Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Filter publications

Customer Publications (A total of 2889 papers published)

201
BNIP3 in hypoxia-induced mitophagy: Novel insights and promising target for non-alcoholic fatty liver disease

M Tian, J Hou, Z Liu, Z Li, D Huang, Y Zhang, Y Ma

The International Journal of Biochemistry & Cell Biology (Elsevier) China, 11 January 2024

Hepathology

Key words: BNIP3; Hypoxia; Mitophagy; NAFLD; β-oxidation.

Organism: Mouse

Tissue: Liver

Pathological State: Non-Alcoholic Fatty Liver disease

202
Unraveling the Role of miR-200b-3p in Attention-Deficit/Hyperactivity Disorder (ADHD) and Its Therapeutic Potential in Spontaneously Hypertensive Rats (SHR)

TM Chang, HL Lin, CC Tzang, JA Liang, TC Hsu, BS Tzang

Biomedicines (MDPI) Taiwan, 10 January 2024

Neuropsychiatry

Key words: taurine, attention deficit hyperactivity disorder (ADHD), neuropsychiatric disorder, microRNA (miR)-200b-3p, striatum; spontaneously hypertensive rats (SHR), inflammatory factors, spontaneous alternations

Organism: Rat

Tissue: Brain

203
Effects of Citrus depressa Hayata juice on high-fat diet-induced obesity in HBV transgenic mice

PY Chu, CL Hsu, YA Lin, YC Pan, YH Dai, YC Yu, JC Yang, WL Ma, YJL Chen, CL Lee, YC Wu

Heliyon (Cell Press) Taiwan, 10 January 2024

Nutritional science

Key words: Citrus depressa hayata, Juice, fermentation, Polyphenol, Hesperidin, High-fat diet-induced obesity, HBV, Mice

Organism: Mouse

Tissue: Liver

Pathological State: HBV

204
Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice

X Bai, B Wang, Y Cui, S Tian, Y Zhang, L You, YZ Chang, G Gao

Journal of Neuroinflammation (Springer) China, 09 January 2024

Neuroscience

Key words: Hepcidin, Iron, Alzheimer's disease, Hippocampal neurogenesis, Cognitive dysfunction

Organism: Mouse

Tissue: Brain

205
Amyloid Burden Correlates with Electrocardiographic Findings in Patients with Cardiac Amyloidosis—Insights from Histology and Cardiac Magnetic Resonance Imaging

F Duca, R Rettl, C Kronberger, M Poledniczek, C Binder, D Dalos, M Koschutnik, C Donà, D Beitzke, C Loewe, C Nitsche, C Hengstenberg, R Badr-Eslam, J Kastner, J Bergler-Klein, AA Kammerlander

Journal of Clinical Medicine (MDPI) Austria, 09 January 2024

Cardiology

Key words: cardiac amyloidosis; transthyretin amyloidosis; light chain amyloidosis; electrocardiogram; histology; T1 mapping; extracellular volume; cardiac magnetic resonance imaging

Organism: Human

Tissue: Heart

Pathological State: Cardiac Amyloidosis

206
PD-L1-positive circulating endothelial progenitor cells associated with immune response to PD-1 blockade in patients with head and neck squamous cell carcinoma

NW Su, SH Dai, K Hsu, KM Chang, CC Ko, CW Kao, YF Chang, CG Chen

Cancer Immunology, Immunotherapy (Springer) Taiwan, 04 January 2024

Immunology, Oncology

Key words: PD-1, PD-L1, Head and neck cancer, Circulating endothelial cell, Circulating endothelial progenitor cell

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

207
Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion

R Yan, P Zhang, S Shen, Y Zeng, T Wang, Z Chen, W Ma, J Feng, C Suo, T Zhang, H Wei, Z Jiang, R Chen, S Li, X Zhong, W Jia, L Sun, C Cang, H Zhang, P Gao

Nature Immunology (Nature) China, 04 January 2024

Oncology

Organism: Human, Mouse

Cell Line: HepG2, PLC, HEK293 and HEK293T

208
Knockout of Shcbp1 sensitizes immunotherapy by regulating α‐SMA positive cancer‐associated fibroblasts

Q Gu, Z Ma, Q Wang, Y Dai, W Shi, Z Jiao

Molecular Carcinogenesis (Wiley) China, 03 January 2024

Oncology, Immunology

Key words: breast cancer, CAFs, Erdafitinib, ICT, Shcbp1

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

209
OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB

W Ma, Y Sun, R Yan, P Zhang, S Shen, H Lu, Z Zhou, Z Jiang, L Ye, Q Mao, N Xiong, W Jia, L Sun, P Gao, H Zhan

Molecular Cell (Cell Press) China, 03 January 2024

Oncology

Organism: Human, Mouse

Cell Line: HepG2, HEK293T

210
Applications of Digital Pathology in Cancer: A Comprehensive Review

M Omar, MK Alexanderani, I Valencia, M Loda, L Marchionni

Annual Review of Cancer Biology (Annual Reviews) USA, UK, 02 January 2024

Oncology

Key words: digital pathology, whole-slide imaging, deep learning, artificial intelligence, cancer research, histopathology image analysis

211
Function and mechanism of GBP1 in the development and progression of cervical cancer

S Wang, Y Zhang, X Ma, Y Feng

Journal of Translational Medicine (BMC) China, 02 January 2024

Oncology

Key words: Guanylate binding protein 1 (GBP1), Tumor immunity, Cervical cancer, Alternative splicing (AS), Cancer promotion

Organism: Human

Tissue: Cervix

Pathological State: Cancer

212
Effects of poly (ADP-ribose) polymerase inhibitor treatment on the repair process of ischemic acute kidney injury

J Jeon, K Lee, HR Jang, KE Yang, CJ Lee, H Ahn, WY Park, JE Lee, GY Kwon, YG Kim, W Huh

Scientific Reports (Nature) South Korea, 02 January 2024

Nephrology

Key words: Acute kidney injury, Inflammation

Organism: Mouse

Tissue: Kidney

Pathological State: Ischemia

213
Digitale Pathologie in Österreich

C Schatz, A Qerimi, J Haybaeck

Die Pathologie (Springer) Austria, 01 January 2024

Medical Image Analysis

Key words: Metadata whole slide images, Telepatholgy, AI, Diagnosis, whole slide images

214
Proteomics Analysis to Explore the Resistance Genes of Silkworm to Bombyx mori Nuclear Polyhedrosis Virus

G Ouyang, H Qian, J Sun, R Yang, T Gui, W Wang, Q Liu, A Chen

Genes (MDPI) China, 30 December 2023

Virology

Key words: B. mori, BmNPV, resistance gene, 2-DE, qRT-PCR

Organism: Silkworm

Tissue: Stomach

Pathological State: Viral Infection

215
Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury

CJ Yang, HC Chang, PC Sung, MC Ge, HY Tang, ML Cheng, HT Cheng, HH Chou, CY Lin, WR Lin, YS Lee, SY Hsieh

Cell Reports (Cell Press) Taiwan, 27 December 2023

Hepathology

Organism: Mouse

Tissue: Liver

Pathological State: Acute liver injury

216
In vivo imaging reveals a synchronized correlation among neurotransmitter dynamics during propofol and sevoflurane anesthesia.

GL Qiu, LJ Peng, P Wang, ZL Yang, JQ Zhang, H Liu, XN Zhu, J Rao, XS Liu

Zoological Research (search.ebscohost.com) China, 26 December 2023

Neuroscience

Key words: General anesthesia, Loss of consciousness, In vivo neurotransmitter imaging, Medial prefrontal cortex, Primary visual cortex

217
Electron irradiation of zein protein-loaded nano CaO2/CD for enhancing infectious diabetic wounds with adaptive hydrophobicity-to-hydrophilicity

L Zhou, S Guo, Z Dong, P Liu, W Shi, L Shen, J Yin

Materials Today Advances (Elsevier) China, 23 December 2023

Pharmacology

Key words: Diabetic wound healing, Antibacterial property, Reactive oxygen species, Inflammation suppression, Macrophage polarization, Adaptive hydrophobicity-to-hydrophilicity

Organism: Rat

Tissue: Skin

Pathological State: Diabeties

218
MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

J Chen, Q Zheng, JL Hicks, L Trabzonlu, B Ozbek, , T Jones, AM Vaghasia, TC Larman, R Wang, MC Markowski, SR Denmeade, KJ Pienta, RH Hruban, ES Antonarakis, A Gupta, CV Dang, S Yegnasubramanian, AM De Marzo

JCI insight (The american society for clinical investigation) USA, 22 December 2023

Oncology

Key words: Metabolism, Oncology, Cancer, Mitochondria

Organism: Mouse

Tissue: Prostate

Pathological State: Cancer

219
Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ

X Cai, R Wang, J Zhu, X Li, X Liu, G Ouyang, J Wang, Z Li, C Zhu, H Deng, W Xiao

Cell Reports (Cell Press) China, 20 December 2023

Immunology

Key words: Immunology, FIH, IKKϵ, MAVS, TBK1, TRAF3, hydroxylation, hypoxia, innate immunity, mouse, zebrafish

Organism: Mouse, Zebrafish

Tissue: Lung

Pathological State: Viral Infection

220
Relationship between Aspartame-Induced Cerebral Cortex Injury and Oxidative Stress, Inflammation, Mitochondrial Dysfunction, and Apoptosis in Sprague Dawley Rats

J U-pathi, YC Yeh, CW Chen, EE Owaga, RH Hsieh

Antioxidants (MDPI) Taiwan, Kenya, 19 December 2023

Nutritional science

Key words: aspartame, inflammation, oxidative stress, mitochondrial biogenesis, apoptosis

Organism: Rat

Tissue: Brain

221
Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits

WL Septiana, W Ayudyasari, H Gunardi, JA Pawitan, GM Balachander, H Yu, RD Antarianto

In Vitro Cellular & Developmental Biology - Animal (Springer) Indonesia, Singapore, India, 18 December 2023

Hepathology

Key words: Liver organoid, iPSCs, Hepatocyte-differentiation, Transplant, Liver failure

Organism: Rabbit

Tissue: Kidney

Pathological State: Liver failure

222
Renoprotective effects of extracellular fibroblast specific protein 1 via nuclear factor erythroid 2-related factor-mediated antioxidant activity

N Takahashi, S Yokoi, H Kimura, H Naiki, T Matsusaka, Y Yamamoto, K Nakatani, K Kasuno, M Iwano

Scientific Reports (Nature) Japan, 18 December 2023

Nephrology

Key words: Medical research, Nephrology

Organism: Mouse

Tissue: Brain

223
Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling

Y Wang, M Yao, C Li, K Yang, X Qin, L Xu, S Shi, C Yu, X Meng, C Xie

Experimental Hematology & Oncology (BMC) China, 16 December 2023

Oncology

Key words: KRASG12C, c-Myc, PLK1, LncRNA, ST8SIA6-AS1, Drug resistance

Organism: Human

Pathological State: Cancer

Cell Line: NCI-H358, NCI-H1373, NCI-H23, SW1573, MIA PaCa-2, SW1463

224
Melatonin exhibits partial protective effects against gemcitabine-and cisplatin-induced kidney and reproductive injuries in mice

SC Wang, HC Hsu, YC Chang, CY Yu, CT Liu, WW Sung

Aging (Impact Journals) Taiwan, 14 December 2023

Nephrology, Reproductive Medicine

Key words: melatonin, hormone, testosterone, sperm, chemotherapy

Organism: Mouse

Tissue: Testis, Kidney

225
In silico analyses of pan-squamous cell carcinoma unveiled the immunological implications of MRPL13, which had previously been under-recognized

Y Liang, S He, Y Tan, Q Liu, F Zhao, T Liu, C Huang, X Lu, S Zheng

Heliyon (Cell) China, 14 December 2023

Oncology, Immunology

Key words: MRPL13, Pan-squamous cell carcinoma, Bioinformatics analysis, Prognostic, CD8+ T-cell infiltration

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

226
Egocentric processing of items in spines, dendrites, and somas in the retrosplenial cortex

N Cheng, Q Dong, Z Zhang, L Wang, X Chen, C Wang

Neuron (Cell Press) China, 14 December 2023

Neuroscience

Key words: retrosplenial, egocentric, dendrite, spine, goal, context, landmark

Organism: Mouse

Tissue: Brain

227
Static Magnetic Field Reduces Intracellular ROS Levels and Protects Cells Against Peroxide-Induced Damage: Suggested Roles for Catalase

ECG Frachini, JB Silva, B Fornaciari, MS Baptista, H Ulrich, DFS Petri

Neurotoxicity Research (Springer) Brazil, 14 December 2023

Neuroscience

Key words: External magnetic field, Oxidative stress, Neuroprotection, SH-SY5Y cells, Cell proliferation

Organism: Human

Cell Line: SH-SY5Y

228
ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-Guided Analysis

VA Arrieta, J Duerinck, KB Burdett, KJ Habashy, W Geens, A Gould, JK Schwarze, C Dmello, KS Kim, R Saganty, L Chen, A Moscona, M McCord, C Lee-Chang, CM Horbinski, H Zhang, R Stupp, B Neyns, AM Sonabend

Clinical Cancer Research (AACR) Belgium, USA, Mexico, 13 December 2023

Oncology, Pharmacology

Organism: Human

Tissue: Brain

Pathological State: Cancer

229
Chlamydia suis survival in dust: First insights–A short communication

C Unterweger, M Koch, S Winkler, S Hammer, A Oppeneder, A Ladinig

Research in Veterinary Science (Elsevier) Austria, 13 December 2023

Microbiology

Key words: Chlamydia suis, Pigs, Dust, Transmission, Disinfection, Viability

Pathological State: Chlamydia infection

Cell Line: LLC-MK2 cells (Rhesus monkey kidney cell line)

230
The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development

MF Chen, CC Hu, YH Hsu, YC Lin, KL Chen, SWN Ueng, Y Chang

Bone & Joint Research (The British Editorial Society of Bone & Joint Surgery) Taiwan, 12 December 2023

Osteology

Key words: Osteoarthritis, EDIL3, Chondrocyte, Extracellular matrix, Cartilage, osteoarthritic changes, cartilage tissues, extracellular matrix, chondrocytes, antibodies, interleukin, aggrecan, pro-inflammatory cytokines, OARSI, subchondral bone plate

Organism: Human

Tissue: Bone

Pathological State: Osteoarthritis

231
Differential effects of microRNAs miR‐21, miR‐99 and miR‐145 on lung regeneration and inflammation during recovery from influenza pneumonia

JWJ Ong, KS Tan, JJX Lee, JE Seet, HW Choi, SG Ler, J Gunaratne, T Narasaraju, L-T Sham, V Patzel, VT Chow

Journal of Medical Virology (Wiley Online Library) Singapore, India, UK, 12 December 2023

Pulmonology

Key words: influenza, lung regeneration, microRNAs, miR-21, mi-99a, miR-145, pneumonia, proliferating AT2 cells, RNA sequencing, stem cells

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

232
Corynoline inhibits esophageal squamous cell carcinoma growth via targeting Pim-3

Y Shi, Q Yuan, Y Chen, X Li, Y Zhou, H Zhou, F Peng, Y Jiang, Y Qiao, J Zhao, C Zhang, J Wang, K Liu, Z Dong

Phytomedicine (Elsevier) China, 12 December 2023

Oncology, Pharmacology

Key words: Proviral integration site for maloney murine leukemia virus 3, corynoline, esophageal squamous cell carcinoma, proliferation, apoptosis

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

233
Granzyme K–and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease

R Koga, T Maehara, R Aoyagi, R Munemura, Y Murakami, A Doi, M Kono, H Yamamoto, H Niiro, T Kiyoshima, M Tanabe, T Nakano, Y Matsukuma, M Kawano, JH Stone, S Pillai, S Nakamura, S Kawano

Journal of Allergy and Clinical Immunology (Elsevier) Japan, USA, 11 December 2023

Immunology

Key words: Single-cell RNA sequencing, IgG4-related disease, granzyme K, cytotoxic T cells, fibrosis, amphiregulin, double-negative (DN) B

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's Syndrome

234
Hypoxia is correlated with the tumor immune microenvironment: Potential application of immunotherapy in bladder cancer

H Chen, Y Zhang, X Chen, R Xu, Y Zhu, D He, Y Cheng, Z Wang, X Qing, K Cao

Cancer Medicine (Wiley Online Library) China, 08 December 2023

Oncology, Pharmacology

Key words: bladder cancer, hypoxia, immune checkpoint inhibitorn TLR8, tumor microenviorment

Organism: Human

Cell Line: BLCA T24

235
A breast cancer classification and immune landscape analysis based on cancer stem-cell-related risk panel

H Hu, M Zou, H Hu, Z Hu, L Jiang, D Escobar, H Zhu, W Zhan, T Yan, T Zhang

NPJ Precision Oncology (Nature) China, USA, 08 December 2023

Oncology

Key words: Cancer genomics, Prognostic markers

Organism: Human

Tissue: Breast

Pathological State: Cancer

236
Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis

YY Wang, KH Cheng, AC Hung, S Lo, PY Chen, YC Wu, MF Hou, SSF Yuan

International Journal of Oncology (Spandios Publications) Taiwan, 07 December 2023

Oncology, Molecular Biology

Organism: Human

Tissue: Breast

Pathological State: Cancer

237
Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer

W Tang, G Li, Q Lin, Z Zhu, Z Wang, Z Wang

Journal of Translational Medicine (Springer) China, 07 December 2023

Oncology

Key words: Gastric cancer, Cholersterol metabolism, Metabolic subtypes, Immunotheerapy, Prognostic signature, Biomarkers

Organism: Human

Tissue: Stomach

Pathological State: Cancer

238
Pro‐inflammatory cytokine IL‐6 regulates LMO4 expression in psoriatic keratinocytes via AKT/STAT3 pathway

Z Tu, W Wei, Q Xiang, W Wang, S Zhang, H Zhou

Immunity, Inflammation and Disease (Wiley Online Library) China, 06 December 2023

Dermatology, Molecular Biology

Key words: AKT, interleukin‐6, LMO4, psoriasis, STAT3

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

Cell Line: HaCaT cells

239
ALDOB/KAT2A interactions epigenetically modulate TGF-β expression and T cell functions in hepatocellular carcinogenesis

C Yin, C Zhang, Y Wang, G Liu, N Wang, N Liang, L Zhang, Q Tu, J Lv, H Jiang, H Ma, C Du, M Li, X He, S Chen, J Guo, S Li, J Qin, N Li, Y Tao, H Yin

Hepatology (AASLD) China, 05 December 2023

Hepathology, Oncology

Organism: Human, Mouse

Tissue: Liver

Pathological State: Cancer

240
Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma

J Duan, Y Zhang, R Chen, L Liang, Y Huo, S Lu, J Zhao, C Hu, Y Sun, K Yang, M Chen, Y Yu, J Ying, R Huang, X Ma, S Leaw, F Bai, Z Shen, S Cai, D Gao, J Wang, Z Wang

Cell Reports Medicine (Cell Press) China, 04 December 2023

Oncology, Pharmacology

Key words: squamous NSCLC, PD-1 blockade, biomarkers PD-L1, tumor mutational burden, gene expression signature, NRF2, tislelizumab clinical trial, immunotherapy

Organism: Human

Tissue: Lung

Pathological State: Cancer

241
SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats

A Shankar, CK Deal, S McCahon, K Callegari, T Seitz, L Yan, DM Drown, CT Williams

Chronobiology International (Taylor & Francis) USA, 04 December 2023

Nutritional science, Gastroenterology

Key words: Photoperiod, seasonal affective disorder, metabolic dysbiosis, non-alcoholic fatty liver disease

Organism: Rat

Tissue: Liver

Pathological State: Liver steatosis (fatty liver)

242
Excessive Lipid Peroxidation in Uterine Epithelium Causes Implantation Failure and Pregnancy Loss

Y Lu, Y Shao, W Cui, Z Jia, Q Zhang, Q Zhao, ZJ Chen, J Yan, B Chu, J Yuan

Advanced Science (Wiley) China, 03 December 2023

Reproductive Medicine

Organism: Mouse

Tissue: Uterus

Pathological State: Excessive Lipid Peroxidation

243
A prognostic model based on Scissor+ cancer associated fibroblasts identified from bulk and single cell RNA sequencing data in head and neck squamous cell carcinoma

G Tian, J Zhang, Y Bao, Q Li, J Hou

Cellular Signalling (Elsevier) China, 03 December 2023

Oncology

Key words: HNSCC, Fibroblasts, Scissor, scRNA-seq

Organism: Human

Pathological State: Cancer

Cell Line: GSE117973, GSE65858

244
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway

XC Wang, XL Li, XN Ma, LD Zhang, TY Han, DK Zhang

Naunyn-Schmiedeberg's Archives of Pharmacology (Springer) China, 02 December 2023

Gastroenterology, Pharmacology

Key words: Autophagy, Dihydromyricetin, Inflammatory bowel disease, Intestinal fibrosis

Organism: Mouse

Tissue: Colon

Pathological State: Intestinal fibrosis associated with inflammatory bowel disease (IBD)

245
Downregulation of N4-acetylcytidine modification in myeloid cells attenuates immunotherapy and exacerbates hepatocellular carcinoma progression

N Xu, J Zhuo, Y Chen, R Su, H Chen, Z Zhang, Z Lian, D Lu, X Wei, S Zheng, X Xu, S Wang, Q Wei

British Journal of Cancer (Nature) China, 01 December 2023

Oncology, Pharmacology

Key words: Cancer immunotherapy, Translational research

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

246
Spatiotemporal characterization of glial cell activation in an Alzheimer's disease model by spatially resolved transcriptomics

H Choi, EJ Lee, JS Shin, H Kim, S Bae, Y Choi, DS Lee

Experimental & Molecular Medicine (Nature) South Korea, 01 December 2023

Neuroscience

Key words: Alzheimer's disease, Transcriptomics, Translational research

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

247
Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury

K Štepánková, M Chudíčková, Z Šimková, N Martinez-Varea, S Kubinová, L Machová Urdzíková, P Jendelová, JF Kwok

Scientific Reports (Nature) Czech Republic, UK, 29 November 2023

Neuroscience, Pharmacology

Key words: Molecular neuroscience, Regeneration and repair in the nervous system, Synaptic plasticity

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal cord injury

248
Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development

T Vanova, J Sedmik, J Raska, KA Cerna, P Taus, V Pospisilova, M Nezvedova, V Fedorova, S Kadakova, H Klimova, M Capandova, P Orviska, P Fojtik, S Bartova, K Plevova, Z Spacil, H Hribkova, D Bohaciakova

Cell Reports (Cell) Czech Republic, 28 November 2023

Neuroscience

Organism: Human

Pathological State: Alzheimer's Disease

Cell Line: Induced Pluripotent Stem Cells

249
Low-intensity exercise training increases systolic function of heart and MHCII low cardiac resident macrophages

G Wang, L Wang, X Wang, H Ye, W Ni, W Shao, C Dai, B Liu

Heliyon (Cell Press) China, 28 November 2023

Cardiology

Key words: Cardiac macrophage, Ejection fraction, Heart, Low-intensity exerciseInnate immunity

Organism: Mouse

Tissue: Heart

250
FiCRoN, a deep learning-based algorithm for the automatic determination of intracellular parasite burden from fluorescence microscopy images

G Juez-Castillo, B Valencia-Vidal, LM Orrego, M Cabello-Donayre, L Montosa-Hidalgo, JM Pérez-Victoria

Medical Image Analysis (Elsevier) Spain, Colombia, 28 November 2023

Key words: Deep learning, Fluorescence imaging, Heme, Intracellular parasites, Leishmania

251
Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

A Eigentler, F Handle, S Schanung, A Degen, H Hackl, HHH. Erb, G Fotakis, J Hoefer, C Ploner, K Jöhrer, I Heidegger, A Pircher, W Klotz, M Herold, G Schäfer, Z Culig, M Puhr

Oncogene (Nature) Austria, Germany, 28 November 2023

Oncology, Pharmacology

Key words: Extracellular matrix, Extracellular signalling molecules, Hormone receptors, Prostate cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

252
Analysis of cells of epithelial, connective tissue and immune differentiation in HPV-positive-, HPV-negative oropharyngeal carcinoma and normal oropharyngeal tissue by immunofluorescence multiplex image cytometry: a preliminary report

AI Giotakis, A Runge, J Dudas, R Glueckert, T Gottfried, VH Schartinger, J Klarer, A Randhawa, E Caimmi, H Riechelmann

BMC cancer (Springer) Austria, USA, 27 November 2023

Oncology, Cell Biology

Key words: Image cytometry, Fluorescent antibody technique, Epithelial cells, Connective tissue, Leukocytes, Oropharyngeal neoplasms, Human papilloma virus

Organism: Human

Pathological State: Cancer

253
Diverse macrophage populations contribute to distinct manifestations of human cutaneous graft-versus-host disease

J Strobl, LM Gail, L Krecu, S Madad, Lisa Kleissl, L Unterluggauer, A Redl, K Brazdilova, S Saluzzo, P Wohlfarth, HA Knaus, M Mitterbauer, W Rabitsch, M Haniffa, G Stary

British Journal of Dermatology (Oxford Academic) Austria, UK, 27 November 2023

Immunology, Dermatology

Organism: Human

Tissue: Skin

Pathological State: Graft-versus-Host Disease

254
Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway

MQ Yan, BH Zhu, XH Liu, YM Yang, XY Duan, Y Wang, H Sun, M Feng, T Li, XM Liu

Cell Death & Disease (Nature) China, 27 November 2023

Reproductive Medicine

Key words: Cell proliferation, HIPPO signalling, Infertility, Mitochondria

Organism: Mouse

Tissue: Ovaries

255
Double‐Orthogonal Gradient‐Based High‐Throughput Screening Platform for Studying Cell Response Toward Combined Physicochemical Biomaterial Properties

TAB van der Boon, LE Tromp, L Ge, L Yang, CF Guimaraes, PT Kühn, Q Zhou, RA Bank, TG van Kooten, P van Rijn

Small Science (Wiley) The Netherlands, China, 27 November 2023

Tissue Engineering

Key words: biointerfaces, combinatorial gradients, high-throughput screenings, materiobiology, stem cells

Organism: Human

Cell Line: hBM-MSCs 

256
Acute expression of human APOBEC3B in mice results in RNA editing and lethality

A Alonso de la Vega, NA Temiz, R Tasakis, K Somogyi, L Salgueiro, E Zimmer, M Ramos, A Diaz-Jimenez, S Chocarro, M Fernández-Vaquero, B Stefanovska, E Reuveni, U Ben-David, A Stenzinger, T Poth, M Heikenwälder, N Papavasiliou, RS Harris, R Sotillo

Genome Biology (Springer) Germany, USA, Israel, 24 November 2023

Genetics

Key words: APOBEC3B, RNA editing, Mutations, Mouse models, DNA damage

Organism: Mouse

Tissue: Liver, Pancreas, Small Intestine, Lung, Spleen

257
Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8+ exhausted-like T cells

S Li, K Li, K Wang, H Yu, X Wang, M Shi, Z Liang, Z Yang, Y Hu, Y Li, H Li, S Cheng, L Ye, Y Yang

Nature Communications (Nature) China, 24 November 2023

Oncology, Radiotherapy

Key words: Cancer therapy, Hepatocellular carcinoma, Radiotherapy, Tumour immunology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

258
Brief Review of the Origins of Plastination

NE Ottone

Advances in Plastination Techniques (Springer) , 23 November 2023

259
Epoxy Sheet Plastination Technique

NE Ottone

Advances in Plastination Techniques (Springer) , 23 November 2023

260
Improved cardioprotective effect of 3‐nitro‐N‐methyl salicylamide solution after a prolonged preservation time of rat heart

S Wang, W Liu, S Liu, J Li, Y Geng, Y Zhao

Clinical and Experimental Pharmacology and Physiology (Wiley) China, 23 November 2023

Cardiology

Organism: Rat

Tissue: Heart

Pathological State: Myocardial injury

261
Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and in vitro experiments

H Chen, J Sameshima, S Yokomizo, T Sueyoshi, H Nagano, Y Miyahara, T Sakamoto, S Fujii, T Kiyoshima, T Guy, S Nakamura, M Moriyama, N Kaneko, S Kawano

Frontiers in Immunology (Frontiers Media S.A.) Japan, UK, 23 November 2023

Immunology, Oncology

Key words: oral squamous cell carcinoma, CD4+ cytotoxic T lymphocytes, CTLA-4, T cell dysfunction, CXCL13, double negative B cells

Organism: Human

Tissue: Tongue

Pathological State: Cancer

262
Qi Fu Yin ameliorates neuroinflammation through inhibiting RAGE and TLR4/NF-κB pathway in AD model rats

C He, W Yu, M Yang, Z Li, J Yu, D Zhong, S Deng, Z Song, S Cheng

Aging (Impact Journals) China, 22 November 2023

Neurology, Pharmacology

Key words: Alzheimer’s disease, traditional Chinese medicine, neuroinflammation, RAGE, TLR4/NF-κB signaling pathway

Organism: Rat

Tissue: Brain

Pathological State: Neuroinflammation

263
Identification of tryptophan metabolism-related genes in immunity and immunotherapy in Alzheimer's disease

Z Song, ZX Wu, RS Luo, C He, Z Li, M Yang, W Yu, JW He, S Deng, S Cheng

Aging (Impact Journals) China, 20 November 2023

Immunology, Neurology

Key words: Alzheimer’s disease, tryptophan metabolism-related genes, DEGs, WGCNA, bioinformatics

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s disease

264
Pharmacological effects and mechanism of Maxing Shigan decoction in the treatment of Pseudomonas aeruginosa pneumonia

Y Xu, L Bao, S Cao, B Pang, J Zhang, Y Zhang, M Chen, Y Wang, Q Sun, R Zhao, S Guo, J Sun, X Cui

Journal of Ethnopharmacology (Elsevier) China, 19 November 2023

Pharmacology

Organism: Mouse

Tissue: Lung

Pathological State: Pseudomonas aeruginosa pneumonia

265
Impact of Perinatal Co-exposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs (preprint)

M Lahimer, N Djekkoun, SZ Tricotteaux-Zarqaoui, A Corona, I Lafosse, HB Ali, M Ajina, V Bach, M Benkhalifa, HC Khorsi-Cauet

Toxics (MDPI) France, Tunisia, 19 November 2023

Nutritional science, Reproductive Medicine

Key words: chlorpyrifos; high-fat diet; Kisspeptin; GnRHR; ovary; testis; rat

Organism: Rat

Tissue: Ovaries, Testis

266
Vasari-Based Features Nomogram to Predict the Tumor-Infiltrating CD8+ T Cell Levels in Glioblastoma

C Xue, Q Zhou, B Zhang, X Ke, P Zhang, X Liu, S Li, J Deng, J Zhou

Academic Radiology (Elsevier) China, 18 November 2023

Radiotherapy, Oncology

Key words: CD8 + T cells; Glioblastoma; Magnetic resonance imaging; Visually AcceSAble Rembrandt Images.

Organism: Human

Tissue: Brain

Pathological State: Cancer

267
Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model

Z Zhang, N Zhang, X Lu, M Zhou, X Yan, W Gu, J Yang, Q Zhang, C Zhang, Y Gong, M Jia, X Zhang, P Ning, M Liu, X Li, X Shi, W Liu, GF Gao, G Ning, J Wang, Y Bi

Zoological Research (Oxford Academic) China, 18 November 2023

Virology

Key words: SARS-CoV-2, Diabetes, Mouse model, Heparin, Antiviral therapy

Organism: Human, Mouse

Tissue: Lung

Pathological State: Viral Infection

268
Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer

S Kandala, M Ramos, LV von Voithenberg, A Diaz-Jimenez, S Chocarro, J Keding, B Brors, CD Imbusch, R Sotillo

Cell Reports (Cell Press) Germany, 17 November 2023

Oncology

Key words: CP: Cancer; CP: Cell biology; Her2(+) breast cancer; NF-κβ signaling; chromosomal instability; immune evasion; senescence-associated secretory phenotype, SASP; single-cell sequencing.

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

269
Exploring CD39 and CD73 Expression as Potential Biomarkers in Prostate Cancer

CFF Gardani, EL Pedrazza, VS Paz, GG Zanirati, J Costa da Costa, R Andrejew, H Ulrich, JN Scholl, F Figueiró, L Rockenbach, F Bueno Morrone

Pharmaceuticals (MDPI) Brazil, 16 November 2023

Oncology

Key words: prostate cancer; ectonucleotidases; CD39; CD73; extracellular vesicles

Organism: Human

Tissue: Prostate

Pathological State: Cancer

270
Structural, electrochemical, biological, and mechanical assessment of functionally graded Cr-based multilayers for enhanced metal-ceramic bond strength in dental restorations

M Dinu, CM Cotrut, T Petreus, T Hauffman, F Baciu, A Vladescu

Materials Chemistry and Physics (Elsevier) Romania, UK, Belgium, Russia, 15 November 2023

Biomaterials

Key words: Oxynitride, Cathodic arc, EIS, Cytotoxicity, Bond strength

Cell Line: Human gingival fibroblasts

271
Impact of the-1T> C single-nucleotide polymorphism of the CD40 gene on the development of endothelial dysfunction in a pro-diabetic microenvironment

P Joshi, F Mohr, C Rumig, E Kliemank, G Krenning, S Kopf, M Hecker, AH Wagner

Atherosclerosis (Elsevier) Germany, The Netherlands, 14 November 2023

Endocrinology

Key words: Single nucleotide polymorphism, CD40, Endothelial cells, Endothelial-to-mesenchymal transition

Pathological State: Type 2 diabetes and type 1 diabetes

Cell Line: Human endothelial cells

272
Transcriptional regulation of macrophage inflammation in the heart failure with preserved ejection fraction: a translational study

E Gorica, SA Mohammed, A Mengozzi, S Ambrosini, FA Wenzl, A Mongelli, F Ruschitzka, N Hamdani, S Costantino, F Paneni

European Heart Journal (Oxford Academic) , 09 November 2023

273
Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling

Q Wang, H Lin, C Shen, M Zhang, X Wang, M Yuan, M Yuan, S Jia, Z Cao, C Wu, B Chen, A Gao, Y Bi, G Ning, W Wang, J Wang, R Liu

Gut Microbes (Taylor & Francis) China, 09 November 2023

Gastroenterology

Key words: Microbiome, GLP-1, bile acid, TGR5, ileum, diabetes

Organism: Mouse

Tissue: Small Intestine

Pathological State: Induced Intestinal Fibrosis

274
Autopsy analysis reveals increased macrophage infiltration and cell apoptosis in COVID-19 patients with severe pulmonary fibrosis

SQ Xiao, TZ Wen, XY Chen, HY Chen, Z Li, ZC He, T Luo, R Tang, WJ Fu, MF Cao, L Chen, Q Niu, S Wang, Y Lan, J Ge, QR Li, HT Guo, YX Wang, YF Ping, H Shen, Y Wang, YQ Ding, XW Bian, XH Yao

Pathology - Research and Practice (Elsevier) China, 08 November 2023

Virology

Key words: COVID-19, Respiratory failure, Histopathology, Macrophage, Apotosis

Organism: Human

Tissue: Lung

Pathological State: Viral Infection

275
Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K

Y Miyahara, H Chen, M Moriyama, K Mochizuki, N Kaneko, AR Haque, A Chinju, K Kai, M Sakamoto, N Kakizoe-Ishiguro, M Yamauchi, K Ogata, T Kiyoshima, S Kawano, S Nakamura

Scientific reports (Nature) Japan, Bangladesh, 07 November 2023

Immunology, Dermatology

Key words: Inflammation, Innate immunity, Lymphocytes, Mucosal immunology

Organism: Human

Tissue: Mucosa

Pathological State: Oral Lichen Planus (OLP) and hyperkeratosis

276
Use of Atrial Fibrillation Electrograms and T1/T2 Magnetic Resonance Imaging to Define the Progressive Nature of Molecular and Structural Remodeling–A New Paradigm Underlying the Emergence of Persistent Atrial Fibrillation

M Rottmann, S Yoo, A Pfenniger, A Mikhailov, B Benefield, DA Johnson, W Zhang, AK Ghosh, D Kim, R Passman, BP Knight, DC Lee, R Arora

Journal of the American Heart Association (AHA) USA, 06 November 2023

Cardiology

Key words: Atrial Fibrillation, Electrophysiology, Fibrosis, Magnetic Resonance Imaging (MRI), Oxidant Stress

Organism: Dog

Tissue: Heart

Pathological State: Atrial Fibrillation

277
A novel lncRNA GM15416 regulates osteoblast apoptosis and differentiation through the c-Fos/Fas axis and mitigates osteoporosis

D Zhao, J He, X Zhao, X Sheng, Z Feng, X Wang, C Zhang, S Wang, B Geng, Y Xia

International Journal of Biological Macromolecules (Elsevier) China, 02 November 2023

Osteology

Key words: lncRNA GM15416, C-Fos, Osteoporosis

Organism: Mouse

Tissue: Bone

Pathological State: osteoporosis

278
Heterogeneity of Phase II Enzyme Ligands on Controlling the Progression of Human Gastric Cancer Organoids as Stem Cell Therapy Model

DC Wu, CC Ku, JB Pan, K Wuputra, YH Yang, CJ Liu, YC Liu, K Kato, S Saito, YC Lin, IW CHong, M Hsiao, HM Hu, CH Kuo, KK Kuo, CS Lin, KK Yokoyama

International Journal of Molecular Sciences (MDPI) Taiwan, 02 November 2023

Oncology, Stem Cell Research

Key words: cinnamaldehyde; gastric cancer development; organoids; perillaldehyde; reactive oxygen species

Organism: Human

Tissue: Organoid

Pathological State: Cancer

279
Topical application of synthetic melanin promotes tissue repair

D Biyashev, ZE Siwicka, UV Onay, M Demczuk, D Xu, MK Ernst, ST Evans, CV Nguyen, FA Son, NK Paul, NC McCallum, OK Farha, SD Miller, NC Gianneschi, KQ Lu

NPJ Regenerative Medicine (Nature) USA, 02 November 2023

Dermatology

Key words: Biomaterials, Cell death and immune response, Trauma

Organism: Mouse

Tissue: Skin

Pathological State: Acute skin injury

280
Group 3 innate lymphoid cells exacerbate lupus nephritis by promoting B cell activation in kidney ectopic lymphoid structures

F Li, Z Liang, H Zhong, X Hu, Z Tang, C Zhu, J Shen, X Han, R Lin, R Zheng, R Tang, H Peng, X Zheng, C Mo, P Chen, X Wang, Q Wen, J Li, X Xia, H Ye, Y Qiu, J Yu, D Fu, J Liu, R Wang, H Xie, Y Guo, X Li, J Fan, Q Liu, H Mao, W Chen, Y Zhou

Advanced Science (Wiley) China, 01 November 2023

Nephrology

Organism: Human

Tissue: Kidney

Pathological State: Lupus nephritis

281
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene

Q Sun, D Liu, W Cui, H Cheng, L Huang, R Zhang, J Gu, S Liu, X Zhuang, Y Lu, B Chu, J Li

Communications Biology (Nature) China, 01 November 2023

Metabolism

Key words: Lipid peroxides, Sterols

Organism: Mouse

Tissue: Liver

282
Estrogen-related genes for thyroid cancer prognosis, immune infiltration, staging, and drug sensitivity

L Zhang, M Zhou, X Gao, Y Xie, J Xiao, T Liu, X Zeng

BMC Cancer (BMC) China, 31 October 2023

Oncology

Key words: Estrogen-related genes, Estrogen-related differential expressed genes, Progression-free interval, Thyroid cancer, Immune infiltration, Clinical relevance, Drug sensitivity

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

283
CD24hiCD27+ Bregs within metastatic lymph nodes promote multi-drug resistance in breast cancer

H Huang, Y Yao, L Shen, J Jiang, T Zhang, J Xiong, J Li, S Sun, S Zheng, F Jia, J Zhou, X Yu, W Chen, J Shen, W Xia, X Shao, Q Wang, J Huang, C Ni

Clinical Cancer Research (AACR) China, 31 October 2023

Oncology, Pharmacology

Organism: Mouse

Tissue: Xenograft Tumor, Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

284
EXOSC5 maintains cancer stem cell activity in endometrial cancer by regulating the NTN4/integrin β1 signalling axis

YH Huang, WL Wang, PH Wang, HT Lee, WW Chang

International Journal of Biological Sciences (Ivy SPring) Taiwan, 31 October 2023

Oncology, Stem Cell Research

Key words: Endometrial carcinoma, cancer stem cells, c-MYC, EXOSC5, NTN4, integrin β1

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

285
Antigen-caged-adjuvant nanovaccines elicit potent humoral and cellular immune responses

K Chen, Z Zhang, J Zhang, Z Fang, W Dong, Y Wang, M Li

Nano Today (Elsevier) China, 31 October 2023

Immunology, Nanomedicine

Cell Line: murine DC2.4 cells and B16-F10 melanoma cells

286
Tumor-infiltrating platelets promote the growth of lung adenocarcinoma

X Li, M Li, Z Hu, L Zhou, M Zheng, D Jiao, J Qin, B Fu, X Zheng, H Wei

Translational Oncology (Elsevier) China, 27 October 2023

Oncology

Key words: NSCLC, Lung adenocarcinoma, Tumor-infiltrating platelets, Fibrinogen, Coagulation

Organism: Human

Tissue: Lung

Pathological State: Cancer

287
Acidosis promotes the metastatic colonization of lung cancer via remodeling of the extracellular matrix and vasculogenic mimicry

WY Shie, PH Chu, MYP Kuo, HW Chen, MT Lin, XJ Su, YL Hong, HYE Chou

International Journal of Oncology (Spandios Publications) Taiwan, 26 October 2023

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

288
Dual antibody-aided mesoporous nanoreactor for H2O2 self-supplying chemodynamic therapy and checkpoint blockade immunotherapy in triple-negative breast cancer

YT Chen, YX Luo, SH Chan, WY Chiu, HWW Yang

Journal of Nanobiotechnology (Springer) Taiwan, 24 October 2023

Oncology, Pharmacology

Key words: Triple-negative Breast cancer (TNBC), Mesoporous nanoreactors, Chemodynamic therapy (CDT), Checkpoint blockade immunotherapy, Collaborative treatment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

289
Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imaging

DE Cohn, A Forder, EA Marshall, EA Vucic, GL Stewart, K Noureddine, WW Lockwood, CE MacAulay, M Guillaud, WL Lam

Frontiers in Immunology (Frontiers Media S.A.) Canada, USA, 23 October 2023

Oncology, Bioimaging

Key words: tumor immune microenvironment (TIME), tumor microenvironment (TME), tumor-infiltrating lymphocytes, immune checkpoint blockade, non-cell autonomous interactions, multiplexed imaging

290
Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice

AM Schmid, A Razim, M Wysmołek, D Kerekes, M Haunstetter, P Kohl, G Brazhnikov, N Geissler, M Thaler, E Krčmářová, M Šindelář, T Weinmayer, J Hrdý, K Schmidt, P Nejsum, B Whitehead, J Palmfeldt, S Schild, A Inić-Kanada, U Wiedermann, I Schabussova

Cell Communication and Signaling (Springer) Austria, Poland, Czech Republic, Denmark, 20 October 2023

Immunology

Key words: Allergic airway inflammation, Extracellular vesicles, Outer membrane vesicles, Microbiota and innate immunity, Nasal route of administration

Organism: Mouse

Tissue: Lung

Pathological State: E. coli O83 Infection

291
Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development

T Vanova, J Sedmik, J Raska, KA Cerna, P Taus, V Pospisilova, M Nezvedova, V Fedorova, S Kadakova, H Klimova, M Capandova, P Orviska, P Fojtik, S Bartova, K Plevova, Z Spacil, H Hribkova, D Bohaciakova

Cell Reports (Cell Press) Czech Republic, 20 October 2023

Neuroscience

Organism: Human

Tissue: Organoid

Pathological State: Alzheimer’s disease

292
Proteomic profiling of advanced melanoma patients to predict therapeutic response to anti-PD-1 therapy

N Zila, OM Eichhoff, I Steiner, T Mohr, A Bileck, PF Cheng, A Leitner, L Gillet, T Sajic, S Goetze, B Friedrich, P Bortel, J Strobl, R Reitermaier, SA Hogan, JM Martínez-Gómez, R Staeger, F Tuchmann, S Peters, G Stary, M Kuttke, A Elbe-Buerger, C Hoeller, R Kunstfeld, W Weninger, B Wollscheid, R Dummer, LE French, C Gerner, R Aebersold, MP Levesque, V Paulitschke

Clinical Cancer Research (AACR) Austria, Switzerland, Germany, 20 October 2023

Oncology, Pharmacology

Key words: Predictive biomarker, Immunotherapy, Serum depletion, Glycoproteomics, SWATH/DIA mass spectrometry

Organism: Human

Tissue: Skin

Pathological State: Cancer

293
TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD

L Sun, Y Chen, L Xia, J Wang, J Zhu, J Li, K Wang, K Shen, D Zhang, G Zhang, T Shi, W Chen

Oncogene (Nature) China, 20 October 2023

Oncology

Key words: Apoptosis, Extracellular matrix, Gastric cancer, Ubiquitylation

Organism: Human

Tissue: Stomach

Pathological State: Cancer

294
Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma

Z Cai, L Chen, S Chen, R Fang, X Chen, W Lei

Cell Communication and Signaling (Springer) China, 18 October 2023

Oncology

Key words: Single-cell RNA sequencing, Hypopharyngeal squamous cell carcinoma, Tumor microenvironment, Extracellular matrix cancer-associated fibroblast, Precision therapy

Organism: Human

Tissue: Carcinoma

Pathological State: Cancer

295
Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization

CY Ko, YY Lin, D Achudhan, JW Chang, SC Liu, CY Lai, YL Huang, CH Tsai, YC Fong, HT Chen, KT Lee, CC Huang, TK Chang, CH Tang

International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan, 18 October 2023

Osteology, Immunology

Key words: Omentin-1, Osteoarthritis, IL-4, M2 macrophage, Anti-inflammation

Organism: Human, Rat

Tissue: Synovium

Pathological State: Osteoarthritis

296
Effect of the Functional VP1 Unique Region of Human Parvovirus B19 in Causing Skin Fibrosis of Systemic Sclerosis

DY Chen, CC Tzang, CM Liu, TM Chiu, JW Lin, PH Chuang, CW Kuo, BS Tzang, TC Hsu

International Journal of Molecular Sciences (MDPI) Taiwan, 18 October 2023

Dermatology

Key words: human parvovirus B19 (B19), systemic sclerosis (SSc), VP1 unique region (VP1u), macrophages, fibrosis

Organism: Human

Tissue: Skin

Pathological State: Human Parvovirus B19 induced Skin Fibrosis

297
Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate

O Ertunc, E Smearman, Q Zheng, JL Hicks, JA Brosnan-Cashman, T Jones, C Gomes-Alexandre, L Trabzonlu, AK Meeker, AM De Marzo, CM Heaphy

The Prostate (Wiley) USA, 17 October 2023

Oncology

Key words: chromogenic, diagnostic, in situ hybridization, prostate cancer, telomeres

Organism: Human

Tissue: Prostate

Pathological State: Cancer

298
Danggui Shaoyao San ameliorates the lipid metabolism via the PPAR signaling pathway in a Danio rerio (zebrafish) model of hyperlipidemia

Y Wang, Y Pan, M Hou, R Luo, J He, F Lin, X Xia, P Li, C He, P He, S Cheng, Z Song

Biomedicine & Pharmacotherapy (Elsevier) China, 16 October 2023

Endocrinology

Key words: Danggui Shaoyao San, Hyperlipidemia, PPAR signaling pathway, Danio rerio, Lipid metabolism

Organism: Zebrafish

Tissue: Liver

Pathological State: Hyperlipidemia

299
Light damage induces inflammatory factors in mouse retina and vitreous humor

W Liu, X Zhu, X Ge, Y Chen, DWC Li, L Gong

Molecular Vision (Emory University) China, 15 October 2023

Ophthalmology

Organism: Mouse

Tissue: Eye

Pathological State: Inflammation

300
Hypoxic microenvironment determines the phenotypic plasticity and spatial distribution of cancer‐associated fibroblasts

JI Choi, EJ Cho, MJ Yang, HJ Noh, SH Park, S Kim, YS Kim, CO Sung, D Lee

Clinical and Translational Medicine (ncbi.nlm.nih.gov) South Korea, 14 October 2023

Oncology

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

301
Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland

Z Wang, L Zhang, B Li, J Song, M Yu, J Zhang, C Chen, J Zhan, H Zhang

Cell Death & Disease (Nature) China, 13 October 2023

Reproductive Medicine

Key words: Cell signalling, Differentiation

Organism: Mouse

Tissue: Breast

302
A marmoset brain cell census reveals regional specialization of cellular identities

FM Krienen, KM Levandowski, H Zaniewski, RCH Del Rosario, ME Schroeder, M Goldman, M Weinisch, A Lufservitz, VF Beja-Glasser, C Chen, Q Zhang, KY Chan, KX Li, J Sharma, D McCormack, TW Shin, A Harrahill, E Nyase, G Mudhar, A Mauermann, A Wysoker, J Nemesh, S Kashin, J Vergara, G Chelini, J Dimidschstein, S Berretta, BE Deverman, E Boyden, SA McCarroll, G Feng

Science Advances (Science) USA, Italy, 12 October 2023

Neuroscience, Zoology

Organism: Monkey

Tissue: Brain

303
A molecular landscape of quiescence and proliferation highlights the role of Pten in mammary gland acinogenesis

R Tomasin, AM Rodrigues, AC Manucci, A Bruni-Cardoso

Journal of Cell Science (The Company of Biologists) Brazil, 11 October 2023

Cell Biology

Key words: Pten, Basement membrane, Cell cycle, Extracellular matrix, Mammary gland acinogenesis, Quiescence

Organism: Mouse

Tissue: Breast

Cell Line: EpH4 cells

304
Donor bone marrow–derived macrophage engraftment into the central nervous system of patients following allogeneic transplantion

AM Loeb, SS Pattwell, S Meshinchi, A Bedalov, KR Loeb

Blood Advances (ASH Publications) USA, 10 October 2023

Hematology

Key words: Immunobiology and Immunotherapy, Transplantation

Organism: Human

Tissue: Brain

Pathological State: Hematopoietic stem cell transplantation

305
Novel ratio-expressions of genes enables estimation of wound age in contused skeletal muscle

N Li, X Liang, X Bai, X Liang, L Dang, Q Jin, J Cao, QX Du, JH Sun

International Journal of Legal Medicine (Springer) China, 07 October 2023

Osteology

Key words: Ratio-expressions of genes, Real-time PCR, Wound age estimation, Skeletal muscle

Organism: Rat

Tissue: Muscle

306
Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition

A Yu, J Hu, L Fu, G Huang, D Deng, M Zhang, Y Wang, G Shu, L Jing, H Li, X Chen, T Yang, J Wei, Z Chen, X Zu

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 06 October 2023

Oncology

Organism: Human

Tissue: Bladder

Pathological State: Cancer

307
Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition

A Yu, J Hu, L Fu, G Huang, D Deng, M Zhang, Y Wang, G Shu, L Jing, H Li, X Chen, T Yang, J Wei, J Luo

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 06 October 2023

Oncology

Key words: Tumor Microenvironment, Immunotherapy, Urinary Bladder Neoplasms

Organism: Human

Tissue: Bladder

Pathological State: Cancer

308
A comprehensive strategy to strengthen bioimaging in Africa through the Africa Microscopy Initiative

MA Reiche, CA Jacobs, JS Aaron, V Mizrahi, DF Warner, TL Chew

Nature Cell Biology (Nature) South Africa, USA, 06 October 2023

Bioimaging

Key words: Imaging, Microscopy

309
Local reference values ​​for tissue characterization by cardiac magnetic resonanceimaging. Myocardial mapping using parametric sequences

L Gutiérrez, SA Tejera, AL Ortego, CR Secotaro, J Nerviani, JA Cubillos, JC Daza, JE Briggs, P Briggs, FA Peñafort

Revista de la Federación Argentina de Cardiología (Federación Argentina de Cardiología) Argentina, 06 October 2023

Cardiology

Key words: Tissue Characterization,T1 Mapping, T2 Mapping,extracellular volume

310
Acrylamide, an Air Pollutant, Enhances Allergen-Induced Eosinophilic Lung Inflammation via Group 2 Innate Lymphoid Cells

HH Su, CM Cheng, YN Yang, YW Chang, CY Li, ST Wu, CC Lin, HE Wu, JL Suen

Mucosal Immunology (Elsevier) Taiwan, 05 October 2023

Allergy Research

Key words: Acrylamide, Air pollutant, Asthma, Eosinophilic Inflammation, Group 2 innate lymphoid cell

Organism: Mouse

Tissue: Lung

Pathological State: Asthma

311
A comprehensive strategy to strengthen bioimaging in Africa though the Africa Microscopy Initiative

MA Reiche, CA Jacobs, JS Aaron, V Mizrahi, DF Warner, TL Chew

Nature Cell Biology (Nature) South Africa, 05 October 2023

Key words: Imaging, Microscopy

312
Development of an image processing software for quantification of histological calcification staining images

X Li, YT Chan, Y Jiang

PloS one (PLOS) China, 05 October 2023

Medical Image Analysis

Key words: Alizarin staining, Histology, Imaging techniques, Calcification, Cell staining, Hematoxylin staining, Staining Stem cells

313
The RBPMSCreERT2-tdTomato mouse line for studying retinal and vascular relevant diseases

G Li, Y Luo, Q Zhang, W Chen, K Lai, Y Liu, Y Zheng

Iscience (Cell Press) China, 02 October 2023

Biological Methods

Key words: Natural sciences, Biological sciences, Physiology, Biological sciences research methodologies

Organism: Mouse

Tissue: Eye

314
Transitional Selves

M Chakravorty

api.taylorfrancis.com () , 01 October 2023

315
Donor bone marrow–derived macrophage engraftment into the central nervous system of patients following allogeneic transplantation

AM Loeb, SS Pattwell, S Meshinchi, A Bedalov, KR Loeb

Blood Advances (ASH Publications) USA, 29 September 2023

Transplantation Medicine

Key words: Immunobiology and Immunotherapy, Transplantation

Organism: Human

Tissue: Brain

316
Activation of the p62-Keap1-Nrf2 pathway protects against oxidative stress and excessive autophagy in ovarian granulosa cells to attenuate DEHP-induced ovarian impairment in mice

B Xu, T He, H Yang, W Dai, L Liu, X Ma, J Ma, G Yang, R Si, X Du, X Fu, X Pei

Ecotoxicology and Environmental Safety (Elsevier) China, 28 September 2023

Toxicology, Reproductive Medicine

Key words: Di-(2-ethylhexyl) phthalate, Female reproductive toxicity, Ovarian granulosa cells, Excessive autophagy, Oxidative stress, P62-Keap1-Nrf2 pathway

Organism: Mouse

Tissue: Ovaries

317
Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice

L Yang, P Lu, X Qi, Q Yang, L Liu, T Dou, Q Guan, C Yu

Iscience (Elsevier) China, 27 September 2023

Endocrinology

Key words: Physiology, Molecular biology, Neuroscience, Immunology

Organism: Mouse

Tissue: Brain

Pathological State: Obesity

318
A comparative analysis of microglial inducible Cre lines

TE Faust, PA Feinberg, C O'Connor, R Kawaguchi, A Chan, H Strasburger, M Frosch, MA Boyle, T Masuda, L Amann, KP Knobeloch, M Prinz, A Schaefer, DP Schafer

Cell Reports (Cell Press) USA, Germany, Japan, 26 September 2023

Neuroscience

Key words: Microglia, Cre/LoxP, CreER, recombination

Organism: Mouse

Tissue: Brain

319
Ex Vivo Evaluation of Combination Immunotherapy Using Tumor‐Microenvironment‐on‐Chip

HY Mu, CM Lin, LA Chu, YH Lin, J Li, CY Liu, HC Huang, SL Cheng, TY Lee, HM Lee, HM Chen, YJ Tsai, Y Chen, JH Huang

Advanced Healthcare Materials (Wiley) Taiwan, 25 September 2023

Pharmacology, Oncology

320
ROCK inhibition reduces the sensitivity of mutant p53 glioblastoma to genotoxic stress through a Rac1-driven ROS production

YT Magalhaes, FL Forti

The International Journal of Biochemistry & Cell Biology (Elsevier) Austria, 23 September 2023

Immunology, SARS-CoV-2

Key words: Neutrophil Extracellular Traps, Oxidative Stress, Post-Acute COVID-19 Syndrome, Thromboinflammation, Thrombosis

Cell Line: GBM cell lines U87-MG (wild type p53) and T98G (mutant p53)

321
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma

L Wang, QF Zhao, BB Yang, HJ Liang, XE Zhang, XY Zhang, WJ Yang, ZY Guo, X Xu, F Tian, QH Wu

Acta Oncologica (Taylor & Francis) China, 22 September 2023

Oncology

Key words: STAT3, EphA7, transcription, ESCC, promoter

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

322
Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D

M Liu, L Liu, H Guo, X Fan, T Liu, C Xu, Z He, Y Song, L Gao, S Shao, J Zhao, P Lu

iScience (Cell Press) China, 22 September 2023

Hepathology

323
Effect of different sperm populations on neutrophils extracellular traps (NETs) formation in cattle

R Rivera-Concha, C Moya, M León, P Uribe, M Schulz, A Prado, A Taubert, C Hermosilla, R Sánchez, F Zambrano

Research in Veterinary Science (Elsevier) Chile, Germany, 22 September 2023

Zoology, Reproductive Medicine

Key words: Bovine, Spermatozoa, Neutrophil extracellular traps, Sperm motility

Organism: Cow

Cell Line: Sperm

324
Optimising multiplex immunofluorescence staining for characterising the tumour immune micro-environment

R Cohen, T Lee-Pullen, TJ Miller, K Meehan, K Fuller, MJ McCoy

Methods (Elsevier) Australia, 21 September 2023

Microscopy

Key words: Colorectal cancer, Multiplex immunofluorescence, Automated staining, Tumor immune microenvironment

Organism: Human

Tissue: Colon

Pathological State: Cancer

325
Platinum-Based Twin Drug Modulates Tumor-Infiltrating Immune Cells to Improve Immune Checkpoint Blockade Therapy

Y Hao, R Li, Y Min

Journal of Medicinal Chemistry (ACS Publications) China, 20 September 2023

Oncology, Immunology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

326
The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

NN Liu, CX Yi, LQ Wei, JA Zhou, T Jiang, CC Hu, L Wang, YY Wang, Y Zou, YK Zhao, LL Zhang, YT Nie, YJ Zhu, XY Yi, LB Zeng, JQ Li, XT Huang, HB Ji, Z Kozlakidis, L Zhong, C Heeschen, XQ Zheng, C Chen, P Zhang, H Wang

Cancer Cell (Cell Press) China, France, 19 September 2023

Oncology

Key words: Aspergillus, CARD9, IL-1β, β-glucan, Intratumor mycobiome, Lung adenocarcinoma, Myeloid-Derived Suppressor Cells.

Organism: Mouse

Tissue: Lung, Allograft Tumor

Pathological State: Cancer

327
Propolis as a Potential Therapeutic Agent to Counteract Age-Related Changes in Cartilage: An In Vivo Study

C Arias, B Vásquez, LA Salazar

International Journal of Molecular Sciences (MDPI) Chile, 19 September 2023

Rheumatology

Key words: Osteoarthritis, Propolis, Aging

Organism: Rat

Tissue: Joint Tissue

328
Impact of Perinatal Coexposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs

M Lahimer, N Djekkoun, S Tricotteaux-Zarqaoui, A Corona, I Lafosse, HB Ali, M Ajina, V Bach, M Benkhalifa, H Khorsi-Cauet

Toxics (MDPI) France, Tunisia, 19 September 2023

Reproductive Medicine, Endocrinology

Key words: chlorpyrifos, high-fat diet, Kisspeptin, GnRHR, ovary, testis, rat

Organism: Rat

Tissue: Ovaries, Testis

329
Postirradiation temperature influences DSB repair and dicentric chromosome formation—potential impact for dicentric chromosome analysis in interlaboratory comparisons

C Beinke, M Port, H Scherthan

Radiation Protection Dosimetry (Oxford Academic) Germany, 18 September 2023

Radiotherapy

Cell Line: Human peripheral blood mononuclear cells (PBMCs)

330
RNA‐binding protein‐regulated fibronectin is essential for EGFR‐activated metastasis of head and neck squamous cell carcinoma

JM Shieh, TW Chang, JH Wang, SP Liang, PL Kao, LY Chen, CJ Yen, YJ Chen, WC Chang, BK Chen

The FASEB Journal (Wiley) Taiwan, 17 September 2023

Oncology

Key words: EGF, fibronectin, metastasis, RNA- binding protein

Organism: Mouse

Tissue: Xenograft Tumor, Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

331
A molecular landscape of quiescence/proliferation highlights the role of Pten in mammary gland acinogenesis

R Tomasin, AM Rodrigues, AC Manucci, A Bruni, Cardoso

Journal of Cell Science (The Company of Biologists) Brazil, 15 September 2023

Oncology

Key words: Pten, Basement membrane, Cell cycle, Extracellular matrix, Mammary gland acinogenesis, Quiescence

Cell Line: EpH4 cells

332
Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation

RE Stamateris, HV Landa-Galvan, RB Sharma, C Darko, D Redmond, SG Rane, LC Alonso

The Journal of Clinical Investigation (ncbi.nlm.nih.gov) USA, 15 September 2023

Endocrinology

Key words: Metabolism, Beta cells, Cell cycle, Insulin

Organism: Mouse

Tissue: Pancreas

333
Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

N Tsutsumi, Z Masoumi, SC James, JA Tucker, H Winkelman, W Grey, LK Picton, L Moss, SC Wilson, NA Caveney, KM Jude, C Gati, J Piehler, IS Hitchcock, KC Garcia

Cell (Cell Press) USA, Japan, UK, Germany, 14 September 2023

Hematology

Key words: JAK-STAT, TpoR, c-MPL, cryo-EM, hematopoiesis, ligand engineering, mTOR, signaling, structure, thrombopoietin

Organism: Mouse

Tissue: Bone Marrow

334
Community-developed checklists for publishing images and image analyses

C Schmied, MS Nelson, S Avilov, GJ Bakker, C Bertocchi, J Bischof, U Boehm, J Brocher, MT Carvalho, C Chiritescu, J Christopher, BA Cimini, E Conde-Sousa, M Ebner, R Ecker, K Eliceiri, J Fernandez-Rodriguez, N Gaudreault, L Gelman, D Grunwald, T Gu, N Halidi, M Hammer, M Hartley, M Held, F Jug, V Kapoor, AA Koksoy, J Lacoste, S Le Dévédec, S Le Guyader, P Liu, GG Martins, A Mathur, K Miura, P Montero Llopis, R Nitschke, A North, AC Parslow, A Payne-Dwyer, L Plantard, R Ali, B Schroth-Diez, L Schütz, RT Scott, A Seitz, O Selchow, VP Sharma, M Spitaler, S Srinivasan, C Strambio-De-Castillia, D Taatjes, C Tischer, HK Jambor

Nature Methods (Nature) Italy, USA, Germany, the Netherlands, Chile, Portugal, Australia, Austria, Sweden, Spain, UK, France, Canada, China, Saudi Arabia, Switzerland, 14 September 2023

Microscopy

Key words: Microscopy, Publishing

335
Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours

Q Wang, Q Liang, J Dou, H Zhou, C Zeng, H Pan, Y Shen, Q Li, Y Liu, DT Leong, W Jiang, Y Wang

Nature Nanotechnology (Nature) China, Singapore, 14 September 2023

Nanomedicine, Oncology

Key words: Drug delivery, Nanoparticles, Nanotechnology in cancer

Organism: Mouse

Tissue: Xenograft Tumor, Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

336
Construction and validation of cervical cancer prognostic model based on tumor immune cycle-related genes

C Huang, T Wen, S Lu, J Liang, Q Wang

Chinese Journal of Oncology Prevention and Treatment (manu33.magtech.com.cn) China, 12 September 2023

Oncology

Key words: Cervical cancer, Prognostic model, Tumor immune cycle related genes, Multi?color , fluorescence immunohistochemistry

337
The combination of quercetin and leucine synergistically improves grip strength by attenuating muscle atrophy by multiple mechanisms in mice exposed to cisplatin

TH Hsu, TJ Wu, YA Tai, CS Huang, JW Liao, SL Yeh

Plos one (PLOS) Taiwan, 12 September 2023

Myology

Key words: Leucine, Muscle tissue, Muscle proteins, Gastrocnemius muscles, Glycogens, Skeletal muscles, Muscle protein synthesis, Cancer treatment

Organism: Mouse

Tissue: Muscle

338
FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway

L Yin, R Cao, Z Liu, G Luo, Y Li, X Zhou, X Chen, Y Wu, J He, X Zu, Y Shen

Acta Biochimica et Biophysica Sinica (Oxford University Press) China, 11 September 2023

Oncology

Key words: FUNDC2, GLI1, triple-negative breast cancer (TNBC), therapeutic target

Organism: Human

Tissue: Breast

Pathological State: Cancer

339
Aralia saponin A isolated from Achyranthes bidentata Bl. ameliorates LPS/D-GalN induced acute liver injury via SPHK1/S1P/S1PR1 pathway in vivo and in vitro

M Zeng, A Feng, L Wang, K Li, J Zhou

International Immunopharmacology (Elsevier) China, 11 September 2023

Hepathology

Key words: Acute liver injury; Aralia saponin A; Metabonomics; SPHK1/S1P/S1PR1 pathway; Transcriptomics.

Organism: Mouse

Tissue: Liver

Pathological State: Acute Liver Injury

340
Fibroblast growth factor 5 expression predicts the progression of oral squamous cell carcinoma

WY Shie, SJ Cheng, KC Chen, CC Tang, HH Peng, HH Ko, HH Hou, HYE Chou

Journal of the Formosan Medical Association (Elsevier) Taiwan, 11 September 2023

Oncology

Key words: Fibroblast growth factor 5, Oral cancer, Progression, Risk factors, Survival

Organism: Mouse

Tissue: Xenograft Tumor, Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

341
Technological Innovations and the Advancement of Preventive Healthcare for Society 5.0

Z Mkhize-Kwitshana, P Naidoo, L Fourie, RC Ecker, Z Dlamini

Society 5.0 and Next Generation Healthcare (Springer) South Africa, Austria, Australia, 10 September 2023

Key words: Preventive medicine, Healthcare, Therapeutic healthcare, Diagnostic healthcare, Low- and middle-income countries, SDGs, Energy crisis, Human rights, Data ownership

342
Thymopentin ameliorates experimental colitis via inhibiting neutrophil extracellular traps

D Cao, K Qian, N Yang, G Xu, X Wang, M Zhu, Y Wang, H Li, J Shen, Y Zhang, Z Cui

International Immunopharmacology (Elsevier) China, 09 September 2023

Immunology, Gastroenterology

Key words: Crohn's disease, Thymopentin, Neutrophil extracellular traps, Colitis, Neoseptin 3

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

343
Innate Mechanism of Mucosal Barrier Erosion in the Pathogenesis of Acquired Colitis

WH Yang, PV Aziz, DM Heithoff, Y Kim, JY Ko, JW Cho, MJ Mahan, M Sperandio, JD Marth

iScience (Cell Press) USA, South Korea, Germany, 09 September 2023

Gastroenterology, Immunology

Key words: Biochemistry, Molecular biology, Immunology, Microbiology

Organism: Mouse

Tissue: Small Intestine

Pathological State: Colitis

344
Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients

YT Wu, HY Tay, JT Yang, HH Liao, YS Ma, YH Wei

Journal of Biomedical Science (Springer) Taiwan, 09 September 2023

Neuroscience

Key words: AMPARs, Disease modeling, Electrophysiological activity, Excitatory neurons, iPSCs, MERRF syndrome, mtDNA mutation, Neurological defect, Synaptic plasticity, Synaptophysin

Cell Line: human iPSCs

345
Formin protein FMNL1 is a biomarker for tumor-infiltrating immune cells and associated with well immunotherapeutic response

G Lu, H Wang, R Xu, J Xu, F An, H Xu, H Nie, J Mei, Q Zhan, Q Zhang

Journal of Cancer (Ivyspring International Publisher) China, 09 September 2023

Oncology

Key words: FMNL1, bioinformatics, biomarker, cancer, mQIF

Organism: Human

Tissue: Liver

Pathological State: Cancer

346
A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

C Li, Y Lin, Y Chen, X Song, X Zheng, J Li, J He, X Chen, C Huang, W Wang, J Wu, J Wu, J Gao, Z Tu, XJ Li, S Yan, S Li

Advanced Science (Wiley) China, 08 September 2023

Neuroscience, Cell Biology

Key words: HD KI-140Q mice, intravenous injection, lysosome, mini-intrabody, mu-tant huntingtin, SM3, stereotaxic injection

Organism: Mouse

Tissue: Brain

Pathological State: Huntington's disease

347
Neutrophil extracellular traps are involved in the occurrence of interstitial lung disease in a murine experimental autoimmune myositis model

L Bai, J Zhu, W Ma, F Li, P Zhao, S Zhang

Clinical and Experimental Immunology (Oxford Academic) China, 08 September 2023

Immunology

Key words: idiopathic inflammatory myopathy (IIMs), experimental autoimmune myositis (EAM), interstitial lung disease (ILD), neutrophil extracellular traps (NETs)

Organism: Mouse

Tissue: Lung

Pathological State: Interstitial Lung Disease

348
Genomic and Phenotypic Biomarkers for Precision Medicine Guidance in Advanced Prostate Cancer

F Davoudi, A Moradi, TM Becker, JG Lock, B Abbey, D Fontanarosa, A Haworth, J Clements, RC Ecker, J Batra

Current Treatment Options in Oncology (Springer) Australia, Iran, Austria, 08 September 2023

Oncology

Key words: Advanced prostate cancer, Genotypic biomarkers, Phenotypic biomarkers, Precision medicine

349
Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors

Y Chen, T Yamamoto, Y Takahashi, T Moro, T Tajima, Y Sakaguchi, N Sakata, A Yokoyama, S Hijioka, A Sada, Y Tabata, R Ohki

Cell Death & Disease (Nature) Japan, 07 September 2023

Oncology, Endocrinology

Key words: Cancer models, Neuroendocrine cancer

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

350
Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC

X Zhou, J An, R Kurilov, B Brors, K Hu, T Peccerella, S Roessler, K Pfütze, A Schulz, S Wolf, N Hohmann, D Theile, M Sauter, J Burhenne, S Ei, U Heger, O Strobel, ST Barry, C Springfeld, C Tjaden, F Bergmann, M Büchler, T Hackert, F Fortunato, JP Neoptolemos, P Bailey

Nature Cancer (Nature) Germany, Japan, Austria, UK, Portugal, 07 September 2023

Oncology

Key words: Cancer, Pancreatic cancer, Tumour biomarkers

Organism: Human

Tissue: Pancreas, Spheroid

Pathological State: Cancer

351
Correlation of tumor-associated macrophage infiltration in glioblastoma with magnetic resonance imaging characteristics: a retrospective cross-sectional study

Q Zhou, C Xue, J Man, P Zhang, X Ke, J Zhao, B Zhang, J Zhou

Quantitative Imaging in Medicine and Surgery (AME Publishing Company) China, 07 September 2023

Oncology, Microscopy

Key words: Glioblastoma (Gb), tumor-associated macrophage (TAM), magnetic resonance imaging (MRI), tumor microenvironment

Organism: Human

Tissue: Brain

Pathological State: Cancer

352
PTBP1 plays an important role in the development of gastric cancer

Z Chu, M Zhu, Y Luo, Y Hu, X Feng, H Wang, M Sunagawa, Y Liu

Cancer Cell International (BMC) China, Japan, 05 September 2023

Oncology

Key words: PTBP1:Polypyrimidine Tract binding protein 1, Gastric cancer, Proliferation, Actin cytoskeleton remodeling, PTBP1 Cas9-KO mouse model

Organism: Human

Tissue: Stomach

Pathological State: Cancer

353
Genomic and Transcriptomic Landscape of an Oral Squamous Cell Carcinoma Mouse Model for Immunotherapy

YM Lee, CL Hsu, YH Chen, DL Ou, C Hsu, CT Tan

Cancer Immunology Research (AACR) Taiwan, 05 September 2023

Oncology, Immunology

Organism: Mouse

Tissue: Tongue

Pathological State: Cancer

354
Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activation

CJ Shen, RH Chan, BW Lin, NC Li, YH Huang, WC Chang, BK Chen

Theranostics (Ivyspring International Publisher) Taiwan, 05 September 2023

Oncology

Key words: multigene mutant CRC, oleic acid, IL-8, KRAS activation, metastasis

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

355
SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells

Y Wang, JM Wang, Y Xiao, XB Hu, SY Zheng, JL Fu, L Zhang, YW Gan, XM Liang, DWC Li

Aging (Impact Journals) China, 04 September 2023

Ophthalmology

Key words: lens, cataract, apoptosis, DBC1, p53, oxidative stress

Cell Line: Mouse lens epithelial cell line (αTN4-1) and Human lens epithelial cell line (HLE and FHL124)

356
The combination of NDUFS1 with CD4+ T cell infiltration predicts favorable prognosis in kidney renal clear cell carcinoma

D Wu, L He, Z Xu, RF Tian, XY Fan, J Fan, J Ai, HJ Bian, WJ Qin, J Qin, L Li

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 04 September 2023

Nephrology

Key words: kidney renal clear cell carcinoma, NDUFS1, survival, hsa-miR-320b, CD4+ T cell infiltration

Organism: Human

Tissue: Kidney

Pathological State: Cancer

357
Platinum Twin and Triplet Drugs Improve Chemoimmunotherapy

Y Hao, R Li, W Pan, S Tian, Y Min

Journal of Medicinal Chemistry (ACS Publications) China, USA, 04 September 2023

Oncology, Pharmacology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

358
NETs induce persistent lung tissue damage via thromboinflammation without altering virus resolution in a mouse coronavirus model

M Salzmann, P Gibler, P Haider, M Brekalo, R Plasenzotti, T Filip, R Nistelberger, B Hartmann, J Wojta, C Hengstenberg, BK Podesser, JB Kral-Pointer, PJ Hohensinner

Journal of Thrombosis and Haemostasis (Elsevier) Austria, 04 September 2023

Pulmonology, Immunology, SARS-CoV-2

Key words: Neutrophil Extracellular Traps, Oxidative Stress, Post-Acute COVID-19 Syndrome, Thromboinflammation, Thrombosis

Organism: Mouse

Tissue: Lung

Pathological State: Viral Infection

359
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

X Zheng, C Huang, Y Lin, B Han, Y Chen, C Li, J Li, Y Ding, X Song, W Wang, W Liang, J Wu, J Wu, J Gao, C Wei, X Zhang, T Zhuchi, Y Sen

Signal Transduction and Targeted Therapy (Nature) China, 04 September 2023

Genetics

Key words: Experimental models of disease, Genetic engineering

Organism: Monkey

Tissue: Breast

Pathological State: Cancer

360
Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4+ T cells through regulating type 2 conventional dendritic cells

J Luo, S Pang, Z Hui, H Zhao, S Xu, W Yu, L Yang, Q Sun, X Hao, F Wie, J Wang, X Ren

Theranostics (Ivyspring) China, 04 September 2023

Oncology, Pharmacology

Key words: STING, ADU-S100, Tim-3, DC, Cancer immunotherapy

Organism: Human

Tissue: Lung

Pathological State: Cancer

361
Anti-tumor effects of deubiquitinating enzyme inhibitor PR-619 in human chondrosarcoma through reduced cell proliferation and endoplasmic reticulum stress-related apoptosis

WC Lin, YL Chiu, KL Kuo, PM Chow, CH Hsu, SM Liao, JR Dong, SC Chang, SW Liu, TJ Liu, FS Hsu, KC Wang, YC Lin, CC Chang, KY Huang

American Journal of Cancer Research (e-Century Publishing) Taiwan, 03 September 2023

Oncology

Key words: Deubiquitinating enzyme, chondrosarcoma, apoptosis, endoplasmic reticulum stress

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

362
Plasmon-activated water as a therapeutic strategy in Alzheimer's disease by altering gut microbiota

CH Cheng, YC Liu, YCSH Yang, KJ Lin, D Wu, YR Liu, CC Chang, CT Hong, CJ Hu

Aging (Impact Journals) Taiwan, 02 September 2023

Neuroscience, Gastroenterology

Key words: Alzheimer’s disease, plasmon-activated water, fecal microbiota transplantation, microbiota, beta amyloid, tau

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s disease

363
Impact of apolipoprotein A1 on tumor immune microenvironment, clinical prognosis and genomic landscape in hepatocellular carcinoma

Y Wang, S Chen, X Xiao, F Yang, J Wang, H Zong, Y Gao, C Huang, X Xu, M Fang, X Zhang, C Gao

Precision Clinical Medicine (Oxford Academic) China, The Netherlands, 02 September 2023

Oncology

Organism: Human

Tissue: Liver

Pathological State: Cancer

364
Mesenchymal stem cells promote polarization of M2 macrophages in mice with acute-on-chronic liver failure via Mertk/JAK1/STAT6 signaling

Z Li, J Chen, J Zhang, Z Lei, L Wu, S Meng, J Wang, J Xiong, DN Lin, Jz Wang, ZL Gao, BL Lin

Stem Cells (Oxford Academic) China, 02 September 2023

Stem Cell Research, Hepathology

Key words: mesenchymal stem cell, acute-on-chronic liver failure, macrophage, polarization, Mertk, JAK1/STAT6

Organism: Mouse

Tissue: Liver

Pathological State: Liver failure

365
Escherichia coli adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4

W Zhang, L Xu, X Zhang, J Xu, JO Jin

Frontiers in Immunology (Frontiers Media S.A.) China, South Korea, 01 September 2023

Immunology

Key words: fimH, macrophage polarization, toll-like receptor 4, myeloid differentiation factor 2, tumor-associated macrophage

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

366
Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma

L Pang, M Dunterman, S Guo, F Khan, Y Liu, E Taefi, A Bahrami, C Geula, WH Hsu, C Horbinski, CD James, P Chen

Nature Immunology (Nature) USA, 31 August 2023

Oncology, Immunology

Key words: Cancer immunotherapy, Immunosurveillance, Stem cells, Tumour immunology

Cell Line: HMC3 microglia, 293T cells, CT2A cells, SIM-A9 microglia, and SB28 and GL261 cells

367
The Cooperative Human Tissue Network of the National Cancer Institute: Supporting cancer research for 35 years

SJ McCall, IA Lubensky, CA Moskaluk, A Parwani, K Radin, NC Ramirez, Z Von Menchhofen, MK Washington, VA LiVolsi

Molecular Cancer Therapeutics (AACR) USA, 30 August 2023

Oncology

368
Engineering tumoral vascular leakiness with gold nanoparticles

MI Setyawati, Q Wang, N Ni, JK Tee, K Ariga, PC Ke, HK Ho, Y Wang, DT Leong

Nature Communications (Nature) Singapore, China, Japan, Australia, 30 August 2023

Oncology, Nanomedicine

Key words: Cancer, Nanoscale materials

Organism: Mouse

Tissue: Xenograft Tumor, Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

369
FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth

M Yu, W Wu, Y Sun, H Yan, L Zhang, Z Wang, Y Gong, T Wang, Q Li, J Song, M Wang, J Zhang, Y Tang, J Zhan, H Zhang

Cell Reports (Cell Press) China, 29 August 2023

Oncology

Key words: CDK4, CP: Cancer, CP: Molecular biology, CRC, FRMD8, MDM2, RB.

Organism: Human

Tissue: Colon

Pathological State: Cancer

370
Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling

L Chen, L Zhang, G Jin, Y Liu, N Guo, H Sun, Y Jiang, X Zhang, G He, G Lv, J Yang, X Tu, T Dong, H Liu, J An, G Si, Z Kang, H Li, S Yi, G Chen, W Liu, Y Yang, J Ou

Cell Reports (Cell Press) China, 29 August 2023

Hepathology

Key words: 5-aminolevulinate, CP: Immunology, CP: Metabolism, CX3CR1, P53, hepatectomy, hepatocyte proliferation, insulin-like growth factor 1, liver regeneration, liver zonation, macrophage polarization, partial liver transplantation

Organism: Mouse

Tissue: Liver

371
Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

X Ma, Q Wang, C Sun, I Agarwal, H Wu, J Chen, C Zhao, G Qi, Q Teng, C Yuan, S Yan, J Peng, R Li, K Song, Q Zhang, B Kong

Cell Reports (Cell Press) China, 29 August 2023

Oncology, Immunology

Key words: IFN-β signaling, T cell exhaustion, TCF19, endometrial cancer, immune checkpoint blockade therapy, microsatellite instable

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

372
Single-cell transcriptomics reveals granzyme K–expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD

R Aoyagi, T Maehara, R Koga, R Munemura, T Tomonaga, Y Murakami, A Doi, H Yamamoto, T Kiyoshima, S Kawano, S Nakamura

Journal of Allergy and Clinical Immunology (Elsevier) Japan, 29 August 2023

Immunology

Key words: Single-cell RNA sequencing, IgG4-related disease, germinal center, granzyme K, T follicular helper cells, T follicular regulatory cells

Organism: Human

Tissue: Submandibular Gland, Lymphoid Tissue, Kidney

Pathological State: IgG4-related disease

373
The rs1421085 variant within FTO promotes brown fat thermogenesis

Z Zhang, N Chen, N Yin, R Liu, Y He, D Li, M Tong, A Gao, P Lu, Y Zhao, H Li, J Zhang, D Zhang, W Gu, J Hong, W Wang, L Qi, G Ning, J Wang

Nature Metabolism (Nature) China, USA, 29 August 2023

Endocrinology

Key words: Fat metabolism, Genome-wide association studies, Mechanisms of disease

Organism: Human

Tissue: Adipose Tissue

374
Mitochondrial integrated stress response controls lung epithelial cell fate

SH Han, M Lee, Y Shin, R Giovanni, RP Chakrabarty, MM Herrerias, LA Dada, AS Flozak, PA Reyfman, B Khuder, CR Reczek, L Gao, J Lopéz-Barneo, CJ Gottardi, GR Scott Budinger, NS Chandel

Nature (Nature) USA, South Korea, Spain, 28 August 2023

Pulmonology

Key words: Differentiation, Metabolomics

Organism: Mouse

Tissue: Lung

375
Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4+ T cells through regulating type 2 conventional dendritic cells

J Luo, S Pang, Z Hui, H Zhao, S Xu, W Yu, L Yang, Q Sun, X Hao, F Wei, J Wang, X Ren

Theranostics (Ivyspring International Publisher) China, 25 August 2023

Oncology, Immunology

Key words: STING, ADU-S100, Tim-3, DC, Cancer immunotherapy

Organism: Human

Tissue: Lung

Pathological State: Cancer

376
Anti-angiogenic therapy using the multi-tyrosine kinase inhibitor Regorafenib enhances tumor progression in a transgenic mouse model of ß-cell carcinogenesis

MJ Egidi, S Krug, J Haybaeck, P Michl, H Griesmann

British Journal of Cancer (Nature) Germany, Austria, 24 August 2023

Oncology

Key words: Pancreatic cancer, Target validation, Tumour angiogenesis

Organism: Mouse

Tissue: Placenta

Pathological State: Cancer

377
Clinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence

Y Zhang, Y Bai, XX Ma, JK Song, Y Luo, XY Fei, Y Ru, Y Luo, JS Jiang, Z Zhang, D Yang, TT Xue, HP Zhang, TY Liu, YW Xiang, L Kuai, YQ Liu, B Li

Cell Death & Disease (Nature) China, 24 August 2023

Oncology

Key words: Melanoma, Prognostic markers

Organism: Human

Tissue: Skin

Pathological State: Cancer

378
PNU-74654 Induces Cell Cycle Arrest and Inhibits EMT Progression in Pancreatic Cancer

TL Chien, YC Wu, HL Lee, WW Sung, CY Yu, YC Chang, CC Lin, CC Wang, MC Tsai

Medicina (MDPI) Taiwan, 24 August 2023

Oncology, Pharmacology

Key words: pancreatic adenocarcinoma, β-catenin, WNT, cell cycle arrest, migration

Cell Line: BxPC-3 and MiaPaCa-2 cell lines

379
Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress

ZY Yang, XC Yan, L Liang, CC Gao, PR Zhang, Y Liu, JX Sun, B Ruan, JL Duan, RN Wang, XX Feng, B Che T Xiao, H Han

The Journal of Clinical Investigation (Am Soc Clin Investig) China, 22 August 2023

Oncology

Key words: SPEN, rDNA, nucleolar stress, pRNA, endothelial cells, tumor vessels

Organism: Mouse

Tissue: Eye

Pathological State: Cancer

380
Chemotherapy-induced nanovaccines implement immunogenicity equivalence for improving cancer chemoimmunotherapy

R Li, Y Hao, K Roche, G Chen, W Pan, AZ Wang, Y Min

Biomaterials (Elsevier) China, USA, 21 August 2023

Oncology, Pharmacology

Key words: Chemoimmunotherapy, Nanovaccines, Neoantigens, Damage associated molecular patterns, Anti-PD-1

Organism: Mouse

Tissue: Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

381
Integrative Evaluation of the Clinical Significance Underlying Protein Arginine Methyltransferases in Hepatocellular Carcinoma

Y Jiang, S Wei, JM Koo, HJ Kim, W Park, Y Zhang, H Guo, KT Ha, CM Oh, JS Kang, JH Jeong, D Ryu, KJ Kim, Y Jo

Cancers (MDPI) China, South Korea, 20 August 2023

Oncology

Key words: protein arginine methyltransferase, protein methylation, hepatocellular carcinoma, T cell exhaustion, tissue microarray, prognostic marker

Organism: Human

Tissue: Liver

Pathological State: Cancer

382
Cellular Membrane-Engineered Nanovesicles as a Three-Stage Booster to Target the Lesion Core

F Huang, Y Du, Y Chen, Z Qiu, Z Wang, Y Fan, Y Shi, Z Li, K Yang, W Cui, W Jin

Advanced Materials (Wiley) China, 17 August 2023

Pharmacology, Nanomedicine

383
High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach

CM Hsu, KC Chang, TM Chuang, ML Chu, PW Lin, HS Liu, SY Kao, YC Liu, CT Huang, MH Wang, TJ Yeh, YC Gau, JS Du, HC Wang, SF Cho, CE Hsiao, Y Tsai, SY Hsiao, LC Hung, CH Yen, HH Hsiao

Cancers (MDPI) Taiwan, USA, 17 August 2023

Oncology, Pharmacology

Key words: DLBCL, G9a/EHMT2, niclosamide, autophagy, immunohistochemistry, TissueFAXS PLUS, HistoQuest

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

384
Alveolar Ridge Augmentation with a Novel Combination of 3D-Printed Scaffolds and Adipose-Derived Mesenchymal Stem Cells—A Pilot Study in Pigs

CS Lau, J Chua, S Prasadh, J Lim, L Saigo, BT Goh

Biomedicines (MDPI) Singapore, USA, 16 August 2023

Tissue Engineering

Key words: alveolar ridge augmentation, 3D-printed scaffolds, adipose-derived mesenchymal stem cells, tissue engineering, pig model

Organism: Pig

Cell Line: Scaffold

385
An Engineered Adeno-Associated Virus Capsid Mediates Efficient Transduction of Pericytes and Smooth Muscle Cells of the Brain Vasculature

SH Ramirez, JF Hale, S McCarthy, CL Cardenas, KN Udeni Galpayage Dona, KS Hanlon, E Hudry, D De La Cruz, C Ng, S Das, DM Nguyen, J Nammour, RE Bennett, AM Andrews, PL Musolino, CA Maguire

Human Gene Therapy (Mary Ann) USA, 16 August 2023

Neuroscience, Pharmacology

Key words: adeno-associated virus vector, pericytes, smooth muscle cells

Organism: Mouse

Tissue: Brain, Blood Vessels

386
The putative protein kinase Stk36 is essential for ciliogenesis and CSF flow by associating with Ulk4

H Zhang, M Yang, J Zhang, L Li, T Guan, J Liu, X Gong, F Yang, S Shen, M Liu, Y Han

The FASEB Journal (Wiley) China, Ireland, 16 August 2023

Neuroscience

Key words: ependymal cells, hydrocephalus, motile cilia, Stk36, Ulk4, ventriculomegaly

Organism: Mouse

Tissue: Brain

387
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response

S Tan, Z Wang, N Li, X Guo, Y Zhang, H Ma, X Peng, Y Zhao, C Li, L Gao, T Li, X Lian, C Ma

Cell Death & Differentiation (Nature) China, 15 August 2023

Oncology, Immunology

Key words: Cancer microenvironment, Inflammation

Organism: Human

Tissue: Liver

Pathological State: Cancer

388
Obstruction of the Tear Drainage Altered Lacrimal Gland Structure and Function

B Xiao, D Guo, R Liu, M Tu, Z Chen, Y Zheng, C Liu, L Liang

Investigative Opthalmology & Visual Science (iovs.arvojournals.org) China, 12 August 2023

Ophthalmology

Organism: Mouse

Tissue: Eye

389
STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

J Pencik, C Philippe, M Schlederer, E Atas, M Pecoraro, S Grund-Gröschke, WJ Li, A Tracz, I Heidegger, S Lagger, K Trachtová, M Oberhuber, E Heitzer, O Aksoy, HA Neubauer, B Wingelhofer, A Orlova, N Witzeneder, T Dillinger, E Redl, G Greiner, D D’Andrea, JR Östman, S Tangermann, I Hermanova, G Schäfer, F Sternberg, EE Pohl, C Sternberg, A Varady, J Horvath, D Stoiber, TI Malcolm, SD Turner, EE Parkes, B Hantusch, G Egger, S Rose-John, V Poli, S Jain, CWD Armstrong, G Hoermann, V Goffin, F Aberger, R Moriggl, A Carracedo, C McKinney, RD Kennedy, H Klocker, MR Speicher, DG Tang, AA Moazzami, DM Heery, M Hacker, L Kenner

Molecular Brain (BMC) Austria, USA, Switzerland, Czech Republic, Sweden, Spain, UK, Italy, France, 12 August 2023

Oncology

Key words: STAT3, mTORC1, AR, Prostate Cancer, LKB1, AMPK, CREB, Metformin

Organism: Human

Tissue: Prostate

Pathological State: Cancer

390
Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery

K Wuputra, MH Tsai, K Kato, CC Ku, JB Pan, YH Yang, S Saito, CC Wu, YC Lin, KH Cheng, KK Kuo, M Noguchi, Y Nakamura, T Yoshioka, DC Wu, CSn Lin, KK Yokoyama

Inflammation and Regeneration (BMC) Taiwan, Japan, 11 August 2023

Cell Biology

Key words: Antioxidation, Aryl hydrocarbon receptor, Dioxin responsive element, Nuclear factor (erythroid-derived 2)-like 2 transcription factor, Jun dimerization protein 2, Oxidative stress, Reactive oxygen species, Transcriptional regulation

391
FK506-Binding Protein Like (FKBPL) Regulates Hypoxia-induced Factor-α and Restores Endothelial Function and Vascular Integrity in Ischaemia-induced Angiogenesis

L McClements, S Ghorbanpour, S Cartland, S Seth, R Ecker, C Richards, K McGrath, L Cole, M Warkiani, M Kavurma

Heart, Lung and Circulation (Elsevier) Australia, Austria, 10 August 2023

Cardiology

392
Case report: genetic and immune microenvironmental characteristics of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis who achieved complete remission after treatment with PD-1 inhibitor

Y Song, J Long, X Su, Z Chen, Y He, W Shao, B Wang, C Chen

Frontiers in Immunology (Frontiers Media S.A.) China, 09 August 2023

Oncology, Pharmacology

Key words: MSS, rectal cancer, hepatopulmonary metastasis, immunotherapy, tumor immune microenvironment

Organism: Human

Tissue: Colon

Pathological State: Cancer

393
Compartmentalized Nano-MOFs as Co-delivery Systems for Enhanced Antitumor Therapy

W Duan, L Hang, Y Ma, Q Wang, X Tang, W Jiang, Y Wu, W Lv, Y Wang

ACS Applied Materials & Interfaces (ACS Publications) China, 08 August 2023

Oncology, Pharmacology

Key words: bioactive macromolecules compartmentalized structures nano-metal-organic frameworks co-delivery cancer therapy

Organism: Mouse

Tissue: Xenograft Tumor, Liver, Kidney

Pathological State: Cancer

394
Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity

A Serrano‐Benitez, SE Wells, L Drummond-Clarke, LC Russo, JC Thomas, GA Leal, M Farrow, JM Edgerton, S Balasubramanian, M Yang, C Frezza, A Gautam, J Brazina, K Burdova, NC Hoch, SP Jackson, KW Caldecott

The EMBO Journal (EMBO Press) UK, Brazil, Germany, 07 August 2023

Cell Biology

Key words: bioactive macromolecules, compartmentalized structures, nano-metal-organic frameworks, co-delivery, cancer therapy

Cell Line: RPE-1, U2OS and SUM149 cells

395
Bj-PRO-10c, as an allosteric regulator of argininosuccinate synthase, is a potential therapy for neuroblastoma metastasis

F Coutinho, LMF Guimarães, R Seeger, APJ Santos, T Glaser, D Yamamoto, L Lacerda, V Arnaud-Sampaio, CVT Rossini, I Rabelo, NM de Medeiros, D Ramos Truzzi, M Aparecida Juliano, L Juliano, H Ulrich, C Lameu

Toxicon (Elsevier) Brazil, 06 August 2023

Oncology, Pharmacology

Key words: Metastasis, Nitric oxide, Proline-rich peptide, Neuroblastoma, Tumor progression

Cell Line: SH-SY5Y cells

396
Unveiling nature's potential weapon: Magnolol's role in combating bladder cancer by upregulating the miR-124 and inactivating PKC-δ/ERK axis

FT Hsu, WL Liu, SR Lee, LB Jeng, JH Chen

Phytomedicine (Elsevier) Taiwan, 05 August 2023

Oncology, Pharmacology

Key words: Bladder cancer, ERK, Magnolol, miR-124-3p, NF-κB, PKCδ

Organism: Mouse

Tissue: Kidney, Liver, Spleen, Small Intestine

397
Aberrant expression of IL-17A in mast cells contributes to the pathogenesis of hidradenitis suppurativa

CB Chu, CC Yang, YY Hsueh, PC Chen, YK Hong, YY Kuo, SJ Tsai

British Journal of Dermatology (Oxford Academic) Taiwan, 04 August 2023

Dermatology

Organism: Human

Tissue: Skin

Pathological State: Hidradenitis suppurativa

398
The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity

X Sun, L He, H Liu, RF Thorne, T Zeng, L Liu, B Zhang, M He, Y Huang, M Li, E Gao, M Ma, C Cheng, F Meng, C Lang, H Li, W Xiong, S Pan, D Ren, B Dang, Y Yang, M Wu, L Liu

Cell Metabolism (Cell Press) China, 04 August 2023

Oncology

Key words: diapause-like state, chemotherapy insensitivity, colorectal cancer, histone lactylation, polyploidy, glycolysis, SMC4

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

399
Evaluation of the prognostic and therapeutic potential of inhibin beta B for oral squamous cell carcinoma

YY Chung, SJ Cheng, HH Ko, WY Shie, HYE Chou

Journal of Dental Science (Elsevier) Taiwan, 04 August 2023

Oncology

Key words: INHBB, Menin, Oral squamous cell carcinoma, Prognostic factor

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

400
Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2‐dependent mechanism

WJ Ni, H Zhou, H Lu, NN Ma, BB Hou, W Li, FX Kong, JT Yu, R Hou, J Jin, JG Wen, T Zhang, XM Meng

Clinical and Translational Medicine (Wiley) China, 03 August 2023

Nephrology

Key words: chronic kidney disease, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2),methyltransferase-like 3 (METTL3),N6-methyladenosine (m6A), renal fibrosis, traditional Chinese medicine

Organism: Mouse

Tissue: Kidney

Pathological State: Renal fibrosis

Contact

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies).
You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.