from SIPA1high Breast Cancer Cells Enhance Macrophage Infiltration and Cancer Metastasis through Myosin-9
Biology (MDPI) China, Japan, 31 March 2022
Oncology
Key words: breast cancer, extracellular vesicles, macrophage, myosin-9, SIPA1 [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Prenatal infection predisposes offspring to enhanced susceptibility to imiquimod-mediated psoriasiform dermatitis in mice
Dermatologica Sinica (Taiwanese Society for Investigative Dermatology) Taiwan, 30 March 2022
Dermatology
Key words: Bacterial infection, lipopolysaccharide, polyinosinic:polycytidylic acid, psoriasis, psoriatic arthritis, viral infection [more]
Organism: Mouse
Tissue: Skin
Pathological State: Psoriasis
Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology (Elsevier) USA, Japan, 29 March 2022
SARS-CoV-2, Immunology
Key words: COVID-19, CD8+ T cells, Cytotoxic CD4+ T cells [more]
Organism: Human
Tissue: Lung, Lymphoid Tissue
Pathological State: COVID-19
FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway
The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 29 March 2022
Oncology
Organism: Mouse
Tissue: Ovaries, Xenograft Tumor
Pathological State: Cancer
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration
Cell Death & Differentiation (Nature) China, 28 March 2022
Ophthalmology
Key words: Drug development, Epigenetics [more]
Organism: Mouse
Tissue: Eye
Food Allergen Nitration Enhances Safety and Efficacy of Oral Immunotherapy in Food Allergy
Nutrients (MDPI) Austria, 25 March 2022
Allergy Research
Key words: oral immunotherapy, food allergy, protein nitration, modulated immune response [more]
Organism: Mouse
Tissue: Stomach
Pathological State: Allergy
Effects of Magnetite Nanoparticles and Static Magnetic Field on Neural Differentiation of Pluripotent Stem Cells
Stem Cell Reviews and Reports (Springer) Brazil, USA, 24 March 2022
Stem Cell Research, Nanomedicine
Key words: Neural differentiation, Magnetic nanoparticles, Magnetic field, Biomagnetic effects, Embryonic stem cells, iPSCs, Dopaminergic neurons [more]
Organism: Human
Cell Line: Induced dopaminergic neurons
Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells Mitigate Endoplasmic Reticulum Stress, Inflammation, and Lung Injury in Lipopolysaccharide-Treated Obese Mice
Antioxidants (MDPI) Taiwan, Vietnam, 23 March 2022
Endocrinology
Key words: lung injury, obesity, endoplasmic reticulum stress, exosomes, LPS [more]
Organism: Mouse
Tissue: Lung
Pathological State: Obesity
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway
Frontiers in Oncology (Frontiers Media S.A.) China, 22 March 2022
Oncology, Pharmacology
Key words: gracillin, non-small cell lung cancer, autophagy, mTOR signaling pathway, anti-tumor [more]
Organism: Mouse
Tissue: Heart, Liver, Kidney, Lung, Xenograft Tumor
Pathological State: Cancer
A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer
Journal of Biomedical Science (BMC) Taiwan, USA, 22 March 2022
Oncology
Key words: STAT1, Colorectal cancer, Stemness, Angiogenesis, 4’,5,7-trihydroxyisoflavone (THIF), BODIPY-THIF [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model
Cancers (MDPI) Germany, 17 March 2022
Radiotherapy
Key words: 53BP1, cell death, DNA damage, epidermis, γ-H2AX, proton minibeam radiation therapy, DNA repair, skin model [more]
Organism: Human
Cell Line: Human reconstructed epidermis (epiCS®) models
Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis
Nature communications (Nature) China, Taiwan, 16 March 2022
Oncology
Key words: Breast cancer, Cancer stem cells, Cancer therapy, Metastasis, Tumour heterogeneity [more]
Organism: Human
Tissue: Breast, Lymphoid Tissue
Pathological State: Cancer
Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway
Nature Cell Biology (Nature) China, 15 March 2022
Oncology
Key words: Glycoproteins, Mechanisms of disease, Pancreatic cancer [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Regorafenib Reverses Temozolomide-Induced CXCL12/CXCR4 Signaling and Triggers Apoptosis Mechanism in Glioblastoma
Neurotherapeutics (Springer) Taiwan, 10 March 2022
Oncology
Key words: Glioblastoma, Temozolomide, Regorafenib, NF-κB, CXCR4/CXCL12 [more]
Organism: Mouse
Tissue: Brain, Xenograft Tumor
Pathological State: Cancer
hsa-miR-875-5p inhibits tumorigenesis and suppresses TGF-β signalling by targeting USF2 in gastric cancer
Journal of Translational Medicine (Springer) China, 07 March 2022
Oncology
Key words: miR-875-5p, USF2, Gastric cancer, TGF-β [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy
ACS NANO (ACS Publications) China, 03 March 2022
Oncology
Key words: Nitric oxide, Immunogenic cell death, NO nanogenerator, Vaccination effects, PD-1 blockade therapy [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Low miR-10b-3p associated with sorafenib resistance in hepatocellular carcinoma
British Journal of Cancer (Nature) Taiwan, USA, 02 March 2022
Oncology
Key words: Hepatocellular carcinoma, Tumour biomarkers [more]
Organism: Mouse
Tissue: Liver, Xenograft Tumor
Pathological State: Cancer
Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin
Cell Reports (Cell Press) USA, 01 March 2022
Oncology
Key words: Gα13, KC mouse model, KPC mouse model, Human PDAC tumors, E-cadherin, mTOR, Rapamycin [more]
Organism: Mouse
Tissue: Pancreas
Pathological State: Cancer
Immunoarchitectural patterns as potential prognostic factors for invasive ductal breast cancer
npj Breast Cancer (Nature) China, 28 February 2022
Oncology
Key words: Breast cancer, Prognostic markers [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma
Experimental Cell Research (Elsevier) Austria, 25 February 2022
Oncology
Key words: Mesenchymal-to-epithelial transition, Cell-transfection, TissueFax, UPCI-SCC090, SCC25, FaDu [more]
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus
EBioMedicine (Elsevier) Germany, Austria, 25 February 2022
Neuroscience
Key words: Alzheimer's disease, Plasma extracellular vesicles, Choroid plexus, Hippocampus, Hyaluronan, Hyaluronic acid synthetase, Secretases, BACE, Aβ, APP [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer's disease
Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms
Free Radical Biology and Medicine (Elsevier) China, 24 February 2022
Neuroscience
Key words: Iron, Ischemic stroke, Gliosis, Synaptic plasticity, Myelination, Nerve regeneration [more]
Organism: Mouse
Tissue: Brain
Pathological State: Stroke
Tumor Necrosis Factor-α Mediates Lung Injury in the Early Phase of Endotoxemia
Pharmaceuticals (MDPI) Taiwan, Australia, 24 February 2022
Pulmonology
Key words: lung injury, endotoxin, cytokines, cytokine receptors, peptide, mice [more]
Organism: Mouse
Tissue: Lung
Pathological State: Endotoxemia
Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation
Advanced Biology (Wiley) China, Australia, 23 February 2022
SARS-CoV-2, Osteology
Organism: Human
Pathological State: SARS-CoV-2 Infection
Cell Line: Bone marrow cells
High farnesoid X receptor expression predicts favorable clinical outcomes in PD‑L1low/negative non‑small cell lung cancer patients receiving anti‑PD‑1‑based chemo‑immunotherapy
International Journal of Oncology (Spandidos Publications) China, 23 February 2022
Oncology
Key words: Farnesoid X receptor, Predictor, anti‑PD‑1‑based, Chemo‑immunotherapy, Non‑small cell lung cancer, PD‑L1low/negative patients [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Prompt Antiviral Action of Pulmonary CD8+ TRM Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung
Frontiers in Immunology (Frontiers Media S.A.) China, 22 February 2022
Immunology
Key words: influenza, lung-resident memory CD8 T cells, IFN-γ, interferon-induced genes, inflammatory cytokines [more]
Organism: Mouse
Tissue: Lung
Pathological State: Influenza Infection
Meloxicam Inhibits Hepatocellular Carcinoma Progression and Enhances the Sensitivity of Immunotherapy via the MicroRNA-200/PD-L1 Pathway
Journal of Oncology (Hindawi Publishing Corporation) China, 21 February 2022
Oncology
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
TSPAN6 is a suppressor of Ras-driven cancer
Oncogene (Nature) Australia, Austria, Germany, Canada, 19 February 2022
Oncology
Key words: Cancer genetic, Cell polarity, Growth factor signalling [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects
Stem Cell Research & Therapy (Springer) Taiwan, USA, 19 February 2022
Osteology
Key words: Melatonin, Dental pulp mesenchymal stem cells, Osteogenesis, COX2/NF-κB, p38/ERK signaling pathwaym, Bone regeneration, Calvarial bone defect [more]
Organism: Rabbit
Tissue: Bone
The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells
Elife (eLife Sciences Publications) China, 18 February 2022
Neuroscience
Organism: Mouse
Tissue: Brain
Imaging net retrograde axonal transport in vivo: a physiological biomarker
Annals of Neurology (Wiley) USA, 17 February 2022
Medical Imaging
Organism: Mouse
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Cordycerebroside A inhibits ICAM‐1‐dependent M1 monocyte adhesion to osteoarthritis synovial fibroblasts
Journal of Food Biochemistry (Wiley) Taiwan, 15 February 2022
Rheumatology
Key words: Adhesion, Cordycerebroside A, ICAM-1, M1 macrophage, Osteoarthritis [more]
Organism: Human, Rat
Tissue: Joint Tissue
Quantitative Characterization of Macrophage, Lymphocyte, and Neutrophil Subtypes Within the Foreign Body Granuloma of Human Mesh Explants by 5-Marker Multiplex Fluorescence Microscopy
Frontiers in Medicine (Frontiers Media S.A.) Germany, 15 February 2022
Medical Image Analysis
Key words: Foreign body granuloma, Mesh, Multiplex, Fluorescence, Macrophage, Lymphocyte, Neutrophil [more]
Organism: Human
Tissue: Surgical mesh
A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+ CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy
International Journal of Oral Science (Nature) China, 14 February 2022
Oncology
Key words: Cancer microenvironment, Head and neck cancer [more]
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Cell-Penetrating Botulinum Neurotoxin Type A With Improved Cellular Uptake and Therapeutic Index
Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) China, 11 February 2022
Biological Methods, Neuroscience
Key words: Cell-penetrating peptides, Zinc finger proteins, Botulinum neurotoxin type A, Cellular uptake, Therapeutic index [more]
Organism: Mouse
Tissue: Muscle
H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice
Journal of Affective Disorders (Elsevier) China, 10 February 2022
Neuroscience
Key words: Chronic stress stimulated depression model, Hippocampus, Hydrogen sulfide, Inflammatory, Aerobic exercise [more]
Organism: Mouse
Tissue: Brain
Pathological State: Depression
The effects of hypoxia on mitochondrial function and metabolism in gastric cancer cells
Translational Cancer Research (AME Publishing Company) China, 10 February 2022
Oncology
Key words: Gastric cancer, Hypoxia, Mitochondrial function, Aerobic respiration [more]
Organism: Mouse
Pathological State: Cancer
Cell Line: Gastric cancer line MKN45
MYC/MAX-Activated LINC00958 Promotes Lung Adenocarcinoma by Oncogenic Transcriptional Reprogramming Through HOXA1 Activation.
Frontiers in Oncology (Frontiers Media S.A.) China, 09 February 2022
Oncology
Key words: Lung adenocarcinoma, LINC00958, MYC, MAX, Transcriptional reprogramming, HOXA1 [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Colonic Leucine-Rich Repeat Kinase 2 Expression Is Increased and Associated With Disease Severity in Patients With Parkinson's Disease
Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 08 February 2022
Neuroscience
Key words: Parkinson’s disease, Colon biopsy, Leucine-rich repeat kinase 2, Inflammatory bowel diseases, Biomarker (BM) [more]
Organism: Human
Tissue: Colon
Pathological State: Parkinson's disease
Differential localization and limited cytotoxic potential of duodenal CD8+ T cells
JCI Insight (American Society for Clinical Investigation) Malawi, South Africa, UK, USA, 08 February 2022
Immunology
Organism: Human
Tissue: Small Intestine
Assessment of Physiological Rat Kidney Ageing—Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation
Metabolites (MDPI) Germany, 08 February 2022
Transplantation Medicine, Nephrology
Key words: Kidney, Ageing, Transplantation, Inflammation, Urinary metabolites [more]
Organism: Rat
Tissue: Kidney
ATP8B1 Knockdown Activated the Choline Metabolism Pathway and Induced High-Level Intracellular REDOX Homeostasis in Lung Squamous Cell Carcinoma
Cancers (MDPI) China, 07 February 2022
Oncology
Key words: ATP8B1, LUSC, CHKA, REDOX [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Multi-Factorial Nerve Guidance Conduit Engineering Improves Outcomes in Inflammation, Angiogenesis and Large Defect Nerve Repair
Matrix Biology (Elsevier) Ireland, USA, 04 February 2022
Neuroscience
Key words: Peripheral Nerve, Biomaterials, Extracellular Matrix, Nerve Guidance Conduit, Angiogenesis, Inflammation [more]
Organism: Rat
Tissue: Nerves
Effect of Helicobacter pylori-associated chronic gastritis on autonomous activity and sleep quality in mice
Frontiers in Pharmacology (Frontiers Media S.A.) China, 04 February 2022
Microbiology, Gastroenterology
Key words: Autonomous activity, Chronic gastritis, Helicobacter pylori, Mouse behavior, Sleep quality [more]
Organism: Mouse
Tissue: Stomach
Pathological State: Gastritis
Tegaserod Maleate Inhibits Breast Cancer Progression and Enhances the Sensitivity of Immunotherapy
Journal of Oncology (Hindawi Publishing Corporation) China, Germany, 03 February 2022
Oncology, Pharmacology
Organism: Mouse
Tissue: Xenograft Tumor, Lung
Pathological State: Cancer
Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype
Cancer Research (AACR Publications) USA, 02 February 2022
Oncology, Immunology
Organism: Mouse
Tissue: Xenograft Tumor, Lung
Pathological State: Cancer
Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues
Scientific Reports (Nature) Japan, 02 February 2022
Biological Methods
Key words: Assay systems, Biotechnology [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond
PNAS (United States National Academy of Sciences) China, 01 February 2022
Oncology
Key words: Tumor Tissue, Histological Magnetometry, Nitrogen-Vacancy Center, Micrometer-Resolution Magnetic Imaging, Absolute Magnetic Quantification [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through β-catenin dysregulation
Cellular and Molecular Life Sciences (Springer) South Korea, 28 January 2022
Cardiology
Key words: PRMT7, Cardiomyopathy, Wnt, β-catenin [more]
Organism: Rat
Pathological State: Cardiac Fibrosis
Cell Line: Neonatal rat ventricular myocyte (NRVM) cells
Regorafenib enhances antitumor immune efficacy of anti-PD-L1 immunotherapy on oral squamous cell carcinoma
Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 26 January 2022
Oncology, Pharmacology
Key words: Oral squamous cells carcinoma, Regorafenib, Anti-PD-L1, Antitumor-induced immunity [more]
Organism: Mouse
Tissue: Mucosa
Pathological State: Cancer
Metastatic Tumor Antigen 1 Contributes to Hepatocarcinogenesis Posttranscriptionally Through Novel RNA Binding Function
Hepatology (Wiley) Taiwan, 24 January 2022
Oncology
Key words: RNA stability, Post-transcriptional control, Tumorigenic capacity, Self-renewal and anchorage-independent growth, Carcinogenesis [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach
Cellular and Molecular Gastroenterology and Hepatology (Elsevier) Singapore, Japan, 21 January 2022
Stem Cell Research, Gastroenterology
Key words: Isthmus, Stem/Progenitor Cell, Enhanced Stem Cell Activity, Preneoplastic State, Gastric Carcinogenesis [more]
Organism: Mouse
Tissue: Stomach
Inhibition of β-catenin signaling attenuates arteriovenous fistula thickening in mice by suppressing myofibroblasts
Molecular Medicine (BMC) Taiwan, USA, 21 January 2022
Nephrology
Key words: Arteriovenous fistula (AVF), β-catenin, Hemodialysis, Myofibroblast [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Kidney disease
Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT
Prostate Cancer and Prostatic Diseases (Nature) USA, 20 January 2022
Oncology
Key words: Cancer therapy, Prostate cancer [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
Chidamide and mitomycin C exert synergistic cytotoxic effects against bladder cancer cells in vitro and suppress tumor growth in a rat bladder cancer model
Cancer Letters (Elsevier) Taiwan, 18 January 2022
Oncology
Key words: Urothelial carcinoma, Histone, N-methyl-N-nitrosourea, Deacetylase, Axl [more]
Organism: Rat
Tissue: Bladder
Pathological State: Cancer
Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response
mBio (American Society for Microbiology) Singapore, 18 January 2022
SARS-CoV-2, Immunology
Organism: Human
Pathological State: COVID-19
Cell Line: human nasal epithelial stem/progenitor cells (hNESPCs)
Repair phase modeling of ischemic acute kidney injury: recovery vs. transition to chronic kidney disease
American Journal of Translational Research (e-Century Publishing Corporation) South Korea, 15 January 2022
Nephrology
Key words: Ischemic acute kidney injury, Chronic kidney disease, Ischemia-reperfusion injury, Recovery, Repair [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Kidney Disease
P2RX7 in dopaminergic neurons of ventral periaqueductal gray mediates HTWP acupuncture-induced consciousness in traumatic brain injury
Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China, USA, 13 January 2022
Neuroscience
Key words: Acupuncture, Traumatic Brain Injury, Neural Projection, Dopamine, P2RX7, Ventral Periaqueductal Gray, Hand 12 Jing-Well Points [more]
Organism: Rat
Tissue: Brain
Pathological State: Traumatic Brain Injury
Cottonseed protein concentrate as fishmeal alternative for largemouth bass (Micropterus salmoides) supplemented a yeast-based paraprobiotic: Effects on growth performance, gut health and microbiome
Aquaculture (Elsevier) China, France, 13 January 2022
Zoology
Key words: Cottonseed Protein Concentrate, Largemouth Bass, Paraprobiotic, Gut Health, Gut Microbiome [more]
Organism: Bass Fish
Tissue: Small Intestine
Pathological State: Alzheimer's Disease
Autochthonous Human Dirofilaria repens Infection in Austria
Acta Parasitologica (Springer) Austria, 12 January 2022
Parasitology
Key words: Dirofilariasis · Nematode infections · Parasitic worms · Climate change · Austria [more]
Organism: D. repens
Tissue: Whole Organism
Large deletion of Wdr19 in developing renal tubules disrupts primary ciliogenesis leading to polycystic kidney disease in mice
The Journal of Pathology (Wiley) Taiwan, 10 January 2022
Nephrology
Key words: Wdr19, intraflagellar transport, primary cilia, renal cyst, polycystic kidney disease [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Kidney Disease
Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease
Stem Cell Reviews and Reports (Springer) Brazil, China, 08 January 2022
Neuroscience, Stem Cell Research
Key words: Alzheimer’s Disease, Hippocampus, Neural and Mesenchymal Stem Cell Transplantation, Tissue Cytometry, Amyloid-β plaques [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer's Disease
Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin
Journal of Cachexia, Sarcopenia and Muscle (Wiley) Belgium, 07 January 2022
Infectious Diseases, Endocrinology
Key words: Leptin, Critical Illness, Sepsis, Muscle Weakness, Intensive Care Unit Acquired Weakness, Atrophy, Protein Catabolism [more]
Organism: Mouse
Tissue: Muscle
Pathological State: Sepsis, Obesity
Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection
Blood Advances (ASH Publications) South Africa, USA, Germany, 06 January 2022
Immunology
Key words: Immunobiology, Immunotherapy [more]
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: HIV Infection
Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity
OncoImmunology (Taylor & Francis) China, 05 January 2022
Oncology
Key words: CMTM6, DNA Damage, Cellular Senescence, Immunity, Renal Cell Carcinoma [more]
Organism: Human
Pathological State: Cancer
Cell Line: HKC cells, ccRCC cells, HEK293T cells
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages
Cellular & molecular Immunology (Nature) China, 04 January 2022
SARS-CoV-2, Immunology
Key words: SARS-CoV-2, Microparticles, Alveolar Macrophages, Endosomes, Lysosomes [more]
Organism: Mouse
Tissue: Lung
Pathological State: COVID-19
Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes
Regenerative Biomaterials (Chinese Society for Biomaterials) Taiwan, 04 January 2022
Stem Cell Research
Key words: Chondrocytes, Cell Proliferation, Perichondrial Progenitor Cells, Paracrine Effect, Neocartilage Formation [more]
Organism: Mouse
Tissue: Joint Tissue
Stabilization but no functional influence of HIF-1α expression in the intestinal epithelium during Salmonella Typhimurium infection
Infection and Immunity (American Society for Microbiology) Germany, The Netherlands, 03 January 2022
Immunology, Microbiology
Organism: Mouse
Tissue: Small Intestine, Large Intestine
Pathological State: Salmonella Typhimurium infection
Preclinical Safety of a 3D-Printed Hydroxyapatite-Demineralized Bone Matrix Scaffold for Spinal Fusion
Spine (ingentaconnect) USA, 01 January 2022
Osteology
Key words: 3D Printing, Bone Morphogenetic Protein-2, Demineralized Bone Matrix, Host Inflammatory Response, Hydroxyapatite, Spinal Fusion [more]
Organism: Rat
Tissue: Bone
Detection of Cytopathic Effects Induced by Influenza, Parainfluenza, and Enterovirus Using Deep Convolution Neural Network
Biomedicines (MDPI) Taiwan, 28 December 2021
Machine Learning, Virology
Key words: Artificial Intelligence, Cytopathic Effect, ResNet-50
The liquid Kangfuxin (KFX) has efficient antifungal activity and can be used in the treatment of vulvovaginal candidiasis in mouse
Letters in Applied Microbiology (Wiley) China, 27 December 2021
Infectious Diseases, Reproductive Medicine
Key words: Candida Albicans, Kangfuxin Liquid, Antifungal, Vaginal Candidiasis, Murine Model [more]
Organism: Mouse
Tissue: Vagina
Pathological State: Candidiasis
Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice
Pharmaceuticals (MDPI) Taiwan, 27 December 2021
Endocrinology
Key words: Obesity, Sepsis, Liver, Exosomes, let-7i [more]
Organism: Mouse
Tissue: Liver
Pathological State: Obesity
Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis
Systems biology in Reproductive Medicine (Taylor & Francis) China, 27 December 2021
Reproductive Medicine
Key words: Letrozole, Endometriosis, Endometrial Receptivity, Integrin avβ3, HOXA10 [more]
Organism: Rat
Tissue: Endometrium
Pathological State: Endometriosis
Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells
International Journal of Molecular Sciences (MDPI) Austria, Poland, 24 December 2021
Endocrinology, Oncology
Key words: Vitamin D, Vitamin D Analogs, 25 Vitamin D 24-Hydroxylase, CYP24A1, Proliferation, High-Grade Serous Ovarian Cancer Cells [more]
Organism: Human
Pathological State: Cancer
Cell Line: Ovarian cancer cells
Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression
Cells (MDPI) Taiwan, 20 December 2021
Oncology
Key words: Glioma, Chondroitin Sulfate, CHSY1, Integrin Β1, CD44, Therapeutic Peptide
S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 …
The American Journal of Pathology (Elsevier) Japan, 20 December 2021
Oncology
Organism: Human
Pathological State: Cancer
Cell Line: Peripheral blood monocytes
Spatial point pattern analysis identifies mechanisms shaping the skin parasite landscape in Leishmania donovani infection
Frontiers in Immunology (Frontiers Media S.A.) UK, 16 December 2021
Parasitology
Key words: Leishmania donovani, host cell, dispersion, dispersal, skin patches, spatial point pattern analysis [more]
Organism: Mouse
Tissue: Skin
Pathological State: Leishmaniasis
P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease
Chinese Medicine (Springer) China, 16 December 2021
Gastroenterology
Key words: P2Y12 Receptor, Visceral Pain, Depression, EA, IBD [more]
Organism: Mouse
Tissue: Brain
Pathological State: depression, inflammatory bowel disease
Hedgehog-signalling in papillary fibroblasts is essential for hair follicle regeneration during wound healing
Journal of Investigative Dermatology (Elsevier) Austria, 16 December 2021
Dermatology
Key words: Wound Healing, Dermal Fibroblast Lineages, Hedgehog Signaling, Hair Follicle Neogenesis, WIHN, Papillary and Reticular Fibroblasts, Regeneration [more]
Organism: Mouse
Tissue: Skin
Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma
International Journal of Immunpathology and Pharmacology (SAGE Journals) China, 15 December 2021
Oncology
Key words: Clear Cell Renal Cell Carcinoma, NEK2, Prognosis [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
CD163+ M2 macrophages promote fibrosis in IgG4‐related disease via TLR7/IRAK4/NF‐κB signaling
Arthritis & Rheumatology (Wiley) Japan, Bangladesh, 15 December 2021
Immunology, Rheumatology
Key words: Igg4-Related Disease, M2 Macrophage, Toll-Like Receptor 7, IL-1 Receptor-Associated Kinase 4, Fibrosis [more]
Organism: Human
Tissue: Salivary Gland
Pathological State: IgG4-Related Disease
Nuplazid suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting PAK4
British Journal of Cancer (Nature) China, 15 December 2021
Oncology
Key words: Cancer Prevention [more]
Organism: Mouse
Tissue: Xenograft Tumor, Esophagus
Pathological State: Cancer
A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice
Journal of Virology (American Society for Microbiology) China, 15 December 2021
SARS-CoV-2
Key words: COVID-19, Vaccine, SARS-CoV-2 Variants, Influenza, Adenoviral Vector [more]
Organism: Mouse
Tissue: Lung
Pathological State: COVID-19
Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy (Cell Press) China, 15 December 2021
Oncology
Key words: Tim-3, Tim-3 Ligands, Immune Checkpoint Blockade, Tumor Microenvironment, Multiplexed Immunofluorescence [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response
Nature Communications (Nature) Taiwan, 15 December 2021
Oncology, Immunology
Key words: Cancer Immunotherapy, Colon Cancer, Gene Silencing, Immunoediting [more]
Organism: Mouse
Tissue: Colon
Pathological State: Cancer
Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells
PNAS (United States National Academy of Sciences) China, 14 December 2021
SARS-CoV-2
Organism: Human
Pathological State: COVID-19
Cell Line: WT A549 cells
Polypharmacological reprogramming of tumor-associated macrophages towards an inflammatory phenotype
Cancer Research (AACR Publications) USA, 13 December 2021
Oncology
Key words: Tumor-Associated Macrophage, Breast Cancer, Tumor Microenvironment, Kinase Inhibitor Screening, Cell-Cell Interaction [more]
Organism: Mouse
Tissue: Allograft Tumor, Lung
Pathological State: Cancer
The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model
JOR Spine (Wiley) USA, 13 December 2021
Rheumatology
Key words: Local Steroid, Osteogenesis, Pseudarthrosis, Spine Fusion [more]
Organism: Mouse
Tissue: Bone
Pathological State: Spinal arthrodesis
The plasminogen receptor Plg‐RKT regulates adipose function and metabolic homeostasis
Journal of Thrombosis and Haemostasis (Wiley) USA, Austria, 12 December 2021
Endocrinology
Key words: Adipose Inflammation, Hepatic Steatosis, Insulin Resistance, Obesity, Plg-RKT [more]
Organism: Human
Tissue: Adipose Tissue
Pathological State: Obesity
Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension
Frontiers in Physiology (Frontiers Media S.A.) China, 10 December 2021
Gastroenterology
Key words: Intra-Abdominal Hypertension, Abdominal Compartment Syndrome, Fecal Microbiota Transplantation, 16S rRNA, Gut Microbiota Dysbiosis [more]
Organism: Rat
Tissue: Liver
Pathological State: Liver Injury
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1
Nature Cancer (Nature) China, 09 December 2021
Oncology
Organism: Mouse
Tissue: Liver
Pathological State: Cancer
FGL1 as a Novel Mediator and Biomarker of Malignant Progression in Clear Cell Renal Cell Carcinoma.
Frontiers in Oncology (Frontiers Media S.A.) China, 09 December 2021
Oncology
Key words: biomarker, clear cell renal cell carcinoma, epithelial to mesenchymal transition, fibrinogen-like protein 1, progression [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
CD146 as a Prognostic-Related Biomarker in ccRCC Correlating With Immune Infiltrates
Frontiers in Oncology (Frontiers Media S.A.) China, 08 December 2021
Oncology
Key words: CD146, ccRCC, prognosis, methylation, tumor microenvironment [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Lipid Droplet-Specific Probe for Rapidly Locating Atherosclerotic Plaques and Intraoperative Imaging via In Situ Spraying
ACS Applied Materials & Interfaces (ACS Publications) China, 06 December 2021
Biological Methods
Key words: Lipids, Liquids, Fluorescence, Fluorescence Imaging, Probes [more]
Organism: Mouse
Tissue: Blood Vessels
Pathological State: Atherosclerosis
Hedgehog signaling controls bone homeostasis by regulating osteogenic/adipogenic fate of skeletal stem/progenitor cells in mice
Journal of Bone and Mineral Research (Wiley) China, 06 December 2021
Osteology, Stem Cell Research
Key words: Genetic Animal Models, Hedgehogs, Stromal/Stem Cells, Osteoporosis, Aging [more]
Organism: Mouse
Tissue: Bone
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients
Signal Transduction and Targeted Therapy (Nature) China, 06 December 2021
SARS-CoV-2
Key words: Drug Development, Infectious Diseases [more]
Organism: Monkey
Tissue: Brain, Lung
Pathological State: COVID-19
Ascorbic acid-2 glucoside mitigates intestinal damage during pelvic radiotherapy in a rat bladder tumor model
International Journal of Radiation Biology (Taylor & Francis) Japan, Germany, 06 December 2021
Oncology, Radiotherapy
Key words: AY-27 Cells, DNA Damage, 53BP1, CD163, M1/M2, Macrophages [more]
Organism: Rat
Tissue: Bladder
Pathological State: Cancer
Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration
Free Radical Biology and Medicine (Elsevier) China, 04 December 2021
Cell Biology
Key words: Age-Related Macular Degeneration, Heterochromatin, Inflammation, Methotrexate, cGAS, STING [more]
Organism: Mouse
Tissue: Eye
Pathological State: Macular degeneration
Defect of LSS Disrupts Lens Development in Cataractogenesis.
Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 02 December 2021
Developmental Biology
Key words: lanosterol synthase, congenital cataract, mouse model, mutation, lens development [more]
Organism: Mouse
Tissue: Eye
Pathological State: Cataract
Mad2 Induced Aneuploidy Contributes to Eml4-Alk Driven Lung Cancer by Generating an Immunosuppressive Environment
Cancers (MDPI) Germany, 30 November 2021
Oncology
Key words: Lung Cancer, Aneuploidy, Tumor Microenvironment, Immune Suppression, Mouse Models [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1
Science Signaling (Science) USA, 30 November 2021
Oncology
Organism: Human
Cell Line: AALE cells
Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy
Molecular Pharmaceutics (ACS Publications) UK, Italy, 29 November 2021
Pharmacology
Key words: Polymer−Drug Conjugate PEG Pregnancy Placenta Transport Drug Delivery [more]
Organism: Human
Tissue: Placenta
Pathological State: Pregnancy
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma
Nature Cancer (Nature) USA, Mexico, France, 29 November 2021
Oncology
Key words: Cancer, Cancer Immunotherapy, CNS Cancer, Tumour Biomarkers [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Single cell imaging-based chromatin biomarkers for tumor progression
Scientific Reports (Nature) Singapore, India, Italy, Switzerland, 29 November 2021
Oncology
Key words: Biomarkers, Biophysics, Cancer, Computational Biology and Bioinformatics [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Lipid‐Activatable Fluorescent Probe for Intraoperative Imaging of Atherosclerotic Plaque Using In Situ Patch
Nano Micro Small (Wiley) China, 27 November 2021
Biological Methods
Organism: Mouse
Tissue: Blood Vessels
Pathological State: Atherosclerosis
HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells
Signal Transduction and Targeted Therapy (Nature) China, 24 November 2021
Oncology
Key words: Cancer, Molecular Biology [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Mechanism of Chronic Stress-Induced Glutamatergic Neuronal Damage in the Basolateral Amygdaloid Nucleus
Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 23 November 2021
Neuroscience
Organism: Rat
Tissue: Brain