NETotic Cells

FEATURED PUBLICATION

High Presence of NETotic Cells and Neutrophil Extracellular Traps in Vaginal Discharges of Women with Vaginitis: An Exploratory Study
Cells

Zambrano et al. investigated a rarely addressed issue in public health – infectious vaginitis – by characterizing NETotic cells and neutrophil extracellular traps (NETs) in vaginal discharges of women with vaginitis. Identification of extracellular DNA, neutrophil elastase, and citrullinated histones was performed with TissueFAXS i Plus system.

EMT

FEATURED PUBLICATION

Interplay between Partial EMT and Cisplatin Resistance as the Drivers for Recurrence in HNSCC
Biomedicines

In a recent study, Ingruber et al. investigated the role of partial epithelial to mesenchymal transition (pEMT)-related proteins in modulating Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC). To perform an in-depth quantitative analysis, the power of TissueFAXS platform and StrataQuest software was utilized.

Expression and clinical significance

FEATURED PUBLICATION

Expression and clinical significance of VISTA, B7-H3, and PD-L1 in glioma
Clinical Immunology

In a recent study, Wang et al. investigated RNA and protein expression of various immune checkpoint molecules, highlighting their prognostic value. To scan multiple markers simultaneously on TMAs the multispectral tissue cytometer TissueFAXS SPECTRA was used, as well as StrataQuest for in-depth phenotyping.

P2X7 receptor

FEATURED PUBLICATION

P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma
Frontiers in Oncology

Arnaud-Sampaio et al. addressed the persistent problem of drug resistance in cancer and elucidated the role of the P2X7 receptor in chemoresistance, using TissueFAXS platform for image acquisition and StrataQuest software for in-depth cytometric quantifications. The paper was published in Frontiers in Oncology.

Cytotoxic CD8+ T cells may be drivers

FEATURED PUBLICATION

Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome
scientific reports

In this study, published in scientific reports Nature, Kaneko et al. investigated the role of CD4+ and CD8+ T cell subsets in salivary glands of patients with Sjögren’s syndrome. In order to perform an in-depth quantitative analysis, the power of TissueFAXS platform, and both TissueQuest and StrataQuest software were utilized.

Adverse Effects of Single

FEATURED PUBLICATION

A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells
cancers

This study from Liang et al. (University of Gothenburg) assessed phenotypic and functional characteristics of tumor infiltrating lymphocytes within colorectal liver metastases (CRLM). For the in-situ tissue cytometry analysis, with the main focus on CD103+CD8+ TRM cells, the power of TissueFAXS CHROMA and StrataQuest was utilized.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Functional Impairment

FEATURED PUBLICATION

Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia
Immunity

In a recent study published in the journal Immunity, Collins et al (Ragon Institute of MGH, MIT and Harvard) were able to show key immunologic and virologic parameters of durable HIV control. For high resolution visualization of the virus, lymph node tissues were marked with HIV specific RNAScope probes and acquired using TissueFAXS Q.

Filter publications

Customer Publications (A total of 2312 papers published)

201
The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes

B Mahlobo, F Laher, W Smidt, F Ogunshola, T Khaba, T Nkosi, A Mbatha, T Ngubane, K Dong, I Jajbhay, J Pansegrouw, ZM Ndhlovu

BMC Immunology (BMC) South Africa, USA, 01 July 2022

Immunology

Key words: Follicular regulatory T cells (TFRs), Follicular helper T (TFH) cells, Lymph node, Biomarkers, HIV

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

202
Mutations in GCK May Lead to MODY2 by Reducing Glycogen Synthesis

Z Li, K Li, Y Sun, X Jiang, J Liu, J Li, L Fang, G Li, Q Guan, C Xu

Advanced Biology (Wiley) China, 30 June 2022

Endocrinology

Cell Line: HepG2 cells

203
An optimized method for obtaining clinical‐grade specific cell subpopulations from human umbilical cord‐derived mesenchymal stem cells

Y Jia, A Wang, B Zhao, C Wang, R Su, B Zhang, Z Fan, Q Zeng, L He, X Pei, W Yue

Cell Proliferation (Wiley) China, 29 June 2022

Biological Methods

Organism: Human

Cell Line: hUC-MSCs

204
The long-term survival and functional maturation of human iNPC-derived neurons in the basal forebrain of cynomolgus monkeys

S Feng, T Zhang, W Ke, Y Xiao, Z Guo, C Lu, S Li, Z Guo, Y Liu, G Tan, Y Chen, F Yue, Y Shu, C Yue, N Jing

Life Medicine (Oxford Academic) China, 28 June 2022

Stem Cell Research, Neuroscience

Key words: Non-human primates, Cerebral cell transplantation, Human induced neural stem/progenitor cells, Neuronal differentiation, Functional maturation

Organism: Cynomolgus Monkey

Tissue: Brain

205
Hepatitis B virus X gene impacts on the innate immunity and immune‐tolerant phase in chronic hepatitis B virus infection

KC Chang, HH Chua, YH Chen, DJ Tsuei, MH Lee, CL Chiang, YM Jeng, JF Wu, HL Chen, HY Hsu, YH Ni, MH Chang

Liver International (Wiley) Taiwan, 28 June 2022

Hepathology, Immunology

Organism: Human

Tissue: Liver

Pathological State: Chronic hepatitis B

206
Cancer-Associated Fibroblasts Promote Tumor Aggressiveness in Head and Neck Cancer through Chemokine Ligand 11 and CC Motif Chemokine Receptor 3 Signaling Circuit

WY Huang, YS Lin, YC Lin, S Nieh, YM Chang, TY Lee, SF Chen, KD Yang

Cancers (MDPI) Taiwan, 27 June 2022

Oncology

Key words: head and neck cancer, cancer-associated fibroblasts, CCL11, CCR3, tumor microenvironment

Pathological State: Cancer

Cell Line: FaDu cell lines (HTB-43 - ATCC)

207
Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure

R Zhang, S Chen, L Chen, L Ye, Y Jiang, H Peng, Z Guo, M Li, X Jiang, P Guo, D Yu, R Zhang, Y Niu, Y Zhuang, M Aschner, Y Zheng, D Li, W Chen

Particle and Fibre Toxicology (BMC) China, USA, 23 June 2022

Pulmonology

Key words: Particle matter, Chronic lung injuries, Single-cell RNA sequencing, IL-17A, Myeloid-derived suppressor cells

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

208
Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment

TY Wu, M Chen, IC Chen, YJ Chen, CY Chen, CH Wang, JJ Cheng, K Nepali, KH Chuang, JP Liou

Journal of Advanced Research (Elsevier) Taiwan, 22 June 2022

Oncology, Pharmacology

Key words: Cancer, Drug design, HDAC6/HSP90 dual inhibitor, Immunosensitizer, Tumor microenvironment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

209
PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis

J Luo, Q Lian, D Zhu, M Zhao, T Mei, B Shang, Z Yang, C Liu, W Xu, L Zhou, K Wu, X Liu, Y Lai, F Mao, W Li, C Zuo, K Zhang, M Lin, Y Zhou, Y Liu, L Lu, L Zhao

Genes & Diseases (Elsevier) China, 21 June 2022

Ophthalmology

Key words: Apoptosis, Glaucoma, Phagocytosis, PLSCR1, Retinal ganglion cells

Organism: Mouse

Tissue: Eye

Pathological State: Glaucoma

210
A diagnostic pitfall; small cell carcinoma-like features in basaloid squamous cell carcinoma of the esophagus

H Ishida, A Kasajima, T Yamauchi, R Akaishi, S Ueaki, Y Taniyama, F Fujishima, T Koike, T Kamei, AKY Lam, H Sasano

Histology and Histopathology (Griffith University) Japan, Australia, Germany, 21 June 2022

Oncology

Key words: esophagus, biopsy, basaloid squamous cell carcinoma, small cell carcinoma, diagnostic pitfall

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

211
Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer's Disease

SM Chen, TC Hsu, CH Chew, WT Huang, AL Chen, YF Lin, S Eddarkaoui, L Buee, CC Chen

International Journal of Molecular Sciences (MDPI) Taiwan, USA, France, 20 June 2022

Neuroscience, Pharmacology

Key words: neurodegenerative disease, Alzheimer’s disease (AD), passive immunotherapy, encapsulated cell therapy, microtube array membrane (MTAMs)

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

212
Clinical value of urinary cytokines/chemokines as prognostic markers in patients with crescentic glomerulonephritis

J Jeon, J Park, HJ Boo, KE Yang, CJ Lee, JE Lee, K Kim, GY Kwon, W Huh, DJ Kim, HR Jang

Scientific reports (Nature) South Korea, 17 June 2022

Nephrology

Key words: Chemokines, Cytokines, Kidney diseases

Organism: Human

Tissue: Kidney

Pathological State: Crescentic Glomerulonephritis

213
Decreased CD11c‐positive dendritic cells in the tumor microenvironment predict double‐hit/triple‐hit genotype and survival in diffuse large B‐cell lymphoma

CT Yuan, SS Chuang, PY Cheng, K Chang, H Wang, JH Tsai, JY Liau, WC Chou

The Journal of Pathology: Clinical Research (Wiley) Taiwan, 17 June 2022

Oncology

Key words: high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, double-hit lymphoma, triple-hit lymphoma, diffuse large B-cell lymphoma, tumor microenvironment, dendritic cell, decision curve analysis

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

214
Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF‐κB pathway

Y Li, Q Zhuang, L Tao, K Zheng, S Chen, Y Yang, C Feng, Z Wang, H Shi, J Shi, Y Fang, L Xiao, D Geng, Z Wang

Cell Proliferation (Wiley) China, 16 June 2022

Osteology

Organism: Mouse

Tissue: Bone

Pathological State: Osteoporosis

215
Evaluation of Topical and Subconjunctival Injection of Hyaluronic Acid-Coated Nanoparticles for Drug Delivery to Posterior Eye

CH Tsai, LN Hoang, CC Lin, LC Pan, CL Wu, IC Lin, PY Wang, CL Tseng

Pharmaceutics (MDPI) Taiwan, China, 13 June 2022

Nanomedicine

Key words: posterior eye, hyaluronic acid, surface charges, nanoparticles, drug delivery, eyedrops, subconjunctival injection, retina

Organism: Mouse

Tissue: Eye

216
Occurrence of Lymphangiogenesis in Peripheral Nerve Autografts Contrasts Schwann Cell-Induced Apoptosis of Lymphatic Endothelial Cells In Vitro

C Hromada, J Hartmann, J Oesterreicher, A Stoiber, A Daerr, B Schädl, E Priglinger, AH Teuschl-Woller, W Holnthoner, J Heinzel, D Hercher

Biomolecules (MDPI) Austria, Germany, 12 June 2022

Neuroscience

Key words: peripheral nerve regeneration, lymphangiogenesis, Schwann cells, lymphatic endothelial cells

Cell Line: Fibrin hydrogels containing Schwann cell, lymphatic endothelial cells and adipose-derived stem cells

217
Accumulation of Cytotoxic Skin Resident Memory T Cells and Increased Expression of IL-15 in Lesional Skin of Polymorphic Light Eruption

VK Patra, J Strobl, D Atzmüller, B Reininger, L Kleissl, A Gruber-Wackernagel, JF Nicolas, G Stary, M Vocanson, P Wolf

Frontiers in Medicine (Frontiers Media S.A.) France, Austria, 10 June 2022

Dermatology, Allergy Research

Key words: sun allergy, polymorphic light eruption, disease recurrence, inflammation, disease memory, resident memory T cell (TrM)

Organism: Human

Tissue: Skin

Pathological State: Polymorphic light eruption (PLE)

218
A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells

F Liang, LM Nilsson, F Byvald, A Rezapour, H Taflin, JA Nilsson, U Yrlid

Cancers (MDPI) Sweden, Australia, 10 June 2022

Oncology

Key words: colorectal liver metastases, tumor-infiltrating lymphocytes, tissue-resident memory T cells, patient-derived xenograft model, MEK inhibition

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

219
Long‐term outcomes of arterial ischemia or venous occlusion on vascularized groin lymph nodes in a rat model

CY Yang, IE Tinhofer, MH Cheng

Journal of Surgical Oncology (Wiley) Taiwan, Austria, 09 June 2022

Angiology

Key words: arterial ischemia, lymphedema, vascularized lymph node transfer, venous congestion

Organism: Rat

Tissue: Lymphoid Tissue

Pathological State: Arterial ischemia

220
Proteomic analysis of hepatic fibrosis induced by a high starch diet in largemouth bass (Micropterus salmoides)

X Wu, X Gu, M Xue, C Ge, X Liang

Comparative Biochemistry and Physiology Part D: Genomics and Proteomics (Elsevier) China, 08 June 2022

Zoology, Endocrinology

Key words: High starch diet, Hepatic fibrosis, Proteomics, PRM, Micropterus salmoides

Organism: Bass Fish

Tissue: Liver

Pathological State: Hepatic fibrosis

221
Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5

P Qiu, Y Jie, C Ma, H Chen, Y Qin, K Tu, L Wang, Z Zhang

Cell Death Discovery (Nature) China, 07 June 2022

Oncology

Key words: Cancer, Oncogenesis

Organism: Human

Tissue: Uterus

Pathological State: Cancer

222
Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses

X Cai, Z Zhou, J Zhu, X Liu, G Ouyang, J Wang, Z Li, X Li, H Zha, C Zhu, F Rong, J Tang, Q Liao, X Chen, W Xiao

Cell Reports (Cell Press) China, 07 June 2022

Immunology

Key words: OTUD3, RIG-I, MDA5, cGAS, deubiquitination, innate immunity

Organism: Mouse

Tissue: Lung

Pathological State: Virus Infection

223
Loss of core-fucosylation of SPARC impairs collagen binding and contributes to COPD

TJ Wu, SH Wang, ESW Chen, HH Tsai, YC Chang, YH Tseng, J Yu

Cellular and Molecular Life Sciences (Springer) Taiwan, 07 June 2022

Pulmonology

Key words: COPD, Fut8, Core-fucosylation, SPARC, Matricellular protein, Collagen

Organism: Human

Tissue: Lung

Pathological State: Chronic obstructive pulmonary disease

224
Diffusion tensor imaging reveals brain structure changes in dogs after spinal cord injury

CB Liu, DG Yang, J Li, C Qin, X Zhang, J Liu, DP Li, JJ Li

Neural Regeneration Research (Publishing House of Neural Regeneration Research) China, 06 June 2022

Neuroscience

Key words: spinal cord injury, diffusion tensor imaging, canines, pathophysiology, cerebrospinal structures, corticospinal tract, magnetic resonance imaging, anisotropic fraction, apparent dispersion coefficient

Organism: Dog

Tissue: Brain

Pathological State: Spinal cord injury

225
Fecal Microbiota Transfer Attenuates Gut Dysbiosis and Functional Deficits After Traumatic Brain Injury

BT Davis, Z Chen, MBAR Islam, ME Timken, D Procissi, SJ Schwulst

Shock (Wolters Kluwer) USA, 06 June 2022

Neuroscience, Gastroenterology

Key words: Traumatic brain injury, fecal microbiome transplantation, microbiome, dysbiosis, trauma, controlled cortical impact, behavior, anxiety

Organism: Mouse

Tissue: Brain

Pathological State: Traumatic Brain Injury

226
FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1

Q Yang, F Wu, Y Zhang, R Wang

Journal of Cellular and Molecular Medicine (Wiley) China, 03 June 2022

Oncology

Key words: FOXM1, glycolysis, nasopharyngeal carcinoma, PDK1, proliferation

Organism: Human

Tissue: Nasal Mucosa

Pathological State: Cancer

227
A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer

JN Zhou, B Zhang, HY Wang, DX Wang, MM Zhang, M Zhang, XK Wang, SY Fan, YC Xu, Q Zeng, YL Jia, JF Xi, X Nan, LJ He, XB Zhou, S Li, W Zhong, W Yue, XT Pei

Advanced Biology (Wiley) China, 02 June 2022

Oncology

Organism: Human

Cell Line: HCC cells

228
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma

X Huang, Y Huang, Z Lv, T Wang, H Feng, H Wang, S Du, S Wu, D Shen, C Wang, H Li, B Wang, X Ma, X Zhang

International Journal of Oncology (Spandidos Publications) China, 31 May 2022

Oncology

Organism: Human

Tissue: Kidney

Pathological State: Cancer

229
Ultra-Fine Polyethylene Hernia Meshes Improve Biocompatibility and Reduce Intraperitoneal Adhesions in IPOM Position in Animal Models

MJ Helmedag, D Heise, RM Eickhoff, SM Schmitz, M Mechelinck, C Emonts, T Bolle, T Gries, UP Neumann, CD Klink, A Lambertz

Biomedicines (MDPI) Germany, 31 May 2022

Tissue Engineering

Key words: polyethylene mesh, biocompatibility, IPOM, ultrafine diameter filaments, adhesion formation, animal trials

Tissue: Surgical mesh

230
Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice

C Liu, S Zhang, H Shi, H Zhou, J Zhuang, Y Cao, N Ward, J Wang

Brain Sciences (MDPI) China, USA, 30 May 2022

Neuroscience, Gastroenterology

Key words: microbiota-gut-brain axis, brain aging, gut microbiota, Atp11b, aging pathology

Organism: Mouse

Tissue: Brain

231
Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

R Liu, J Li, Y Xu, Z Chen, H Ye, J Tang, L Wei, L Liang

Investigative Ophthalmology & Visual Science (ARVO Journals) China, 26 May 2022

Ophthalmology

Organism: Human

Tissue: Meibomian Gland

232
Catalpol Attenuates Pulmonary Fibrosis by Inhibiting Ang II/AT1 and TGF-β/Smad-Mediated Epithelial Mesenchymal Transition

Q Yu, D Zhu, Y Zou, K Wang, P Rao, Y Shen

Frontiers in Medicine (Frontiers Media S.A.) China, 24 May 2022

Pulmonology

Key words: idiopathic pulmonary fibrosis, Ang II, TGF-β/Smad signaling pathway, EMT, catalpol

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

233
Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

R Ghiarasim, CE Tiron, A Tiron, MG Dimofte, M Pinteala, A Rotaru

Nanomaterials (MDPI) Romania, 24 May 2022

Nanomedicine

Key words: polyhistidine copolymers, micelles, doxorubicin, tumor cells, release studies

Cell Line: Micelles

234
Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma

P Chuntova, A Yamamichi, T Chen, R Narayanaswamy, S Ronseaux, C Hudson, AE Tron, ML Hyer, M Montoya, AL Mende, T Nejo, KM Downey, D Diebold, M Lu, B Nicolay, H Okada

Journal for ImmunoTherapy of Cancer (BMJ Journals) USA, 23 May 2022

Oncology, Immunology

Key words: Brain Neoplasms, Central Nervous System Neoplasms, Drug Evaluation, Preclinical, Programmed Cell Death 1 Receptor, Vaccination

Organism: Human

Cell Line: DTG-IDH1 cells

235
Tumor acidity-responsive polymeric nanoparticles to promote intracellular delivery of zoledronic acid by PEG detachment and positive charge exposure for enhanced antitumor potency

YH Chou, YL Liu, TC Hsu, JL Yow, BS Tzang, WH Chiang

Journal of Materials Chemistry B (Royal Society of Chemistry) Taiwan, 23 May 2022

Nanomedicine

Key words: Endocrinology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

236
Adverse Effects of Single Neutrophil Extracellular Trap-Derived Components on Bovine Sperm Function

C Moya, R Rivera-Concha, F Pezo, P Uribe, M Schulz, R Sánchez, C Hermosilla, A Taubert, U Gärtner, F Zambrano

Animals (MDPI) Chile, Germany, 20 May 2022

Reproductive Medicine, Zoology

Key words: bovine, spermatozoon, bull, neutrophil extracellular traps, membrane integrity

Organism: Cattle

Cell Line: polymorphonuclear neutrophils, Spermatozoa

237
Topography-Mediated Enhancement of Nonviral Gene Delivery in Stem Cells

L Ge, L Yang, R Bron, P van Rijn

Pharmaceutics (MDPI) China, The Netherlands, 20 May 2022

Pharmacology

Key words: topography, proliferation, gene delivery, endocytosis, transfection

Organism: Human

Cell Line: hBM-MSCs

238
Di-(2-ethylhexyl) Phthalate Promotes Allergic Lung Inflammation by Modulating CD8α+ Dendritic Cell Differentiation via Metabolite MEHP-PPARγ Axis

HH Tseng, CY Li, ST Wu, HH Su, TH Wong, HE Wu, YW Chang, SK Huang, EM Tsai, JL Suen

Frontiers in Immunology (Frontiers Media S.A.) Taiwan, USA, 19 May 2022

Immunology

Key words: allergic lung inflammation, dendritic cell, PPAR γ, low-dose exposure, di-(2-ethylhexyl) phthalate, mono-(2-ethylhexyl) phthalate (MEHP)

Organism: Mouse

Tissue: Lung

Pathological State: Allergic Lung Inflammation

239
Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts

X Li, T Yong, Z Wei, N Bie, X Zhang, G Zhan, J Li, J Qin, J Yu, B Zhang, L Gfan, X Yang

Nature Communications (Nature) China, 19 May 2022

Oncology

Key words: Cancer immunotherapy, Cancer therapeutic resistance, Drug delivery

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

240
Concurrent Germline and Somatic Mutations in FLCN and Preliminary Exploration of Its Function: A Case Report

T Wang, Y Yang, H Feng, B Cui, Z Lv, W Zhao, X Zhang, X Ma

Frontiers in Oncology (Frontiers Media S.A.) China, 19 May 2022

Oncology

Key words: Birt-Hogg-Dube (BHD) syndrome, folliculin (FLCN), mutation, renal cancer, TFEB/TFE3

Organism: Human

Tissue: Kidney

Pathological State: Cancer

241
Combination neoantigen-based dendritic cell vaccination and adoptive T-cell transfer induces antitumor responses against recurrence of hepatocellular carcinoma

S Peng, S Chen, W Hu, J Mei, X Zeng, T Su, W Wang, Z Chen, H Xiao, Q Zhou, B Li, Y Xie, H Hu, M He, Y Han, L Tang, Y Ma, X Li, X Zhou, Z Dai, Z Liu, J Tan, L Xu, S Li, S Shen, D Li, J Lai, B Peng, Z Peng, M Kuang

Cancer Immunology Research (AACR Publications) China, 18 May 2022

Oncology, Immunology

Organism: Human

Tissue: Liver

Pathological State: Cancer

242
Adenosine ameliorated Aβ25− 35-induced brain injury through the inhibition of apoptosis and oxidative stress via an ERα pathway

M Zeng, A Feng, C Zhao, B Zhang, P Guo, M Liu, Q Zhang, Y Zhang, R Fan, J Lyu, X Zheng

Brain Research (Elsevier) China, 18 May 2022

Neuroscience

Key words: Adenosine, Brain injury, ERα, Apoptosis, Oxidative stress

Organism: Mouse

Tissue: Brain

Pathological State: Brain injury

243
Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

M Schepelmann, M Ranieri, I Lopez-Fernandez, TS Webberley, SC Brennan, PL Yarova, J Graca, UK Hanif, C Müller, T Manhardt, M Salzmann, H Quasnichka, SA Price, DT Ward, T Gilbert, VV Matchkov, RA Fenton, A Herberger, J Hwong, C Santa Maria, CL Tu, E Kallay, G Valenti, W Chang, D Riccardi

Journal of The American Society of Nephrology (ASN) UK, Austria, Italy, Australia, USA, France, Denmark, 17 May 2022

Endocrinology

Key words: calcium-sensing receptor, mineral metabolism, vascular calcification, hypercalcemia, transgenic mouse, vascular smooth muscle

Organism: Mouse

Tissue: Kidney

244
Downregulated ADAMTS1 Incorporating A2M Contributes to Tumorigenesis and Alters Tumor Immune Microenvironment in Lung Adenocarcinoma

HC Lee, CY Chang, YC Huang, KL Wu, HH Chiang, YY Chang, LX Liu, JY Hung, YL Hsu, YY Wu, YM Tsai

Biology (MDPI) Taiwan, 16 May 2022

Oncology

Key words: A2M, ADAMTS1, EMT, immunity, LUAD, metastasis

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

245
Organ‐specific immune response in lethal SARS‐CoV‐2 infection by deep spatial phenotyping

A Balachander, B Lee, SK Biswas, DC Lye, RTP Lin, YS Leo, P Chui, LFP Ng, L Renia

Clinical & Translational Immunology (Wiley) Singapore, 15 May 2022

SARS-CoV-2, Immunology

Key words: COVID-19, immunopathology, in situ spatial multiplexing, SARS-CoV-2 infection

Organism: Human

Tissue: Lung, Small Intestine, Heart

Pathological State: COVID-19

246
Translocon-associated protein subunit SSR3 determines and predicts susceptibility to paclitaxel in breast cancer and glioblastoma

C Dmello, A Sonabend, VA Arrieta, DY Zhang, D Kanojia, L Chen, A Gould, J Zhang, SJ Kang, J Winter, C Horbinski, C Amidel, B Győrffy, A Cordero, C Lee-Chang, B Castro, P Hsu, AU Ahmend, MS Lesniak, R Stupp, AM Sonabend

Clinical Cancer Research (AACR Publications) USA, Germany, Hungary, 12 May 2022

Oncology

Key words: Paclitaxel, biomarker, glioblastoma, breast cancer, SSR3

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

247
Novel Elastic Threads for Intestinal Anastomoses: Feasibility and Mechanical Evaluation in a Porcine and Rabbit Model

SM Schmitz, MJ Helmedag, KM Kossel, RM Eickhoff, D Heise, A Kroh, M Mechelinck, T Gries, S Jockenhoevel, UP Neumann, A Lambertz

International Journal of Molecular Sciences (MDPI) Germany, The Netherlands, 11 May 2022

Tissue Engineering

Key words: biomaterial, TPU, surgical thread, suture material, elastic suture, gastrointestinal anastomosis

248
Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG4-related disease and Kimura disease

R Munemura, T Maehara, Y Murakami, R Koga, R Aoyagi, N Kaneko, A Doi, CA Perugino, E Della-Torre, T Saeki, Y Sato, H Yamamoto, T Kiyoshima, JH Stone, S Pillai, S Nakamura

Journal of Allergy and Clinical Immunology (Elsevier) Japan, USA, Italy, 11 May 2022

Immunology

Key words: Single-cell RNA sequencing, IgG4-related disease, IgG4-RD, IgG4, IgE, Tfh cell, B cell, interleukin-10, class switch, fibrosis

Organism: Human

Tissue: Salivary Gland

Pathological State: IgG4-related disease and Kimura disease

249
In vitro testicular toxicity of environmentally relevant endocrine-disrupting chemicals: 2D vs. 3D models of prepubertal Leydig TM3 cells

E Sychrová, A Yawer, P Labohá, A Basu, A Dydowiczová, I Virmani, P Babica, I Sovadinová

Environmental Toxicology and Pharmacology (Elsevier) Czech Republic, 10 May 2022

Reproductive Medicine, Toxicology

Key words: 3D in vitro models, Endocrine-disrupting chemicals, Leydig cells, Lipotoxicity, Reproductive toxicity, Spheroids

Tissue: Spheroid

Cell Line: Leydig TM3 cells

250
AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice—A Pilot Study

M Schepelmann, N Kupper, V Gushchina, I Mesteri, T Manhardt, S Moritsch, S Müller, K Piatek, M Salzman, A Vlasaty, R Eferl, E Kallay

International Journal of Molecular Sciences (MDPI) Austria, Germany, 09 May 2022

Oncology, Gastroenterology

Key words: aged mice, colitis associated colorectal cancer, AOM, DSS, mouse strain differences, pilot study

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

251
Hybrid PEGylated chitosan/PLGA nanoparticles designed as pH-responsive vehicles to promote intracellular drug delivery and cancer chemotherapy

SJ Huang, TH Wang, YH Chou, HMD Wang, TC Hsu, JL Yow, BS Tzang, WH Chiang

International Journal of Biological Macromolecules (Elsevier) Taiwan, 05 May 2022

Nanomedicine, Oncology

Key words: Acidity-responsive nanovehicles, PEGylated chitosan, cancer chemotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

252
Multinucleated Retinal Pigment Epithelial Cells Adapt to Vision and Exhibit Increased DNA Damage Response

Q Ke, L Gong, X Zhu, R Qi, M Zou, B Chen, W Liu, S Huang, Y Liu, DWC Li

Cells (MDPI) China, 05 May 2022

Key words: multinucleation, retinal pigment epithelium, reactive oxygen species, photoreceptor, DNA damage, p53

Organism: Mouse

Tissue: Eye

253
Macrophage-associated immune checkpoint CD47 blocking ameliorates endometriosis

J Li, S Yan, Q Li, Y Huang, M Ji, X Jiao, M Yuan, G Wang

Molecular Human Reproduction (Oxford Academic) China, 05 May 2022

Reproductive Medicine

Key words: apoptosis, endometriosis, immune checkpoint, immunotherapy, macrophage, phagocytosis

Organism: Human

Tissue: Endometrium

Pathological State: Endometriosis

254
DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide

MT Latancia, NC Moreno, GS Leandro, V Chaves Ribeiro, I de Souza, W Kleber Martins Vieira, A Uchimura Bastos, NC Hoch CRR Rocha, CFM Menck

Mutation Research/Genetic Toxicology and Environmental Mutagenesis (Elsevier) Brazil, 05 May 2022

Toxicology

Key words: XP-V, Temozolomide, Polymerase eta, DNA damage, Translesion synthesis, Cisplatin

Organism: Human

Cell Line: TLS-deficient cell line XP30RO

255
miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization

N Li, X Wang, J Sun, Y Liu, A Han, Z Lin, Y Yang

Carcinogenesis (Oxford Academic) China, 02 May 2022

Oncology

Key words: Tiam1, breast cancer, metastasis, glucose metabolism reprogramming, miR-21-5p

Organism: Human

Cell Line: BC cell lines

256
SAM and folic acid prevent arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells by modulating expression of inflammatory and DNA repair genes

T Boonma, P Navasumrit, V Parnlob, S Waraprasita, M Ruchirawatac

Chemico-Biological Interactions (Elsevier) Thailand, 02 May 2022

Toxicology

Key words: Arsenic, S-adenosyl methionine (SAM), Folic acid, DNA methylation, 8-hydroxydeoxyguanosine (8-OHdG), 8-nitroguanine

Organism: Human

Cell Line: Lymphoblast cells (RPMI 1788)

257
Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse

W Huang, Q Xu, F Liu, J Su, D Xiao, L Tang, ZZ Hao, R Liu, K Xiang, Y Bi, Z Miao, X Liu, Y Liu, S Liu

Investigative Ophthalmology & Visual Science (ARVO Journals) China, UK, 02 May 2022

Ophthalmology, Neuroscience

Organism: Mouse

Tissue: Eye

258
ITGB1 Suppresses Autophagy Through Inhibiting The mTORC2/AKT Signaling Pathway In H9C2 Cells

W Zhou, W Liu, D Zhou, A Li

Die Pharmazie-An International Journal of Pharmaceutical Sciences (Avoxa - Mediengruppe Deutscher Apotheker GmbH) China, 01 May 2022

Pharmacology

Organism: Rat

Tissue: Heart

259
Prognostic Value of Characterizing Myocardial Tissue by Cardiac MRI with T1 Mapping in HFpEF Patients: A Systematic Review and Meta-Analysis

E Golukhova, N Bulaeva, S Alexandrova, O Gromova, B Berdibekov

Journal of Clinical Medicine (MDPI) Russia, 30 April 2022

Cardiology

Key words: cardiac MRI, HFpEF, T1 mapping, extracellular volume, native T1, postcontrast T1, prognosis

260
The Overexpression of Insulin-Like Growth Factor-1 and Neurotrophin-3 Promote Functional Recovery and Alleviate Spasticity After Spinal Cord Injury

Z Talifu, C Qin, Z Xin, Y Chen, J Liu, S Dangol, X Ma, H Gong, Z Pei, Y Yu, J Li, L Du

Frontiers in Neuroscience (Frontiers Media S.A.) China, 29 April 2022

Neuroscience

Key words: spinal cord injury, nerve repair, nerve growth factor, NT-3, IGF-1, motor function recovery, spasticity, mechanical pain

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

261
Epidermotropism of inflammatory cells differentiates pyoderma gangrenosum from venous leg ulcers

M Ronicke, A Baur, M Kirr, M Erdmann, C Erfurt-Berge, C Ostalecki

Journal of the German Society of Dermatology (Wiley) Germany, 29 April 2022

Dermatology

Organism: Human

Tissue: Skin

Pathological State: Ulcer

262
Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model

JF Fu, CJ Wen, TH Yen, LY Shih

Neoplasia (Elsevier) Taiwan, 29 April 2022

Oncology

Key words: MLL translocation, KRAS mutation, Hoxa11, Hoxa10, Myeloid sarcoma, Migration

Organism: Mouse

Cell Line: Mouse MLL/AF10 leukemia cell lines

263
Prognostic values of B7-H3, B7-H4, and HHLA2 expression in human pancreatic cancer tissues based on mIHC and spatial distribution analysis

Y Zhu, J Chen, Y Liu, X Zheng, J Feng, X Chen, T Jiang, Y Li, L Chen

Pathology-Research and Practice (Elsevier) China, 29 April 2022

Oncology

Key words: B7-H3, B7-H4, HHLA2, Multi-color immunohistochemistry, Prognosis, Pancreatic cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

264
PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

X Tan, J Bednarsch, M Rosin, S Appinger, D Liu, G Wiltberger, J Garcia Vallejo, SA Lang, Z Czigany, S Boroojerdi, NT Gaisa, P Boor, RD Bülow, J De Vos-Geelen, L Valkenburg-van Iersel, MC Clahsen-van Groningen, EJM de Jong, BG Koerkamp, M Doukas, FG Rocha, T Luedde, U Klinge, S Sivakumar, UP Neumann, LR Heij

Cancers (MDPI) Germany, The Netherlands, USA, UK, 27 April 2022

Oncology

Key words: cholangiocarcinoma, liver cancer, tumor microenvironment, nerve fiber density, immune checkpoint, immune cells

Organism: Human

Tissue: Bile duct

Pathological State: Cancer

265
Corallodiscus flabellata BL Burtt extract and isonuomioside A ameliorate Aβ25− 35-induced brain injury by inhibiting apoptosis, oxidative stress, and autophagy via the NMDAR2B/CamK Ⅱ/PKG pathway

M Zeng, A Feng, M Li, M Liu, P Guo, Y Zhang, Q Zhang, B Zhang, B Cao, J Jia, R Wang, J Lyu, X Zheng

Phytomedicine (Elsevier) China, 27 April 2022

Toxicology

Key words: Isonuomioside A, Corallodiscus flabellata B. L. Burtt extract, NMDAR2B, Apoptosis, Oxidative stress, Autophagy

Organism: Mouse

Tissue: Brain

266
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target

BC Moraes, HV Ribeiro-Filho, AP Roldão, EF Toniolo, GPB Carretero, GG Sgro, FAH Batista, DE Berardi, VRS Oliveira, R Tomasin, FM Vieceli, DT Pramio, AB Cardoso, ACM Figueira, SC Farah, LA Devi, CS Dale, PSL de Oliveira, D Schechtman

Science Signaling (Science) Brazil, USA, 26 April 2022

Pharmacology

267
Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site

Y Jing, F Bai, L Wang, D Yang, Y Yan, Q Wang, Y Zhu, Y Yu, Z Chen

Microbiology Spectrum (ASM Journals) China, 25 April 2022

Microbiology, Neuroscience

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

268
Oxidative Stress-Induced Growth Inhibitor (OSGIN1), a Target of X-Box-Binding Protein 1, Protects Palmitic Acid-Induced Vascular Lipotoxicity through Maintaining Autophagy

CS Khoi, CQ Xiao, KY Hung, TY Lin, CK Chiang

Biomedicines (MDPI) Taiwan, 25 April 2022

Cell Biology

Key words: palmitic acid, OSGIN1, unfolded protein response, XBP1s, autophagy, eNOS, endothelial cells

Organism: Human

Tissue: Blood Vessels

Pathological State: Atherosclerosis

269
HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

X Lu, K Fong, G Gritsina, F Wang, SC Baca, LT Brea, JE Berchuck, S Spisak, J Ross, C Morrissey, E Corey, NS Chandel, WJ Catalona, X Yang, ML Freedman, JC Zhao, J Yu

Nature Genetics (Nature) USA, 25 April 2022

Oncology

Key words: Epigenomics, Prostate cancer, Targeted therapies

Organism: Human

Tissue: Prostate

Pathological State: Cancer

270
HLA class I downregulation in progressing metastases of melanoma patients treated with ipilimumab

A Ladányi, B Hegyi, T Balatoni, G Liszkay, R Rohregger, C Waldnig, J Dudás, S Ferrone

Pathology and Oncology Research (Elsevier) Hungary, Austria, USA, 22 April 2022

Oncology

Key words: immunotherapy, melanoma, ipilimumab, HLA class I expression, longitudinal study

Organism: Human

Tissue: Skin

Pathological State: Cancer

271
Increased fatty acid metabolism attenuates cardiac resistance to β-adrenoceptor activation via mitochondrial reactive oxygen species: A potential mechanism of hypoglycemia-induced myocardial injury in diabetes

L Huang, Z Chen, R Chen, L Lin, L Ren, M Zhang, L Liu

Redox Biology (Elsevier) China, 21 April 2022

Endocrinology

Key words: Hypoglycemia, Diabetes, Lipid metabolism, β-adrenoceptor, Mitochondrial reactive oxygen species

Organism: Mouse

Tissue: Heart

272
CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by

C Liu, X Cheng, J Xing, J Li, Z Li, D Jian, Y Wang, S Wang, R Li, W Zhang, D Shao, X Ma, X Chen, J Shen, C Shi, Z Gao, W Wang, T Fan, L Liu, H Tang

International Journal of Biological Sciences (Ivyspring International Publisher) China, 20 April 2022

Cardiology, Oncology

Key words: CIRBP, Cardioprotection, OGFR, Chemotherapy-induced cardiotoxicity, Cardiomyocyte apoptosis

Organism: Mouse

Tissue: Heart

273
CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis

DW Zhang, JJ Ye, Y Sun, S Ji, JY Kang, YY Wei, GH Fei

Journal of Inflammation Research (Dovepress) China, 20 April 2022

Pulmonology

Key words: chronic obstructive pulmonary disease, emphysema, B cell, bioinformatics analysis

Organism: Human

Tissue: Lung

Pathological State: Chronic obstructive pulmonary disease

274
Endocrine-disrupting chemicals affect sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro

A Yawer, E Sychrová, J Raška, P Babica, I Sovadinová

Food and Chemical Toxicology (Elsevier) Czech Republic, 19 April 2022

Reproductive Medicine

Key words: Connexins, Endocrine-disrupting chemicals, Gap junctional intercellular communication, Reproductive toxicity, Sertoli cells, Testicular tumors

Organism: Human

Cell Line: Sertoli TM4 cells

275
Computer-assisted evaluation enhances the quantification of interstitial fibrosis in renal implantation biopsies, measures differences between frozen and paraffin sections, and predicts delayed graft function

M Pavlovic, A Oszwald, Ž Kikić, MC Nackenhorst, R Kain, N Kozakowski

Journal of Nephrology (Springer) Austria, France, 19 April 2022

Medical Image Analysis

Key words: Implantation biopsy, Interstitial fibrosis, Computer-assisted evaluation, Delayed graft function

Organism: Human

Tissue: Kidney

Pathological State: Interstitial fibrosis

276
Robust delivery of RIG‐I agonists using extracellular vesicles for anti‐cancer immunotherapy

B Peng, TM Nguyen, MK Jayasinghe, C Gao, TT Pham, LT Vu, EYM Yeo, G Yap, L Wang, BC Goh, WL Tam, D Luo, MTN Le

Journal of Extracellular Vesicles (Wiley) Singapore, 16 April 2022

Oncology

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

277
Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging

N Mori, C Inoue, H Tamura, T Nagasaka, H Ren, S Sato, Y Mori, M Miyashita, S Mugikura, K Takase

Magnetic Resonance Imaging (Elsevier) Japan, 16 April 2022

Medical Imaging

Key words: Breast cancer, Magnetic resonance imaging, Diffusion weighted imaging, Diffusion kurtosis imaging, Histology

Organism: Human

Tissue: Breast

Pathological State: Cancer

278
The significance of NAD+ metabolites and nicotinamide N-methyltransferase in chronic kidney disease

R Takahashi, T Kanda, M Komatsu, T Itoh, H Minakuchi, H Urai, T Kuroita, S Shigaki, T Tsukamoto, N Higuchi, M Ikeda, R Yamanaka, N Yoshimura, T Ono, H Yukioka, K Hasegawa, H Tokuyama, S Wakino, H Itoh

Scientific Reports (Nature) Japan, 16 April 2022

Nephrology

Key words: Medical research, Nephrology

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

279
Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway

Y Sun, Y Qian, C Chen, H Wang, X Zhou, W Zhai, L Qiu, X Zhou, H Ning, Y Zhao, C Shi, L Han, Y Qi, Y Wu, Y Gao

Journal of Experimental & Clinical Cancer Research (BMC) China, 15 April 2022

Oncology

Key words: Esophageal squamous cell carcinoma, IL-32, Extracellular vesicle, M2 macrophage polarization, Metastasis

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

280
Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice

YH Mao, Y Xu, F Song, ZM Wang, YH Li, M Zhao, F He, Z Tian, Y Yang

Carbohydrate Polymers (Elsevier) China, 14 April 2022

Gastroenterology

Key words: Polysaccharides, Molecular weight, Prebiotic fiber, Protection, Dysbiosis

Organism: Mouse

Tissue: Colon

Pathological State: Dysbiosis

281
AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia

E Gonçalves-Alves, M Garcia, CJ Rodríguez-Hernández, S Gómez-González, R Ecker, M Suñol, O Muñoz-Aznar, AM Carcaboso, J Mora, C Lavarino, S Mateo-Lozano

International Journal of Molecular Sciences (MDPI) Spain, Austria, 13 April 2022

Oncology

Key words: neuroblastoma, calcium-sensing receptor, calcimimetic, cinacalcet, AC-265347, biased signaling, differentiation, cancer-testis antigens

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

282
A phase 1b study of OXIRI in pancreatic adenocarcinoma patients and its immunomodulatory effects

M Ng, S Chen, WS Ong, A Balachander, A Seet, J Yeong, N Sutiman, TKH Lim, B Lee, YA Guo, WF Leong, SS Lee, J Lam, SP Choo, AJ Skanderup, SK Biswas, D Tai, B Chowbay

International Journal of Cancer (Wiley) Singapore, 12 April 2022

Oncology

Key words: PDAC, OXIRI, metronomic oxaliplatin, chronomodulated capecitabine, UGT1A1, irinotecan

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

283
Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy

H Kong, H Zhao, T Chen, Y Song, Y Cui

Cell Death & Disease (Nature) China, 12 April 2022

Ophthalmology

Key words: Apoptosis, Cell death

Organism: Mouse

Tissue: Eye

Pathological State: Diabetes, Retinopathy

284
Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome

P Guo, M Zeng, S Wang, B Cao, M Liu, Y Zhang, J Jia, Q Zhang, B Zhang, R Wang, X Zheng, W Feng

Molecules (MDPI) China, 12 April 2022

Neuroscience

Key words: eriodictyol, homoeriodictyol, NLRP3 inflammasome, Alzheimer’s disease, Aβ25–35

Organism: Mouse

Tissue: Brain

285
Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy

MK Jayasinghe, M Pirisinu, Y Yang, B Peng, TT Pham, CY Lee, M Tan, L Tien Vu, XTT Dang, TC Pham, H Chen, AYH Leung, WC Cho, J Shi, MTN Le

Theranostics (Ivyspring International Publisher) Singapore, Hong Kong, China, 11 April 2022

Oncology

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

286
ERBB2D16 Expression in HER2 Positive Gastric Cancer Is Associated With Resistance to Trastuzumab.

S Wang, Y Zhao, Y Song, G Qiao, Y Di, J Zhao, P Sun, H Zheng, H Huang, H Huang

Frontiers in Oncology (Frontiers Media S.A.) China, 07 April 2022

Oncology

Key words: gastric cancer, ERBB2d16, epithelial-mesenchymal transition, immunosuppression, trastuzumab resistance

Organism: Human

Tissue: Stomach

Pathological State: Cancer

287
Rho kinase inhibition ameliorates vascular remodeling and blood pressure elevations in a rat model of apatinib-induced hypertension

C Li, L Ma, Q Wang, X Shao, L Guo, J Chen, W Wang, J Yu

Journal of Hypertension (Wolters Kluwer) China, 07 April 2022

Cardiology

Key words: RhoA/Rho-associated coiled-coil domain-containing protein kinase signaling pathway, apatinib, hypertension, tyrosine kinase inhibitors, vascular endothelial growth factor

288
Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis

G Zhang, Q Wang, W Tao, W Jiang, E Elinav, Y Wang, S Zhu

Nature Biomedical Engineering (Nature) China, Israel, 07 April 2022

Nanomedicine, Gastroenterology

289
Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice

C Huang, Y Wang, P Chen, QH Shan, H Wang, LF Ding, GQ Bi, JN Zhou

Communications Biology (Nature) China, 06 April 2022

Neuroscience

Key words: 3-D reconstruction, Fluorescence imaging, Light-sheet microscopy, Neural circuits, Viral tracing

Organism: Mouse

Tissue: Brain

290
Inhibition of CXXC5 function reverses obesity‐related metabolic diseases

SH Seo, E Kim, SH Lee, Y Lee, DH Han, H Go, JK Seong, KY Choi

Clinical and Translational Medicine (Wiley) South Korea, 05 April 2022

Endocrinology

Organism: Mouse

Tissue: Pancreas

Pathological State: Obesity

291
Inhibiting MNK kinases promotes macrophage immunosuppressive phenotype to limit CD8+ T cell anti-tumor immunity

TND Pham, C Spaulding, MA Shields, AE Metropulos, DN Shah, MG Khalafalla, DR Principe, DJ Bentrem, HG Munshi

JCI Insight (American Society for Clinical Investigation) USA, 05 April 2022

Immunology, Oncology

Key words: MNK kinases, tumor-associated macrophages, CD8+ T cells, immunotherapy, antiPD-1 antibody, anti-CSF-1R antibody, pancreatic cancer, thyroid cancer

Organism: Human

Tissue: Thyroid

292
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

CC Gao, M Li, W Deng, CH Ma, YS Chen, YQ Sun, T Du, QL Liu, WJ Li, B Zhang, L Sun, SM Liu, F Li, F Qi, Y Qu, X Ge, J Liu, P Wang, Y Niu, Z Liang, YL Zhao, B Huang, XZ Peng, Y Yang, C Qin, WM Tong, YG Yang

Protein & cell (Springer) China, 04 April 2022

SARS-CoV-2, Immunology

Key words: SARS-CoV-2, NRP1, inflammation, central nervous system, viral encephalitis, rhesus macaque

Organism: Rhesus Macaques

Tissue: Lung

Pathological State: COVID-19

293
KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion

X Han, C Wang, L Song, X Wang, S Tang, T Hou, C Liu, X Liang, C Qiu, Y Wang, Y Du

EBioMedicine (Elsevier) China, Sweden, 01 April 2022

Cell Biology, Neuroscience

Key words: Extracellular vesicles, Lysosomes, KIBRA, Amyloid β, Alzheimer's disease

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

294
Extracellular Vesicles Derived from SIPA1high Breast Cancer Cells Enhance Macrophage Infiltration and Cancer Metastasis through Myosin-9

L Feng, J Weng, C Yao, R Wang, N Wang, Y Zhang, Y Tanaka, L Su

Biology (MDPI) China, Japan, 31 March 2022

Oncology

Key words: breast cancer, extracellular vesicles, macrophage, myosin-9, SIPA1

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

295
Prenatal infection predisposes offspring to enhanced susceptibility to imiquimod-mediated psoriasiform dermatitis in mice

S Yu, CW Lee, YA Li, TH Chen, HS Yu

Dermatologica Sinica (Taiwanese Society for Investigative Dermatology) Taiwan, 30 March 2022

Dermatology

Key words: Bacterial infection, lipopolysaccharide, polyinosinic:polycytidylic acid, psoriasis, psoriatic arthritis, viral infection

Organism: Mouse

Tissue: Skin

Pathological State: Psoriasis

296
Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19

N Kaneko, J Boucau, HH Kuo, C Perugino, VS Mahajan, JR Farmer, H Liu, TJ Diefenbach, A Piechocka-Trocha, K Lefteri, MT Waring, KR Premo, BD Walker, JZ Li, G Gaiha, XG Yu, M Lichterfeld, RF Padera Jr, S Pillai

Clinical Immunology (Elsevier) USA, Japan, 29 March 2022

SARS-CoV-2, Immunology

Key words: COVID-19, CD8+ T cells, Cytotoxic CD4+ T cells

Organism: Human

Tissue: Lung, Lymphoid Tissue

Pathological State: COVID-19

297
FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway

Y Zhang, Y Wang, G Zhao, EJ Tanner, M Adli, D Matei

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 29 March 2022

Oncology

Organism: Mouse

Tissue: Ovaries, Xenograft Tumor

Pathological State: Cancer

298
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration

M Zou, Q Ke, Q Nie, R Qi, X Zhu, W Liu, X Hu, Q Sun, JL Fu, X Tang, Y Liu, DWC LI, L Gong

Cell Death & Differentiation (Nature) China, 28 March 2022

Ophthalmology

Key words: Drug development, Epigenetics

Organism: Mouse

Tissue: Eye

299
Food Allergen Nitration Enhances Safety and Efficacy of Oral Immunotherapy in Food Allergy

N Samadi, L Koidl, M Salzmann, M Klems, N Komatitsch, D Schaffer, E Weidmann, A Duschi, J Horejs-Hoeck, E Untersmayr

Nutrients (MDPI) Austria, 25 March 2022

Allergy Research

Key words: oral immunotherapy, food allergy, protein nitration, modulated immune response

Organism: Mouse

Tissue: Stomach

Pathological State: Allergy

300
Effects of Magnetite Nanoparticles and Static Magnetic Field on Neural Differentiation of Pluripotent Stem Cells

AT Semeano, FA Tofoli, JC Corrêa-Velloso, AP de Jesus Santos, Á Oliveira-Giacomelli, RR Cardoso, MA Pessoa, E Lummertz da Rocha, G Ribeiro, MZR Ferrari, LV Pereira, YD Teng, DFS Petri, H Ulrich

Stem Cell Reviews and Reports (Springer) Brazil, USA, 24 March 2022

Stem Cell Research, Nanomedicine

Key words: Neural differentiation, Magnetic nanoparticles, Magnetic field, Biomagnetic effects, Embryonic stem cells, iPSCs, Dopaminergic neurons

Organism: Human

Cell Line: Induced dopaminergic neurons

301
Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells Mitigate Endoplasmic Reticulum Stress, Inflammation, and Lung Injury in Lipopolysaccharide-Treated Obese Mice

MD Chiang, CY Chang, HJ Shih, VL Le, YH Huang, CJ Huang

Antioxidants (MDPI) Taiwan, Vietnam, 23 March 2022

Endocrinology

Key words: lung injury, obesity, endoplasmic reticulum stress, exosomes, LPS

Organism: Mouse

Tissue: Lung

Pathological State: Obesity

302
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway

Y Li, H Liu, X Liu, B Xiao, M Zhang, Y Luo, M Li, J Yang

Frontiers in Oncology (Frontiers Media S.A.) China, 22 March 2022

Oncology, Pharmacology

Key words: gracillin, non-small cell lung cancer, autophagy, mTOR signaling pathway, anti-tumor

Organism: Mouse

Tissue: Heart, Liver, Kidney, Lung, Xenograft Tumor

Pathological State: Cancer

303
A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer

PH Chou, CK Luo, N Wali, WY Lin, SK Ng, CH Wang, M Zhao, SW Lin, PM Yang, PJ Liu, JJ Shie, TT Wei

Journal of Biomedical Science (BMC) Taiwan, USA, 22 March 2022

Oncology

Key words: STAT1, Colorectal cancer, Stemness, Angiogenesis, 4’,5,7-trihydroxyisoflavone (THIF), BODIPY-THIF

Organism: Human

Tissue: Colon

Pathological State: Cancer

304
Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model

H Scherthan, SQ Wagner, J Grundhöfer, N Matejka, J Müller, S Müller, S Rudigkeit, M Sammer, S Schoof, M Port, J Reindl

Cancers (MDPI) Germany, 17 March 2022

Radiotherapy

Key words: 53BP1, cell death, DNA damage, epidermis, γ-H2AX, proton minibeam radiation therapy, DNA repair, skin model

Organism: Human

Cell Line: Human reconstructed epidermis (epiCS®) models

305
Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis

M Wu, X Zhang, W Zhang, YS Chiou, W Qian, X Liu, M Zhang, H Yan, S Li, T Li, X Han, P Qian, S Liu, Y Pan, PE Lobie, T Zhu

Nature communications (Nature) China, Taiwan, 16 March 2022

Oncology

Key words: Breast cancer, Cancer stem cells, Cancer therapy, Metastasis, Tumour heterogeneity

Organism: Human

Tissue: Breast, Lymphoid Tissue

Pathological State: Cancer

306
Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway

J Lv, Y Liu, S Mo, Y Zhou, F Chen, F Cheng, C Li, D Saimi, M Liu, H Zhang, K Tang, J Ma, Z Wang, Q Zhu, WM Tong, B Huang

Nature Cell Biology (Nature) China, 15 March 2022

Oncology

Key words: Glycoproteins, Mechanisms of disease, Pancreatic cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

307
Regorafenib Reverses Temozolomide-Induced CXCL12/CXCR4 Signaling and Triggers Apoptosis Mechanism in Glioblastoma

I Chiang, YC Liu, HS Liu, AAA Ali, SY Chou, TI Hsu, FT Hsu

Neurotherapeutics (Springer) Taiwan, 10 March 2022

Oncology

Key words: Glioblastoma, Temozolomide, Regorafenib, NF-κB, CXCR4/CXCL12

Organism: Mouse

Tissue: Brain, Xenograft Tumor

Pathological State: Cancer

308
hsa-miR-875-5p inhibits tumorigenesis and suppresses TGF-β signalling by targeting USF2 in gastric cancer

S Gao, Z Zhang, X Wang, Y Ma, C Li, H Liu, C Jing, L Li, X Guo

Journal of Translational Medicine (Springer) China, 07 March 2022

Oncology

Key words: miR-875-5p, USF2, Gastric cancer, TGF-β

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

309
Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy

W Jiang, W Dong, M Li, Z Guo, Q Wang, Y Liu, Y Bi, H Zhou, Y Wang

ACS NANO (ACS Publications) China, 03 March 2022

Oncology

Key words: Nitric oxide, Immunogenic cell death, NO nanogenerator, Vaccination effects, PD-1 blockade therapy

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

310
Low miR-10b-3p associated with sorafenib resistance in hepatocellular carcinoma

YY Shao, PS Chen, LI Lin, BS Lee, A Ling, AL Cheng, C Hsu, DL Ou

British Journal of Cancer (Nature) Taiwan, USA, 02 March 2022

Oncology

Key words: Hepatocellular carcinoma, Tumour biomarkers

Organism: Mouse

Tissue: Liver, Xenograft Tumor

Pathological State: Cancer

311
Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

MA Shields, C Spaulding, AE Metropulos, MG Khalafalla, TND Pham, HG Munshi

Cell Reports (Cell Press) USA, 01 March 2022

Oncology

Key words: Gα13, KC mouse model, KPC mouse model, Human PDAC tumors, E-cadherin, mTOR, Rapamycin

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

312
Immunoarchitectural patterns as potential prognostic factors for invasive ductal breast cancer

X Du, Z Zhou, Y Shao, K Qian, Y Wu, J Zhang, M Cui, J Wang, S Wang, Y Tai

npj Breast Cancer (Nature) China, 28 February 2022

Oncology

Key words: Breast cancer, Prognostic markers

Organism: Human

Tissue: Breast

Pathological State: Cancer

313
EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma

J Ingruber, J Dudás, D Savic, G Schweigl, TB Steinbichler, M do Carmo Greier, M Santer, S Carollo, Z Trajanoski, H Riechelmann

Experimental Cell Research (Elsevier) Austria, 25 February 2022

Oncology

Key words: Mesenchymal-to-epithelial transition, Cell-transfection, TissueFax, UPCI-SCC090, SCC25, FaDu

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

314
Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus

JH Lee, C Ostalecki, T Oberstein, S Schierer, E Zinser, M Eberhardt, K Blume, B Plosnita, L Stich, H Bruns, R Coras, J Vera-Gonzales, M Maler, AS Baur

EBioMedicine (Elsevier) Germany, Austria, 25 February 2022

Neuroscience

Key words: Alzheimer's disease, Plasma extracellular vesicles, Choroid plexus, Hippocampus, Hyaluronan, Hyaluronic acid synthetase, Secretases, BACE, Aβ, APP

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

315
Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms

X Guo, X Jin, K Han, S Kang, S Tian, X Lv, M Feng, H Zheng, Y Zuo, G Xu, M Hu, J Xu, P Lv, YZ Chang

Free Radical Biology and Medicine (Elsevier) China, 24 February 2022

Neuroscience

Key words: Iron, Ischemic stroke, Gliosis, Synaptic plasticity, Myelination, Nerve regeneration

Organism: Mouse

Tissue: Brain

Pathological State: Stroke

316
Tumor Necrosis Factor-α Mediates Lung Injury in the Early Phase of Endotoxemia

KY Chen, CY Chang, HJ Hsu, HJ Shih, IT Huang, HH Patel, CJ Huang

Pharmaceuticals (MDPI) Taiwan, Australia, 24 February 2022

Pulmonology

Key words: lung injury, endotoxin, cytokines, cytokine receptors, peptide, mice

Organism: Mouse

Tissue: Lung

Pathological State: Endotoxemia

317
Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation

J Gao, H Mei, J Sun, H Li, Y Huang, Y Tang, L Duan, D Liu, Y Pang, Q Wang, Y Gao, K Song, J Zhao, C Zhang, J Liu

Advanced Biology (Wiley) China, Australia, 23 February 2022

SARS-CoV-2, Osteology

Organism: Human

Pathological State: SARS-CoV-2 Infection

Cell Line: Bone marrow cells

318
High farnesoid X receptor expression predicts favorable clinical outcomes in PD‑L1low/negative non‑small cell lung cancer patients receiving anti‑PD‑1‑based chemo‑immunotherapy

L Wang, X Xu, B Shang, J Sun, B Liang, X Wang, W You, S Jiang

International Journal of Oncology (Spandidos Publications) China, 23 February 2022

Oncology

Key words: Farnesoid X receptor, Predictor, anti‑PD‑1‑based, Chemo‑immunotherapy, Non‑small cell lung cancer, PD‑L1low/negative patients

Organism: Human

Tissue: Lung

Pathological State: Cancer

319
Prompt Antiviral Action of Pulmonary CD8+ TRM Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung

L Jiang, L Liu, M Zhang, L Zhang, C Zhu, Q He, L Ye, C Zhao, Z Li, J Xu, X Zhang

Frontiers in Immunology (Frontiers Media S.A.) China, 22 February 2022

Immunology

Key words: influenza, lung-resident memory CD8 T cells, IFN-γ, interferon-induced genes, inflammatory cytokines

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection

320
Meloxicam Inhibits Hepatocellular Carcinoma Progression and Enhances the Sensitivity of Immunotherapy via the MicroRNA-200/PD-L1 Pathway

S Guangshun, S Guoqiang, C Xin, K Xiangyi, Z Wubin, L Zhitao, Z Zhiying, C Hongyong, L Chengyu, X Yongxiang, T Weiwei

Journal of Oncology (Hindawi Publishing Corporation) China, 21 February 2022

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

321
TSPAN6 is a suppressor of Ras-driven cancer

PO Humbert, TZ Pryjda, B Pranjic, A Farrell, K Fujikura, R de Matos Simoes, R Karim, I Kozieradzki, SJF Cronin, GG Neely, TF Meyer, A Hagelkruys, HE Richardson, JM Penninger

Oncogene (Nature) Australia, Austria, Germany, Canada, 19 February 2022

Oncology

Key words: Cancer genetic, Cell polarity, Growth factor signalling

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

322
Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects

YH Chan, KN Ho, YC Lee, MJ Chou, WZ Lew, HM Huang, PC Lai, SW Feng

Stem Cell Research & Therapy (Springer) Taiwan, USA, 19 February 2022

Osteology

Key words: Melatonin, Dental pulp mesenchymal stem cells, Osteogenesis, COX2/NF-κB, p38/ERK signaling pathwaym, Bone regeneration, Calvarial bone defect

Organism: Rabbit

Tissue: Bone

323
The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

F Niu, P Han, J Zhang, Y She, L Yang, J Yu, M Zhuang, K Tang, Y Shi, B Yang, C Liu, B Peng, SJ Ji

Elife (eLife Sciences Publications) China, 18 February 2022

Neuroscience

Organism: Mouse

Tissue: Brain

324
Imaging net retrograde axonal transport in vivo: a physiological biomarker

PTJ Lee, Z Kennedy, Y Wang, Y Lu, C Cefaliello, Ö Uyan, CQ Song, BM da Cruz Godinho, Z Xu, M Rusckowski, W Xue, RH Brown

Annals of Neurology (Wiley) USA, 17 February 2022

Medical Imaging

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

325
Cordycerebroside A inhibits ICAM‐1‐dependent M1 monocyte adhesion to osteoarthritis synovial fibroblasts

KT Lee, CH Su, SC Liu, BC Chen, JW Chang, CH Tsai, WC Huang, CJ Hsu, WC Chen, YC Wu, CH Tang

Journal of Food Biochemistry (Wiley) Taiwan, 15 February 2022

Rheumatology

Key words: Adhesion, Cordycerebroside A, ICAM-1, M1 macrophage, Osteoarthritis

Organism: Human, Rat

Tissue: Joint Tissue

326
Quantitative Characterization of Macrophage, Lymphocyte, and Neutrophil Subtypes Within the Foreign Body Granuloma of Human Mesh Explants by 5-Marker Multiplex Fluorescence Microscopy

U Klinge, A Dievernich, J Stegmaier

Frontiers in Medicine (Frontiers Media S.A.) Germany, 15 February 2022

Medical Image Analysis

Key words: Foreign body granuloma, Mesh, Multiplex, Fluorescence, Macrophage, Lymphocyte, Neutrophil

Organism: Human

Tissue: Surgical mesh

327
A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+ CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy

D Wang, J Fang, S Wen, Q Li, J Wang, L Yang, W Dai, H Lu, J Guo, Z Shan, W Xie, X Liu, L Wen, J Shen, A Wang, Q Chen, Z Wang

International Journal of Oral Science (Nature) China, 14 February 2022

Oncology

Key words: Cancer microenvironment, Head and neck cancer

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

328
Cell-Penetrating Botulinum Neurotoxin Type A With Improved Cellular Uptake and Therapeutic Index

X Wei, L Li, Y Wu, J Liu

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) China, 11 February 2022

Biological Methods, Neuroscience

Key words: Cell-penetrating peptides, Zinc finger proteins, Botulinum neurotoxin type A, Cellular uptake, Therapeutic index

Organism: Mouse

Tissue: Muscle

329
H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice

L Ruilian, Q Honglin, X Jun, L Jianxin, B Qingyun, C Yilin, M Haifeng

Journal of Affective Disorders (Elsevier) China, 10 February 2022

Neuroscience

Key words: Chronic stress stimulated depression model, Hippocampus, Hydrogen sulfide, Inflammatory, Aerobic exercise

Organism: Mouse

Tissue: Brain

Pathological State: Depression

330
The effects of hypoxia on mitochondrial function and metabolism in gastric cancer cells

J Jiang, Y Jiang, YG Zhang, T Zhang, JH Li, DL Huang, J Hou, MY Tian, L Sun, XM Su, Y Dong, YY Ma

Translational Cancer Research (AME Publishing Company) China, 10 February 2022

Oncology

Key words: Gastric cancer, Hypoxia, Mitochondrial function, Aerobic respiration

Organism: Mouse

Pathological State: Cancer

Cell Line: Gastric cancer line MKN45

331
MYC/MAX-Activated LINC00958 Promotes Lung Adenocarcinoma by Oncogenic Transcriptional Reprogramming Through HOXA1 Activation.

T Zhang, F Su, YB Lu, XL Ling, HY Dai, TN Yang, B Zhang, D Zhao, XM Hou

Frontiers in Oncology (Frontiers Media S.A.) China, 09 February 2022

Oncology

Key words: Lung adenocarcinoma, LINC00958, MYC, MAX, Transcriptional reprogramming, HOXA1

Organism: Human

Tissue: Lung

Pathological State: Cancer

332
Colonic Leucine-Rich Repeat Kinase 2 Expression Is Increased and Associated With Disease Severity in Patients With Parkinson's Disease

PH Liao, HL Chiang, CT Shun, JF Hang, HM Chiu, MS Wu, CH Lin

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 08 February 2022

Neuroscience

Key words: Parkinson’s disease, Colon biopsy, Leucine-rich repeat kinase 2, Inflammatory bowel diseases, Biomarker (BM)

Organism: Human

Tissue: Colon

Pathological State: Parkinson's disease

333
Differential localization and limited cytotoxic potential of duodenal CD8+ T cells

L Mvaya, T Khaba, AE Lakudzala, T Nkosi, N Jambo, I Kadwala, A Kankwatira, PD Patel, MA Gordon, TS Nyirenda, KC Jambo, ZM Ndhlovu

JCI Insight (American Society for Clinical Investigation) Malawi, South Africa, UK, USA, 08 February 2022

Immunology

Organism: Human

Tissue: Small Intestine

334
Assessment of Physiological Rat Kidney Ageing—Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation

A Baumgartner, S Reichelt-Wurm, W Gronwald, C Samol, JA Schröder, C Fellner, K Holler, A Steege, FJ Putz, PJ Oefner, B Banas, MC Banas

Metabolites (MDPI) Germany, 08 February 2022

Transplantation Medicine, Nephrology

Key words: Kidney, Ageing, Transplantation, Inflammation, Urinary metabolites

Organism: Rat

Tissue: Kidney

335
ATP8B1 Knockdown Activated the Choline Metabolism Pathway and Induced High-Level Intracellular REDOX Homeostasis in Lung Squamous Cell Carcinoma

X Zhang, R Zhang, P Liu, R Zhang, J Ning, Y Ye, W Yu, J Yu

Cancers (MDPI) China, 07 February 2022

Oncology

Key words: ATP8B1, LUSC, CHKA, REDOX

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

336
Multi-Factorial Nerve Guidance Conduit Engineering Improves Outcomes in Inflammation, Angiogenesis and Large Defect Nerve Repair

AJ Hibbitts, Z Kočí, S Kneafsey, A Matsiko, L Žilić, A Dervan, P Hinton, G Chen, B Cavanagh, JK Dowling, CE McCoy, CT Buckley, SJ Archibald, FJ O'Brien

Matrix Biology (Elsevier) Ireland, USA, 04 February 2022

Neuroscience

Key words: Peripheral Nerve, Biomaterials, Extracellular Matrix, Nerve Guidance Conduit, Angiogenesis, Inflammation

Organism: Rat

Tissue: Nerves

337
Effect of Helicobacter pylori-associated chronic gastritis on autonomous activity and sleep quality in mice

H Liu, W Zheng, L Zhang, T Lin, Y Tang, L Hu

Frontiers in Pharmacology (Frontiers Media S.A.) China, 04 February 2022

Microbiology, Gastroenterology

Key words: Autonomous activity, Chronic gastritis, Helicobacter pylori, Mouse behavior, Sleep quality

Organism: Mouse

Tissue: Stomach

Pathological State: Gastritis

338
Tegaserod Maleate Inhibits Breast Cancer Progression and Enhances the Sensitivity of Immunotherapy

X Li, L Wu, Z Zheng, H Liu, H Li, G Sun, G Sun, Y Cheng, H Wang, Z Li, J Shi, W Tang

Journal of Oncology (Hindawi Publishing Corporation) China, Germany, 03 February 2022

Oncology, Pharmacology

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

339
Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR Publications) USA, 02 February 2022

Oncology, Immunology

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

340
Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues

M Tsuda, R Horio, L Wang, T Takenami, J Moriya, J Suzuka, H Sugino, Z Tanei, M Tanino, S Tanaka

Scientific Reports (Nature) Japan, 02 February 2022

Biological Methods

Key words: Assay systems, Biotechnology

Organism: Human

Tissue: Colon

Pathological State: Cancer

341
Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond

S Chen, W Li, X Zheng, P Yu, P Wang, Z Sun, Y Xu, D Jiao, X Ye, M Cai, M Shen, M Wang, Q Zhang, F Kong, Y Wang, J He, H Wei, F Shi, J Du

PNAS (United States National Academy of Sciences) China, 01 February 2022

Oncology

Key words: Tumor Tissue, Histological Magnetometry, Nitrogen-Vacancy Center, Micrometer-Resolution Magnetic Imaging, Absolute Magnetic Quantification

Organism: Human

Tissue: Lung

Pathological State: Cancer

342
PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through β-catenin dysregulation

BY Ahn, MH Jeong, JH Pyun, HJ Jeong, TA Vuong, JH Bae, S An, SW Kim, YK Kim, D Ryu, HJ Kim, H Cho, GU Bae, JS Kang

Cellular and Molecular Life Sciences (Springer) South Korea, 28 January 2022

Cardiology

Key words: PRMT7, Cardiomyopathy, Wnt, β-catenin

Organism: Rat

Pathological State: Cardiac Fibrosis

Cell Line: Neonatal rat ventricular myocyte (NRVM) cells

343
Regorafenib enhances antitumor immune efficacy of anti-PD-L1 immunotherapy on oral squamous cell carcinoma

IT Chiang, YH Lee, ZL Tan, FT Hsu, HF Tu

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 26 January 2022

Oncology, Pharmacology

Key words: Oral squamous cells carcinoma, Regorafenib, Anti-PD-L1, Antitumor-induced immunity

Organism: Mouse

Tissue: Mucosa

Pathological State: Cancer

344
Metastatic Tumor Antigen 1 Contributes to Hepatocarcinogenesis Posttranscriptionally Through Novel RNA Binding Function

YT Li, CJ Liu, JH Kao, LF Lin, HC Tu, CC Wang, PH Huang, HR Cheng, PJ Chen, DS Chen, HL Wu

Hepatology (Wiley) Taiwan, 24 January 2022

Oncology

Key words: RNA stability, Post-transcriptional control, Tumorigenic capacity, Self-renewal and anchorage-independent growth, Carcinogenesis

Organism: Human

Tissue: Liver

Pathological State: Cancer

345
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach

D Douchi, A Yamamura, J Matsuo, JW Lee, N Nuttonmanit, Y Hui, M Lim, K Suda, M Shimura, S Chen, SC Pang, K Kohu, M Kaneko, H Kiyonari, A Kaneda, H Yoshida, I Taniuchi, M Osato, H Yang, M Unno, JBY So, KG Yeoh, LSH Chuang, SC Bae, Y Ito

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) Singapore, Japan, 21 January 2022

Stem Cell Research, Gastroenterology

Key words: Isthmus, Stem/Progenitor Cell, Enhanced Stem Cell Activity, Preneoplastic State, Gastric Carcinogenesis

Organism: Mouse

Tissue: Stomach

346
Inhibition of β-catenin signaling attenuates arteriovenous fistula thickening in mice by suppressing myofibroblasts

CT Liu, SC Hsu, HL Hsieh, CH Chen, CY Chen, YM Sue, TH Chen, YH Hsu, FY Lin, CM Shih, YT Shiu, PH Huang

Molecular Medicine (BMC) Taiwan, USA, 21 January 2022

Nephrology

Key words: Arteriovenous fistula (AVF), β-catenin, Hemodialysis, Myofibroblast

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney disease

347
Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT

N Kane, T Romero, S Diaz-Perez, MB Rettig, ML Steinberg, AU Kishan, D Schaue, RE Reiter, BS Knudsen, NG Nickols

Prostate Cancer and Prostatic Diseases (Nature) USA, 20 January 2022

Oncology

Key words: Cancer therapy, Prostate cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

348
Chidamide and mitomycin C exert synergistic cytotoxic effects against bladder cancer cells in vitro and suppress tumor growth in a rat bladder cancer model

SC Wang, CY Yu, YC Wu, YC Chang, SL Chen, WW Sung

Cancer Letters (Elsevier) Taiwan, 18 January 2022

Oncology

Key words: Urothelial carcinoma, Histone, N-methyl-N-nitrosourea, Deacetylase, Axl

Organism: Rat

Tissue: Bladder

Pathological State: Cancer

349
Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response

AM Gamage, KS Tan, WOY Chan, ZZR Lew, J Liu, CW Tan, D Rajagopalan, QXX Lin, LM Tan, PN Venkatesh, YW Ong, M Thong, RTP Lin, S Prabhakar, DY Wang, LF Wang

mBio (American Society for Microbiology) Singapore, 18 January 2022

SARS-CoV-2, Immunology

Organism: Human

Pathological State: COVID-19

Cell Line: human nasal epithelial stem/progenitor cells (hNESPCs)

350
Repair phase modeling of ischemic acute kidney injury: recovery vs. transition to chronic kidney disease

K Lee, HR Jang, J Jeon, KE Yang, JE Lee, GY Kwon, DJ Kim, W Huh

American Journal of Translational Research (e-Century Publishing Corporation) South Korea, 15 January 2022

Nephrology

Key words: Ischemic acute kidney injury, Chronic kidney disease, Ischemia-reperfusion injury, Recovery, Repair

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

351
P2RX7 in dopaminergic neurons of ventral periaqueductal gray mediates HTWP acupuncture-induced consciousness in traumatic brain injury

H Tang, S Qin, W Li, X Chen, L Ulloa, Q Zhu, B Liu, Y Gong, Y Zhao, S Wang, S Li, Y Guo, Z Xu, Y Guo

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China, USA, 13 January 2022

Neuroscience

Key words: Acupuncture, Traumatic Brain Injury, Neural Projection, Dopamine, P2RX7, Ventral Periaqueductal Gray, Hand 12 Jing-Well Points

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

352
Cottonseed protein concentrate as fishmeal alternative for largemouth bass (Micropterus salmoides) supplemented a yeast-based paraprobiotic: Effects on growth performance, gut health and microbiome

X Xie, J Wang, Y Guan, S Xing, X Liang, M Xue, J Wang, Y Chang, E Leclercq

Aquaculture (Elsevier) China, France, 13 January 2022

Zoology

Key words: Cottonseed Protein Concentrate, Largemouth Bass, Paraprobiotic, Gut Health, Gut Microbiome

Organism: Bass Fish

Tissue: Small Intestine

Pathological State: Alzheimer's Disease

353
Autochthonous Human Dirofilaria repens Infection in Austria

N Geissler, J Ruff, J Walochnik, W Ludwig, H Auer, U Wiedermann, W Geissler

Acta Parasitologica (Springer) Austria, 12 January 2022

Parasitology

Key words: Dirofilariasis · Nematode infections · Parasitic worms · Climate change · Austria

Organism: D. repens

Tissue: Whole Organism

354
Large deletion of Wdr19 in developing renal tubules disrupts primary ciliogenesis leading to polycystic kidney disease in mice

SS Yu, E Wang, CY Chiang, PH Cheng, YS Yeh, YY Wu, YY Chiou, ST Jiang

The Journal of Pathology (Wiley) Taiwan, 10 January 2022

Nephrology

Key words: Wdr19, intraflagellar transport, primary cilia, renal cyst, polycystic kidney disease

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

355
Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease

HC Campos, DE Ribeiro, D Hashiguchi, DY Hukuda, C Gimenes, SAA Romariz, Q Ye, Y Tang, H Ulrich, B Monteiro Longo

Stem Cell Reviews and Reports (Springer) Brazil, China, 08 January 2022

Neuroscience, Stem Cell Research

Key words: Alzheimer’s Disease, Hippocampus, Neural and Mesenchymal Stem Cell Transplantation, Tissue Cytometry, Amyloid-β plaques

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

356
Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin

W Vankrunkelsven, S Derde, J Gunst, S Vander Perre, E Declerck, L Pauwels, I Derese, G Van den Berghe, L Langouche

Journal of Cachexia, Sarcopenia and Muscle (Wiley) Belgium, 07 January 2022

Infectious Diseases, Endocrinology

Key words: Leptin, Critical Illness, Sepsis, Muscle Weakness, Intensive Care Unit Acquired Weakness, Atrophy, Protein Catabolism

Organism: Mouse

Tissue: Muscle

Pathological State: Sepsis, Obesity

357
Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection

FJ Ogunshola, W Smidt, AF Naidoo, TP Nkosi, T Ngubane, PT Khaba, OO Baiyegunhi, B Mahlobo, S Rasehlo, N Ngema, I Jajbhay, KL Dong, V Ramsuran, J Pansegrouw, T Ndung'u, B Walker, T de Oliveria, ZM Ndhlovu

Blood Advances (ASH Publications) South Africa, USA, Germany, 06 January 2022

Immunology

Key words: Immunobiology, Immunotherapy

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

358
Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity

H Wang, Y Fan, W Chen, Z Lv, S Wu, Y Xuan, Chenfeng Wang, Yongliang Lu,Tao Guo,Donglai Shen,Fan Zhang,Qingbo Huang,Yu Gao,Hongzhao Li,Xin Ma,Baojun Wang,Yan Huang &Xu Zhang

OncoImmunology (Taylor & Francis) China, 05 January 2022

Oncology

Key words: CMTM6, DNA Damage, Cellular Senescence, Immunity, Renal Cell Carcinoma

Organism: Human

Pathological State: Cancer

Cell Line: HKC cells, ccRCC cells, HEK293T cells

359
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages

Z Wang, J Lv, P Yu, Y Qu, Y Zhou, L Zhou, Q Zhu, S Li, J Song, W Deng, R Gao, Y Liu, J Liu, WM Tong, C Qin, B Huang

Cellular & molecular Immunology (Nature) China, 04 January 2022

SARS-CoV-2, Immunology

Key words: SARS-CoV-2, Microparticles, Alveolar Macrophages, Endosomes, Lysosomes

Organism: Mouse

Tissue: Lung

Pathological State: COVID-19

360
Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes

CL Ho, LLH Huang, SJ Shieh

Regenerative Biomaterials (Chinese Society for Biomaterials) Taiwan, 04 January 2022

Stem Cell Research

Key words: Chondrocytes, Cell Proliferation, Perichondrial Progenitor Cells, Paracrine Effect, Neocartilage Formation

Organism: Mouse

Tissue: Joint Tissue

361
Stabilization but no functional influence of HIF-1α expression in the intestinal epithelium during Salmonella Typhimurium infection

L Robrahn, A Dupont, S Jumpertz, K Zhang, CH Holland, J Guillaume, S rappold, J Roth, V Cerovic, J Saez-Rodriguez, MW Hornef, T Cramer

Infection and Immunity (American Society for Microbiology) Germany, The Netherlands, 03 January 2022

Immunology, Microbiology

Organism: Mouse

Tissue: Small Intestine, Large Intestine

Pathological State: Salmonella Typhimurium infection

362
Preclinical Safety of a 3D-Printed Hydroxyapatite-Demineralized Bone Matrix Scaffold for Spinal Fusion

M Plantz, J Lyons, JT Yamaguchi, AC Greene, DJ Ellenbogen, MJ Hallman, V Shah, C Yun, AE Jakus, D Procissi, S Minardi, RN Shah, WK Hsu, EL Hsu

Spine (ingentaconnect) USA, 01 January 2022

Osteology

Key words: 3D Printing, Bone Morphogenetic Protein-2, Demineralized Bone Matrix, Host Inflammatory Response, Hydroxyapatite, Spinal Fusion

Organism: Rat

Tissue: Bone

363
Detection of Cytopathic Effects Induced by Influenza, Parainfluenza, and Enterovirus Using Deep Convolution Neural Network

JJ Chen, PH Lin, YY Lin, KY Pu, CF Wang, SY Lin, TS Chen

Biomedicines (MDPI) Taiwan, 28 December 2021

Machine Learning, Virology

Key words: Artificial Intelligence, Cytopathic Effect, ResNet-50

364
The liquid Kangfuxin (KFX) has efficient antifungal activity and can be used in the treatment of vulvovaginal candidiasis in mouse

J Ma, YC Yang, LQ Su, DM Qin, K Yuan, Y Zhang, RR Wang

Letters in Applied Microbiology (Wiley) China, 27 December 2021

Infectious Diseases, Reproductive Medicine

Key words: Candida Albicans, Kangfuxin Liquid, Antifungal, Vaginal Candidiasis, Murine Model

Organism: Mouse

Tissue: Vagina

Pathological State: Candidiasis

365
Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

CY Chang, KY Chen, HJ Shih, M Chiang, IT Huang, YH Huang, CJ Huang

Pharmaceuticals (MDPI) Taiwan, 27 December 2021

Endocrinology

Key words: Obesity, Sepsis, Liver, Exosomes, let-7i

Organism: Mouse

Tissue: Liver

Pathological State: Obesity

366
Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis

J Zhang, L Wang, C Li, H Zhang, R Li, M Li

Systems biology in Reproductive Medicine (Taylor & Francis) China, 27 December 2021

Reproductive Medicine

Key words: Letrozole, Endometriosis, Endometrial Receptivity, Integrin avβ3, HOXA10

Organism: Rat

Tissue: Endometrium

Pathological State: Endometriosis

367
Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells

K Piatek, A Kutner, D Cacsire Castillo-Tong, T Manhardt, N Kupper, U Nowak, M Chodyński, E Marcinkowska, E Kallay, M Schepelmann

International Journal of Molecular Sciences (MDPI) Austria, Poland, 24 December 2021

Endocrinology, Oncology

Key words: Vitamin D, Vitamin D Analogs, 25 Vitamin D 24-Hydroxylase, CYP24A1, Proliferation, High-Grade Serous Ovarian Cancer Cells

Organism: Human

Pathological State: Cancer

Cell Line: Ovarian cancer cells

368
Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression

YH Chu, WC Liao, YJ Ho, CH Huang, TJ Tseng, CH Liu

Cells (MDPI) Taiwan, 20 December 2021

Oncology

Key words: Glioma, Chondroitin Sulfate, CHSY1, Integrin Β1, CD44, Therapeutic Peptide

369
S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 …

K Tanigawa, S Tsukamoto, Y Koma, Y Kitamura, S Urakami, M Shimizu, M Fujikawa, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki

The American Journal of Pathology (Elsevier) Japan, 20 December 2021

Oncology

Organism: Human

Pathological State: Cancer

Cell Line: Peripheral blood monocytes

370
Spatial point pattern analysis identifies mechanisms shaping the skin parasite landscape in Leishmania donovani infection

JSP Doehl, H Ashwin, N Brown, A Romano, S Carmichael, JW Pitchford, PM Kaye

Frontiers in Immunology (Frontiers Media S.A.) UK, 16 December 2021

Parasitology

Key words: Leishmania donovani, host cell, dispersion, dispersal, skin patches, spatial point pattern analysis

Organism: Mouse

Tissue: Skin

Pathological State: Leishmaniasis

371
P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease

Y Li, H Zhang, J Yang, M Zhan, X Hu, Y Liu, L Yu, X Yan, S Liang, R Zhang, Y Lu, B Li, C Liu, M Li

Chinese Medicine (Springer) China, 16 December 2021

Gastroenterology

Key words: P2Y12 Receptor, Visceral Pain, Depression, EA, IBD

Organism: Mouse

Tissue: Brain

Pathological State: depression, inflammatory bowel disease

372
Hedgehog-signalling in papillary fibroblasts is essential for hair follicle regeneration during wound healing

S Frech, A Forsthuber, A Korosec, K Lipp, V Kozumov, BM Lichtenberger

Journal of Investigative Dermatology (Elsevier) Austria, 16 December 2021

Dermatology

Key words: Wound Healing, Dermal Fibroblast Lineages, Hedgehog Signaling, Hair Follicle Neogenesis, WIHN, Papillary and Reticular Fibroblasts, Regeneration

Organism: Mouse

Tissue: Skin

373
Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma

C Wang, Y Huang, X Ma, B Wang, X Zhang

International Journal of Immunpathology and Pharmacology (SAGE Journals) China, 15 December 2021

Oncology

Key words: Clear Cell Renal Cell Carcinoma, NEK2, Prognosis

Organism: Human

Tissue: Kidney

Pathological State: Cancer

374
CD163+ M2 macrophages promote fibrosis in IgG4‐related disease via TLR7/IRAK4/NF‐κB signaling

A Chinju, M Moriyama, N Kakizoe-Ishiguro, H Chen,Y Miyahara, AR Haque, K Furusho, M Sakamoto, K Kai, K Kibe, S Hatakeyama-Furukawa, M Ito-Ohta, T Maehara, S Nakamura

Arthritis & Rheumatology (Wiley) Japan, Bangladesh, 15 December 2021

Immunology, Rheumatology

Key words: Igg4-Related Disease, M2 Macrophage, Toll-Like Receptor 7, IL-1 Receptor-Associated Kinase 4, Fibrosis

Organism: Human

Tissue: Salivary Gland

Pathological State: IgG4-Related Disease

375
Nuplazid suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting PAK4

Y Wei, W Wu, Y Jiang, H Zhou, Y Yu, L Zhao, X Wu, X Lu, Q Yuan, Z Wang, Z Dong, L He, J Zhao, K Liu

British Journal of Cancer (Nature) China, 15 December 2021

Oncology

Key words: Cancer Prevention

Organism: Mouse

Tissue: Xenograft Tumor, Esophagus

Pathological State: Cancer

376
A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice

K Cao, X Wang, H Peng, L Ding, X Wang, Y Hu, L Dong, T Yang, X Hong, M Xing, D Li, C Zhu, X He, C Zhao, P Zhao, D Zhou, X Zhang, J Xu

Journal of Virology (American Society for Microbiology) China, 15 December 2021

SARS-CoV-2

Key words: COVID-19, Vaccine, SARS-CoV-2 Variants, Influenza, Adenoviral Vector

Organism: Mouse

Tissue: Lung

Pathological State: COVID-19

377
Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development

T Wang, J Zhang, N Li, M Li, S Ma, S Tan, X Guo, Z Wang, Z Wu, L Gao, C Ma, X Liang

Molecular Therapy (Cell Press) China, 15 December 2021

Oncology

Key words: Tim-3, Tim-3 Ligands, Immune Checkpoint Blockade, Tumor Microenvironment, Multiplexed Immunofluorescence

Organism: Human

Tissue: Liver

Pathological State: Cancer

378
Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response

YT Yen, M Chien, PY Wu, CC Ho, CT Ho, KCY Huang, SF Chiang, KSC Chau, WTL Chen, SC Hung

Nature Communications (Nature) Taiwan, 15 December 2021

Oncology, Immunology

Key words: Cancer Immunotherapy, Colon Cancer, Gene Silencing, Immunoediting

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

379
Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

J Chen, J Fan, Z Chen, M Zhang, H Peng, J Liu, L Ding, M Liu, C Zhao, P Zhao, S Zhang, X Zhang, J Xu

PNAS (United States National Academy of Sciences) China, 14 December 2021

SARS-CoV-2

Organism: Human

Pathological State: COVID-19

Cell Line: WT A549 cells

380
Polypharmacological reprogramming of tumor-associated macrophages towards an inflammatory phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR Publications) USA, 13 December 2021

Oncology

Key words: Tumor-Associated Macrophage, Breast Cancer, Tumor Microenvironment, Kinase Inhibitor Screening, Cell-Cell Interaction

Organism: Mouse

Tissue: Allograft Tumor, Lung

Pathological State: Cancer

381
The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model

A Kannan, S Minardi, DJ Ellenbogen, MJ Hallman, AC Greene, JT Yamaguchi, MA Plantz, S Jeong, KC Sana, V Shah, C Yun, EL Hsu, WK Hsu

JOR Spine (Wiley) USA, 13 December 2021

Rheumatology

Key words: Local Steroid, Osteogenesis, Pseudarthrosis, Spine Fusion

Organism: Mouse

Tissue: Bone

Pathological State: Spinal arthrodesis

382
The plasminogen receptor Plg‐RKT regulates adipose function and metabolic homeostasis

F Samad, H Bai, N Baik, P Haider, Y Zhang, G Rega-Kaun, C Kaun, M Prager, J Wojta, Q Bui, S Chakrabarty, J Wang, RJ Parmer, LA Miles

Journal of Thrombosis and Haemostasis (Wiley) USA, Austria, 12 December 2021

Endocrinology

Key words: Adipose Inflammation, Hepatic Steatosis, Insulin Resistance, Obesity, Plg-RKT

Organism: Human

Tissue: Adipose Tissue

Pathological State: Obesity

383
Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension

Z Zhao, Z Guo, Z Yin, Y Qiu, B Zhou

Frontiers in Physiology (Frontiers Media S.A.) China, 10 December 2021

Gastroenterology

Key words: Intra-Abdominal Hypertension, Abdominal Compartment Syndrome, Fecal Microbiota Transplantation, 16S rRNA, Gut Microbiota Dysbiosis

Organism: Rat

Tissue: Liver

Pathological State: Liver Injury

384
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

T Zhang, L Sun, Y Hao, C Suo, S Shen, H Wei, W Ma, P Zhang, T Wang, X Gu, ST Li, Z Chen, R Yan, Y Zhang, Y Cai, R Zhou, W Jia, F Huang, P Gao, H Zhang

Nature Cancer (Nature) China, 09 December 2021

Oncology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

385
FGL1 as a Novel Mediator and Biomarker of Malignant Progression in Clear Cell Renal Cell Carcinoma.

Z Lv, B Cui, X Huang, HY Feng, T Wang, HF Wang, YD Xuan, HZ Li, X Ma, Y Huang, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 09 December 2021

Oncology

Key words: biomarker, clear cell renal cell carcinoma, epithelial to mesenchymal transition, fibrinogen-like protein 1, progression

Organism: Human

Tissue: Kidney

Pathological State: Cancer

386
CD146 as a Prognostic-Related Biomarker in ccRCC Correlating With Immune Infiltrates

Z Lv, HY Feng, W Tao, HZ Li, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 08 December 2021

Oncology

Key words: CD146, ccRCC, prognosis, methylation, tumor microenvironment

Organism: Human

Tissue: Kidney

Pathological State: Cancer

387
Lipid Droplet-Specific Probe for Rapidly Locating Atherosclerotic Plaques and Intraoperative Imaging via In Situ Spraying

M Sang, B Cai, S Qin, S Zhao, Y Mao, Y Wang, X Yu, J Zheng

ACS Applied Materials & Interfaces (ACS Publications) China, 06 December 2021

Biological Methods

Key words: Lipids, Liquids, Fluorescence, Fluorescence Imaging, Probes

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

388
Hedgehog signaling controls bone homeostasis by regulating osteogenic/adipogenic fate of skeletal stem/progenitor cells in mice

L Zhang, X Fu, L Ni, C Liu, Y Zheng, H You, M Li, C Xiu, L Zhang, T Gong, N Luo, Z Zhang, G He, S Hu, H Yang, D Chen, J Chen

Journal of Bone and Mineral Research (Wiley) China, 06 December 2021

Osteology, Stem Cell Research

Key words: Genetic Animal Models, Hedgehogs, Stromal/Stem Cells, Osteoporosis, Aging

Organism: Mouse

Tissue: Bone

389
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

JL Zhang, YH Li, LL Wang, HQ Liu, SY Lu, Y Liu, K Li, B Liu, SY Li, FM Shao, K Wang, N Sheng, R Li, JJ Cui, PC Sun, CX Ma, B Zhu, Z Wang, YH Wan, SS Yu, Y Che, CY Wang, C Wang, Q Zhang, LM Zhao, XZ Peng, Z Cheng, JB Chang, JD Jiang

Signal Transduction and Targeted Therapy (Nature) China, 06 December 2021

SARS-CoV-2

Key words: Drug Development, Infectious Diseases

Organism: Monkey

Tissue: Brain, Lung

Pathological State: COVID-19

390
Ascorbic acid-2 glucoside mitigates intestinal damage during pelvic radiotherapy in a rat bladder tumor model

Y Ito, T Yamamoto, K Miyai, J Take, H Scherthan, A Rommel, S Eder, K Steinestel, A Rump, M Port, N Shinomiya, M Kinoshita

International Journal of Radiation Biology (Taylor & Francis) Japan, Germany, 06 December 2021

Oncology, Radiotherapy

Key words: AY-27 Cells, DNA Damage, 53BP1, CD163, M1/M2, Macrophages

Organism: Rat

Tissue: Bladder

Pathological State: Cancer

391
Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration

M Zou, L Gong, Q Ke, R Qi, X Zhu, W Liu, Q Sun, X Tang, Z Luo, X Gong, Y Liu, DWC Li

Free Radical Biology and Medicine (Elsevier) China, 04 December 2021

Cell Biology

Key words: Age-Related Macular Degeneration, Heterochromatin, Inflammation, Methotrexate, cGAS, STING

Organism: Mouse

Tissue: Eye

Pathological State: Macular degeneration

392
Defect of LSS Disrupts Lens Development in Cataractogenesis.

M Zhao, T Mei, B Shang, B Zou, Q Lian, W Xu, K Wu, Y Lai, C Liu, L Wei, J Zhu, K Zhang, Y Liu, L Zhao

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 02 December 2021

Developmental Biology

Key words: lanosterol synthase, congenital cataract, mouse model, mutation, lens development

Organism: Mouse

Tissue: Eye

Pathological State: Cataract

393
Mad2 Induced Aneuploidy Contributes to Eml4-Alk Driven Lung Cancer by Generating an Immunosuppressive Environment

K Alikhanyan, Y Chen, K Somogyi, S Kraut, R Sotillo

Cancers (MDPI) Germany, 30 November 2021

Oncology

Key words: Lung Cancer, Aneuploidy, Tumor Microenvironment, Immune Suppression, Mouse Models

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

394
Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1

A Lo, K Holmes, S Kamlapurkar, F Mundt, S Moorthi, I Fung, S Fereshetian, J Watson, SA Carr, P Mertins, AH Berger

Science Signaling (Science) USA, 30 November 2021

Oncology

Organism: Human

Cell Line: AALE cells

395
Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy

A Dodd, AA Natfji, A Evangelinos, A Grigoletto, G Pasut, F Beards, L Renshall, HMI Osborn, F Greco, LK Harris

Molecular Pharmaceutics (ACS Publications) UK, Italy, 29 November 2021

Pharmacology

Key words: Polymer−Drug Conjugate PEG Pregnancy Placenta Transport Drug Delivery

Organism: Human

Tissue: Placenta

Pathological State: Pregnancy

396
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

VA Arrieta, AX Chen, JR Kane, SJ Kang, C Kassab, C Dmello, J Zhao, KB Burdett, PS Upadhyayula, C Lee-Chang, J Shilati, D Jaishankar, L Chen, A Gould, D Zhang, J Yuan, W Zhao, X Ling, JK Burks, B Laffleur, C Amidei, JN Bruce, RV Lukas, JT Yamaguchi, D Cieremans, G Rothschild, U Basu, M McCord, DJ Brat, H Zhang, LAD Cooper, B Zhang, P Sims, TF Cloughesy, R Prins, P Canoll, R Stupp, AB Heimberger, C Horbinski, FM Iwamoto, R Rabadan, AM Sonabend

Nature Cancer (Nature) USA, Mexico, France, 29 November 2021

Oncology

Key words: Cancer, Cancer Immunotherapy, CNS Cancer, Tumour Biomarkers

Organism: Human

Tissue: Brain

Pathological State: Cancer

397
Single cell imaging-based chromatin biomarkers for tumor progression

S Venkatachalapathy, DS Jokhun, M Andhari, GV Shivashankar

Scientific Reports (Nature) Singapore, India, Italy, Switzerland, 29 November 2021

Oncology

Key words: Biomarkers, Biophysics, Cancer, Computational Biology and Bioinformatics

Organism: Human

Tissue: Breast

Pathological State: Cancer

398
Lipid‐Activatable Fluorescent Probe for Intraoperative Imaging of Atherosclerotic Plaque Using In Situ Patch

J Zheng, S Zhao, Y Mao, Z Du, G Li, M Sang

Nano Micro Small (Wiley) China, 27 November 2021

Biological Methods

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

399
HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

C Da, J Pu, Z Liu, J Wei, Y Qu, Y Wu, B Shi, J Yang, N He, P Hou

Signal Transduction and Targeted Therapy (Nature) China, 24 November 2021

Oncology

Key words: Cancer, Molecular Biology

Organism: Human

Tissue: Brain

Pathological State: Cancer

400
Mechanism of Chronic Stress-Induced Glutamatergic Neuronal Damage in the Basolateral Amygdaloid Nucleus

S Wang, X Liu, W Shi, Q Qi, G Zhang, Y Li, B Cong, M Zuo

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 23 November 2021

Neuroscience

Organism: Rat

Tissue: Brain

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