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Customer Publications (A total of 1811 papers published)

201
Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model

A Ramírez-Fernández, L Urbina-Treviño, G Conte, M Alves, B Rissiek, A Durner, N Scalbert, J Zhang, T Magnus, F Koch-Nolte, N Plesnila, JM Deussing, T Engel, R Kopp, A Nicke

Scientific Reports (Nature) Germany, Ireland, 16 November 2020

Neuroscience

Key words: Biological techniques, Molecular biology, Neuroscience

Organism: Mouse

Tissue: Brain

202
HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age‐dependent changes

M Luque, A Schrott‐Fischer, J Dudas, E Pechriggl, E Brenner, H Rask-Andersen, W Liu, R Glueckert

Journal of Neuroscience Research (Wiley) Austria, 12 November 2020

Neuroscience

Key words: auditory development, auditory neuron diversity, axon initial segment, HCN channels, prestin, RRID:AB_90725, RRID:AB_2039906, RRID:AB_2302038, RRID:AB_2313584, RRID:AB_2313726, RRID:AB_2336419, RRID:AB_2336420, RRID:AB_2336790, RRID:AB_2340477, RRID:AB_2340452, RRID:AB_2340593, RRID:AB_2341028, RRID:AB_2617143, RRID:AB_2756625, RRID:AB_2756742, RRID:SCR_002865, RRID:SCR_013652, RRID:SCR_014823, sound coding, spiral ganglion neurons, voltage gated

Organism: Mouse, Human

203
Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

M Hara-Chikuma, M Tanaka, AS Verkman, M Yasui

Nature communications (Nature) Japan, USA, 09 November 2020

Hepathology

Key words: Molecular Drug discovery, Liver diseases, Molecular medicine

Organism: Mouse

Tissue: Bone Marrow

Pathological State: Liver Injury

204
CO2-Responsive Water-Soluble Conjugated Polymers for In Vitro and In Vivo Biological Imaging

CC Cheng, YC Lai, YT Shieh, YH Chang, AW Lee, JK Chen, DJ Lee, JY Lai

Biomacromolecules (ACS Publications) Taiwan, 06 November 2020

Medical Imaging

Organism: Zebrafish

Tissue: Whole Organism

205
Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19

Y Liu, J Lv, J Liu, M Li, J Xie, Q Lv, W Deng, N Zhou, Y Zhou, J Song, P Wang, C Qin, WM Tong, B Huang

Cell Research (Nature) China, 06 November 2020

Immunology, Covid-19

Key words: Immunology, Innate immunity

Organism: Mouse

Tissue: Lung

Pathological State: Covid-19

206
Evidence for a non-stochastic two-field hypothesis for persistent skin cancer risk

RL Konger, L Ren, RP Sahu, E Derr-Yellin, YL Kim

Scientific reports (Nature) USA, 05 November 2020

Oncology

Key words: Cancer microenvironment, Cancer models, Skin cancer, Squamous cell carcinoma

Organism: Mouse

Tissue: Skin

Pathological State: Cancer

207
Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14

R Widhalm, I Ellinger, S Granitzer, M Forsthuber, R Bajtela, K Gelles, PY Hartig, M Hengstschläger, H Zeisler, H Salzer, C Gundacker

Metallomics (Royal Society of Chemistry) Austria, 04 November 2020

Reproductive Medicine

Organism: Human

Tissue: Placenta

208
Metformin chlorination byproducts in drinking water exhibit marked toxicities of a potential health concern

R Zhang, Y He, L Yao, J Chen, S Zhu, X Rao, P Tang, J You, G Hua, L Zhang, F Ju, L Wu

Environment International (Elsevier) China, 03 November 2020

Toxicology

Key words: Metformin, Metformin chlorination byproduct, Drinking water, Toxicity, Public health

Organism: Mouse

Tissue: Small Intestine

209
Effect of route of administration on the efficacy of dendritic cell vaccine in PDAC mice

J Yang, A Eresen, J Shangguan, Q Ma, Z Zhang, V Yaghmai

American Journal of Cancer Research (e-Century Publishing Corporation) USA, 01 November 2020

Oncology

Key words: Pancreatic cancer, dendritic cell, route of administration

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

210
Therapeutic Efficacy of GC1118, a Novel Anti-EGFR Antibody, against Glioblastoma with High EGFR Amplification in Patient-Derived Xenografts

K Lee, H Koo, Y Kim, D Kim, E Son, H Yang, Y Lim, M Hur, H Won Lee, S Won Choi, DH Nam

Cancers (MDPI) South Korea, 31 October 2020

Oncology

Key words: glioblastoma, epidermal growth factor receptor, monoclonal, xenograft, amplification

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

211
P2Y2 receptor activation promotes esophageal cancer cells proliferation via ERK1/2 pathway

A Zaparte, AR Cappellari, CA Brandão, JB de Souza, TJ Borges, LW Kist, MR Bogo, LF Zerbini, LF Ribeiro Pinto, T Glaser, MCB Goncalves, Y Naaldijk, H Ulrich, FB Morrone

European Journal of Pharmacology (Elsevier) Brazil, USA, South Africa, 31 October 2020

Oncology

Key words: Esophageal cancer, Purinergic system, Nucleotide, P2Y2R, Proliferation, Signaling pathways

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

212
Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia–reperfusion injury

R Wang, M Wang, J Zhou, Z Dai, G Sun, X Sun

Journal of Advanced Research (Elsevier) China, 31 October 2020

Cardiology

Key words: Calenduloside E, myocardial ischemia-reperfusion injury, L-type calcium channelscalcium overload, Bcl2-associated athanogene 3

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

213
B Cell Activating Factor (BAFF) Is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats

L Steines, H Poth, M Herrmann, A Schuster, B Banas, T Bergler

International Journal of Molecular Sciences (MDPI) Germany, 28 October 2020

Nephrology

Key words: tertiary lymphoid organs, kidney transplantation, B cells, BAFF

Organism: Rat

Tissue: Kidney

214
Proteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model

RM Boteanu, VI Suica, L Ivan, F Safciuc, E Uyy, E Dragan, SM Croitoru, V Grumezescu, M Chiritoiu, LE Sima, C Vlagioiu, G Socol, F Antohe

Scientific reports (Nature) Romania, 28 October 2020

Osteology

Key words: Bioinformatics, Biological models, Fracture repair, Immunological techniques, Mass spectrometry, Microscopy, Proteomic analysis

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

215
Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma

Polina L. Yarova, Ping Huang, Martin W. Schepelmann, Richard Bruce, Rupert Ecker, Robert Nica, Vsevolod Telezhkin, Daniela Traini, Larissa Gomes dos Reis, Emma J. Kidd, William R. Ford, Kenneth J. Broadley, Benson M. Kariuki, Christopher J. Corrigan, Jeremy P.T. Ward, Paul J. Kemp and Daniela Riccardi

The Journal of Pharmacology and Experimental Therapeutics (ASPET) UK, Austria, Australia, 28 October 2020

Pharmacology

Organism: Mouse

Tissue: Lung

216
Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model

A Friedman, E Hueske, SM Drammis, SET Arana, ED Nelson, CW Carter, S Delcasso, RX Rodriguez, H Lutwak, KS DiMarco, Q Zhang, LI Rakocevic, D Hu, JK Xiong, J Zhao, LG Gibb, T Yoshida, CA Siciliano, TJ Diefenbach, C Ramakrishnan, K Deisseroth, AM Graybiel

Cell (Cell Press) USA, 27 October 2020

Neuroscience

Key words: corticostriatal, approach-avoidance, cost-benefit, decision-making, utility, subjective value, motivation, parvalbumin interneurons, VGluT1, excitation-inhibition balance

Organism: Mouse

Tissue: Brain

Pathological State: Huntington's Disease

217
The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer

F Mungenast, A Meshcheryakova, A Beer, M Salzmann, D Tamandl, T Gruenberger, P Pietschmann, O Koperek, P Birner, I Kirsch, H Robins, M Mittlboeck, M Jaritz, M Bergmann, P Zimmermann, D Mechtcheriakova

Cancers (MDPI) Austria, Switzerland, 25 October 2020

Oncology

Key words: lymphoid structures,  colonic mucosa,  metastatic colorectal cancer,  immuno-oncology,  B lymphocytes,  germinal center,  tissue image cytometry,  B-cell clonality,  compendium-wide analysis,  patient stratification strategy

Organism: Human

Tissue: Colon

Pathological State: Cancer

218
Cross‐section modified and highly elastic sutures reduce tissue incision and show comparable biocompatibility: in‐vitro and in‐vivo evaluation of novel thermoplastic urethane surgical threads

M Helmedag, D Heise, R Eickhoff, KM Kossel, T Gries, S Jockenhoevel, UP Neumann, CD Klink, A Lambertz

Journal of Biomedical Materials Research Part B (Wiley) Germany, 24 October 2020

Tissue Engineering

Key words: animal trials, biocompatibility, elastic sutures, surface modified surgical threads, thermoplastic polyurethane, tissue incision

Organism: Rat

Tissue: Stomach

219
Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

Noam Jacob, Kotaro Kumagai, Jay P. Abraham, Yosuke Shimodaira, Yuefang Ye, Justin Luu, Anna Y. Blackwood, Sofi L. Castanon, Dalton T. Stamps, Lisa S. Thomas, Rivkah Gonsky, David Q. Shih, Kathrin S. Michelsen & Stephan R. Targan

Scientific reports (Nature) USA, 23 October 2020

Immunology, Gastroenterology

Key words: Cytokines, Gastroenterology, Immunology, Inflammation, Inflammatory bowel disease

Organism: Mouse

Cell Line: Mouse primary colonic fibroblasts

220
Impaired autophagy increases susceptibility to endotoxin-induced chronic pancreatitis

L Xia, Z Xu, X Zhou, F Bergmann, N Grabe, MW Büchler, JP Neoptolemos, T Hackert, G Kroemer, F Fortunato

Cell death & Disease (Nature) Germany, 21 October 2020

Gastroenterology

Key words: Acute pancreatitis, Chronic pancreatitis

Organism: Mouse

Tissue: Pancreas

Pathological State: Chronic Pancreatitis

221
Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma

A Makarevic, C Rapp, S Dettling, D Reuss, C Jungk, A Abdollahi, A van Deimling, A Unterberg, C Herold-Mende, R Warta

International Journal of Molecular Sciences (MDPI) Germany, 21 October 2020

Neuroscience

Key words: lower-grade glioma, T-cell infiltration, TissueFAXS, primary tumors, recurrent tumors, radiotherapy

Organism: Human

Tissue: Brain

Pathological State: Cancer

222
Tissue remodeling macrophages morphologically dominate at the interface of polypropylene surgical meshes in the human abdomen

A Dievernich, P Achenbach, L Davies, U Klinge

Hernia (Springer) Germany, UK, 18 October 2020

Tissue Engineering

Key words: Foreign body reaction, Macrophage, Collagen, Mesh, Fluorescence microscopy

Organism: Mouse

Tissue: Stomach

223
CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy

Yuncheng Bei, Nan Cheng, Ting Chen, Yuxin Shu, Ye Yang, Nanfei Yang, Xinyu Zhou, Baorui Liu, Jia Wie, Qin Liu, Wei Zheng, Wenlong Zhang, Huifang Su, Wei‐Guo Zhu, Jianguo Ji, Pingping Shen

Advanced Science (Wiley) China, 15 October 2020

Oncology

Key words: cancer stem cells, CD44 variants, CDK5, immune checkpoint blockade, PPARγ phosphorylation, triple‐negative breast cancer, tumor microenvironment

Organism: Human

Tissue: Breast

Pathological State: Cancer

224
Poly (ADP-ribose) polymerase inhibitor treatment as a novel therapy attenuating renal ischemia-reperfusion injury

HR Jang, K Lee, J Jeon, JR Kim, JE Lee, GY Kwon, YG Kim, DJ Kim, JW Ko, W Huh

Frontiers in Immunology (Frontiers Media S.A.) South Korea, Italy, France, 14 October 2020

Immunology

Key words: Acute kidney injury, Ischemia-reperfusion injury, poly(ADP-ribose) polymerase (PARP) inhibitor, parthanatos, inflammation, translational immunology

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

225
Two Polyurethane Adhesives for PVDF Fixation Show Superior Biocompatibility in a Rat Model

D Heise, Y Mirlas, M Helmedag, R Eickhoff, A Kroh, A Lambertz, CD Klink, UP Neumann, U Klinge, R Tolba

Journal of Investigative Surgery (Taylor & Francis) Germany, The Netherlands, 14 October 2020

Tissue Engineering

Key words: Mesh fixation, polyurethane adhesive, incisional hernia

Organism: Rat

Tissue: Stomach

226
FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

L Qiu, L Hu, H Wang, J Li, X Ruan, B Sun, J Zhi, X Zheng, L Gu, M Gao, P Kong, J Zhang

Cell death & Disease (Nature) China, 09 October 2020

Oncology

Key words: Apoptosis, Macroautophagy

Organism: Human

Cell Line: Human NSCLC cell lines (A549, H520, H358, H460, H1299 and U87)

227
Immune contexture analysis in immuno‐oncology: applications and challenges of multiplex fluorescent immunohistochemistry

R Shakya, TH Nguyen, N Waterhouse, R Khanna

Clinical & Translational Immunology (Wiley) Australia, 07 October 2020

Immunology

Key words: FCS express image cytometry, immune profiling, multiplexed fluorescent immunohistochemistry, quantitative digital pathology, tumor microenvironment, vectra

228
Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring: role for AREG-induced EGFR signaling

K Lkhagvadorj, Z Zeng, J Song, M Reinders-Luinge, W Kooistra, S Song, S Krauss-Etschmann, BN Melgert, J Cao, MN Hylkema

Journal of Physiology-Lung … (American Physiological Society) The Netherlands, Mongolia, Germany, China, 06 October 2020

Pulmonology

Key words: amphiregulin, epithelial cell differentiation, lung organoids, prenatal smoke exposure

Organism: Mouse

Tissue: Lung

229
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency

Melanie Werner-Klein, Ana Grujovic, Christoph Irlbeck, Milan Obradović, Martin Hoffmann, Huiqin Koerkel-Qu, Xin Lu, Steffi Treitschke, Cäcilia Köstler, Catherine Botteron, Kathrin Weidele, Christian Werno, Bernhard Polzer, Stefan Kirsch, Miodrag Gužvić, Jens Warfsmann, Kamran Honarnejad, Zbigniew Czyz, Giancarlo Feliciello, Isabell Blochberger, Sandra Grunewald, Elisabeth Schneider, Gundula Haunschild, Nina Patwary, Severin Guetter, Sandra Huber, Brigitte Rack, Nadia Harbeck, Stefan Buchholz, Petra Rümmele, Norbert Heine, Stefan Rose-John & Christoph A. Klein

Nature Communications (Nature) Germany, Switzerland, 05 October 2020

Oncology

Key words: Breast cancer, Cancer

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

230
Innovations present in the primate interneuron repertoire

Fenna M. Krienen, Melissa Goldman, Qiangge Zhang, Ricardo C. H. del Rosario, Marta Florio, Robert Machold, Arpiar Saunders, Kirsten Levandowski, Heather Zaniewski, Benjamin Schuman, Carolyn Wu, Alyssa Lutservitz, Christopher D. Mullally, Nora Reed, Elizabeth Bien, Laura Bortolin, Marian Fernandez-Otero, Jessica D. Lin, Alec Wysoker, James Nemesh, David Kulp, Monika Burns, Victor Tkachev, Richard Smith, Christopher A. Walsh, Jordane Dimidschstein, Bernardo Rudy, Leslie S. Kean, Sabina Berretta, Gord Fishell, Guoping Feng & Steven A. McCarroll

Nature (Nature) USA, 30 September 2020

Neuroscience

Key words: Evolutionary biology, Genetics of the nervous system, Transcriptomics

Organism: Mouse

Tissue: Brain

231
Peptide-Based TNF-α-Binding Decoy Therapy Mitigates Lipopolysaccharide-Induced Liver Injury in Mice

CY Chang, HJ Hsu, J Foo, HJ Shih, CJ Huang

Pharmaceuticals (MDPI) Taiwan, 29 September 2020

Hepathology

Key words: TNF-α, necroptosis, pyroptosis, apoptosis, autophagy, mitochondrial injury

Organism: Mouse

Tissue: Liver

232
Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes

HT Wu, L Kang, YC Su, HY Ou, FY Chan, BH Su, YS Wang, CL Wu, AL Shiau, P Wu

Clinical Science (Portland Press) Taiwan, UK, 25 September 2020

Endocrinology

Key words: fibrosis, gestational diabetes, placenta, prothymosin α, trophoblast

233
A Systemic Prime–Intrarectal Pull Strategy Raises Rectum-Resident CD8+ T Cells for Effective Protection in a Murine Model of LM-OVA Infection

Q He, L Jiang, K Cao, L Zhang, X Xie, S Zhang, X Ding, Y He, M Zhang, C Zhao, X Zhang, J Xu

Frontiers in Immunology (Frontiers Media S.A.) China, 24 September 2020

Immunology

Key words: mucosal immune response, rectum TRM, prime–pull vaccination strategy, HIV, Listeria monocytogenes

Organism: Mouse

Tissue: Lung

234
Discoidin Domain Receptors 1 Inhibition Alleviates Osteoarthritis via Enhancing Autophagy

HC Chou, CH Chen, LY Chou, TL Cheng, L Kang, SC Chuang, YS Lin, ML Ho, YH Wang, SY Lin, CZ Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 23 September 2020

Rheumatology

Key words: discoidin domain receptors 1 (Ddr1), osteoarthritis (OA), autophagy, apoptosis, terminal differentiation

Organism: Mouse

Tissue: Bone

Pathological State: Osteoarthritis

235
Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury

X Zhang, Y Jing, C Qin, C Liu, D Yang, F Gao, M Yang, L Du, J Li

Journal of Cellular and Molecular Medicine (Wiley) China, 17 September 2020

Neuroscience

Key words: apoptosis, autophagic flux, decompression, mechanical stress, mTOR, spinal cord injury

Organism: Rabbit

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

236
Two common polymorphic variants of OATP4A1 as potential risk factors for colorectal cancer

Veronika Buxhofer‑Ausch, Orsolya Német, Majdah Sheikh, Hajnalka Andrikovics, Angelika Reiner, Christoph Ausch, Diana Mechtcheriakova, Attila Tordai, Andreas Gleiss, Csilla Özvegy‑laczka, Walter Jäger, Theresia Thalhammer

Oncology Letters (Spandidos Publications) Austria, Hungary, 17 September 2020

Oncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

237
Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins through BIP

J Chen, Z Chen, M Liu, T Qiu, D Feng, C Zhao, S Zhang, X Zhang, J Xu

mBio (American Society for Microbiolgy) China, 15 September 2020

Virology

Key words: BIP, placental alkaline phosphatase, Zika virus, placental trophoblast cells

Organism: Human

Cell Line: U-251 MG, JEG-3, and HK2 cells

238
IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models

SW Lu, HC Pan, YH Hsu, KC Chang, LW Wu, WY Chen, MS Chang

Nature Communications (Nature) Taiwan, 14 September 2020

Oncology

Key words: Interleukins, Pancreatic cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

239
In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP) 1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta

Sebastian Granitzer, Isabella Ellinger, Rumsha Khan, Katharina Gelles, Raimund Widhalm, Markus Hengstschläger, Harald Zeisler, Gernot Desoye, Lenka Tupova, Martina Ceckova, Hans Salzer, Claudia Gundacker

Archives of Toxicology (Springer) Austria, Czech Republic, 11 September 2020

Toxicology

Key words: Multidrug resistance-associated protein 1, Methyl mercury, HTR-8/Svneo, MDCKII, Oxidative stress, Human placenta

Organism: Human

Tissue: Placenta

240
The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix

S Taylor, M Whitfield, J Barratt, A Didangelos

The Journal of Immunology (American Association of Immnologists) UK, 11 September 2020

Immunology

Organism: Human

Tissue: Kidney

241
Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury

S Lu, Y Tian, Y Luo, X Xu, W Ge, G Sun, X Sun

Journal of Advanced Research (Elsevier) China, 09 September 2020

Cardiology

Key words: Myocardial ischemia-reperfusion, Macrophage, Iminostilbene, Pyruvate kinase M2

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

242
Integrin VLA-4 as a PET imaging biomarker of hyper-adhesion in transgenic sickle mice

Lydia A. Perkins, Lea Nyiranshuti, Lynda Little-Ihrig, Joseph D. Latoche, Kathryn E. Day, Qin Zhu, Sina Tavakoli, Prithu Sundd, Enrico M. Novelli, Carolyn J. Anderson

Blood Advances (ASH Publications) USA, 03 September 2020

Cardiology

Key words: adhesions, biological markers, diagnostic imaging, integrins, mice, monoclonal antibodies, positron-emission tomography, selectins, flow cytometry, femur

Organism: Mouse

Tissue: Bone, Spleen

243
Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis

Z Guan, Z Chen, S Fu, L Dai, Y Shen

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China, 03 September 2020

Neuroscience

Key words: Alzheimer’s disease, progranulin, Aβ, BACE1, microglia

Organism: Mouse

Tissue: Brain

244
Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft

M Enayati, S Puchhammer, J Iturri, C Grasl, C Kaun, S Baudis, I Walter, H Schima, R Liska, J Wojta, JL Toca-Herrera, BK Podesser, H Bergmeister

Journal of the Mechanical Behavior of Biomedical Materials (Elsevier) Austria, 03 September 2020

Tissue Engineering

Key words: Biodegradation, Mechanical stability, Macrophages, Thermoplastic polyurethane, Cell culture, Rat model

Organism: Rat

245
Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft

M Enayati, S Puchhammer, J Iturri, C Grasl, C Kaun, S Baudis, I Walter, H Schima, R Liska, J Wojta, JL Toca-Herrera, BK Podesser, H Bergmeister

Journal of the Mechanical Behavior of Biomedical Materials (Elsevier) Austria, 03 September 2020

Biological Materials

Key words: Biodegradation, Mechanical stability, Macrophages, Thermoplastic polyurethane, Cell culture, Rat model

246
Murine induced pluripotent stem cell‐derived neuroimmune cell culture models emphasize opposite immune‐effector functions of interleukin 13‐primed microglia and macrophages in terms of neuroimmune toxicity

A Quarta, T Meese, Z Pieters, E Van Breedam, D Le Blon, J Van Broeckhoven, S Hendrix, H Goossens, N Hens, Z Berneman, F Van Nieuwerburgh, P Ponsaerts

Glia (Wiley) Belgium, Germany, Spain, The Netherlands, 31 August 2020

Neuroscience

Key words: bioluminescence imaging, interleukin 13, iPSC, macrophages, microglia, neurotoxicity, transcriptome

Organism: Human

Cell Line: iPSC‐macrophages

247
The Secretome of Stressed Peripheral Blood Mononuclear Cells Increases Tissue Survival in a Rodent Epigastric Flap Model

Stefan Hacker, Rainer Mittermayr, Denise Traxler, Claudia Keibl, Annika Resch, Stefan Salminger, Harald Leiss, Philipp Hacker, Christian Gabriel, Bahar Golabi, Reinhard Pauzenberger, Paul Slezak, Maria Laggner, Michael Mildner, Wolfgang Michlits, Hendrik J. Ankersmit

Bioengineering & Translational Medicine (Wiley) Austria, 30 August 2020

Tissue Engineering

Key words: secretome, angiogenesis, flap surgery, necrosis reconstructive surgery, tissue regeneration

Organism: Rat

Tissue: Skin

248
Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential‐dependent NET‐formation

M Reithofer, J Karacs, J Strobl, C Kitzmüller, D Polak, K Seif, M Kamalov, CFW Becker, G Greiner, K Schmetterer

The FASEB Journal (Wiley) Austria, 29 August 2020

Cardiology

Key words: aluminium hydroxide, vaccine, adjuvant, innate response, neutrophils, NET

Organism: Human

Tissue: Skin

249
Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation

Y Zhou, M Yan, R Pan, Z Wang, X Tao, C Li, T Xia, X Liu, Q Chang

Journal of Ethnopharmacology (Elsevier) China, 28 August 2020

Neuroscience

Key words: Depression, Radix polygalae, Chronic restraint stress, Autophagy, Neuroinflammation

Organism: Mouse

Tissue: Brain

250
Topography-Mediated Myotube and Endothelial Alignment, Differentiation, and Extracellular Matrix Organization for Skeletal Muscle Engineering

AM Almonacid Suarez, MGL Brinker, LA Brouwer, I van der Ham, MC Harmsen, P van Rijn

Polymers (MDPI) The Netherlands, 28 August 2020

Tissue Engineering

Key words: myoblasts, topography, vascularization, endothelial cells, skeletal muscle, extracellular matrix

Organism: Human

Tissue: Muscle

251
Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor

L Iamartino, T Elajnaf, K Gall, J David, T Manhardt, P Heffeter, M Grusch, S Derdak, S Baumgartner-Parzer, M Schepelmann, E Kallay

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (Elsevier) Austria, 27 August 2020

Oncology

Key words: Calcium-sensing receptor, Calcimimetic, Colorectal cancer, Inflammation, Intestine

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

252
The Effects of Skin Lesion Segmentation on the Performance of Dermatoscopic Image Classification

A Mahbod, P Tschandl, G Langs, R Ecker, I Ellinger

Computer Methods and Programs in Biomedicine (Elsevier) Austria, 26 August 2020

Medical Image Analysis

Key words: Skin cancer, dermatoscopy, medical image analysis, deep learning, effect of segmentation on classification

253
Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

Jason K. Sa, Nakho Chang, Hye Won Lee, Hee Jin Cho, Michele Ceccarelli, Luigi Cerulo, Jinlong Yin, Sung Soo Kim, Francesca P. Caruso, Mijeong Lee, Donggeon Kim, Young Taek Oh, Yeri Lee, Nam-Gu Her, Byeongkwi Min, Hye-Jin Kim, Da Eun Jeong, Hye-Mi Kim, Hyunho Kim, Seok Chung, Hyun Goo Woo, Jeongwu Lee, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Jinho Kim, Woong-Yang Park, Qianghu Wang, Erik P. Sulman, Amy B. Heimberger, Michael Lim, Jong Bae Park, Antonio Iavarone, Roel G. W. Verhaak & Do-Hyun Nam

Genome Biology (BMC) South Korea, Italy, China, USA, 26 August 2020

Oncology

Organism: Human

Tissue: Brain

Pathological State: Cancer

254
Hindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption

R Gong, S Xu, A Hermundstad, Y Yu, SM Sternson

CELL (Cell Press) USA, 24 August 2020

Neuroscience

Key words: hunger, thirst, palatability, locus coeruleus, locus ceruleus, periLC, ingestive behavior, appetite, in vivo calcium imaging, GRIN lens

Organism: Mouse

255
Interruption of vascular endothelial growth factor receptor 2 signaling induces a proliferative pulmonary vasculopathy and pulmonary hypertension

Max-Paul Winter, Smriti Sharma, Johanna Altmann, Veronika Seidl, Adelheid Panzenböck, Arman Alimohammadi, Thomas Zelniker, Bassam Redwan, Felix Nagel, David Santer, Alexander Stieglbauer, Bruno Podesser, Maria Sibilia, Thomas Helbich, Gerald Prager, Aysegül Ilhan-Mutlu, Matthias Preusser, Irene M. Lang

Basic Research in Cardiology (Springer) Austria, Germany, 23 August 2020

Pulmonology

Key words: Pulmonary hypertension, VEGFR-2, FLK, Kdr, Murine model

Organism: Mouse

Tissue: Lung

256
Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19

Naoki Kaneko, Hsiao-Hsuan Kuo, Julie Boucau, Jocelyn R. Farmer, Hugues Allard-Chamard, Vinay S. Mahajan, Alicja Piechocka-Trocha, Kristina Lefteri, Matthew Osborn, Julia Bals, Yannic C. Bartsch, Nathalie Bonheur, Timothy M. Caradonna, Josh Chevalier, Fatema Chowdhury, Thomas J. Diefenbach, Kevin Einkauf, Jon Fallon, Jared Feldman, Kelsey K. Finn, Pilar Garcia-Broncano, Ciputra Adijaya Hartana, Blake M. Hauser, Chenyang Jiang, Paulina Kaplonek, Marshall Karpell, Eric C. Koscher, Xiaodong Lian, Hang Liu, Jinqing Liu, Ngoc L. Ly, Ashlin R. Michell, Yelizaveta Rassadkina, Kyra Seiger, Libera Sessa, Sally Shin, Nishant Singh, Weiwei Sun, Xiaoming Sun, Hannah J. Ticheli, Michael T. Waring, Alex L.

CELL (Cell Press) USA, Canada, 19 August 2020

SARS-CoV-2

Key words: SARS-CoV-2, COVID-19, T follicular helper cells, germinal centers, double-negative B cells, extra-follicular B cells, plasmablasts, humoral immunity, TNF-α, cytokine dysregulation

Organism: Human

Tissue: Lymphoid Tissue, Spleen

Pathological State: Covid-19

257
Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

R Vatapalli, V Sagar, Y Rodriguez, JC Zhao, K Unno, S Pamarthy, B Lysy, J Anker, H Han, YA Yoo, M Truica, ZR Chalmers, F Giles, J Yu, D Chakravarti, B Carneiro, SA Abdulkadir

Nature Communications (Nature) USA, 19 August 2020

Oncology

Key words: Epigenomics, Prostate cancer, Targeted therapies

Organism: Human

Tissue: Prostate

Pathological State: Cancer

258
Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer

V Stary, B Wolf, D Unterleuthner, J List, M Talic, J Längle, A Beer, J Strobl, G Stary, H Dolznig, M Bergman

Journal for ImmunoTherapy of Cancer (BMJ Journals) Austria, 18 August 2020

Oncology

Key words: macrophages, radiotherapy, tumor microenvironment

Organism: Human

Tissue: Colon

Pathological State: Cancer

259
Epithelial cell–specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice

HC Do-Umehara, C Chen, Q Zhang, AV Misharin, H Abdala-Valencia, SM Casalino-Matsuda, PA Reyfman, KR Anekalla, FJ Gonzalez-Gonzalez, MA Sala, C Peng, P Wu, CCL Wong, R Kalhan, A Bharat, H Perlman, KM Ridge, JI Sznajder, PHS Sporn, NS Chandel, J Yu, X Fu, I Petrache, R Tuder, GRS Budinger, J Liu

Science Advances (AAAS) USA, China, 14 August 2020

Immunology

Organism: Human

Tissue: Lung

Pathological State: Chronic obstructive pulmonary disease

260
Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring-Role for AREG-induced EGFR signaling.

K Lkhagvadorj, Z Zeng, J Song, M Reinders-Luinge, W Kooistra, S Song

American Journal of Physiology (American Physiological Society) The Netherlands, China, 12 August 2020

Pulmonology

Key words: Prenatal smoke exposure, Epithelial cell differentiation, Amphiregulin, Lung organoids

Organism: Mouse

Tissue: Lung

261
Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression

CC Lin, IY Kuo, LT Wu, WH Kuan, SY Liao, J Jen, YE Yang, CW Tang, YR Chen, YC Wang

Theranostics (Ivyspring International Publisher) Taiwan, 08 August 2020

Oncology

Key words: Lung cancer, Kras, Shh, transcription, angiogenesis

Organism: Human

Tissue: Lung

Pathological State: Cancer

262
The effects of CYP24A1 on clinicopathological features and the prognosis of pancreatic ductal adenocarcinoma

W Gao, TF Wang, W Yi, WM Tong

Translational Cancer Research (AME Publishing Company) China, 08 August 2020

Oncology

Key words: CYP24A1, pancreatic cancer, prognosis

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

263
Human FBXL8 Is a Novel E3 Ligase Which Promotes BRCA Metastasis by Stimulating Pro-Tumorigenic Cytokines and Inhibiting Tumor Suppressors

SC Chang, W Hsu, ECY Su, CS Hung, JL Ding

Cancers (MDPI) Taiwan, Singapore, 07 August 2020

Oncology

Key words: FBXL8 SCF E3 ubiquitin ligase, CCND2, IRF5, breast cancer (BRCA) and metastasis, pro-tumorigenic microenvironment

Organism: Human

Cell Line: MCF7 and MDA-MB231 cells

264
Pyramidal shaped ceria nano-biointerfaces for studying the early bone cell response

AF Bonciu, S Orobeti, LE Sima, M Icriverzi, M Filipescu, A Moldovan, A Popescu, V Dinca, M Dinescu

Applied Surface Science (Elsevier) Romania, 06 August 2020

Biological Materials

Key words: Pyramidal shaped ceria nano-biointerfaces, PLD, cells response

Organism: Human

Cell Line: Human osteosarcoma cells (SaOs-2)

265
Sodium Cholate Bile Acid-Stabilized Ferumoxytol-Doxorubicin-Lipiodol Emulsion for Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

K Kwak, B Yu, SK Mouli, AC Larson, DH Kim

Journal of Vascular and Interventional Radiology (Elsevier) USA, 06 August 2020

Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

266
Light‐emitting diode irradiation induces AKT/mTOR‐mediated apoptosis in human pancreatic cancer cells and xenograft mouse model

YM Kim, SH Ko, YI Shin, Y Kim, T Kim, J Jung, SY Lee, NG Kim, KJ Park, JH Ryu

Journal of Cellular Physiology (Wiley Online Library) South Korea, 04 August 2020

Oncology

Key words: AKT/mTOR pathway, apoptosis, LED irradiation, pancreatic cancer, tumor growth

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

267
Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

Mayank Srivastava, Ying Zhang, Jian Chen, Devika Sirohi, Andrew Miller, Yang Zhang, Zhilu Chen, Haojie Lu, Jianqing Xu, Richard J. Kuhn & W. Andy Tao

Nature communications (Nature) USA, China, 04 August 2020

Virology

Key words: Chemical tools, Proteomics, Virus–host interactions

Organism: Human

Cell Line: HEK293T cells

268
Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes

YJ Huang, TH Huang, VK Yadav, M Rachmawati Sumitra, DTW Tzeng, PL Wie, JW Shih, ATH Wu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, China, 01 August 2020

Oncology

Key words: Colon cancer stem cells, tumor microenvironment, 5-FU resistance, tumorsphere derived exosomes, β-catenin/STAT3/miR-1246 signaling, and ovatodiolide

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

269
Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells

A Yawer, E Sychrová, P Labohá, J Raška, T Jambor, P Babica, I Sovadinová

Toxicology and Applied Pharmacology (Elsevier) Czech Republic, Slovakia, 31 July 2020

Endocrinology

Key words: Connexins, Endocrine-disrupting chemicals, Gap junctional intercellular communication, Leydig cells, Reproductive toxicants, Steroidogenesis

Organism: Mouse

Cell Line: Leydig TM3 cells

270
Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin

L Molcan, A Maier, A Zemančíková, K Gelles, J Török, M Zeman, I Ellinger

Cellular and Molecular Neurobiology (Springer) Slovakia, Austria, 30 July 2020

Cardiology

Key words: Rat melatonin receptor MT1, Melatonin, Mesenteric artery (MA), Perivascular fat tissue (PVAT), Neurogenic contraction

Organism: Rat

Tissue: Eye, Brain

271
Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy

J Ye, S Lu, M Wang, W Ge, H Liu, Y Qi, J Fu, Q Zhang, B Zhang, G Sun, X Sun

Frontiers in Pharmacology (Frontiers Media S.A.) China, 30 July 2020

Cardiology

Key words: myocardial ischemia reperfusion injury, hydroxysafflor yellow A, NLRP3, autophagy, AMPK

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

272
A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model

IJ Su, HY Chang, HC Wang, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan, 30 July 2020

Neuroscience

Key words: Alzheimer’s disease therapy, curcumin analog, TML-6, aging, bioavailability

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

273
NHF-derived carbon dots: prevalidation approach in breast cancer treatment

Crina Elena Tiron, Gabriel Luta, Mihail Butura, Florin Zugun-Eloae, Corneliu S. Stan, Adina Coroaba, Elena-Laura Ursu, Gabriela Dumitrita Stanciu & Adrian Tiron

Scientific Reports (Nature) Romania, 29 July 2020

Oncology

Key words: Cancer, Drug development, Medical research, Oncology, Preclinical research, Translational research

Organism: Human

Cell Line: HUVECs and PASMCs

274
BMI1-Mediated Pemetrexed Resistance in Non-Small Cell Lung Cancer Cells Is Associated with Increased SP1 Activation and Cancer Stemness

HT Shen, PJ Chien, SH Chen, GT Sheu, MS Jan, BY Wang, WW Chang

Cancers (MDPI) Taiwan, 27 July 2020

Oncology

Key words: BMI1, SP1, pemetrexed resistance, non small cell lung cancer, cancer stem cells, epithelial–mesenchymal transition

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

275
A general method to optimize and functionalize red-shifted rhodamine dyes

JB Grimm, AN Tkachuk, L Xie, H Choi, B Mohar, N Falco, K Schaefer, R Patel, Q Zheng, Z Liu, J Lippincott-Schwartz, TA Brown, LD Lavis

Nature methods (Nature) USA, 27 July 2020

Biological Methods

Key words: Chemical biology, Chemical tools, Fluorescence imaging, Imaging

Organism: Mouse

Tissue: Brain

276
Ready to go 3D? A semi-automated protocol for microwell spheroid arrays to increase scalability and throughput of 3D cell culture testing

A Basu, A Dydowiczová, JE Trosko, L Bláha, P Babica

Toxicology Mechanisms and Methods (Taylor & Francis) Czech Republic, USA, 26 July 2020

Biological Methods

Organism: Human

Cell Line: HL1-hT1 cells and HepG2 cells

277
Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents–Implications for oxidative UV damage

C Kremslehner, A Miller, R Nica, IM Nagelreiter, MS Narzt, B Golabi, V Vorstandlechner, M Mildner, J Lachner, E Tschachler, F Ferrara, K Klavins, M Schlosserer, J Grillari, A Haschemi, F Gruber

Redox Biology (Elsevier) Austria, Italy, USA, 19 July 2020

Dermatology

Organism: Human

Tissue: Skin

278
Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets

P Haider, JB Kral-Pointner, J Mayer, M Richter, C Kaun, C Brostjan, W Ellenberg, MB Fischer, WS Spledl, C Hengstenberg, K Huber, J Wojta, P Hohensinner

Arteriosclerosis,Thrombosis, and Vascular Biology (American Heart Association) Austria, 16 July 2020

Cardiology

Key words: aortic aneurysm, extracellular traps, humans, macrophages, thrombosis

Organism: Mouse

Cell Line: Blood

279
Enterocyte-Based Bioassay via Quantitative Combination of Proinflammatory Sentinels Specific to 8-keto-trichothecenes

SH Park, Y Moon

Frontiers in Immunology (Frontiers Media S.A.) South Korea, 16 July 2020

Immunology

Key words: 8-keto-trichothecene, ribotoxic stress, inflammation, epithelium, reporter biomonitoring

Organism: Mouse

Tissue: Small Intestine

280
Pre-and post-irradiation mild hyperthermia enabled by NIR-II for sensitizing radiotherapy

Q Li, L Hang, W Jiang, J Dou, L Xiao, X Tang, Y Yao, Y Wang

Biomaterials (Elsevier) China, 14 July 2020

Biological Materials

Key words: Au nanobipyramids, Second near-infrared window, Mild hyperthermia, Radiotherapy

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

281
Antidiabetic activity in vitro and in vivo of BDB, protein tyrosine phosphatase 1B selective inhibitor from Rhodonela conferviodes

J Luo, M Zheng, B Jiang, C Li, S Guo, L Wang, X Li, R Yu, D Shi

British Journal of Pharmacology (Wiley) China, 14 July 2020

Pharmacology

Key words: Bromophenol, PTP1B inhibitor, Selectivity, Cell permeability, oral bioavailability

Organism: Mouse

Tissue: Pancreas

Pathological State: Diabetes

282
Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

D Dems, R Freeman, T Coradin, SI Stupp, C Aime

Acta Biomaterialia (SSRN) France, USA, 13 July 2020

Biological Materials

Key words: Peptide amphiphile, silica particles, nanobiocomposites, hybrid biomaterials, clustering

Organism: Mouse

Cell Line: NIH 3T3 fibroblasts

283
Lycopene Inhibit IMQ-Induced Psoriasis-Like Inflammation by Inhibiting ICAM-1 Production in Mice

CM Shih, CK Hsieh, CY Huang, CY Huang, KH Wang, TH Fong, NTT Trang, KT Liu, AW Lee

Polymers (MDPI) Taiwan, 09 July 2020

Dermatology

Key words: lycopene, psoriasis

Organism: Mouse

Tissue: Skin

Pathological State: Psoriasis

284
Using Cytometry for Investigation of Purinergic Signaling in Tumor‐Associated Macrophages

VF Arnaud‐Sampaio, ILA Rabelo, CA Bento, T Glaser, J Bezerra, R Coutinho-Silva, H Ulrich, C Lameu

Cytometry Part A (Wiley) Brazil, 07 July 2020

Oncology

Key words: macrophage, TAM, cancer stem cells, purines, ATP, purinergic system, EMT, image cytometry

Organism: Human

Pathological State: Cancer

Cell Line: Macrophages

285
Multimodal single‐cell analysis reveals distinct radioresistant stem‐like and progenitor cell populations in murine glioma

J Alexander, QC LaPlant, SS Pattwell, F Szulzewsky, PJ Cimino, FP Caruso, P Pugliese, Z Chen, F Chardon, AJ Hill, C Spurrell, D Ahrendsen, A Pietras, LM Starita, D Hambardzumyan, A Iavarone, J Shendure, EC Holland

Glia (Wiley) USA, Italy, Sweden, 04 July 2020

Neuroscience

Key words: glioma, glioma stem cells, myeloid cells, radiation response, radioresistance, single‐cell RNA sequencing, SP analysis

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

286
Catching Common Cold Virus with a Net: Pyridostatin Forms Filaments in Tris Buffer That Trap Viruses—A Novel Antiviral Strategy?

A Real-Hohn, R Zhu, H Ganjian, N Ibrahim, P Hinterdorfer, H Kowalski, D Blaas

Viruses (MDPI) Austria, Sweden, 04 July 2020

Virology

Key words: Enterovirus, Rhinovirus, pyridostatin, filament, extracellular traps

Organism: Human

Cell Line: HeLa Cells

287
Fewer tumour-specific PD-1+ CD8+ TILs in high-risk “Infiltrating” HPV− HNSCC

K Xu, Y Fu, Y Han, R Xia, S Xu, S Duan, Z Zhang, J Li

British Journal of Cancer (Nature) China, 03 July 2020

Oncology

Key words: Head and neck cancer, Tumour immunology

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

288
Slug Is A Surrogate Marker of Epithelial to Mesenchymal Transition (EMT) in Head and Neck Cancer

TB Steinbichler, J Dudas, J Ingruber, R Glueckert, S Sprung, F Fleischer, N Cidlinsky, D Dejaco, B Kofler, AI Giotakis, II Skvortsova, H Riechelmann

Journal of Clinical Medicine (MDPI) Austria, 30 June 2020

Oncology

Key words: image cytometry, p16, p53, cancer stem cells, E-cadherin, β-catenin, EMT, head and neck cancer

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

289
Functional characterization of the basal amygdala-dorsal BNST pathway during contextual fear conditioning

JS Russell, S Trouche, LG Reijmers

eNeuro (Society for Neuroscience) USA, 29 June 2020

Neuroscience

Key words: contextual fear, fear memorybasal amygdala, bed nucleus of the stria terminalis, neural circuits, encoding, fear engram

Organism: Mouse

Tissue: Brain

290
Tissues derived from reprogrammed Wharton's jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus

CM Kong, A Subramanian, SU Gan, A Biswas, B Ariff, CY Fong

Stem Cell Research (Elsevier) Singapore, 26 June 2020

Stem Cell Research

Key words: Gestational diabetes mellitus, Induced pluripotent stem cells, Reprogramming, Wharton’s jelly stem cells, Pancreatic cells

Organism: Human

Cell Line: iPSCs

291
Comparison between paramagnetic and CD71 magnetic activated cell sorting of fetal nucleated red blood cells from the maternal blood

D Nemescu, D Constantinescu, V Gorduza, A Carauleanu, L Caba, DB Navolan

Journal of Clinical Laboratory Analysis (Wiley) Romania, 25 June 2020

Biological Methods

Key words: CD71, fluorescent in situ hybridization, magnetic‐activated cell sorting, nucleated red blood cells, prenatal diagnosis

Organism: Human

Cell Line: Blood

292
BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer

YC Hsu, CW Luo, WL Huang, CC Wu, CL Chou, CI Chen, SJ Chang, CY Chai, HC Wang, TY Chen, CF Li, MR Pan

Radiotherapy and Oncology (Elsevier) Taiwan, 24 June 2020

Radiotherapy, Oncology

Key words: BMI1, CCRT, Rectal cancers, Radioresistance

Organism: Human

Tissue: Colon

Pathological State: Cancer

293
The chemokine lymphotactin and its recombinant variants in oral cancer cell regulation

AZ Abdullah Zubir, SA Whawell, TS Wong, SA Khurram

Oral Diseases (Wiley) UK, 19 June 2020

Oncology

Key words: Cancer‐associated fibroblast, Lymphotactin, Oral squamous cell carcinoma, Tumour microenvironment, XCR1

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

294
p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection

H Ishida, A Kasajima, F Fujishima, R Akaishi, S Ueki, Y Yamazaki, Y Onodera, X Gao, H Okamoto, Y Taniyama, T Kanei, H Sasano

Virchows Archiv (Springer) Japan, Australia, Germany, 16 June 2020

Oncology

Key words: Esophagus, Small-cell carcinoma, Poorly differentiated squamous cell carcinoma, Basaloid squamous cell carcinoma, p16, Human papillomavirus

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

295
Reciprocal Regulation Between Indoleamine 2, 3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells

HY Low, YC Lee, YJ Lee, HL Wang, YI Chen, PJ Chien, ST Li, WW Chang

Cancers (MDPI) Taiwan, 12 June 2020

Oncology, Stem Cell Research

Key words: IDO1, notch1, radiation, cervical cancer, cancer stem cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

296
Tumor Microenvironment Targeting Nano–Bio Emulsion for Synergistic Combinational X‐Ray PDT with Oncolytic Bacteria Therapy

W Park, S Cho, D Kang, JH Han, JH Park, B Lee, J Lee, DH Kim

Advanced Healthcare Materials (Wiley) South Korea, USA, 11 June 2020

Oncology, Nanomedicine

Key words: Bacteriolytic therapy, Nano–bio emulsions, Scintillating nanoparticles, Tumor microenvironments, X‐ray photodynamic therapy (PDT)

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

297
Regulatory T cells promote adipocyte beiging in subcutaneous adipose tissue

W Fang, Z Deng, F Benadjaoud, D Yang C Yang, GP Shi

The FASEB journal (Wiley) USA, China, 08 June 2020

Immunology

Key words: epididymal white adipose tissue, gonadal white adipose tissue, macrophage polarization, regulatory T cell, subcutaneous adipose tissue, uncoupling protein‐1

298
Yttrium-90 Radioembolization and Tumor Hypoxia: Gas-challenge BOLD Imaging in the VX2 Rabbit Model of Hepatocellular Carcinoma

AC Gordon, SB White, VL Gates, D Procissi, KR Harris, Y Yang, Z Zhang, W Li, T Lyu, X Huang, RA Omary, R Salem, RJ Lewandowski, AC Larson

Academic Radiology (Elsevier) USA, 07 June 2020

Radiotherapy, Oncology

Key words: Oxygenation, Hepatic radioembolization, Magnetic resonance imaging, Yttrium-90

Organism: Rabbit

Tissue: Kidney

Pathological State: Cancer

299
A prominent environmental endocrine disruptor, 4-nonylphenol, promotes endometriosis development via plasmacytoid dendritic cells

P Sharma, HH Tzeng, JYL Lee, EM Tsai, JL Suen

Molecular Human Reproduction (Oxford Academic) Taiwan, 04 June 2020

Reproductive Medicine

Key words: CD36, endometriosis, environmental endocrine disruptor, estrous cycle, IL-10, 4-nonylphenol, plasmacytoid dendritic cell

Organism: Mouse

Tissue: Uterus

Pathological State: Endometriosis

300
A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure

H Shawer, E Aiyelaagbe, C Clowes, SC Lean, Y Lu, KE Kadler, A Kerby, MR Dilworth, KE Hentges, AEP Heazell

PLoS One (PLOS) UK, 03 June 2020

Reproductive Medicine

Key words: Mouse models, Stillbirths, Embryos, Placenta, Fetal death, Myocardium, Heart, Giant cells

Organism: Mouse

Tissue: Placenta

301
GPRC5A reduction contributes to pollutant benzo [a] pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients

Z Huang, S Wang, Y Liu, L Fan, Y Zeng, H Han, H Zhang, X Yu, Y Zhang, D Huang, Y Wu, W Jiang, P Zhu, X Zhu, X Yi

Science of The Total Environment (Elsevier) China, 03 June 2020

Toxicology

Key words: Pulmonary fibrosis, GPRC5A, Benzo[a]pyrene pollution, Epithelium, Prognosis

Organism: Human

Tissue: Lung

Pathological State: Idiopathic non-specific interstitial pneumonia

302
AB0154 MERTK AND THE RESOLUTION OF INFLAMMATION IN IGG4-RELATED DISEASE

E Della Torre, L Rovati, A Monno, T Maehara, N Kaneko, M Lanzillotta, F Pedica, C Doglioni, S Pillai, A Manfredi

Annals of the Rheumatic Diseases (BMJ Journals) Italy, Japan, USA, 02 June 2020

Immunology

Organism: Human

Tissue: Tonsil

303
Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer

CS Lu, AL Shiau, BH Su, TS Hsu, CT Wang, YC Su, MS Tsai, YH Feng, YL Tseng, YT Yen, CL Wu, GS Shieh

Journal of Hematology & Oncology (Springer) Taiwan, 01 June 2020

Oncology

Key words: Lung cancer, Oct4, M2 macrophage, Tumor-associated macrophage, M-CSF

Organism: Human, Mouse

Tissue: Lung

Pathological State: Cancer

304
CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining

U Klinge, A Dievernich, R Tolba, B Klosterhalfen, L Davies

Journal of Biomedical Materials Research: Part B (Wiley) Germany, UK, 30 May 2020

Biological Materials

Key words: Fluorescence microscopy, Foreign body reaction, Lymphocyte, Macrophage, Mesh

Organism: Human

Tissue: Stomach

Pathological State: Abdominal Wall Hernia

305
CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease

Cory A Perugino, Naoki Kaneko, Takashi Maehara, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S Mahajan, Hang Liu, Emanuel Della-Torre, Samuel J H Murphy, Musie Ghebremichael, Zachary S Wallace, Marcy B Bolster, Liam M Harvey, Geetha Mylvaganam, Yesim Tuncay, Lloyd Liang, Sydney B Montesi, Xiuwei Zhang, Akira Tinju, Keita Mochizuki, Ryusuke Munemura, Mizuki Sakamoto, Masafumi Moriyama, Seiji Nakamura, Nir Yosef, John H Stone, Shiv Pillai

Journal of Allergy and Clinical Immunology (Mosby) USA, Japan, The Netherlands, Canada, China, Italy, 29 May 2020

Immunology

Key words: IgG4-RD, CD4+CTL, CD8+CTL, apoptosis, CD28lo, CD28(null)

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjogren syndrome

306
Caveolar communication with xenobiotic-stalled ribosomes compromises gut barrier integrity

SH Park, J Kim, Y Moon

Communications Biology (Nature) South Korea, 27 May 2020

Gastroenterology

Key words: Biomarkers, Cell Biology, Chemokines, Inflammation, Signal Transduction

Organism: Mouse

Tissue: Small Intestine

307
Interaction of different cell types with magnesium modified by plasma electrolytic oxidation

M Echeverry-Rendon, F Echeverria, MC Harmsen

Colloids and Surfaces B: Biointerfaces (Elsevier) Colombia, The Netherlands, 26 May 2020

Biological Materials

Key words: Magnesium, PEO, Adipose-derived stromal, ASC, Differentiation, Cytotoxicity

Organism: Human

Cell Line: HUVECs, ACSs

308
Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way

T Niedermair, S Schirner, RH Straub, S Grässel

Mechanisms of Ageing and  Development (Elsevier) Germany, 22 May 2020

Osteology

Key words: Bone, Osteoblast, Osteoclast, α-calcitonin gene-related peptide (α-CGRP), Osteopenia

Organism: Mouse

Tissue: Bone

309
KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation

RAF Gjaltema, D Goubert, C Huisman, C del Pilar Garcia Tobilla, M Koncz, PG Jellema, D Wu, U Brouwer, A Kiss, PJ Verschure, RA Bank, MG Rots

International Journal of Molecular Sciences (MDPI) The Netherlands, Hungary, 21 May 2020

Oncology

Key words: Pigenetic editing, KRAB, Gene repression, PLOD2, Fibrosis, Cancer

Organism: Human

Cell Line: Human skin fibroblasts

310
Synergistic effect of cell-derived extracellular matrix and topography on osteogenesis of mesenchymal stem cells

L Yang, L Ge, P van Rijn

ACS Applied Materials & Interfaces (ACS Publications) The Netherlands, 18 May 2020

Tissue Engineering

Key words: Extracellular matrix, Topography, Mesenchymal stem cells, Osteogenic differentiation, Mechanotransduction

Organism: Human

Cell Line: hBM-MSCs

311
Biomimetic Multiscale Hierarchical Topography Enhances Osteogenic Differentiation of Human Mesenchymal Stem Cells

L Yang, L Ge, Q Zhou, T Mokabber, Y Pei, R Bron, P van Rijn

Advanced Materials Interfaces (Wiley) The Netherlands, China, 13 May 2020

Stem Cell Research

Key words: collagen, extracellular matrix, hierarchical topography, human mesenchymal stem cells, mechanotransduction, osteogenic differentiation

Organism: Human

Cell Line:  hBM‐MSCs

312
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome

Kim L. Brunekreeft, Sterre T. Paijens, Maartje C.A. Wouters, Fenne L. Komdeur, Florine A. Eggink, Joyce M. Lubbers, Hagma H. Workel, Elisabeth C. Van Der Slikke, Noor E.J. Pröpper, Ninke Leffers, Julien Adam, Harry Pijper, Annechien Plat, Arjan Kol, Hans W. Nijman, Marco De Bruyn

OncoImmunology (Taylor & Francis) The Netherlands, France, Canada, 13 May 2020

Oncology, Immunology

Key words: Epithelial ovarian cancer, chemotherapy, tumor microenvironment, cancer immunology, MHC-I

Organism: Human

Tissue: Ovaries, Lymphoid Tissue

Pathological State: Cancer

313
Progesteron receptor expression in insulin producing cells of neuroendocrine neoplasms

T Tachibana, A Kasajima, T Aoki, T Tabata, K McNamara, S Yazdani, S Satoko, F Fujishima, F Motoi, M Unno, H Sasano

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Japan, Germany, 11 May 2020

Endocrinology

Key words: Neuroendocrine neoplasm, Insulinoma, Progesteron receptor

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

314
Decoupling the Amplitude and Wavelength of Anisotropic Topography and the Influence on Osteogenic Differentiation of Mesenchymal Stem Cells Using a High-Throughput Screening Approach

L Yang, L Ge, Q Zhou, K Jurczak, P van Rijn

ACS Applied Bio Materials (ACS Publications) The Netherlands, China, 06 May 2020

Stem Cell Research

Organism: Human

Cell Line: hBM-MSCs

315
Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program

Massimo Granai, Lucia Mundo, Ayse U. Akarca, Maria Chiara Siciliano, Hasan Rizvi, Virginia Mancini, Noel Onyango, Joshua Nyagol, Nicholas Othieno Abinya, Ibrahim Maha, Sandra Margielewska, Wenbin Wi, Michele Bibas, Pier Paolo Piccaluga, Leticia Quintanilla-Martinez, Falko Fend, Stefano Lazzi, Lorenzo Leoncini, Teresa Marafioti

Infectious Agents and Cancer (BMC) Italy, Germany, UK, Kenya, Egypt,, 06 May 2020

Oncology, Virology

Key words: Burkitt lymphoma, Tumour microenvironment, EBV, PD-L1, Immunotherapy, Immune checkpoint

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

316
High‐Throughput Screening and Hierarchical Topography‐Mediated Neural Differentiation of Mesenchymal Stem Cells

L Yang, KM Jurczak, L Ge, P van Rijn

Advanced Healthcare Materials (Wiley Online Library) The Netherlands, 04 May 2020

Stem Cell Research

Key words: anisotropic topography, hierarchical structures, high‐throughput screening, human mesenchymal stem cells, neural differentiation

Organism: Human

Cell Line: hMSCs

317
The Prognostic and Predictive Value of SOX2+ Cell Densities in Patients Treated for Colorectal Cancer

TJ Miller, MJ McCoy, TF Lee-Pullen, CC Anyaegbu, C Hemmings, MK Bulsara, CF Platell

Cancers (MDPI) Australia, 29 April 2020

Oncology

Key words: SOX2, colorectal cancer, chemotherapy, prognosis, oxaliplatin, 5-fluorouracil, cancer stem cell

Organism: Human

Tissue: Colon

Pathological State: Cancer

318
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research

Talita Glaser, Hiromi Shimojo, Deidiane Elisa Ribeiro, Patrícia Pereira Lopes Martins, Renata Pereira Beco, Michal Kosinski, Vanessa Fernandes Arnaud Sampaio, Juliana Corrêa-Velloso, Ágatha Oliveira-Giacomelli, Claudiana Lameu, Ana Paula de Jesus Santos, Héllio Danny Nóbrega de Souza, Yang D. Teng, Ryoichiro Kageyama & Henning Ulrich

Molecular Psychiatry (Nature) Japan, Brazil, USA, Poland, 29 April 2020

Cell Biology, Neuroscience

Key words: Cell biology, Diseases, Molecular biology, Neuroscience

Organism: Mouse

Cell Line: E14Tg2A cells

319
Acute Effects of Pulmonary Exposure to Zinc Oxide Nanoparticles on Brain in Vivo 2

HC Chuang, YT Yang, HC Chen, YH Hwang, KY Wu, TF Chen, CL Chen, MK Jhan, TJ Cheng

Aerosol and Air Quality Research (AAQR) Taiwan, 25 April 2020

Nanomedicine

Key words: Autophagy, Central nervous system, Elevated plus maze, Morris water maze, Nanoparticle, Ubiquitin.

Organism: Rat

Tissue: Brain

320
A characteristic expression pattern of core circadian genes in the diurnal tree shrew

PH Luo, YM Shu, RJ Ni, YJ Liu, JN Zhou

Neuroscience (Elsevier) China, 25 April 2020

Neuroscience

Key words: tree shrew, diurnal animal, circadian gene, brain rhythm, peripheral rhythm

Organism: Tree Shrew

Tissue: Brain

321
In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique

SC Liao, CY Chen, YH Hsu, CT Li, CC Hsieh, MS Tsai, MY Chan, CH Lee, SH Wang, SK NG, HK Tsou, WY Wu

Surface and Coatings Technology (Elsevier) Taiwan, 21 April 2020

Biological Materials

Key words: HiPIMS, TiN, Acrylamide crosslinking, BMP2 attachment, in vitro and in vivo studies

Organism: Mouse

Tissue: Skin

322
Characterization of CD103+ CD8+ tissue‑resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti‑PD‑1 blockade

L Han, QL Gao, XM Zhou, C Shi, GY Chen, YP Song, YJ Yao, YM Zhao, XY Wen, SL Liu, YM Qi, YF Gao

Cancer Immunology, Immunotherpay (Springer) China, 20 April 2020

Oncology, Immunology

Key words: CD103, Tissue-resident T cells, Tumor-infiltrating lymphocytes, Esophageal squamous cell carcinoma

Organism: Mouse

Tissue: Skin

Pathological State: Cancer

323
The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos

ZY Chen, NJ Li, FY Cheng, JF Hsueh, CC Huang, FI Lu, TF Fu, SJ, Yan, YH Lee, YJ Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 20 April 2020

Nanomedicine

Key words: zebrafish embryos, acute toxicity, silver nanoparticles, chorion pore size, lysosomal activity, apoptosis

Organism: Zebrafish

Tissue: Whole Organism

324
Macrophages and Fibroblasts Differentially Contribute to Tattoo Stability

H Strandt, O Voluzan, T Niedermair, U Ritter, J Thalhamer, B Malissen, A Stoeklinger, S Henri

Dermatology (Karger) France, Germany, 19 April 2020

Dermatology

Key words: Tattoo, Macrophage, Fibroblast, Tattoo maintenance

Organism: Human

Tissue: Skin

325
Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit

KH Kim, SJ Lee, J Kim, Y Moon

iScience (Cell Press) South Korea, 18 April 2020

Cell Biology

Key words: CTGF/CCN2, Wnt, Ribosomal insult, Colorectal cancer, Tumor niche

Organism: Human

Cell Line: HCT8 and HCT116 cells

326
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma

JR Podojil, AP Glaser, D Baker, ET Courtois, D Fantini, Y Yu, V Eaton, S Sivajothi, M Chiang, A Das, KA McLauglin, P Robson, SD Miller, JJ Meeks

OncoImmunology (Taylor & Francis) USA, 16 April 2020

Oncology, Immunology

Key words: Immunotherapy, bladder cancer, macrophage, T cell, checkpoint inhibitor

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

327
Functional diversity between HSP70 paralogs due to variable interactions with specific co-chaperones.

D Serlidaki, MAWH van Waarde, L Rohland, AS Wentink, SL Dekker, MJ Kamphuis, JM Boertien, JF Brunsting, NB Nillegoda, B Bukau, MP Mayer, HH Kampinga, S Bergink

Journal of Biological Chemistry (ASBMB) The Netherlands, Germany, 13 April 2020

Cell Biology

Key words: Hsp110 , HSPA4, HSPH2, protein folding, superoxide dismutase (SOD), 70 kilodalton heat shock protein (Hsp70), proteostasis amyotrophic lateral sclerosis (ALS) (Lou Gehrig disease), heat shock protein (HSP)

Organism: Human

Cell Line: HEK293 Cells

328
IFN-κ suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis

Y He, W Fu, K Cao, Q He, X Ding, J Chen, L Zhu, T Chen, L Ding, Y Yang, C Zhu, S Yuan, Z Li, C Zhao, X Zhang, J Xu

Science Signaling (AAAS) China, 07 April 2020

Immunology

Organism: Mouse

Tissue: Lung

329
EMI2 expression as a poor prognostic factor in patients with breast cancer

A Vadhan, YY Wang, SSF Yuan, YC Lee, SCS Hu, JY Huang, T Ishikawa, MF Hou

Kaohsiung Journal of Medical Sciences (Wiley) Taiwan, Japan, 06 April 2020

Oncology

Key words: breast cancer, EMI2 (FBXO43), metastasis

330
Topography induced stiffness alteration of stem cells influences osteogenic differentiation

L Yang, Q Gao, L Ge, Q Zhou, EM Warszawik, R Bron, KW Lai, P van Rijn

Biomaterials Science (Royal Society of Chemistry) The Netherlands, China, 05 April 2020

Stem Cell Research

Organism: Human

Cell Line: hBM-MSCs

331
Loss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis

S Lee, HS Roh, SS Song, J Shin, J Lee, DH Bhang,BG Kim, SH Um, HS Jeong, KH Baek

Translational Oncology (Elsevier) South Korea, 03 April 2020

Oncology

Organism: Human

Cell Line: Endothelial Cells

332
Anti-apoptotic molecule BCL2 is a therapeutic target in steroid-refractory graft-versus-host disease

J Strobl, RV Pandey, T Kausgruber, L Kleißl, B Reininger, M Herac, N Bayer, C Krall, P Wohlfarth, M Mitterbauer, P Kalhs, W Rabitsch, C Bock, G Hopfinger, G Stary

Journal of Investigative  Dermatology (Elsevier) Austria, 02 April 2020

Dermatology

Organism: Human

Tissue: Skin

333
Thyrotropin receptor signaling deficiency impairs spatial learning and memory in mice

S Luan, W Bi, S Shi, L Peng, Z Li, J Jiang, L Gao, Y Du, X Hou, Z He, J Zhao

Journal of Endocrinology (Society for Endocrinology) China, 01 April 2020

Endocrinology

334
Distinct galectin profile in inflammation-mediated cartilage damage

S Hayer, B Niederreiter, R Windhager, D Aletaha, HJ Gabius, S Toegel

Osteoarthritis and Cartilage (OARSI Journal) Austria, 01 April 2020

Osteology

Organism: Mouse

Tissue: Cartilage, Bone

Pathological State: Arthritis

335
Anti-VEGF Treatment Enhances CD8+ T-Cell Antitumor Activity by Amplifying Hypoxia

Patricia E de Almeida, Judy Mak, Genevive Hernandez, Rajiv Jesudason, Aurelie Herault, Vincent Javinal, Jovencio Borneo, Jeong M Kim and Kevin Barry Walsh

Cancer Immunology Research (AACR) USA, 27 March 2020

Oncology

Key words: VEGF, CD8+ T cells, hypoxia, angiogenesis, hypoxia-inducible factor-1

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

336
Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling

KY Lee, PW Shueng, CM Chou, BX Lin, MH Lin, DY Kuo, IL Tsai, SM Wu, CW Lin

Cancer Science (Japanese Cancer Association) Taiwan, 25 March 2020

Oncology

Key words: CD109, EGFR, lung cancer, metastasis, mTOR

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

337
Functionalized graphene oxide thin films for anti-tumor drug delivery to melanoma cells

LE Sima, G Chiritoiu, I Negut, V Grumezescu, S Orobeti, CVA Munteanu, F Sima, E Axente

Frontiers in Chemistry (Frontiers Media S.A.) Romania, 25 March 2020

Nanomedicine

Organism: Human

Cell Line: HDF cells, NHEM cells

338
Advancements in developing an effective and preventive dengue vaccine

K Zahid, S Shakoor, HA Sajid, S Afzal, L Ali, I Amin, M Shahid, M Idrees

Future Virology (Future Medicine) Pakistan, 24 March 2020

Virology

Key words: aedes mosquito, chimeric vaccine, dengue fever, dengue virus, endemic, pandemic, public health, subtropical, tropical, vaccines

339
Iron and advanced glycation end products: Emerging role of iron in androgen deficiency in obesity

SH Chen, KC Yuan, YC Lee, CK Shih, SH Tseng, AA Tinkov, AV Skalny, JS Chang

Antioxidants (MDPI) Taiwan, 22 March 2020

Endocrinology

Key words: obesity, iron, fat, advanced glycation end products, testis, testosterone

Organism: Rat

Tissue: Liver, Testis

Pathological State: Obesity

340
Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors

HM Tran, KS Wu, SY Sung, CA Changou, TH Hsieh, YR Liu, YL Liu, ML Tsai, HL Lee, KL Hsieh, WC Huang, ML Liang, HH Chen, YY Lee, SC Lin, DM Ho, FC Chang, ME Chao, W Chen, SS Chu, AL Yu, Y Yen, CC Chang, TT Wong

Cancers (MDPI) Taiwan, Vietnam, 22 March 2020

Oncology

Key words: Myc-ATRTs, protein synthesis, proteasome degradation, bortezomib, p53

Organism: Human, Mouse

Tissue: Brain, Xenograft Tumor

341
Soluble Alpha-Klotho Alleviates Cardiac Fibrosis without Altering Cardiomyocytes Renewal

WY Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 22 March 2020

Cardiology

Key words: klotho, FGF-23, cardiac fibrosis, genetic fate mapping

Organism: Mouse

Tissue: Heart

342
Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion

AN Vidyanti, JY Hsieh, KJ Lin, YC Fang, I Setyopranoto, CJ Hu

International Journal of Molecular Sciences (MDPI) Taiwan, 21 March 2020

Neuroscience

Key words: vascular cognitive impairment, chronic cerebral hypoperfusion, modified bilateral common carotid artery occlusion, HMGB1

Organism: Mouse

Tissue: Brain

343
Analysis of sensitivity and specificity: precise recognition of neutrophils during regeneration of contused skeletal muscle in rats

J Niu, G An, Z Gu, P Li, Q Liu, R Bai, J Sun, Q Du

Forensic Sciences Research (Taylor & Francis) China, 19 March 2020

Neuroscience

Key words: Forensic sciences, forensic pathology, immunohistochemistry, TissueFAXS 200 digital pathological analysis system, parameter optimization, cut-off value of staining area, neutrophil staining area

Organism: Rat

Tissue: Muscle

344
Autophagy attenuates high glucose-induced oxidative injury to lens epithelial cells

X Liu, X Zhao, R Cheng, Y Huang

Bioscience Reports (Portland Press) China, 18 March 2020

Endocrinology

Key words: diabetic cataract, high glucose, autophagy, oxidative stress, lens

Organism: Mouse

Tissue: Eye

345
MeCP2 mediates transgenerational transmission of chronic pain

W Tao, C Chen, Y Wang, W Zhou, Y Jin, Y Mao, H Wang, L Wang, W Xie, X Zhang, J Li, J Li, X Li, ZQ Tang, C Zhou, ZZ Pan, Z Zhang

Progress in Neurobiology (Elsevier) China, USA, 18 March 2020

Neuroscience

Key words: Chronic pain, MeCP2, Primary somatosensory cortex, Glutamatergic neuron, Transgenerational transmission

Organism: Mouse

Tissue: Brain

346
Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation

Chia-Chen Ku, Kenly Wuputra, Kohsuke Kato, Wen-Hsin Lin, Jia-Bin Pan, Shih-Chieh Tsai, Che-Jung Kuo, Kan-Hung Lee, Yan-Liang Lee, Ying-Chu Lin, Shigeo Saito, Michiya Noguchi, Yukio Nakamura, Hiroyuki Miyoshi, Richard Eckner, Kyosuke Nagata, Deng-Chyang Wu, Chang-Shen Lin & Kazunari K. Yokoyama

Scientific Reports (Nature) Taiwan, Japan, 18 March 2020

Neuroscience

Key words: Apoptosis, Molecular neuroscience

Organism: Mouse

Tissue: Brain

347
Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APC Min/+ mice

L Szeponik, P Akeus, W Rodin, S Raghavan, M Quiding-Järbrink

Cancer Immunology, Immunotherpay (Springer) Sweden, 17 March 2020

Immunology

Key words: Regulatory T cells, APCmin/+, Colon cancer, Tumor-infiltrating lymphocytes, Anti-tumor immunity

Organism: Mouse

Tissue: Small Intestine

Pathological State: Cancer

348
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

Shi-Ting Li, De Huang, Shengqi Shen, Yongping Cai, Songge Xing, Gongwei Wu, Zetan Jiang, Yijie Hao, Mengqiu Yuan, Nana Wang, Lianbang Zhu, Ronghui Yan, Dongdong Yang, Lin Wang, Zhaoji Liu, Xin Hu, Rongbin Zhou, Kun Qu, Ailing Li, Xiaotao Duan, Huafeng Zhang & Ping Gao

Nature Metabolism (Nature) China, 16 March 2020

Oncology

Key words: Cancer, Cancer metabolism, Cell growth

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

349
Long-Term Deleterious Effects of Short-term Hyperoxia on Cancer Progression—Is Brain-Derived Neurotrophic Factor an Important Mediator? An Experimental Study

A Tiron, I Ristescu, PA Postu, CE Tiron, F Zugun-Eloae, I Grigoras

Cancers (MDPI) Romania, 14 March 2020

Oncology

Key words: cancer progression, breast cancer, hyperoxia, perioperative, metastasis, BDNF, Vimentin, E-Cadherin, epithelial mesenchymal transition, angiogenesis

Cell Line: human MDA-MB-231 and murine 4T1 TNBC cell lines

350
Proteomic profiling of hepatic stellate cells in alcohol liver fibrosis reveals proteins involved in collagen production

L Yin, Y Zhang, H Shi, Y Feng, L Zhang

Alcohol (Elsevier) China, 12 March 2020

Hepathology

Key words: Ethanol, Liver, HSC, Proteomics, collagen, Ndufv2

Organism: Rat

Tissue: Liver

Pathological State: Liver Fibrosis

351
Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction

Cody Rutledge, George Cater, Brenda McMahon, Lanping Guo, Seyed Mehdi Nouraie, Yijen Wu, Flordeliza Villanueva & Brett A. Kaufman

Cardiovascular Ultrasound (BMC) USA, 12 March 2020

Cardiology

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Infarction

352
Placental Morphology and Cellular Characteristics in Stillbirths in Women With Diabetes and Unexplained Stillbirths

A Kerby, D Shingleton, G Batra, MC Sharps, BC Baker, AEP Heazell

Archives of Pathology & Laboratory Medicine (College of American Pathologists) UK, 09 March 2020

Reproductive Medicine

Organism: Human

Tissue: Placenta

353
PTH hypersecretion triggered by a GABA B1 and Ca 2+-sensing receptor heterocomplex in hyperparathyroidism

Wenhan Chang, Chia-Ling Tu, Frederic G. Jean-Alphonse, Amanda Herberger, Zhiqiang Cheng, Jenna Hwong, Hanson Ho, Alfred Li, Dawei Wang, Hongda Liu, Alex D. White, Insoo Suh, Wen Shen, Quan-Yang Duh, Elham Khanafshar, Dolores M. Shoback, Kunhong Xiao & Jean-Pierre Vilardaga

Nature Metabolism (Nature) USA, 09 March 2020

Endocrinology

Key words: Calcium and vitamin D, Homeostasis, Mechanisms of disease, Parathyroid diseases

Organism: Mouse

Tissue: Thyroid

354
Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement

AH Liao, KH Lin, HC Chuang, CH Tsai, YC Lin, CH Wang, CP Shih, HL Liu

Scientific Reports (Nature) Taiwan, 09 March 2020

Tissue Engineering

Key words: Biophysics, Medical research

Organism: Mouse

Tissue: Skin

355
Surface functionalization of pegylated gold nanoparticles with antioxidants suppresses nanoparticle-induced oxidative stress and neurotoxicity

X Zhang, XL Guo, X Kang, H Yang, W Guo, L Guan, H Wu, L Du

Chemical Research in Toxicology (ACS Publications) China, 05 March 2020

Toxicology

Key words: pegylation, gold nanoparticle, neurotoxicity, drug delivery

Organism: Mouse

Tissue: Brain

356
Topography Mediated Fibroblast Cell Migration is Influenced by Direction, Wavelength, and Amplitude

L Ge, L Yang, R Bron, JK Burgess, P van Rijn

ACS Applied Bio Materials (ACS Publications) , 04 March 2020

Biological Materials

Key words: topography, gradient, cell migration, biointerface, wound healing

Organism: Human

Cell Line: Fibroblasts

357
Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR-AKT-mTOR signaling

KY Lee, PW Shueng, CM Chou, BX Lin, MH Lin, DY Kuo, IL Tsai, SM Wu, CW Lin

Cancer Science (Wiley) Taiwan, 04 March 2020

Oncology

Key words: CD109, EGFR, lung cancer, metastasis, mTOR

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

358
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure

Michelle L. Cook Sangar, Emily J. Girard, Gene Hopping, Chunfeng Yin, Fiona Pakiam, Mi-Youn Brusniak, Elizabeth Nguyen, Raymond Ruff, Mesfin M. Gewe, Kelly Byrnes-Blake, Natalie W. Nairn, Dennis M. Miller, Christopher Mehlin, Andrew D. Strand, Andrew J. Mhyre, Colin E. Correnti, Roland K. Strong, Julian A. Simon, James M. Olson

Science Translational Medicine (AAAS) USA, 04 March 2020

Endocrinology

Organism: Human

Tissue: Cartilage

359
Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma

K Alikhanyan, Y Chen, S Kraut, R Sotillo

Immunity, Inflammation and Disease (Wiley) Germany, 03 March 2020

Immunology, Oncology

Key words: alveolar macrophages, clodronate liposomes, EGFR mutation, interstitial macrophages, lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

360
Artificial intelligence as the next step towards precision pathology

B Acs, M Rantalainen, J Hartman

Journal of Internal Medicine (Wiley) Sweden, 03 March 2020

Medical Imaging

Key words: artificial intelligence, deep learning, digital image analysis, digital pathology, machine learning, pathology

361
Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes

LY Chou, CH Chen, YH Lin, SC Chuang, HC Chou, SY Lin, YC Fu, JK Chang, ML Ho, CZ Wang

The FASEB Journal (FASEB) Taiwan, 03 March 2020

Osteology

Key words: chondrocytes, DDR1, discoidin domain receptor 1, endochondral ossification, skeletal development

Organism: Mouse

Tissue: Bone

362
Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Carmen Rapp, Steffen Dettling, Fang Liu, Anna Theresa Ull, Rolf Warta, Christine Jungk, Saskia Roesch, Andreas Mock, Felix Sahm, Melissa Schmidt, Gerhard Jungwirth, Klaus Zweckberger, Katrin Lamszus, Konstaninos Gousias, Almuth F. Kessler, Niels Grabe, Mario Loehr, Ralf Ketter, Steffi Urbschat, Christian Senft, Manfred Westphal, Amir Abdollahi, Juergen Debus, Andreas von Deimling, Andreas Unterberg, Matthias Simon and Christel C. Herold-Mende

Clinical Cancer Research (AACR) Germany, 02 March 2020

Oncology

Key words: Clinically aggressive meningioma, T-cell infiltration, primary and recurrent tumors TILs, PD-1

Organism: Human

Tissue: Brain

Pathological State: Cancer

363
The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray

ES Gruber, G Oberhuber, D Pils, T Stork, K Sinn, S Gruber, R Nica, D Kolmer, SD Turner, M Schlederer, J Widder, W Doerr, B Teleky, L Kenner

Cancers (MDPI) Austria, 29 February 2020

Oncology

Key words: Irradiated rectal cancer, Immunoscore, virtual microscopy, digital pathology, tissue microarray (TMA)

Organism: Human

Tissue: Colon

Pathological State: Cancer

364
Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats

YJ Wu, ME Chien, CH Huang, CC Chiang, CC Lin, CW Huang, DM Durand, KS Hsu

Experimental Neurology (Elsevier) Taiwan, USA, 29 February 2020

Neuroscience

Key words: Status epilepticus, Seizure, Electroencephalography, Mossy fiber sproutin, gBrain-derived neurotrophic factor, Transcranial direct current stimulation

Organism: Rat

Tissue: Brain

Pathological State: Seizures

365
Dermal fillers do not induce upregulation of NLRP3 inflammasomes or expression of inflammatory cytokines in granulomas

Markus Reinholz, Benjamin M. Clanner‐Engelshofen, Markus V. Heppt, Enklajd Marsela, Yoshio Kawakami, Luitgard G. Wiest, Lars E. French, Wilhelm Stolz, Gerd G. Gauglitz

Journal of Cosmetic Dermatology (Wiley) Germany, Japan, 28 February 2020

Dermatology

Key words: Caspase, Fillers, Granulomas, Inflammasome, Interleukins

Organism: Human

Tissue: Skin

366
A transcriptionally distinct CXCL13+ CD103+ CD8+ T-cell population is associated with B-cell recruitment and neoantigen load in human cancer

Hagma H Workel, Joyce M Lubbers, Roland Arnold, Thalina M Prins, Pieter van der Vlies, Kim de Lange, Tjalling Bosse, Inge C Van Gool, Florine A Eggink, Maartje CA Wouters, Fenne L Komdeur, Elisabeth C van der Slikke, Carien L Creutzberg, Arjan Kol, Annechien Plat, Mark Glaire, David N Church, Hans W Nijman and Marco de Bruyn

Cancer immunology Research (AACR) The Netherlands, UK, Canada, 27 February 2020

Oncology

Key words: CXCL13, TGFβ1, tertiary lymphoid structures, CD103+ T cell, immune checkpoint inhibitors

Organism: Human

Pathological State: Cancer

367
Ultrasound-responsive neurotrophic factor-loaded microbubble-liposome complex: Preclinical investigation for Parkinson's disease treatment

CY Lin, YC Lin, CY Huang, SR Wu, CM Chen, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 27 February 2020

Neuroscience

Key words: Ultrasound (US)-targeted microbubble destruction (UTMD), Gene therapy, Blood-brain barrier opening, GDNF, BDNF

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's disease

368
cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer

Y He, M Xiao, H Fu, L Chen, L Qi, D Liu, P Guo, L Chen, Y Luo, H Xiao, N Zhang, H Guo

STEM CELLS (Wiley) China, 26 February 2020

Oncology

Key words: cancer stem cells, CD133, CD24, CD44, cPLA2α, epithelial‐mesenchymal transition

Organism: Human

Tissue: Uterus

Pathological State: Cancer

369
Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway

H Kim, SC Cho, HJ Jeong, HY Lee, MH Jeong, JH Pyun, D Ryu, MS Kim, YS Lee, MS Kim, SC Park, YI Lee, JS Kang

Journal of Cachexia , Sarcopenia and Muscle (Wiley) South Korea, 25 February 2020

Neuroscience

Key words: Exercise mimetic, Hypertrophic response, Indoprofen, Muscle wasting, Muscle weakness, PDK1

Organism: Mouse

Tissue: Muscle

370
Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations

P Chen, S Lou, ZH Huang, Z Wang, QH Shan, Y Wang, Y Yang, X Li, H Gong, Y Jin, Z Zhang, JN Zhou

Neuron (Cell Press) China, 25 February 2020

Neuroscience

Key words: corticotropin-releasing factor neurons, prefrontal cortex, behavioral style selection, social defeat stress

Organism: Mouse

Tissue: Brain

371
Sox2 induces tumorigenesis and angiogenesis of early-stage esophageal squamous cell carcinoma through secretion of Suprabasin

Kiichi Takahashi, Naoki Asano, Akira Imatani, Yutaka Kondo, Masashi Saito, Akio Takeuchi, Xiaoyi Jin, Masahiro Saito, Waku Hatta, Kiyotaka Asanuma, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

Carcinogenesis (Oxford University Press) Japan, 14 February 2020

Oncology

Key words: Sox2, esophageal cancer, Suprabasin, carcinogenesis, angiogenesis

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

372
The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental Study on Porcine Models

Tomáš Andrašina, Josef Jaroš, Tomáš Jůza, Tomáš Rohan, Dalibor Červinka, Michal Crha, Vlastimil Válek & Nahum S. Goldberg

Cardiovascular and Interventional Radiology (Springer) Czech Republic, Israel, 13 February 2020

Cardiology

Key words: Liposomal doxorubicin, Radiofrequency ablation, Irreversible electroporation

Organism: Pig

Tissue: Liver

373
The Impact of Cand1 in Prostate Cancer

Andrea Eigentler, Piotr Tymoszuk, Johanna Zwick, Arndt A. Schmitz, Andreas Pircher, Florian Kocher, Andreas Schlicker, Ralf Lesche, Georg Schäfer, Igor Theurl, Helmut Klocker, Isabel Heidegger

Cancers (MDPI) Austria, Germany, 12 February 2020

Oncology

Key words: Prostate cancer, Cand1, cancer aggressiveness, survival, tumor recurrence, mutation, enzalutamide resistance

Organism: Human

Tissue: Prostate

Pathological State: Cancer

374
Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance

J Dudas, A Ladanyi, J Ingruber, TB Steinbichler, H Riechelmann

Cells (MDPI) Austria, Hungary, 12 February 2020

Oncology

Key words: silibinin, MRX34, PD-L1, NRF2, Krüppel-like factors (KLFs), neurotrophin

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

375
MRI radiomics for early prediction of response to vaccine therapy in a transgenic mouse model of pancreatic ductal adenocarcinoma

A Eresen, J Yang, J Shangguan, Y Li, S Hu, C Sun, Y Velichko, V Yaghmai, AB Benson, Z Zhang

Journal of Translational Medicine (BMC) USA, China, 10 February 2020

Gastroenterology

Key words: Dendritic cell vaccine, Machine learning, Magnetic resonance imaging, Pancreatic ductal adenocarcinoma, Radiomics

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

376
Single cell approaches to address adipose tissue stromal cell heterogeneity

EA Rondini, JG Granneman

Biochemical Journal (Portland Press) USA, 06 February 2020

Endocrinology

Key words: plasticity, single cell RNA-seq, stromal cells, white adipose tissue

377
Acquisition of chromosome instability is a mechanism to evade oncogene addiction

L Salgueiro, C Buccitelli, K Rowald, K Somogyi, S Kandala, JO Korbel, R Sotillo

EMBO Molecular Medicine (EMBO press) Germany, 06 February 2020

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

378
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability

WC Liao, CK Liao, TJ Tseng, YJ Ho, YR Chen, KH Lin, TJ Lai, CT Lan, KC Wie, CH Liu

Oncogenesis (Nature) Taiwan, 04 February 2020

Oncology

Key words: CNS cancer, Growth factor signalling

Organism: Human

Tissue: Brain

Pathological State: Cancer

379
Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy

Y Luo, S Lu, Y Gao, K Yang, D Wu, X Xu, G Sun, X Sun

Aging (Impact Journals) China, 31 January 2020

Cardiology

Key words: atherosclerosis, macrophage polarization, autophagy, Sirt1, Araloside C

Organism: Mouse

Tissue: Heart

Pathological State: Atherosclerosis

380
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I

F Bufalieri, M Caimano, L Lospinoso Severini, I Basili, F Paglia, L Sampirisi, E loricchio, M Petroni, G Canettieri, A Santoro, L D'Angelo, P Infante, L Di Marcotullio

Cancers (MDPI) Italy, 30 January 2020

Oncology

Key words: glioblastoma multiforme (GB), ubiquitylation, E3-ligase, MEX3A, RIG-I

Organism: Human

Pathological State: Cancer

Cell Line: glioblastoma A-172 cells

381
Unidirectional rotating molecular motors dynamically interact with adsorbed proteins to direct the fate of mesenchymal stem cells

Q Zhou, J Chen, Y Luan, PA Vainikka, S Thallmair, SJ Marrink, BL Fering, P van Rijn

Science Advances (AAAS) China, The Netherlands, 29 January 2020

Biological Materials

Organism: Human

Cell Line: hBM-MSCs Cells

382
Cytotoxic CD4+ T lymphocytes may induce epithelial cell apoptosis in systemic sclerosis

Takashi Maehara, Naoki Kaneko, Cory Adam Perugino, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S. Mahajan, Hang Liu, Samuel J.H. Murphy, Musie Ghebremichael, David A. Fox, Aimee S. Payne, Robert Lafyatis, John H. Stone, Dinesh Khanna, and Shiv Pillai

Journal of Clinical Investigation (American Society of Clinical Investigation) USA, Japan, The Netherlands, Canada, China, 28 January 2020

Immunology

Organism: Human

Tissue: Skin

383
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas

J He, Z Huang, M He, J Liao, Q Zhang, S Wang, L Xie, L Ouyang, HP Koeffler, D Yin, A Liu

Molecular Cancer (BMC) China, USA, 28 January 2020

Oncology

Key words: Circ-MAPK4, P38/MAPK signaling pathway, MiR-125a-3p, Gliomas, Apoptosis

Organism: Mouse

Tissue: Xenograft Tumor, Brain

Pathological State: Cancer

384
Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice

N Ran, X Gao, X Dong, J Li, C Lin, M Geng, HF Yin

Biomaterials (Elsevier) China, 25 January 2020

Biological Materials

Key words: Exosome, Duchenne muscular dystrophy, Myostatin, Propeptide

Organism: Rat

Tissue: Muscle, Liver, Kidney

385
The Establishment of Esophageal Precancerous Lesion Model by Using p53 Conditional Knockout Mouse in Esophageal Epithelium

L Zhu, Y Xu, X Chen, J Qin, T Niu, Y Zhu, Y Jiang, S Zhao, K Liu, J Lu, G Jin, J Ma

BioMed Research International (Hindawi Publishing Corporation) China, 25 January 2020

Oncology

Organism: Mouse

Tissue: Esophagus

386
Surfactant expression defines an inflamed subtype of lung adenocarcinoma brain metastases that correlates with prolonged survival

Kolja Pocha, Andreas Mock, Carmen Rapp, Steffen Dettling, Rolf Warta, Christoph Geisenberger, Christine Jungk, Leila R Martins, Niels Grabe, David Reuss, Jürgen Debus, Andreas von Deimling, Amir Abdollahi, Andreas Unterberg and Christel C Herold-Mende

Clinical Cancer Research (AACR) Germany, 17 January 2020

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

387
Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation

E Jo, HJ Jang, KE Yang MS Jang, YH Huh, HS Yoo, JS Park, IK Jang, SJ Park

BMC Complementary Medicine and Therapies (BMC) South Korea, 13 January 2020

Oncology

Key words: Apoptosis, TNF-α, TNFR1, NF-κB, C. militaris

Organism: Human

Cell Line: SKOV-3 Cells

388
High Extra-tumoral Mast Cell Counts are Associated with a Higher Risk of Adverse Prostate Cancer Outcomes

HH Sullivan, CM Heaphy, I Kulac, N Cuka, J Lu, JR Barber, AM De Marzo, TL Lotan, CE Joshu, KS Sfanos

Cancer Epidemiology, Biomarkers & Prevention (AACR) USA, 13 January 2020

Oncology

389
Novel titanium-apatite hybrid scaffolds with spongy bone-like micro architecture intended for spinal application: In vitro and in vivo study

MD Vlad, EF Aguado, SG González, IC Ivanov, EV Sindilar, I Poeata, AS Iencean, M Butnaru, ER Avadanei, J Lopez Lopez

Materials Science and Engineering: C (Elsevier) Romania, Spain, 11 January 2020

Biological Materials

Key words: Titanium-apatite hybrid scaffolds, Osteogenic biomimetic porous scaffolds, Hydroxyapatite bioactive matrix, Bone restoration, Spinal fusion, Additive manufacturing

Organism: Human

Cell Line: Osteoblasts

390
Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model

D Muschter, L Fleischhauer, S Taheri, AF Schilling, H Clausen-Schaumann, S Grässel

Bone (Elsevier) Germany, 08 January 2020

Osteology

Key words: Osteoarthritis, Destabilization of the medial meniscus, Substance P, alpha- Calcitonin gene-related peptide, Bone, Cartilage

Organism: Mouse

Tissue: Bone

391
Racial difference in prostate cancer cell telomere lengths in men with higher-grade prostate cancer: a clue to the racial disparity in prostate cancer outcomes

CM Heaphy, CE Joshu, JR Barber, C Davis, R Zarinshenas, AM De Marzo, TL Lotan, KS Sfanos, AK Meeker, EA Platz

Cancer Epidemiology, Biomarkers & Prevention (AACR) USA, 08 January 2020

Oncology

392
Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer

CW Chang, HC Lee, LH Li, JS Chiang Chiau, TE Wang, WH Chuang, MJ Chen, HY Wang, SC Shih, CY Liu, TH Tsai, YJ Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 08 January 2020

Oncology, Microbiology

Key words: FOLFOX, fecal microbiota transplant, intestinal mucositis, apoptosis, gut microbiota

Organism: Mouse

Tissue: Small Intestine

Pathological State: Cancer

393
Impact of the Sensory and Sympathetic Nervous System on Fracture Healing in Ovariectomized Mice

T Niedermair, RH Straub, C Brochhausen, S Grässel

International Journal of Molecular Sciences (MDPI) Germany, 08 January 2020

Neuroscience

Key words: fracture, substance P, alpha-CGRP, sympathectomy, sympathetic nerve fibers, ovariectomy, sensory nervous system, bone repair, bone remodeling

Organism: Mouse

Tissue: Bone

394
Efficient Labeling Of Mesenchymal Stem Cells For High Sensitivity Long-Term MRI Monitoring In Live Mice Brains

AAA Ali, RA Shahror, KY Chen

International Journal of Nanomedicine (Dove Press) Taiwan, 08 January 2020

Nanomedicine

Key words: iron oxide nanoparticles, FGF21, regenerative medicine, tracking of cells, non-invasive imaging modality

Organism: Human

Cell Line: Mesenchymal Stem Cells

395
Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway

D Liu, H Wang, Y Zhang, Z Zhang

Drug Design, Development and Therapy (Dove Press) China, 07 January 2020

Neuroscience

Key words: cerebral ischemia/reperfusion injury, chlorogenic acid, oxidative stress, neuroprotection, NF-E2-related factor 2 pathway

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

396
The MyoD family inhibitor domain-containing protein enhances the chemoresistance of cancer stem cells in the epithelial state by increasing β-catenin activity

CJ Chen, CJ Yang, SF Yang, MS Huang, YP Liu

Oncogene (Nature) Taiwan, 07 January 2020

Oncology

Key words: Non-small lung cancer, Prognostic

Organism: Human

Tissue: Lung

Pathological State: Cancer

397
TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior

CH Chu, JS Chen, PC Chuang, CH Su, ZL Chan, ZJ Zang, ZT Chiang, PW Gean, HS Sun

The FASEB Journal (Wiley) Taiwan, 07 January 2020

Neuroscience

Key words: guanine nucleotide exchange factor (GEF), hyperlocomotion, neuroplasticity, serotonergic fiber, serotonin (5‐HT), TIAM2

Organism: Mouse

Tissue: Brain

398
Microvascular Disease in Chronic Thromboembolic Pulmonary Hypertension: Hemodynamic Phenotyping and Histomorphometric Assessment

Christian Gerges, Mario Gerges, Richard Friewald, Pierre Fesler, Peter Dorfmüller, Smriti Sharma, Kristof Karlocai, Nika Skoro-Sajer, Johannes Jakowitsch, Bernhard Moser, Shahrokh Taghavi, Walter Klepetko, Irene M. Lang

Circulation (American Heart Association) Austria, Germany, France, Hungary, 03 January 2020

Cardiology

Key words: chronic thromboembolic pulmonary hypertension, upstream resistance, pulmonary vascular resistance, pulmonary arterial compliance, microvascular disease

Organism: Human

Tissue: Lung

399
Anti-BAFF treatment interferes with humoral responses in a model of renal transplantation in rats

L Steines, H Poth, A Schuster, EK Geissler, K Amann, B Banas, T Bergler

Transplantation (Wolters Kluwer) Germany, 01 January 2020

Transplantation Medicine

Organism: Rat

Tissue: Kidney

400
Effects of neoadjuvant FOLFIRONOX and gemcitabine-based chemotherapy on cancer cell survival and death in patients with pancreatic ductal adenocarcinoma

L Xie, L Xia, U Klaiber, M Sachsenmaier, U Hinz, F Bergmann, O Strobel, MW Büchler, JP Neoptolemos, F Fortunato, T Hackert

Oncotarget (Impact Journals) Germany, 31 December 2019

Oncology

Key words: autophagy, cell death, stroma, neoadjuvant therapy, prognosis

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

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Taborstraße 10/2/8
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+43 1 216 11 90
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