Customer Publications (A total of 3040 papers published)

Alkaloids in Uncaria rhynchophylla improves AD pathology by restraining CD4+ T cell-mediated neuroinflammation via inhibition of glycolysis in APP/PS1 mice

Y Kuang, M Zhu, H Gu, Y Tao, H Huang, L Chen

Journal of Ethnopharmacology (Elsevier) China, 03 May 2024

Pharmacology, Immunology

Key words: Alzheimer's disease, Uncaria rhynchophylla, Neuroinflammation, CD4+ T cell, Glycolysis [more]

A non-image-forming visual circuit mediates the innate fear of heights in male mice

W Shang, S Xie, W Feng, Z Li, J Jia, X Cao, Y Shen, J Li, H Shi, Y Gu, SJ Weng, L Lin, Y Pan, XB Yuan

Nature Communications (Nature) China, 03 May 2024

Neuroscience

Key words: Emotion, Neural circuits [more]

A novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer

W Lin, C Chang, J Pan, F Lin, Y Chen, Y Chen, P Wang, W Hong, S Chen, C Lin, Y Kuo, W Chung, H Cheng, M Hsiao, C Yang, P Lu

Cell Death & Disease (Nature) Taiwan, 02 May 2024

Oncology, Genetics

Key words: Breast cancer, Cell invasion [more]

PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis

L Zhang, F Nie, J Zhao, S Li, W Liu, H Guo, P Yang

Journal of Translational Medicine (Springer) China, USA, 30 April 2024

Immunology

Key words: PGRN, Macrophage polarization, TNFR2, Periodontitis, Multiple fluorescence immunohistochemistry [more]

Prognostic and Immunotherapeutic Predictive Value of CAD Gene in Hepatocellular Carcinoma: Integrated Bioinformatics and Experimental Analysis

X Wang, JK Feng, FF Mao, YC Hou, YQ Zhang, LH Liu, Q Wei, JX Sun, C Liu, J Shi, SQ Cheng

Molecular Biotechnology (Springer) China, 29 April 2024

Oncology

Key words: CAD, Hepatocellular carcinoma (HCC), TCGA, Prognosis, Immune therapy [more]

Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism

S Madai, P Kilic, RM Schmidt, C BasOrth, T Korff, M Büttner, G Klinke, G Poschet, HH Marti, R Kunze

Theranostics (Ivyspring) Germany, 29 April 2024

Neuroscience, Metabolism

Key words: HIF, PHD, Roxadustat, ischemic stroke, metabolic reprogramming, aerobic glycolysis [more]

L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury

W Wang, J Zhao, Z Li, X Kang, T Li, N Isaev, E Smirnova, H Shen, L Liu, Y Yu

Biomedicine & Pharmacotherapy (Elsevier) China, Russia, 27 April 2024

Neuroscience, Metabolism

Key words: L-DOPA, GCI/R, Dopamine, Hippocampus, Mitochondria, Respiratory metabolism [more]

Polystyrene microplastics enhance microcystin-LR-induced cardiovascular toxicity and oxidative stress in zebrafish embryos

Y Xiao, L Hu, J Duan, H Che, W Wang, Y Yuan, J Xu, D Chen, S Zhao

Environmental Pollution (Elsevier) China, 26 April 2024

Toxicology, Cardiology

Key words: Microcystin-LR, Polystyrene-MPs/NPs, Cardiovascular toxicity, Calcium, Inflammation, Oxidative stress [more]

Modulation of epithelial-mesenchymal transition by gemcitabine: Targeting ionizing radiation-induced cellular senescence in lung cancer cell

H Zhou, C Li, Y Ren, W Wang, J Zhuang, Y Ren, L Shen, Y Chen

Biochemical Pharmacology (Elsevier) China, 25 April 2024

Oncology

Key words: Epithelial-Mesenchymal Transition, Gemcitabine, Ionizing Radiation, Cellular Senescence, TGFβ/SMAD, Lung Cancer Cell [more]

Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells

W Dai, B Xu, L Ding, Z Zhang, H Yang, T He, L Liu, X Pei, X Fu

Free Radical Biology and Medicine (Elsevier) China, 25 April 2024

Stem Cell Research, Reproductive Medicine

Key words: Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), Premature ovarian insufficiency, Ovarian granulosa cells, Ferritinophagy, Ferroptosis, Nuclear factor erythroid 2-related factor 2 (NRF2) [more]

To develop a prognostic model for neoadjuvant immunochemotherapy efficacy in esophageal squamous cell carcinoma by analyzing the immune microenvironment

Z Yehan, Q Sheng, Y Hong, L Jiayu, H Jun, J Juan, S Min, Y Jiaxin, H Shangzhi, W Yi, W Qifeng, L Xuefeng, H Wenwu, C Xueyan, L Yang, H Zongyao

Frontiers in Immunology (Frontiers) China, 25 April 2024

Oncology, Immunology

Key words: esophageal squamous cell carcinoma (ESCC); neoadjuvant immunochemotherapy (NICT); predictive model; response; tumor immune microenvironment (TIME). [more]

Oncolytic adenovirus in treating malignant ascites: A phase II trial and longitudinal single-cell study

Y Zhang, L Qian, K Chen, S Gu, Z Meng, J Wang, Y Li, P Wang

Molecular Therapy (Cell Press) China, 23 April 2024

Oncology, Virology

Key words: oncolytic virus, malignant ascites, clinical trial, single-cell sequencing [more]

Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity

J Hu, H Xu, T Wu, C Zhang, H Shen, R Dong, Q Hu, Q Xiang, S Chai, G Luo, X Chen, Y Huang, X Zhao, C Peng, X Wu, B Lin, Y Zhang, Y Xu

Journal of Medicinal Chemistry (ACS Publications) China, 22 April 2024

Oncology, Pharmacology

Key words: Assays, Degradation, Inhibitors, Peptides and proteins, Phenyls

Absence of E2f1 Negates Pro-osteogenic Impacts of p21 Absence

P Premnath, T Lun, H Siddiqui, AR Stahl, AA Ardebili, A Olsen, R Krawetz

Calcified Tissue International (Springer) USA, Canada, 21 April 2024

Osteology

Key words: Bone healing, Cell cycle regulation, p21, E2f1, Osteogenesis, Use our pre-submission checklist, Avoid common mistakes on your manuscript [more]

Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model

M Ahmed, LB Tezera, N Herbert, M Chambers, MT Reichmann, K Nargan, H Kloverpris, F Karim, M Hlatshwayo, R Madensein, M Habesh, M Hoque, AJC Steyn, PT Elkington, AJ Leslie

Frontiers in Immunology (Frontiers) South Africa, UK, Denmark, USA, 20 April 2024

Immunology

Key words: CD200 receptor; immune checkpoint; innate immunity; pulmonary infection; tuberculosis [more]

Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization

W Wang, T Li, Y Cheng, F Li, S Qi, M Mao, J Wu, Q Liu, X Zhang, X Li, L Zhang, H Qi, L Yang, K Yang, Z He, S Ding, Z Qin, Y Yang, X Yang, C Luo, Y Guo, C Wang, X Liu, L Zhou, Y Liu, W Kong, J Miao, S Ye, M Luo, L An, L Wang, L Che, Q Niu, Q Ma, X Zhang, Z Zhang, R Hu, H Feng, Y Ping, X Bian, Y Shi

Cancer Cell (Cell Press) China, 18 April 2024

Oncology, Immunology

Key words: glioma, glioblastoma, tumor-associated macrophages, hypoxia, necrosis, vasculature normalization, single-cell transcriptomics, adrenomedullin, spatial transcriptomics, dabrafenib [more]

Efficacy and biomarker analysis of second‐line nab‐paclitaxel plus sintilimab in patients with advanced biliary tract cancer

X Li, N Zhou, Y Yang, Z Lu, H Gou

Cancer Science (Wiley) China, 18 April 2024

Oncology

[more]

ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance

CJ Lee, H Lee, SR Kim, SB Nam, GE Lee, KE Yang, GJ Lee, SH Chun, HC Kang, JY Lee, HS Lee, SJ Cho, YY Cho

Cell Death & Disease (Nature) South Korea, USA, 17 April 2024

Oncology

Key words: Oncogenesis, Ubiquitylation [more]

Spatiotemporal architecture of immune cells and cancer-associated fibroblasts in high-grade serous ovarian carcinoma

AM Xu, M Haro, AE Walts, Y Hu, J John, BY Karlan, A Merchant, S Orsulic

Science Advances (Science) USA, 17 April 2024

Oncology, Immunology

[more]

Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment

NK Horvat, S Chocarro, O Marques, TA Bauer, R Qiu, AJ Diaz-Jimenez, B Helm, Y Chen, S Sawall, R Sparla, L Su, U Klingmüller, M Barz, MW Hentze, R Sotillo, MU Muckenthaler

ACS Nano (ACS Publications) Germany, The Netherlands, 16 April 2024

Oncology

Key words: iron homeostasis, nanoparticle, polymeric miceclle, lung cancer, adjuvant therapy [more]

In vivo SPECT imaging of Tc-99 m radiolabeled exosomes from human umbilical-cord derived mesenchymal stem cells in small animals

YH Chung, YP Ho, SS Farn, WC Tsai, ZX Li, TY Lin, CC Wenig

Biomedical Journal (Elsevier) Taiwan, 16 April 2024

Pharmacology

Key words: Tc-99, USMSC-Evs, SPECT, Biodistribution, Pharmacokinetic analyses [more]

Coronary Microvascular Dysfunction in Acute Cholestasis-Induced Liver Injury

S Billig, M Hein, C Kirchner, D Schumacher, MA Habigt, M Mechelinck, D Fuchs, U Klinge, A Theißen, C Beckers, C Bleilevens, R Kramann, M Uhlig

Biomedicines (MDPI) Germany, The Netherlands, 16 April 2024

Hepatology

Key words: acute cholestatic liver injury; cardiac function; liver–heart axis; rodent model; coronary microvascular dysfunction; myocardial contrast echocardiography; coronary flow velocity reserve [more]

Versatile tissue‐injectable hydrogels capable of the extended hydrolytic release of bioactive protein therapeutics

ES Nealy, SJ Reed, SM Adelmund, BA Badeau, JA Shadish, EJ Girard, K Brasel, FJ Pakiam, AJ Mhyre, JP Price, S Sarkar, V Kalia, CA DeForest, JM Olson

Bioengineering & Translational Medicine (Wiley) USA, 15 April 2024

Biomaterials, Pharmacology

Key words: drug delivery, extended release, hydrogels, immuno-oncology, loco-regional, proteins, sortase [more]

Th17 cells secrete TWEAK to trigger epithelial-mesenchymal transition and promote colorectal cancer liver metastasis

X Liu, X Wang, Q Yang, L Luo, Z Liu, X Ren, K Lei, S Li, Z Xie, G Zheng, Y Zhang, Y Hao, Q Zhou, Y Hou, F Fang, W Song, J Cui, J Ma, W Xie, S Shen, C Tang, S Peng, J Yu, M Kuang, X Song, F Wang, L Xu

Cancer Research (AACR) China, 15 April 2024

Oncology

[more]

Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer

H Hu, H Zhu, W Zhan, B Hao, T Yan, J Zhang, S Wang, X Xu, T Zhang

Inflammation Research (Springer) China, 15 April 2024

Oncology

Key words: Breast cancer, CD24, CD8+ T cell, Tumor immune microenvironment, Immunotherapy [more]

Vaginal Microbiota and Proinflammatory Status in Patients with Polycystic Ovary Syndrome: An Exploratory Study

ME Espinosa, A Melo, M Leon, EV Bautista-Valarezo, F Zambrano, P Uribe, A Bravo, A Taubert, C Hermosilla, V Iturrieta, R Sánchez

Journal of Clinical Medicine (MDPI) Chile, Ecuador, Germany, 15 April 2024

Gynaecology

Key words: polycystic ovary syndrome; phenotypes; vaginal inflammatory reaction; vaginal microbiota; neutrophil extracellular traps (NETs) [more]

Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice

X Wang, Y Jin, C Di, Y Zeng, Y Zhou, Y Chen, Z Pan, Z Li, W Ling

Nutrients (MDPI) China, 14 April 2024

Nutritional science

Key words: dietary silymarin intervention; NAFLD; gut microbiota; fecal microbiome transplantation (FMT); bile acids; secondary bile acids; metabolomics analysis [more]

A novel perspective on di-hexyl phthalate (2-ethylhexyl)-induced reproductive toxicity in females: Lipopolysaccharide synergizes with mono-2-ethylhexyl ester to cause inflammatory apoptosis rather than autophagy in ovarian granulosa cells

B Xu, Z Zhang, H Yang, L Ding, W Dai, L Liu, X Du, X Fu, X Pei

Ecotoxicology and Environmental Safety (Elsevier) China, 13 April 2024

Reproductive Medicine

Key words: Apoptosis; Autophagy; Di-hexyl phthalate (2-ethylhexyl); Inflammation; NF-κB pathway; Ovarian Granulosa Cells [more]

Macrophage-coated tumor cluster aggravates hepatoma invasion and immunotherapy resistance via generating local immune deprivation

J Ning, Y Ye, H Shen, R Zhang, H Li, T Song, R Zhang, P Liu, G Chen, H Wang, F Zang, X Li, J Yu

Cell Reports Medicine (Cell Press) China, 12 April 2024

Oncology, Immunology

Key words: M2BP; T cell exclusion; hepatocellular carcinoma; immune checkpoint inhibitors; immunological evasion; macrophages coated tumor cluster; tumor-associated macrophages [more]

Combined therapy of dabrafenib and an anti-HER2 antibody–drug conjugate for advanced BRAF-mutant melanoma

W Li, C Zheng, X Xu, Y Xia, K Zhang, A Huang, X Zhang, Y Zheng, G Chen, S Zhang

Cellular &Molecular Biology Letters (Springer) China, 10 April 2024

Oncology, Dermatology

Key words: HER2, RC48, Antibody drug conjugate, Dabrafenib, Synergetic effect, Melanoma [more]

Identification of neutrophils and eosinophils in upper airway mucosa with immunofluorescence multiplex image cytometry

AI Giotakis, J Dudas, R Glueckert, E Buechel, H Riechelmann

Histochemistry and Cell Biology (Springer) Austria, 10 April 2024

Immunology, Bioimaging

Key words: Image cytometry, Fluorescent antibody technique, Sinusitis, Leukocytes, Neutrophils, Eosinophils [more]

The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation

AR Murphy, H Asif, H Cingoz, FA Gourronc, JA Ankrum, AJ Klingelhutz, JJ Kim

The Journal of Clinical Endocrinology & Metabolism (Oxford Academic) USA, 10 April 2024

Physiology

Key words: endometrium, obesity, adiposity, metallothionein, progesterone [more]

Prognostic value of CD8+T cells related genes and exhaustion regulation of Notch signaling pathway in hepatocellular carcinoma

Q Pu, L Yu, X Liu, H Yan, Y Xie, X Cai, Y Wu, J Du, Z Yang

Frontiers in Immunology (Frontiers) China, 08 April 2024

Oncology

Key words: hepatocellular carcinoma, CD8+T cells exhaustion, risk scoring, prognosis, Notch signaling pathway [more]

MCP-1 controls IL-17-promoted monocyte migration and M1 polarization in osteoarthritis

SL Hsieh, SY Yang, CY Lin, XY He, CH Tsai, YC Fong, YS Lo, CH Tang

International Immunopharmacology (Elsevier) Taiwan, 08 April 2024

Osteology, Immunology

Key words: IL-17; M1 polarization; MCP-1; Monocyte; Osteoarthritis. [more]

Alkali injury–induced pathological lymphangiogenesis in the iris facilitates the infiltration of T cells and ocular inflammation

Z Liu, K Liu, S Shi, X Chen, X Gu, W Wang, K Mao, R Yibulayi, W Wu, L Zeng, W Zhou, X Lin, F Zhang, B Lou

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 08 April 2024

Immunology, Ophthalmology

Key words: Immunology; Lymph; Ophthalmology; Retinopathy; T cells. [more]

Continuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains

S Feng, T Zhang, Z He, W Zhang, Y Chen, C Yue, N Jing

Cell Regeneration (Springer) China, 07 April 2024

Neuroscience

Key words: Cell transplantation; Human induced neural stem/progenitor cells (iNPCs); Immune response; Non-human primate brain; Xenograft [more]

Integrated analysis of scRNA-seq and bulk RNA-seq reveals that GPRC5A is an important prognostic gene in pancreatic cancer and is associated with B-cell Infiltration in pancreatic cancer

C Dong, H Ma, N Mi, W Fu, J Yi, L Gao, H Wang, Y Ren, Y Lin, F Han, Z Chen, W Zhou

Frontiers in Oncology (Frontiers) China, 03 April 2024

Oncology

Key words: pancreatic cancer, single-cell, immune infiltration, B cell, Gprc5a [more]

A potential bivalent mRNA vaccine candidate protects against both RSV and SARS-CoV-2 infections

N Wu, J Zhang, Y Shen, X Zhang, J Zhou, Y Wu, E Li, X Meng, X Chuai, S Chiu, Y Wang

Molecular Therapy (Cell Press) China, 03 April 2024

Virology

Key words: antigen competition; bivalent vaccine; lipid nanoparticle; mRNA; respiratory infectious disease; respiratory syncytial virus; severe acute respiratory syndrome coronavirus 2. [more]

Shenyu ningshen tablet reduced neuronal damage in the hippocampus of chronic restraint stress model rat by inhibiting A1-reactive astrocytes

Y Wang, S Li, M Chen, M Zeng, L Zhou, R Yao, B Pang, Y Xu, S Cao, S Guo, X Cui

Heliyon (Cell Press) China, 02 April 2024

Neuroscience

Key words: A1 astrocyte; CRS rat model; Depression; Neuron; SYNS tablet [more]

Abrus cantoniensis Hance alleviates APAP-triggered acute liver damage via inhibiting the MAPK and NF-κB signaling pathways in mice

C Zhang, H Gu, C Tu, Y Yang, D Miao, L Chen

Journal of Functional Foods (Elsevier) China, 02 April 2024

Nutritional science

Key words: Abrus cantoniensis Hance, Hepatoprotective, APAP, Oxidative stress, MAPK, NF-κB [more]

A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response

H Yang, X Wu, X Li, W Zang, Z Zhou, Y Zhou, W Cui, Y Kou, L Wang, A Hu, L Wu, Z Yin, Q Chen, Y Chen, Z Huang, Y Wang, B Gu

Nature Communications (Nature) China, 02 April 2024

Immunology

Key words: Antimicrobal responses, Bacterial host response, Interleukins, Parasite host response, T-helper 1 cells [more]

Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells

C Bangert, N Alkon, S Chennareddy, T Arnoldner, JP Levine, M Pilz, MA Medjimorec, J Ruggiero, ER Cohenour, C Jonak, W Damsky, J Griss, PM Brunner

Nature Communications (Nature) Austria, USA, 02 April 2024

Dermatology

Key words: Adaptive immunity, Gene regulation in immune cells, Interleukins, Mucosal immunology, Translational research [more]

Modified Goldner Trichrome for Non-decalcified Mineralized Tissue Plastinated and Embedded in Resin

C Panes, N Ponce, NE Ottone, I ValdiviaGandur, V Beltrán, B Vásquez

International Journal of Morphology (Chilean Society of Anatomy) Chile, 01 April 2024

Histology, Tissue Engineering

Key words: Trichrome staining; Plastic resins; Hard Tissue histology. [more]

Gut microbiota-bile acid crosstalk and metabolic fatty liver in spotted seabass (Lateolabrax maculatus): The role of a cholesterol, taurine and glycine supplement

T Song, X Liang, H Wang, M Xue, J Wang

Animal Nutrition (Elsevier) China, 30 March 2024

Nutritional science

Key words: Cholesterol-taurine-glycine supplement, Plant-based diets, Fatty liver, Gut microbiota–bile acid crosstalk, Lipid metabolism [more]

Anti-osteoporotic effects of Yi Mai Jian on bone metabolism of ovariectomized rats

B Shi, CC Lin, CJ Lee, DS Ning, CC Lin, HW Zhao, CS Yang, SX Deng, YJ Chiu, CC Wang

Frontiers in Pharmacology (Frontiers) China, Taiwan, 28 March 2024

Pharmacology

Key words: anti-osteoporotic effects, Eucommiae Folium, Astragali Radix, Ligustri Lucidi Fructus, Elaeagnus Fructus, Yi Mai Jian herbal formula [more]

Modular Satellite Nanoparticles for Remedying Primary and Secondary Injury in Cerebral Ischemia‐Reperfusion

H Zhou, Y Wu, M Li, Q Liang, W Dong, Q Li, Y Wang

Advanced Functional Materials (Wiley) China, 27 March 2024

Nanomedicine, Neuroscience

[more]

DUSP3 modulates IRES‐dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus

PYM Ferruzo, VK Boell, LC Russo, CC Oliveira, FL Forti

Biology of the Cell (Wiley) Brazil, 27 March 2024

Molecular Biology

Key words: DUSP3, HNRNPC, genome integrity, mRNA translation, protein synthesis, phosphoryla-tion/dephosphorylation

Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys

PB Rupert, M Buerger, EJ Girard, M Frutoso, D Parrilla, K Ng, T Gooley, V Groh, RK Strong

Heliyon (Cell Press) USA, 27 March 2024

Immunology

Key words: Engineered biologic immunotherapeutics; NKG2D; Natural killer cell receptors; X-ray crystallography [more]

Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration

JY Ding, X Yan, RJ Zhang, HQ Zhang, L Kang, CY Jia, XY Liu, CL Shen

European Journal of Medical Research (Springer) China, 25 March 2024

Osteology

Key words: Intervertebral disc degeneration (IVDD), Cartilage oligomeric matrix protein (COMP), A disintegrin and metalloproteinases with thrombospondin motifs7 (ADAMTS7), Biomarkers, Early diagnosis [more]

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

K Baltgalvis, K Lamb, K Symons, C Wu, M Hoffman, A Snead, X Song, T Glaza, S Kikuchi, J Green, D Rogness, B Lam, M RodriguezAguirre, D Woody, C Eissler, S Rodiles, S Negron, S Bernard, E Tran, J Pollock, A Tabatabaei, V Contreras, H Williams, M Pastuszka, J Sigler, P Pettazzoni, M Rudolph, M Classen, D Brugger, C Claiborne, J Plancher, I Cuartas, J Seoane, L Burgess, R Abraham, D Weinstein, G Simon, M Patricelli, T Kinsella

Nature (Nature) USA, Switzerland, Spain, 24 March 2024

Pharmacology, Molecular Biology

Key words: Cancer, Proteomics [more]

Bioactive peptide relieves glucocorticoid-induced osteoporosis by giant macrocyclic encapsulation

Y Shang, Q Zhu, J Ding, L Zhao, F Zhang, J Lu, Y Feng, J Wang, Z Liu, M Kuang, C Li

Journal of Controlled Release (Elsevier) China, 23 March 2024

Pharmacology

Key words: Host-guest complexation; Macrocycles; Peptide; Supramolecular biomedical materials. [more]

Effects of chronic Cr and Ni co-exposure on liver inflammation and autophagy in mice by regulating the TLR4/mTOR pathway

X Cao, S Zheng, Y Zeng, Y Shi, J Du, C Huang, Y Shen, P Liu, X Guo, X Gao

Science of The Total Environment (Elsevier) China, 22 March 2024

Toxicology

Key words: Chromium; Liver toxic effect; Mice; Nickel; TLR4/mTOR pathway. [more]

Anti-CD36 monoclonal antibody can sensitize the neoadjuvant chemotherapy response in PDAC by eliminating the senescent tertiary lymphatic structure

J Yan, T Zhou, C Yang, Y Xie, J Yu, J Hao

Cancer Research (AACR) China, 22 March 2024

Oncology, Pharmacology

Tissue-resident cytotoxic T cell infiltration predicts metachronous colorectal cancer metastasis

R Cohen, T Lee-Pullen, T Miller, S Pirasteh, C Platell, K Meehan, K Fuller, M McCoy

Cancer Research (AACR) Australia, 22 March 2024

Oncology, Immunology

A Mechanistic and Preclinical Assessment of BioRestore Bioactive Glass as a Synthetic Bone Graft Extender and Substitute for Osteoinduction and Spine Fusion

EJ Fred, S Minardi, AM Goodwin, TS Nandurkar, MA Plantz, JG Lyons, JT Paul, JP Foley, AJ Wintring, AA Furman, S Jeong, C Yun, SR Stock, WK Hsu, EL Hsu

Clinical Spine Surgery (Lippincott Williams & Wilkins) USA, 22 March 2024

Osteology

Key words: spinal fusion, bioactive glass, bone graft extender, bone graft substitute, iliac crest bone graft, osteoinductivity [more]

Panax notoginseng saponins improve oral submucous fibrosis by inhabiting the Wnt/β-catenin signal pathway

L Hu, J He, T Zhang, S Pan, H Zou, K Lian, J Guo, T Qun

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology (Elsevier) China, 22 March 2024

Pharmacology

[more]

Rational evolution for altering the ligand preference of estrogen receptor alpha

R Eerlings, P Gupta, XY Lee, T Nguyen, S El Kharraz, F Handle, E Smeets, L Moris, W Devlies, B Vandewinkel, I Thiry, D Tien Ta, A Gorkovskiy, K Voordeckers, E Henckaerts, VB Pinheiro, F Claessens, KJ Verstrepen

Protein Science (Wiley) Belgium, 21 March 2024

Endocrinology

Key words: directed evolution, estrogen receptor, nuclear receptors, Saccharomyces cerevisiae, synthetic biology, tamoxifen [more]

PGR-KITLG signaling drives a tumor-mast cell regulatory feedback to modulate apoptosis of breast cancer cells

Z Yang, H Chen, S Yin, H Mo, F Chai, P Luo, Y Li, L Ma, Z Yi, Y Sun, Y Chen, J Wu, W Wang, T Yin, J Zhu, C Shi, F Zhang

Cancer Letters (Elsevier) China, 20 March 2024

Oncology

Key words: Apoptosis; Breast cancer; GRN; Mast cells; PGR-KITLG signaling. [more]

A subpopulation of luminal progenitors secretes pleiotrophin to promote angiogenesis and metastasis in inflammatory breast cancer

M Zhang, K Zhou, Z Wang, T Liu, LE Stevens, F Lynce, WY Chen, S Peng, Y Xie, D Zhai, Q Chen, Y Shi, H Shi, Z Yuan, XL 0, J Xu, Z Cai, J Guo, N Shao, Y Lin

Cancer Research (AACR) China, USA, 20 March 2024

Oncology

Key words: Inflammatory breast cancer; PTN; Luminal progenitor cell; Angiogenesis; Metastasis [more]

Inhibition of phospholipase D promotes neurological function recovery and reduces neuroinflammation after spinal cord injury in mice

H Ke, F Bai, Z Li, Y Zhu, C Zhang, Y Li, Z Talifu, Y Pan, W Liu, X Xu, F Gao, D Yang, L Du, Y Yu, J Li

Frontiers in Cellular Neuroscience (Frontiers) China, 20 March 2024

Neuroscience

Key words: neuroinflammation; phospholipase D; protein microarray analysis; spinal cord injury; transcriptome sequencing analysis [more]

Aerobic Exercise Modulates Proteomic Profiles in Gastrocnemius Muscle of db/db Mice, Ameliorating Sarcopenia

YC Huang, MR Sanotra, CC Huang, YJ Hsu, CC Liao

Life (MDPI) Taiwan, 20 March 2024

Endocrinology

Key words: aerobic exercise; db/db mice; ECM remodeling; gastrocnemius muscle; metabolic pathways; muscle regeneration; proteomic profiling; T2DM-induced sarcopenia [more]

Metabolic mechanism and pharmacological study of albendazole in secondary hepatic alveolar echinococcosis (HAE) model rats

C Li, Y Zhang, M Pang, Y Zhang, C Hu, H Fan

Antimicrobial Agents and Chemotherapy (American Society for Microbiology) China, 19 March 2024

Parasitology

Key words: albendazole; alveolar echinococcosis; hepatic drug-metabolizing enzyme. [more]

Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome

AJ Diaz-Jimenez, M Ramos, B Helm, S Chocarro, DL Frey, S Agrawal, K Somogyi, U Klingmüller, J Lu, R Sotillo

Drug Resistance Updates (Elsevier) Germany, 19 March 2024

Oncology

Key words: ALK, Lung Cancer, SRC, Resistance, Targeted therapy [more]

Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is suppressed by hsa-miR-200b-3p

J Shi, F Ding, D Dai, X Song, X Wu, D Yan, X Han, G Tao, W Dai

Scientific Reports (Nature) China, 19 March 2024

Oncology

Key words: Cancer. Cancer prevention, Cancer therapy, Cell growth, Cell proliferation, Gastrointestinal cancer [more]

Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer

NCW Ho, JYY Yap, Z Zhao, Y Wang, K Fernando, CH Li, XL Kwang, HS Quah, C Arcinas, NG Iyer, ELS Fong

Advanced Science (Wiley) Singapore, 17 March 2024

Oncology

Key words: CAF heterogeneity; cancer-associated fibroblasts; hydrogel; inflammatory CAF; myofibroblastic CAF [more]

Computer-assisted image analysis of preexisting histological patterns of the cephalic vein to predict wrist arteriovenous fistula non-maturation

JW Chen, M Ting, PY Chang, CJ Jung, CH Chang, SY Fang, LW Liu, KJ Yang, SH Yu, YS Chen, NH Chi, RB Hsu, CH Wang, IH Wu, HY Yu, CY Chan

Journal of the Formosan Medical Association (Elsevier) Taiwan, 16 March 2024

Medical Image Analysis

Key words: Arteriovenous fistula; Computer-assisted image interpretation; Histological technique; Vascular smooth muscle [more]

PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma

G Shu, M Chen, W Liao, L Fu, M Lin, C Gui, J Cen, J Lu, Z Chen, J Wei, W Chen, Y Wang, J Zhu, T Zhao, X Liu, J Jing, GC Liu, Y Pan, J Luo, J Zhang

Cancer Research (AACR) China, 15 March 2024

Oncology

[more]

Targeting ESE3/EHF with Nifurtimox inhibits CXCR2+ neutrophil infiltration and overcomes pancreatic cancer resistance to chemotherapy and immunotherapy

Y Xie, T Zhou, X Li, K Zhao, W Bai, X Hou, Z Liu, B Ni, Z Zhang, J Yan, Y Wang, W Jiang, H Wang, A Chang, S Gao, T Zhao, S Yang, C Huang, J Liu, J Hao

Gastroenterology (Elsevier) China, USA, 15 March 2024

Oncology, Pharmacology

Key words: CXCL1; CXCR2(+) Neutrophils; EHF; Nifurtimox; Pancreatic Cancer. [more]

YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia

Z Liu, S Li, S Chen, J Sheng, Z Li, T Lv, W Yu, Y Fan, J Wang, W Liu, S Hu, J Jin

Iscience (Cell Press) China, 15 March 2024

Urology

Key words: Biochemistry; Cell biology; Molecular biology; Prostate disease [more]

Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iPSNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice

YZ Wang, T Perez-Rosello, SN Smukowski, DJ Surmeier, JN Savas

Molecular Psychiatry (Nature) USA, 14 March 2024

Neuroscience

Key words: Biological techniques, Neuroscience [more]

Nuinsseg: a fully annotated dataset for nuclei instance segmentation in h&e-stained histological images

A Mahbod, C Polak, K Feldmann, R Khan, K Gelles, G Dorffner, R Woitek, S Hatamikia, I Ellinger

Scientific Data (Nature) Austria, 14 March 2024

Medical Image Analysis, Machine Learning

Key words: Computational moderls, Data acquisition, Data processing, Super-resolution microscopy [more]

Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

ZY Li, YQ Mao, Q Hua, YH Sun, HY Wang, XG Ye, JX Hu, YJ Wang, M Jiang

World Journal of Gastroenterology (Baishideng Publishing Group) China, 14 March 2024

Gastroenterology

Key words: Diarrhea-predominant irritable bowel syndrome, Serotonin receptor 2B, Transient receptor potential vanilloid type-1, Visceral hypersensitivity, Abdominal pain [more]

Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection

H Liu, Y Zhang, M Yip, L Ren, J Liang, X Chen, N Liu, A Du, J Wang, H Chang, H Oh, C Zhou, R Xing, M Xu, P Guo, D Gessler, J Xie, PWL Tai, G Gao, D Wang

Molecular Therapy Methods & Clinical Development (Cell Press) USA, 13 March 2024

Pharmacology

Key words: biomanufacturing; plasmid backbone; potency; rAAV; triple transfection [more]

Cytomorphological disparities in invasive breast cancer cells following neoadjuvant endocrine therapy and chemotherapy

H Hoshina, T Sakatani, Y Kawamoto, R Ohashi, H Takei

Pathobiology (Karger) Japan, 12 March 2024

Oncology

Key words: Pathological response, Morphological change, Neoadjuvant endocrine therapy, Microtubule depolymerization, Kinesin motor proteins (KIF) 2A [more]

Disorganized adrenocortical zonational structure in COVID-19 patients: Implications of critical illness duration

TZ Wen, WJ Fu, SQ Xiao, S Wang, TR Li, XY Chen, HY Chen, J Luo, XW Bian, XH Yao

Pathology -Research and Practice (Elsevier) China, 12 March 2024

Virology

Key words: Adrenal cortex; Areas of cortical zonations; COVID-19; Corticosteroid receptor; Structural disorganization [more]

Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis

S Zhang, Q Chen, M Jin, J Ren, X Sun, Z Zhang, Y Luo, X Sun

Phytomedicine (Elsevier) China, 11 March 2024

Neuroscience

Key words: Notoginsenoside R1, Ischemic stroke, Microbiota-gut-brain axis, TLR4/MyD88/NF-κB signaling pathway, Neuroinflammation, Systemic inflammation [more]

Regulation of the immune cell repertoire in psoriasis patients upon blockade of IL-17a or TNFα

J Tittes, J Brell, P Fritz, C Jonak, G Stary, JM Ressler, S Künig, W Weninger, J Stöckl

Dermatology and Therapy (Springer) Austria, 08 March 2024

Dermatology, Immunology

Key words: Psoriasis, Biologics, Immunology, T cells, Dendritic cells [more]

Cytotoxic response of tumor-infiltrating lymphocytes of head and neck cancer slice cultures under mitochondrial dysfunction

MdC Greier, A Runge, J Dudas, R Hartl, M Santer, D Dejaco, TB Steinbichler, J Federspiel, C Seifarth, M Konschake, S Sprung, S Sopper, A Randhawa, M Mayr, BG Hofauer, H Riechelmann

Frontiers in Oncology (Frontiers) Austria, USA, 07 March 2024

Oncology

Key words: cytotoxic T-cells; head and neck carcinoma; immune response; mitochondrial dysfunction; mitochondrial electron transport chain [more]

DUX4-induced HSATII transcription causes KDM2A/B–PRC1 nuclear foci and impairs DNA damage response

T Arends, H Tsuchida, RO Adeyemi, SJ Tapscott

Journal of Cell Biology (Rockerfeller University Press) USA, 07 March 2024

Molecular Biology

Key words: Chromatin or epigenetics, Development, Disease, RNA biology

Precursor exhausted CD8+T cells in colorectal cancer tissues associated with patient's survival and immunotherapy responsiveness

H Huang, J Ge, Z Fang, S Wu, H Jiang, Y Lang, J Chen, W Xiao, B Xu, Y Liu, L Chen, X Zheng, J Jiang

Frontiers in Immunology (Frontiers) China, 06 March 2024

Oncology

Key words: colorectal cancer; immunotherapy; multi-color immunohistochemistry; multi-omics; precursor exhausted CD8+T cells [more]

Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression

L Tong, X Zheng, T Wang, W Gu, T Shen, W Yuan, S Wang, S Xing, X Liu, C Zhang, C Zhang

Journal of Cellular and Molecular Medicine (Wiley) China, 06 March 2024

Oncology

Key words: autophagy, EMC6, hepatocellular carcinoma, progression, tumorigenesis, UBA52 [more]

Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury

JB Cao, ST Zhu, XS Huang, XY Wang, ML Wu, X Li, FL Liu, L Chen, YT Zheng, JH Wang

Virologica Sinica (Elsevier) China, 06 March 2024

Virology

Key words: SARS-CoV-2, Mast cell (MC), Bronchial epithelial cell, Inflammation, Tracheal injury [more]

Oleic acid induces lipogenesis and NLRP3 inflammasome activation in organotypic mouse meibomian gland and human meibomian gland epithelial cells

R Liu, M Tu, J Xue, B Xiao, J Li, L Liang

Experimental Eye Research (Elsevier) China, 05 March 2024

Ophthalmology

Key words: Oleic acid, Meibomian gland dysfunction, Lipid, NLRP3 inflammasome, AMPK [more]

Construction of an infectious clone for enterovirus A89 and mutagenesis analysis of viral infection and cell binding

J Yan, M Wang, X Li, J Fan, R Yu, M Kang, Y Zhang, J Xu, X Zhang, S Zhang

Microbiology Spectrum (American Society for Microbiology) China, 05 March 2024

Virology

Key words: enterovirus A89; infectious clone; reverse genetics; site mutations; subgenomic replicon [more]

Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression

F Khan, Y Lin, H Ali, L Pang, M Dunterman, WH Hsu, K Frenis, RG Rowe, DA Wainwright, K McCortney, LK Billingham, J Miska, C Horbinski, MS Lesniak, P Chen

Nature Communications (Nature) USA, 05 March 2024

Oncology

Key words: Cancer metabolism, Caner microenvironment, Monocytes and macrophages [more]

Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial-Mesenchymal Transition

L Fang, L Zhang, M Wang, Y He, J Yang, Z Huang, Y Tan, K Fang, J Li, Z Sun, Y Li, Y Tang, W Liang, H Cui, Q Zhu, Z Wu, Y Li, Y Hu, W Chen

Cancer Research (AACR) China, 04 March 2024

Oncology

[more]

FUSeg: The foot ulcer segmentation challenge

C Wang, A Mahbod, I Ellinger, A Galdran, S Gopalakrishnan, J Niezgoda, Z Yu

Information (MDPI) USA, Austria, UK, 01 March 2024

Bioimaging

Key words: semantic segmentation, chronic wounds, foot ulcers, wound segmentation, challenge, benchmark

Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition

YT Huang, YT Hsu, PY Wu, YM Yeh, PC Lin, KF Hsu, MR Shen

Journal of Experimental & Clinical Cancer Research (Springer) Taiwan, 01 March 2024

Oncology

Key words: Cingulin, Rac1, IQGAP1, Epithelial-mesenchymal transition, Cancer-predisposing variant [more]

Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis.

NS Dey, S Senaratne, V Somaratne, NP Madarasinghe, B Seneviratne, S Forrester, MMd Oca, LC Reis, S Moulik, PB Walrad, M Chatterjee, H Goto, R Wickremasinghe, D Lagos, PM Kaye, S Ranasinghe

The Journal of Clinical Investigation (American Society for Clinical Investigation) UK, Sri Lanka, Brazil, India, 01 March 2024

Dermatology

[more]

Nicotinamide phosphoribosyltransferase modulates PD-L1 in bladder cancer and enhances immunotherapeutic sensitivity

KC Chen, T Dhar, CR Chen, ECY Chen, CC Peng

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Taiwan, 29 February 2024

Oncology

Key words: Bladder cancer (BLCA); NAMPT (nicotinamide phosphoribosyltransferase); PD-L1 (programmed death ligand 1); Tumor microenvironment (TME). [more]

Triple‐negative breast cancer survival prediction using artificial intelligence through integrated analysis of tertiary lymphoid structures and tumor budding

X Hou, X Li, Y Han, H Xu, Y Xie, T Zhou, T Xue, X Qian, J Li, HC Wang, J Yan, X Guo, Y Liu, J Liu

Cancer (Wiley) China, 29 February 2024

Oncology

Key words: artificial intelligence, nomogram, tertiary lymphoid structures, triple-negative breast cancer, tumor budding [more]

Inhibition of P2X7R alleviates neuroinflammation and brain edema after traumatic brain injury by suppressing the NF-κB/NLRP3 inflammasome pathway

B Tao, J Pei, H Li, G Yang, X Shi, Z Zhang, H Wang, Z Zheng, Y Liu, J Zhang

Journal of Neurorestoratology (Elsevier) China, 29 February 2024

Neuroscience

Key words: Traumatic brain injury, Neuroinflammation, Brain edema, P2X7R, NF-κB, NLRP3 [more]

Immune microenvironment heterogeneity of concurrent adenocarcinoma and squamous cell carcinoma in multiple primary lung cancers

J Zhang, Y Huang, Y Han, D Dong, Y Cao, X Chen, D Liu, X Cheng, D Sun, H Li, Y Zhang

NPJ Precision Oncology (Nature) China, 29 February 2024

Oncology

Key words: Cnacer genomics, Cancer microenvironment, Non-small-cell lung cancer, Tumour immunology [more]

Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5

L Ding, Y Sun, Y Liang, J Zhang, Z Fu, C Ren, P Li, W Liu, R Xiao, H Wang, Z Zhang, X Yue, C Li, Z Wu, Y Feng, X Liang, C Ma, L Gao

Advanced Science (Wiley) China, 28 February 2024

Endocrinology

Key words: Gαs ubiquitination; Tipe1; deubiquitinase USP5; diabetes; islet β cell [more]

TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis

Y Li, S Luan, C Ruan, W Li, X Zhang, Z Ran, W Bi, Y Tong, L Gao, J Zhao, Y Li, Z He

Biochemical and Biophysical Research Communications (Elsevier) China, 28 February 2024

Neuroscience

Key words: Thyroid-stimulating hormone receptor (TSHR); Memory; Cognitive impairment; Wnt5a; Neurogenesis [more]

Peripheral neural interfaces: Skeletal muscles are hyper-reinnervated according to the axonal capacity of the surgically rewired nerves

V Tereshenko, DC Dotzauer, M Schmoll, L Harnoncourt, GC Rojas, L Gfrerer, KR Eberlin, WG Austen Jr., R Blumer, D Farina, OC Aszmann

Science Advances (Science) USA, Austria, UK, 28 February 2024

Neuroscience

[more]

Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice

J Hu, K He, Y Yang, C Huang, Y Dou, H Wang, G Zhang, J Wang, C Niu, G Bi, L Zhang, S Zhu

Cell Reports (Cell Press) China, 26 February 2024

Neuroscience, Nutritional science

Key words: CP: Microbiology; CP: Neuroscience; amino acid formula; depression; microbiota. [more]

Combined inhibition of HER2 and VEGFR synergistically improves therapeutic efficacy via PI3K-AKT pathway in advanced ovarian cancer

W Li, K Zhang, W Wang, Y Liu, J Huang, M Zheng, L Li, X Zhang, M Xu, G Chen, L Wang, S Zhang

Journal of Experimental & Clinical Cancer Research (Springer) China, 26 February 2024

Oncology

Key words: HER2, VEGFR, Antibody drug conjugate, RC48, Cediranib Maleate, Synergetic effect, Ovarian cancer [more]

Negative impact of ratio of the microvascular area to tumor area on the response to EGFR-TKI in non-small cell lung cancer with an EGFR mutation

M Anai, K Saruwatari, K Imamura, K Fujino, T Jodai, S Sakata, S Iyama, Y Tomita, S Saeki, H Ichiyasu, K Ikeda, M Suzuki, T Sakagami

Journal of Thoracic Disease (AME) Japan, 26 February 2024

Oncology

Key words: Non-small cell lung cancer (NSCLC), epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), microvascular area, microvascular density (MVD) [more]

Use of Atrial Fibrillation Electrograms and T1/T2 Magnetic Resonance Imaging to Define the Progressive Nature of Molecular and Structural Remodeling: A New Paradigm Underlying the Emergence of Persistent Atrial Fibrillation

M Rottmann, S Yoo, A Pfenniger, A Mikhailov, B Benefield, DA Johnson, W Zhang, AK Ghosh, D Kim, R Passman, BP Knight, DC Lee, R Arora

Journal of the American Heart Association (American Heart Association) USA, 23 February 2024

Cardiology

Key words: MRI; arrhythmias; atrial fibrillation; fibrosis; mapping; reactive oxygen species [more]

Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice

Q Wu, Q Ren, X Wang, H Bai, D Tian, G Gao, F Wang, P Yu, YZ Chang

CNS Neuroscience & Therapeutics (Wiley) China, 22 February 2024

Neuroscience

Key words: Per1; aging; circadian rhythm; clock genes; iron [more]

RBM3 Promotes Anti-inflammatory Responses in Microglia and Serves as a Neuroprotective Target of Ischemic Stroke

J Zhao, S Liu, K Li, Y Yang, Y Zhao, X Zhu

Molecular Neurobiology (Springer) China, 22 February 2024

Neuroscience

Key words: Ischemic stroke, Cold-inducible RNA-binding proteins, Small molecule zr17-2, Neuroprotection, Neuroinflammation, Microglia [more]

NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis

CY Lin, KT Lee, YY Lin, CH Tsai, CY Ko, YC Fong, SM Hou, WL Chen, CC Huang, CH Tang

International Immunopharmacology (Elsevier) Taiwan, 21 February 2024

Neuroscience

Key words: NGF; Rheumatoid arthritis; ICAM-1; M1 macrophage; TrkA [more]

Tumor histoculture captures the dynamic interactions between tumor and immune components in response to anti-PD1 in head and neck cancer

NP Basak, K Jaganathan, B Das, O Muthusamy, R M, R Malhotra, A Samal, M Nath, G MS, AP Shankar, P BV, V Pillai, M BV, J C, V K, GS K, S Govindan, S V, Jy, K R, C Bhowal, U Kumar, G K, M Malhotra, S Sankaran

Nature Communications (Nature) India, 21 February 2024

Oncology, Immunology

Key words: Cancer models, Head and neck cancer, Tumour immunology [more]

CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma

S Wei, Y Zhang, BE Kang, W Park, H Guo, S Nam, JS Kang, JH Jeong, Y Jo, D Ryu, Y Jiang, KT Ha

BMB Reports () China, South Korea, 20 February 2024

Oncology

Key words: Clinical biomarker, Cyclin-dependent kinase inhibitor 2, Hepatocellular carcinoma, T cell exhaustion, Tissue microarray

TIMP3/Wnt axis regulates gliosis of Müller glia

JH Hung, PH Tsai, WJF Aala, CC Chen, SH Chiou, TW Wong, KJ Tsai, SM Hsu, LW Wu

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Taiwan, 17 February 2024

Ophthalmology

Key words: Müller cell; Müller glia; Gliosis; Age-related macular degeneration (AMD); Laser-induced choroidal neovascularization (CNV); Proliferative diabetic retinopathy (PDR) [more]

Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model

YC Shyu, TS Huang, HS Chiu, P Sumazin, XY Lin, PC Liao, CC Liou, FC Hsu, JS Lin, CC Hsu, PH Hsu, CC Sun, CT Chen

International Journal of Molecular Science (MDPI) Taiwan, USA, 17 February 2024

Regenerative Medicine

Key words: negative pressure wound therapy (NPWT); dickkopf-related-protein1 (DKK-1); hair follicle stem cells (HFSCs); epidermal cells; inflammatory [more]

CXCR5+TIM-3-PD-1+ stem-like cytotoxic CD8+ T cells: elevated in chronic rhinosinusitis and associated with disease severity

Z Liu, Z Zhao, H Xie, N Lu, J Liu, Q Jiao

Frontiers in Immunology (Frontiers) China, 15 February 2024

Immunology

Key words: chronic rhinosinusitis, PD-1+, CXCR5+, TIM-3-, stem-like CD8+ T cells [more]

INHBA (+) cancer-associated fibroblasts generate an immunosuppressive tumor microenvironment in ovarian cancer

Y Hu, MS Recouvreux, M Haro, E Taylan, BH Taylor-Harding, AE Walts, BY Karlan, S Orsulic

NPJ Precision Oncology (Nature) USA, 15 February 2024

Oncology

Key words: Cell biology, Gynaecological cancer [more]

Quercetin Promotes Apoptosis of Gastric Cancer Cells through the EGFR-ERK Signaling Pathway

, B Zhang, J Zhu, X Wei, R Huang, Y Zhang, Q Jin

Journal of Food Biochemistry (Hindawi) China, 13 February 2024

Oncology

[more]

A Divalent Chikungunya and Zika Nanovaccine with Thermostable Self‐assembly Multivalent Scaffold LS‐SUMO

Q Li, J Zhang, Q Deng, C Liao, J Qian, Z Chen, J Lu

Advanced Healthcare Materials (Wiley) China, 10 February 2024

Virology

[more]

Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner

J Zhao, C Yao, Y Qin, H Zhu, H Guo, B Ji, X Li, N Sun, R Li, Y Wu, K Zheng, Y Pan, T Zhao, J Yang

Cell Death & Disease (Nature) China, 08 February 2024

Oncology

Key words: Cancer immunotherapy, Immunotherapy [more]

Immune checkpoint ligands expressed on mature high endothelial venules predict poor prognosis of NSCLC: have a relationship with CD8+ T lymphocytes infiltration

J Luo, X Shi, Y Liu, J Wang, H Wang, X Yang, Q Sun, Z Hui, F Wie, X Ren, H Zhao

Frontiers in Immunology (Frontiers) China, 08 February 2024

Oncology

Key words: lung cancer, immune checkpoint ligands, high endothelial venules, lymphocytes infiltration, tertiary lymphoid structures [more]

Effect of surface modification on the distribution of magnetic nanorings in hepatocellular carcinoma and immune cells

W Jiao, N Wen, S Wang, G Zhou, Q Lu, Z Su, X Wang, S Hu, Y Xie, N Zhang, X Liu

Journal of Materials Chemistry B (Royal Society of Chemistry) China, 08 February 2024

Oncology, Nanomedicine

Gene therapy corrects the neurological deficits of mice with sialidosis

WL Hwu, K Chang, YH Liu, HC Wang, NC Lee, YH Chien

Gene Therapy (Nature) Taiwan, 07 February 2024

Neuroscience

Key words: Metabolic disorders, Neurological disorders [more]

Assessment of the nano-mechanical properties of healthy and atherosclerotic coronary arteries by atomic force microscopy

F Savvopoulos, MC Keeling, D Carassiti, NA Fogell, MB Patel, J Naser, N Gavara, Rd Silva, R Krams

Journal of the Royal Society Interface (The Royal Society) Uk, Spain, 07 February 2024

Bioimaging

Key words: atomic force microscopy, coronary arteries, atherosclerosis, nano-indentation, collagen microstructure, mechnanical properties [more]

DDAH1 promotes neurogenesis and neural repair in cerebral ischemia

Q Gao, P Ni, Y Wang, P Huo, X Zhang, S Wang, F Xiao, Y Li, W Feng, J Yuan, T Zhang, Q Li, B Fan, Y Kan, Z Li, Y Qi, J Xing, Z Yang, H Cheng, X Gao, X Feng, M Xue, Y Liu, Y Luo, Z Lu, Y Zhao

Acta Pharmaceutica Sinica B (Elsevier) China, 06 February 2024

Neuroscience

Key words: DDAH1, Neurogenesis, Neural repair, ChAT, HIF-1α, Ach, Stroke, ADMA [more]

FSTL1 Accelerates Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration Through TLR4/NF-κB Pathway

X Yan, JY Ding, RJ Zhang, HQ Zhang, L Kang, CY Jia, XY Liu, CL Shen

Inflammation (Springer) China, 06 February 2024

Cell Biology

Key words: FSTL1, Cellular senescence, IVDD, TLR4/NF-κB [more]

Profiling Fibroblast Growth Factor Receptor 3 Expression Based on the Immune Microenvironment in Upper Tract Urothelial Carcinoma

K Shigeta, K Matsumoto, S Kitaoka, M Omura, K Umeda, Y Arita, S Mikami, K Fukumoo, Y Yasimizu, N Tanaka, T Taked, S Morit, T Kosaka, R Mizuno, S Hara, M Oya

European Urology Oncology (Elsevier) Japan, 05 February 2024

Oncology, Urology

Key words: Upper tract urothelial carcinoma, Fibroblast growth factor receptor 3, CD8, CD204, Immune microenvironment [more]

Periostin in Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression by Enhancing Cancer and Stromal Cell Migration

S Miyako, Y Koma, T Nakanishi, S Tsukamoto, K Yamanaka, N Ishihara, Y Azumi, S Urakami, M Shimizu, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki

The American Journal of Pathology (Elsevier) Japan, 05 February 2024

Oncology

[more]

Rapid prototyping of PMMA-based microfluidic spheroid-on-a-chip models using micromilling and vapour-assisted thermal bonding

MAM Ahmed, KM Jurczak, NS Lynn Jr, JPSH Mulder, EMJ Verpoorte, Anika Nagelkerke

Scientific Reports (Nature) The Netherlands, Czech Republic, 03 February 2024

Biological Methods

Key words: Biomedical engineering, Cancer models [more]

Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice

Y Li, C Zhang, Z Li, F Bai, Y Jing, H Ke, S Zhang, Y Yan, Y Yu

Current Issues in Molecular Biolog (MDPI) China, 01 February 2024

Neuroscience

Key words: Spinal cord injury, nicotinamide riboside, NAD+, neuroinflammation, functional recovery [more]

Modified Goldner Trichrome for Non-decalcified Mineralized Tissue Plastinated and Embedded in Resin.

C Panes, N Ponce, NE Ottone, I Valdivia-Gandur, V Beltrán, B Vásquez

International Journal of Morphology (Chilean Society of Anatomy) Chile, 01 February 2024

Biological Methods

Key words: Trichrome staining; Plastic resins; Hard Tissue histology [more]

Urban Particulate Matter Triggers Meibomian Gland Dysfunction

M Tu, R Liu, J Xue, B Xiao, J Li, L Liang

Investigative Ophthalmology & Visual Science (ARVO Journals) China, 01 February 2024

Ophthalmology

[more]

Efficacy and safety of mTOR inhibition in cutaneous sarcoidosis: a single-centre trial

A Redl, K Doberer, L Unterluggauer, L Kleissl, C Krall, C Mayerhofer, B Reininger, V Stary, N Zila, W Weninger, T Weichhart, C Bock, T Krausgruber, G Stary

The Lancet Rheumatology (The Lancet) Austria, 01 February 2024

Pharmacology

[more]

Radiotherapy Resistance of 3D Bioprinted Glioma via ITGA2/P‐AKT Signaling Pathway

D Liu, H Tian, H Li, J Nie, Z Han, G Tang, P Gao, H Cheng, X Dai

Advanced Healtcare Materials (Wiley) China, 30 January 2024

Oncology

Key words: 3D bioprinting, glioma, ITGA2, p-AKT, radiotherapy resistance [more]

Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis

W Chen, B Jin, C Cheng, H Peng, X Zhang, W Tan, R Tang, X Lian, H Diao, N Luo, X Li, J Fan, J Shi, C Yin, J Wang, S Peng, L Yu, J Li, RQ Wu, DM Kuang, GP Shi, Y Zhou, F Wang, X Jiang

Annals of the Rheumatic Diseases (BMJ Journals) China, 30 January 2024

Nephrology

[more]

Neoadjuvant chemotherapy-induced remodeling of human hormonal receptor-positive breast cancer revealed by single-cell RNA sequencing

F Jia, S Sun, J Li, W Wang, H Huang, X Hu, S Pan, W Chen, L Shen, Y Yao, S Zheng, H Chen, W Xia, H Yuan, J Zhou, T Zhang, B Zhang, J Huang

Cancer Letters (Elsevier) China, 30 January 2024

Oncology, Pharmacology

Key words: HR+ breast cancer, Neoadjuvant chemotherapy, Tumor microenvironment, Chemotherapy resistance, Single cell sequencing [more]

Neutralizing IL-16 enhances the efficacy of targeting Aurora-A therapy in colorectal cancer with high lymphocyte infiltration through restoring anti-tumor immunity

SJ Yang, ST Chang, KC Chang, BW Lin, KY Chang, YW Liu, MD Lai, LY Hung

Cell Death & Disease (Nature) Taiwan, 30 January 2024

Oncology, Immunology

Key words: Cancer, Immunology [more]

FLIP (C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress

JD Tischler, H Tsuchida, R Bosire, TT Od, A Park, RO Adeyemi

Nature Communications (Nature) USA, 29 January 2024

Oncology

Key words: Breast Cancer, Homologous recombination, Proteasome, Stalled forks [more]

The Influence of Computed Tomography Contrast Agent on Radiation-Induced Gene Expression and Double-Strand Breaks

S Schüle, F Bunert, C Hackenbroch, M Beer, P Ostheim, S Stewart, M Port, H Scherthan, M Abend

Radiation Research (Radiation Research Society) Germany, 29 January 2024

Radiology, Molecular Biology

New insight into prurigo nodularis: Proadrenomedullin N‐terminal 20 peptide mediates mouse mast cell activation via Mrgprb2

Y Shao, Z Xiao, Y Jin, Y Zhu, Y Shen, T Jin, H Tang, D Wang

Skin Research and Technology (Wiley) China, 29 January 2024

Dermatology, Immunology

Key words: chronic pruritus; mas-related G-protein-coupled receptor X2; mast cells; proadrenomedullin N-terminal 20 peptide; prurigo nodularis [more]

Downregulation of S100A11 promotes T cell infiltration by regulating cancer-associated fibroblasts in prostate cancer

D Han, C Guo, H Cheng, J Lu, Z Hou, X Zhang, Y Luo, B Zhang, W Zhao, P Shang

International Immunopharmacology (Elsevier) China, 28 January 2024

Oncology

Key words: S100A11, CAFs. T cell infiltration, Edafitinib [more]

A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs

C Wang, M Sun, C Shao, L Schlicker, Y Zhuo, Y Harim, T Peng, W Tian, N Stöffler, D Helm, Y Chu, B Fu, X Jin, JP Mallm, M Mall, Y Wu, A Schulze, HK Liu

NPJ Precision Oncology (Nature) China, Germany, 26 January 2024

Oncology, Pharmacology

Key words: Cancer genetics, CNS cancer, Drug screening, Tumour hetereogeneity [more]

Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy

YK Huang, WC Cheng, TT Kuo, JC Yang, YC Wu, HH Wu, CC Lo, CY Hsieh, SC Wong, CH Lu, WL Wu, SJ Liu, YC Li, CC Lin, CN Shen, MC Hung, JT Lin, CC Yeh, YP Sher

Nature Cancer (Nature) Taiwan, 24 January 2024

Oncology

[more]

Salvia miltiorrhiza Bunge extract and Przewalskin ameliorate Bleomycin-induced pulmonary fibrosis by inhibition of apoptosis, oxidative stress and collagen deposition via the TGF-β1 pathway

M Zeng, A Feng, Y Ren, Q Zhang, R Wang, B Zhang, M Liu, P Guo, Y Zhang, J Lyu, X Zheng

Phytomedicine (Elsevier) China, 24 January 2024

Pulmonology

Key words: Przewalskin; Pulmonary fibrosis; SPR ligand fishing; Salvia miltiorrhiza Bunge (Labiatae); Transcriptome sequencing. [more]

Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice

R Driscoll, L Hampton, NA Abraham, JD Larigan, NF Joseph, JCV Hernandez-Vega, S Geisler, FC Yang, M Deninger, DT Tran, N Khatri, BMDC Godinho, GA Kinberger, DR Montagna, WD Hirst, CL Guardado, KE Glajch, HM Arnold, CLB Gallant-Behm, A Weihofen

Scientific Reports (Nature) USA, 24 January 2024

Neuroscience

Key words: Huntington's disease, Pharmacodynamics [more]

Gut ribotoxic stress responses facilitate dyslipidemia via metabolic reprogramming: an environmental health prediction

J Kim, H Jeong, N Ray, KH Kim, Y Moon

Theranostics (Ivyspring) South Korea, 20 January 2024

Gastroenterology

Key words: Ribotoxic stress responses, human inflammatory bowel diseases, dyslipidemia, LDL receptor, deoxynivalenol [more]

Impairment of adenosine signaling disrupts early embryo development: unveiling the underlying mechanisms

T Glaser, P Martins, R Beco, CA Bento, AR Cappellari, SLB Oliveira, CA Merkel, VFS Arnaud-Sampaio, C Lameu, AM Battastini, H Ulrich

Frontiers in Pharmacology (Frontiers) Brazil, 19 January 2024

Pharmacology

Key words: purinergic signaling, ERK1/2, calcium signaling, embryonic stem cells, adenosine, caffeine [more]

IL-6 upregulates expression of LMO4 in psoriatic keratinocytes through activation of the MEK/ERK/NF-κB pathway

Z Tu, W Wei, F Zeng, W Wang, Y Zhang, Y Zhang, F Zhou, C Cai, S Zhang, H Zhou

The American Journal of Pathology (Elsevier) China, 19 January 2024

Dermatology

[more]

Differential pathogenic and molecular features in neurological infection of SARS‐CoV‐2 Omicron BA. 5.2 and BA. 2.75 and Delta

E Wang, QJ Yang, XX Xu, QC Zou, Y Long, G Ma, ZH Deng, JB Zhao, MH Li, J Zeng

Journal of Medical Virology (Wiley) China, 18 January 2024

Virology

Key words: BA.2.75, BA.5.2, Delta, hACE2 knock‐in mice, neurological dysfunction, SARS‐CoV‐2, Spike protein, γ‐secretase [more]

Strain-induced bands of Büngner formation promotes axon growth in 3D tissue-engineered constructs

C Hromada, D Szwarc-Hofbauer, MQ Nguyen, J Tomasch, M Purtscher, D Hercher, AH Teuschl-Woller

Journal of Tissue Engineering (Sage Journals) Austria, 18 January 2024

Neuroscience

[more]

Microbial colony sequencing combined with metabolomics revealed the effects of chronic hexavalent chromium and nickel combined exposure on intestinal inflammation in mice

Y Gu, S Zheng, C Huang, X Cao, P Liu, Y Zhuang, G Li, G Hu, X Gao, X Guo

Science of The Total Environment (Elsevier) China, 18 January 2024

Gastroenterology

Key words: Hexavalent chromium,Nickel, Inflammatory response, Microbiome, Metabolomics [more]

Analysis of organoid and immune cell co-cultures by machine learning-empowered image cytometry

P Stüve, B Nerb, S Harrer, M Wuttke, M Feuerer, H Junger, E Eggenhofer, B Lungu, S Laslau, U Ritter P Stüve, B Nerb, S Harrer, M Wuttke, M Feuerer, H Junger, E Eggenhofer, B Lungu, S Laslau, U Ritter

Frontiers in Medicine (Frontiers Media S.A.) Germany, Romania, 17 January 2024

Medical Image Analysis, Machine Learning

[more]

Spatial and Single-Cell Transcriptomics Reveal a Cancer-Associated Fibroblast Subset in HNSCC That Restricts Infiltration and Antitumor Activity of CD8+ T Cells

C Li, H Guo, P Zhai, M Yan, C Liu, X Wang, C Shi, J Li, T Tong, Z Zhang, H Ma, J Zhang

Cancer Research (AACR) China, 16 January 2024

Oncology

Key words: Lymphocyte biology [more]

Myeloid zfhx3 deficiency protects against hypercapnia-induced suppression of host defense against influenza A virus

SM CasalinoMatsuda, F Chen, F GonzalezGonzalez, H Matsuda, A Nair, H AbdalaValencia, G Budinger, JT Dong, G Beitel, P Sporn

JCI insight (American Society for Clinical Investigation) USA, China, 16 January 2024

Immunology, Virology

Key words: Influenza, Innate immunity, Macrophages [more]

The effector program of human CD8 T cells supports tissue remodeling

M Delacher, L Schmidleithner, M Simon, P Stüve, L Sanderink, A Hotz-Wagenblatt, M Wuttke, K Schambeck, B Ruhland, V Hofmann, S Bittner, U Ritter, A Pant, SS Helbich, M Voss, NA Lemmermann, L Bessiri-Schake, T Bohn, A Eigenberger, AN Menevse, C Gebhard, N Strieder, H Abken, M Rehli, J Huehn, P Beckhove, T Hehlgans, H Junger, EK Geissler, L Prantl, JM Werner, C Schmidl, B Brors, CD Imbusch, M Feuerer

Journal of Experimental Medicine (Rockerfeller University Press) Germany, 16 January 2024

Oncology, Pharmacology

[more]

FMRP regulation of aggrecan mRNA translation controls perineuronal net development

HM Van't Spijker, JD Richter

Journal of Neurochemistry (Wiley) USA, UK, 15 January 2024

Neuroscience

Key words: aggrecan, FMRP, fragile X syndrome, perineuronal net [more]

SHCBP1 Overexpression Aggravates Pancreatitis by Triggering the Loss of Primary Cilia

L Li, H Zhao, Z Li, W Shi, Z Jiao

DNA and Cell Biology (Mary Ann) China, 12 January 2024

Cell Biology

Key words: LPS; SHCBP1; acute pancreatitis; cerulein; primary cilia. [more]

Circadian misalignment impairs oligodendrocyte myelination via Bmal1 overexpression leading to anxiety and depression‐like behaviors

Y Zuo, Y Hou, Y Wang, L Yuan, L Cheng, T Zhang

Journal of Pineal Research (Wiley) China, 12 January 2024

Neuroscience

Key words: Bmal1, circadian misalignment, mood, myelin, oligodendrocyte [more]

BNIP3 in hypoxia-induced mitophagy: Novel insights and promising target for non-alcoholic fatty liver disease

M Tian, J Hou, Z Liu, Z Li, D Huang, Y Zhang, Y Ma

The International Journal of Biochemistry & Cell Biology (Elsevier) China, 11 January 2024

Hepatology

Key words: BNIP3; Hypoxia; Mitophagy; NAFLD; β-oxidation. [more]

Unraveling the Role of miR-200b-3p in Attention-Deficit/Hyperactivity Disorder (ADHD) and Its Therapeutic Potential in Spontaneously Hypertensive Rats (SHR)

TM Chang, HL Lin, CC Tzang, JA Liang, TC Hsu, BS Tzang

Biomedicines (MDPI) Taiwan, 10 January 2024

Neuroscience

Key words: taurine, attention deficit hyperactivity disorder (ADHD), neuropsychiatric disorder, microRNA (miR)-200b-3p, striatum; spontaneously hypertensive rats (SHR), inflammatory factors, spontaneous alternations [more]

Effects of Citrus depressa Hayata juice on high-fat diet-induced obesity in HBV transgenic mice

PY Chu, CL Hsu, YA Lin, YC Pan, YH Dai, YC Yu, JC Yang, WL Ma, YJL Chen, CL Lee, YC Wu

Heliyon (Cell Press) Taiwan, 10 January 2024

Nutritional science

Key words: Citrus depressa hayata, Juice, fermentation, Polyphenol, Hesperidin, High-fat diet-induced obesity, HBV, Mice [more]

Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice

X Bai, B Wang, Y Cui, S Tian, Y Zhang, L You, YZ Chang, G Gao

Journal of Neuroinflammation (Springer) China, 09 January 2024

Neuroscience

Key words: Hepcidin, Iron, Alzheimer's disease, Hippocampal neurogenesis, Cognitive dysfunction [more]

Amyloid Burden Correlates with Electrocardiographic Findings in Patients with Cardiac Amyloidosis—Insights from Histology and Cardiac Magnetic Resonance Imaging

F Duca, R Rettl, C Kronberger, M Poledniczek, C Binder, D Dalos, M Koschutnik, C Donà, D Beitzke, C Loewe, C Nitsche, C Hengstenberg, R Badr-Eslam, J Kastner, J Bergler-Klein, AA Kammerlander

Journal of Clinical Medicine (MDPI) Austria, 09 January 2024

Cardiology

Key words: cardiac amyloidosis; transthyretin amyloidosis; light chain amyloidosis; electrocardiogram; histology; T1 mapping; extracellular volume; cardiac magnetic resonance imaging [more]

PD-L1-positive circulating endothelial progenitor cells associated with immune response to PD-1 blockade in patients with head and neck squamous cell carcinoma

NW Su, SH Dai, K Hsu, KM Chang, CC Ko, CW Kao, YF Chang, CG Chen

Cancer Immunology, Immunotherapy (Springer) Taiwan, 04 January 2024

Immunology, Oncology

Key words: PD-1, PD-L1, Head and neck cancer, Circulating endothelial cell, Circulating endothelial progenitor cell [more]

Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion

R Yan, P Zhang, S Shen, Y Zeng, T Wang, Z Chen, W Ma, J Feng, C Suo, T Zhang, H Wei, Z Jiang, R Chen, S Li, X Zhong, W Jia, L Sun, C Cang, H Zhang, P Gao

Nature Immunology (Nature) China, 04 January 2024

Oncology

[more]

Knockout of Shcbp1 sensitizes immunotherapy by regulating α‐SMA positive cancer‐associated fibroblasts

Q Gu, Z Ma, Q Wang, Y Dai, W Shi, Z Jiao

Molecular Carcinogenesis (Wiley) China, 03 January 2024

Oncology, Immunology

Key words: breast cancer, CAFs, Erdafitinib, ICT, Shcbp1 [more]

OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB

W Ma, Y Sun, R Yan, P Zhang, S Shen, H Lu, Z Zhou, Z Jiang, L Ye, Q Mao, N Xiong, W Jia, L Sun, P Gao, H Zhan

Molecular Cell (Cell Press) China, 03 January 2024

Oncology

[more]

Applications of Digital Pathology in Cancer: A Comprehensive Review

M Omar, MK Alexanderani, I Valencia, M Loda, L Marchionni

Annual Review of Cancer Biology (Annual Reviews) USA, UK, 02 January 2024

Oncology

Key words: digital pathology, whole-slide imaging, deep learning, artificial intelligence, cancer research, histopathology image analysis

USP29 alleviates the progression of MASLD by stabilizing ACSL5 through K48 deubiquitination

S Hu, Z Wang, K Zhu, H Shi, F Qin, T Zhang, S Tian, Y Ji, J Zhang, J Qin, Z She, X Zhang, P Zhang, H Li

Clinical and Molecular Hepatology (e-cmh.org) China, 02 January 2024

Hepatology, Molecular Biology

Key words: USP29, MASLD, ACSL5, Fatty acid β-oxidation, Deubiquitination [more]

Function and mechanism of GBP1 in the development and progression of cervical cancer

S Wang, Y Zhang, X Ma, Y Feng

Journal of Translational Medicine (BMC) China, 02 January 2024

Oncology

Key words: Guanylate binding protein 1 (GBP1), Tumor immunity, Cervical cancer, Alternative splicing (AS), Cancer promotion [more]

Effects of poly (ADP-ribose) polymerase inhibitor treatment on the repair process of ischemic acute kidney injury

J Jeon, K Lee, HR Jang, KE Yang, CJ Lee, H Ahn, WY Park, JE Lee, GY Kwon, YG Kim, W Huh

Scientific Reports (Nature) South Korea, 02 January 2024

Nephrology

Key words: Acute kidney injury, Inflammation [more]

Digitale Pathologie in Österreich

C Schatz, A Qerimi, J Haybaeck

Die Pathologie (Springer) Austria, 01 January 2024

Medical Image Analysis

Key words: Metadata whole slide images, Telepatholgy, AI, Diagnosis, whole slide images

Proteomics Analysis to Explore the Resistance Genes of Silkworm to Bombyx mori Nuclear Polyhedrosis Virus

G Ouyang, H Qian, J Sun, R Yang, T Gui, W Wang, Q Liu, A Chen

Genes (MDPI) China, 30 December 2023

Virology

Key words: B. mori, BmNPV, resistance gene, 2-DE, qRT-PCR [more]

Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury

CJ Yang, HC Chang, PC Sung, MC Ge, HY Tang, ML Cheng, HT Cheng, HH Chou, CY Lin, WR Lin, YS Lee, SY Hsieh

Cell Reports (Cell Press) Taiwan, 27 December 2023

Hepatology

[more]

In vivo imaging reveals a synchronized correlation among neurotransmitter dynamics during propofol and sevoflurane anesthesia.

GL Qiu, LJ Peng, P Wang, ZL Yang, JQ Zhang, H Liu, XN Zhu, J Rao, XS Liu

Zoological Research (search.ebscohost.com) China, 26 December 2023

Neuroscience

Key words: General anesthesia, Loss of consciousness, In vivo neurotransmitter imaging, Medial prefrontal cortex, Primary visual cortex

Electron irradiation of zein protein-loaded nano CaO2/CD for enhancing infectious diabetic wounds with adaptive hydrophobicity-to-hydrophilicity

L Zhou, S Guo, Z Dong, P Liu, W Shi, L Shen, J Yin

Materials Today Advances (Elsevier) China, 23 December 2023

Pharmacology

Key words: Diabetic wound healing, Antibacterial property, Reactive oxygen species, Inflammation suppression, Macrophage polarization, Adaptive hydrophobicity-to-hydrophilicity [more]

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

J Chen, Q Zheng, JL Hicks, L Trabzonlu, B Ozbek, , T Jones, AM Vaghasia, TC Larman, R Wang, MC Markowski, SR Denmeade, KJ Pienta, RH Hruban, ES Antonarakis, A Gupta, CV Dang, S Yegnasubramanian, AM De Marzo

JCI insight (The american society for clinical investigation) USA, 22 December 2023

Oncology

Key words: Metabolism, Oncology, Cancer, Mitochondria [more]

Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ

X Cai, R Wang, J Zhu, X Li, X Liu, G Ouyang, J Wang, Z Li, C Zhu, H Deng, W Xiao

Cell Reports (Cell Press) China, 20 December 2023

Immunology

Key words: Immunology, FIH, IKKϵ, MAVS, TBK1, TRAF3, hydroxylation, hypoxia, innate immunity, mouse, zebrafish [more]

Relationship between Aspartame-Induced Cerebral Cortex Injury and Oxidative Stress, Inflammation, Mitochondrial Dysfunction, and Apoptosis in Sprague Dawley Rats

J U-pathi, YC Yeh, CW Chen, EE Owaga, RH Hsieh

Antioxidants (MDPI) Taiwan, Kenya, 19 December 2023

Nutritional science

Key words: aspartame, inflammation, oxidative stress, mitochondrial biogenesis, apoptosis [more]

Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits

WL Septiana, W Ayudyasari, H Gunardi, JA Pawitan, GM Balachander, H Yu, RD Antarianto

In Vitro Cellular & Developmental Biology - Animal (Springer) Indonesia, Singapore, India, 18 December 2023

Hepatology

Key words: Liver organoid, iPSCs, Hepatocyte-differentiation, Transplant, Liver failure [more]

Renoprotective effects of extracellular fibroblast specific protein 1 via nuclear factor erythroid 2-related factor-mediated antioxidant activity

N Takahashi, S Yokoi, H Kimura, H Naiki, T Matsusaka, Y Yamamoto, K Nakatani, K Kasuno, M Iwano

Scientific Reports (Nature) Japan, 18 December 2023

Nephrology

Key words: Medical research, Nephrology [more]

Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling

Y Wang, M Yao, C Li, K Yang, X Qin, L Xu, S Shi, C Yu, X Meng, C Xie

Experimental Hematology & Oncology (BMC) China, 16 December 2023

Oncology

Key words: KRASG12C, c-Myc, PLK1, LncRNA, ST8SIA6-AS1, Drug resistance [more]

Melatonin exhibits partial protective effects against gemcitabine-and cisplatin-induced kidney and reproductive injuries in mice

SC Wang, HC Hsu, YC Chang, CY Yu, CT Liu, WW Sung

Aging (Impact Journals) Taiwan, 14 December 2023

Nephrology, Reproductive Medicine

Key words: melatonin, hormone, testosterone, sperm, chemotherapy [more]

In silico analyses of pan-squamous cell carcinoma unveiled the immunological implications of MRPL13, which had previously been under-recognized

Y Liang, S He, Y Tan, Q Liu, F Zhao, T Liu, C Huang, X Lu, S Zheng

Heliyon (Cell) China, 14 December 2023

Oncology, Immunology

Key words: MRPL13, Pan-squamous cell carcinoma, Bioinformatics analysis, Prognostic, CD8+ T-cell infiltration [more]

Egocentric processing of items in spines, dendrites, and somas in the retrosplenial cortex

N Cheng, Q Dong, Z Zhang, L Wang, X Chen, C Wang

Neuron (Cell Press) China, 14 December 2023

Neuroscience

Key words: retrosplenial, egocentric, dendrite, spine, goal, context, landmark [more]

Static Magnetic Field Reduces Intracellular ROS Levels and Protects Cells Against Peroxide-Induced Damage: Suggested Roles for Catalase

ECG Frachini, JB Silva, B Fornaciari, MS Baptista, H Ulrich, DFS Petri

Neurotoxicity Research (Springer) Brazil, 14 December 2023

Neuroscience

Key words: External magnetic field, Oxidative stress, Neuroprotection, SH-SY5Y cells, Cell proliferation [more]

ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-Guided Analysis

VA Arrieta, J Duerinck, KB Burdett, KJ Habashy, W Geens, A Gould, JK Schwarze, C Dmello, KS Kim, R Saganty, L Chen, A Moscona, M McCord, C Lee-Chang, CM Horbinski, H Zhang, R Stupp, B Neyns, AM Sonabend

Clinical Cancer Research (AACR) Belgium, USA, Mexico, 13 December 2023

Oncology, Pharmacology

[more]

Chlamydia suis survival in dust: First insights–A short communication

C Unterweger, M Koch, S Winkler, S Hammer, A Oppeneder, A Ladinig

Research in Veterinary Science (Elsevier) Austria, 13 December 2023

Microbiology

Key words: Chlamydia suis, Pigs, Dust, Transmission, Disinfection, Viability [more]

The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development

MF Chen, CC Hu, YH Hsu, YC Lin, KL Chen, SWN Ueng, Y Chang

Bone & Joint Research (The British Editorial Society of Bone & Joint Surgery) Taiwan, 12 December 2023

Osteology

Key words: Osteoarthritis, EDIL3, Chondrocyte, Extracellular matrix, Cartilage, osteoarthritic changes, cartilage tissues, extracellular matrix, chondrocytes, antibodies, interleukin, aggrecan, pro-inflammatory cytokines, OARSI, subchondral bone plate [more]

Differential effects of microRNAs miR‐21, miR‐99 and miR‐145 on lung regeneration and inflammation during recovery from influenza pneumonia

JWJ Ong, KS Tan, JJX Lee, JE Seet, HW Choi, SG Ler, J Gunaratne, T Narasaraju, L-T Sham, V Patzel, VT Chow

Journal of Medical Virology (Wiley Online Library) Singapore, India, UK, 12 December 2023

Pulmonology

Key words: influenza, lung regeneration, microRNAs, miR-21, mi-99a, miR-145, pneumonia, proliferating AT2 cells, RNA sequencing, stem cells [more]

Corynoline inhibits esophageal squamous cell carcinoma growth via targeting Pim-3

Y Shi, Q Yuan, Y Chen, X Li, Y Zhou, H Zhou, F Peng, Y Jiang, Y Qiao, J Zhao, C Zhang, J Wang, K Liu, Z Dong

Phytomedicine (Elsevier) China, 12 December 2023

Oncology, Pharmacology

Key words: Proviral integration site for maloney murine leukemia virus 3, corynoline, esophageal squamous cell carcinoma, proliferation, apoptosis [more]

Granzyme K–and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease

R Koga, T Maehara, R Aoyagi, R Munemura, Y Murakami, A Doi, M Kono, H Yamamoto, H Niiro, T Kiyoshima, M Tanabe, T Nakano, Y Matsukuma, M Kawano, JH Stone, S Pillai, S Nakamura, S Kawano

Journal of Allergy and Clinical Immunology (Elsevier) Japan, USA, 11 December 2023

Immunology

Key words: Single-cell RNA sequencing, IgG4-related disease, granzyme K, cytotoxic T cells, fibrosis, amphiregulin, double-negative (DN) B [more]

Hypoxia is correlated with the tumor immune microenvironment: Potential application of immunotherapy in bladder cancer

H Chen, Y Zhang, X Chen, R Xu, Y Zhu, D He, Y Cheng, Z Wang, X Qing, K Cao

Cancer Medicine (Wiley Online Library) China, 08 December 2023

Oncology, Pharmacology

Key words: bladder cancer, hypoxia, immune checkpoint inhibitorn TLR8, tumor microenviorment [more]

A breast cancer classification and immune landscape analysis based on cancer stem-cell-related risk panel

H Hu, M Zou, H Hu, Z Hu, L Jiang, D Escobar, H Zhu, W Zhan, T Yan, T Zhang

NPJ Precision Oncology (Nature) China, USA, 08 December 2023

Oncology

Key words: Cancer genomics, Prognostic markers [more]

Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis

YY Wang, KH Cheng, AC Hung, S Lo, PY Chen, YC Wu, MF Hou, SSF Yuan

International Journal of Oncology (Spandios Publications) Taiwan, 07 December 2023

Oncology, Molecular Biology

[more]

Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer

W Tang, G Li, Q Lin, Z Zhu, Z Wang, Z Wang

Journal of Translational Medicine (Springer) China, 07 December 2023

Oncology

Key words: Gastric cancer, Cholersterol metabolism, Metabolic subtypes, Immunotheerapy, Prognostic signature, Biomarkers [more]

Pro‐inflammatory cytokine IL‐6 regulates LMO4 expression in psoriatic keratinocytes via AKT/STAT3 pathway

Z Tu, W Wei, Q Xiang, W Wang, S Zhang, H Zhou

Immunity, Inflammation and Disease (Wiley Online Library) China, 06 December 2023

Dermatology, Molecular Biology

Key words: AKT, interleukin‐6, LMO4, psoriasis, STAT3 [more]

ALDOB/KAT2A interactions epigenetically modulate TGF-β expression and T cell functions in hepatocellular carcinogenesis

C Yin, C Zhang, Y Wang, G Liu, N Wang, N Liang, L Zhang, Q Tu, J Lv, H Jiang, H Ma, C Du, M Li, X He, S Chen, J Guo, S Li, J Qin, N Li, Y Tao, H Yin

Hepatology (AASLD) China, 05 December 2023

Hepatology, Oncology

[more]

Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma

J Duan, Y Zhang, R Chen, L Liang, Y Huo, S Lu, J Zhao, C Hu, Y Sun, K Yang, M Chen, Y Yu, J Ying, R Huang, X Ma, S Leaw, F Bai, Z Shen, S Cai, D Gao, J Wang, Z Wang

Cell Reports Medicine (Cell Press) China, 04 December 2023

Oncology, Pharmacology

Key words: squamous NSCLC, PD-1 blockade, biomarkers PD-L1, tumor mutational burden, gene expression signature, NRF2, tislelizumab clinical trial, immunotherapy [more]

SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats

A Shankar, CK Deal, S McCahon, K Callegari, T Seitz, L Yan, DM Drown, CT Williams

Chronobiology International (Taylor & Francis) USA, 04 December 2023

Nutritional science, Gastroenterology

Key words: Photoperiod, seasonal affective disorder, metabolic dysbiosis, non-alcoholic fatty liver disease [more]

Excessive Lipid Peroxidation in Uterine Epithelium Causes Implantation Failure and Pregnancy Loss

Y Lu, Y Shao, W Cui, Z Jia, Q Zhang, Q Zhao, ZJ Chen, J Yan, B Chu, J Yuan

Advanced Science (Wiley) China, 03 December 2023

Reproductive Medicine

[more]

A prognostic model based on Scissor+ cancer associated fibroblasts identified from bulk and single cell RNA sequencing data in head and neck squamous cell carcinoma

G Tian, J Zhang, Y Bao, Q Li, J Hou

Cellular Signalling (Elsevier) China, 03 December 2023

Oncology

Key words: HNSCC, Fibroblasts, Scissor, scRNA-seq [more]

Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway

XC Wang, XL Li, XN Ma, LD Zhang, TY Han, DK Zhang

Naunyn-Schmiedeberg's Archives of Pharmacology (Springer) China, 02 December 2023

Gastroenterology, Pharmacology

Key words: Autophagy, Dihydromyricetin, Inflammatory bowel disease, Intestinal fibrosis [more]

Downregulation of N4-acetylcytidine modification in myeloid cells attenuates immunotherapy and exacerbates hepatocellular carcinoma progression

N Xu, J Zhuo, Y Chen, R Su, H Chen, Z Zhang, Z Lian, D Lu, X Wei, S Zheng, X Xu, S Wang, Q Wei

British Journal of Cancer (Nature) China, 01 December 2023

Oncology, Pharmacology

Key words: Cancer immunotherapy, Translational research [more]

Spatiotemporal characterization of glial cell activation in an Alzheimer's disease model by spatially resolved transcriptomics

H Choi, EJ Lee, JS Shin, H Kim, S Bae, Y Choi, DS Lee

Experimental & Molecular Medicine (Nature) South Korea, 01 December 2023

Neuroscience

Key words: Alzheimer's disease, Transcriptomics, Translational research [more]

Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury

K Štepánková, M Chudíčková, Z Šimková, N Martinez-Varea, S Kubinová, L Machová Urdzíková, P Jendelová, JF Kwok

Scientific Reports (Nature) Czech Republic, UK, 29 November 2023

Neuroscience, Pharmacology

Key words: Molecular neuroscience, Regeneration and repair in the nervous system, Synaptic plasticity [more]

Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development

T Vanova, J Sedmik, J Raska, KA Cerna, P Taus, V Pospisilova, M Nezvedova, V Fedorova, S Kadakova, H Klimova, M Capandova, P Orviska, P Fojtik, S Bartova, K Plevova, Z Spacil, H Hribkova, D Bohaciakova

Cell Reports (Cell) Czech Republic, 28 November 2023

Neuroscience

[more]

Low-intensity exercise training increases systolic function of heart and MHCII low cardiac resident macrophages

G Wang, L Wang, X Wang, H Ye, W Ni, W Shao, C Dai, B Liu

Heliyon (Cell Press) China, 28 November 2023

Cardiology

Key words: Cardiac macrophage, Ejection fraction, Heart, Low-intensity exerciseInnate immunity [more]