P2X7 receptor

FEATURED PUBLICATION

P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma
Frontiers in Oncology

Arnaud-Sampaio et al. addressed the persistent problem of drug resistance in cancer and elucidated the role of the P2X7 receptor in chemoresistance, using TissueFAXS platform for image acquisition and StrataQuest software for in-depth cytometric quantifications. The paper was published in Frontiers in Oncology.

Cytotoxic CD8+ T cells may be drivers

FEATURED PUBLICATION

Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome
scientific reports

In this study, published in scientific reports Nature, Kaneko et al. investigated the role of CD4+ and CD8+ T cell subsets in salivary glands of patients with Sjögren’s syndrome. In order to perform an in-depth quantitative analysis, the power of TissueFAXS platform, and both TissueQuest and StrataQuest software were utilized.

Adverse Effects of Single

FEATURED PUBLICATION

A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells
cancers

This study from Liang et al. (University of Gothenburg) assessed phenotypic and functional characteristics of tumor infiltrating lymphocytes within colorectal liver metastases (CRLM). For the in-situ tissue cytometry analysis, with the main focus on CD103+CD8+ TRM cells, the power of TissueFAXS CHROMA and StrataQuest was utilized.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

The role of S100A9

FEATURED PUBLICATION

The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells
Cancer Immunology, Immunotherapy

Kung et al. recently published a study, in the journal Cancer, evaluating the prognostic role of S100A9 (acting as chemoattractant for circulatory monocytes) in pancreatic ductal adenocarcinoma as well as its influence on PD-L1 expression. TissueFAXS PLUS and StrataQuest were used to assess co-expression of PD-L1 and S100A9 in human PDAC tissues.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Differential localization

FEATURED PUBLICATION

Differential localization and limited cytotoxic potential of duodenal CD8+ T cells
The Journal of Clinical Investigation

In a recent study published in The Journal of Clinical Investigation, Mvaya et al. were able to demonstrate the limited potential of duodenal CD8+ T cells in tissue samples from people living with HIV. High content immunophenotyping within duodenal tissue sections was performed using TissueFAXS i PLUS and the single cell analysis software TissueQuest.

Azvudine

FEATURED PUBLICATION

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients
Signal Transduction and Targeted Therapy

Zhang et al, published a study in the journal Signal Transduction Targeted Therapy, with the main focus on the investigation of the effect of Azvudine, in SARS-CoV-2 infected rhesus macaques as well as in COVID-19 patients. The group used TissueFAXS Q as well as TissueQuest to quantify the viral load, immune-status and TUNEL staining within thymus tissues.

Functional Impairment

FEATURED PUBLICATION

Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia
Immunity

In a recent study published in the journal Immunity, Collins et al (Ragon Institute of MGH, MIT and Harvard) were able to show key immunologic and virologic parameters of durable HIV control. For high resolution visualization of the virus, lymph node tissues were marked with HIV specific RNAScope probes and acquired using TissueFAXS Q.

AC-265347 Inhibits

FEATURED PUBLICATION

AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia
International Journal of Molecular Sciences

This recently published study was conducted within the CaSR Biomedicine Training network. Gonçalves-Alves et al. were able to demonstrate the inhibitory effect of the drug AC-265347 on neuroblastoma tumor growth. Expression of various markers (Ki67, CaSR, CD44, TrkA, NF68) was assessed by using TissueFAXS PLUS and StrataQuest.

Filter publications

Customer Publications (A total of 2213 papers published)

201
Food Allergen Nitration Enhances Safety and Efficacy of Oral Immunotherapy in Food Allergy

N Samadi, L Koidl, M Salzmann, M Klems, N Komatitsch, D Schaffer, E Weidmann, A Duschi, J Horejs-Hoeck, E Untersmayr

Nutrients (MDPI) Austria, 25 March 2022

Allergy Research

Key words: oral immunotherapy, food allergy, protein nitration, modulated immune response

Organism: Mouse

Tissue: Stomach

Pathological State: Allergy

202
Effects of Magnetite Nanoparticles and Static Magnetic Field on Neural Differentiation of Pluripotent Stem Cells

AT Semeano, FA Tofoli, JC Corrêa-Velloso, AP de Jesus Santos, Á Oliveira-Giacomelli, RR Cardoso, MA Pessoa, E Lummertz da Rocha, G Ribeiro, MZR Ferrari, LV Pereira, YD Teng, DFS Petri, H Ulrich

Stem Cell Reviews and Reports (Springer) Brazil, USA, 24 March 2022

Stem Cell Research, Nanomedicine

Key words: Neural differentiation, Magnetic nanoparticles, Magnetic field, Biomagnetic effects, Embryonic stem cells, iPSCs, Dopaminergic neurons

Organism: Human

Cell Line: Induced dopaminergic neurons

203
Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells Mitigate Endoplasmic Reticulum Stress, Inflammation, and Lung Injury in Lipopolysaccharide-Treated Obese Mice

MD Chiang, CY Chang, HJ Shih, VL Le, YH Huang, CJ Huang

Antioxidants (MDPI) Taiwan, Vietnam, 23 March 2022

Endocrinology

Key words: lung injury, obesity, endoplasmic reticulum stress, exosomes, LPS

Organism: Mouse

Tissue: Lung

Pathological State: Obesity

204
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway

Y Li, H Liu, X Liu, B Xiao, M Zhang, Y Luo, M Li, J Yang

Frontiers in Oncology (Frontiers Media S.A.) China, 22 March 2022

Oncology, Pharmacology

Key words: gracillin, non-small cell lung cancer, autophagy, mTOR signaling pathway, anti-tumor

Organism: Mouse

Tissue: Heart, Liver, Kidney, Lung, Xenograft Tumor

Pathological State: Cancer

205
A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer

PH Chou, CK Luo, N Wali, WY Lin, SK Ng, CH Wang, M Zhao, SW Lin, PM Yang, PJ Liu, JJ Shie, TT Wei

Journal of Biomedical Science (BMC) Taiwan, USA, 22 March 2022

Oncology

Key words: STAT1, Colorectal cancer, Stemness, Angiogenesis, 4’,5,7-trihydroxyisoflavone (THIF), BODIPY-THIF

Organism: Human

Tissue: Colon

Pathological State: Cancer

206
Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model

H Scherthan, SQ Wagner, J Grundhöfer, N Matejka, J Müller, S Müller, S Rudigkeit, M Sammer, S Schoof, M Port, J Reindl

Cancers (MDPI) Germany, 17 March 2022

Radiotherapy

Key words: 53BP1, cell death, DNA damage, epidermis, γ-H2AX, proton minibeam radiation therapy, DNA repair, skin model

Organism: Human

Cell Line: Human reconstructed epidermis (epiCS®) models

207
Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis

M Wu, X Zhang, W Zhang, YS Chiou, W Qian, X Liu, M Zhang, H Yan, S Li, T Li, X Han, P Qian, S Liu, Y Pan, PE Lobie, T Zhu

Nature communications (Nature) China, Taiwan, 16 March 2022

Oncology

Key words: Breast cancer, Cancer stem cells, Cancer therapy, Metastasis, Tumour heterogeneity

Organism: Human

Tissue: Breast, Lymphoid Tissue

Pathological State: Cancer

208
Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway

J Lv, Y Liu, S Mo, Y Zhou, F Chen, F Cheng, C Li, D Saimi, M Liu, H Zhang, K Tang, J Ma, Z Wang, Q Zhu, WM Tong, B Huang

Nature Cell Biology (Nature) China, 15 March 2022

Oncology

Key words: Glycoproteins, Mechanisms of disease, Pancreatic cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

209
Regorafenib Reverses Temozolomide-Induced CXCL12/CXCR4 Signaling and Triggers Apoptosis Mechanism in Glioblastoma

I Chiang, YC Liu, HS Liu, AAA Ali, SY Chou, TI Hsu, FT Hsu

Neurotherapeutics (Springer) Taiwan, 10 March 2022

Oncology

Key words: Glioblastoma, Temozolomide, Regorafenib, NF-κB, CXCR4/CXCL12

Organism: Mouse

Tissue: Brain, Xenograft Tumor

Pathological State: Cancer

210
hsa-miR-875-5p inhibits tumorigenesis and suppresses TGF-β signalling by targeting USF2 in gastric cancer

S Gao, Z Zhang, X Wang, Y Ma, C Li, H Liu, C Jing, L Li, X Guo

Journal of Translational Medicine (Springer) China, 07 March 2022

Oncology

Key words: miR-875-5p, USF2, Gastric cancer, TGF-β

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

211
Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy

W Jiang, W Dong, M Li, Z Guo, Q Wang, Y Liu, Y Bi, H Zhou, Y Wang

ACS NANO (ACS Publications) China, 03 March 2022

Oncology

Key words: Nitric oxide, Immunogenic cell death, NO nanogenerator, Vaccination effects, PD-1 blockade therapy

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

212
Low miR-10b-3p associated with sorafenib resistance in hepatocellular carcinoma

YY Shao, PS Chen, LI Lin, BS Lee, A Ling, AL Cheng, C Hsu, DL Ou

British Journal of Cancer (Nature) Taiwan, USA, 02 March 2022

Oncology

Key words: Hepatocellular carcinoma, Tumour biomarkers

Organism: Mouse

Tissue: Liver, Xenograft Tumor

Pathological State: Cancer

213
Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

MA Shields, C Spaulding, AE Metropulos, MG Khalafalla, TND Pham, HG Munshi

Cell Reports (Cell Press) USA, 01 March 2022

Oncology

Key words: Gα13, KC mouse model, KPC mouse model, Human PDAC tumors, E-cadherin, mTOR, Rapamycin

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

214
Immunoarchitectural patterns as potential prognostic factors for invasive ductal breast cancer

X Du, Z Zhou, Y Shao, K Qian, Y Wu, J Zhang, M Cui, J Wang, S Wang, Y Tai

npj Breast Cancer (Nature) China, 28 February 2022

Oncology

Key words: Breast cancer, Prognostic markers

Organism: Human

Tissue: Breast

Pathological State: Cancer

215
Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus

JH Lee, C Ostalecki, T Oberstein, S Schierer, E Zinser, M Eberhardt, K Blume, B Plosnita, L Stich, H Bruns, R Coras, J Vera-Gonzales, M Maler, AS Baur

EBioMedicine (Elsevier) Germany, Austria, 25 February 2022

Neuroscience

Key words: Alzheimer's disease, Plasma extracellular vesicles, Choroid plexus, Hippocampus, Hyaluronan, Hyaluronic acid synthetase, Secretases, BACE, Aβ, APP

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

216
EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma

J Ingruber, J Dudás, D Savic, G Schweigl, TB Steinbichler, M do Carmo Greier, M Santer, S Carollo, Z Trajanoski, H Riechelmann

Experimental Cell Research (Elsevier) Austria, 25 February 2022

Oncology

Key words: Mesenchymal-to-epithelial transition, Cell-transfection, TissueFax, UPCI-SCC090, SCC25, FaDu

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

217
Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms

X Guo, X Jin, K Han, S Kang, S Tian, X Lv, M Feng, H Zheng, Y Zuo, G Xu, M Hu, J Xu, P Lv, YZ Chang

Free Radical Biology and Medicine (Elsevier) China, 24 February 2022

Neuroscience

Key words: Iron, Ischemic stroke, Gliosis, Synaptic plasticity, Myelination, Nerve regeneration

Organism: Mouse

Tissue: Brain

Pathological State: Stroke

218
Tumor Necrosis Factor-α Mediates Lung Injury in the Early Phase of Endotoxemia

KY Chen, CY Chang, HJ Hsu, HJ Shih, IT Huang, HH Patel, CJ Huang

Pharmaceuticals (MDPI) Taiwan, Australia, 24 February 2022

Pulmonology

Key words: lung injury, endotoxin, cytokines, cytokine receptors, peptide, mice

Organism: Mouse

Tissue: Lung

Pathological State: Endotoxemia

219
Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation

J Gao, H Mei, J Sun, H Li, Y Huang, Y Tang, L Duan, D Liu, Y Pang, Q Wang, Y Gao, K Song, J Zhao, C Zhang, J Liu

Advanced Biology (Wiley) China, Australia, 23 February 2022

SARS-CoV-2, Osteology

Organism: Human

Pathological State: SARS-CoV-2 Infection

Cell Line: Bone marrow cells

220
High farnesoid X receptor expression predicts favorable clinical outcomes in PD‑L1low/negative non‑small cell lung cancer patients receiving anti‑PD‑1‑based chemo‑immunotherapy

L Wang, X Xu, B Shang, J Sun, B Liang, X Wang, W You, S Jiang

International Journal of Oncology (Spandidos Publications) China, 23 February 2022

Oncology

Key words: Farnesoid X receptor, Predictor, anti‑PD‑1‑based, Chemo‑immunotherapy, Non‑small cell lung cancer, PD‑L1low/negative patients

Organism: Human

Tissue: Lung

Pathological State: Cancer

221
Prompt Antiviral Action of Pulmonary CD8+ TRM Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung

L Jiang, L Liu, M Zhang, L Zhang, C Zhu, Q He, L Ye, C Zhao, Z Li, J Xu, X Zhang

Frontiers in Immunology (Frontiers Media S.A.) China, 22 February 2022

Immunology

Key words: influenza, lung-resident memory CD8 T cells, IFN-γ, interferon-induced genes, inflammatory cytokines

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection

222
Meloxicam Inhibits Hepatocellular Carcinoma Progression and Enhances the Sensitivity of Immunotherapy via the MicroRNA-200/PD-L1 Pathway

S Guangshun, S Guoqiang, C Xin, K Xiangyi, Z Wubin, L Zhitao, Z Zhiying, C Hongyong, L Chengyu, X Yongxiang, T Weiwei

Journal of Oncology (Hindawi Publishing Corporation) China, 21 February 2022

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

223
TSPAN6 is a suppressor of Ras-driven cancer

PO Humbert, TZ Pryjda, B Pranjic, A Farrell, K Fujikura, R de Matos Simoes, R Karim, I Kozieradzki, SJF Cronin, GG Neely, TF Meyer, A Hagelkruys, HE Richardson, JM Penninger

Oncogene (Nature) Australia, Austria, Germany, Canada, 19 February 2022

Oncology

Key words: Cancer genetic, Cell polarity, Growth factor signalling

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

224
Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects

YH Chan, KN Ho, YC Lee, MJ Chou, WZ Lew, HM Huang, PC Lai, SW Feng

Stem Cell Research & Therapy (Springer) Taiwan, USA, 19 February 2022

Osteology

Key words: Melatonin, Dental pulp mesenchymal stem cells, Osteogenesis, COX2/NF-κB, p38/ERK signaling pathwaym, Bone regeneration, Calvarial bone defect

Organism: Rabbit

Tissue: Bone

225
The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

F Niu, P Han, J Zhang, Y She, L Yang, J Yu, M Zhuang, K Tang, Y Shi, B Yang, C Liu, B Peng, SJ Ji

Elife (eLife Sciences Publications) China, 18 February 2022

Neuroscience

Organism: Mouse

Tissue: Brain

226
Imaging net retrograde axonal transport in vivo: a physiological biomarker

PTJ Lee, Z Kennedy, Y Wang, Y Lu, C Cefaliello, Ö Uyan, CQ Song, BM da Cruz Godinho, Z Xu, M Rusckowski, W Xue, RH Brown

Annals of Neurology (Wiley) USA, 17 February 2022

Medical Imaging

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

227
Quantitative Characterization of Macrophage, Lymphocyte, and Neutrophil Subtypes Within the Foreign Body Granuloma of Human Mesh Explants by 5-Marker Multiplex Fluorescence Microscopy

U Klinge, A Dievernich, J Stegmaier

Frontiers in Medicine (Frontiers Media S.A.) Germany, 15 February 2022

Medical Image Analysis

Key words: Foreign body granuloma, Mesh, Multiplex, Fluorescence, Macrophage, Lymphocyte, Neutrophil

Organism: Human

Tissue: Surgical mesh

228
Cordycerebroside A inhibits ICAM‐1‐dependent M1 monocyte adhesion to osteoarthritis synovial fibroblasts

KT Lee, CH Su, SC Liu, BC Chen, JW Chang, CH Tsai, WC Huang, CJ Hsu, WC Chen, YC Wu, CH Tang

Journal of Food Biochemistry (Wiley) Taiwan, 15 February 2022

Rheumatology

Key words: Adhesion, Cordycerebroside A, ICAM-1, M1 macrophage, Osteoarthritis

Organism: Human, Rat

Tissue: Joint Tissue

229
A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+ CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy

D Wang, J Fang, S Wen, Q Li, J Wang, L Yang, W Dai, H Lu, J Guo, Z Shan, W Xie, X Liu, L Wen, J Shen, A Wang, Q Chen, Z Wang

International Journal of Oral Science (Nature) China, 14 February 2022

Oncology

Key words: Cancer microenvironment, Head and neck cancer

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

230
Cell-Penetrating Botulinum Neurotoxin Type A With Improved Cellular Uptake and Therapeutic Index

X Wei, L Li, Y Wu, J Liu

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) China, 11 February 2022

Biological Methods, Neuroscience

Key words: Cell-penetrating peptides, Zinc finger proteins, Botulinum neurotoxin type A, Cellular uptake, Therapeutic index

Organism: Mouse

Tissue: Muscle

231
H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice

L Ruilian, Q Honglin, X Jun, L Jianxin, B Qingyun, C Yilin, M Haifeng

Journal of Affective Disorders (Elsevier) China, 10 February 2022

Neuroscience

Key words: Chronic stress stimulated depression model, Hippocampus, Hydrogen sulfide, Inflammatory, Aerobic exercise

Organism: Mouse

Tissue: Brain

Pathological State: Depression

232
The effects of hypoxia on mitochondrial function and metabolism in gastric cancer cells

J Jiang, Y Jiang, YG Zhang, T Zhang, JH Li, DL Huang, J Hou, MY Tian, L Sun, XM Su, Y Dong, YY Ma

Translational Cancer Research (AME Publishing Company) China, 10 February 2022

Oncology

Key words: Gastric cancer, Hypoxia, Mitochondrial function, Aerobic respiration

Organism: Mouse

Pathological State: Cancer

Cell Line: Gastric cancer line MKN45

233
MYC/MAX-Activated LINC00958 Promotes Lung Adenocarcinoma by Oncogenic Transcriptional Reprogramming Through HOXA1 Activation.

T Zhang, F Su, YB Lu, XL Ling, HY Dai, TN Yang, B Zhang, D Zhao, XM Hou

Frontiers in Oncology (Frontiers Media S.A.) China, 09 February 2022

Oncology

Key words: Lung adenocarcinoma, LINC00958, MYC, MAX, Transcriptional reprogramming, HOXA1

Organism: Human

Tissue: Lung

Pathological State: Cancer

234
Colonic Leucine-Rich Repeat Kinase 2 Expression Is Increased and Associated With Disease Severity in Patients With Parkinson's Disease

PH Liao, HL Chiang, CT Shun, JF Hang, HM Chiu, MS Wu, CH Lin

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 08 February 2022

Neuroscience

Key words: Parkinson’s disease, Colon biopsy, Leucine-rich repeat kinase 2, Inflammatory bowel diseases, Biomarker (BM)

Organism: Human

Tissue: Colon

Pathological State: Parkinson's disease

235
Differential localization and limited cytotoxic potential of duodenal CD8+ T cells

L Mvaya, T Khaba, AE Lakudzala, T Nkosi, N Jambo, I Kadwala, A Kankwatira, PD Patel, MA Gordon, TS Nyirenda, KC Jambo, ZM Ndhlovu

JCI Insight (American Society for Clinical Investigation) Malawi, South Africa, UK, USA, 08 February 2022

Immunology

Organism: Human

Tissue: Small Intestine

236
Assessment of Physiological Rat Kidney Ageing—Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation

A Baumgartner, S Reichelt-Wurm, W Gronwald, C Samol, JA Schröder, C Fellner, K Holler, A Steege, FJ Putz, PJ Oefner, B Banas, MC Banas

Metabolites (MDPI) Germany, 08 February 2022

Transplantation Medicine, Nephrology

Key words: Kidney, Ageing, Transplantation, Inflammation, Urinary metabolites

Organism: Rat

Tissue: Kidney

237
ATP8B1 Knockdown Activated the Choline Metabolism Pathway and Induced High-Level Intracellular REDOX Homeostasis in Lung Squamous Cell Carcinoma

X Zhang, R Zhang, P Liu, R Zhang, J Ning, Y Ye, W Yu, J Yu

Cancers (MDPI) China, 07 February 2022

Oncology

Key words: ATP8B1, LUSC, CHKA, REDOX

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

238
Effect of Helicobacter pylori-associated chronic gastritis on autonomous activity and sleep quality in mice

H Liu, W Zheng, L Zhang, T Lin, Y Tang, L Hu

Frontiers in Pharmacology (Frontiers Media S.A.) China, 04 February 2022

Microbiology, Gastroenterology

Key words: Autonomous activity, Chronic gastritis, Helicobacter pylori, Mouse behavior, Sleep quality

Organism: Mouse

Tissue: Stomach

Pathological State: Gastritis

239
Multi-Factorial Nerve Guidance Conduit Engineering Improves Outcomes in Inflammation, Angiogenesis and Large Defect Nerve Repair

AJ Hibbitts, Z Kočí, S Kneafsey, A Matsiko, L Žilić, A Dervan, P Hinton, G Chen, B Cavanagh, JK Dowling, CE McCoy, CT Buckley, SJ Archibald, FJ O'Brien

Matrix Biology (Elsevier) Ireland, USA, 04 February 2022

Neuroscience

Key words: Peripheral Nerve, Biomaterials, Extracellular Matrix, Nerve Guidance Conduit, Angiogenesis, Inflammation

Organism: Rat

Tissue: Nerves

240
Tegaserod Maleate Inhibits Breast Cancer Progression and Enhances the Sensitivity of Immunotherapy

X Li, L Wu, Z Zheng, H Liu, H Li, G Sun, G Sun, Y Cheng, H Wang, Z Li, J Shi, W Tang

Journal of Oncology (Hindawi Publishing Corporation) China, Germany, 03 February 2022

Oncology, Pharmacology

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

241
Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR) USA, 02 February 2022

Oncology, Immunology

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

242
Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues

M Tsuda, R Horio, L Wang, T Takenami, J Moriya, J Suzuka, H Sugino, Z Tanei, M Tanino, S Tanaka

Scientific Reports (Nature) Japan, 02 February 2022

Biological Methods

Key words: Assay systems, Biotechnology

Organism: Human

Tissue: Colon

Pathological State: Cancer

243
Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond

S Chen, W Li, X Zheng, P Yu, P Wang, Z Sun, Y Xu, D Jiao, X Ye, M Cai, M Shen, M Wang, Q Zhang, F Kong, Y Wang, J He, H Wei, F Shi, J Du

PNAS (United States National Academy of Sciences) China, 01 February 2022

Oncology

Key words: Tumor Tissue, Histological Magnetometry, Nitrogen-Vacancy Center, Micrometer-Resolution Magnetic Imaging, Absolute Magnetic Quantification

Organism: Human

Tissue: Lung

Pathological State: Cancer

244
PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through β-catenin dysregulation

BY Ahn, MH Jeong, JH Pyun, HJ Jeong, TA Vuong, JH Bae, S An, SW Kim, YK Kim, D Ryu, HJ Kim, H Cho, GU Bae, JS Kang

Cellular and Molecular Life Sciences (Springer) South Korea, 28 January 2022

Cardiology

Key words: PRMT7, Cardiomyopathy, Wnt, β-catenin

Organism: Rat

Pathological State: Cardiac Fibrosis

Cell Line: Neonatal rat ventricular myocyte (NRVM) cells

245
Regorafenib enhances antitumor immune efficacy of anti-PD-L1 immunotherapy on oral squamous cell carcinoma

IT Chiang, YH Lee, ZL Tan, FT Hsu, HF Tu

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 26 January 2022

Oncology, Pharmacology

Key words: Oral squamous cells carcinoma, Regorafenib, Anti-PD-L1, Antitumor-induced immunity

Organism: Mouse

Tissue: Mucosa

Pathological State: Cancer

246
Metastatic Tumor Antigen 1 Contributes to Hepatocarcinogenesis Posttranscriptionally Through Novel RNA Binding Function

YT Li, CJ Liu, JH Kao, LF Lin, HC Tu, CC Wang, PH Huang, HR Cheng, PJ Chen, DS Chen, HL Wu

Hepatology (Wiley) Taiwan, 24 January 2022

Oncology

Key words: RNA stability, Post-transcriptional control, Tumorigenic capacity, Self-renewal and anchorage-independent growth, Carcinogenesis

Organism: Human

Tissue: Liver

Pathological State: Cancer

247
Inhibition of β-catenin signaling attenuates arteriovenous fistula thickening in mice by suppressing myofibroblasts

CT Liu, SC Hsu, HL Hsieh, CH Chen, CY Chen, YM Sue, TH Chen, YH Hsu, FY Lin, CM Shih, YT Shiu, PH Huang

Molecular Medicine (BMC) Taiwan, USA, 21 January 2022

Nephrology

Key words: Arteriovenous fistula (AVF), β-catenin, Hemodialysis, Myofibroblast

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney disease

248
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach

D Douchi, A Yamamura, J Matsuo, JW Lee, N Nuttonmanit, Y Hui, M Lim, K Suda, M Shimura, S Chen, SC Pang, K Kohu, M Kaneko, H Kiyonari, A Kaneda, H Yoshida, I Taniuchi, M Osato, H Yang, M Unno, JBY So, KG Yeoh, LSH Chuang, SC Bae, Y Ito

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) Singapore, Japan, 21 January 2022

Stem Cell Research, Gastroenterology

Key words: Isthmus, Stem/Progenitor Cell, Enhanced Stem Cell Activity, Preneoplastic State, Gastric Carcinogenesis

Organism: Mouse

Tissue: Stomach

249
Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT

N Kane, T Romero, S Diaz-Perez, MB Rettig, ML Steinberg, AU Kishan, D Schaue, RE Reiter, BS Knudsen, NG Nickols

Prostate Cancer and Prostatic Diseases (Nature) USA, 20 January 2022

Oncology

Key words: Cancer therapy, Prostate cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

250
Chidamide and mitomycin C exert synergistic cytotoxic effects against bladder cancer cells in vitro and suppress tumor growth in a rat bladder cancer model

SC Wang, CY Yu, YC Wu, YC Chang, SL Chen, WW Sung

Cancer Letters (Elsevier) Taiwan, 18 January 2022

Oncology

Key words: Urothelial carcinoma, Histone, N-methyl-N-nitrosourea, Deacetylase, Axl

Organism: Rat

Tissue: Bladder

Pathological State: Cancer

251
Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response

AM Gamage, KS Tan, WOY Chan, ZZR Lew, J Liu, CW Tan, D Rajagopalan, QXX Lin, LM Tan, PN Venkatesh, YW Ong, M Thong, RTP Lin, S Prabhakar, DY Wang, LF Wang

mBio (American Society for Microbiology) Singapore, 18 January 2022

SARS-CoV-2, Immunology

Organism: Human

Pathological State: COVID-19

Cell Line: human nasal epithelial stem/progenitor cells (hNESPCs)

252
Repair phase modeling of ischemic acute kidney injury: recovery vs. transition to chronic kidney disease

K Lee, HR Jang, J Jeon, KE Yang, JE Lee, GY Kwon, DJ Kim, W Huh

American Journal of Translational Research (e-Century Publishing Corporation) South Korea, 15 January 2022

Nephrology

Key words: Ischemic acute kidney injury, Chronic kidney disease, Ischemia-reperfusion injury, Recovery, Repair

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

253
Cottonseed protein concentrate as fishmeal alternative for largemouth bass (Micropterus salmoides) supplemented a yeast-based paraprobiotic: Effects on growth performance, gut health and microbiome

X Xie, J Wang, Y Guan, S Xing, X Liang, M Xue, J Wang, Y Chang, E Leclercq

Aquaculture (Elsevier) China, France, 13 January 2022

Zoology

Key words: Cottonseed Protein Concentrate, Largemouth Bass, Paraprobiotic, Gut Health, Gut Microbiome

Organism: Bass Fish

Tissue: Small Intestine

Pathological State: Alzheimer's Disease

254
P2RX7 in dopaminergic neurons of ventral periaqueductal gray mediates HTWP acupuncture-induced consciousness in traumatic brain injury

H Tang, S Qin, W Li, X Chen, L Ulloa, Q Zhu, B Liu, Y Gong, Y Zhao, S Wang, S Li, Y Guo, Z Xu, Y Guo

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China, USA, 13 January 2022

Neuroscience

Key words: Acupuncture, Traumatic Brain Injury, Neural Projection, Dopamine, P2RX7, Ventral Periaqueductal Gray, Hand 12 Jing-Well Points

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

255
Autochthonous Human Dirofilaria repens Infection in Austria

N Geissler, J Ruff, J Walochnik, W Ludwig, H Auer, U Wiedermann, W Geissler

Acta Parasitologica (Springer) Austria, 12 January 2022

Parasitology

Key words: Dirofilariasis · Nematode infections · Parasitic worms · Climate change · Austria

Organism: D. repens

Tissue: Whole Organism

256
Large deletion of Wdr19 in developing renal tubules disrupts primary ciliogenesis leading to polycystic kidney disease in mice

SS Yu, E Wang, CY Chiang, PH Cheng, YS Yeh, YY Wu, YY Chiou, ST Jiang

The Journal of Pathology (Wiley) Taiwan, 10 January 2022

Nephrology

Key words: Wdr19, intraflagellar transport, primary cilia, renal cyst, polycystic kidney disease

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

257
Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease

HC Campos, DE Ribeiro, D Hashiguchi, DY Hukuda, C Gimenes, SAA Romariz, Q Ye, Y Tang, H Ulrich, B Monteiro Longo

Stem Cell Reviews and Reports (Springer) Brazil, China, 08 January 2022

Neuroscience, Stem Cell Research

Key words: Alzheimer’s Disease, Hippocampus, Neural and Mesenchymal Stem Cell Transplantation, Tissue Cytometry, Amyloid-β plaques

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

258
Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin

W Vankrunkelsven, S Derde, J Gunst, S Vander Perre, E Declerck, L Pauwels, I Derese, G Van den Berghe, L Langouche

Journal of Cachexia, Sarcopenia and Muscle (Wiley) Belgium, 07 January 2022

Infectious Diseases, Endocrinology

Key words: Leptin, Critical Illness, Sepsis, Muscle Weakness, Intensive Care Unit Acquired Weakness, Atrophy, Protein Catabolism

Organism: Mouse

Tissue: Muscle

Pathological State: Sepsis, Obesity

259
Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection

FJ Ogunshola, W Smidt, AF Naidoo, TP Nkosi, T Ngubane, PT Khaba, OO Baiyegunhi, B Mahlobo, S Rasehlo, N Ngema, I Jajbhay, KL Dong, V Ramsuran, J Pansegrouw, T Ndung'u, B Walker, T de Oliveria, ZM Ndhlovu

Blood Advances (ASH Publications) South Africa, USA, Germany, 06 January 2022

Immunology

Key words: Immunobiology, Immunotherapy

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

260
Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity

H Wang, Y Fan, W Chen, Z Lv, S Wu, Y Xuan, Chenfeng Wang, Yongliang Lu,Tao Guo,Donglai Shen,Fan Zhang,Qingbo Huang,Yu Gao,Hongzhao Li,Xin Ma,Baojun Wang,Yan Huang &Xu Zhang

OncoImmunology (Taylor & Francis) China, 05 January 2022

Oncology

Key words: CMTM6, DNA Damage, Cellular Senescence, Immunity, Renal Cell Carcinoma

Organism: Human

Pathological State: Cancer

Cell Line: HKC cells, ccRCC cells, HEK293T cells

261
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages

Z Wang, J Lv, P Yu, Y Qu, Y Zhou, L Zhou, Q Zhu, S Li, J Song, W Deng, R Gao, Y Liu, J Liu, WM Tong, C Qin, B Huang

Cellular & molecular Immunology (Nature) China, 04 January 2022

SARS-CoV-2, Immunology

Key words: SARS-CoV-2, Microparticles, Alveolar Macrophages, Endosomes, Lysosomes

Organism: Mouse

Tissue: Lung

Pathological State: COVID-19

262
Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes

CL Ho, LLH Huang, SJ Shieh

Regenerative Biomaterials (Chinese Society for Biomaterials) Taiwan, 04 January 2022

Stem Cell Research

Key words: Chondrocytes, Cell Proliferation, Perichondrial Progenitor Cells, Paracrine Effect, Neocartilage Formation

Organism: Mouse

Tissue: Joint Tissue

263
Stabilization but no functional influence of HIF-1α expression in the intestinal epithelium during Salmonella Typhimurium infection

L Robrahn, A Dupont, S Jumpertz, K Zhang, CH Holland, J Guillaume, S rappold, J Roth, V Cerovic, J Saez-Rodriguez, MW Hornef, T Cramer

Infection and Immunity (American Society for Microbiology) Germany, The Netherlands, 03 January 2022

Immunology, Microbiology

Organism: Mouse

Tissue: Small Intestine, Large Intestine

Pathological State: Salmonella Typhimurium infection

264
Preclinical Safety of a 3D-Printed Hydroxyapatite-Demineralized Bone Matrix Scaffold for Spinal Fusion

M Plantz, J Lyons, JT Yamaguchi, AC Greene, DJ Ellenbogen, MJ Hallman, V Shah, C Yun, AE Jakus, D Procissi, S Minardi, RN Shah, WK Hsu, EL Hsu

Spine (ingentaconnect) USA, 01 January 2022

Osteology

Key words: 3D Printing, Bone Morphogenetic Protein-2, Demineralized Bone Matrix, Host Inflammatory Response, Hydroxyapatite, Spinal Fusion

Organism: Rat

Tissue: Bone

265
Detection of Cytopathic Effects Induced by Influenza, Parainfluenza, and Enterovirus Using Deep Convolution Neural Network

JJ Chen, PH Lin, YY Lin, KY Pu, CF Wang, SY Lin, TS Chen

Biomedicines (MDPI) Taiwan, 28 December 2021

Machine Learning, Virology

Key words: Artificial Intelligence, Cytopathic Effect, ResNet-50

266
The liquid Kangfuxin (KFX) has efficient antifungal activity and can be used in the treatment of vulvovaginal candidiasis in mouse

J Ma, YC Yang, LQ Su, DM Qin, K Yuan, Y Zhang, RR Wang

Letters in Applied Microbiology (Wiley) China, 27 December 2021

Infectious Diseases, Reproductive Medicine

Key words: Candida Albicans, Kangfuxin Liquid, Antifungal, Vaginal Candidiasis, Murine Model

Organism: Mouse

Tissue: Vagina

Pathological State: Candidiasis

267
Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

CY Chang, KY Chen, HJ Shih, M Chiang, IT Huang, YH Huang, CJ Huang

Pharmaceuticals (MDPI) Taiwan, 27 December 2021

Endocrinology

Key words: Obesity, Sepsis, Liver, Exosomes, let-7i

Organism: Mouse

Tissue: Liver

Pathological State: Obesity

268
Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis

J Zhang, L Wang, C Li, H Zhang, R Li, M Li

Systems biology in Reproductive Medicine (Taylor & Francis) China, 27 December 2021

Reproductive Medicine

Key words: Letrozole, Endometriosis, Endometrial Receptivity, Integrin avβ3, HOXA10

Organism: Rat

Tissue: Endometrium

Pathological State: Endometriosis

269
Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells

K Piatek, A Kutner, D Cacsire Castillo-Tong, T Manhardt, N Kupper, U Nowak, M Chodyński, E Marcinkowska, E Kallay, M Schepelmann

International Journal of Molecular Sciences (MDPI) Austria, Poland, 24 December 2021

Endocrinology, Oncology

Key words: Vitamin D, Vitamin D Analogs, 25 Vitamin D 24-Hydroxylase, CYP24A1, Proliferation, High-Grade Serous Ovarian Cancer Cells

Organism: Human

Pathological State: Cancer

Cell Line: Ovarian cancer cells

270
Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression

YH Chu, WC Liao, YJ Ho, CH Huang, TJ Tseng, CH Liu

Cells (MDPI) Taiwan, 20 December 2021

Oncology

Key words: Glioma, Chondroitin Sulfate, CHSY1, Integrin Β1, CD44, Therapeutic Peptide

271
S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 …

K Tanigawa, S Tsukamoto, Y Koma, Y Kitamura, S Urakami, M Shimizu, M Fujikawa, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki

The American Journal of Pathology (Elsevier) Japan, 20 December 2021

Oncology

Organism: Human

Pathological State: Cancer

Cell Line: Peripheral blood monocytes

272
P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease

Y Li, H Zhang, J Yang, M Zhan, X Hu, Y Liu, L Yu, X Yan, S Liang, R Zhang, Y Lu, B Li, C Liu, M Li

Chinese Medicine (Springer) China, 16 December 2021

Gastroenterology

Key words: P2Y12 Receptor, Visceral Pain, Depression, EA, IBD

Organism: Mouse

Tissue: Brain

Pathological State: depression, inflammatory bowel disease

273
Spatial point pattern analysis identifies mechanisms shaping the skin parasite landscape in Leishmania donovani infection

JSP Doehl, H Ashwin, N Brown, A Romano, S Carmichael, JW Pitchford, PM Kaye

Frontiers in Immunology (Frontiers Media S.A.) UK, 16 December 2021

Parasitology

Key words: Leishmania donovani, host cell, dispersion, dispersal, skin patches, spatial point pattern analysis

Organism: Mouse

Tissue: Skin

Pathological State: Leishmaniasis

274
Hedgehog-signalling in papillary fibroblasts is essential for hair follicle regeneration during wound healing

S Frech, A Forsthuber, A Korosec, K Lipp, V Kozumov, BM Lichtenberger

Journal of Investigative Dermatology (Elsevier) Austria, 16 December 2021

Dermatology

Key words: Wound Healing, Dermal Fibroblast Lineages, Hedgehog Signaling, Hair Follicle Neogenesis, WIHN, Papillary and Reticular Fibroblasts, Regeneration

Organism: Mouse

Tissue: Skin

275
CD163+ M2 macrophages promote fibrosis in IgG4‐related disease via TLR7/IRAK4/NF‐κB signaling

A Chinju, M Moriyama, N Kakizoe-Ishiguro, H Chen ,Y Miyahara, AR Haque, K Furusho, M Sakamoto, K Kai, K Kibe, S Hatakeyama-Furukawa, M Ito-Ohta, T Maehara, S Nakamura

Arthritis & Rheumatology (Wiley) Japan, Bangladesh, 15 December 2021

Immunology, Rheumatology

Key words: Igg4-Related Disease, M2 Macrophage, Toll-Like Receptor 7, IL-1 Receptor-Associated Kinase 4, Fibrosis

Organism: Human

Tissue: Salivary Gland

Pathological State: IgG4-Related Disease

276
Nuplazid suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting PAK4

Y Wei, W Wu, Y Jiang, H Zhou, Y Yu, L Zhao, X Wu, X Lu, Q Yuan, Z Wang, Z Dong, L He, J Zhao, K Liu

British Journal of Cancer (Nature) China, 15 December 2021

Oncology

Key words: Cancer Prevention

Organism: Mouse

Tissue: Xenograft Tumor, Esophagus

Pathological State: Cancer

277
Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma

C Wang, Y Huang, X Ma, B Wang, X Zhang

International Journal of Immunpathology and Pharmacology (SAGE Journals) China, 15 December 2021

Oncology

Key words: Clear Cell Renal Cell Carcinoma, NEK2, Prognosis

Organism: Human

Tissue: Kidney

Pathological State: Cancer

278
A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice

K Cao, X Wang, H Peng, L Ding, X Wang, Y Hu, L Dong, T Yang, X Hong, M Xing, D Li, C Zhu, X He, C Zhao, P Zhao, D Zhou, X Zhang, J Xu

Journal of Virology (American Society for Microbiology) China, 15 December 2021

SARS-CoV-2

Key words: COVID-19, Vaccine, SARS-CoV-2 Variants, Influenza, Adenoviral Vector

Organism: Mouse

Tissue: Lung

Pathological State: COVID-19

279
Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development

T Wang, J Zhang, N Li, M Li, S Ma, S Tan, X Guo, Z Wang, Z Wu, L Gao, C Ma, X Liang

Molecular Therapy (Cell Press) China, 15 December 2021

Oncology

Key words: Tim-3, Tim-3 Ligands, Immune Checkpoint Blockade, Tumor Microenvironment, Multiplexed Immunofluorescence

Organism: Human

Tissue: Liver

Pathological State: Cancer

280
Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response

YT Yen, M Chien, PY Wu, CC Ho, CT Ho, KCY Huang, SF Chiang, KSC Chau, WTL Chen, SC Hung

Nature Communications (Nature) Taiwan, 15 December 2021

Oncology, Immunology

Key words: Cancer Immunotherapy, Colon Cancer, Gene Silencing, Immunoediting

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

281
Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

J Chen, J Fan, Z Chen, M Zhang, H Peng, J Liu, L Ding, M Liu, C Zhao, P Zhao, S Zhang, X Zhang, J Xu

PNAS (United States National Academy of Sciences) China, 14 December 2021

SARS-CoV-2

Organism: Human

Pathological State: COVID-19

Cell Line: WT A549 cells

282
Polypharmacological reprogramming of tumor-associated macrophages towards an inflammatory phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR) USA, 13 December 2021

Oncology

Key words: Tumor-Associated Macrophage, Breast Cancer, Tumor Microenvironment, Kinase Inhibitor Screening, Cell-Cell Interaction

Organism: Mouse

Tissue: Allograft Tumor, Lung

Pathological State: Cancer

283
The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model

A Kannan, S Minardi, DJ Ellenbogen, MJ Hallman, AC Greene, JT Yamaguchi, MA Plantz, S Jeong, KC Sana, V Shah, C Yun, EL Hsu, WK Hsu

JOR Spine (Wiley) USA, 13 December 2021

Rheumatology

Key words: Local Steroid, Osteogenesis, Pseudarthrosis, Spine Fusion

Organism: Mouse

Tissue: Bone

Pathological State: Spinal arthrodesis

284
The plasminogen receptor Plg‐RKT regulates adipose function and metabolic homeostasis

F Samad, H Bai, N Baik, P Haider, Y Zhang, G Rega-Kaun, C Kaun, M Prager, J Wojta, Q Bui, S Chakrabarty, J Wang, RJ Parmer, LA Miles

Journal of Thrombosis and Haemostasis (Wiley) USA, Austria, 12 December 2021

Endocrinology

Key words: Adipose Inflammation, Hepatic Steatosis, Insulin Resistance, Obesity, Plg-RKT

Organism: Human

Tissue: Adipose Tissue

Pathological State: Obesity

285
Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension

Z Zhao, Z Guo, Z Yin, Y Qiu, B Zhou

Frontiers in Physiology (Frontiers Media S.A.) China, 10 December 2021

Gastroenterology

Key words: Intra-Abdominal Hypertension, Abdominal Compartment Syndrome, Fecal Microbiota Transplantation, 16S rRNA, Gut Microbiota Dysbiosis

Organism: Rat

Tissue: Liver

Pathological State: Liver Injury

286
FGL1 as a Novel Mediator and Biomarker of Malignant Progression in Clear Cell Renal Cell Carcinoma.

Z Lv, B Cui, X Huang, HY Feng, T Wang, HF Wang, YD Xuan, HZ Li, X Ma, Y Huang, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 09 December 2021

Oncology

Key words: biomarker, clear cell renal cell carcinoma, epithelial to mesenchymal transition, fibrinogen-like protein 1, progression

Organism: Human

Tissue: Kidney

Pathological State: Cancer

287
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

T Zhang, L Sun, Y Hao, C Suo, S Shen, H Wei, W Ma, P Zhang, T Wang, X Gu, ST Li, Z Chen, R Yan, Y Zhang, Y Cai, R Zhou, W Jia, F Huang, P Gao, H Zhang

Nature Cancer (Nature) China, 09 December 2021

Oncology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

288
CD146 as a Prognostic-Related Biomarker in ccRCC Correlating With Immune Infiltrates

Z Lv, HY Feng, W Tao, HZ Li, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 08 December 2021

Oncology

Key words: CD146, ccRCC, prognosis, methylation, tumor microenvironment

Organism: Human

Tissue: Kidney

Pathological State: Cancer

289
Lipid Droplet-Specific Probe for Rapidly Locating Atherosclerotic Plaques and Intraoperative Imaging via In Situ Spraying

M Sang, B Cai, S Qin, S Zhao, Y Mao, Y Wang, X Yu, J Zheng

ACS Applied Materials & Interfaces (ACS Publications) China, 06 December 2021

Biological Methods

Key words: Lipids, Liquids, Fluorescence, Fluorescence Imaging, Probes

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

290
Ascorbic acid-2 glucoside mitigates intestinal damage during pelvic radiotherapy in a rat bladder tumor model

Y Ito, T Yamamoto, K Miyai, J Take, H Scherthan, A Rommel, S Eder, K Steinestel, A Rump, M Port, N Shinomiya, M Kinoshita

International Journal of Radiation Biology (Taylor & Francis) Japan, Germany, 06 December 2021

Oncology, Radiotherapy

Key words: AY-27 Cells, DNA Damage, 53BP1, CD163, M1/M2, Macrophages

Organism: Rat

Tissue: Bladder

Pathological State: Cancer

291
Hedgehog signaling controls bone homeostasis by regulating osteogenic/adipogenic fate of skeletal stem/progenitor cells in mice

L Zhang, X Fu, L Ni, C Liu, Y Zheng, H You, M Li, C Xiu, L Zhang, T Gong, N Luo, Z Zhang, G He, S Hu, H Yang, D Chen, J Chen

Journal of Bone and Mineral Research (Wiley) China, 06 December 2021

Osteology, Stem Cell Research

Key words: Genetic Animal Models, Hedgehogs, Stromal/Stem Cells, Osteoporosis, Aging

Organism: Mouse

Tissue: Bone

292
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

JL Zhang, YH Li, LL Wang, HQ Liu, SY Lu, Y Liu, K Li, B Liu, SY Li, FM Shao, K Wang, N Sheng, R Li, JJ Cui, PC Sun, CX Ma, B Zhu, Z Wang, YH Wan, SS Yu, Y Che, CY Wang, C Wang, Q Zhang, LM Zhao, XZ Peng, Z Cheng, JB Chang, JD Jiang

Signal Transduction and Targeted Therapy (Nature) China, 06 December 2021

SARS-CoV-2

Key words: Drug Development, Infectious Diseases

Organism: Monkey

Tissue: Brain, Lung

Pathological State: COVID-19

293
Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration

M Zou, L Gong, Q Ke, R Qi, X Zhu, W Liu, Q Sun, X Tang, Z Luo, X Gong, Y Liu, DWC Li

Free Radical Biology and Medicine (Elsevier) China, 04 December 2021

Cell Biology

Key words: Age-Related Macular Degeneration, Heterochromatin, Inflammation, Methotrexate, cGAS, STING

Organism: Mouse

Tissue: Eye

Pathological State: Macular degeneration

294
Defect of LSS Disrupts Lens Development in Cataractogenesis.

M Zhao, T Mei, B Shang, B Zou, Q Lian, W Xu, K Wu, Y Lai, C Liu, L Wei, J Zhu, K Zhang, Y Liu, L Zhao

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 02 December 2021

Developmental Biology

Key words: lanosterol synthase, congenital cataract, mouse model, mutation, lens development

Organism: Mouse

Tissue: Eye

Pathological State: Cataract

295
Mad2 Induced Aneuploidy Contributes to Eml4-Alk Driven Lung Cancer by Generating an Immunosuppressive Environment

K Alikhanyan, Y Chen, K Somogyi, S Kraut, R Sotillo

Cancers (MDPI) Germany, 30 November 2021

Oncology

Key words: Lung Cancer, Aneuploidy, Tumor Microenvironment, Immune Suppression, Mouse Models

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

296
Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1

A Lo, K Holmes, S Kamlapurkar, F Mundt, S Moorthi, I Fung, S Fereshetian, J Watson, SA Carr, P Mertins, AH Berger

Science Signaling (Science) USA, 30 November 2021

Oncology

Organism: Human

Cell Line: AALE cells

297
Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy

A Dodd, AA Natfji, A Evangelinos, A Grigoletto, G Pasut, F Beards, L Renshall, HMI Osborn, F Greco, LK Harris

Molecular Pharmaceutics (ACS Publications) UK, Italy, 29 November 2021

Pharmacology

Key words: Polymer−Drug Conjugate PEG Pregnancy Placenta Transport Drug Delivery

Organism: Human

Tissue: Placenta

Pathological State: Pregnancy

298
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

VA Arrieta, AX Chen, JR Kane, SJ Kang, C Kassab, C Dmello, J Zhao, KB Burdett, PS Upadhyayula, C Lee-Chang, J Shilati, D Jaishankar, L Chen, A Gould, D Zhang, J Yuan, W Zhao, X Ling, JK Burks, B Laffleur, C Amidei, JN Bruce, RV Lukas, JT Yamaguchi, D Cieremans, G Rothschild, U Basu, M McCord, DJ Brat, H Zhang, LAD Cooper, B Zhang, P Sims, TF Cloughesy, R Prins, P Canoll, R Stupp, AB Heimberger, C Horbinski, FM Iwamoto, R Rabadan, AM Sonabend

Nature Cancer (Nature) USA, Mexico, France, 29 November 2021

Oncology

Key words: Cancer, Cancer Immunotherapy, CNS Cancer, Tumour Biomarkers

Organism: Human

Tissue: Brain

Pathological State: Cancer

299
Single cell imaging-based chromatin biomarkers for tumor progression

S Venkatachalapathy, DS Jokhun, M Andhari, GV Shivashankar

Scientific Reports (Nature) Singapore, India, Italy, Switzerland, 29 November 2021

Oncology

Key words: Biomarkers, Biophysics, Cancer, Computational Biology and Bioinformatics

Organism: Human

Tissue: Breast

Pathological State: Cancer

300
Lipid‐Activatable Fluorescent Probe for Intraoperative Imaging of Atherosclerotic Plaque Using In Situ Patch

J Zheng, S Zhao, Y Mao, Z Du, G Li, M Sang

Nano Micro Small (Wiley) China, 27 November 2021

Biological Methods

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

301
HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

C Da, J Pu, Z Liu, J Wei, Y Qu, Y Wu, B Shi, J Yang, N He, P Hou

Signal Transduction and Targeted Therapy (Nature) China, 24 November 2021

Oncology

Key words: Cancer, Molecular Biology

Organism: Human

Tissue: Brain

Pathological State: Cancer

302
Mechanism of Chronic Stress-Induced Glutamatergic Neuronal Damage in the Basolateral Amygdaloid Nucleus

S Wang, X Liu, W Shi, Q Qi, G Zhang, Y Li, B Cong, M Zuo

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 23 November 2021

Neuroscience

Organism: Rat

Tissue: Brain

303
Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

C Wang, A Cui, M Bukenya, A Aung, D Pradhan, CA Whittaker, Y Agarwal, A Thomas, S Liang, P Amlashi, H Suh, S Spranger, N Hacohen, DJ Irvine

Cell Reports (Cell Press) USA, 23 November 2021

Immunology, Oncology

Key words: NK Cell, Macrophage, Checkpoint Blockade, Sensitization, Tumor-Targeting Antibody, Interleukin-2, Tumor Microenvironment, Vascular Normalization

Organism: Mouse

Tissue: Allograft Tumor, Skin

Pathological State: Cancer

304
Pectins from various sources inhibit galectin-3-related cardiac fibrosis

AR van der Velde, WC Meijers, HHW Silljé, P Muntendam, MM Dokter, WH van Gilst, HA Schols, RA de Boer

Current Research in Translational Medicine (Elsevier) USA, The Netherlands, 23 November 2021

Cardiology

Key words: Galectin-3, Inhibitor, Pectin, Heart failure, Fibrosis, Affinity

Organism: Human

Cell Line: Monocytes

305
Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds

WH Tsai, CH Chou, TY Huang, HL Wang, PJ Chien, WW Chang, HT Lee

Cells (MDPI) Taiwan, 22 November 2021

Dermatology

Key words: Heat-Killed Probiotics, Lactobacillus, L. Plantarum, L. Paracasei, Skin Wound Healing, Lipoteichoic Acid

Organism: Mouse

Tissue: Skin

Pathological State: Cutaneous Wound

306
Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin-and mucosa-resident memory T cells

S Saluzzo, RV Pandey, LM Gail, R Dingelmaier-Hovorka, L Kleissl, L Shaw, B Reininger, D Atzmüller, J Strobl, V Tonzeau-Römer, A Beer, C Staud, A Rieger, M Farlik, W Weninger, G Stingl, G Stary

Immunity (Cell Press) Austria, 22 November 2021

Immunology, Virology

Key words: HIV, Tissue-Resident Memory T Cells, Skin, Mucosal Immunity, HPV, Cancer, CXCR3

Organism: Human

Tissue: Skin

Pathological State: HIV Infection

307
CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c. 1085 Genotypes

YM Yeh, PC Lin, WC Su, MR Shen

International Journal of Molecular Sciences (MDPI) Taiwan, 22 November 2021

Oncology

Key words: Colony-Stimulating Factor 1 Receptor, Genetic Variant, CD40, IL-2 Expression, Colorectal Cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

308
BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression

Q Wu, F Liu, M Ge, KV Laster, L Wei, R Du, M Jiang, J Zhang, Y Zhi, G Jin, S Zhao, DJ Kim, Z Dong, K Liu

Oncogene (Nature) China, 19 November 2021

Oncology

Key words: Oncogenes, Transcription

Organism: Human

Cell Line: KYSE450 cells

309
Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca2+ …

R Wang, M Wang, B Liu, H Xu, J Ye, X Sun, G Sun

Biomedicine & Pharmacotherapy (Elsevier) China, 17 November 2021

Cardiology

Key words: calenduloside E, myocardial ischemia-reperfusion injury, L-type Ca2+ channels, BAG3, calcium overload, autophagy

Organism: Rat

Tissue: Heart

Pathological State: Myocardial ischemia

310
Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy

M Gao, Y Chen, C Wu

Bioengineered (Taylor & Francis) China, 16 November 2021

Nanomedicine, Oncology

Key words: Malignant Glioma, Doxorubicin-Loaded Nanoparticles, Chemosensitization, Tumor Chemotherapy, Size-Dependent

Organism: Mouse

Tissue: Heart, Kidney, Liver, Lung, Spleen

Pathological State: Cancer

311
Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells

KC Wei, YC Lin, CH Chen, YH Chu, CY Huang, WC Liao, CH Liu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, 15 November 2021

Oncology

Key words: Fucosyltransferase 8, Glioma, HGF, MET, EGFR

Organism: Human

Tissue: Brain

Pathological State: Cancer

312
HSBP1 Is a Novel Interactor of FIP200 and ATG13 That Promotes Autophagy Initiation and Picornavirus Replication

M Mauthe, N Dinesh Kumar, P Verlhac, N van de Beek, F Reggiori

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) The Netherlands, 15 November 2021

Virology

Key words: Autophagy, Infection, ULK Kinase Complex, EMCV, CVB3, EV71

Organism: Human

Cell Line: U2OS cells 

313
Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

LC Wang, WY Wei, PC Ho, PY Wu, YP Chu, KJ Tsai

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 12 November 2021

Neuroscience

Key words: Cortical Electrical Stimulation, Neuromodulation, Ischemic Stroke, BDNF, PI3K – PKB/Akt Signaling Pathway

Organism: Rat

Tissue: Brain

Pathological State: Stroke

314
TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma

EY Lee, M Kim, BK Choi, DH Kim, I Choi, HJ You

Molecules and Cells (Korean Society for Molecular and Cellular Biology) South Korea, 12 November 2021

Oncology

Key words: cytokines, leiomyosarcoma, tjp1, tumor microenvironment

Organism: Mouse

Tissue: Xenograft Tumor, Esophagus

Pathological State: Cancer

315
Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

AE Hinman, C Jani, SC Pringle, WR Zhang, N Jain, AJ Martinot, AK Barczak

eLife (eLife Sciences Publications) USA, 10 November 2021

Immunology, Microbiology

Organism: Mouse

Tissue: Lung

Pathological State: Tuberculosis

316
Dopamine D2 receptor regulates cortical synaptic pruning in rodents

YQ Zhang, WP Lin, LP Huang, B Zhao, CC Zhang, DM Yin

Nature Communications (Nature) China, 08 November 2021

Neuroscience

Key words: Diseases of The Nervous System, Molecular Neuroscience, Spine Regulation and Structure, Synaptic Development

Organism: Rat

Tissue: Brain

317
Donor Bone Marrow Derived Macrophage Engraftment into the Central Nervous System of Allogeneic Transplant Patients

AM Loeb, SS Pattwell, A Bedalov, S Meshinchi, KR Loeb

Blood (ASH Publications) USA, 05 November 2021

Hematology

Organism: Human

Tissue: Bone Marrow

Pathological State: Allogeneic Transplantation

318
IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1

WJ Wu, SH Wang, CC Wu, YA Su, CY Chiang, CH Lai, TH Wang, TL Cheng, JY Kuo, TC Hsu, TH Lin, YJ Lee

International Journal of Molecular Sciences (MDPI) Taiwan, 05 November 2021

Reproductive Medicine

Key words: IL-4, IL-13, Mammary Glands, Cell Proliferation, STAT6, IRS Protein

Organism: Human

Cell Line: Mammary epithelial cells

319
Cholesterol-lowering Intervention Decreases mTOR Complex 2 Signaling and Enhanced Antitumor Immunity

Y Wang, S You, S Su, A Yeon, E Lo, S Kim, J Mohler, MR Freeman, HL Kim

Clinical Cancer Research (AACR) USA, 02 November 2021

Oncology

Organism: Human

Tissue: Prostate

Pathological State: Cancer

320
Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

RJ Ni, YM Shu, T Li, JN Zhou

Frontiers in Neuroanatomy (Frontiers Media S.A.) China, 02 November 2021

Neuroscience

Key words: Caudate Nucleus, Putamen, Accumbens Nucleus, Thalamus, Neural Circuits

Organism: Tree Shrew

Tissue: Brain

321
Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals

S Fischer, E Nasyrov, M Brosien, KT Preissner, HM Marti, R Kunze

Journal of Neuroinflammation (BMC) Germany, 02 November 2021

Neuroscience

Key words: Extracellular RNA, Astrocyte, Inflammation, Stroke, Ischemia/Reperfusion, PAMP, DAMP, TLR

Organism: Mouse

Tissue: Brain

322
Expression of Vascular Cell Adhesion Molecule-1 in Peripheral Artery Disease is Enriched in Patients with Advanced Kidney Disease

PT Lee, IC Liao, CH Lee, LW Hsu, PY Liu

Acta Cardiologica Sinica (Taiwan Society of Cardiology) Taiwan, 01 November 2021

Cardiology

Key words: Chronic Kidney Disease, Hemodialysis

Organism: Human

Tissue: Kidney

Pathological State: Vascular Disease, Kidney Disease

323
SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway

CY Kuo, YC Chang, MN Chien,

Endocrine-Related Cancer (Society for Endocrinology) Taiwan, 01 November 2021

Oncology

Key words: SREBP1, Invasion, Thyroid Cancer, Lipid Metabolism

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

324
SPION NANOPARTICLES IN VITRO AND IN VIVOTESTING FOR ANTIMELANOMA DRUG RELEASE INTO TUMORS

M Doni, HF Oancea, HRC Fierăscu

The International Symposium PRIOrities of CHEMistry for a sustainable development (ICECHIM) Romania, 29 October 2021

Oncology, Nanomedicine

Key words: melanoma cells, syngeneic melanoma mouse model, drug delivery, IHC, RT-qPCR

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

325
Spatiotemporal Protein Expression Profiles of QSOX1 in the Murine Uterus, Placenta, and Embryo during Pregnancy

HS Lin, RKK Lee, TH Yang, HW Fang, SH Li

Applied Sciences (MDPI) Taiwan, 29 October 2021

Reproductive Medicine

Key words: Quiescin Sulfhydryl Oxidase 1, Uterus, Placenta, Embryo, Maternal-Fetal Interface, Tissue Distribution, Pregnancy

Organism: Mouse

Tissue: Uterus, Placenta, Embryo

Pathological State: Pregnancy

326
Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer

BL Horton, DM Morgan, N Momin, M Zagorulya, E Torres-Mejia, V Bhandarkar, KD Wittrup, JC Love, S Spranger

Science Immunology (Science) USA, 29 October 2021

Oncology, Immunology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

327
Carboxypeptidase N1 is anticipated to be a synergy metrics for chemotherapy effectiveness and prognostic significance in invasive breast cancer

YY Fan, CH Liu, AL Wu, HC Chen, YJ Hsueh, KJ Chen, CC Lai, CY Huang, WC Wu

Cancer Cell International (Springer) China, 28 October 2021

Oncology

Key words: Carboxypeptidase N1, CA153, Chemotherapeutic Efficacy, Prognosis, Invasive Breast Cancer

Organism: Human

Tissue: Breast

Pathological State: Cancer

328
Increased osteogenic activity of dynamic cultured composite bone scaffolds: Characterization and in vitro study

ML Mueller, MP Ottensmeyer, JR Thamm, R Schmelzeisen, MJ Troulis, FPS Guastaldi

Journal of Oral and Maxillofacial Surgery (Elsevier) USA, Germany, 27 October 2021

Osteology

Key words: Scaffolds, Bone Tissue Engineering, Calcium Phosphate, 3D Printing, ALP

Organism: Human

Cell Line: pBMSCs

329
Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer

PF Yueh, YH Lee, I Chiang, WT Chen, KL Lan, CH Chen, FT Hsu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, USA, 26 October 2021

Oncology

Key words: Imipramine, Non-Small Cell Lung Cancer (NSCLC), EGFR - Epidermal Growth Factor Receptor, PKC-δ-Protein Kinase C Delta, NF-κB – Nuclear Factor Kappa B

Organism: Mouse

Tissue: Xenograft Tumor, Lung, Liver

Pathological State: Cancer

330
The prognostic value of TCF1+ CD8+ T in primary small cell carcinoma of the esophagus

L Ma, L Sun, K Zhao, Z Dong, Z Huang, X Meng

Cancer Science (Japanese Cancer Association) China, 25 October 2021

Oncology

Key words: prognosis, PSCCE, stem‐like, TCF1, tumor microenvironment

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

331
Metabolic memory underlying minimal residual disease in breast cancer

K Radic Shechter, E Kafkia, K Zirngibl, S Gawrzak, A Alladin, D Machado, C Lüchtenborg, DC Sevin, B Brügger, KR Patil, M Jechlinger

Molecular Systems Biology (EMBO press) Germany, UK, 25 October 2021

Oncology

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

332
Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction

LJ Renshall, F Beards, A Evangelinos, SL Greenwood, P Brownbill, A Stevens, CP Sibley, JD Aplin, ED Johnstone, T Teesalu, LK Harris

Pharmaceutics (MDPI) UK, USA, 25 October 2021

Reproductive Medicine

Key words: Placenta, Pregnancy, Fetal Growth Restriction, LLiposomes, Epidermal Growth Factor

Organism: Human

Tissue: Placenta

333
Cardiac Fibrosis Is a Risk Factor for Severe COVID-19

J Mustroph, J Hupf, MJ Baier, K Evert, C Brochhausen, K Broeker, C Meindl, B Seither, C Jungbauer, M Evert, LS Maier, S Wagner

Frontiers in Immunology (Frontiers Media S.A.) Germany, 22 October 2021

SARS-CoV-2

Key words: SARS-CoV-2, COVID-19, Fibrosis, Heart, TGF-β1, NRP-1

Organism: Human

Tissue: Heart

Pathological State: COVID-19

334
Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist

H Mei, Z Zha, W Wang, Y Xie, Y Huang, W Li, D Wei, X Zhang, J Qu, J Liu

Genome Biology (BMC) China, 22 October 2021

Genetics

Key words: CRISPR, Genome-wide screen, Surfaceome screen, Rhinovirus, OLFML3

Organism: Human

Pathological State: Rhinovirus Infection

Cell Line: HeLa cells

335
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

C Shen, R Li, R Negro, J Cheng, SM Vora, TM Fu, A Wang, K He, L Andreeva, P Gao, Z Tian, RA Flavell, S Zhu, H Wu

CELL (Cell Press) USA, China, Italy, 21 October 2021

Immunology, Virology

Key words: NLRP6, dsRNA, Liquid-Liquid Phase Separation, LLPS, Inflammasome, MHV, RV, IDRs

Organism: Mouse

Tissue: Liver

336
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

C Vinel, G Rosser, L Guglielmi, M Constantinou, N Pomella, X Zhang, JR Boot, TA Jones, TO Millner, AA Dumas, V Rakyan, J Rees, JL Thompson, J Vuononvirta, S Nadkarni, TE Assan, N Aley, YY Lin, P Liu, S Nelander, D Sheer, CLR Merry F Marelli-Berg, S Brandner, S Marino

Nature Communications (Nature) UK, Hong Kong, Sweden, 21 October 2021

Oncology

Key words: CNS Cancer, Reprogramming

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

337
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements

SM Zhang, WL Cai, X Liu, D Thakral, J Luo, LH Chan, MK McGeary, E Song, KRM Blenman, G Micevic, S Jessel, Y Zhang, M Yin, CJ Booth, LB Jilaveanu, W Damsky, M Sznol, HM Kluger, A Iwasaki, MW Bosenberg, Q Yan

Nature (Nature) USA, China, 20 October 2021

Oncology

Key words: Epigenetics, Melanoma

Organism: Mouse

Tissue: Allograft Tumor, Skin

Pathological State: Cancer

338
A Recurrent STAT5BN642H Driver Mutation in Feline Alimentary T Cell Lymphoma

M Kieslinger, A Swoboda, N Kramer, P Freund, B Pratscher, HA Neubauer, R Steinborn, B Wolfesberer, A Fuchs-Baumgartinger, R Moriggl, IA Burener

Cancers (MDPI) Austria, 19 October 2021

Oncology

Key words: STAT5B, driver mutation, feline alimentary lymphoma, STAT3

Organism: Cat

Tissue: Lymphoid Tissue

Pathological State: Cancer

339
Hippocampal and thalamic afferents form distinct synaptic microcircuits in the mouse infralimbic frontal cortex

K Graham, N Spruston, EB Bloss

Cell Reports (Cell Press) USA, 19 October 2021

Neuroscience

Key words: Frontal Cortex, circuit, Synapse, Interneuron, Projection neuron, rabies tracing, hippocampus, thalamus

Organism: Mouse

Tissue: Brain

340
Autophagy Upregulates miR-449a Expression to Suppress Progression of Colorectal Cancer

SH Lan, SC Lin, WC Wang, YC Yang, JC Lee, PW Lin, ML Chu, KY Lan, R Zuchini, HS Liu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, 19 October 2021

Oncology

Key words: autophagy, miR-449a, FoxO1, colorectal cancer, tumorigenesis

Organism: Human

Tissue: Colon

Pathological State: Cancer

341
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis

F Klemm, A Möckl, A Salamero-Boix, T Alekseeva, A Schäffer, M Schulz, K Niesel, RR Maas, M Groth, BT Elie, RL Bowman, ME Hegi, RT Daniel, PS Zeiner, J Zinke, PN Harter, KH Plate, JA Joyce, L Sevenich

Nature Cancer (Nature) Switzerland, Germany, USA, 18 October 2021

Oncology

Key words: Cancer, Cancer microenvironment, Cancer therapeutic resistance, Metastasis

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

342
Recent progress in cytometric technologies and their applications in ecotoxicology and environmental risk assessment

D Wlodkowic, A Czerw, B Karakiewicz, A Deptala

Cytometry Part A (Wiley) Australia, Poland, 15 October 2021

Toxicology

343
An Integrated Bile Acids Profile Determination by UHPLC-MS/MS to Identify the Effect of Bile Acids Supplement in High Plant Protein Diet on Common Carp (Cyprinus carpio)

X Wei, T Yao, FN Fall, M Xue, X Liang, J Wang, W Du, X Gu

Foods (MDPI) China, 15 October 2021

Gastroenterology

Key words: Bile Acids, Common Carp, High Plant Protein Diet, Hepatopancreas, Glycogen Accumulation, UHPLC-MS/MS

Organism: Common Carp

Tissue: Hepatopancreas

344
LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure

CT Su, TM Jao, Z Urban, YJ Huang, DHW See, YC Tsai, WC Lin, JW Huang

Cell Death & Disease (Nature) Taiwan, 13 October 2021

Nephrology

Key words: Cell signalling, Pathogenesis

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Fibrosis

345
Siglec-15 Is an Immune Suppressor and Potential Target for Immunotherapy in the Pre-Metastatic Lymph Node of Colorectal Cancer

H Du, J Tang, X Li, X Wang, L Wu, R Zhang, P Hu, Y Yang

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 13 October 2021

Oncology

Key words: Pre-Metastatic Niche, Lymph Nodes, Colorectal Cancer, Immunosuppressive, SIGLEC15

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

346
Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation

J Strobl, LM Gail, L Kleissl, RV Pandey, V Smejkal, J Huber, V Puxkandl, L Unterluggauer, R Dindelmaier-Hovorka, D Atzmüller, T Krausgruber, C Bock, P Wohlfarth, W Rabitsch, G Stary

Journal of Experimental Medicine (Rockefeller University Press) Austria, 13 October 2021

Immunology

Organism: Human

Cell Line: Keratinocytes

347
Sexual dimorphism in the bed nucleus of the stria terminalis, medial preoptic area and suprachiasmatic nucleus in male and female tree shrews

RJ Ni, YM Shu, PH Luo, JN Zhou

Journal of Anatomy (Wiley) China, 12 October 2021

Reproductive Medicine

Organism: Tree Shrew

Tissue: Brain

348
Changes in expressions of spermatogenic marker genes and spermatogenic cell population caused by stress

P Tian, Z Zhao, Y Fan, N Cui, B Shi, G Hao

Frontiers in Endocrinology (Frontiers Media S.A.) China, 11 October 2021

Reproductive Medicine

Key words: Stress, Testis, Spermatogenesis, Gene, RNA Sequencing

Organism: Rat

Tissue: Testis

349
Glucose/Glutathione Co-triggered Tumor Hypoxia Relief and Chemodynamic Therapy to Enhance Photothermal Therapy in Bladder Cancer

WH Chen, KJ Yu, JW Jhou, HH Pang, WH Wenig, WS Lin, HW Yang

ACS Applied Bio Materials (ACS Publications) Taiwan, 07 October 2021

Oncology, Pharmacology

Key words: Photothermal Therapy, Chemodynamic Therapy, Manganese Dioxide (MnO2), Tumor Hypoxia, Bladder Cancer

Organism: Mouse

Tissue: Bladder

Pathological State: Cancer

350
Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs

L Johnson Chacko, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudas, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fischer, A Zine

International Journal of Molecular Sciences (MDPI) USA, France, UK, Canada, 07 October 2021

Genetics

Key words: Human Induced Pluripotent Stem Cells, Otic Sensory Progenitors, Gene Expression Analysis, Extracellular Matrix, Integrins, Human Fetal Inner Ear

Organism: Human

Tissue: Bone

351
Irreversible depletion of intestinal CD4+ T-cells is associated with T-cell activation during chronic HIV infection

OE Asowata, A Singh, A Ngoepe, N Herbert, R Faradoos, K Reddy, Y Zuingu, F Nene, N Mthabela, D Ramjit, K Govender, T Ndung'u, JZ Porterfield, JH Adamson, FG Madela, VT Manzini, F Anderson, A Leslie, HN Kløverpris

JCI Insight (American Society of Clinical Investigation) South Africa, Denmark, UK, Germany, USA, 07 October 2021

Immunology, Virology

Organism: Human

Tissue: Small Intestine

Pathological State: HIV Infection

352
Characterizing the host response to rhPDGF‐BB in a rat spinal arthrodesis model

JT Yamaguchi, JA Weiner, S Minardi, AC Greene, DJ Ellenbogen, MJ Hallman, VP Shah, KM Weisz, S Jeong, T Nandurkar, C Yun, WK Hsu, EL Hsu

JOR Spine (Wiley) USA, 07 October 2021

Osteology

Organism: Mouse

Tissue: Bone

353
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

B Wang, L Wang, NS Gasek, Y Zhou, T Kim, C Guo, ER Jellison, L Haynes, S Yadav, T Tchkonia, GA Kuchei, JL Kirkland, M Xu

Nature Aging (Nature) USA, China, 07 October 2021

Aging

Key words: Ageing, Animal biotechnology, Senescence

354
Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

H He, Q Liao, C Zhao, C Zhu, M Feng, Z Liu, L Jiang, L Zhang, X Ding, M Yuan, X Zhang, J Xu

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 06 October 2021

Oncology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

355
Landscape of prognostic signatures and immunogenomics of the AXL/GAS6 axis in renal cell carcinoma

K Hakozaki, N Tanaka, K Takamatsu, R Takashi, Y Yasumizu, S Mikami, T Shinojima, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, R Mizuno, M Oya

British Journal of Cancer (Nature) Japan, 05 October 2021

Oncology

Key words: Renal Cell Carcinoma, Tumour Biomarkers

Organism: Human

Tissue: Kidney

Pathological State: Cancer

356
NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression

J Liang, W Sun, H Song, C Wang, Q Li, C Li, D Wie, Y Zhao, C Li, H Zhang

Epigenomics (Future Medicine) China, 05 October 2021

Oncology, Pharmacology

Key words: Epithelial–Mesenchymal Transition, NOL6, Nucleolar Protein, Tumorigenesis, TWIST1

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

357
Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis

NS Dey, S Senaratne, V Somaratne, NP Madarasinghe, B Seneviratne, S Forrester, M Montes de Oca, L Capos Reis, S Moulik, PB Walrad, M Chatterjee, H Goto, R Wickremasinghe, D Lagos, PM Kaye, S Ranasinghe

The Journal of Clinical Investigation (American Society of Clinical Investigation) UK, Sri Lanka, Brazil, India, 05 October 2021

Immunology, Parasitology

Key words: Immunology, Infectious Disease

Organism: Human

Tissue: Skin

Pathological State: Leishmaniasis, Dermal lesions

358
Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model

MK Chiang, PY Hsiao, YY Liu, HL Tang, CS Chiou, MC Lu, YC Lai

Gut Microbes (Taylor & Francis) Taiwan, 04 October 2021

Oncology, Microbiology

Key words: Klebsiella Pneumoniae, ST11, Colorectal Tumorigenesis, IL-10, M2 Macrophages

Organism: Mouse

Tissue: Colon

Pathological State: Klebsiella Infection, Cancer

359
Epstein-Barr Virus Promotes Tumor Angiogenesis by Activating STIM1-Dependent Ca2+ Signaling in Nasopharyngeal Carcinoma

J Ye, J Wei, Y Luo, Y Deng, T Que, X Zhang, F Liu, J Zhang, X Luo

Pathogens (MDPI) China, 03 October 2021

Oncology, Virology

Key words: Epstein-Barr Virus, Stromal Interaction Molecule 1, Tumor Angiogenesis, Nasopharyngeal Carcinoma

Organism: Human

Tissue: Nasopharynx

Pathological State: Cancer

360
Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer's Disease in nonhuman primates

F Yue, S Feng, C Lu, T Zhang, G Tao, J Liu, C Yue, N Jing

iScience (Cell Press) China, 30 September 2021

Neuroscience

Key words: Alzheimer’s Disease, Non-Human Primate, Aβ Oligomers, Aβ Plaques, Tau Tangles, Animal Model

Organism: Monkey

Tissue: Brain

Pathological State: Alzheimer's Disease

361
Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer

LE Sima, S Chen, H Cardenas, G Zhao, Y Wang, C Ivan, H Huang, B Zhang, D Matei

Journal for ImmunoTherapy of Cancer (BMJ Journals) USA, Romania, 30 September 2021

Oncology

Organism: Mouse

Tissue: Ovaries

Pathological State: Cancer

362
Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice

MMT Islam, D Tarnowski, M Zhang, M Trum, S Lebek, J Mustroph, H Daniel, J Moellencamp, S Pabel, S Sossalla, A El-Armouche, VO Nikolaev, AM Shah, P Eaton, LS Maier, CM Sag, S Wagner

Journal of the American Heart Association (AHA Journals) Germany, Bangladesh, UK, 29 September 2021

Cardiology

Key words: Pressure Overload, Redox, Protein Kinase A, Heart Failure

Organism: Mouse

Tissue: Heart

Pathological State: Heart Failure

363
Turning up the heat on non-immunoreactive tumors: pyroptosis influences the tumor immune microenvironment in bladder cancer

X Chen, H Chen, H Yao, K Zhao, Y Zhang, D He, Y Zhu, Y Cheng, R Liu, R Xu, K Cao

Oncogene (Nature) China, Sweden, 29 September 2021

Oncology

Key words: Cancer Microenvironment, Cell Death and Immune Response, Predictive Markers

Organism: Human

Tissue: Bladder

Pathological State: Cancer

364
Adaptive metabolic responses in a thermostabilized environment: Transgenerational trade-off implications from tropical tilapia

MC Wang, MT Hsu, CC Lin, SC Hsu, RD Chen, JR Lee, YL Chou, HP Tseng, F Furukawa, SPL Hwang, PP Hwang, YC Tseng

Science of The Total Environment (Elsevier) Taiwan, Japan, 29 September 2021

Genetics, Ecology

Key words: Thermal Variance, Cold Exposure, Transgenerational Plasticity, Metabolism, Tropical Fish

Organism: Fish

Tissue: Liver

365
Human Milk Oligosaccharides alleviate stress-induced visceral hypersensitivity and associated microbiota dysbiosis

L Ferrier, H Eutamène, L Siegwald, AM Marquard, V Tondereau, J Chevalier, GE Jacot, L Favre, V Theodorou, M Vicario, A Rytz, G Bergonzelli, CL Garcia-Rodenas

The Journal of Nutritional Biochemistry (Elsevier) Switzerland, France, Denmark, 25 September 2021

Gastroenterology

Key words: HMOs, Abdominal Pain, Chronic Psychological Stress, Antibiotics, Microbiome, Metagenomic

Organism: Mouse

Tissue: Colon

366
CD8+ T effector and immune checkpoint signatures predict prognosis and responsiveness to immunotherapy in bladder cancer

X Chen, R Xu, D He, Y Zhang, H Chen, Y Zhu, Y Cheng, R Liu, R Zhu, L Gong, M Xiao, Z Wang, L Deng, K Cao

Oncogene (Nature) China, 22 September 2021

Oncology

Key words: Bladder Cancer, Immunotherapy

Organism: Human

Tissue: Bladder

Pathological State: Cancer

367
Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study

HR Jang, M Kim, S Hong, K Lee, MY Park, KE Yang, CJ Lee, J Jeon, KW Lee, JE Lee, JB Park, K Kim, GY Kwon, YG Kim, DJ Kim, W Huh

Scientific Reports (Nature) South Korea, 22 September 2021

Nephrology

Key words: Biomarkers, Kidney Diseases, Predictive Markers, Renal Replacement Therapy

Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

368
Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

P Talarska, M Boruczkowski, J Żurawski

Nanomaterials (MDPI) Poland, 21 September 2021

Nanomedicine

Key words: Silver Nanoparticles, Gold Nanoparticles, Nanotoxicology, Nanoparticle Interactions, Nanoparticle Applications

Organism: Mouse

Tissue: Brain

369
Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy

K Takamatsu, N Tanaka, K Hakozaki, R Takahashi, Y Teranishi, T Murakami, R Kufukihara, N Niwa, S Mikami, T Shinojima, T Sasaki, Y Sato, H Kume, S Ogawa, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, K Sawada, T Imamura, R Mizuno, M Oya

Nature Communications (Nature) Japan, 20 September 2021

Oncology

Key words: Cancer Immunotherapy, Cancer Microenvironment, Predictive Markers, Renal Cell Carcinoma, Tumour Biomarkers

Organism: Human

Tissue: Kidney

Pathological State: Cancer

370
PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression

XY Qin, QH Shan, H Fang, Y Wang, P Chen, ZQ Xiong, DF Swaab, JN Zhou

Acta Neuropathologica (Springer) China, The Netherlands, 18 September 2021

Neuroscience

Key words: Depression, Paraventricular Nucleus, PSD-93, Corticotropin-Releasing Hormone, Synaptic Regulation

Organism: Mouse

Tissue: Brain

Pathological State: Depression

371
Interferon Gamma-Induced Interferon Regulatory Factor 1 Activates Transcription of HHLA2 and Induces Immune Escape of Hepatocellular Carcinoma Cells

R Wang, H Guo, X Tang, T Zhang, Y Liu, C Zhang, H Yu, Y Li

Inflammation (Springer) China, 18 September 2021

Oncology, Immunology

Key words: Hepatocellular Carcinoma, HHLA2, Tumor-Associated Macrophages, PD-L1, Immune Escape, IFNG, IFR1

Organism: Human

Tissue: Liver

Pathological State: Cancer

372
Experimental nerve transfer model in the neonatal rat

ME Sporer, M Aman, KD Bergmeister, D Depisch, KM Scheuba, E Unger, BK Podesser, OC Aszmann

Neural Regeneration Research (Wolters Kluwer) Austria, 17 September 2021

Regenerative Medicine, Neuroscience

Key words: brachial plexus birth injury, experimental rat model, extremity reconstruction, methodological paper, neonatal rat, nerve reconstruction, nerve regeneration, nerve transfer, neural plasticity, peripheral nerve surgery

Organism: Rat

Tissue: Muscle

373
Multiomic analysis reveals comprehensive tumor heterogeneity and distinct immune subtypes in multifocal intrahepatic cholangiocarcinoma

SL Chen, Y Xie, Y Cai, H Hu, M He, L Liu, C Liao, Y Wang, J Wang, X Ren, Q Zeng, H Peng, S Shen, SQ Li, D Li, J Lai, B Peng, J Ren, M Kuang, S Peng

Clinical Cancer Research (AACR) China, 15 September 2021

Oncology

Key words: Multifocal Intrahepatic Cholangiocarcinoma, Heterogeneity, Clonal Evolution, Immune Microenvironment, Immunotherapy

Organism: Human

Tissue: Liver

Pathological State: Cancer

374
Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress

BG Durgin, KC Wood, SA Hahn, B McMahon, JJ Baust, AC Straub

Journal of Molecular and Cellular Cardiology (Elsevier) USA, 15 September 2021

Cardiology

Key words: Smooth Muscle Cell, Redox, Hypoxia, Nitric Oxide, Hypertrophy, Soluble Guanylyl Cyclase

Organism: Mouse

Tissue: Heart

Pathological State: Cardiac Fibrosis

375
LncRNA PVT1 knockdown ameliorates myocardial ischemia reperfusion damage via suppressing gasdermin D-mediated pyroptosis in cardiomyocytes

C Li, H Song, C Chen, S Chen, Q Zhang, D Liu, J Li, H Dong, Y Wu, Y Liu

Frontiers in Cardiovascular Medicine (Frontiers Media S.A.) China, 14 September 2021

Cardiology

Key words: lncRNA, PVT1, Myocardial Ischemia Reperfusion, Pyroptosis, Gasdermin D

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Ischemia

376
Estimating the time of skeletal muscle contusion based on the spatial distribution of neutrophils: a practical approach to forensic problems

Q Du, L Wang, D Li, J Niu, X Zhang, J Sun

International Journal of Legal Medicine (Springer) China, 13 September 2021

Biological Methods

Key words: Estimating Injury Time, Spatial Distribution, Immunohistochemical, Skeletal Muscle Contusion, Fisher Discriminant Analysis

Organism: Rat

Tissue: Bone

377
Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against …

Y Ni, BC Hu, GH Wu, ZQ Shao, Y Zheng, R Zhang, J Jin, J Hong, XH Yang, RH Sun, JQ Liu, SJ Mo

Theranostics (Ivyspring International Publisher) China, 13 September 2021

Immunology

Key words: Neutrophil extracellular traps, Fibroblast growth factor-inducible molecule 14, Macrophages, Homeobox protein Hox-A5, Septic acute kidney injury

Organism: Mouse

Tissue: Kidney

Pathological State: Sepsis

378
N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation

J Li, X Hu, T Luo, Y Lu, Y Feng, H Zhang, D Liu, X Fan, Y Wang, L Jiang, Y Wang, X Hao, T Shi, Z Wang

European Journal of Medicinal Chemistry (Elsevier) China, 10 September 2021

Biological Materials

Key words: Glioma, N-2-(Phenylamino) Benzamide, Topoisomerase I Inhibitor, COX-2 Inhibitor, Pseudocycle

Organism: Rat

Tissue: Brain

Pathological State: Cancer

379
Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

S Niu, W Shi, Y Li, S Yi, Y Li, X Liu, B Cong, G He

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 08 September 2021

Neuroscience

Organism: Rat

Tissue: Brain

380
Case Study of Noni Extract in Men with Very Low-Risk or Low-Risk Prostate Cancer

Y Hirasawa, I Pagano, JH Pharm, Y Sasaki, K Murakami, CJ Rosser, H Furuya

Hawai 'i Journal of Health & Social Welfare (hawaiijournalhealth.org) USA, 08 September 2021

Oncology

Key words: Prostate Cancer, Active Surveillance, Noni

Organism: Human

Tissue: Prostate

Pathological State: Cancer

381
Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile

H Rossiter, D Copic, M Direder, F Gruber, S Zoratto, M Marchetti-Deschmann, C Kremslehner, M Sochorova, IM Nagelreiter, V Mlitz, M Buchberger, B Lengauer, B Golabi, S Sukseree, M Mildner, L Eckhart, E Tschachler

Autophagy (Taylor & Francis) Austria, 07 September 2021

Aging

Key words: Autophagosomes, GFP-LC3, Lipid Droplets, Perilipin, Sebocytes

Organism: Mouse

Tissue: Skin

382
Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia

DR Collins, JM Urbach, ZJ Racenet, U Arshad, KA Power, RM Newman, GH Mylvaganam, NL Ly, X Lian, A Rull, Y Rassadkina, AG Yanez, MJ Peluso, SG Deeks, F Vidal, M Lichterfeld, XG Yu, GD Gaiha, TM Allen, BD Walker

Immunity (Cell Press) USA, Spain, 07 September 2021

Virology, Immunology

Key words: Human Immunology, HIV Control, CD8+ T Cell Dysfunction

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

383
Reciprocal regulation of endothelial–mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease

B Vanchin, M Sol, RAF Gjaltema, M Brinker, B Kiers, AC Pereira, MC Harmsen, JAJ Moonen, G Krenning

Scientific Reports (Nature) The Netherlands, Mongolia, Brazil, 07 September 2021

Cardiology

Key words: Cell Signalling, Epigenetics, Mechanisms of Disease, Non-Coding Rnas, Pathogenesis, Vascular Diseases

Organism: Human

Pathological State: Coronary artery disease

Cell Line: Endothelial cells

384
Elevated β-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease

L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen

Brain, Behavior, and Immunity (Elsevier) China, 06 September 2021

Neuroscience

Key words: β -Secretase, CD4+ T Cell, PGE2 Signalling, Alzheimer’s Disease, Neuroinflammation, T Cell Receptor (TCR)

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

385
PAC1 receptor mediates electroacupuncture-induced neuro and immune protection during cisplatin chemotherapy

S Li, J Huang, Y Guo, J Wang, S Lu, B Wang, Y Gong, S Qin, S Zhao, S Wang, Y Liu, Y Fang, Y Guo, Z Xu, L Ulloa

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 06 September 2021

Oncology, Pharmacology

Key words: Neuromodulation, Chemotherapy, Immunosuppression, Hematopoiesis, Neurotoxic, Electroacupuncture

Organism: Mouse

Tissue: Bone Marrow

Pathological State: Cancer

386
Decompartmentalisation as a simple color manipulation of plant-based marbling meat alternatives

S Ong, L Loo, M Pang, R Tan, Y Teng, X Lou, SK Chin,MY Naik, H Yu

Biomaterials (Elsevier) Singapore, 03 September 2021

Biological Materials, Tissue Engineering

Key words: Cell-Based Meat, Edible Scaffold, Meat Marbling, Cellulose, Polyphenol, Organoleptic

Organism: Jackfruit

387
Single‐cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer

H Lai, X Cheng, Q Liu, W Luo, M Liu, M Zhang, J Miao, Z Ji, GN Lin, W Song, L Zhang, J Bo, G Yang, J Wang, WQ Gao

International Journal of Cancer (Wiley) China, 03 September 2021

Oncology

Organism: Human

Tissue: Bladder

Pathological State: Cancer

388
Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas

C Gribben, C Lambert, HA Messal, EL Hubber, C Rackham, I Evans, H Heimberg, P Jones, R Sancho, A Behrens

Cell Stem Cell (Cell Press) UK, Belgium, Germany, 02 September 2021

Stem Cell Research

Key words: β Cells, Pancreas, Diabetes, δ Cells, Lineage Tracing, Ngn3, Progenitor, Regeneration

Organism: Mouse

Tissue: Pancreas

Pathological State: Diabetes

389
Nanostructured Lipid Carrier Gel Formulation of Recombinant Human Thrombomodulin Improve Diabetic Wound Healing by Topical Administration

YS Hsueh, YJ Shyong, HC Yu, SJ Jheng, SW Lin, HL Wu, JC Tsai

Pharmaceutics (MDPI) Taiwan, 02 September 2021

Biological Materials

Key words: Nanostructured Lipid Carrier, Protein Drug Delivery, Sustained Release, Chronic Wound Healing, Angiogenesis Factor, Carbopol Gel, Thrombomodulin

Organism: Mouse

Tissue: Skin

390
A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution

H Yang, S Yang, F Fan, Y Li, S Dai, X Zhou, CC Steiner, B Coppedge, C Roos, X Cai, DM Irwin, P Shi

Molecular Biology and Evolution (Oxford Academic) China, USA, Germany, Canada, 01 September 2021

Genetics, Evolution

Key words: Convergent Evolution, Bitter Taste Receptors, Tas2R16, Human, White-Faced Saki, Pithecia Pithecia, Adaptive Evolution

Organism: Human

Cell Line: HEK293 cells

391
Improving Mask R-CNN for Nuclei Instance Segmentation in Hematoxylin & Eosin-Stained Histological Images

B Bancher, A Mahbod, I Ellinger, R Ecker, G Dorffner

Proceedings of Machine Learning Research (PMLR) Austria, 01 September 2021

Machine Learning

Key words: Mask R-CNN, Nuclei Segmentation, Medical Image Analysis, Deep Learning, Computational Pathology

392
Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation

M Rath, A Pitiot, M Kirr, W Fröhlich, B Plosnita, S Schliep, J Bauerschmitz, AS Baur, C Ostalecki

International Journal of Molecular Sciences (MDPI) Germany, UK, Austria, 30 August 2021

Dermatology

Key words: Scar, Dendritic Cells, Tumor Microenvironment, Single-Cell Analysis, Multiplex Imaging, Proteases, Tumor Biology

Organism: Human

Tissue: Skin

Pathological State: Keloid

393
Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury

WZ Wang, X Liu, ZY Yang, YZ Wang, HT Lu

Neural Regeneration Research (Wolters Kluwer) China, 30 August 2021

Neuroscience

Key words: brain-derived neurotrophic factor, diffusion tensor imaging, fractional anisotropy value, global cerebral ischemia/reperfusion injury, hippocampus, TrkB

Organism: Rat

Tissue: Brain

394
Characteristics of Chlamydia suis Ocular Infection in Pigs

C Unterweger, A Inic-Kanada, S Setudeh, C Knecht, S Duerlinger, M Stas, D Vanrompay, C Kiekens, R Steinparzer, W Gerner, A Ladinig, T Barisani-Asenbauer

Pathogens (MDPI) Austria, Belgium, 29 August 2021

Microbiology

Key words: Chlamydia Suis, Piglets, Experimental Conjunctival Infection, Serology, Antibodies, Immunohistochemistry, Lacrimal Gland

Organism: Pig

Tissue: Eye, Lung, Colon, Testis, Kidney

Pathological State: Chlamydia Infection

395
Bone Marrow Remodelling Supports Hematopoiesis in Response to Immune Thrombocytopenia Progression in Mice

OJ Herd, GF Rani, JP Hewitson, K Hogg, AP Stone, N Cooper, DG Kent, PG Genever, IS Hitchcock

Blood Advances (Elsevier) UK, 26 August 2021

Hematology

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Immune thrombocytopenia

396
TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas

E Gonzalez-Buendia, J Zhao, L Wang, S Mukherjee, D Zhang, VA Arrieta, E Feldstein, JR Kane, SJ Kang, C Lee-Chang, A Mahajan, L Chen, R Realubit, C Karan, L Magnuson, C Horbinski, SA Marshall, JN Sarkaria, A Mohyeldin, I Nakano, M Bansal, CD James, DJ Brat, A Ahmed, P Canoll, R Rabadan, A Shilatifard, AM Sonabend

Clinical Cancer Research (AACR) USA, 25 August 2021

Oncology

Organism: Mouse

Tissue: Brain, Xenograft Tumor

Pathological State: Cancer

397
Biocompatible Copper Sulfide Based Nanocomposites for Artery Interventional Chemo-Photothermal Therapy of Orthotropic Hepatocellular Carcinoma

X Li, H Yuan, X Tian, J Tang, L Liu, F Liu

Materials Today Bio (Elsevier) China, 25 August 2021

Nanomedicine

Key words: DOX@BSA-CuS Nanocomposites, NIR-Responsive, Photothermal Ablation, Chemoembolization, MRI Guided Therapy

Organism: Rat

Tissue: Liver

Pathological State: Cancer

398
Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin

R Herzog, JM Sacnun, G González-Mateo, M Bartosova, K Bialas, A Wagner, M Unterwurzacher, IJ Sobieszek, L Daniel-Fischer, K Rusai, L Pascual-Antón, K Kaczirek, A Vychytil, C Peter Schmitt, M López-Cabrera, SL Alper, C Aufricht, K Kratochwill

Science Translational Medicine (AAAS) Austria, Spain, Germany, USA, 25 August 2021

Nephrology

Organism: Human

Tissue: Peritoneum

399
Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma

TH Hung, JT Hung, CE Wu, Y Huang, CW Lee, CT Yeh, YH Chung, FY Lo, LC Lai, JK Tung, J Yu, CN Yeh, AL Yu

Hepatology Communications (Wiley) Taiwan, 24 August 2021

Hepathology, Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

400
Oroxylin A promotes therapeutic efficacy of cisplatin to suppress bladder cancer progression via inducing ferroptosis

Q Tang, J Jiang, J Sun, L Tang, X Zhang

Biochemical and Biophysical Research Communications (Elsevier) China, 21 August 2021

Oncology, Pharmacology

Key words: Bladder Cancer, cDDP, Oroxylin A (OroA), Ferroptosis

Organism: Mouse

Tissue: Bladder

Pathological State: Cancer

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