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Customer Publications (A total of 2116 papers published)

201
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

VA Arrieta, AX Chen, JR Kane, SJ Kang, C Kassab, C Dmello, J Zhao, KB Burdett, PS Upadhyayula, C Lee-Chang, J Shilati, D Jaishankar, L Chen, A Gould, D Zhang, J Yuan, W Zhao, X Ling, JK Burks, B Laffleur, C Amidei, JN Bruce, RV Lukas, JT Yamaguchi, D Cieremans, G Rothschild, U Basu, M McCord, DJ Brat, H Zhang, LAD Cooper, B Zhang, P Sims, TF Cloughesy, R Prins, P Canoll, R Stupp, AB Heimberger, C Horbinski, FM Iwamoto, R Rabadan, AM Sonabend

Nature Cancer (Nature) USA, Mexico, France, 29 November 2021

Oncology

Key words: Cancer, Cancer Immunotherapy, CNS Cancer, Tumour Biomarkers

Organism: Human

Tissue: Brain

Pathological State: Cancer

202
Single cell imaging-based chromatin biomarkers for tumor progression

S Venkatachalapathy, DS Jokhun, M Andhari, GV Shivashankar

Scientific Reports (Nature) Singapore, India, Italy, Switzerland, 29 November 2021

Oncology

Key words: Biomarkers, Biophysics, Cancer, Computational Biology and Bioinformatics

Organism: Human

Tissue: Breast

Pathological State: Cancer

203
Lipid‐Activatable Fluorescent Probe for Intraoperative Imaging of Atherosclerotic Plaque Using In Situ Patch

J Zheng, S Zhao, Y Mao, Z Du, G Li, M Sang

Nano Micro Small (Wiley) China, 27 November 2021

Biological Methods

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

204
HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

C Da, J Pu, Z Liu, J Wei, Y Qu, Y Wu, B Shi, J Yang, N He, P Hou

Signal Transduction and Targeted Therapy (Nature) China, 24 November 2021

Oncology

Key words: Cancer, Molecular Biology

Organism: Human

Tissue: Brain

Pathological State: Cancer

205
Mechanism of Chronic Stress-Induced Glutamatergic Neuronal Damage in the Basolateral Amygdaloid Nucleus

S Wang, X Liu, W Shi, Q Qi, G Zhang, Y Li, B Cong, M Zuo

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 23 November 2021

Neuroscience

Organism: Rat

Tissue: Brain

206
Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

C Wang, A Cui, M Bukenya, A Aung, D Pradhan, CA Whittaker, Y Agarwal, A Thomas, S Liang, P Amlashi, H Suh, S Spranger, N Hacohen, DJ Irvine

Cell Reports (Cell Press) USA, 23 November 2021

Immunology, Oncology

Key words: NK Cell, Macrophage, Checkpoint Blockade, Sensitization, Tumor-Targeting Antibody, Interleukin-2, Tumor Microenvironment, Vascular Normalization

Organism: Mouse

Tissue: Allograft Tumor, Skin

Pathological State: Cancer

207
Pectins from various sources inhibit galectin-3-related cardiac fibrosis

AR van der Velde, WC Meijers, HHW Silljé, P Muntendam, MM Dokter, WH van Gilst, HA Schols, RA de Boer

Current Research in Translational Medicine (Elsevier) USA, The Netherlands, 23 November 2021

Cardiology

Key words: Galectin-3, Inhibitor, Pectin, Heart failure, Fibrosis, Affinity

Organism: Human

Cell Line: Monocytes

208
Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds

WH Tsai, CH Chou, TY Huang, HL Wang, PJ Chien, WW Chang, HT Lee

Cells (MDPI) Taiwan, 22 November 2021

Dermatology

Key words: Heat-Killed Probiotics, Lactobacillus, L. Plantarum, L. Paracasei, Skin Wound Healing, Lipoteichoic Acid

Organism: Mouse

Tissue: Skin

Pathological State: Cutaneous Wound

209
Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin-and mucosa-resident memory T cells

S Saluzzo, RV Pandey, LM Gail, R Dingelmaier-Hovorka, L Kleissl, L Shaw, B Reininger, D Atzmüller, J Strobl, V Tonzeau-Römer, A Beer, C Staud, A Rieger, M Farlik, W Weninger, G Stingl, G Stary

Immunity (Cell Press) Austria, 22 November 2021

Immunology, Virology

Key words: HIV, Tissue-Resident Memory T Cells, Skin, Mucosal Immunity, HPV, Cancer, CXCR3

Organism: Human

Tissue: Skin

Pathological State: HIV Infection

210
CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c. 1085 Genotypes

YM Yeh, PC Lin, WC Su, MR Shen

International Journal of Molecular Sciences (MDPI) Taiwan, 22 November 2021

Oncology

Key words: Colony-Stimulating Factor 1 Receptor, Genetic Variant, CD40, IL-2 Expression, Colorectal Cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

211
BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression

Q Wu, F Liu, M Ge, KV Laster, L Wei, R Du, M Jiang, J Zhang, Y Zhi, G Jin, S Zhao, DJ Kim, Z Dong, K Liu

Oncogene (Nature) China, 19 November 2021

Oncology

Key words: Oncogenes, Transcription

Organism: Human

Cell Line: KYSE450 cells

212
Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca2+ …

R Wang, M Wang, B Liu, H Xu, J Ye, X Sun, G Sun

Biomedicine & Pharmacotherapy (Elsevier) China, 17 November 2021

Cardiology

Key words: calenduloside E, myocardial ischemia-reperfusion injury, L-type Ca2+ channels, BAG3, calcium overload, autophagy

Organism: Rat

Tissue: Heart

Pathological State: Myocardial ischemia

213
Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy

M Gao, Y Chen, C Wu

Bioengineered (Taylor & Francis) China, 16 November 2021

Nanomedicine, Oncology

Key words: Malignant Glioma, Doxorubicin-Loaded Nanoparticles, Chemosensitization, Tumor Chemotherapy, Size-Dependent

Organism: Mouse

Tissue: Heart, Kidney, Liver, Lung, Spleen

Pathological State: Cancer

214
Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells

KC Wei, YC Lin, CH Chen, YH Chu, CY Huang, WC Liao, CH Liu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, 15 November 2021

Oncology

Key words: Fucosyltransferase 8, Glioma, HGF, MET, EGFR

Organism: Human

Tissue: Brain

Pathological State: Cancer

215
HSBP1 Is a Novel Interactor of FIP200 and ATG13 That Promotes Autophagy Initiation and Picornavirus Replication

M Mauthe, N Dinesh Kumar, P Verlhac, N van de Beek, F Reggiori

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) The Netherlands, 15 November 2021

Virology

Key words: Autophagy, Infection, ULK Kinase Complex, EMCV, CVB3, EV71

Organism: Human

Cell Line: U2OS cells 

216
Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

LC Wang, WY Wei, PC Ho, PY Wu, YP Chu, KJ Tsai

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 12 November 2021

Neuroscience

Key words: Cortical Electrical Stimulation, Neuromodulation, Ischemic Stroke, BDNF, PI3K – PKB/Akt Signaling Pathway

Organism: Rat

Tissue: Brain

Pathological State: Stroke

217
TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma

EY Lee, M Kim, BK Choi, DH Kim, I Choi, HJ You

Molecules and Cells (Korean Society for Molecular and Cellular Biology) South Korea, 12 November 2021

Oncology

Key words: cytokines, leiomyosarcoma, tjp1, tumor microenvironment

Organism: Mouse

Tissue: Xenograft Tumor, Esophagus

Pathological State: Cancer

218
Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

AE Hinman, C Jani, SC Pringle, WR Zhang, N Jain, AJ Martinot, AK Barczak

eLife (eLife Sciences Publications) USA, 10 November 2021

Immunology, Microbiology

Organism: Mouse

Tissue: Lung

Pathological State: Tuberculosis

219
Dopamine D2 receptor regulates cortical synaptic pruning in rodents

YQ Zhang, WP Lin, LP Huang, B Zhao, CC Zhang, DM Yin

Nature Communications (Nature) China, 08 November 2021

Neuroscience

Key words: Diseases of The Nervous System, Molecular Neuroscience, Spine Regulation and Structure, Synaptic Development

Organism: Rat

Tissue: Brain

220
Donor Bone Marrow Derived Macrophage Engraftment into the Central Nervous System of Allogeneic Transplant Patients

AM Loeb, SS Pattwell, A Bedalov, S Meshinchi, KR Loeb

Blood (ASH Publications) USA, 05 November 2021

Hematology

Organism: Human

Tissue: Bone Marrow

Pathological State: Allogeneic Transplantation

221
IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1

WJ Wu, SH Wang, CC Wu, YA Su, CY Chiang, CH Lai, TH Wang, TL Cheng, JY Kuo, TC Hsu, TH Lin, YJ Lee

International Journal of Molecular Sciences (MDPI) Taiwan, 05 November 2021

Reproductive Medicine

Key words: IL-4, IL-13, Mammary Glands, Cell Proliferation, STAT6, IRS Protein

Organism: Human

Cell Line: Mammary epithelial cells

222
Cholesterol-lowering Intervention Decreases mTOR Complex 2 Signaling and Enhanced Antitumor Immunity

Y Wang, S You, S Su, A Yeon, E Lo, S Kim, J Mohler, MR Freeman, HL Kim

Clinical Cancer Research (AACR) USA, 02 November 2021

Oncology

Organism: Human

Tissue: Prostate

Pathological State: Cancer

223
Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

RJ Ni, YM Shu, T Li, JN Zhou

Frontiers in Neuroanatomy (Frontiers Media S.A.) China, 02 November 2021

Neuroscience

Key words: Caudate Nucleus, Putamen, Accumbens Nucleus, Thalamus, Neural Circuits

Organism: Tree Shrew

Tissue: Brain

224
Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals

S Fischer, E Nasyrov, M Brosien, KT Preissner, HM Marti, R Kunze

Journal of Neuroinflammation (BMC) Germany, 02 November 2021

Neuroscience

Key words: Extracellular RNA, Astrocyte, Inflammation, Stroke, Ischemia/Reperfusion, PAMP, DAMP, TLR

Organism: Mouse

Tissue: Brain

225
Expression of Vascular Cell Adhesion Molecule-1 in Peripheral Artery Disease is Enriched in Patients with Advanced Kidney Disease

PT Lee, IC Liao, CH Lee, LW Hsu, PY Liu

Acta Cardiologica Sinica (Taiwan Society of Cardiology) Taiwan, 01 November 2021

Cardiology

Key words: Chronic Kidney Disease, Hemodialysis

Organism: Human

Tissue: Kidney

Pathological State: Vascular Disease, Kidney Disease

226
SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway

CY Kuo, YC Chang, MN Chien,

Endocrine-Related Cancer (Society for Endocrinology) Taiwan, 01 November 2021

Oncology

Key words: SREBP1, Invasion, Thyroid Cancer, Lipid Metabolism

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

227
SPION NANOPARTICLES IN VITRO AND IN VIVOTESTING FOR ANTIMELANOMA DRUG RELEASE INTO TUMORS

M Doni, HF Oancea, HRC Fierăscu

The International Symposium PRIOrities of CHEMistry for a sustainable development (ICECHIM) Romania, 29 October 2021

Oncology, Nanomedicine

Key words: melanoma cells, syngeneic melanoma mouse model, drug delivery, IHC, RT-qPCR

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

228
Spatiotemporal Protein Expression Profiles of QSOX1 in the Murine Uterus, Placenta, and Embryo during Pregnancy

HS Lin, RKK Lee, TH Yang, HW Fang, SH Li

Applied Sciences (MDPI) Taiwan, 29 October 2021

Reproductive Medicine

Key words: Quiescin Sulfhydryl Oxidase 1, Uterus, Placenta, Embryo, Maternal-Fetal Interface, Tissue Distribution, Pregnancy

Organism: Mouse

Tissue: Uterus, Placenta, Embryo

Pathological State: Pregnancy

229
Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer

BL Horton, DM Morgan, N Momin, M Zagorulya, E Torres-Mejia, V Bhandarkar, KD Wittrup, JC Love, S Spranger

Science Immunology (Science) USA, 29 October 2021

Oncology, Immunology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

230
Carboxypeptidase N1 is anticipated to be a synergy metrics for chemotherapy effectiveness and prognostic significance in invasive breast cancer

YY Fan, CH Liu, AL Wu, HC Chen, YJ Hsueh, KJ Chen, CC Lai, CY Huang, WC Wu

Cancer Cell International (Springer) China, 28 October 2021

Oncology

Key words: Carboxypeptidase N1, CA153, Chemotherapeutic Efficacy, Prognosis, Invasive Breast Cancer

Organism: Human

Tissue: Breast

Pathological State: Cancer

231
Increased osteogenic activity of dynamic cultured composite bone scaffolds: Characterization and in vitro study

ML Mueller, MP Ottensmeyer, JR Thamm, R Schmelzeisen, MJ Troulis, FPS Guastaldi

Journal of Oral and Maxillofacial Surgery (Elsevier) USA, Germany, 27 October 2021

Osteology

Key words: Scaffolds, Bone Tissue Engineering, Calcium Phosphate, 3D Printing, ALP

Organism: Human

Cell Line: pBMSCs

232
Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer

PF Yueh, YH Lee, I Chiang, WT Chen, KL Lan, CH Chen, FT Hsu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, USA, 26 October 2021

Oncology

Key words: Imipramine, Non-Small Cell Lung Cancer (NSCLC), EGFR - Epidermal Growth Factor Receptor, PKC-δ-Protein Kinase C Delta, NF-κB – Nuclear Factor Kappa B

Organism: Mouse

Tissue: Xenograft Tumor, Lung, Liver

Pathological State: Cancer

233
The prognostic value of TCF1+ CD8+ T in primary small cell carcinoma of the esophagus

L Ma, L Sun, K Zhao, Z Dong, Z Huang, X Meng

Cancer Science (Japanese Cancer Association) China, 25 October 2021

Oncology

Key words: prognosis, PSCCE, stem‐like, TCF1, tumor microenvironment

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

234
Metabolic memory underlying minimal residual disease in breast cancer

K Radic Shechter, E Kafkia, K Zirngibl, S Gawrzak, A Alladin, D Machado, C Lüchtenborg, DC Sevin, B Brügger, KR Patil, M Jechlinger

Molecular Systems Biology (EMBO press) Germany, UK, 25 October 2021

Oncology

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

235
Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction

LJ Renshall, F Beards, A Evangelinos, SL Greenwood, P Brownbill, A Stevens, CP Sibley, JD Aplin, ED Johnstone, T Teesalu, LK Harris

Pharmaceutics (MDPI) UK, USA, 25 October 2021

Reproductive Medicine

Key words: Placenta, Pregnancy, Fetal Growth Restriction, LLiposomes, Epidermal Growth Factor

Organism: Human

Tissue: Placenta

236
Cardiac Fibrosis Is a Risk Factor for Severe COVID-19

J Mustroph, J Hupf, MJ Baier, K Evert, C Brochhausen, K Broeker, C Meindl, B Seither, C Jungbauer, M Evert, LS Maier, S Wagner

Frontiers in Immunology (Frontiers Media S.A.) Germany, 22 October 2021

SARS-CoV-2

Key words: SARS-CoV-2, COVID-19, Fibrosis, Heart, TGF-β1, NRP-1

Organism: Human

Tissue: Heart

Pathological State: COVID-19

237
Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist

H Mei, Z Zha, W Wang, Y Xie, Y Huang, W Li, D Wei, X Zhang, J Qu, J Liu

Genome Biology (BMC) China, 22 October 2021

Genetics

Key words: CRISPR, Genome-wide screen, Surfaceome screen, Rhinovirus, OLFML3

Organism: Human

Pathological State: Rhinovirus Infection

Cell Line: HeLa cells

238
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

C Shen, R Li, R Negro, J Cheng, SM Vora, TM Fu, A Wang, K He, L Andreeva, P Gao, Z Tian, RA Flavell, S Zhu, H Wu

CELL (Cell Press) USA, China, Italy, 21 October 2021

Immunology, Virology

Key words: NLRP6, dsRNA, Liquid-Liquid Phase Separation, LLPS, Inflammasome, MHV, RV, IDRs

Organism: Mouse

Tissue: Liver

239
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

C Vinel, G Rosser, L Guglielmi, M Constantinou, N Pomella, X Zhang, JR Boot, TA Jones, TO Millner, AA Dumas, V Rakyan, J Rees, JL Thompson, J Vuononvirta, S Nadkarni, TE Assan, N Aley, YY Lin, P Liu, S Nelander, D Sheer, CLR Merry F Marelli-Berg, S Brandner, S Marino

Nature Communications (Nature) UK, Hong Kong, Sweden, 21 October 2021

Oncology

Key words: CNS Cancer, Reprogramming

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

240
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements

SM Zhang, WL Cai, X Liu, D Thakral, J Luo, LH Chan, MK McGeary, E Song, KRM Blenman, G Micevic, S Jessel, Y Zhang, M Yin, CJ Booth, LB Jilaveanu, W Damsky, M Sznol, HM Kluger, A Iwasaki, MW Bosenberg, Q Yan

Nature (Nature) USA, China, 20 October 2021

Oncology

Key words: Epigenetics, Melanoma

Organism: Mouse

Tissue: Allograft Tumor, Skin

Pathological State: Cancer

241
A Recurrent STAT5BN642H Driver Mutation in Feline Alimentary T Cell Lymphoma

M Kieslinger, A Swoboda, N Kramer, P Freund, B Pratscher, HA Neubauer, R Steinborn, B Wolfesberer, A Fuchs-Baumgartinger, R Moriggl, IA Burener

Cancers (MDPI) Austria, 19 October 2021

Oncology

Key words: STAT5B, driver mutation, feline alimentary lymphoma, STAT3

Organism: Cat

Tissue: Lymphoid Tissue

Pathological State: Cancer

242
Hippocampal and thalamic afferents form distinct synaptic microcircuits in the mouse infralimbic frontal cortex

K Graham, N Spruston, EB Bloss

Cell Reports (Cell Press) USA, 19 October 2021

Neuroscience

Key words: Frontal Cortex, circuit, Synapse, Interneuron, Projection neuron, rabies tracing, hippocampus, thalamus

Organism: Mouse

Tissue: Brain

243
Autophagy Upregulates miR-449a Expression to Suppress Progression of Colorectal Cancer

SH Lan, SC Lin, WC Wang, YC Yang, JC Lee, PW Lin, ML Chu, KY Lan, R Zuchini, HS Liu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, 19 October 2021

Oncology

Key words: autophagy, miR-449a, FoxO1, colorectal cancer, tumorigenesis

Organism: Human

Tissue: Colon

Pathological State: Cancer

244
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis

F Klemm, A Möckl, A Salamero-Boix, T Alekseeva, A Schäffer, M Schulz, K Niesel, RR Maas, M Groth, BT Elie, RL Bowman, ME Hegi, RT Daniel, PS Zeiner, J Zinke, PN Harter, KH Plate, JA Joyce, L Sevenich

Nature Cancer (Nature) Switzerland, Germany, USA, 18 October 2021

Oncology

Key words: Cancer, Cancer microenvironment, Cancer therapeutic resistance, Metastasis

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

245
Recent progress in cytometric technologies and their applications in ecotoxicology and environmental risk assessment

D Wlodkowic, A Czerw, B Karakiewicz, A Deptala

Cytometry Part A (Wiley) Australia, Poland, 15 October 2021

Toxicology

246
An Integrated Bile Acids Profile Determination by UHPLC-MS/MS to Identify the Effect of Bile Acids Supplement in High Plant Protein Diet on Common Carp (Cyprinus carpio)

X Wei, T Yao, FN Fall, M Xue, X Liang, J Wang, W Du, X Gu

Foods (MDPI) China, 15 October 2021

Gastroenterology

Key words: Bile Acids, Common Carp, High Plant Protein Diet, Hepatopancreas, Glycogen Accumulation, UHPLC-MS/MS

Organism: Common Carp

Tissue: Hepatopancreas

247
LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure

CT Su, TM Jao, Z Urban, YJ Huang, DHW See, YC Tsai, WC Lin, JW Huang

Cell Death & Disease (Nature) Taiwan, 13 October 2021

Nephrology

Key words: Cell signalling, Pathogenesis

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Fibrosis

248
Siglec-15 Is an Immune Suppressor and Potential Target for Immunotherapy in the Pre-Metastatic Lymph Node of Colorectal Cancer

H Du, J Tang, X Li, X Wang, L Wu, R Zhang, P Hu, Y Yang

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 13 October 2021

Oncology

Key words: Pre-Metastatic Niche, Lymph Nodes, Colorectal Cancer, Immunosuppressive, SIGLEC15

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

249
Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation

J Strobl, LM Gail, L Kleissl, RV Pandey, V Smejkal, J Huber, V Puxkandl, L Unterluggauer, R Dindelmaier-Hovorka, D Atzmüller, T Krausgruber, C Bock, P Wohlfarth, W Rabitsch, G Stary

Journal of Experimental Medicine (Rockefeller University Press) Austria, 13 October 2021

Immunology

Organism: Human

Cell Line: Keratinocytes

250
Sexual dimorphism in the bed nucleus of the stria terminalis, medial preoptic area and suprachiasmatic nucleus in male and female tree shrews

RJ Ni, YM Shu, PH Luo, JN Zhou

Journal of Anatomy (Wiley) China, 12 October 2021

Reproductive Medicine

Organism: Tree Shrew

Tissue: Brain

251
Changes in expressions of spermatogenic marker genes and spermatogenic cell population caused by stress

P Tian, Z Zhao, Y Fan, N Cui, B Shi, G Hao

Frontiers in Endocrinology (Frontiers Media S.A.) China, 11 October 2021

Reproductive Medicine

Key words: Stress, Testis, Spermatogenesis, Gene, RNA Sequencing

Organism: Rat

Tissue: Testis

252
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

B Wang, L Wang, NS Gasek, Y Zhou, T Kim, C Guo, ER Jellison, L Haynes, S Yadav, T Tchkonia, GA Kuchei, JL Kirkland, M Xu

Nature Aging (Nature) USA, China, 07 October 2021

Aging

Key words: Ageing, Animal biotechnology, Senescence

253
Glucose/Glutathione Co-triggered Tumor Hypoxia Relief and Chemodynamic Therapy to Enhance Photothermal Therapy in Bladder Cancer

WH Chen, KJ Yu, JW Jhou, HH Pang, WH Wenig, WS Lin, HW Yang

ACS Applied Bio Materials (ACS Publications) Taiwan, 07 October 2021

Oncology, Pharmacology

Key words: Photothermal Therapy, Chemodynamic Therapy, Manganese Dioxide (MnO2), Tumor Hypoxia, Bladder Cancer

Organism: Mouse

Tissue: Bladder

Pathological State: Cancer

254
Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs

L Johnson Chacko, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudas, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fischer, A Zine

International Journal of Molecular Sciences (MDPI) USA, France, UK, Canada, 07 October 2021

Genetics

Key words: Human Induced Pluripotent Stem Cells, Otic Sensory Progenitors, Gene Expression Analysis, Extracellular Matrix, Integrins, Human Fetal Inner Ear

Organism: Human

Tissue: Bone

255
Irreversible depletion of intestinal CD4+ T-cells is associated with T-cell activation during chronic HIV infection

OE Asowata, A Singh, A Ngoepe, N Herbert, R Faradoos, K Reddy, Y Zuingu, F Nene, N Mthabela, D Ramjit, K Govender, T Ndung'u, JZ Porterfield, JH Adamson, FG Madela, VT Manzini, F Anderson, A Leslie, HN Kløverpris

JCI Insight (American Society of Clinical Investigation) South Africa, Denmark, UK, Germany, USA, 07 October 2021

Immunology, Virology

Organism: Human

Tissue: Small Intestine

Pathological State: HIV Infection

256
Characterizing the host response to rhPDGF‐BB in a rat spinal arthrodesis model

JT Yamaguchi, JA Weiner, S Minardi, AC Greene, DJ Ellenbogen, MJ Hallman, VP Shah, KM Weisz, S Jeong, T Nandurkar, C Yun, WK Hsu, EL Hsu

JOR Spine (Wiley) USA, 07 October 2021

Osteology

Organism: Mouse

Tissue: Bone

257
Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

H He, Q Liao, C Zhao, C Zhu, M Feng, Z Liu, L Jiang, L Zhang, X Ding, M Yuan, X Zhang, J Xu

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 06 October 2021

Oncology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

258
Landscape of prognostic signatures and immunogenomics of the AXL/GAS6 axis in renal cell carcinoma

K Hakozaki, N Tanaka, K Takamatsu, R Takashi, Y Yasumizu, S Mikami, T Shinojima, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, R Mizuno, M Oya

British Journal of Cancer (Nature) Japan, 05 October 2021

Oncology

Key words: Renal Cell Carcinoma, Tumour Biomarkers

Organism: Human

Tissue: Kidney

Pathological State: Cancer

259
NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression

J Liang, W Sun, H Song, C Wang, Q Li, C Li, D Wie, Y Zhao, C Li, H Zhang

Epigenomics (Future Medicine) China, 05 October 2021

Oncology, Pharmacology

Key words: Epithelial–Mesenchymal Transition, NOL6, Nucleolar Protein, Tumorigenesis, TWIST1

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

260
Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis

NS Dey, S Senaratne, V Somaratne, NP Madarasinghe, B Seneviratne, S Forrester, M Montes de Oca, L Capos Reis, S Moulik, PB Walrad, M Chatterjee, H Goto, R Wickremasinghe, D Lagos, PM Kaye, S Ranasinghe

The Journal of Clinical Investigation (American Society of Clinical Investigation) UK, Sri Lanka, Brazil, India, 05 October 2021

Immunology, Parasitology

Key words: Immunology, Infectious Disease

Organism: Human

Tissue: Skin

Pathological State: Leishmaniasis, Dermal lesions

261
Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model

MK Chiang, PY Hsiao, YY Liu, HL Tang, CS Chiou, MC Lu, YC Lai

Gut Microbes (Taylor & Francis) Taiwan, 04 October 2021

Oncology, Microbiology

Key words: Klebsiella Pneumoniae, ST11, Colorectal Tumorigenesis, IL-10, M2 Macrophages

Organism: Mouse

Tissue: Colon

Pathological State: Klebsiella Infection, Cancer

262
Epstein-Barr Virus Promotes Tumor Angiogenesis by Activating STIM1-Dependent Ca2+ Signaling in Nasopharyngeal Carcinoma

J Ye, J Wei, Y Luo, Y Deng, T Que, X Zhang, F Liu, J Zhang, X Luo

Pathogens (MDPI) China, 03 October 2021

Oncology, Virology

Key words: Epstein-Barr Virus, Stromal Interaction Molecule 1, Tumor Angiogenesis, Nasopharyngeal Carcinoma

Organism: Human

Tissue: Nasopharynx

Pathological State: Cancer

263
Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer's Disease in nonhuman primates

F Yue, S Feng, C Lu, T Zhang, G Tao, J Liu, C Yue, N Jing

iScience (Cell Press) China, 30 September 2021

Neuroscience

Key words: Alzheimer’s Disease, Non-Human Primate, Aβ Oligomers, Aβ Plaques, Tau Tangles, Animal Model

Organism: Monkey

Tissue: Brain

Pathological State: Alzheimer's Disease

264
Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer

LE Sima, S Chen, H Cardenas, G Zhao, Y Wang, C Ivan, H Huang, B Zhang, D Matei

Journal for ImmunoTherapy of Cancer (BMJ Journals) USA, Romania, 30 September 2021

Oncology

Organism: Mouse

Tissue: Ovaries

Pathological State: Cancer

265
Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice

MMT Islam, D Tarnowski, M Zhang, M Trum, S Lebek, J Mustroph, H Daniel, J Moellencamp, S Pabel, S Sossalla, A El-Armouche, VO Nikolaev, AM Shah, P Eaton, LS Maier, CM Sag, S Wagner

Journal of the American Heart Association (AHA Journals) Germany, Bangladesh, UK, 29 September 2021

Cardiology

Key words: Pressure Overload, Redox, Protein Kinase A, Heart Failure

Organism: Mouse

Tissue: Heart

Pathological State: Heart Failure

266
Turning up the heat on non-immunoreactive tumors: pyroptosis influences the tumor immune microenvironment in bladder cancer

X Chen, H Chen, H Yao, K Zhao, Y Zhang, D He, Y Zhu, Y Cheng, R Liu, R Xu, K Cao

Oncogene (Nature) China, Sweden, 29 September 2021

Oncology

Key words: Cancer Microenvironment, Cell Death and Immune Response, Predictive Markers

Organism: Human

Tissue: Bladder

Pathological State: Cancer

267
Adaptive metabolic responses in a thermostabilized environment: Transgenerational trade-off implications from tropical tilapia

MC Wang, MT Hsu, CC Lin, SC Hsu, RD Chen, JR Lee, YL Chou, HP Tseng, F Furukawa, SPL Hwang, PP Hwang, YC Tseng

Science of The Total Environment (Elsevier) Taiwan, Japan, 29 September 2021

Genetics, Ecology

Key words: Thermal Variance, Cold Exposure, Transgenerational Plasticity, Metabolism, Tropical Fish

Organism: Fish

Tissue: Liver

268
Human Milk Oligosaccharides alleviate stress-induced visceral hypersensitivity and associated microbiota dysbiosis

L Ferrier, H Eutamène, L Siegwald, AM Marquard, V Tondereau, J Chevalier, GE Jacot, L Favre, V Theodorou, M Vicario, A Rytz, G Bergonzelli, CL Garcia-Rodenas

The Journal of Nutritional Biochemistry (Elsevier) Switzerland, France, Denmark, 25 September 2021

Gastroenterology

Key words: HMOs, Abdominal Pain, Chronic Psychological Stress, Antibiotics, Microbiome, Metagenomic

Organism: Mouse

Tissue: Colon

269
CD8+ T effector and immune checkpoint signatures predict prognosis and responsiveness to immunotherapy in bladder cancer

X Chen, R Xu, D He, Y Zhang, H Chen, Y Zhu, Y Cheng, R Liu, R Zhu, L Gong, M Xiao, Z Wang, L Deng, K Cao

Oncogene (Nature) China, 22 September 2021

Oncology

Key words: Bladder Cancer, Immunotherapy

Organism: Human

Tissue: Bladder

Pathological State: Cancer

270
Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study

HR Jang, M Kim, S Hong, K Lee, MY Park, KE Yang, CJ Lee, J Jeon, KW Lee, JE Lee, JB Park, K Kim, GY Kwon, YG Kim, DJ Kim, W Huh

Scientific Reports (Nature) South Korea, 22 September 2021

Nephrology

Key words: Biomarkers, Kidney Diseases, Predictive Markers, Renal Replacement Therapy

Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

271
Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

P Talarska, M Boruczkowski, J Żurawski

Nanomaterials (MDPI) Poland, 21 September 2021

Nanomedicine

Key words: Silver Nanoparticles, Gold Nanoparticles, Nanotoxicology, Nanoparticle Interactions, Nanoparticle Applications

Organism: Mouse

Tissue: Brain

272
Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy

K Takamatsu, N Tanaka, K Hakozaki, R Takahashi, Y Teranishi, T Murakami, R Kufukihara, N Niwa, S Mikami, T Shinojima, T Sasaki, Y Sato, H Kume, S Ogawa, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, K Sawada, T Imamura, R Mizuno, M Oya

Nature Communications (Nature) Japan, 20 September 2021

Oncology

Key words: Cancer Immunotherapy, Cancer Microenvironment, Predictive Markers, Renal Cell Carcinoma, Tumour Biomarkers

Organism: Human

Tissue: Kidney

Pathological State: Cancer

273
PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression

XY Qin, QH Shan, H Fang, Y Wang, P Chen, ZQ Xiong, DF Swaab, JN Zhou

Acta Neuropathologica (Springer) China, The Netherlands, 18 September 2021

Neuroscience

Key words: Depression, Paraventricular Nucleus, PSD-93, Corticotropin-Releasing Hormone, Synaptic Regulation

Organism: Mouse

Tissue: Brain

Pathological State: Depression

274
Interferon Gamma-Induced Interferon Regulatory Factor 1 Activates Transcription of HHLA2 and Induces Immune Escape of Hepatocellular Carcinoma Cells

R Wang, H Guo, X Tang, T Zhang, Y Liu, C Zhang, H Yu, Y Li

Inflammation (Springer) China, 18 September 2021

Oncology, Immunology

Key words: Hepatocellular Carcinoma, HHLA2, Tumor-Associated Macrophages, PD-L1, Immune Escape, IFNG, IFR1

Organism: Human

Tissue: Liver

Pathological State: Cancer

275
Experimental nerve transfer model in the neonatal rat

ME Sporer, M Aman, KD Bergmeister, D Depisch, KM Scheuba, E Unger, BK Podesser, OC Aszmann

Neural Regeneration Research (Wolters Kluwer) Austria, 17 September 2021

Regenerative Medicine, Neuroscience

Key words: brachial plexus birth injury, experimental rat model, extremity reconstruction, methodological paper, neonatal rat, nerve reconstruction, nerve regeneration, nerve transfer, neural plasticity, peripheral nerve surgery

Organism: Rat

Tissue: Muscle

276
Multiomic analysis reveals comprehensive tumor heterogeneity and distinct immune subtypes in multifocal intrahepatic cholangiocarcinoma

SL Chen, Y Xie, Y Cai, H Hu, M He, L Liu, C Liao, Y Wang, J Wang, X Ren, Q Zeng, H Peng, S Shen, SQ Li, D Li, J Lai, B Peng, J Ren, M Kuang, S Peng

Clinical Cancer Research (AACR) China, 15 September 2021

Oncology

Key words: Multifocal Intrahepatic Cholangiocarcinoma, Heterogeneity, Clonal Evolution, Immune Microenvironment, Immunotherapy

Organism: Human

Tissue: Liver

Pathological State: Cancer

277
Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress

BG Durgin, KC Wood, SA Hahn, B McMahon, JJ Baust, AC Straub

Journal of Molecular and Cellular Cardiology (Elsevier) USA, 15 September 2021

Cardiology

Key words: Smooth Muscle Cell, Redox, Hypoxia, Nitric Oxide, Hypertrophy, Soluble Guanylyl Cyclase

Organism: Mouse

Tissue: Heart

Pathological State: Cardiac Fibrosis

278
LncRNA PVT1 knockdown ameliorates myocardial ischemia reperfusion damage via suppressing gasdermin D-mediated pyroptosis in cardiomyocytes

C Li, H Song, C Chen, S Chen, Q Zhang, D Liu, J Li, H Dong, Y Wu, Y Liu

Frontiers in Cardiovascular Medicine (Frontiers Media S.A.) China, 14 September 2021

Cardiology

Key words: lncRNA, PVT1, Myocardial Ischemia Reperfusion, Pyroptosis, Gasdermin D

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Ischemia

279
Estimating the time of skeletal muscle contusion based on the spatial distribution of neutrophils: a practical approach to forensic problems

Q Du, L Wang, D Li, J Niu, X Zhang, J Sun

International Journal of Legal Medicine (Springer) China, 13 September 2021

Biological Methods

Key words: Estimating Injury Time, Spatial Distribution, Immunohistochemical, Skeletal Muscle Contusion, Fisher Discriminant Analysis

Organism: Rat

Tissue: Bone

280
Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against …

Y Ni, BC Hu, GH Wu, ZQ Shao, Y Zheng, R Zhang, J Jin, J Hong, XH Yang, RH Sun, JQ Liu, SJ Mo

Theranostics (Ivyspring International Publisher) China, 13 September 2021

Immunology

Key words: Neutrophil extracellular traps, Fibroblast growth factor-inducible molecule 14, Macrophages, Homeobox protein Hox-A5, Septic acute kidney injury

Organism: Mouse

Tissue: Kidney

Pathological State: Sepsis

281
N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation

J Li, X Hu, T Luo, Y Lu, Y Feng, H Zhang, D Liu, X Fan, Y Wang, L Jiang, Y Wang, X Hao, T Shi, Z Wang

European Journal of Medicinal Chemistry (Elsevier) China, 10 September 2021

Biological Materials

Key words: Glioma, N-2-(Phenylamino) Benzamide, Topoisomerase I Inhibitor, COX-2 Inhibitor, Pseudocycle

Organism: Rat

Tissue: Brain

Pathological State: Cancer

282
Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

S Niu, W Shi, Y Li, S Yi, Y Li, X Liu, B Cong, G He

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 08 September 2021

Neuroscience

Organism: Rat

Tissue: Brain

283
Case Study of Noni Extract in Men with Very Low-Risk or Low-Risk Prostate Cancer

Y Hirasawa, I Pagano, JH Pharm, Y Sasaki, K Murakami, CJ Rosser, H Furuya

Hawai 'i Journal of Health & Social Welfare (hawaiijournalhealth.org) USA, 08 September 2021

Oncology

Key words: Prostate Cancer, Active Surveillance, Noni

Organism: Human

Tissue: Prostate

Pathological State: Cancer

284
Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile

H Rossiter, D Copic, M Direder, F Gruber, S Zoratto, M Marchetti-Deschmann, C Kremslehner, M Sochorova, IM Nagelreiter, V Mlitz, M Buchberger, B Lengauer, B Golabi, S Sukseree, M Mildner, L Eckhart, E Tschachler

Autophagy (Taylor & Francis) Austria, 07 September 2021

Aging

Key words: Autophagosomes, GFP-LC3, Lipid Droplets, Perilipin, Sebocytes

Organism: Mouse

Tissue: Skin

285
Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia

DR Collins, JM Urbach, ZJ Racenet, U Arshad, KA Power, RM Newman, GH Mylvaganam, NL Ly, X Lian, A Rull, Y Rassadkina, AG Yanez, MJ Peluso, SG Deeks, F Vidal, M Lichterfeld, XG Yu, GD Gaiha, TM Allen, BD Walker

Immunity (Cell Press) USA, Spain, 07 September 2021

Virology, Immunology

Key words: Human Immunology, HIV Control, CD8+ T Cell Dysfunction

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

286
Reciprocal regulation of endothelial–mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease

B Vanchin, M Sol, RAF Gjaltema, M Brinker, B Kiers, AC Pereira, MC Harmsen, JAJ Moonen, G Krenning

Scientific Reports (Nature) The Netherlands, Mongolia, Brazil, 07 September 2021

Cardiology

Key words: Cell Signalling, Epigenetics, Mechanisms of Disease, Non-Coding Rnas, Pathogenesis, Vascular Diseases

Organism: Human

Pathological State: Coronary artery disease

Cell Line: Endothelial cells

287
Elevated β-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease

L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen

Brain, Behavior, and Immunity (Elsevier) China, 06 September 2021

Neuroscience

Key words: β -Secretase, CD4+ T Cell, PGE2 Signalling, Alzheimer’s Disease, Neuroinflammation, T Cell Receptor (TCR)

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

288
PAC1 receptor mediates electroacupuncture-induced neuro and immune protection during cisplatin chemotherapy

S Li, J Huang, Y Guo, J Wang, S Lu, B Wang, Y Gong, S Qin, S Zhao, S Wang, Y Liu, Y Fang, Y Guo, Z Xu, L Ulloa

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 06 September 2021

Oncology, Pharmacology

Key words: Neuromodulation, Chemotherapy, Immunosuppression, Hematopoiesis, Neurotoxic, Electroacupuncture

Organism: Mouse

Tissue: Bone Marrow

Pathological State: Cancer

289
Decompartmentalisation as a simple color manipulation of plant-based marbling meat alternatives

S Ong, L Loo, M Pang, R Tan, Y Teng, X Lou, SK Chin,MY Naik, H Yu

Biomaterials (Elsevier) Singapore, 03 September 2021

Biological Materials, Tissue Engineering

Key words: Cell-Based Meat, Edible Scaffold, Meat Marbling, Cellulose, Polyphenol, Organoleptic

Organism: Jackfruit

290
Single‐cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer

H Lai, X Cheng, Q Liu, W Luo, M Liu, M Zhang, J Miao, Z Ji, GN Lin, W Song, L Zhang, J Bo, G Yang, J Wang, WQ Gao

International Journal of Cancer (Wiley) China, 03 September 2021

Oncology

Organism: Human

Tissue: Bladder

Pathological State: Cancer

291
Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas

C Gribben, C Lambert, HA Messal, EL Hubber, C Rackham, I Evans, H Heimberg, P Jones, R Sancho, A Behrens

Cell Stem Cell (Cell Press) UK, Belgium, Germany, 02 September 2021

Stem Cell Research

Key words: β Cells, Pancreas, Diabetes, δ Cells, Lineage Tracing, Ngn3, Progenitor, Regeneration

Organism: Mouse

Tissue: Pancreas

Pathological State: Diabetes

292
Nanostructured Lipid Carrier Gel Formulation of Recombinant Human Thrombomodulin Improve Diabetic Wound Healing by Topical Administration

YS Hsueh, YJ Shyong, HC Yu, SJ Jheng, SW Lin, HL Wu, JC Tsai

Pharmaceutics (MDPI) Taiwan, 02 September 2021

Biological Materials

Key words: Nanostructured Lipid Carrier, Protein Drug Delivery, Sustained Release, Chronic Wound Healing, Angiogenesis Factor, Carbopol Gel, Thrombomodulin

Organism: Mouse

Tissue: Skin

293
A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution

H Yang, S Yang, F Fan, Y Li, S Dai, X Zhou, CC Steiner, B Coppedge, C Roos, X Cai, DM Irwin, P Shi

Molecular Biology and Evolution (Oxford Academic) China, USA, Germany, Canada, 01 September 2021

Genetics, Evolution

Key words: Convergent Evolution, Bitter Taste Receptors, Tas2R16, Human, White-Faced Saki, Pithecia Pithecia, Adaptive Evolution

Organism: Human

Cell Line: HEK293 cells

294
Improving Mask R-CNN for Nuclei Instance Segmentation in Hematoxylin & Eosin-Stained Histological Images

B Bancher, A Mahbod, I Ellinger, R Ecker, G Dorffner

Proceedings of Machine Learning Research (PMLR) Austria, 01 September 2021

Machine Learning

Key words: Mask R-CNN, Nuclei Segmentation, Medical Image Analysis, Deep Learning, Computational Pathology

295
Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation

M Rath, A Pitiot, M Kirr, W Fröhlich, B Plosnita, S Schliep, J Bauerschmitz, AS Baur, C Ostalecki

International Journal of Molecular Sciences (MDPI) Germany, UK, Austria, 30 August 2021

Dermatology

Key words: Scar, Dendritic Cells, Tumor Microenvironment, Single-Cell Analysis, Multiplex Imaging, Proteases, Tumor Biology

Organism: Human

Tissue: Skin

Pathological State: Keloid

296
Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury

WZ Wang, X Liu, ZY Yang, YZ Wang, HT Lu

Neural Regeneration Research (Wolters Kluwer) China, 30 August 2021

Neuroscience

Key words: brain-derived neurotrophic factor, diffusion tensor imaging, fractional anisotropy value, global cerebral ischemia/reperfusion injury, hippocampus, TrkB

Organism: Rat

Tissue: Brain

297
Characteristics of Chlamydia suis Ocular Infection in Pigs

C Unterweger, A Inic-Kanada, S Setudeh, C Knecht, S Duerlinger, M Stas, D Vanrompay, C Kiekens, R Steinparzer, W Gerner, A Ladinig, T Barisani-Asenbauer

Pathogens (MDPI) Austria, Belgium, 29 August 2021

Microbiology

Key words: Chlamydia Suis, Piglets, Experimental Conjunctival Infection, Serology, Antibodies, Immunohistochemistry, Lacrimal Gland

Organism: Pig

Tissue: Eye, Lung, Colon, Testis, Kidney

Pathological State: Chlamydia Infection

298
Bone Marrow Remodelling Supports Hematopoiesis in Response to Immune Thrombocytopenia Progression in Mice

OJ Herd, GF Rani, JP Hewitson, K Hogg, AP Stone, N Cooper, DG Kent, PG Genever, IS Hitchcock

Blood Advances (Elsevier) UK, 26 August 2021

Hematology

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Immune thrombocytopenia

299
TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas

E Gonzalez-Buendia, J Zhao, L Wang, S Mukherjee, D Zhang, VA Arrieta, E Feldstein, JR Kane, SJ Kang, C Lee-Chang, A Mahajan, L Chen, R Realubit, C Karan, L Magnuson, C Horbinski, SA Marshall, JN Sarkaria, A Mohyeldin, I Nakano, M Bansal, CD James, DJ Brat, A Ahmed, P Canoll, R Rabadan, A Shilatifard, AM Sonabend

Clinical Cancer Research (AACR) USA, 25 August 2021

Oncology

Organism: Mouse

Tissue: Brain, Xenograft Tumor

Pathological State: Cancer

300
Biocompatible Copper Sulfide Based Nanocomposites for Artery Interventional Chemo-Photothermal Therapy of Orthotropic Hepatocellular Carcinoma

X Li, H Yuan, X Tian, J Tang, L Liu, F Liu

Materials Today Bio (Elsevier) China, 25 August 2021

Nanomedicine

Key words: DOX@BSA-CuS Nanocomposites, NIR-Responsive, Photothermal Ablation, Chemoembolization, MRI Guided Therapy

Organism: Rat

Tissue: Liver

Pathological State: Cancer

301
Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin

R Herzog, JM Sacnun, G González-Mateo, M Bartosova, K Bialas, A Wagner, M Unterwurzacher, IJ Sobieszek, L Daniel-Fischer, K Rusai, L Pascual-Antón, K Kaczirek, A Vychytil, C Peter Schmitt, M López-Cabrera, SL Alper, C Aufricht, K Kratochwill

Science Translational Medicine (AAAS) Austria, Spain, Germany, USA, 25 August 2021

Nephrology

Organism: Human

Tissue: Peritoneum

302
Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma

TH Hung, JT Hung, CE Wu, Y Huang, CW Lee, CT Yeh, YH Chung, FY Lo, LC Lai, JK Tung, J Yu, CN Yeh, AL Yu

Hepatology Communications (Wiley) Taiwan, 24 August 2021

Hepathology, Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

303
Oroxylin A promotes therapeutic efficacy of cisplatin to suppress bladder cancer progression via inducing ferroptosis

Q Tang, J Jiang, J Sun, L Tang, X Zhang

Biochemical and Biophysical Research Communications (Elsevier) China, 21 August 2021

Oncology, Pharmacology

Key words: Bladder Cancer, cDDP, Oroxylin A (OroA), Ferroptosis

Organism: Mouse

Tissue: Bladder

Pathological State: Cancer

304
Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity

V Azzimato, P Chen, E Barreby, C Morgantini, L Levi, A Vankova, J Jager, A Sulen, M Diotallevi, JX Shen, A Miller, E Ellis, M Rydén, E Näslund, A Thorell, VM Lauschke, KM Channon, MJ Crabtree, A Haschemi, Sm Craige, M Mori, F Spallotta, M Aouadi

Gastroenterology (Elsevier) Sweden, France, UK, Austria, Germany, USA, Italy, 21 August 2021

Gastroenterology

Key words: Liver, Metabolism, Oxidative Stress, miRNAs, Fumarase

Organism: Human

Tissue: Liver

Pathological State: Obesity

305
Spatially Resolved Immunometabolism to Understand Infectious Disease Progression

R Tans, S Dey, NS Dey, G Calder, P O'Toole, PM Kaye, RMA Heeren

Frontiers in Microbiology (Frontiers Media S.A.) The Netherlands, UK, 19 August 2021

Immunology

Key words: Immunometabolism, Infectious Disease, Inflammation, Granulomas, Mass Spectrometry Imaging, Spatial Transcriptomics, Multi-Omics, Leishmaniasis

306
Maternal Immune Activation Causes Social Behavior Deficits and Hypomyelination in Male Rat Offspring with an Autism-Like Microbiota Profile

GA Lee, YK Lin, JH Lai, YC Lo, YCSH Yang, SY Ye, CJ Lee, CC Wang, YH Chiang, SH Tseng

Brain Sciences (MDPI) Taiwan, 18 August 2021

Neuroscience

Key words: Autism Spectrum Disorder, Lipopolysaccharide, Maternal Immune Activation, Microbiota, Three-Chamber Test, Myelination, Brain–Gut–Microbiota Axis, Social Behavior Deficits

Organism: Rat

Tissue: Brain

307
Effects of Vitamin D-Deficient Diet on Intestinal Epithelial Integrity and Zonulin Expression in a C57BL/6 Mouse Model

CY Yeung, JSC Chiau, ML Cheng, WT Chan, CB Jiang, SW Chang, CY Liu, CW Chang, HC Lee

Frontiers in Medicine (Frontiers Media S.A.) Taiwan, 16 August 2021

Gastroenterology

Key words: Vitamin D, Gut Integrity, Tight Junction, Zonulin, Leaky Gut

Organism: Mouse

Tissue: Small Intestine, Colon

308
A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge

X He, L Ding, K Cao, H Peng, C Gu, Y Li, D Li, L Dong, X Hong, X Wang, M Fu, C Qiu, C Zhu, Z Zhang, S Song, C Wang, Z Jiang, Y Xie, Z Qi, C Zhao, P Zhao, X Zhang, J Xu

Emerging Microbes & Infections (Taylor & Francis) China, 12 August 2021

SARS-CoV-2

Key words: SARS-CoV-2, Cell-Based Vaccines, K562-S, Mouse Model, Non-Human Primate Model, Neutralizing Antibody, Protection

Organism: Human

Pathological State: COVID-19

Cell Line: K562 cells

309
Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus

D Douchi, A Yamamura, J Matsuo, YHM Lim, N Nuttonmanit, M Shimura, K Suda, S Chen, S Pang, K Kohu, T Abe, G Shioi, G Kim, A Shabbir, S Srivastava, M Unno, JBY So, M Teh, KG Yeoh, LSH Chuang, Y Ito

Gastroenterology (Elsevier) Singapore, Japan, 12 August 2021

Gastroenterology

Key words: Metaplasia, Intramucosal Dysplasia, Invasive and Metastatic Gastric Cancer, Gastric Carcinogenesis, Mouse Model

Organism: Mouse

Tissue: Stomach

Pathological State: Cancer

310
Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells

L Kappert, P Ruzicka, A Kutikhin, C De La Torre, A Fischer, M Hecker, C Arnold, T Korff

The FASEB Journal (Wiley) Germany, Russia, 12 August 2021

Cardiology

Organism: Human

Cell Line: Human Arterial Smooth Muscle Cells

311
The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells

PJ Kung, TY Lai, J Cao, LC Hsu, TC Chiang, P Ou-Yang, CY Tsai, YF Tsai, CW Lin, CC Chen, MK Tsai, YW Tien, CY Lee

Cancer Immunology, Immunotherpay (Springer) Taiwan, Australia, 10 August 2021

Oncology, Immunology

Key words: S100A9, PD-L1, Pancreatic Ductal Adenocarcinoma, PSC

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

312
Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer

E Shrestha, JB Coulter, W Guzman, B Ozbek, MM Hess, L Mummert, SE Ernst, JP Maynard, AK Meeker, CM Heaphy, MC Haffner, AM De Marzo, KS Sfanos

PNAS (United States National Academy of Sciences) USA, 10 August 2021

Oncology

Key words: Prostate Cancer, Infection, Inflammation, TMPRSS2:ERG Fusion, Colibactin

Organism: Human

Tissue: Prostate

Pathological State: Cancer

313
Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultraviolet Light–Induced Pterygium

CC Lai, SH Tseng, SM Hsu, YT Huang, CC Shieh

Investigative Ophthalmology & Visual Science (ARVO Journals) Taiwan, 09 August 2021

Ophthalmology

Key words: Pterygium, Pterygial Epithelial Cells, Toll-Like Receptor 3, Ultraviolet B, NF-κB

Organism: Human

Tissue: Eye

Pathological State: Pterygium

314
Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer

SC Wang, YC Chang, MY Wu, CY Yu, SL Chen, WW Sung

Cancers (MDPI) Taiwan, 04 August 2021

Oncology

Key words: Bladder Cancer, Azacitidine, Intravesical Instillation, TNF-R1, TRAIL-R2

Organism: Rat

Tissue: Bladder

Pathological State: Cancer

315
Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway

X Wu, Z Wang, Y Jiang, H Zhou, A Li, Y Wie, Z Bao, D Wang, J Zhao, X Chen, Y Guo, Z Dong, K Liu

Frontiers in Oncology (Frontiers Media S.A.) China, 04 August 2021

Oncology

Key words: Esophageal Squamous Cell Carcinoma, Tegaserod Maleate, Proteome, Peroxisome, Peroxisome Membrane Protein 11B, Peroxisome Membrane Protein 13, Patient-Derived Xenograft

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

316
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

LC Russo, R Tomasin, IA Matos, AC Manucci, ST Sowa, K Dale, KW Caldecott, L Lehtiö, D Schechtman, FC Meotti, A Bruni-Cardoso, NC Hoch

Journal of Biological Chemistry (ASBMB) Brazil, Finland, UK, 04 August 2021

SARS-CoV-2, Immunology

Key words: COVID-19, SARS-CoV-2, ADP-ribosylation, PARP9, DTX3L, macrodomain

Organism: Human

Pathological State: COVID-19

Cell Line: A549 lung adenocarcinoma cells

317
The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca2+ overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-γ/IP3R signaling pathway

T Gao, P Yang, D Fu, M Liu, X Deng, M Shao, J Liao, H Jiang, X Li

Aging (Impact Journals) China, 03 August 2021

Cardiology

Key words: Allicin, Apoptosis, PI3K/Akt Pathway, Myocardial Ischemia/Reperfusion, Gene Expression Profiling, Calcium Signaling Pathway, GRK2, GPCR

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Ischemia

318
Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma

M Ma, G Li, M Qi, W Jiang, R Zhou

Frontiers in Immunology (Frontiers Media S.A.) China, 03 August 2021

Immunology

Key words: Asthma, Inflammasome, HDM, Alveolar Macrophage, RRx-001, NLRP3

Organism: Mouse

Tissue: Lung

Pathological State: Asthma

319
High-Precision Quantitative Analysis Reveals Carcinoembryonic Protein Expression Differs Among Colorectal Cancer Primary Foci and Metastases to Different Sites

Y Zhu, Q Zhang, C Wei, Y Hu, H Gong, Y Liu, H Lai, Y Feng, Y Lin

Technology in Cancer Research & Treatment (SAGE Journals) China, 03 August 2021

Oncology

Key words: Carcinoembryonic Protein, Colorectal Cancer, Lymph Node Metastases, Liver Metastases, Primary Foci

Organism: Human

Tissue: Colon

Pathological State: Cancer

320
Conifer essential oils reversed amyloid beta1-42 action by modulating BDNF and ARC expression in the rat hippocampus

PA Postu, A Tiron, CE Tiron, DL Gorgan, M Mihasan, L Hritcu

CNS & Neurological Disorders (ingentaconnect) Romania, 30 July 2021

Neuroscience

Key words: Alzheimer’s disease, Pinus halepensis, Tetraclinis articulata, amyloid-beta peptide, memory, neuroprotection

Pathological State: Alzheimer's Disease

321
Causal evidence for induction of pessimistic decision-making in primates by the network of frontal cortex and striosomes

S Amemori, AM Graybiel, K Amemori

Frontiers in Neuroscience (Frontiers Media S.A.) Japan, USA, 30 July 2021

Neuroscience

Key words: Anxiety, Caudal Orbitofrontal Cortex, Pregenual Anterior Cingulate Cortex, Approach-Avoidance Conflict, Monkey, Microstimulation, Striosome Compartment, Caudate Nucleus

Organism: Monkey

Tissue: Brain

322
S-nitroso human serum albumin as a nitric oxide donor in drug-eluting vascular grafts: biofunctionality and preclinical evaluation

M Enayati, KH Schneider, C Almeria, C Grasl, C Kaun, B Messner, S Rohringer, I Walter, J Wojta, L Budinsky, BH Walpoth, H Schima, G Kager, S Hallström, BK Podesser, H Bergmeister

Acta Biomaterialia (Elsevier) Austria, Slovakia, Switzerland, 28 July 2021

Cardiology

Key words: Nitric Oxide Donor, Drug Eluting Vascular Graft, Poly-Caprolactone, Electrospinning

Organism: Rat

Tissue: Blood Vessels

Pathological State: Vascular Graft

323
Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV

AK Mattox, J Roelands, TM Saal, Y Cheng, D Rinchai, W Hendrickx, GD Young, TJ Diefenbach, AE Berger, WH Westra, JA Bishop, WC Faquin, FM Marincola, MJ Pittet, D Bedognetti, SI Pai

The American Journal of Pathology (Elsevier) USA, Qatar, The Netherlands, 23 July 2021

Virology

Organism: Human

Tissue: Tonsil

Pathological State: HPV Infection

324
Liposomal IR-780 as a Highly Stable Nanotheranostic Agent for Improved Photothermal/Photodynamic Therapy of Brain Tumors by Convection-Enhanced Delivery

YJ Lu, TS Anikumar, CC Chuang, JP Chen

Cancers (MDPI) Taiwan, 22 July 2021

Oncology

Key words: Nanomedicine, Cancer Therapy, Brain Tumor, Photothermal Therapy, Photodynamic Therapy, Liposome, IR-780, Convection Enhanced Delivery

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

325
Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning

WH Yang, JS Westman, DM Heithoff, M Sperandio, JW Cho, MJ Mahan, JD Marth

PNAS (United States National Academy of Sciences) USA, South Korea, Germany, 20 July 2021

Gastroenterology

Key words: Colitis, Neuraminidase, Inflammation

Organism: Mouse

Tissue: Small Intestine

Pathological State: Colitis

326
Electromagnetic Field‐Programmed Magnetic Vortex Nanodelivery System for Efficacious Cancer Therapy

X Liu, Y Zhang, Y Guo, W Jiao, X Gao, WSV Lee, Y Wang, X Deng, Y He, J Jiao, C Zhang, G Hu, XJ Liang, H Fan

Advanced Science (Wiley) China, Singapore, 18 July 2021

Nanomedicine, Oncology

Organism: Mouse

Tissue: Breast, Xenograft Tumor

Pathological State: Cancer

327
Effect of high fat diet on the severity and repair of lung fibrosis in mice

AE Hegab, M Ozaki, S Kagawa, K Fukunaga

Stem Cells and Development (Mary Ann Liebert Inc.) Japan, 16 July 2021

Endocrinology, Pulmonology

Key words: High Fat Diet, Fibrosis, Alveolar Type-2 Cells, Bronchioalveolar Stem Cells, Fatty Acid Oxidation

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

328
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

R Fardoos, OE Asowata, N Herbert, SK Nyquist, Y Zungu, A Singh, A Ngoepe, IM Mbano, N Mthabela, D Ramjit, F Karim, W Kuhn, FG Madela, VT Manzini, F Anderson, B Berger, TH Pers, AK Shalek, A Leslie, H Kløverpris

JCI Insight (The American Society for Clinical Investigation) Denmark, South Africa, USA, 12 July 2021

SARS-CoV-2

Key words: AIDS/HIV, Covid-19

Organism: Human

Tissue: Colon

Pathological State: HIV Infection

329
Down-regulation of A20 promotes immune escape of lung adenocarcinomas

K Breitenecker, M Homolya, AC Luca, V Lang, C Trenk, G Petroczi, J Mohrherr, J Horvath, S Moritsch, L Haas, M Kurnaeva, R Eferl, D Stoiber, R Moriggl, M Bilban, AC Obenauf, C Ferran, B Dome, V Laszlo, B Györffy, K Dezso, J Moldvay, E Casanova, HP Moll

Science Translational Medicine (AAAS) Austria, USA, Hungary, 07 July 2021

Oncology, Pulmonology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

330
Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle

C Romagnoli, P Sharma, R Zonefrati, G Palmini, E Lucattelli, DT Ward, I Ellinger, M Innocenti, ML Brandi

International Journal of Molecular Sciences (MDPI) Italy, UK, Austria, 06 July 2021

Osteology

Key words: Skeletal Muscle, Satellite Cells, Myogenesis, Calcium-Sensing Receptor, G Protein-Coupled Receptors

Organism: Human

Tissue: Muscle

331
Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM

KEC Blokland, H Habibie, T Borghuis, GJ Teitsma, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess

Cells (MDPI) The Netherlands, Australia, Indonesia, Canada, 29 June 2021

Pulmonology

Key words: Extracellular Matrix, Senescence, Idiopathic Pulmonary Fibrosis, Proinflammatory, Profibrotic

Organism: Human

Cell Line: Primary human lung fibroblasts

332
Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma

J Xu, N Yu, P Zhao, F Wang, J Huang, Y Cui, H Ding, Y Yang, Y Gao, L Pan, H Chang, Y Wu, B Xiang, Y Gong, X Shuai, L Hou, L Xie, T Niu, T Liu, L Zhang, W Liu, W Zhang, Y Qu, W Lin, Y Zhu, S Zhao, Y Zheng

Frontiers in Oncology (Frontiers Media S.A.) China, 29 June 2021

Oncology

Key words: Extramedullary Multiple Myeloma, MIF, Immunohistochemistry Staining, Xenograft Models, Single-Cell Sequencing

Organism: Human

Tissue: Bone Marrow

Pathological State: Cancer

333
Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo

CC Ku, K Wuputra, K Kato, JB Pan, CP Li, MH Tsai, M Noguchi, Y Nakamura, CJ Liu, TF Chan, MF Hou, S Wakana, YC Wu, CS Lin, DC Wu, KK Yokoyama

Stem Cell Research & Therapy (BMC) Taiwan, Japan, 29 June 2021

Neuroscience

Key words: Antioxidation, Cerebellum, Granule Cells, Jun Dimerization Protein 2 (Jdp2), Reactive Oxygen Species (ROS)

Organism: Mouse

Tissue: Brain

334
Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy

YX Hong, WY Wu, F Song, C Wu, GR Li, Y Wang

Aging (Impact Journals) China, 27 June 2021

Cardiology

Key words: Cardiac Senescence, Telomere Length Shortening, Mitophagy, Sirt1, Sirt6, pAMPK

Organism: Mouse

Tissue: Heart

335
Inhibition of endoplasmic reticulum stress-related autophagy attenuates MCLR-induced apoptosis in zebrafish testis and mouse TM4 cells

Z Wu, F Wang, L Hu, J Zhang, D Chen, S Zhao

Ecotoxicology and Environmental Safety (Elsevier) China, 25 June 2021

Toxicology

Key words: MCLR, Autophagy, Endoplasmic Reticulum Stress, Apoptosis, Zebrafish

Organism: Zebrafish

Tissue: Testis

336
Magneto-Activation and Magnetic Resonance Imaging of Natural Killer Cells Labeled with Magnetic Nanocomplexes for the Treatment of Solid Tumors

T Sim, B Choi, SW Kwon, KS Kim, H Choi, A Ross, DH Kim

ACS NANO (ACS Publications) USA, 24 June 2021

Nanomedicine

Key words: Natural Killer Cell, Magneto-Activation, Nanocomplexes, Cell Labeling, Cancer Therapy

Organism: Rat

Tissue: Liver

Pathological State: Cancer

337
Omega-Class Glutathione Transferases of Carcinogenic Liver Fluke, Clonorchis sinensis, Modulate Apoptosis and Differentiation of Host Cholangiocytes

CS Ahn, JG Kim, I Kang, Y Kong

Antioxidants (MDPI) South Korea, 24 June 2021

Parasitology

Key words: Clonorchis Sinensis, Omega-Class Glutathione Transferase, Cholangiocyte, Oxidative Stress, Programmed Cell Death, Cell Differentiation, Protein Kinase, Gene Regulation

Organism: Rat

Tissue: Liver

Pathological State: Clonorchis sinensis Infection

338
Hematological consequences of malaria in mice previously treated for visceral leishmaniasis

GF Rani, H Ashwin, N Brown, IS Hitchcock, PM Kaye

Wellcome Open Research (Wellcome Open Research) UK, 18 June 2021

Parasitology

Key words: visceral leishmaniasis, malaria, mouse models, hematology, chemotherapy, coinfection

Organism: Mouse

Tissue: Liver

Pathological State: Leishmaniasis

339
Investigating Transcriptional Dynamics Changes and Time-Dependent Marker Gene Expression in the Early Period After Skeletal Muscle Injury in Rats

K Ren, L Wang, L Wang, Q Du, J Cao, Q Jin, G An, Na Li, L Dang, Y Tian, Y Wang, J Sun

Frontiers in Genetics (Frontiers Media S.A.) China, 17 June 2021

Genetics

Key words: Time-Series RNA-Seq, Gene Expression and Regulation Landscape, Time-Related Biomarkers, Transcriptional Dynamics, Skeletal Muscle Injury

Organism: Rat

Tissue: Muscle

Pathological State: Skeletal Muscle Injury

340
DNA polymerase β deficiency promotes the occurrence of esophageal precancerous lesions in mice

J Qin, Y Zhu, Y Ding, T Niu, Y Zhang, H Wu, L Zhu, B Yuan, Y Qiao, J Lu, K Liu, Z Dong, G Jin, X Chen, J Zhao

Neoplasia (Elsevier) China, 15 June 2021

Oncology

Key words: Polβ, NMBA, Esophageal Precancerous Lesion

Organism: Mouse

Tissue: Esophagus

Pathological State: Cancer

341
Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

H Mathsyaraja, J Catchpole, B Freie, E Eastwood, E Babaeva, M Geuenich, PF Cheng, J Ayers, M Yu, N Wu, S Moorthi, KR Poudel, A Koehne, W Grady, AM Houghton, AH Berger, Y Shiio, D MacPherson, RN Eisenman

eLife (eLife Sciences Publications) USA, 11 June 2021

Oncology

342
Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice

NR Rao, JN Savas

Journal of Proteome Research (ACS Publications) USA, 09 June 2021

Cell Biology

Key words: Mass Spectrometry, Peptides and Proteins, Central Nervous System, Rodent Models, Endocytosis

Organism: Mouse

Tissue: Brain

343
A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL‐40‐IL‐13 Receptor α2 Axis

Y van Sleen, WF Jiemy, S Pringle, KSM van der Geest, WH Abdulahad, M Sandovici, E Brouwer, P Heeringa, AMH Boots

Arthritis & Rheumatology (Wiley) The Netherlands, Malaysia, 08 June 2021

Rheumatology

Organism: Human

Cell Line: Human microvascular endothelial cells

344
A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer

SC Chang, CS Hung, BX Zhang, TH Hsieh, W Hsu, JL Ding

Cancers (MDPI) Taiwan, 08 June 2021

Oncology

Key words: CCNF, FBXL8, FZR1, RRM2, E3 Ubiquitin Ligase, Breast Cancer, Metastasis

Organism: Human

Cell Line: BRCA cells

345
Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma

SA O'Connor, HM Feldman, S Arora, P Hoellerbauer, CM Toledo, P Corrin, L Carter, M Kufeld, H Bolouri, R Basom, J Delrow, JL McFaline-Figueroa, C Trapnell, SM Pollard, A Patel, PJ Paddison, CL Plaisier

Molecular Systems Biology (EMBO press) USA, UK, 08 June 2021

Neuroscience

Organism: Human

Cell Line: U5-HNSCs

346
Determining optimal clinical target volume margins in high-grade glioma based on microscopic tumor extension and magnetic resonance imaging

S Nie, Y Zhu, J Yang, T Xin, S Xue, X Zhang, J Sun, D Mu, Y Gao, Z Chen, X Ding, J Yu, M Hu

Radiation Oncology (BMC) China, 07 June 2021

Oncology

Key words: High-Grade Glioma, Macropathology, Microscopic Extension, Predictive Model, Clinical Target Volume, Radiotherapy

Organism: Human

Tissue: Brain

Pathological State: Cancer

347
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer

W Liu, Y Wang, Y Xie, T Dai, M Fan, C Li, Y Zou

Cell Death Discovery (Nature) China, 05 June 2021

Oncology

Key words: Cancer Microenvironment

Organism: Mouse

Tissue: Ovaries

Pathological State: Cancer

348
Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment

O Nebie, K Carvalho, L Barro, L Delila, E Faivre, TY Renn, M-Li Chou, YW Wu, A Niem-Redene, SY Chou, L Buée, CJ Hu, Chih-Wei Peng, D Devos, D Blum, T Burnouf

Brain (Oxford Academic) Taiwan, France, 04 June 2021

Neuroscience

Key words: Human Platelet Lysate, Traumatic Brain Injury, Neuroprotection, Neurorestoration, Neurotrophins

Organism: Mouse

Tissue: Brain

Pathological State: Traumatic Brain Injury

349
MoNuSAC2020: A Multi-organ Nuclei Segmentation and Classification Challenge

R Verma, N Kumar, A Patil, NC Kurian, S Rane, S Graham, QD Vu, M Zwager, SEA Raza, N Rajpoot, X Wu, H Chen, Y Huang, L Wang, H Jung, GT Brown, Y Liu, S Liu, SAF Jahromi, AA Khani, E Montahaei, MS Baghshah, H Behroozi, P Semkin, A Rassadin, P Dutande, R Lodaya, U Baid, B Baheti, S Talbar, A Mahbod, R Ecker, I Ellinger, Z Luo, B Dong, Z Xu, Y Yao, S Lv, M Feng, K Xu, H Zunair, AB Hamza, S Smiley, TK Yin, QR Fang, S Srivastava, D Mahapatra, L Trnavska, H Zhang, PL Narayanan, J Law, Y Yuan, A Tejomay, A Mitkari, D Koka, V Ramachandra, L Kini, A Sethi

IEEE Transactions on Medical Imaging (IEEE Xplore) USA, Canada, India, The Netherlands, China, USA, China, Iran, Russia, Austria, Taiwan, UAE, Slovakia, UK, 04 June 2021

Medical Image Analysis

Key words: Multi-Organ Dataset, Nucleus Classification, Computational Pathology, Instance Segmentation, Panoptic Quality

350
Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice

KP Hammer, J Mustroph, T Stauber, W Birchmeier, S Wagner, LS Maier

PLoS One (PLOS) Germany, 04 June 2021

Physiology

Key words: Exercise, Running, Arrhythmia, Mouse Models, Heterozygosity, Phosphorylation, Physical Activity, Sedentary Behavior

Organism: Mouse

Tissue: Heart

351
Synthetic Fibrin-Derived Bβ15-42 Peptide Delays Thrombus Resolution in a Mouse Model

S Chausheva, B Redwan, S Sharma, N Marella, K Schlossleitner, AC Mueller, P Petzelbauer, T Morris, IM Lang

Arteriosclerosis, Thrombosis and Vascular Biology (American Heart Association) Austria, Germany, 03 June 2021

Cardiology

Key words: Macrophages, Microvessels, Monocyte, Plasma, Venous Thrombosis

Organism: Human

Cell Line: Dermal microvascular endothelial cells

352
Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study

CE Tiron, E Patrașcanu, PA Postu, IC Vacarean Trandafir, A Tiron, I Grigoras

Current Issues in Molecular Biology (MDPI) Romania, 02 June 2021

Oncology

Key words: AKT, Breast Cancer, EMT, HIF, Sevoflurane, Vimentin

Organism: Human

Pathological State: Cancer

Cell Line: MCF-10A cells

353
Lactate modulates cellular metabolism through histone lactylation-mediated gene expression in non-small cell lung cancer

J Jiang, DL Huang, Y Jiang, J Hou, MY Tian, JH Li, Li Sun, YG Zhang, T Zhang, ZQ Li, ZC Li, SX Tong

Frontiers in Oncology (Frontiers Media S.A.) China, 02 June 2021

Oncology

Key words: Lactate, Lactylation, Metabolism, Gene Expression, Non-Small Cell Lung Cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

354
Disruption of Tfh: B cell interactions prevents antibody-mediated rejection in a kidney transplant model in rats: impact of calcineurin inhibitor dose

L Steines, H Poth, A Schuster, K Amann, B Banas, T Bergler

Frontiers in Immunology (Frontiers Media S.A.) Germany, 31 May 2021

Transplantation Medicine

Key words: Antibody-Mediated Rejection, Donor-Specific Antibodies, Kidney Transplantation, T Follicular Helper Cells, B Cell Activation, Calcineurin Inhibitor

Organism: Rat

Tissue: Kidney

Pathological State: Organ Transplantation

355
Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation

JP Hohensinner, M Lenz, P Haider, J Mayer, M Richter, C Kaun, L Goederle, M Brekalo, M Salzmann, S Sharma, MB Fischer, S Stojkovic, D Ramsmayer, C Hengstenberg, BK Podesser, K Huber, CJ Binder, J Wojta, WS Speidl

Biochemical Pharmacology (Elsevier) Austria, 28 May 2021

Endocrinology

Organism: Mouse

Tissue: Blood Vessels

356
Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma

JY Chen, WH Cheng, KY Lee, HP Kuo, KF Chung, CL Chen, BC Chen, CH Lin

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, UK, 27 May 2021

Pulmonology

Key words: Chronic Obstructive Asthma, Airway Fibrosis, ADAM17, EGFR, Human Lung Fibroblasts

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

357
Investigating the Impact of the Bit Depth of Fluorescence-Stained Images on the Performance of Deep Learning-Based Nuclei Instance Segmentation

A Mahbod, G Schaefer, C Löw, G Dorffner, R Ecker, I Ellinger

Diagnostics (MDPI) Austria, UK, 27 May 2021

Medical Image Analysis

Key words: Bit Depth, Nuclei Segmentation, Fluorescence Staining, Medical Image Analysis, Computational Pathology, Deep Learning

358
Magneto Mitochondrial Dysfunction Mediated Cancer Cell Death Using Intracellular Magnetic Nano-Transducers

W Park, SJ Kim, P Cheresh, J Yun, B Lee, DW Kamp, DH Kim

Biomaterials Science (Royal Society of Chemistry) USA, South Korea, 26 May 2021

Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

359
Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection

WF Garcia-Beltran, DT Claiborne, CR Maldini, M Phelps, V Vrbanac, ME Karpel, KL Krupp, KA Power, CL Boutwell, AB Balazs, AM Tager, M Altfeld, TM Allen

Frontiers in Immunology (Frontiers Media S.A.) USA, Germany, 26 May 2021

Immunology

Key words: Innate Immunity, T Cells, HIV-1, HuBLT, BLT, Humanized Mice

Organism: Mouse

Tissue: Spleen, Thymus

Pathological State: HIV Infection

360
Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response

I Vargova, L Machova Urdzikova, K Karova, B Smejkalova, T Sursal, V Cimermanova, K Turnovcova, CD Gandhi, M Jhanwar-Uniyal, P Jendelova

Biomedicines (MDPI) Czech Republic, USA, 24 May 2021

Regenerative Medicine, Neuroscience

Key words: Spinal Cord Injury, mTOR, Rapamycin, pp242, Dual Inhibition, Autophagy, Inflammation

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

361
Remdesivir Alleviates Acute Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome

L Yin, H Zhao, H Zhang, Y Li, Y Dong, H Ju, F Kong, S Zhao

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 21 May 2021

Immunology, Pharmacology

Key words: Remdesivir, NLRP3 Inflammasome or NOD-, LRR-, Pyrin Domain-Containing Protein 3 (NLRP3)Inflammasome, NF-κB, Macrophage, Acute Kidney Injury

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

362
Evaluation of a Novel Tilapia-skin Acellular Dermis Matrix Rationally Processed for Enhanced Wound Healing

D Li, WQ Sun, T Wang, Y Gao, J Wu, Z Xie, J Zhao, C He, M Zhu, S Zhang, P Wang, X Mo

Materials Science and Engineering: C (Elsevier) China, 21 May 2021

Tissue Engineering

Key words: Tilapia Skin, Decellularization, Wound Healing, Degradation, Re-Epithelialization

Organism: Pig, Rat

Tissue: Skin

363
Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-Based Novel Therapy against Endotoxemia in Mice

HJ Shih, CY Chang, M Chiang, VL Le, HJ Hsu, CJ Huang

Journal of Personalized Medicine (MDPI) Taiwan, Vietnam, 20 May 2021

Pharmacology

Key words: TNF-α, IL-1β, IL-6, Necroptosis, Pyroptosis, Apoptosis, Liver

Organism: Mouse

Tissue: Liver

Pathological State: Endotoxemia

364
Piezo2 downregulation via the Cre-lox system affects aqueous humor dynamics in mice

J Fang, F Hou, S Wu, Y Liu, L Wang, J Zhang, N Wang, K Wang, W Zhu

Molecular Vision (Emory University) China, 20 May 2021

Ophthalmology

Organism: Human

Tissue: Eye

365
Tissue image cytometry

A Meshcheryakova, F Mungenast, R Ecker, D Mechtcheriakova

Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 1 (IOP Publishing) Austria, 15 May 2021

Medical Image Analysis

366
Modulation of the anticancer activities of paclitaxel by Cremophor micelles

JL Chiang, YW Yang

International Journal of Pharmaceutics (Elsevier) Taiwan, 14 May 2021

Oncology

Key words: Cell Cycle, Cremophor, Micelle, Paclitaxel, Polyploidy

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

367
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo

YW Wu, MW Chao, HJ Tu, LC Chen, KC Hsu, JP Liou, CR Yang, SC Yen, WC HuangFu, SL Pan

Oncogenesis (Nature) Taiwan, China, 13 May 2021

Oncology

Key words: Drug Development, Drug Discovery and Development

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

368
Machine-perfused donor kidneys as a source of human renal endothelial cells

RGM Lammerts, LM Lagendijk, G Tiller, WA Dam, HL Lancaster, MR Daha, MA Seelen, BG Hepkema, RA Pol, HGD Leuvenink, G Molema, J van den Born, SP Berger

American Journal of Physiology (APS Journals) The Netherlands, 11 May 2021

Nephrology

Key words: Donation, Endothelial Cells, Kidney, Machine Perfusion, Perfusate, Transplantation

Organism: Human

Pathological State: Organ Transplantation

Cell Line: Cells derived from machine perfusates after kidney donation

369
Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures

YJ Wu, ME Chien, CC Chiang, YZ Huang, DM Durand, KS Hsu

Brain Stimulation (Elsevier) Taiwan, USA, 11 May 2021

Neuroscience

Key words: Seizure, Epilepsy, Electroencephalography (EEG), Oscillation, Interictal Spikes, Transcranial Direct Current Stimulation (tDCS)

Organism: Rat

Tissue: Brain

Pathological State: Chronic Seizures

370
Intravital mesoscopic fluorescence molecular tomography allows non-invasive in vivo monitoring and quantification of breast cancer growth dynamics

MS Ozturk, MG Montero, L Wang, LM Chaible, M Jechlinger, R Prevedel

Communications Biology (Nature) Turkey, Germany, 11 May 2021

Oncology

Key words: 3-D Reconstruction, Fluorescence Imaging, Molecular Imaging, Optical Imaging, Time-Lapse Imaging

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

371
Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase

W Mai, L Kong, H Yu, J Bao, C Song, G Qu

Bioscience Reports (Portland Press) China, 10 May 2021

Oncology

Key words: Human Osteosarcoma, Metastasis, Glycogen Synthase Kinase 3β

Organism: Human

Tissue: Bone

Pathological State: Cancer

372
Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation

J Kim, Y Moon

Communications Biology (Nature) South Korea, 10 May 2021

Oncology

Key words: Cancer Microenvironment, Pharmacodynamics

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

373
Dystrophin Deficiency Causes Progressive Depletion of Cardiovascular Progenitor Cells in the Heart

S Jelinkova, Y Sleiman, P Fojtík, F Aimond, A Finan, G Hugon, V Scheuermann, D Beckerova, O Cazorla, M Vincenti, P Amedro, S Richard, J Jaros, P Dvorak, A Lacampagne, G Carnac, V Rotrekl, AC Meli

International Journal of Molecular Sciences (MDPI) Czech Republic, France, 10 May 2021

Cardiology

Key words: Duchenne Muscular Dystrophy, mdx Mouse, Cardiovascular Progenitors, C-Kit, Genomic Instability, Dilated Cardiomyopathy

Organism: Mouse

Tissue: Heart

374
Neutralizing Anti-Interleukin-1 Receptor-Antagonist Autoantibodies Induce Inflammatory and Fibrotic Mediators in IgG4-Related Disease

JA Jarrell, MC Baker, CA Perugino, H Liu, MS Bloom, T Maehara, HH Wong, Tobias Lanz, JZ Adamska, S Kongpachith, J Sokolove, JH Stone, SS Pillai, WH Robinson

Journal of Allergy and Clinical Immunology (Elsevier) USA, Germany, 08 May 2021

Immunology

Key words: IL-1 Receptor-Antagonist (IL1-RA), IgG4-RD (IgG4-RD), Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), Multiple Sclerosis (MS), Immunoglobulin (Ig)

Organism: Human

Pathological State: Multiple Sclerosis

375
Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway

T Zhu, L Wang, W Xie, X Meng, Y Feng, G Sun, X Sun

Frontiers in Pharmacology (Frontiers Media S.A.) China, 07 May 2021

Pharmacology, Neuroscience

Key words: Ischemic Stroke, Notoginsenoside R1, Neurogenesis, Neurological Recovery, Oligodendrogenesis

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia, Reperfusion Injury

376
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice

YL Wang, YH Lee, YH Hsu, IJ Chiu, CCY Huang, CC Huang, ZC Chia, CP Lee, YF Lin, HW Chiu

Environmental Health Perspectives (National Institute of Environmental Health Sciences) Taiwan, 06 May 2021

Toxicology,Nephrology

Organism: Human

Cell Line: HK-2 cells

377
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration

O Guillermin, N Angelis, CM Sidor, R Ridgway, A Baulies, A Kucharska, P Antas, MR Rose, J Cordero, O Sansom, VSW Li, BJ Thompson

EMBO Journal (EMBO press) UK, Australia, 05 May 2021

Regenerative Medicine

Organism: Mouse

Tissue: Small Intestine

378
In Situ Maturated Early-Stage Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improve Cardiac Function by Enhancing Segmental Contraction in Infarcted Rats

D Biagi, ET Fantozzi, JC Campos-Oliveira, MV Naghetini, AF Ribeiro Jr, S Rodrigues, I Ogusuku, R Vanderlinde, M Lopes Araújo Christie, D Bastos Mello, AC Campos de Carvalho, M Valadares, E Cruvinel, R Dariolli

Journal of Personalized Medicine (MDPI) Brazil, Germany, USA, 04 May 2021

Cardiology, Stem Cell Research

Key words: Stem Cell-Therapy, Human Induced Pluripotent Stem Cells, Cardiomyocytes, Myocardial Infarction, Heart Failure, Regeneration, Cardiac Function

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Infarction

379
Effects of inverted photoperiods on the blood pressure and carotid artery of spontaneously hypertensive rats and Wistar–Kyoto rats

YL Wang, T Zhang, YG Zhang, Y Yu, F Bai, H Zhang, YF Chi

Journal of Hypertension (LWW Journals) China, 01 May 2021

Cardiology

Key words: Arterial Thrombosis, Atherosclerosis, Hypertension, Inverted Photoperiod

Organism: Rat

Tissue: Blood Vessels

Pathological State: Atherosclerosis, Hypertension

380
CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation

R Ajoy, YC Lo, MH Ho, YY Chen, Y Wang, YH Chen, C Jing-Yuan, CA Changou, YC Hsiung, HM Chen, TH Chang, CY Lee, YH Chiang, WC Chang, B Hoffer, SY Chou

Molecular Psychiatry (Nature) Taiwan, USA, 30 April 2021

Neuroscience

Key words: Neuroscience, Physiology

Organism: Mouse

Tissue: Brain

381
Development of a mechanically matched Silk Scaffolded 3D clear cell renal cell carcinoma model

A Abbott, K Bond, T Chiba, S Sims-Lucas, L Oxburgh, JM Coburn

Materials Science and Engineering: C (Elsevier) USA, 29 April 2021

Biological Materials

Key words: Scaffold, Mechanical Testing, Tissue Engineering, Cancer Modeling

Organism: Human

Tissue: Kidney

Pathological State: Cancer

382
Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction

M Muhuri, W Zhan, Y Maeda, J Li, A Lotun, J Chen, K Sylvia, I Dasgupta, M Arjomandnejad, T Nixon, AM Keeler, S Manokaran, R He, Q Su, PWL Tai, G Gao

Frontiers in Immunology (Frontiers Media S.A.) USA, 28 April 2021

Virology

Key words: Adeno-Associated Virus Vectors, microRNA, miR-BS, miR-142, miR-652-5p, miR-223-3p, Antigen Presenting Cells, Gene Therapy

Organism: Mouse

Tissue: Muscle

383
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

JH Choe, PB Watchmaker, MS Simic, RD Gilbert, AW Li, NA Krasnow, KM Downey, W Yu, DA Carrera, A Celli, J Cho, JD Briones, JM Duecker, YE Goretsky, R Dannenfelser, L Cardarelli, O Troyanskaya, SS Sidhu, KT Roybal, H Okada, WA Lim

Science Translational Medicine (AAAS) USA, Canada, 28 April 2021

Oncology

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

384
Minoxidil-coated lysozyme-shelled microbubbes combined with ultrasound for the enhancement of hair follicle growth: Efficacy in vitro and in vivo

AH Liao, YJ Huang, HC Chuang, CH Wang, CP Shih, CP Chiang

Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan, 27 April 2021

Pharmacology

Key words: Ultrasound, Cavitation, Lysozyme-Shelled Microbubbles, Minoxidil, Hair Follicle

Organism: Mouse

Tissue: Skin

385
Macrophages Inhibit Ciliary Protein Levels by Secreting BMP-2 Leading to Airway Epithelial Remodeling Under Cigarette Smoke Exposure

Z Wang, W Liang, C Ma, J Wang, X Gao, L Wie

Frontiers in Molecular Biosciences (Frontiers Media S.A.) China, 26 April 2021

Cell Biology

Key words: COPD, Cigarette Smoking, Macrophage, Bronchial Epithelial Cell, Ciliary Protein

Organism: Mouse

Tissue: Lung

386
Cells in the gut

T Skrzypek, K Ferenc, M Domino, J Olszewski, R Zabielski

Atlas of the Pig Gut (Elsevier) Poland, 23 April 2021

Gastroenterology

Key words: Stem Cells, Enterocytes, Goblet Cells, Enteroendocrine Cells, M Cells, Tuft Cells, Interstitial Cells of Cajal, Myocytes

387
Magnetic Fluid Hyperthermia as Treatment Option for Pancreatic Cancer Cells and Pancreatic Cancer Organoids

J Palzer, B Mues, R Goerg, M Aberle, SS Rensen, SWM Olde Damink, RDW Vaes, T Cramer, T Schmitz-Rode, UP Neumann, I Slabu, AA Roeth

International Journal of Nanomedicine (Dovepress) Germany, The Netherlands, 23 April 2021

Nanomedicine, Oncology

Key words: Magnetic Nanoparticles, SPION, Pancreatic Cancer, PDAC, Organoids, Magnetic Fluid Hyperthermia

Organism: Human

Pathological State: Cancer

Cell Line: PaCa-2 cells, PANC-1 cells

388
Augmentation of the insufficient tissue bed for surgical repair of hypospadias using acellular matrix grafts: A proof of concept study

D Morgante, A Radford, SK Abbas, E Ingham, R Subramaniam, J Southgate

Journal of Tissue Engineering (SAGE Journals) UK, 20 April 2021

Tissue Engineering

Key words: Acellular Matrix, Biomaterial, Surgery, Hypospadias Repair, Tissue Integration

Organism: Pig

Tissue: Penis

Pathological State: Hypospadias

389
Exposure-time-dependent subcellular staging of gold nanoparticles deposition and vesicle destruction in mice livers

XM Wang, XW Wu, XY Zhao, CW Wang, JN Zhou

Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier) China, 20 April 2021

Nanomedicine

Key words: Gold Nanoparticles, Biodistribution, Liver, Vesicle, Transmission Electron Microscopy

Organism: Mouse

Tissue: Liver

390
Cardiac Protection by Oral Sodium Thiosulfate in a Rat Model of L-NNA-Induced Heart Disease

ITN Nguyen, LM Wiggenhauser, M Bulthuis, JL Hillebrands, M Feelisch, MC Verhaar, H van Goor, JA Joles

Frontiers in Pharmacology (Frontiers Media S.A.) The Netherlands, UK, 15 April 2021

Pharmacology

Key words: Hydrogen Sulfide, Hypertension, ACE-Inhibitor, Cardiovascular Disease, Nitric Oxide

Organism: Rat

Tissue: Heart

Pathological State: Hypertension, Heart Disease

391
Contribution of Genetic Background to the Radiation Risk for Cancer and Non-Cancer Diseases in Ptch1+/–Mice

I De Stefano, S Leonardi, A Casciati, E Pasquali, P Giardullo, F Antonelli, F Novelli, G Babini, M Tanori, B Tanno, A Saran, M Mancuso, S Pazzaglia

Radiation Research (Radiation Research Society) Italy, 15 April 2021

Oncology

392
Persistent expression of interleukin‐17 and downstream effector cytokines in recalcitrant psoriatic lesions after ustekinumab treatment

BR Kim, M Kim, S Yang, CW Choi, KS Lee, SW Youn

The Journal of Dermatology (Wiley) South Korea, 15 April 2021

Dermatology

Key words: Cytokines, Interleukin‐17, Interleukin‐23, Psoriasis, Ustekinumab

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

393
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages

J Lv, Z Wang, Y Qu, H Zhu, Q Zhu, W Tong, L Bao, Q Lv, J Cong, D Li, W Deng, P Yu, J Song, WM Tong, J Liu, Y Liu, C Qin, B Huang

Cell discovery (Nature) China, 13 April 2021

SARS-CoV-2

Key words: Innate Immunity, Mechanisms of Disease

Organism: Mouse

Tissue: Lung

Pathological State: Covid-19

394
Enhancing Anti-Tumoral Potential of CD-NHF by Modulating PI3K/Akt Axis in U87 Ex Vivo Glioma Model

G Luta, M Butura, A Tiron, CE Tiron

International Journal of Molecular Sciences (MDPI) Romania, 08 April 2021

Oncology

Key words: Glioblastoma, Anti-Cancer Agent, Carbon Dots, EMT, Nanomedicine

Organism: Human

Cell Line: U87 cells

395
Next-Generation Digital Histopathology of the Tumor Microenvironment

F Mungenast, A Fernando, R Nica, B Boghiu, B Lungu, J Batra, RC Ecker

Genes (MDPI) Austria, Australia, Romania, 07 April 2021

Medical Image Analysis

Key words: Next-Generation Digital Histopathology, Tissue Cytometry, Multiplexing, RNA ISH, Cancer, Tumor Immune Microenvironment, Tumor Microenvironment

396
Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer

SH Park, K Fong, J Kim, F Wang, X Lu, Y Lee, LT Brea, K Wadosky, C Guo, SA Abdulkadir, JD Crispino, D Fang, P Ntziachristos, X Liu, X Li, Y Wan, DW Goodrich, JC Zhao, J Yu

Science Advances (AAAS) USA, 07 April 2021

Oncology

Organism: Human

Tissue: Prostate

Pathological State: Cancer

397
Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model

MA Plantz, S Minardi, JG Lyons, AC Greene, DJ Ellenbogen, M Hallman, JT Yamaguchi, S Jeong, C Yun, AE Jakus, KR Blank, RM Havey, M Muriuki, AG Patwardhan, RN Shah, WK Hsu, SR Stock, EL Hsu

Acta Biomaterialia (Elsevier) USA, 06 April 2021

Biological Materials

Key words: 3D Printing, Hydroxyapatite, Demineralized Bone Matrix, Bone Regeneration, Spine Fusion

Organism: Rat

Tissue: Spinal Cord

398
Therapeutic effect of modulating the NLRP3-regulated transforming growth factor-β signaling pathway on interstitial cystitis/bladder pain syndrome

HJ Shih, CY Chang, CH Lai, CJ Huang

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 01 April 2021

Pharmacology

Key words: Inflammation, Bladder, Inflammasome, Curcumin, Fibrosis

Organism: Mouse

Tissue: Bladder

Pathological State: Interstitial cystitis, Bladder pain syndrome

399
Human skin aging is associated with increased expression of the histone variant H2A. J in the epidermis

CE Rübe, C Bäumert, N Schuler, A Isermann, Z Schmal, M Glanemann, C Mann, H Scherthan

npj Aging and Mechanisms of Disease (Nature) Germany, France, 01 April 2021

Aging

Key words: Aging, Epigenetics

Organism: Mouse

Tissue: Skin

400
Single-cell sequencing reveals the transcriptome and TCR characteristics of pTregs and in vitro expanded iTregs

Z Hui, J Zhang, Y Zheng, L Yang, W Yu, Y An, F Wie, Y Ren

Frontiers in Immunology (Frontiers Media S.A.) China, 31 March 2021

Immunology

Key words: Single-Cell Sequencing, In Vitro, Regulatory T Cells, Colorectal Cancer, Chemokine Receptors

Organism: Human

Tissue: Colon

Pathological State: Cancer

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