Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Filter publications

Customer Publications (A total of 2600 papers published)

201
Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

O Leddy, FM White, BD Bryson

Elife (eLife Sciences Publications) USA, 19 April 2023

Immunology, Virology

Cell Line: Macrophages

202
BushenHuoxue decoction suppresses M1 macrophage polarization and prevents LPS induced inflammatory bone loss by activating AMPK pathway

S Chen, L Tao, F Zhu, Z Wang, Q Zhuang, Y Li, Y Yang, C Feng, H Shi, J Shi, L Zhu, L Xiao, D Geng, Z Wang

Heliyon (Cell Press) China, 19 April 2023

Immunology

Key words: Inflammatory bone loss, Bushen huoxue decoction, Inflammation, Macrophage polarization, Bone immune regulation

Organism: Mouse

Tissue: Bone

203
Targeting YAP1 ameliorates progesterone resistance in endometriosis

SC Lin, WN Li, SC Lin, HT Hou, YC Tsai, TC Lin, MH Wu, SJ Tsai

Human Reproduction (Oxford Academic) Taiwan, 18 April 2023

Reproductive Medicine

Key words: YAP1, miR-21-5p, PGR, progesterone resistance, endometriosis

Organism: Human

Tissue: Endometrium

Pathological State: Endometriosis

204
IKKα inhibition re-sensitizes acquired adriamycin-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis

J Liao, Q Qin, F Lv, Z Huang, B Lian, C Wei, Q Mo, QX Tan

Scientific Reports (Nature) China, 17 April 2023

Oncology, Pharmacology

Key words: Cancer, Chemical biology, Diseases, Genetics

Organism: Human

Tissue: Breast

Pathological State: Cancer

205
Single-cell transcriptome analysis revealed the immune profile of PD-1 blockade in gallbladder carcinoma liver metastasis

L Xie, Z Ning, Y Hua, P Wang, Z Meng

Hepatology Communications (Wiley) China, 14 April 2023

Oncology

Organism: Human

Tissue: Gallbladder

Pathological State: Cancer

206
Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity

VA Onofrei, E Anisie, CL Zamfir, A Ceasovschih, M Constantin, F Mitu, ED Grigorescu, AD Petroaie, DV Timofte

Journal of Clinical Medicine (MDPI) Romania, 14 April 2023

Endocrinology, Oncology

Key words: arterial stiffness, adipokines, morbid obesity, cardiovascular risk, perivascular adipose tissue

Organism: Human

Tissue: Adipose Tissue

Pathological State: Obesity

207
Adiponectin reverses β‐Cell damage and impaired insulin secretion induced by obesity

AC Munhoz, JDC Serna, EA Vilas‐Boas, CC Caldeira da Silva, TG Santos, FC Mosele, SL Felisbino, VR Martins, AJ Kowaltowski

Aging Cell (Wiley) Brazil, 14 April 2023

Endocrinology

Key words: adiponectin, calorie restriction, diabetes, obesity, oxidative phosphorylation

Organism: Mouse

Tissue: Pancreas

Pathological State: Obesity

208
Upregulation of dendrocyte-expressed seven transmembrane protein is associated with unfavorable outcomes in differentiated thyroid cancer

JJ Lee, YC Hsu, WC Huang, SP Cheng

Endocrine (Springer) Taiwan, 14 April 2023

Oncology, Pharmacology

Key words: DCSTAMP, Recurrence, Survival, Thyroid cancer, Immunohistochemistry

Organism: Human

Tissue: Thyroid

209
The effects of mild hypothermia on the electrode insertion trauma in a murine whole organ cochlea culture

J Schmutzhard, W Bader, T Gottfried, D Dejaco, R Glückert, J Dudas, A Schrott-Fischer

Frontiers in Neuroscience (Frontiers Media S.A.) Austria, 13 April 2023

Pathology

Key words: hypothermia, whole organ cochlea culture, electrode insertion trauma, cochlear implant, sensorineural hearing loss, hearing rehabilitation

Organism: Mouse

Tissue: Ear

210
Yellow mealworm (Tenebrio Molitor) enhances intestinal immunity in largemouth bass (Micropterus salmoides) via the NFκB/survivin signaling pathway

C Ge, X Liang, X Wu, J Wang, H Wang, Y Qin, M Xue

Fish & Shellfish Immunology (Elsevier) China, 11 April 2023

Zoology

Key words: Yellow mealworm, Largemouth bass, Intestinal immunity, NFκBp65, Survivin

Organism: Fish

Tissue: Colon

211
Axonal mapping of motor and sensory components within the ulnar nerve and its branches

V Tereshenko, U Maierhofer, LA Hruby, J Klepetko, DC Dotzauer, O Politikou, G Laengle, M Luft, C Festin, R Blumer, KD Bergmeister, OC Aszmann

Journal of Neurosurgery (American Association of Neurological Surgeons) Austria, 07 April 2023

Neuroscience

Key words: axon count, flexor carpi ulnaris muscle, flexor digitorum profundus muscle, nerve transfer, deep branch of the ulnar nerve, superficial branch of the ulnar nerve, peripheral nerve, anatomy

Organism: Human

Tissue: Nerves

212
Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis

N Das, LGN de Almeida, A Derakhshani, D Young, K Mehdinejadiani, P Salo, A Rezansoff, GD Jay, CP Sommerhoff, TA Schmidt, R Krawetz, A Dufour

Nature Communications (Nature) Canada, USA, Germany, 06 April 2023

Osteology

Key words: Biochemical networks, Proteases, Proteolysis, Rheumatology

Organism: Human

Tissue: Joint Tissue

Pathological State: Osteoarthritis

213
Prognostic values of tissue-resident CD8+ T cells in human hepatocellular carcinoma and intrahepatic cholangiocarcinoma

L Chen, H Huang, Z Huang, J Chen, Y Liu, Y Wu, A Li, J Ge, Z Fang, B Xu, X Zheng, C Wu

World Journal of Surgical Oncology (BMC) China, 06 April 2023

Oncology

Key words: Hepatocellular carcinoma, Intrahepatic Cholangiocarcinoma, Multicolor immunohistochemistry, Prognosis, Tissue-resident CD103+CD8+T cells

Organism: Human

Tissue: Liver

Pathological State: Cancer

214
Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia

Q Jiang, J Stachelscheid, J Bloehdorn, A Pacholewska, C Markus A, F Grotenhuijs, TA Müller, O Onder, P Wagle, CD Herling, M Kleppe, Z Wang, KR Coombes, S Robrecht, PS Dalvi, BA Lungu, P Mayer, LV Abruzzo, J Altmüller, BS Gathof, T Persigehl, K Fischer, BMC Jebaraj, H Young Rienhoff Jr, RC Ecker, Y Zhao, CJ Bruns, S Stilgenbauer, KSJ Elenitoba-Johnson, M Hallek, MR Schweiger, M Odenthal, E Vasyutina, M Herling

Blood (ASH Publications) Germany, USA, China, Romania, Austria, Australia, 06 April 2023

Oncology

Key words: chronic lymphocytic leukemia, TCL1A, KDM1A, epigenetics, histone modulation

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

215
Neuroprotective effects of resistance physical exercise on the APP/PS1 mouse model of Alzheimer's disease

HC Campos, DE Ribeiro, D Hashiguchi, DY Hukuda, C Gimenes, D Suchecki, RM Arida, H Ulrich, B Monteiro Longo

Frontiers in Neuroscience (Frontiers Media S.A.) Brazil, 06 April 2023

Pharmacology, Neuroscience

Key words: Alzheimer’s disease, resistance exercise, locomotor activity, corticosterone, amyloid-beta precursor protein

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s disease

216
Hypoxia switches TET1 from being tumor-suppressive to oncogenic

Q Yang, H Dang, J Liu, X Wang, J Wang, X Lan, M Ji, M Xing, P Hou

Oncogene (Nature) China, 05 April 2023

Oncology

Key words: Cancer microenvironment, Oncogenes

Organism: Mouse

Tissue: Thyroid

Pathological State: Cancer

217
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma

T Zhou, Q Man, X Li, Y Xie, X Hou, H Wang, J Yan, X Wei, W Bai, Z Liu, J Liu, J Hao

Cancer Biology & Medicine (China Anti-Cancer Association) China, 05 April 2023

Oncology, Machine Learning

Key words: Artificial intelligence, CD8, CSCs, tumor budding, PDAC, nomogram

Organism: Human

Tissue: Pancreas

218
Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses

Q Zeng, S Wang, M Li, S Wang, C Guo, X Ruan, R Watanabe, Y Lai, Y Huang, X Yin, C Zhang, B Chen, N Yang, H Zhang

Cell Metabolism (Cell Press) China, Japan, 04 April 2023

Immunology

Key words: CD36, acetylcholine, autoreactive B cell responses, choline acetyltransferase, fibroblastic reticular cells, lipid metabolism, mitochondrial respiration, spleen, systemic lupus erythematosus

Organism: Mouse

Tissue: Spleen

219
Red blood cell extracellular vesicles deliver therapeutic siRNAs to skeletal muscles for treatment of cancer cachexia

B Peng, Y Yang, Z Wu, R Tan, TT Pham, EYM Yeo, M Pirisinu, MK Jayasinghe, TC Pham, K Liang, N Shyh-Chang, MTN Le

Molecular Therapy (Cell Press) Singapore, China, 04 April 2023

Oncology

Key words: extracellular vesicles, cancer cachexia, siRNA, RNA delivery, myostatin, malonyl-CoA decarboxylase

Organism: Mouse

Tissue: Muscle

220
Molecules of senescent glial cells differentiate Alzheimer's disease from ageing

L Dai, F Gao, Q Wang, X Lv, Z Cheng, Y Wu, X Chai, H Zetterberg, K Blennow, AI Levey, J Shi, Y Shen

Journal of Neurology, Neurosurgery & Psychiatry (BMJ Journals) China, Sweden, UK, USA, 04 April 2023

Neuroscience

Organism: Human

Tissue: Brain

Pathological State: Alzheimer's disease

221
Characterization and Advancement of an Evaluation Method for the Treatment of Spontaneous Osteoarthritis in STR/ort Mice: GRGDS Peptides as a Potential Treatment for Osteoarthritis

MF Chen, CC Hu, YH Hsu, YT Chiu, KL Chen, SWN Ueng, Y Chang

Biomedicines (MDPI) Taiwan, 02 April 2023

Osteology

Key words: Osteoarthritis, STR/ort, cartilage, matrix metallopeptidase-13, SRY-box transcription factor 91

Organism: Mouse

Tissue: Joint Tissue

Pathological State: Osteoarthritis

222
A Deep-Learning-Computed Cancer Score for the Identification of Human Hepatocellular Carcinoma Area Based on a Six-Colour Multiplex Immunofluorescence Panel

A Dievernich, J Stegmaier, P Achenbach, S Warkentin, T Braunschweig, UP Neumann, U Klinge

Cells (MDPI) Germany, The Netherlands, 02 April 2023

Osteology, Machine Learning

Key words: hepatocellular carcinoma, HCC, convolutional neural network, CNN, U-net, multiplex, fluorescence, immunofluorescence, microscopy, cancer score

Organism: Human

Tissue: Liver

Pathological State: Cancer

223
Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue

N Chen, M Yuan, NN Zhang, M Chen, R Liu, J Wang, P Lu

iScience (Cell Press) China, 01 April 2023

Cell Biology

Key words: β-catenin, UCP1, thermogenesis, beige adipocytes, energy expenditure

Organism: Mouse

Tissue: Adipose Tissue

224
Analysis of Single-and Double-Stranded DNA Damage in Osteoblastic Cells after Hyperbaric Oxygen Exposure

N Schönrock, F Tillmans, S Sebens, W Kähler, S Klapa, B Rieger, H Scherthan, A Koch

Antioxidants (MDPI) Germany, USA, 01 April 2023

Osteology

Key words: oxidative stress, DNA damage, osteoblasts, gamma-H2AX, hyperbaric hyperoxia, comet assay, DSBs

Cell Line: Primary human osteoblastic cells, Malignant sarcoma osteoblastic cell line - SAOS-2

225
High bacillary burden and the ESX-1 type VII secretion system promote MHC class I presentation by Mycobacterium tuberculosis infected macrophages to CD8 T-cells

D Mott, J Yang, C Baer, K Papavinasasundaram, CM Sassetti, SM Behar

The Journal of Immunology (AHA Journals) USA, 31 March 2023

Immunology, Microbiology

226
DARPP‐32 cells and neuropil define striosomal system and isolated matrix cells in human striatum

CJ Arasaratnam, JJ Song, T Yoshida, MA Curtis, AM Graybiel, RLM Faull, HJ Waldvogel

Journal of Comparative Neurology (Wiley) New Zealand, USA, 31 March 2023

Neuroscience

Key words: DARPP-32, spinyprojectionneurons, striatum, striosomes

Organism: Human

Tissue: Brain

227
Optimizing culturing conditions in patient derived 3D primary slice cultures of head and neck cancer

M do Carmo Greier, A Runge, J Dudas, L Carpentari, VH Schartinger, A Randhawa, M Mayr, M Petersson, H Riechelmann

Frontiers in Oncology (Frontiers Media S.A.) Austria, 30 March 2023

Biological Methods, Oncology

Key words: head and neck cancer, tumor microenvironment, cultured neoplastic cells, platelet rich fibrin, culture media

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

228
Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy

T Dong, ZQ Zhang, LH Sun, W Zhang, Z Zhu, L Lin, Lin Yang, A Lv, C Liu, Q Li, RF Yang, X Zhang, Y Niu, HZ Chen, DP Liu, WM Tong

Brain Pathology (Wiley) China, 28 March 2023

Neuroscience

Key words: antioxidant, Mic60, mitochondria, mitochondrial encephalomyopathies, neurodegeneration, reactive oxygen species

Organism: Mouse

Tissue: Brain

229
CD226 identifies functional CD8+ T cells in the tumor microenvironment and predicts a better outcome for human gastric cancer

H Huang, Z Huang, J Ge, J Yang, J Chen, B Xu, S Wu, X Zheng, L Chen, X Zhang, J Jiang

Frontiers in Immunology (Frontiers Media S.A.) China, 28 March 2023

Oncology, Gastroenterology

Key words: CD226, CD8+ T cells, multi-color immunohistochemical staining, prognosis, gastric cancer

Organism: Human

Tissue: Stomach

Pathological State: Cancer

230
Protective effects of resveratrol on the ethanol‐induced disruption of retinogenesis in pluripotent stem cell‐derived organoids

H Li, L Gao, Z Ye, J Du, W Li, L Liang, Q Zeng, J Xi, W Yue, Z Li

FEBS Open Bio (Wiley) China, 27 March 2023

Ophthalmology

Key words: ethanol, fetal alcohol syndrome, PI3K-AKT signalling, resveratrol, retinal organoids

Cell Line: Human embryonic stem cells

231
Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages

X Li, X Chen, S Gong, J Zhao, C Yao, H Zhu, R Xiao, Y Qin, R Li, N Sun, X Li, F Dong, T Zhao, Y Pan, J Yang

Theranostics (Ivyspring International Publisher) China, 27 March 2023

Immunology, Oncology

Key words: Platelets, TAMs, CRC, PSGL-1/JNK/STAT1, C5a/C5aR1

Organism: Human

Tissue: Colon

Pathological State: Cancer

232
Functional Peptide-Loaded Gelatin Nanoparticles as Eyedrops for Cornea Neovascularization Treatment

YC Chu, HW Fang, YY Wu, YJ Tang, EH Hsieh, Y She, CY Chang, IC Lin, YJ Chen, GS Liu, CL Tseng

International Journal of Nanomedicine (Taylor & Francis) Taiwan, Australia, 23 March 2023

Nanomedicine, Ophthalmology

Key words: gp91 peptide, gelatin, nanoparticles, ocular retention, control release, corneal neovascularization, eye drops

Organism: Mouse

Tissue: Eye

Pathological State: Corneal neovascularization

233
Occurrence, risk assessment, and in vitro and in vivo toxicity of antibiotics in surface water in China

C Zhang, Y Chen, S Chen, X Guan, Y Zhong, Q Yang

Ecotoxicology and Environmental Safety (Elsevier) China, 22 March 2023

Toxicology, Ecology

Key words: Antibiotics, Environmental pollution, Surface water, Intestinal flora, Oxidative stress

Organism: Mouse

Tissue: Liver

234
Dual-Ratiometric Magnetic Resonance Tunable Nanoprobe with Acidic-microenvironment-responsive Property to Enhance the Visualization of Early Tumor Pathological Changes

R Cao, N Tang, Y Zhu, A Chen, Y Li, R Ge, Y Li, Z Huang, J Guo, J Deng, H Lu, Z Lu, H Forgham, TP Davis, R Qiao, Z Wang

Nano Research (Sciopen) China, USA, Australia, 22 March 2023

Nanomedicine, Oncology

Key words: ratiometric nanoprobe, dually activatable, microenvironment visualization, early diagnosis, pathological changes

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

235
Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization

D Chen, N Hu, S Xing, L Yang, F Zhang, S Guo, S Liu, X Ma, X Liang, H Ma

Journal of Ovarian Research (BMC) China, 21 March 2023

Reproductive Medicine

Key words: Placental mesenchymal stem cells, Premature ovarian insufficiency, Macrophage, Inflammasome, NLRP3, Interferon-γ, Pyroptosis

Organism: Rat

Tissue: Ovaries

236
Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy

GS Dunlap, D DiToro, J Henderson, SI Shah, M Manos, M Severgnini, A Weins, I Guleria, PA Ott, N Murakami, DA Rao

Nature Communications (Nature) USA, 21 March 2023

Immunology, Transplantation Medicine

Key words: Graft-versus-host disease, Immunotherapy, Kidney, Transplant immunology, Tumour immunology

Organism: Human

Tissue: Skin, Lymphoid Tissue, Kidney

Pathological State: Graft-versus-host disease

237
Analysis of the Mechanism Underlying Diabetic Wound Healing Acceleration by Calycosin-7-glycoside Using Network Pharmacology and Molecular Docking

J Chen, H Ma, Y Meng, Q Liu, Y Wang, Y Lin, D Yang, W Yao, Y Wang, X He, P Li

Phytomedicine (Elsevier) China, 20 March 2023

Pharmacology

Key words: Diabetic wound healing, Calycosin-7-glucoside, Mitochondrial metabolism, Macrophage polarization, Network pharmacology, Molecular docking

Organism: Mouse

Tissue: Skin

Pathological State: Diabetic wounds

238
Intrinsic RIG-I restrains STAT5 activation to modulate anti-tumor activity of CD8+ T cells

X Jiang, J Lin, C Shangguan, X Wang, B Xiang, J Chen, H Guo, W Zhang, J Zhang, Y Shi, J Zhu, H Yang

The Journal of Clinical Investigation (American Society for Journal of Clinical Investigation) China, 16 March 2023

Immunology, Oncology

Key words: RIG-I, Tumor-infiltrating CD8+ , T cell, STAT5 activation, Colon cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

239
Thorium (IV) Triggers Ferroptosis through Disrupting Iron Homeostasis and Heme Metabolism in the Liver Following Oral Ingestion

M Ma, R Wang, M Xu

Journal of Hazardous Materials (Elsevier) China, 15 March 2023

Hepathology

Key words: Thorium, Hepatotoxicity, Ferroptosis, Iron homeostasis, Heme metabolism

Organism: Mouse

Tissue: Liver

240
Fast and sensitive GCaMP calcium indicators for imaging neural populations

Y Zhang, M Rózsa, Y Liang, D Bushey, Z Wei, J Zheng, D Reep, GJ Broussard, A Tsang, G Tsegaye, S Narayan, CJ Obara, JX Lim, R Patel, R Zhang, MB Ahrens, GC Turner, SSH Wang, WL Korff, ER Schreiter, K Svoboda, JP Hasseman, I Kolb, LL Looger

Nature (Nature) USA, 15 March 2023

Neuroscience

Key words: Fluorescent proteins, Neural circuits

Organism: Mouse

Tissue: Brain

241
Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma

J Chen, K Liu, Y Luo, M Kang, J Wang, G Chen, J Qi, W Wu, B Wang, Y Han, L Shi, K Wang, X Han, X Ma, W Liu, Y Ding, L Wang, H Liang, L Wang, J Chen

Gastroenterology (Elsevier) China, USA, 14 March 2023

Oncology

Key words: Gastric Cancer, T-Cell State, CXCL13, Immune Checkpoint Blockade

Organism: Human

Tissue: Stomach

Pathological State: Cancer

242
Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer

Z Valko, Z Megyesfalvi, A Schwendenwein, C Lang, S Paku, N Barany, B Ferencz, A Horvath-Rozsas, I Kovacs, E Schlegl, V Pozonec, K Boettiger, M Rezeli, G Marko-Varga, F Renyi-Vamos, M Alireza Hoda, T Klikovits, K Hoetzenecker, Michael Grusch, V Laszlo, B Dome, K Schelch

British Journal of Cancer (Nature) Austria, Hungary, Sweden, 14 March 2023

Oncology

Key words: Small-cell lung cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

243
Expression of Checkpoint Molecules in the Tumor Microenvironment of Intrahepatic Cholangiocarcinoma: Implications for Immune Checkpoint Blockade Therapy

L Heij, J Bednarsch, X Tan, M Rosin, S Appinger, K Reichel, D Pecina, M Doukas, RM Van Dam, J Garcia Vallejo, F ulmer, S Lang, T Luedde, FG Rocha, S Sivakumar, UP Neumann

Cells (MDPI) Germany, The Netherlands, USA, UK, 09 March 2023

Oncology, Immunology

Key words: cholangiocarcinoma, tumor microenvironment, checkpoint molecules, multiplexed imaging, immunotherapy

Organism: Human

Tissue: Bile duct, Liver

Pathological State: Cancer

244
Expression of Checkpoint Molecules in the Tumor Microenvironment of Intrahepatic Cholangiocarcinoma: Implications for Immune Checkpoint Blockade …

L Heij, J Bednarsch, X Tan, M Rosin, S Appinger, K Reichel, D Pecina, M Doukas, RM Van Dam, J Garcia Vallejo, F Ulmer, S Lang, T Luedde, FG Rocha, S Sivakumar, UP Neumann

Cells (MDPI) Germany, The Netherlands, USA, UK, 09 March 2023

Oncology, Pharmacology

Key words: cholangiocarcinoma, tumor microenvironment, checkpoint molecules, multiplexed imaging, immunotherapy

Organism: Human

Tissue: Bile duct

Pathological State: Cancer

245
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

VN Hariharan, M Shin, CW Chang, D O'Reilly, A Biscans, K Yamada, Z Guo, M Somasundaran, Q Tang, K Monopoli, PM Krishnamurthy, G Devi, N McHugh, DA Cooper, D Echeverria, J Cruz, IL Chan, P Liu, SY Lim, J McConnell, S Prakash Singh, S Hildebrand, J Sousa, SM Davis, Z Kennedy, C Ferguson, BMD Godinho, Y Thillier, J Caiazzi, S Ly, M Muhuri, K Kelly, F Humphries, A Cousineau, KM Parsi, Q Li, Y Wang, R Maehr, G Gao, D Korkin, WM McDougall, RW Finberg, KA Fitzgerald, JP Wang, JK Watts, A Khvorova

PNAS (Proceedings of the National Academy of Sciences of the United States of America) USA, 09 March 2023

SARS-CoV-2, Immunology

Key words: SARS-COV-2, antisense oligos, small interfering RNAs, mouse model, lung

Organism: Mouse

Tissue: Lung

Pathological State: Covid-19

246
Effects of paraprobiotics on bile acid metabolism and liver health in largemouth bass (Micropterus salmoides) fed a cottonseed protein concentrate-based diet

X Xie, X Liang, H Wang, Q Zhu, J Wang, Y Chang, E Leclercq, M Xue, J Wang

Animal Nutrition (Elsevier) China, France, 07 March 2023

Zoology

Key words: Cottonseed protein concentrate, Multi-yeast strain fractions, Micropterus salmoides, Liver health, Bile acid metabolism, Gut microbiota

Organism: Bass Fish

Tissue: Liver, Small Intestine

247
In Situ Formation of Injectable Gelatin Methacryloyl (GelMA) Hydrogels for Effective Intraocular Delivery of Triamcinolone Acetonide

C Shen, X Zhao, Z Ren, B Yang, X Wang, A Hu, J Hu

International Journal of Molecular Sciences (MDPI) China, 04 March 2023

Pharmacology

Key words: gelatin methacryloyl, triamcinolone acetonide, retina hydrogel system, hydrogel drug release, intraocular drug delivery, injectable gel

Organism: Rabbit

Tissue: Eye

248
The protective effect of cannabinoids against colorectal cancer cachexia through modulation of inflammation and immune responses

SK Ng, DJ Chung, LC Chang, CK Luo, SH Jwo, YH Lee, JS Lin, CH Wang, TT Wei

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 03 March 2023

Immunology, Oncology

Key words: Colorectal cancer cachexia, Cytokines, Cannabinoids, CD8+ T cell, Cannabinoid receptor 2

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

249
Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration

LW Lin, SW Wang, WC Huang, TK Huynh, CY Lai, CY Ko, YC Fong, JJ Lee, SF Yang, CH Tang

Cells (MDPI) Taiwan, 03 March 2023

Aging

Key words: melatonin, endothelial progenitor cells, vascular endothelial growth factor (VEGF), platelet-derived growth factor-BB (PDGF-BB), angiogenesis, neovascular age-related macular degeneration

Cell Line: Endothelial progenitor cells

250
miR-194 upregulates CYP7A1 expression via β-catenin signaling and aggravates cholestatic liver diseases

PC Chen, CP Hsu, SY Wang, TY Wu, YJ Lin, YT Chen, SH Hsu

The American Journal of Pathology (Elsevier) Taiwan, 02 March 2023

Hepathology

Organism: Mouse

Tissue: Liver

251
Androgen therapy does not prevent bone loss and arterial calcifications in male rats with CKD

K David, V Dubois, A Verhulst, V Sommers, D Schollaert, L Deboel, K Moermans, G Carmeliet, P D'Haese, D Vanderschueren, F Claessens, P Evenepoel, B Decallonne

Journal of Endocrinology (Society for Endocrinology) Belgium, 01 March 2023

Endocrinology

Key words: androgen replacement therapy, chronic kidney disease, hypogonadism, bone loss, arterial calcification

Organism: Rat

Tissue: Blood Vessels

Pathological State: Kidney disease

252
Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells

MQ Yan, Y Wang, Z Wang, XH Liu, YM Yang, XY Duan, H Sun, XM Liu

Journal of the Endocrine Society (Oxford Academic) China, 28 February 2023

Oncology

Key words: mitochondrial fusion, testosterone, granulosa cells, steroidogenic acute regulatory protein, sex hormones, polycystic ovary syndrome

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

253
Electrical Sympathetic Neuromodulation Protects Bone Marrow Niche and Drives Hematopoietic Regeneration during Chemotherapy

YT Hsu, LH Chen, YH Liu, SK Chu, TY Chen, KJ Tsai, MR Shen, W Liu

Small Methods (Wiley) Taiwan, USA, 26 February 2023

Neuroscience

Key words: bone marrow niche, chemotherapy-induced nerve damage, electrical neuromodulation, hematopoiesis

Organism: Rat

Tissue: Bone

254
Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo

P Strasser, B Montsch, S Weiss, H Sami, C Kugler, S Hager, H Schueffl, R Mader, O Brüggemann, CR Kowol, M Ogris, P Heffeter, I Teasdale

Small (Wiley) Austria, 26 February 2023

Nanomedicine

Key words: biodistribution, bottlebrush polymers, nanomedicine, pharmacokinetics, polyglutamate, polymer therapeutics, polyphosphazenes

Organism: Mouse

Tissue: Bone, Kidney, Xenograft Tumor

Pathological State: Cancer

255
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke

H Zheng, X Guo, S Kang, Z Li, T Tian, J Li, F Wang, P Yu, S Chang, YZ Chang

Cell Death & Disease (Nature) China, 25 February 2023

Neuroscience

Key words: Stroke

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

256
UHRF1/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer

S Lin, H Xu, L Qin, M Pang, Z Wang, M Gu, L Zhang, C Zhao, X Hao, Z Zhang, W Ding, J Ren, J Huang

Acta Pharmaceutica Sinica B (Elsevier) China, 24 February 2023

Oncology

Key words: Lung cancer, Intratumor heterogeneity, Splice variants, Intragenic CpG methylation, Protease serine 3, Myeloid zinc finger 1, UHRF1/DNMT1, 5-Aza-CdR

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

257
Transgenic HPV11-E2 protein modulates URR activity in vivo

S Wang, V Gramm, E Laport, T Holland-Letz, A Alonso, J Schenkel

Transgenic Research (Springer) Germany, 24 February 2023

Virology

Key words: HPV-E2, Human papillomavirus type 11, Reporter gene, Transgenic mouse model, Upstream regulatory region URR

Organism: Mouse

Tissue: Skin

258
Immune Microenvironment in Sporadic Early-Onset versus Average-Onset Colorectal Cancer

F Andric, A Al-Fairouzi, Y Wettergren, L Szeponik, E Bexe-Lindskog, JC Cusack Jr, G Tumusiime, M Quiding-Järbrink, D Ljungman

Cancers (MDPI) Sweden, USA, Uganda, 24 February 2023

Oncology

Key words: early-onset colorectal cancer, tumor microenvironment, tumor-infiltrating lymphocytes, gene expression, immunofluorescence

Organism: Human

Tissue: Colon

Pathological State: Cancer

259
Poly (I: C) Exacerbates Airway Goblet Cell Hyperplasia and Lung Inflammation in HDM-Exposed Balb/C Mice by YAP/FOXM1 Pathway

ML Bu, MH Li, M Feng, JR Wang, L Sun

International Archives of Allergy and Immunology (Karger) China, 23 February 2023

Immunology

Key words: YAP, Poly(I:C), Asthma, Airway inflammation, Goblet cell hyperplasia

260
Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging

VA Onofrei, CL Zamfir, E Anisie, A Ceasovschih, M Constantin, F Mitu, CA Adam, ED Grigorescu, AD Petroaie, D Timofte

Medicina (MDPI) Romania, 22 February 2023

Cardiology

Key words: arterial stiffness, cardiovascular risk, morbid obesity, pulse wave analysis, adiponectin, chemerin, adipocyte

Organism: Human

Tissue: Adipose Tissue

Pathological State: Obesity

261
Oolong tea of different years protects high-fat diet-fed mice against obesity by regulating lipid metabolism and modulating gut microbiota

WW Fang, KF Wang, F Zhou, J Ou-yang, ZY Zhang, CW Liu, HZ Zeng, JA Huang, ZH Liu

Food & Function (Royal Society of Chemistry) China, 21 February 2023

Endocrinology

262
SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway

W Zhang, X Li, M Jiang, C Ji, G Chen, Q Zhang, P Liu, R Zhang, X Ren, W Yu, J Yu

Journal of Leukocyte Biology (Oxford Academic) China, 20 February 2023

Oncology

Key words: breast cancer, early-stage myeloid-derived suppressor cells, Wnt/mTOR pathway, autophagy

Organism: Human

Tissue: Breast

Pathological State: Cancer

263
MRI histogram analysis of tumor-infiltrating CD8+ T cell levels in patients with glioblastoma

C Xue, Q Zhou, P Zhang, B Zhang, Q Sun, S Li, J Deng, X Liu, J Zhou

NeuroImage: Clinical (Elsevier) China, 18 February 2023

Oncology

Key words: Glioblastoma, Magnetic resonance imaging, Histogram analysis, CD8+ T cells, Tumor microenvironment

Organism: Human

Tissue: Brain

Pathological State: Cancer

264
Intestinal Farnesoid X Receptor Modulates Duodenal Surface Area but Does Not Control Glucose Absorption in Mice

J Yang, TH van Dijk, M Koehorst, R Havinga, JF de Boer, F Kuipers

International Journal of Molecular Sciences (MDPI) The Netherlands, 18 February 2023

Gastroenterology

Key words: glucose absorption, intestinal FXR, duodenum, GS3972

Organism: Mouse

Tissue: Small Intestine

265
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease

S Yan, X Zheng, Y Lin, C Li, Z Liu, J Li, Z Tu, Y Zhao, C Huang, Y Chen, J Li, X Song, B Han, W Wang, W Liang, L Lai, XJ Li, S Li

Nature Biomedical Engineering (Nature) China, 16 February 2023

Neuroscience

Key words: Huntington's disease, Preclinical research

Organism: Pig

Tissue: Brain

Pathological State: Huntington's Disease

266
Bavachinin Protects the Liver in NAFLD by Promoting Regeneration via Targeting PCNA

X Dong, S Lu, Y Tian, H Ma, Y Wang, X Zhang, G Sun, Y Luo, X Sun

Journal of Advanced Research (Elsevier) China, 16 February 2023

Hepathology

Key words: Bavachinin, CC-ABPP, NAFLD, Liver regeneration, PCNA

Organism: Hamster

Tissue: Liver

267
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer

M Zagorulya, L Yim, DM Morgan, A Edwards, E Torres-Mejia, N Momin, CV McCreery, IL Zamora, BL Horton, JG Fox, KD Wittrup, JC Love, S Spranger

Immunity (Cell Press) USA, 14 February 2023

Immunology, Oncology

Key words: regulatory T cells, cross-presenting dendritic cells, cytotoxic T cells, T cell dysfunction, T cell priming, anti-tumor immunity, non-small cell lung cancer, interferon-gamma, Th1-like effector regulatory T cells, tissue-specific immunity

Tissue: Lymphoid Tissue

Pathological State: Cancer

268
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation

T Krausgruber, A Redl, D Barreca, K Doberer, D Romanovskaia, L Dobnikar, M Guarini, L Unterluggauer, L Kleissl, D Atzmuller, C Mayerhofer, A Kopf, S Saluzzo, CX Lim, P Rexie, T Weichhart, C Bock, G Stary

Immunity (Cell Press) Austria, 14 February 2023

Immunology

Organism: Human

Tissue: Skin

Pathological State: Lesional Sarcoidosis

269
Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-specific Pathways

Y Li, P Liu, Y Zhou, H Maekawa, JB Silva, MJ Ansari, K Boubes, Y Alia, DK Deb, BR Thomson, J Jin, SE Quaggin

Journal of The American Society of Nephrology (Wolters Kluwer) USA, 14 February 2023

Nephrology

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Ischemia

270
Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis

T Qiao, W Yang, X He, P Song, X Chen, R Liu, J Xiao, X Yang, M Li, Y Gao, G Chen, Y Lu, J Zhang, J Leng, H Ren

Cell Death & Disease (Nature) China, 13 February 2023

Oncology

Key words: Cancer microenvironment, Kupffer cells, Metastasis, Tumour angiogenesis

Organism: Mouse

Tissue: Liver, Allograft Tumor

Pathological State: Cancer

271
Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1

X Liu, Y Jiang, H Zhou, X Zhao, M Li, Z Bao, Z Wang, C Zhang, Z Xie, J Zhao, Z Dong, K Liu, Z Guo

Cell Death & Disease (Nature) China, 13 February 2023

Oncology

Key words: Cancer prevention, Proteomics, Target identification

Organism: Mouse

Tissue: Xenograft Tumor, Skin

Pathological State: Cancer

272
CD39-Expressing CD8+ T Cells as a New Molecular Marker for Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma

M Liu, Y Zhao, Z Xiao, R Zhou, X Chen, S Cui, S Cao, X Huang, T Chen, X Huo, G Zhang, Z Tian, N Wang

Cancers (MDPI) China, 13 February 2023

Oncology

Key words: esophageal squamous cell carcinoma, CD39+CD8+ T cells, diagnosis, prognosis, nomogram, tumor microenvironment

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

273
Tissue‐resident CXCR4+ macrophage as a poor prognosis signature promotes pancreatic ductal adenocarcinoma progression

Z Liao, L Ye, T Li, X Jin, X Lin, Q Fei, H Zhang, S Shi, X Yu, K Jin, W Wu

International Journal of Cancer (Wiley) China, 09 February 2023

Oncology

Key words: CXCR4, pancreatic ductal adenocarcinoma, prognosis, SPARC, tissue-resident macrophage

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

274
Skin infiltrate composition as a telling measure of responses to checkpoint inhibitors.

C Kosche, D Jaishankar, C Cosgrove, P Ramesh, S Hong, L Li, RS Shivde, D Bhuva, BE Perez White, SS Munir, H Zhang, KQ Lu, JN Choi, IC Le Poole

JID Innovations (Elsevier) USA, 09 February 2023

Oncology

Organism: Human

Tissue: Skin

275
Prevalence of tumour-infiltrating CD103+ cells identifies therapeutic-sensitive prostate cancer with poor clinical outcome

Q Zhou, Y Ou, X Dai, X Chen, S Wu, W Chen, M Hu, C Yang, L Zhang, H Jiang

British Journal of Cancer (Nature) China, 09 February 2023

Oncology

Key words: Cancer microenvironment, Immune evasion, Prognostic markers

Organism: Human

Tissue: Prostate

Pathological State: Cancer

276
Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet‐Induced Adiposity

Y Sun, J Zhang, J Hong, Z Zhang, P Lu, A Gao, M Ni, Z Zhang, H Yang, J Shen, J Liu, W Xue, Q Lv, Y Bi, YA Zeng, W Gu, G Ning, W Wang, R Liu, J Wang

Advanced Science (Wiley) China, 08 February 2023

Endocrinology

Key words: obesity, pathogenic gene, RSPO1, thermogenesis, whole-exome sequenc-ing, Wnt signaling

Organism: Mouse

Tissue: Adipose Tissue

277
Artificial Base-Directed In Vivo Assembly of an Albumin–siRNA Complex for Tumor-Targeting Delivery

Y Sun, D Yu, X Geng, D Ding, Y Yang, Z Liu, Z Xiao, R Wang, W Tan

ACS Applied Materials & Interfaces (ACS Publications) China, 07 February 2023

Oncology, Pharmacology

Key words: artificial base, siRNA, albumin, targeted delivery, long circulation, tumor accumulation

Organism: Mouse

Tissue: Heart, Kidney, Liver, Spleen, Lung

278
Empagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis

CC Chung, YK Lin, YC Chen, YH Kao, YH Yeh, NN Trang, YJ Chen

Cardiovascular Diabetology (Springer) Taiwan, Vietnam, 06 February 2023

Cardiology

Key words: Fibroblasts, Fibrosis, Empagliflozin, Sodium-glucose co-transporter 2, Calcium, Sodium-Hydrogen exchanger

Organism: Rat

Tissue: Heart

Pathological State: Atrial fibrosis

279
Synthesis and Anti-Melanoma Activity of L-Cysteine-Coated Iron Oxide Nanoparticles Loaded with Doxorubicin

LI Toderascu, LE Sima, S Orobeti, PE Florian, M Icriverzi, VA Maraloiu, C Comanescu, N Iacob, V Kuncser, I Antohe, G Popescu-Pelin, G Stanciu, P Ionita, CN Mihailescu, G Socol

Nanomaterials (MDPI) Romania, 04 February 2023

Nanomedicine

Key words: magnetic nanoparticles, melanoma, L-Cys, Dox, chemotherapeutic

Cell Line: B16F10 melanoma murine cell line, CCD1070SK fibroblast and melanoma A375 human cell lines

280
The Role of Green Tea Catechin Epigallocatechin Gallate (EGCG) and Mammalian Target of Rapamycin (mTOR) Inhibitor PP242 (Torkinib) in the Treatment of Spinal Cord Injury

L Machova Urdzikova, V Cimermanova, K Karova, J Dominguez, K Stepankova, M Petrovicova, K Havelikova, CD Ghandi, M Jhanwar-Uniyal, P Jendelova

Antioxidants (MDPI) Czech Republic, USA, 03 February 2023

Neuroscience

Key words: spinal cord injury, mTOR pathway, EGCG, PP 242, inflammatory response, neuroregeneration, astrogliosis, axonal growth

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

281
Mapping thalamic innervation to individual L2/3 pyramidal neurons and modeling their 'readout'of visual input

A Balcioglu, R Gillani, M Doron, K Burnell, T Ku, A Erisir, K Chung, I Segev, E Nedivi

Nature Neuroscience (Nature) USA, South Korea, Israel, 02 February 2023

Neuroscience

Key words: Sensory processing, Striate cortex

Organism: Mouse

Tissue: Brain

282
PKCδ promotes the invasion and migration of colorectal cancer through c-myc/NDRG1 pathway

H Jia, Y Shao, X Zhou, G Yang, L Huang, B Aikemu, SC Li, CS Ding, XD Fan, HJ Hong, S Zhang, RJ Pan, J Sun

Frontiers in Oncology (Frontiers Media S.A.) China, 02 February 2023

Oncology

Key words: colorectal cancer, protein kinase C δ, N-myc downstream-regulated gene 1, metastasis, epithelial-mesenchymal transition

Organism: Human

Tissue: Colon

Pathological State: Cancer

283
Amentoflavone induces caspase‐dependent/− independent apoptosis and dysregulates cyclin‐dependent kinase‐mediated cell cycle in colorectal cancer in vitro and in vivo

CH Lin, KH Lin, HJ Ku, KC Lee, SS Lin, FT Hsu

Environmental Toxicology (Wiley) Taiwan, 02 February 2023

Oncology

Organism: Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

284
Apolipoprotein E negatively regulates allergic airway inflammation and remodeling in mice with OVA-induced chronic asthma

Y Shen, L Li, W Chen, Q Li, Y Xu, F He, C Wang, Z Tian, Y Chen, Y Yang

International Immunology (Elsevier) China, 01 February 2023

Allergy Research

Key words: ApoE, Airway remodeling, Chronic airway inflammation, Th2 responses

Organism: Mouse

Tissue: Lung

Pathological State: Asthma

285
Overexpression of Both Human Sodium Iodide Symporter (NIS) and BRG1-Bromodomain Synergistically Enhances Radioiodine Sensitivity by Stabilizing p53 through NPM1 Expression

J Na, CH Lee, JK Chung, H Youn

International Journal of Molecular Sciences (MDPI) South Korea, 01 February 2023

Oncology

Key words: sodium iodide symporter, radioiodine therapy, iodine-131, brahma-related gene 1 bromodomain, radiosensitization, thyroid cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

286
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models

M Datta, S Chatterjee, EM Perez, S Gritsch, S Roberge, M Duquette, IX Chen, K Naxerova, A S Kumar, M Ghosh, KE Emblem, MR Ng, WW Ho, P Kumar, S Krishnan, X Dong, MC Speranza, MR Neagu, JB Iorgulescu, RY Huang, G Youssef, DA Reardon, AH Sharpe, GJ Freeman, ML Suvà, L Xu, RK Jain

PNAS (Proceedings of the National Academy of Sciences of the United States of America) USA, Poland, Norway, 01 February 2023

Immunology, Oncology

Key words: immune checkpoint blockers, glioblastoma, immune-related adverse events, tumor microenvironment , biomarkers

Organism: Mouse

Tissue: Brain, Xenograft Tumor

Pathological State: Cancer

287
Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression

C Liu, M Zhang, X Yan, Y Ni, Y Gong, C Wang, X Zhang, L Wan, H Yang, C Ge, Y Li, W Zou, R Huang, X Li, B Sun, B Liu, J Yue, J Yu

Science Advances (Science) China, 27 January 2023

Oncology

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

288
Development and Characterization of a Highly Selective Turn-On Fluorescent Ligand for β3-Adrenergic Receptor

W Li, Z Ma, L Du, M Li

Analytical Chemistry (ACS Publications) China, 26 January 2023

Biological Methods

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

289
Transcriptional Regulation of Math1 by Aryl Hydrocarbon Receptor: Effect on Math1+ Progenitor Cells in Mouse Small Intestine

Y Yagishita, T Joshi, TW Kensler, N Wakabayashi

Molecular and Cellular Biology (Taylor & Francis) USA, 26 January 2023

Gastroenterology

Key words: AhR, Math1, intestinal organoids, Math1+ progenitor cells, goblet cells

290
Lingguizhugan decoction improves non-alcoholic steatohepatitis partially by modulating gut microbiota and correlated metabolites

M Zhu, X Wang, K Wang, Z Zhao, Y Dang, G Ji, F Li, W Zhou

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) China, 26 January 2023

Hepathology

Key words: Lingguizhugan decoction, NASH, MCD diet, gut microbiota, metabolomics

Organism: Rat

Tissue: Liver

Pathological State: Non-alcoholic steatohepatitis

291
New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma

IV Militaru, AA Rus, CVA Munteanu, G Manica, SM Petrescu

Frontiers in Oncology (Frontiers Media S.A.) Romania, 26 January 2023

Oncology

Key words: melanoma biomarkers, amelanotic melanoma, mass spectrometry, proteomics, melanoma diagnostic, melanoma prognostic

Pathological State: Cancer

Cell Line: A375, SKMEL28, SKMEL23 and MNT1 cells

292
PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon

X Yang, T Yabe-Wada, J Han, F Saito, C Ogasawara, S Yamada, N Onai

International Immunology (Oxford Academic) Japan, China, 25 January 2023

Immunology

Key words: PCBP1, macrophage, CCL2, IBD, proinflammatory cytokine

293
Glycoside combinations of Buyang Huanwu decoction ameliorate atherosclerosis via STAT3, HIF-1, and VEGF

F Yan, H Ding, Z Sun, J Liu, J Li, D Zhou, W Zhang

Naunyn-Schmiedeberg's Archives of Pharmacology (Springer) China, 24 January 2023

Cardiology, Pharmacology

Key words: Network pharmacology, Buyang Huanwu decoction, Glycoside combination, Atherosclerosis, Angiogenesis

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

294
LRRC3B and its promoter hypomethylation status predicts response to anti-PD-1 based immunotherapy

L Luo, S Fu, W Du, L He, X Zhang, Y Wang, y Zhou, S Hong

Frontiers in Immunology (Frontiers Media S.A.) China, 24 January 2023

Oncology, Immunology

Key words: pan-cancer, tumor immune microenvironment, immunotherapy, leucine rich repeat containing 3B, DNA methylation

Organism: Human

Tissue: Lung

Pathological State: Cancer

295
Intravenous aav9 administration results in safe and widespread distribution of transgene in the brain of mini-pig

Y Lin, C Li, W Wang, J Li, C Huang, X Zheng, Z Liu, X Song, Y Chen, J Gao, J Wu, J Wu, Z Tu, L Lai, XJ Li, S Li, S Yan

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 24 January 2023

Neuroscience

Key words: AAV9, CNS, large animal, pig, neurodegeneration

Organism: Pig

Tissue: Brain

296
Melatonin improves muscle injury and differentiation by increasing Pax7 expression

CM Su, CH Tsai, HT Chen, YS Wu, JW Chang, SF Yang, CH Tang

International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan, 22 January 2023

Pharmacology

Key words: melatonin, Pax7, muscle injury, differentiation, miR-3475-3p

Organism: Mouse

Tissue: Muscle

Pathological State: Muscle injury

297
Modulatory Effects of Heat-Inactivated Streptococcus Thermophilus Strain 7 on the Inflammatory Response: A Study on an Animal Model with TLR3-Induced Intestinal Injury

GA Lee, YW Chang, WL Lin, YCSH Yang, WJ Chen, FH Huang, YR Liu

Microorganisms (MDPI) Taiwan, Malaysia, 20 January 2023

Microbiology, Immunology

Key words: Streptococcus thermophilus, microbiota, poly I:C, inflammation, IL-15

Organism: Mouse

Tissue: Small Intestine

Pathological State: TLR3-Induced Intestinal Injury

298
Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?

D Schmidbauer, S Fink, F Rousset, H Löwenheim, P Senn, R Glueckert

International Journal of Molecular Sciences (MDPI) Austria, Germany, Switzerland, 19 January 2023

Neuroscience

Key words: nerve regeneration, cochlear implant, spiral ganglion, neurotrophin treatment, electrical stimulation

Cell Line: Murine spiral ganglion neurons

299
Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington's disease

A Matsushima, SS Pineda, JR Crittenden, H Lee, K Galani, J Mantero, G Tombaugh, M Kellis, M Heiman, AM Graybiel

Nature Communications (Nature) USA, 17 January 2023

Neuroscience

Key words: Huntington's disease, Molecular neuroscience, Transcriptomics

Organism: Mouse

Tissue: Brain

Pathological State: Huntington's disease

300
Engineering orthotopic tumor spheroids with organ-specific vasculatures for local chemoembolization evaluation

Y Gao, J Xiao, Z Chen, Y Ma, X Liu, D Yang, H Liang Leo, H Yu, J Kong, Q Guo

Biomaterials Science (Royal Society of Chemistry) China, Singapore, 17 January 2023

Biological Methods

301
Prognostic role of the innate immune signature CD163 and “eat me” signal calreticulin in clear cell renal cell carcinoma

T Anno, N Tanaka, K Takamatsu, K Hakozaki, R Kufukihara, Y Baba, T Takeda, K Matsumoto, S Morita, T Kosaka, S Mikami, H Nishihara, R Mizuno, M Oya

Cancer Immunology, Immunotherpay (Springer) Japan, 17 January 2023

Oncology

Key words: Renal cell carcinoma, Kidney cancer, Innate immunity, CD163, Tumor-associated macrophage, Calreticulin, Eat me signal, Survival

Organism: Human

Tissue: Kidney

Pathological State: Cancer

302
Environmental endocrine disruptor Bisphenol A induces metabolic derailment and obesity via upregulating IL-17A in adipocytes

X Hong, Y Zhou, Z Zhu, Y Li, Z Li, Y Zhang, XX Hu, F Zhu, Y Wang, M Fang, Y Huang, T Shen

Environment International (Elsevier) China, 16 January 2023

Endocrinology

Key words: Obesity, Bisphenol A, Inflammation, Insulin resistance, IL-17A

Organism: Mouse

Tissue: Adipose Tissue

Pathological State: Obesity

303
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

D Savic, TB Steinbichler, J Ingruber, G Negro, B Aschenbrenner, H Riechelmann, U Ganswindt, S Skvortsov, J Dudas, II Skvortsova

Cells (MDPI) Austria, 16 January 2023

Oncology

Key words: HNSCC, erastin, xCT, ERK signaling

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

304
Daurisoline suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting MEK1/2 kinase

D Wang, W Zhang, X Zhang, M Li, Q Wu, X Li, L Zhao, Q Yuan, Y Yu, J Lu, J Zhao, Z Dong, K Liu, Y Jiang

Molecular Carcinogenesis (Wiley) China, 16 January 2023

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

305
Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia–reperfusion injury

T Mei, J Wu, K Wu, M Zhao, J Luo, X Liu, B Shang, W Xu, Z Yang, Y Lai, C Liu, H Gong, X Gao, Y Zhuo, M Lin, L Zhao

Annals of Translational Medicine (AME Publishing Company) China, 15 January 2023

Ophthalmology

Key words: Lipocalin-2 (LCN2), retinal ischemia-reperfusion injury (RIR injury), ferroptosis, retinal ganglion cell (RGC), visual impairment

Organism: Mouse

Tissue: Eye

Pathological State: Retinal Ischemia

306
BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti‐PD‐1/PD‐L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity

Z Cai, J Chen, Z Yu, H Li, Z Liu, D Deng, J Liu, C Chen, C Zhang, Z Ou, M Chen, J Hu, X Zu

Advanced Science (Wiley) China, 15 January 2023

Oncology, Pharmacology

Organism: Human

Tissue: Bladder

Pathological State: Cancer

307
SN‐38, an active metabolite of irinotecan, enhances anti‐PD1 treatment efficacy in head and neck squamous cell carcinoma

YM Lee, YH Chen, DL Ou, CL Hsu, JH Liu, JY Ko, MCT Hu, CT Tan

The Journal of Pathology (Wiley) Taiwan, USA, 15 January 2023

Oncology

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

308
miR-432 exerts a protective effect against myocardial ischemia/reperfusion injury by activating the β-catenin/HIF-1α pathway and augmenting NRF2-mediated anti-oxidative stress

RY Su, WY Tai, HS Yin, XY Geng

American Journal of Translational Research (e-Century Publishing Corporation) China, 15 January 2023

Cardiology

Key words: apoptosis, microRNA, myocardial ischemia/reperfusion injury, oxidative stress

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Ischemia

309
Production and characterization of cell-penetrating recombinant botulinum neurotoxin type A

X Wei, J Hu, L Jiang, L Li, J Liu

STAR Protocols (Elsevier) China, 13 January 2023

Biological Methods

Key words: Cell culture, Protein Biochemistry, Protein Expression and Purification, Biotechnology and Bioengineering

Cell Line: N2a cells

310
Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice

Q Ma, D Su, J Huo, G Yin, D Dong, K Duan, H Cheng, H Xu, J Ma, D Liu, B Mou, J Peng, L Cheng

Neuroscience Bulletin (Springer) China, 13 January 2023

Neuroscience

Key words: Microglia, Mechanical allodynia, Laterality, Spinal dorsal horn, Aβ, Dynamic allodynia, Punctate allodynia

Organism: Mouse

Tissue: Brain, Spinal Cord

Pathological State: Mechanical Allodynia

311
Theabrownin inhibits obesity and non-alcoholic fatty liver disease in mice via serotonin-related signaling pathways and gut-liver axis

HY Li, SY Huang, DD Zhou, RG Xiong, M Luo, A Saimaiti, MK Han, RY Gan, HL Zhu, HB Li

Journal of Advanced Research (Elsevier) China, 11 January 2023

Hepathology

Key words: non-alcoholic fatty liver disease, anti-obesity, theabrownin, serotonin, gut microbiota

Organism: Mouse

Tissue: Liver

312
The imbalance of NKG2A and NKG2D expression is involved in NK cell immunosuppression and tumor progression of HBV‐HCC patients

L Yu, L Sun, X Liu, X Wang, H Yan, Q Pu, Y Xie, Y Jiang, J Du, Z Yang

Hepatology Research (Wiley) China, 11 January 2023

Oncology

Key words: NK cell, NKG2A, NKG2D, hepatitis B virus-related hepatocellular carcinoma, immunosuppression

Organism: Human

Tissue: Liver

Pathological State: Cancer

313
Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy

R Chi, C Chai, G Liu, H Cao, B Yang

Human Cell (Springer) China, 10 January 2023

Cardiology

Key words: OSAS, CIH, Autophagy, BNIP3, Apoptosis, Cardiac hypertrophy

Organism: Rat

Tissue: Heart

Pathological State: Contractile dysfunction

314
Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

D Liu, C Liang, B Huang, X Zhuang, W Cui, L Yang, Y Yang, Y Zhang, X Fu, X Zhang, L Du, W Gu, X Wang, C Yin, R Chai, B Chu

Advanced Science (Wiley) China, USA, 10 January 2023

Oncology

Key words: 3-HA, 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), 5-HT, ferroptosis, kynureninase (KYNU, monoamine oxidase A (MAOA), tryptophan

Organism: Human

Tissue: Liver, Kidney

Pathological State: Cancer

315
Immune dysregulation in immunoglobulin G4–related disease

T Maehara, R Koga, S Nakamura

Japanese Dental Science Review (Elsevier) Japan, 09 January 2023

Immunology

Key words: Autoimmune, Anti-inflammatory, Single-cell RNA sequencing, IgG4-related disease, Cytotoxic T cells, Salivary gland

316
Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance

F Du, G Yin, L Han, X Liu, D Dong, K Duan, J Huo, Y Sun, L Cheng

Neuroscience Bulletin (Springer) China, 09 January 2023

Neuroscience

Key words: μ-opioid receptor, Morphine, Mechanical allodynia, Punctate allodynia, Dynamic allodynia, OIH, Tolerance, Aβ-fiber

Organism: Mouse

Tissue: Brain, Spinal Cord

Pathological State: Mechanical Allodynia

317
Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive 18F-FDG PET/CT and Serum 1H-NMR Analysis: An Orthotopic Murine Model Study

YH Chung, TH Hung, CF Yu, CK Tsai, CC Weng, F Jhang, FH Chen, G Lin

Metabolites (MDPI) Taiwan, 09 January 2023

Oncology

Key words: lung cancer, 18F-FDG, 1H-NMR, animal study, metastasis

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

318
Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis

BY Ahn, Y Jeong, S Kim, Y Zhang, SW Kim, YE Leem, JS Kang

Experimental & Molecular Medicine (Nature) South Korea, 06 January 2023

Cell Biology

Key words: Calcification, Stress signalling

Organism: Mouse

Tissue: Blood Vessels

319
Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts

YC Huang, MF Hou, YM Tsai, YC Pan, PH Tsai, YS Lin, CY Chang, EM Tsai, YL Hsu

Cellular Oncology (Springer) Taiwan, 06 January 2023

Oncology

Key words: Acetyl-CoA carboxylase α, Breast cancer, Metabolism reprogramming, Pre-metastatic niche, Senescence

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

320
Role of iodine density value on dual-energy CT for detection of high tumor cell proportion region in lung cancer during CT-guided transthoracic biopsy

Y Ma, S Li, G Huang, X Huang, Q Zhou, W Wang, J Wang, F Zhao, Z Li, X Chen, B Zhu, J Zhou

European Journal of Radiology (Elsevier) China, 06 January 2023

Oncology, Radiotherapy

Key words: Dual-layer spectral detector computed tomography, Iodine density, Transthoracic lung biopsy, High tumor cell proportion region

Organism: Human

Tissue: Lung

Pathological State: Cancer

321
PLVAP as an Early Marker of Glomerular Endothelial Damage in Mice with Diabetic Kidney Disease

EE Wolf, A Steglich, F Kessel, H Kröger, J Sradnick, S Reichelt-Wurm, K Eidenschink, MC Banas, E Wolf, R Wanke, F Gembardt, VT Todorov

International Journal of Molecular Sciences (MDPI) Germany, 06 January 2023

Nephrology

Key words: diabetic kidney disease, endothelial damage, PLVAP, diabetic models, glomerular hypertrophy

Organism: Mouse

Tissue: Kidney

Pathological State: Diabetic Kidney Disease

322
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity

Z Fu, S Chen, Y Zhu, D Zhang, P Xie, Q Jiao, J Chi, S Xu, Y Xue, X Lu, X Song, M Christofanilli, WJ Gradishar, K Kalinsky, Y Yin, B Zhang, Y Wan

Science Advances (Science) USA, China, 06 January 2023

Oncology

Organism: Human

Tissue: Breast

Pathological State: Cancer

323
The transcription factor Eomes promotes expression of inhibitory receptors on hepatic CD8+ T cells during HBV persistence

L Yu, Y Guan, L Li, N Lu, C Zhang

The FEBS Journal (Wiley) China, 05 January 2023

Virology, Immunology

Key words: CD8+ T cell exhaustion, chronic HBV persistence, Eomes, inhibitory receptor, transcription factor

Organism: Mouse

Tissue: Liver

Pathological State: Hepatitis B virus Infection

324
Comparing the Therapeutic Mechanism and Immune Response of Human and Mouse Mesenchymal Stem Cells in Immunocompetent Mice With Acute Liver Failure

CH Wang, CY Chen, KH Wang, AP Kao, YJ Chen, PH Lin, M Chen, TY Wu, JJ Cheng, KD Lee, KH Chuang

Stem Cells Translational Medicine (Oxford Academic) Taiwan, 04 January 2023

Immunology, Hepathology

Key words: mesenchymal stem cells, immunomodulatory, IL-6, F4/80, liver regeneration, liver fibrosis

Organism: Mouse

Tissue: Liver

Pathological State: Acute Liver Failure

325
Limonin counteracts obesity by activating thermogenesis in brown and white adipose tissues

M Yan, S Jin, Z Wang, T Xia, Y Liu, Q Chang

Journal of Functional Foods (Elsevier) China, 02 January 2023

Endocrinology

Key words: Limonin, Obesity, Brown adipose tissue, White adipose tissues, Thermogenesis

Organism: Mouse

Tissue: Liver

326
Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma

JL Sieow, HL Penny, SY Gun, LQ Tan, K Duan, JPS Yeong, A Pang, D Lim, HC Toh, TKH Lim, E Engleman, O Rotzschke, LG Ng, J Chen, SM Tan, SC Wong

International Journal of Molecular Sciences (MDPI) Singapore, USA, 01 January 2023

Oncology

Key words: neutrophils, pancreatic cancer, hypoxia-inducible factor 1-alpha

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

327
Nesfatin-1 stimulates CCL2-dependent monocyte migration and M1 macrophage polarization: implications for rheumatoid arthritis therapy

JW Chang, SC Liu, YY Lin, XY He, YS Wu, CM Su, CH Tsai, HT Chen, YC Fong, SL Hu, CC Huang, CH Tang

International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan, 01 January 2023

Rheumatology

Key words: rheumatoid arthritis, nesfatin-1, CCL2, M1 macrophages, synovial fibroblasts

Organism: Human, Mouse

Tissue: Joint Tissue

Pathological State: Rheumatoid Arthritis

328
The TgF344-AD Rat: Behavioral and Proteomic Changes Associated with Aging and Protein Expression in a Transgenic Rat Model of Alzheimer's Disease

B Bac, C Hicheri, C Weiss, A Buell, N Vilcek, C Spaeni, C Geula, JN Savas, JF Disterhoft

Neurobiology of Aging (Elsevier) USA, 30 December 2022

Neuroscience

Key words: watermaze, 6E10, pTau, neuroinflammation, TREM2, Learning Index, proteomics

Organism: Rat

Tissue: Brain

Pathological State: Alzheimer's Disease

329
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Y Zhou, X He, Y Jiang, Z Wang, Y Yu, W Wu, C Zhang, J Li, Y Huo, X Chen, Z Liu, J Zhao, K Liu, Z Dong

Frontiers of Medicine (Springer) China, 29 December 2022

Oncology

Key words: benzydamine, cyclin-dependent kinase 2, patient-derived xenograft, esophageal squamous cell carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

330
The effect of isovitexin on lipopolysaccharide-induced renal injury and inflammation by induction of protective autophagy

CY Tseng, PR Yu, CC Hsu, HH Lin, JH Chen

Food and Chemical Toxicology (Elsevier) Taiwan, 23 December 2022

Nephrology

Key words: Kidney injury, Isovitexin, Lipopolysaccharide, Inflammation, Autophagy

Organism: Mouse

Tissue: Kidney

Pathological State: Lipopolysaccharide-induced kidney injury

331
Myofibroblast stroma differentiation in infiltrative basal cell carcinoma is accompanied by regulatory T‐cells

JM Ressler, N Zila, A Korosec, J Yu, R Silmbrod, V Bachmayr, J Tittes, J Strobl, BM Lichtenberger, C Hoeller, P Petzelbauer

Journal of Cutaneous Pathology (Wiley) Austria, 23 December 2022

Oncology

Key words: Basal cell carcinoma, infiltrative BCC, regulatory T-cells, TGF-β, alpha smooth muscle actin

Organism: Human

Tissue: Skin

Pathological State: Cancer

332
Mitigation of Cellular and Bacterial Adhesion on Laser Modified Poly (2-Methacryloyloxyethyl Phosphorylcholine)/Polydimethylsiloxane Surface

S Nistorescu, M Icriverzi, P Florian, A Bonciu, V Marascu, N Dumitrescu, G Gradisteanu Pircalabioru, L Rusen, A Mocanu, A Roseanu, A Cimpean, F Grama 6, V Dinca, DA Cristian

Nanomaterials (MDPI) Romania, 23 December 2022

Tissue Engineering

Key words: MAPLE, zwitterionic coating, cellular response

Cell Line: Fibroblasts cultured on PDMS scaffolds

333
Biomimetic Prussian blue nanozymes with enhanced bone marrow-targeting for treatment of radiation-induced hematopoietic injury

B Zhang, G Chen, X Wu, Y Li, Y Xiao, J Li, L He, Y Li, S Wang, J Zhao, C Liu, H Zhou, Y Li, X Pei

Biomaterials (Elsevier) China, 21 December 2022

Nanomedicine

Key words: Prussian blue nanozymes, Mesenchymal stem cell membrane, Reactive oxygen species, Radiation-induced hematopoietic injury, Targeting therapy

Organism: Mouse

Tissue: Bone

Pathological State: Radiation-induced hematopoietic injury

334
Avicularin Alleviates Osteoporosis in Ovariectomized Mice by Inhibiting Osteoclastogenesis through NF-κB Pathway Inhibition

Q Zhuang, S Chen, W Zhang, M Gu, L Xiao, Y Li, Y Yang, C Feng, H Li, D Geng, Z Wang

Journal of Agricultural and Food Chemistry (ACS Publications) China, 20 December 2022

Osteology

Key words: osteoclast avicularin bone loss NF-κB

Organism: Mouse

Tissue: Bone

335
R158Q and G212S, novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome

Z Li, H Wu, S Wei, M Liu, Y Shi, M Li, N Wang, L Fang, B Xiang, L Gao, C XU, J Zhao

Frontiers of Medicine (Frontiers Media S.A.) China, 19 December 2022

Endocrinology

Key words: Gitelman syndrome, mouse model, compound heterozygous, hypokalemia, Slc12a3

Organism: Mouse

Tissue: Kidney

Pathological State: Gitelman syndrome

336
A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging

H Zhang, Y Guo, J Jiao, Y Qiu, Y Miao, Y He, Z Li, C Xa, L Li, J Cai, K Xu, X Liu, C Zhang, BH Bay, S Song, Y Yang, M Peng, Y Wang, H Fan

Nature Biomedical Engineering (Nature) China, 19 December 2022

Biological Methods

Key words: Biomedical engineering, Magnetic resonance imaging

Organism: Pig

Tissue: Liver

337
Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

PA Goldsteen, AM Sabogal Guaqueta, PPM Mulder, IST Bos, M Eggens, L Van der Koog, JT Soeiro, AJ Halayko, K Mathwig, LEM Kistemaker, EMJ Verpoorte, AM Dolga, R Gosens

Frontiers in Pharmacology (Frontiers Media S.A.) The Netherlands, 18 December 2022

Neuroscience

Key words: asthma, cholinergic, neuron, organ-on-chip, stem cell

Cell Line: Airway cholinergic neurons

338
Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice

STJ Ang, EM Crombie, H Dong, KT Tan, A Hernando, D Yu, S Adamson, S Kim, DJ Withers, H Huang, SY Tsai

Nature Communications (Nature) Singapore, USA, UK, 17 December 2022

Aging

Key words: Ageing, Muscle stem cells, Skeletal muscle

Organism: Mouse

Tissue: Muscle

339
Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10

J Yang, C Hou, H Wang, EA Perez, HC Do-Umehara, H Dong, V Arunagiri, F Tong, M Van Scoyk, M Cho, X Liu, X Ge, RA Winn, KM Ridge, X Wang, NS Chandel, J Liu

Cancer Letters (Elsevier) USA, 17 December 2022

Oncology

Key words: KRAS, Non-small cell lung cancer, Pcdh10, Gene regulation, Miz1

Organism: Mouse

Tissue: Lung

340
FOXM1 increases hTERT protein stability and indicates poor prognosis in gastric cancer

Q Tang, C Liu, S Zhang, L He, Y Liu, J Wang, X Zhao, X Li

Neoplasia (Elsevier) China, 16 December 2022

Oncology

Key words: Gastric cancer, FOXM1, hTERT, ubiquitination, Wnt/β-catenin

Organism: Human

Tissue: Stomach

Pathological State: Cancer

341
Distribution and Toxicity of Submicron Plastic Particles in Mice

TY Tsou, SH Lee, TH Kuo, CC Chien, HC Chen, TJ Cheng

Environmental Toxicology and Pharmacology (Elsevier) Taiwan, 15 December 2022

Toxicology

Key words: Submicron microplastics, Oral gavage, Number concentration, Flow cytometry, Oxidative stress, Inflammation

Organism: Mouse

Tissue: Lung

342
Synergistic cytotoxicity of perifosine and ABT‐737 to colon cancer cells

B Adamová, K Říhová, J Pokludová, P Beneš, J Šmarda, J Navrátilová

Journal of Cellular and Molecular Medicine (Wiley) Czech Republic, 15 December 2022

Oncology

Tissue: Spheroid

Cell Line: HT-29 and HCT-116 human adenocarcinoma cells

343
Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions

M Salzmann, H Platzer, M Mussbacher, M Derler, M Lenz, P Haider, M Brekalo, JB Kral-Pointner, S Kastl, WS Speidl, KT Preissner, U Schubert, M Bischoff, J Wojta, PJ Hohensinner

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Austria, Germany, 10 December 2022

Immunology, Microbiology

Key words: Atherosclerosis, ICAM-1, Extracellular adherence protein, Neutrophils, NET

Organism: Mouse

Tissue: Heart

Pathological State: Staphylococcus aureus Infection

344
Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells

J Chen, J Liu, Z Chen, D Feng, C Zhu, J Fan, S Zhang, X Zhang, J Xu

Virologica Sinica (Elsevier) China, 10 December 2022

Virology

Key words: Myosin IIA (MYH9), Influenza A virus (IAV), vRNP activity, Virus-host interactions, Virus entry

Cell Line: MDCK cells

345
A Proof-of-Concept Preclinical Study Using a Novel Thermal Insulation Device in a Porcine Kidney Auto-Transplantation Model

L Ernst, Z Czigany, P Paschenda, M Schulz, L Breuer, J Kunczik, M Czapli, W Liu, D Jiang, U Klinge, S Djudjaj, P Boor, G Lurje, E Kobayashi, RH Tolba

International Journal of Molecular Sciences (MDPI) Germany, Japan, 09 December 2022

Transplantation Medicine

Key words: kidney transplantation, organ insulation, ischemic reperfusion injury

Organism: Pig

Tissue: Kidney

346
The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer's disease mouse model

CF de Veij Mestdagh, F Koopmans, JC Breiter, JA Timmerman, PC Vogelaar, G Krenning, HD Mansvelder, AB Smit, RH Henning, RE van Kesteren

Alzheimer's Research & Therapy (Springer) The Netherlands, 09 December 2022

Neuroscience

Key words: Alzheimer's disease, APP/PS1 mice, Hibernation-derived compound, SUL-138, Chromanols, Long-term potentiation, Hippocampus-dependent contextual fear memory, Amyloid-beta plaques, Mass-spectrometry, Mitochondria, Fatty acid metabolism

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

347
Angiotensin-converting enzyme 2 in human plasma and lung tissue

J Xie, QF Huang, Z Zhang, Y Dong, H Xu, Y Cao, X Wang, JG Wang

Blood Pressure (Taylor & Francis) China, 09 December 2022

Cardiology

Key words: ACE2, plasma, lung, tissue, hypertension

348
Fumarate hydratase inhibits non‑small cell lung cancer metastasis via inactivation of AMPK and upregulation of DAB2

A Vadhan, YF Yang, YM Wang, PY Chen, SC Tzou, KH Cheng, SCS Hu, TL Cheng, YY Wang, SSF Yuan

Oncology Letters (Spandidos Publications) Taiwan, 09 December 2022

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

349
Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer

K Imamura, Y Tomita, R Sato, T Ikeda, S Iyama, T Jodai, M Takahashi, A Takaki, K Akaike, S Hamada, S Sakata, K Saruwatari, S Saeki, K Ikeda, M Suzuki, T Sakagami

International Journal of Molecular Sciences (MDPI) Japan, USA, 08 December 2022

Oncology

Key words: drebrins, lymphocytes, tumor-infiltrating, lung neoplasms, tumor microenvironment, prognosis

Organism: Human

Tissue: Lung

Pathological State: Cancer

350
Effects of a Phytogenic Supplement Containing Olive By-Product and Green Tea Extracts on Growth Performance, Lipid Metabolism, and Hepatic Antioxidant Capacity in Largemouth Bass (Micropterus salmoides) Fed a High Soybean Meal Diet

J Liu, M Xue, S Morais, M He, H Wang, J Wang, JJ Pastor, RA Gonçalves, X Liang

Antioxidants (MDPI) China, Spain, 07 December 2022

Zoology

Key words: largemouth bass, soybean meal, phytogenic feed additive, antioxidant capacity, lipid metabolism

Organism: Bass Fish

Tissue: Liver

351
Hybrid Transcytosis Nanopomegranates for Sensitizing Breast Cancer Radiotherapy in Deep Tumor Tissue

L Wang, L Xiao, Z Zhao, K Zhong, W Zhu, H Liu, X Li

Nano Research (Scipen) China, 07 December 2022

Oncology

Key words: Breast cancer, transcytosis, hybrid nanopomegranate, hypoxia alleviation, radiosensitization

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

352
HMGB1 Promotes In Vitro and In Vivo Skeletal Muscle Atrophy through an IL-18-Dependent Mechanism

TL Ho, CH Tang, SLY Chang, CH Tsai, HT Chen, CM Su

Cells (MDPI) Taiwan, 06 December 2022

Pharmacology

Key words: HMGB1, IL-18, inflammation, myogenesis, skeletal muscle atrophy

Organism: Mouse

Tissue: Muscle

353
Role of Artificial Intelligence in Cancer Diagnosis and Drug Development

S Srivastava, D Paliwal

Combinatorial Chemistry & High Throughput Screening (Ingenta conect) , 02 December 2022

Oncology

Key words: Cancer, artificial intelligence, computational approach, deep learning, drug development, machine learning

354
Sex-based difference in response to recombinant human bone morphogenetic protein-2 in a rat posterolateral fusion model

JP Foley, EJ Fred, S Minardi, JT Yamaguchi, AC Greene, AA Furman, JG Lyons, JT Paul, TS Nandurkar, KR Blank, RM Havey, M Muriuki, AG Patwardhan, WK Hsu, SR Stock, EL Hsu

Spine (Ingenta conect) USA, 01 December 2022

Key words: BMP, BMP-2, bone, healing, regeneration, rhBMP-2, sex, sex-dependent differences, spinal fusion, spine

355
Tactile cues are important to environmental novelty during repeated open field tests

W Chen, Z Wang, C Ma, X Ma, W Meng, F Yin, Y Yang

Behavioural Processes (Elsevier) China, 30 November 2022

Zoology

Key words: Anxiety, CA1, Environment, Open field test, Repeated testing, Tactile

Organism: Mouse

Tissue: Brain

356
Xenobiotic-induced ribosomal stress compromises dysbiotic gut barrier aging: A one health perspective

J Sun, J Kim, H Jeong, D Kwon, Y Moon

Redox Biology (Elsevier) South Korea, 30 November 2022

Toxicology

Key words: Gut aging, Ribosomal stress, Deoxynivalenol, Gut barrier, Microbiota

Organism: Mouse

Tissue: Small Intestine

357
MiR-140 is involved in T-2 toxin-induced matrix degradation of articular cartilage

Y Shi, X Shao, M Sun, J Ma, B Li, N Zou, F Li

Toxicon (Elsevier) China, 30 November 2022

Toxicology

Key words: miR-140, T-2 toxin, KBD, Articular cartilage, Extracellular matrix

Organism: Mouse

Tissue: Joint Tissue

358
Blockade of c-Met-Mediated Signaling Pathways by E7050 Suppresses Growth and Promotes Apoptosis in Multidrug-Resistant Human Uterine Sarcoma Cells

TT Huang, CM Chen, YW Lan, SS Lin, KB Choo, KY Chong

International Journal of Molecular Sciences (MDPI) Taiwan, USA, Malaysia, 28 November 2022

Pharmacology, Oncology

Key words: E7050, multidrug-resistant uterine sarcoma, apoptosis, cell cycle arrest, c-Met

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

359
The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice

ZD Li, H Li, S Kang, YG Cui, H Zheng, P Wang, K Han, P Yu, YZ Chang

Cell Death & Disease (Nature) China, 28 November 2022

Neuroscience

Key words: Alzheimer's disease, Cognitive ageing

Organism: Mouse

Tissue: Brain

360
Aspirin curcumin ester loaded biomimetic nanodrug improves cognitive deficits in a mouse model of Alzheimer's disease by regulating M1/M2 microglial polarization

Z Li, Z Song, C He, J Fan, W Yu, M Yang, P Li, R Luo, J Zhou, S Xu, B Liu, S Cheng

Materials Today Advances (Elsevier) China, 26 November 2022

Nanomedicine

Key words: Alzheimer's disease, Microglia, Neuroinflammation, Nanoparticle, APP/PS1

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

361
3, 3′-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy

H Tang, K Qin, A Wang, S Li, S Fang, W Gao, M Lu, W Huang, H Zhang, Z Yin

Frontiers in Pharmacology (Frontiers Media S.A.) China, 25 November 2022

Osteology

Key words: 3, 3′-diindolylmethane, osteoarthritis, apoptosis, autophagy, chondrocyte

Organism: Human

Cell Line: Chondrocytes

362
Co-assembled Nanocarriers of De Novo Thiol-Activated Hydrogen Sulfide Donors with an RGDFF Pentapeptide for Targeted Therapy of Non-Small-Cell Lung Cancer

H Chen, X Guan, Q Liu, L Yang, J Guo, F Gao, Y Qi, X Wu, F Zhang, X Tian

ACS Applied Materials & Interfaces (ACS Publications) China, 22 November 2022

Oncology, Nanomedicine

Key words: thiol-activated hydrogen sulfide donors, targeted pentapeptide, coassembled nanocarrier, non-small cell lung cancer, combined radiotherapy

Organism: Mouse

Tissue: Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

363
Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression

D Yang, H Liu, Y Cai, K Lu, X Zhong, S Xing, W Song, Y Zhang, L Ye, X Zhu, T Wang, P Zhang, ST Li, J Feng, W Jia, H Zhang, ST Li, J Feng, W Jia, H Zhang, P Gao

Cell Reports (Cell Press) China, 22 November 2022

Oncology

Key words: branch-chain amino acid, glutamine-depravation, O-GlcNAcylation, HCC progression

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

364
Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling

HC Wang, LY Haung, CJ Wang, YJ Chao, YC Hou, CJ Yen, YS Shan

Journal of Biomedical Science (BMC) Taiwan, 21 November 2022

Oncology

Key words: Hepatocellular carcinoma, Sorafenib resistance, Tumor-associated macrophage, CXCR2, CXCL1, CXCL2

Organism: Human

Tissue: Liver

Pathological State: Cancer

365
Overcoming oxygen heterogeneity of tumor microenvironments to boost cancer immunotherapy by oxygen-switchable ROS/RNS nanogenerators

W Jiang, Z Shen, Z Guo, Q Wang, Q Li, J Hu, Y Wang

Nano Today (Elsevier) China, 21 November 2022

Oncology

Key words: Oxygen-switchable ROS/RNS-releasing polymers, Oxygen heterogeneity, Immunogenic cell death, Cancer immunotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

366
Over-expression of CRTH2 indicates eosinophilic inflammation and poor prognosis in recurrent nasal polyps

W Chen, S He, X Xie, X Yang, C Duan, P Ye, X Li, MG Lawrence, L Borish, X Feng

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 18 November 2022

Pathology

Key words: chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2), chronic rhinosinusitis with nasal polyps, eosinophils, prognosis, recurrent nasal polyp.

Organism: Human

Tissue: Mucosa

Pathological State: Nasal Polyps

367
EBV persistence in gastric cancer cases conventionally classified as EBER-ISH negative

MC Siciliano, S Tornambè, G Cevenini, E Sorrentino, M Granai, G Giovannoni, D Marelli, I Biviano, F Roviello, H Yoshiyama, L Leoncini, S Lazzi, L Mundo

Infectious Agents and Cancer (BMC) Italy, Germany, Japan, Ireland, 17 November 2022

Virology, Oncology

Key words: Gastric adenocarcinoma, Gastric cancer with lymphoid stroma, Epstein Barr Virus, Hit and run mechanism

Organism: Human

Tissue: Stomach

Pathological State: Cancer

368
Formation of the glomerular microvasculature is regulated by VEGFR-3

MD Donnan, DK Deb, T Onay, R Paz Scott, E Ni, Y Zhou, SE Quaggin

American Journal of Physiology (American Physiological Society) USA, 17 November 2022

Physiology

Key words: development, glomerulus, kidney, vascular endothelial growth factor receptor 3, vasculature

Organism: Mouse

Tissue: Kidney

369
Targeting VEGF-A/VEGFR2 Y949 Signaling-Mediated Vascular Permeability Alleviates Hypoxic Pulmonary Hypertension

W Zhou, K Liu, L Zeng, J He, X Gao, X Gu, X Chen, JJ Li, M Wang, D Wu, Z Cai, L Claesson-Welsh, R Ju, J Wang, F Zhang, Y Chen

Circulation (AHA Journals) China, Sweden, 17 November 2022

Cardiology

Key words: single-cell RNA sequencing, smooth muscle, Src family kinase, vascular permeability, hypoxic pulmonary hypertension, VEGF-A, macrophage, VEGFR2 Y949

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Hypertension

370
Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

EM Crombie, S Kim, S Adamson, H Dong, TC Lu, Y Wu, Y Wu, Y Levy, N Stimple, WMR Lam, HWD Hey, DJ Withers, AL Hsu, BH Bay, J Ochala, SY Tsai

Journal of Cachexia, Sarcopenia and Muscle (Wiley) Singapore, USA, Taiwan, UK, Denmark, 17 November 2022

Rheumatology

Organism: Mouse

Tissue: Muscle

371
Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60

Q Guo, M Yin, J Fan, Y Yang, T Liu, H Qian, X Dai, X Wang

Materials & Design (Elsevier) China, 17 November 2022

Nanomedicine

Key words: Glioblastoma, Photothermal therapy, Chemodynamic therapy, Peroxidase-mimicking, HSP60

Organism: Human

Tissue: Brain

Pathological State: Cancer

372
Cbln1 regulates axon growth and guidance in multiple neural regions

P Han, Y She, Z Yang, M Zhuang, Q Wang, X Luo, C Yin, J Zhu, SR Jaffrey, SJ Ji

PLoS Biology (Plos) USA, China, 17 November 2022

Neuroscience

Key words: Axons, Spinal cord, Neurons, Axon guidance, Chemoattractant axon guidance, Retinal ganglion cells, Immunostaining, In situ hybridization

Organism: Mouse

Tissue: Spinal Cord

373
Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer

WJ Cheng, SY Lin, KH Chuang, M Chen, HO Ho, LC Chen, CM Hsieh, MT Sheu

International Journal of Nanomedicine (Taylor & Francis) Taiwan, 16 November 2022

Nanomedicine, Oncology

Key words: docetaxel, pictilisib, nanocarriers, bispecific antibodies, dual epitopes, HER2-positive breast cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

374
Porous scaffold for mesenchymal cell encapsulation and exosome-based therapy of ischemic diseases

A Czosseck, MM Chen, H Nguyen, A Meeson, CC Hsu, CC Chen, TA George, SC Ruan, YY Cheng, PJ Lin, PCH Hsieh, DJ Lundy

Journal of Controlled Release (Elsevier) Taiwan, UK, 14 November 2022

Cardiology, Nanomedicine

Key words: Myocardial infarction, Limb ischemia, Extracellular vesicle, Cell encapsulation, Cell therapy, ExosomeIschemic disease, Cardiac patch

375
Hypothermia evoked by stimulation of medial preoptic nucleus protects the brain in a mouse model of ischaemia

S Zhang, X Zhang, H Zhong, X Li, Y Wu, J Ju, B Liu, Z Zhang, H Yan, Y Wang, K Song, ST Hou

Nature Communications (Nature) China, 12 November 2022

Neuroscience

Key words: Mouse, Stroke

Organism: Mouse

Tissue: Brain

376
Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma

B Yan, L Liu, L Zhao, U Hinz, Y Luo, X An, J Gladkich, C de la Torre, Z Huang, D Schrapel, W Gross, F Fortunato, M Schaefer, MM Gaida, I Herr

Matrix Biology (Elsevier) Germany, 11 November 2022

Oncology, Endocrinology

Key words: Pancreatic cancer, Tumor microenvironment, Pancreatic stellate cells, Collagen type VIII alpha 1 chain, Gemcitabine

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

377
Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice

F Zhang, H Zhen, H Cheng, F Hu, Y Jia, B Huang, M Jiang

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 10 November 2022

Hepathology

Key words: DEHP, liver injury, ferroptosis, endocrine disrupting chemical, pregnancy

Organism: Mouse

Tissue: Liver

378
Response of cadmium adsorption to three-year different agronomic managements in tropical soil: The role of P fractions and Fe oxides

B Liu, C Wei, D Wei, M Chen, W Li, P Pan, B Lin, L Wu, Q Li, Z He

Agriculture, Ecosystems Environment (Elsevier) China, USA, 10 November 2022

Ecology

Key words: Tropical soil, Corn-pepper rotation, Fertilization, Heavy metal, Soil aggregates

Organism: Soil

379
Transthyretin attenuates TDP-43 proteinopathy by autophagy activation via ATF4 in FTLD-TDP

YP Chu, LW Jin, LC Wang, PC Ho, WY Wei, KJ Tsai

Brain (Oxford Academic) Taiwan, USA, 10 November 2022

Cell Biology

Key words: TTR, TDP 43, proteinopathy, ATF4, FTLD

Organism: Mouse

Tissue: Brain

380
Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone cement to repair critical bone defects

S Li, L Zhang, C Liu, J Kim, K Su, T Chen, L Zhao, X Lu, H Zhang, Y Cui, X Cui, F Yuan, H Pan

Bioactive Materials (Elsevier) China, 09 November 2022

Osteology

Key words: Borosilicate glass bone cement, Immunomodulation, Angiogenesis, Osteogenesis

Organism: Rabbit

Tissue: Bone

381
Expression and clinical significance of VISTA, B7-H3, and PD-L1 in glioma

LC Wang, YL Wang, B He, YJ Zheng, HC Yu, ZY Liu, RR Fan, X Zan, RC Liang, ZP Wu, X Tang, GQ Wang, JG Xu, LX Zhou

Clinical Immunology (Elsevier) China, 08 November 2022

Oncology

Key words: VISTA, B7-H3, PD-L1, Glioma, mIF

Organism: Human

Tissue: Brain

Pathological State: Cancer

382
Influence of PRRSV-1 vaccination and infection on mononuclear immune cells at the maternal-fetal interface.

MR Stas, H Kreutzmann, J Stadler, EL Sassu, KH Mair, M Koch, C Knecht, M Stadler, M Dolezal, G Balka, M Zaruba, M Mötz, A Saalmüller, T Rümenapf, W Gerner, A Ladinig

Frontiers in Immunology (Frontiers Media S.A.) Austria, Germany, 08 November 2022

Virology, Immunology

Key words: PRRSV, porcine maternal-fetal interface, NK cells, γδ T cells, B cells, CD4 T cells, CD8 T cells

Organism: Pig

Tissue: Placenta

383
Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia

WC Schrottmaier, JB Kral-Pointner, M Salzmann, M Mussbacher, A Schmuckenschlager, A Pirabe, L Brunnthaler, M Kuttke, B Maier, S Heber, H Datler, Y Ekici, B Niederreiter, U Heber, B Blomgren, AD Gorki, C Söderberg-Nauclé, B Payrastre, MP Gratacap, S Knapp, G Schabbauer, A Assinger

Cell Reports (Cell Press) Austria, Sweden, France, 08 November 2022

Immunology

Key words: platelet, PI3K, p110 inhibitor, streptococcus, pneumonia, infection, inflammation, leukocyte recruitment, immunomodulation

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

384
An Early Islet Transcriptional Signature is Associated with Local Inflammation in Autoimmune Diabetes

AG Derr, A Arowosegbe, B Satish, SD Redick, N Qaisar, Z Guo, E Vanderleeden, MI Trombly, CE Baer, DL Greiner, M Garber, JP Wang

Diabetes (American Diabetes Association) USA, 08 November 2022

Endocrinology

Key words: Type 1 diabets, autoimmune disease/disorders, rat pancreatic islet, virus, single-cell RNA (scRNA) sequencing

Organism: Rat

Tissue: Pancreas

Pathological State: Diabetes Type 1

385
Proteome expression profiling of red blood cells during the tumorigenesis of hepatocellular carcinoma

S Wang, G Wang, S Lu, J Zhang, W Zhang, Y Han, X Cai, Y Zhuang, F Pu, X Yan, Z Tu, L Wang, X Huang, B Fan, D Wang, Z Zhang

Plos one (Plos) China, 08 November 2022

Oncology

Key words: Lung and intrathoracic tumors, Hepatocellular carcinoma, Carcinogenesis, Blood, Biomarkers, Cancer detection and diagnosis, Hemoglobin, Globins

Organism: Human

Tissue: Liver

Pathological State: Cancer

386
Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1, 2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway

Y Zheng, N Gao, W Zhang, R Ma, F Chi, Z Gao, N Cong

Molecular Neurobiology (Springer) China, 05 November 2022

Pharmacology

Key words: Melatonin, Pyroptosis, Cochlear hair cell, Oxygen–glucose deprivation/reperfusion

Cell Line: HEI-OC1 cells

387
Prx1+ MPCs Accumulate in the Dura Mater of Wild‐Type and p21−/− Mice Followed by a Specific Reduction in p21−/− Dural MPCs

SS Shah, PT Salo, FG Lyons, AP Mitha, RJ Krawetz

Advanced Biology (Wiley) Canada, 03 November 2022

Physiology

Organism: Mouse

Tissue: Adipose Tissue

388
Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions

N Yang, Y Wang, Q Tian, Q Wang, Y Lu, L Sun, S Wang, Y Bei, J Ji, H Zhou, W Yang, P Yao, W Zhu, L Sun, Z Huang, X Li, P Shen

Cell Death & Differentiation (Nature) China, USA, 03 November 2022

Cell Biology

Key words: Cell biology, Molecular biology

Organism: Human

Tissue: Adipose Tissue

389
Association of neutrophil extracellular traps with fistula healing in patients with complex perianal fistulising Crohn's disease

D Cao, K Qian, Y Zhao, J Hong, H Chen, X Wang, N Yang, C Zhang, J Cao, K Jia, G Wu, M Zhu, J Shen, Y Zhang, Z Cui, Z Wang

Journal of Crohn's and Colitis (Oxford Academic) China, 02 November 2022

Gastroenterology

Key words: Perianal fistulising Crohn's disease, Neutrophil extracellular traps, Fistula healing

390
Aberrant Expression of Thymosin Beta-4 Correlates With Advanced Disease and BRAF V600E Mutation in Thyroid Cancer

CY Kuo, JY Jhuang, WC Huang, SP Cheng

Journal of Histochemistry & Cytochemistry (SAGE Journals) Taiwan, 02 November 2022

Oncology, Genetics

391
p38α in the preoptic area inhibits brown adipose tissue thermogenesis

J Wang, S Wu, H Zhan, W Bi, Y Xu, Y Liang, Y Ge, L Peng, X Jin, K Lu, J Zhao, L Gao, Z He

Obesity (Wiley) China, 02 November 2022

Endocrinology

Organism: Mouse

Tissue: Liver, Adipose Tissue

392
Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma

M Mo, X Ma, Y Luo, C Tan, B Liu, P Tang, Q Liao, S Liu, H Yu, D Huang, X Zeng, X Qiu

BMC Cancer (BMC) China, 26 October 2022

Oncology

Key words: Hepatocellular carcinoma, Liver-specific lncRNA, FAM99A, Prognosis, Tumor growth

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

393
Whole-brain mapping of metabolic alterations in a mouse model of Alzheimer's disease by desorption electrospray ionization mass spectrometry imaging

X Wang, X Yang, Z Hou, S Tian, G Xu, J Li, L Wen, D Bi, F Gao, Y Shen, G Huang

Talanta (Elsevier) China, 26 October 2022

Neuroscience

Key words: Alzheimer's disease, Mass spectrometry imaging, Metabolic pathway, Glutamine-glutamate/GABA cycle, Neuronal activity

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

394
A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

L Liang, J Huang, K Cui, P Li, W Shi, F Lin, G Hao, S Sun

International Journal of Molecular Sciences (MDPI) China, 24 October 2022

Immunology, Infectious Diseases

Key words: Salmonella Typhimurium, phage cocktail, immunophage synergy, lysis from without, phage resistance

Organism: Mouse

Tissue: Spleen, Liver, Kidney, Lung

Pathological State: Salmonella Typhimurium Infection

395
Tumor infiltrating CD8/CD103/TIM-3-expressing lymphocytes in epithelial ovarian cancer co-express CXCL13 and associate with improved survival

M Vlaming, V Bilemjian, JÁ Freile, V Melo, A Plat, G Huls, HW Nijman, M de Bruyn, E Bremer

Frontiers in Immunology (Frontiers Media S.A.) The Netherlands, 21 October 2022

Oncology

Key words: CXCL13, RNA-seq, TIM-3, epithelial ovarian cancer, tumor infiltrating lymphocytes

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

396
HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control

R Fardoos, S Nyquist, O Asowata, SW Kazer, A Singh, A Ngoepe, J Giandhari, N Mthabela, D Ramjit, S Singh, F Karim, S Buus, F Anderson, JZ Porterfield, AL Sibiya, R Bipath, K Moodley, W Kuhn, B Berger, S Nguyen, T de Oliveira, T Ndung'u, P Goulder, AK Shalek, A Leslie, HN Kløverpris

Frontiers in Immunology (Frontiers Media S.A.) South Africa, Denmark, USA, UK, 18 October 2022

Immunology

Key words: CD8+ TRM cells, HIV, PD-1, tonsils, exhaustion, natural HIV control

Organism: Human

Tissue: Tonsil

Pathological State: HIV Infection

397
Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment

V Rajeev, DY Fann, QN Dinh, HA Kim, TM De Silva, DG Jo, GR Drummond, CG Sobey, MKP Lai, CLH Chen, TV Arumugam

International Journal of Biological Sciences (Ivyspring International Publisher) Singapore, Australia, South Korea, 17 October 2022

Neuroscience

Key words: Vascular dementia, Vascular cognitive impairment, Intermittent fasting, Neuronal death, White matter lesions, Blood brain barrier breakdown, Chronic cerebral hypoperfusion

Organism: Mouse

Tissue: Brain

398
Nano-integrated Cascade Antioxidase Opsonized by Albumin Bypass the Blood-Brain Barrier for Ischemia-Reperfusion Injury

W Wang, Z Zhang, Y Liu, L Kong, W Li, W Hu, Y Wang, X Liu

Biomaterials Science (Royal Society of Chemistry) China, 17 October 2022

Nanomedicine

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

399
Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains

X Chen, Y Sun, L Chen, X Chen, M Pan, Y Zhang, Q Wang, W Yang, P Yin, D He, X Guo, S Yang, Y Zeng, S Yan, XJ Li, S Li

Cellular and Molecular Life Sciences (Springer) China, 17 October 2022

Neuroscience

Key words: Huntington disease, Neurogenesis, Aging, Neurodegeneration, Primate

Organism: Mouse, Monkey

Tissue: Brain

400
The NQO1/p53/SREBP1 axis promotes hepatocellular carcinoma progression and metastasis by regulating Snail stability

X Wang, Y Liu, A Han, C Tang, R Xu, L Feng, Y Yang, L Chen, Z Lin

Oncogene (Nature) China, 17 October 2022

Oncology

Key words: Cancer metabolism, Tumour angiogenesis, Tumour biomarkers

Organism: Human

Tissue: Liver

Pathological State: Cancer

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