Customer Publications (A total of 2946 papers published)

Nuclear factor of activated T-cells 5 is indispensable for a balanced adaptive transcriptional response of lung endothelial cells to hypoxia

H Laban, S Siegmund, K Schlereth, FA Trogisch, A Ablieh, L Brandenburg, A Weigert, C De La Torre, C Mogler, M Hecker, WM Kuebler, T Korff

Cardiovascular Research (Oxford Academic) Germany, 06 August 2024

Molecular Biology

Key words: NFAT5, Hypoxia, Endothelial cells, Pulmonary hypertension, Transcriptome

Unlocking the potential of HHLA2: identifying functional immune infiltrating cells in the tumor microenvironment and predicting clinical outcomes in laryngeal squamous cell carcinoma

W Li, J You, H Xue, Y Liu, J Chen, X Zheng, L Chen, C Wu

Cancer Immunology, Immunotherapy (Springer) China, 06 August 2024

Oncology, Immunology

Key words: Laryngeal squamous cell carcinoma, HHLA2, Immune infiltrating cell, Prognosis [more]

Ribonucleotide reductase small subunit M2 promotes the proliferation of esophageal squamous cell carcinoma cells via HuR-mediated mRNA stabilization

J Zhang, Q Wu, Y Xie, F Li, H Wei, Y Jiang, Y Qiao, Y Li, Y Sun, H Huang, M Ge, D Zhao, Z Dong, K Liu

Acta Pharmaceutica Sinica B (Elsevier) China, 03 August 2024

Oncology

Key words: Esophageal squamous cell carcinoma (ESCC), Bifonazole, Ribonucleotide reductase small subunit M2 (RRM2), AU-rich elements (AREs), Hu antigen R (HuR), mRNA stability, dNTP, Cell proliferation [more]

Impact of sensory neuropeptide deficiency on behavioral patterns and gait in a murine surgical osteoarthritis model

AE Rapp, A Wolter, D Muschter, S Grässel, A Lang

Journal of Orthopaedic Research (Wiley) Germany, USA, 03 August 2024

Neuroscience

Key words: cartilage, gait, osteoarthritis [more]

Safety and reactogenicity of a controlled human infection model of sand fly-transmitted cutaneous leishmaniasis

V Parkash, H Ashwin, S Dey, J Sadlova, B Vojtkova, K Van Bocxlaer, R Wiggins, D Thompson, N Sharma Dey, CL Jaffe, E Schwartz, P Volf, CJN Lacey, AM Layton, PM Kaye

Nature Medicine (Nature) UK, Czech Republic, Israel, 02 August 2024

Immunology

Key words: Parasitic infection, Vaccines [more]

A model of tertiary lymphatic structure-related prognosis for penile squamous cell carcinoma

H Tang, Z Su, Q Huang, Y Li, R Chen, C Ban, C Liu, H Lu, XL Yi, Y Tong

BMC urology (Springer) China, 02 August 2024

Oncology

Key words: Penile squamous cell carcinoma, Tertiary lymphoid structure, Immunity, Lymphocytes [more]

Targeted inhibition of m6A demethylase FTO by FB23 attenuates allergic inflammation in the airway epithelium

Z Lian, R Chen, M Xian, P Huang, J Xu, X Xiao, X Ning, J Zhao, J Xie, J Duan, B Li, W Wang, X Shi, X Wang, N Jia, X Chen, J Li, Z Yang

The FASEB Journal (Wiley) China, 02 August 2024

Immunology

Key words: allergic inflammation, asthma, epithelial cells, FTO, m6A [more]

Astrocyte‐derived factors regulate CNS myelination

S Seiler, F Rudolf, FR Gomes, A Pavlovic, J Nebel, CI Seidenbecher, LC Foo

Glia (Wiley) Switzerland, Germany, 02 August 2024

Neuroscience

Key words: ACM, astrocytes, brevican, MS, myelination, reactive astrocytes [more]

Driver mutation subtypes involve with differentiated immunophenotypes influencing pancreatic cancer outcomes

S Zou, L Zhang, C Jiang, F Li, Y Yang, X Deng, J Zhang, H Chen, L Jiang, X Cheng, L Deng, L Lin, B Shen, C Wen, Q Zhan

Cancer Letters (Elsevier) China, 31 July 2024

Oncology, Immunology

Key words: Pancreatic adenocarcinoma, Immunophenotypes, KRAS G12V, Tumor-specific CD4+ T cells, Neoantigen [more]

An mpox quadrivalent mRNA vaccine protects mice from lethal vaccinia virus challenge

E Li, Q Gong, J Zhang, X Guo, W Xie, D Chen, Y Shen, D Hong, Z Li, Q Wang, C Wang, Y Wang, S Chiu

Antiviral Research (Elsevier) China, 31 July 2024

Vaccinology, Virology

Key words: monkeypox virus, multivalent mRNA vaccine, humoral immune response, cellular immune responses, vaccinia virus [more]

Downregulation of IL-11 regulates the TGFβ/ERK1/2 signaling pathway to inhibit articular capsule fibrosis and alleviate post-traumatic articular capsule contracture

H Zheng, ZJ Zhong, YC Wang, YB Sun, FF Li

Journal of Shoulder and Elbow Surgery (Elsevier) China, 30 July 2024

Rheumatology

Key words: Interleukin 11; fibrosis; post-traumatic joint capsule contracture; 30 transforming growth factor-β; collagen [more]

Correlated multimodal imaging in life sciences: lessons learnt

PS Rudraiah, R Camacho, J Fernandez-Rodriguez, D Fixler, J Grimm, F Gruber, M Kalaš, C Kremslehner, C Kuntner, D Kuzdas-Wood, J Lindblad, JG Mannheim, M Marchetti-Deschmann, P Paul-Gilloteaux, P Sampaio, P Sandbichler, A Sartori-Rupp, N Sladoje, P Verkade, A Walter, S Zoratto

Frontiers in Biomaterials Science (Frontiers Media S.A.) , 30 July 2024

Biomaging

Metabolic reprogramming and heterogeneity during the decidualization process of endometrial stromal cells

Z Jia, Y Wei, Y Zhang, K Song, J Yuan

Cell Communication and Signaling (Springer) China, 30 July 2024

Reproductive Medicine

Key words: Decidualization, Lipid metabolism, Amino acid metabolism, Human endometrium [more]

Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology

M Ji, S Weng, X Li, Q Xiao, Y Tong, Y Zhou, T Luo, Z Liu

Naunyn-Schmiedeberg's Archives of Pharmacology (Springer) China, 29 July 2024

Reproductive Medicine, Pharmacology

Key words: PI3K/Akt signaling pathway, Premature ovarian failure, Apoptosis, Imatinib, Quercetin, Network pharmacology analysis [more]

AQP4-and Kir4. 1-Mediated Müller Cell Oedema Is Involved in Retinal Injury Induced By Hypobaric Hypoxia

C Han, Y Li, XX Zheng, XX Zhang, G Li, L Zhao, ZQ Chen, Y Yang, W Zhang

Molecular Neurobiology (Springer) China, 26 July 2024

Ophthalmology, Neuroscience

Key words: Hypobaric hypoxia, Müller cells, AQP4, Kir4.1, High-altitude retinopathy [more]

A rat model of cerebral small vascular disease induced by ultrasound and protoporphyrin

WM Lu, HN Ji, RH Yang, KL Cheng, XL Yang, HL Zeng, K Tao, DM Yin, DH Wu

Biochemical and Biophysical Research Communications (Elsevier) China, 25 July 2024

Neuroscience

Key words: cerebral small vascular disease, rat model, ultrasound, cerebral microinfarction, white matter injury, protoporphyrin [more]

Mitochondrial respiration in microglia is essential for response to demyelinating injury but not proliferation

JS Stoolman, RA Grant, TA Poor, SE Weinberg, KB D’Alessandro, J Tan, JY Hu, ME Zerrer, WA Wood, MC Harding, S Soni, KM Ridge, PT Schumacker, GR Budinger, NS Chandel

Nature Metabolism (Nature) USA, 24 July 2024

Neuroscience, Cell Biology

Key words: Metabolism, Microglia, Mitochondria, Neuroscience [more]

Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19

TZ Wen, TR Li, XY Chen, HY Chen, S Wang, WJ Fu, SQ Xiao, J Luo, R Tang, JL Ji, JF Huang, ZC He, T Luo, HL Zhao, C Chen, JY Miao, Q Niu, Y Wang, XW Bian, XH Yao

Metabolism (Elsevier) China, 23 July 2024

Endocrinology, SARS-CoV-2

Key words: Adrenal gland, COVID-19, Steroidogenesis, Proteomics, Histopathology, Autopsy [more]

Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm

YK Hong, TL Cheng, CK Hsu, FT Lee, BI Chang, KC Wang, LY Chang, HL Wu, CH Lai

International Journal of Biological Sciences (Ivyspring) Taiwan, USA, 20 July 2024

Cardiology, Molecular Biology

Key words: Tumor endothelial marker 1 (TEM1, CD248, endosialin), abdominal aortic aneurysm (AAA), vascular smooth muscle cell, fibroblast, phenotypic change, collagen synthesis [more]

The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer

Y Hou, B Lin, T Xu, J Jiang, S Luo, W Chen,X Chen, Y Wang, G Liao, J Wang, J Zhang, X Li, X Xiang, Y Xie, J Wang, S Peng, W Lv, Y Liu, H Xiao

Nature Communications (Nature) China, 19 July 2024

Oncology

Key words: Cancer microenvironment, Thyroid cancer, Tumour immunology [more]

GPR34 senses demyelination to promote neuroinflammation and pathologies

B Lin, Y Zhou, Z Huang, M Ma, M Qi, Z Jiang, G Li, Y Xu, J Yan, D Wang, X Wang, W Jiang, R Zhou

Cellular & Molecular Immunology (Nature) China, 19 July 2024

Neuroscience, Immunology

Key words: Neuroinflammation, GPCRs, Microglia, Inflammation, Neuroimmunology

Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells.

MT Latancia, G da Silva Leandro, AU Bastos, N Cestari Moreno, A Adetayo Ariwoola, D Jardim Martins, NW Ashton, V Chaves Ribeiro, NC Hoch, C Ribeiro Reily Rocha, R Woodgate, CF Martins Menck

DNA repair (Elsevier) Brazil, 18 July 2024

Oncology

Key words: Glioma, Temozolomide, Translesion synthesis, Cancer, Chemotherapy resistance, DNA polymerase [more]

Boron Neutron Capture Therapy‐Derived Extracellular Vesicles via DNA Accumulation Boost Antitumor Dendritic Cell Vaccine Efficacy

L Lv, J Zhang, Y Wang, H Liang, Q Liu, F Hu, H Li, W Su, J Zhang, R Chen, Z Chen, Z Wang, J Li, R Yan, M Yang, YN Chang, J Li, T Liang, G Xing, K Chen

Advanced Science (Wiley) China, 17 July 2024

Oncology, Immunology

[more]

NME4 suppresses NFκB2‐CCL5 axis, restricting CD8+ T cell tumour infiltration in oesophageal squamous cell carcinoma

S Zheng, S He, Y Liang, Q Liu, T Liu, Y Tan, T Peng, C Huang, H Gao, X Lu

Immunology (Wiley) China, 17 July 2024

Oncology, Immunology

Key words: CCL5, CD8T, NFκB2, NME4, oesophageal squamous cell carcinoma [more]

Eupalinolide B suppresses pancreatic cancer by ROS generation and potential cuproptosis

Q Huang, J Yang, J Zhang, L Yao, B Jiang, S Du, F Li, Q Peng, L Qin, Y Wang, L Qi

iScience (Cell Press) China, 13 July 2024

Oncology

[more]

3D hUC-MSC spheroids exhibit superior resistance to autophagy and apoptosis of granulosa cells in POF rat model

W Dai, H Yang, B Xu, T He, L Liu, Z Zhang, L Ding, X Pei, X Fu

Reproduction (Society for Reproduction and Fertility) China, 13 July 2024

Reproductive Medicine

[more]

Divergent histopathological and molecular patterns in chemically induced interstitial cystitis/bladder pain syndrome rat models

YC Chang, CY Yu, C Dong, SL Chen, WW Sung

Scientific Reports (Natue) Taiwan, 12 July 2024

Urology, Pathology

Key words: Interstitial cystitis, Bladder pain syndrome, Next-generation sequencing, RNA sequencing, Kyoto encyclopedia of genes and genomes [more]

Targeted redox-responsive peptide for arterial chemoembolization therapy of orthotropic hepatocellular carcinoma

Y Xia, X Li, F Liu

Abdominal Radiology (Springer) China, 11 July 2024

Oncology

Key words: Drug delivery, Hepatocellular carcinoma, Peptide, Transcatheter arterial chemoembolization [more]

N-acetyl Cysteine Overdose Induced Acute Toxicity and Hepatic Microvesicular Steatosis by Disrupting GSH and Interfering Lipid Metabolisms in Normal Mice

MS Tsai, GG Liou, JW Liao, PY Lai, DJ Yang, SH Wu, SH Wand

Antioxidants (MDPI) Taiwan, 11 July 2024

Toxicology, Hepathology

Key words: NAC overdose; glutathione; microvesicular steatosis; β-oxidation; non-alcoholic fatty liver

Chronic Partial Sleep Deprivation Increased the Incidence of Atrial Fibrillation by Promoting Pulmonary Vein and Atrial Arrhythmogenesis in a Rodent Model

SH Liu, FJ Lin, YH Kao, PH Chen, YK Lin, YY Lu, YC Chen, YJ Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 11 July 2024

Cardiology

Key words: sleep deprivation; heart failure; atrial fibrillation; G protein-coupled receptor kinase 2 (GRK2) [more]

Unveiling the role of TAGLN2 in glioblastoma: From proneural-mesenchymal transition to Temozolomide resistance

Y Li, X Wang, T Xu, F Xu, T Chen, Z Li, Y Wang, H Chen, J Ming, J Cai, C Jiang, X Meng

Cancer Letters (Elsevier) China, 09 July 2024

Oncology, Molecular Biology

Key words: TAGLN2, Glioblastoma, Proneural-to-mesenchymal transition, Temozolomide resistance, ERK/MGMT axis [more]

Exploring the multifaceted therapeutic mechanism of Schisanlactone E (XTS) in APP/PS1 mouse model of Alzheimer's disease through multi-omics analysis

Z Song, J He, W Yu, C He, M Yang, P Li, Z Li, G Jian, S Cheng

Frontiers in Microbiology (Frontiers Media S.A.) China, 09 July 2024

Neuroscience

Key words: Schisanlactone E, Alzheimer’s disease, 16S rDNA, metabolomics, Akkermansia, 4-methylcatechol, microbial-gut-brain axis [more]

Knockdown of AMIGO2 suppresses proliferation and migration through regulating PPAR-γ in bladder cancer

D Han, B Xiong, X Zhang, C Chen, Z Yao, H Wu, J Cao, J Li, P Li, Z Wang, J Tian

Hereditas (Springer) China, 08 July 2024

Oncology

Key words: AMIGO2, PPAR-γ, RNA-Sew, TMA, Bladder cancer [more]

Endogenous hydrogen sulfide accelerated trauma-induced heterotopic ossification through the Ca2+/ERK pathway-enhanced aberrant osteogenic activity

Z Yuan, J Li, K He, Z Sun, G Luo, H Liu, J Dong, C Zhou, H Cui, C Fan

Redox Biology (Elsevier) China, 06 July 2024

Osteology

Key words: Trauma-induced heterotopic ossification, Hydrogen sulfide, Sulfur metabolic enzyme, Ca2+/ERK pathway, Chirality [more]

γδ T cells in human colon adenocarcinomas comprise mainly Vδ1, Vδ2, and Vδ3 cells with distinct phenotype and function

W Rodin, L Szeponik, T Rangelova, FT Kebede, T Österlund, P Sundström, S Hogg, Y Wettergren, A Cosma, A Ståhlberg, EB Lindskog, MQ Järbrink

Cancer Immunology, Immunotherapy (Springer) Sweden, Luxembourg, 02 July 2024

Oncology

Key words: γδ T cells, Colon cancer, Tumour immunity, TCRδ chain [more]

Suppressing SENP1 inhibits esophageal squamous carcinoma cell growth via SIRT6 SUMOylation

J Gu, S Zhang, D Lin, W Wang, J Cheng, Q Zheng, H Wang, L Tan

Cellular Oncology (Springer) China, 02 July 2024

Oncology

Key words: Esophageal squamous cell carcinoma, SENP1, Cell cycle, SUMOylation, SIRT6 [more]

Recruitment of neutrophils in glomeruli in early mouse sepsis is associated with E-selectin expression and activation of endothelial NF-κB and MAPK pathways

Z Wang, EZ Dayang, PJ Zwiers, ML Hernandez Garcia, M Luxen, M van Meurs, JAM Kamps, J Moser, G Molema

Journal of Leukocyte Biology (Oxford Academic) The Netherlands, 02 July 2024

Immunology, Nephrology

Key words: polymicrobial abdominal sepsis, kidney, leukocytes, endothelial cells, endothelial adhesion molecules, NF-κB p65, MAPK c-Jun [more]

Effect of Early Inhibition of Toll-Like Receptor 4 on Hippocampal Plasticity in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage

Q Li, Z Ouyang, Y Zhang, Z Li, X Zhu, Z Tang

Molecular Neurobiology (Springer) China, 02 July 2024

Neuroscience

Key words: Hypoxic-ischemia, Brain injury, Hippocampus plasticity, TLR4, Rat [more]

Dihydromyricetin ameliorates experimental ulcerative colitis by inhibiting neutrophil extracellular traps formation via the HIF-1α/VEGFA signaling pathway

X Ma, M Li, X Wang, H Xu, L Jiang, F Wu, L Wei, G Qi, D Zhang

International Immunopharmacology (Elsevier) China, 01 July 2024

Gastroenterology, Immunology

Key words: Dihydromyricetin, Ulcerative colitis, Neutrophil extracellular traps, HIF-1α, VEGFA [more]

Comparative Analysis of Osteointegration in Hydroxyapatite and Hydroxyapatite-Titanium Implants: An In Vivo Rabbit Model Study

RM Văruț, LT Rotaru, FN Truicu, CE Singer, I Iulian-Nicolae, AIS Popescu, C Popescu, C Teisanu, G Sima, OE Nicolaescu

Journal of Functional Biomaterials (MDPI) Romania, 29 June 2024

Osteology

Key words: bioceramic; two-steps sintering; osteointegration [more]

Growth, Antioxidant Capacity, and Liver Health in Largemouth Bass (Micropterus salmoides) Fed Multi-Strain Yeast-Based Paraprobiotic: A Lab-to-Pilot Scale Evaluation

J Wang, X Xie, Y Liu, J Liu, X Liang, H Wang, G Li, M Xue

Antioxidants (MDPI) China, 28 June 2024

Nutritional science

Key words: largemouth bass; multi-strain yeast-based paraprobiotics; pilot-scale experiment; antioxidant capacity; immune responses; liver health [more]

HMGB1-Mediated Cell Death—A Crucial Element in Post-Hepatectomy Liver Failure

L Brunnthaler, TG Hammond, D Pereyra, J Santol, J Probst, V Laferl, U Resch, M Aiad, AS Janoschek, T Gruenberger, H Hackl, P Starlinger, A Assinger

International Journal of Molecular Science (MDPI) Austria, Switzerland, 28 June 2024

Hepathology

Key words: partial hepatectomy; post hepatectomy liver failure; HMGB1; caspase-cleaved keratin-18 [more]

Rosmarinic acid Liposomes Suppress Ferroptosis in Ischemic Brain via Inhibition of TfR1 in BMECs

C Jia, Y Gou, Y Gao, X Pei, X Jin, B Li, Z Zhang, Y He, ES Ji, Y Zhao

Phytomedicine (Elsevier) China, 28 June 2024

Neuroscience

Key words: Ischemic stroke, Transferrin receptor protein 1, Ferroptosis, Rosmarinic acid, Nanoliposomes [more]

First in vitro cell co-culture experiments using laser-induced high-energy electron FLASH irradiation for the development of anti-cancer therapeutic strategies

S Orobeti, LE Sima, I Porosnicu, C Diplasu, G Giubega, G Cojocaru, R Ungureanu, C Dobrea, M Serbanescu, A Mihalcea, E Stancu, CE Staicu, F Jipa, A Bran, E Axente, S Sandel, M Zamfirescu, I Tiseanu, F Sima

Scientific Reports (Nature) Romania, 27 June 2024

Oncology, Pharmacology

Key words: Laser-produced plasmas, Radiotherapy, wide-field fluorescence mircoscopy [more]

Fasting-induced miR-7a-5p in AgRP neurons regulates food intake

M Yuan, Z Cao, Q Li, R Liu, J Wang, W Xue, Q Lyu

Metabolism (Elsevier) China, 26 June 2024

Neuroscience

Key words: microRNA, AgRP neurons, Food intake, Energy homeostasis, Obesity, Fasting [more]

Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms

D Chen, C Zhao, J Zhang, CWJ Knol, A Osipyan, N Majerníková, T Chen, Z Xiao, J Adriana, AJ Griffith, AS Gamez, PE van der Wouden, RP Coppes, AM Dolga, HJ Haisma, FJ Dekker

Advanced Science (Wiley) The Netherlands, 25 June 2024

Oncology

AIM2 enhances Candida albicans infection through promoting macrophage apoptosis via AKT signaling

Q Jiang, Y Chen, S Zheng, L Sui, D Yu, F Qing, W He, Q Xiao, T Guo, L Xu, Z Liu, Z Liu

Cellular and Molecular Life Sciences (Springer) China, 25 June 2024

Immunology

Key words: AIM2, Candida albicans, Macrophage, Apoptosis, AKT [more]

FOXO1 induced fatty acid oxidation in hepatic cells by targeting ALDH1L2

J Cheng, S Yang, D Shou, J Chen, Y Li, C Huang, H Chen, Y Zhou

Journal of Gastroenterology and Hepatology (Wiley) China, 25 June 2024

Metabolism, Hepathology

Key words: ALDH1L2, fatty acid oxidation, FOXO1, NAFLD [more]

Creation of a biological sensorimotor interface for bionic reconstruction

C Festin, J Ortmayr, U Maierhofer, V Tereshenko, R Blumer, M Schmoll, GR Carrero-Rojas, M Luft, G Laengle, D Farina, KD Bergmeister, OC Aszmann

Nature Communications (Nature) Austria, UK, USA, 24 June 2024

Biomedical Engineering

Key words: Peripheral nervous system, Regeneration and repair in the nervous system, Translational research [more]

Adoptive Cell Therapy in Mice Sensitized to a Grass Pollen Allergen

AM Weijler, L Prickler, V Kainz, E Bergmann, B Bohle, H Regele, R Valenta, B Linhart, T Wekerle

Antibodies (MDPI) Austria, Russia, 18 June 2024

Immunology

Key words: cell therapy; allergy; Phl p 5; tolerance; mouse model [more]

Vimentin, inversely correlating with infiltration of CD8+ T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma

Y Liang, S He, Q Liu, T Liu, Y Tan, T Peng, C Huang, X Lu, S Zheng

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (Elsevier) China, 18 June 2024

Oncology

Key words: Vimentin, CD8T, PD-L1, PD-L2, Translocation, ESCC [more]

Cytotoxic Oxidative Stress Effects of Neutrophil Extracellular Traps' Components on Cattle Spermatozoa

R Rivera-Concha, M León, A Prado-Sanhueza, R Sánchez, A Taubert, C Hermosilla, P Uribe, F Zambrano

Antioxidants (MDPI) Chile, Germany, 17 June 2024

Reproductive Medicine

Key words: cattle; neutrophil extracellular traps; spermatozoa; oxidative stress [more]

High dietary Fructose Drives Metabolic Dysfunction-Associated Steatotic Liver Disease via Activating ubiquitin-specific peptidase 2/11β-hydroxysteroid dehydrogenase type 1 Pathway in Mice

C Li, M Li, W Sheng, W Zhou, Z Zhang, G Ji, L Zhang

International Journal of Biological Sciences (IJBS) China, 17 June 2024

Nutritional science

Key words: dietary fructose, MASLD, hepatic steatosis, inflammation, USP2 [more]

Concomitant NAFLD Facilitates Liver Metastases and PD-1-Refractory by Recruiting MDSCs via CXCL5/CXCR2 in Colorectal Cancer

Y Yang, Y Chen, Z Liu, Z Chang, Z Sun, L Zhao

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) China, 14 June 2024

Oncology, Hepathology

Key words: Nonalcoholic Fatty Liver Disease, Colorectal Cancer, Liver Metastasis, Myeloid-Derived Suppressor Cells, Immune-Checkpoint Inhibitors [more]

Antibody nanoparticle conjugate–based targeted immunotherapy for non–small cell lung cancer

T Saha, M Fojtu, AV Nagar, L Thurakkal, B Srinivasan, M Mukherjee, A Sibiyon, H Aggarwal, A Samuel, C Dash, HL Jang, S Sengupta

Science Advances (Science) USA, 14 June 2024

Oncology, Nanomedicine

[more]

Noninvasive Transdermal Administration of mRNA Vaccines Encoding Multivalent Neoantigens Effectively Inhibits Melanoma Growth

Y Hou, Z Wang, Z Chen, L Shuai, Y Pei, B Sun, Y Jiang, H Wang

ACS Biomaterials Science and Engineering (ACS Publications) China, 13 June 2024

Pharmacology, Oncology

Key words: Anatomy, Cells,Genetics, Peptides and proteins, Tumors [more]

Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction between PTBP1 and ACTN4

Z Chu, M Zhu, Y Luo, Y Hu, X Feng, J Shen, H Wang, M Sunagawa, Y Liu

Journal of Pharmaceutical Analysis (Elsevier) China, Japan, 13 June 2024

Oncology, Cell Biology

Key words: Traditional Chinese Medicine, polypyrimidine domain-binding protein 1, alpha actinin-4, gastric cancer, actin skeleton remodelling [more]

Impaired gut barrier integrity and reduced colonic expression of free fatty acid receptors in patients with Parkinson's disease

PH Liao, HY Tung, WS Lim, JSJ Jang, H Li, CT Shun, HM Chiu, MS Wu, CH Lin

Neurological Sciences (Springer) Taiwan, 12 June 2024

Gastroenterology, Neuroscience

Key words: Free fatty acid receptor, Short-chain fatty acid, Leaky gut, Tight junction, Parkinson’s disease [more]

A Lactobacillus Combination Ameliorates Lung Inflammation in an Elastase/LPS—induced Mouse Model of Chronic Obstructive Pulmonary Disease

HT Shen, YT Fang, WH Tsai, CH Chou, MS Huang, YT Yeh, JT Wu, CH Huang, BY Wang, WW Chang

Probiotics and Antimicrobial Proteins (Springer) Taiwan, 12 June 2024

Pulmonology, Microbiology

Key words: COPD, Lactobacillus, Gut microbiota, Gut-lung axis, Short chain fatty acids [more]

Bidirectional activation of stem-like programs between metastatic cancer and alveolar type 2 cells within the niche

F Rodrigues, A Karoutas, S Ruhland, N Rabas, T Rizou, S Di Blasio, R Ferreira, V Bridgeman, R Goldstone, M Sopena, J Lee, L Ombrato, I Malanchi

Developmental Cell (Cell Press) UK, USA, 11 June 2024

Oncology, Stem Cell Research

Key words: Metastasis, metastatic niche, breast cancer, alveolar type 2 cells, multilineage state, Sox9, metastasis-initiating cells, lung stem cells, tissue reprogramming

AB0735 ALTERED GALECTIN EXPRESSION CORRELATE WITH TNF-MEDIATED INFLAMMATORY CARTILAGE DAMAGE

S Hayer, B Niederreiter, C Strauß, R Windhager, D Aletaha, S Toegel

Annals of the Rheumatic Diseases (BMJ Journals) Austria, 10 June 2024

Immunology, Chondrology

[more]

A fusion protein approach to integrate antiviral and anti-inflammatory activities for developing new therapeutics against influenza A virus infection

G Zhai, W Fu, S Yuan, P Sun, C Zhu, C Zhao, X Zhang, J Xu

Antiviral Research (Elsevier) China, 10 June 2024

Immunology

Key words: IFNα2-TFF2 fusion protein, H1N1 (PR8), Antiviral, Anti-inflammation, Mice protectivity [more]

The macrophage polarization in allergic responses induced by tropomyosin of Macrobrachium nipponense in cell and murine models

Y Xie, X Hu, X Li, P Tong, Y Zhang, S Zheng, J Zheng, X Liu, H Chen

International Immunopharmacology (Elsevier) China, USA, 10 June 2024

Immunology, Allergy Research

Key words: Macrophage, Polarization, Allergic responses, Tropomyosin, Macrobrachium nipponense [more]

Characteristics of Retinal Vascular Degeneration and the Expression of Vessel-Related Claudin Proteins in Retinal Degeneration Mouse

A Wang, J Zhou, Y Hong, Y Cui, Y Wang, J Pan, Y Wu, Y Luo

Ophthalmic Research (Karger) China, 10 June 2024

Ophthalmology

Key words: angiogenesis, vascular degeneration, claudin, retinal degeneration, retinal ganglion cell [more]

Therapeutic Effects of Engineered Exosomes from RAW264. 7 Cells Overexpressing hsa-let-7i-5p against Sepsis in Mice—A Comparative Study with Human Placenta-Derived Mesenchymal Stem Cell Exosomes

VL Le, CY Chang, CW Chuang, SH Syu, HJ Shih, HPN VO, MN Van, CJ Huang

Journal of Personalized Medicine (MDPI) Taiwan, Vietnam, 09 June 2024

Pharmacology

Key words: exosomes; hsa-let-7i-5p; Raw264.7 cells; stem cells; lung; endotoxin; mice [more]

Human platelet lysate-cultured adipose-derived stem cell sheets promote angiogenesis and accelerate wound healing via CCL5 modulation

YC Chen, EY Chuang, YK Tu, CL Hsu, NC Cheng

Stem Cell Research & Therapy (Springer) Taiwan, 09 June 2024

Pharmacology

Key words: Adipose-derived stem cells, Cell sheet, Wound healing, Angiogenesis, CCL5 [more]

OsNLP3 enhances grain weight and reduces grain chalkiness in rice

LQ Sun, Y Bai, J Wu, SJ Fan, SY Chen, ZY Zhang, JQ Xia, SM Wang, YP Wang, P Qin, SG Li, P Xu, Z Zhao, CB Xiang, ZS Zhang

Plant Communications (Cell Press) China, 08 June 2024

Agricultural Science, Genetics

Key words: OsNLP3, OsCEP6.1, OsNF-YA8, grain weight, grain chalkiness, rice, Oryza sativa L. [more]

The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants

Y Lu, Y Sun, J Zhang, M Kong, Z Zhao, B Sun, Y Wang, Y Jiang, S Chen, C Wang, Y Tong, L Wen, M Huang, F Wu, L Zhang

Cancer Letters (Elsevier) China, 06 June 2024

Oncology, Immunology

Key words: USP2a, B7–H4, EGFR MT, Deubiquitination, Tumor immunosuppression [more]

Integrating bulk and single-cell sequencing reveals metastasis-associated CAFs in head and neck squamous cell carcinoma

Y Yao, G Tian, J Zhang, S Zhang, X Liu, J Hou

Life Sciences (Elsevier) China, 06 June 2024

Oncology

Key words: HNSCC, Cancer-associated fibroblasts, Metastasis, TIMP1 [more]

Celastrol reduces lung inflammation induced by multiwalled carbon nanotubes in mice via NF-κb-signaling pathway

TL Qing, XY Jiang, JF Li, Q Shen, XY Zhao, LJ Ren, XY Dai, JQZ Zhang, WJ Shi, XF Zhang, B Zhang, L Yan, JK Chen, JB Zhu

Inhalation Toxicology (Taylor &Francis) China, 05 June 2024

Immunology, Nanomedicine

Key words: Celastrol, multiwalled carbon nanotubes, inflammation, NF-κB-signaling pathway [more]

Extrusion of Neutrophil Extracellular Traps (NETs) Negatively Impacts Canine Sperm Functions: Implications in Reproductive Failure

M León, C Moya, RC Rivera-Concha, F Pezo, P Uribe, M Schulz, R Sánchez, A Taubert, C Hermosilla, F Zambrano

International Journal of Molecular Science (MDPI) Chile, Germany, 05 June 2024

Reproductive Medicine

Key words: canine; spermatozoon; PMNs; neutrophil extracellular traps (NETs); sperm functionality [more]

Randomized Phase II Study Evaluating the Addition of Pembrolizumab to Radium-223 in Metastatic Castration-resistant Prostate Cancer

AD Choudhury, L Kwak, A Cheung, KM Allaire, J Marquez, DD Yang, A Tripathi, JM Kilar, M Flynn, B Maynard, R Reichel, AF Pace, BK Chen, EMV Allen, K Kilbridge, XX Wei, BA McGregor, MM Pomerantz, RS Bhatt, CJ Sweeney, GJ Bubley, HA Jacene, ME Taplin, FW Huang, LC Harshman, L Fong

Cancer Immunology Research (AACR) USA, Australia, 04 June 2024

Oncology

[more]

Pyroptosis and mitochondrial function participated in miR-654-3p-protected against myocardial infarction

C Wu, XC Zhang, LR Chen, HZ Huang, WY Wu, Y Wang, G Li

Cell Death & Disease (Nature) China, 04 June 2024

Cardiology

Key words: Myocardial infarction, Translational research [more]

PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation

VC Ribeiro, LC Russo, NC Hoch

The EMBO Journal (EMBOpress) Brazil, 04 June 2024

Virology

[more]

Oxymatrine and Gut Microbiota Modulation: A Potential Therapeutic Strategy for Bone Cancer Pain Management

Z Liu, H Chen, X Ning, J Li, L Pan

The Journal of Pain (Elsevier) China, 04 June 2024

Pharmacology, Oncology

Key words: Bone Cancer Pain, Gut Microbiota, Clostridium butyricum, Nab, OMT, PPAR gamma [more]

Predictive model based on multiple immunofluorescence quantitative analysis for pathological complete response to neoadjuvant immunochemotherapy in lung squamous cell carcinoma

M Xiao, L Tu, T Zhou, Y He, X Li, Q Zuo

Frontiers in Oncology (Frontiers Media S.A.) China, 03 June 2024

Oncology, Immunology

Key words: lung squamous cell carcinoma, neoadjuvant immunochemotherapy, pathological complete response, predictive model, multiple immunofluorescence quantitative analysis [more]

IL-6 inhibition prevents costimulation blockade-resistant allograft rejection in T cell-depleted recipients by promoting intragraft immune regulation in mice

M Muckenhuber, K Mengrelis, AM Weijler, R Steiner, V Kainz, M Buresch, H Regele, S Derdak, A Kubetz, T Wekerle

Nature Communications (Nature) Austria, 03 June 2024

Immunology

Key words: Allotransplantation, Translational immunology [more]

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

B Do, P Hsu, S Vermeulen, Z Wang, T Hirz, K Abbott, N Aziz, J Replogle, S Bjelosevic, J Paolino, S Nelson, S Block, A Darnell, R Ferreira, H Zhang, J Milosevic, D Schmidt, C Chidley, I Harris, J Weissman, Y Pikman, K Stegmaier, S Cheloufi, X Su, D Sykes, M Vander Heiden

Developmental Cell (Cell Press) USA, 31 May 2024

Cell Biology, Genetics

Key words: replication, cancer, differentiation, epigenetics, cell state, replication stress, nucleotides, dependencies, metabolism, hematopoiesis, cell fate [more]

Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma

D Gu, X Zhao, J Song, J Xiao, L Zhang, G Deng, D Li

Frontiers in Immunology (Frontiers) China, 31 May 2024

Oncology

Key words: cholangiocarcinoma, multiplex immunofluorescence, carcinogenesis, prognosis, IL-6/STAT3 pathway, tissue microarray [more]

A novel exosome-based multifunctional nanocomposite platform driven by photothermal-controlled release system for repair of skin injury

X Teng, T Liu, G Zhao, Y Liang, P Li, F Li, Q Li, J Fu, C Zhong, X Zou, L Li, L Qi

Journal of Controlled Release (Elsevier) China, 31 May 2024

Nanomedicine, Regenerative Medicine

Key words: Exosomes, Hydrogel, Ti3C2, Photothermal, Controlled release, Skin injury [more]

Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression

Z Liang, Z Tang, C Zhu, F Li, S Chen, X Han, R Zheng, X Hu, R Lin, Q Pei, C Yin, J Wang, C Tang, N Cao, J Zhao, R Wang, X Li, N Luo, Q Wen, J Yu, J Li, X Xia, X Zheng, X Wang, N Huang, Z Zhong, C Mo, P Chen, Y Wang, J Fan, Y Guo, H Zhong, J Liu, Z Peng, H Mao, G Shi, J Bonventre, W Chen, Y Zhou

Immunity (Cell Press) China, USA, 29 May 2024

Immunology, Nephrology

Key words: renal fibrosis, group 3 innate lymphoid cells, gut-kidney axis, programmed death receptor-1 [more]

Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis

G Tomić, C Sheridan, AY Refermat, MP Baggelaar, J Sipthorp, B Sudarshan, CA Ocasio, A Suárez-Bonnet, SL Priestnall, E Herbert, EW Tate

Cell Reports (Cell Press) UK, The Netherlands, 28 May 2024

Oncology

[more]

Longer prostate stromal cell telomere length is associated with increased risk of death from other cancers

JO Mori, EA Platz, J Lu, A Brame, M Han, CE Joshu, AMD Marzo, AK Meeker, CM Heaphy

Frontiers in Medicine (Frontiers) USA, 28 May 2024

Oncology

Key words: cancer, mortality, prostate cancer, stromal cells, telomeres [more]

Liquid foam improves potency and safety of gene therapy vectors

K Fitzgerald, SB Stephan, N Ma, QV Wu, MT Stephan

Nature Communications (Nature) USA, 28 May 2024

Pharmacology, Biomaterials

Key words: Biomedical materials, Gene therapy, Genetic transduction, Genetic vectors [more]

PAK2 promotes proliferation, migration, and invasion of lung squamous cell carcinoma through LIMK1/cofilin signaling pathway

C Wang, J Wang, R Xu, X Huang, Q Li, C Zhang, B Yuan

The Journal of Biomedical Research (jbr-pub.org.cn) China, 27 May 2024

Oncology, Molecular Biology

Key words: PAK2, LUSC, LIMK1, cofilin [more]

Spatial transcriptomic brain imaging reveals the effects of immunomodulation therapy on specific regional brain cells in a mouse dementia model

EJ Lee, M Suh, H Choi, Y Choi, DW Hwang, S Bae, DS Lee

BMC genomics (Springer) South Korea, 25 May 2024

Neuroscience, Immunology

Key words: Spatial transcriptomics, Brain imaging, Cell type decomposition, Cell state annotation, Major brain cells, Rare immune cells, Immunomodulatory therapy [more]

Determining the optimal distal resection margin in rectal cancer patients by imaging of large pathological sections: An experimental study

S Lin, J Wei, H Lai, Y Zhu, H Gong, C Wei, B Wei, Y Luo, Y Liu, X Mo, H Zuo, Y Lin

Medicine (Wolters Kluwer) China, 24 May 2024

Oncology

[more]

Triptolide exposure triggers testicular vacuolization injury by disrupting the Sertoli cell junction and cytoskeletal organization via the AKT/mTOR signaling pathway

X Yang, L He, X Li, L Wang, T Bu, D Yun, X Lu, S Gao, Q Huang, J Li, B Zheng, J Yu, F Sun

Ecotoxicology and Environmental Safety (Elsevier) China, 23 May 2024

Reproductive Medicine

Key words: , esticular vacuolization injury, BTB integrity, Cytoskeleton, AKT/mTOR signaling [more]

Neuroprotection effects of kynurenic acid-loaded micelles for the Parkinson's disease models

CM Chen, CY Huang, CH Lai, YC Chen, YT Chen, YT Hwang, CY Lin

Journal of Liposome Research (Taylor &Francis) Taiwan, 23 May 2024

Nanomedicine, Neuroscience

Key words: Kynurenic acid, kynurenic acid-loaded micelles, nanoparticles, neuroprotection, Parkinson’s disease [more]

Label Free Assessment of Key Biological Autofluorophores: Material Characteristics and Opportunities for Clinical Applications

JM Campbell, M Gosnell, A Agha, S Handley, A Knab, AG Anwer, A Bhargava, EM Goldys

Advanced Materials (Wiley) Australia, 22 May 2024

Bioimaging

[more]

Multiomics integration reveals NETosis heterogeneity and TLR2 as a prognostic biomarker in pancreatic cancer

Y Fu, J Tao, Y Gu, Y Liu, J Qiu, D Su, R Wang,W Luo, T Liu, F Zhang, T Zhang, Y Zhao

NPJ Precision Oncology (Nature) China, UK, 20 May 2024

Oncology

[more]

TCL1A-expressing B cells are critical for tertiary lymphoid structure formation and the prognosis of oral squamous cell carcinoma

W Xie, J Lu, Y Chen, X Wang, H Lu, Q Li, N Jin, J He, L Ou, J Ni, Y Shen, L Shao

Journal of Translational Medicine (Springer) China, 19 May 2024

Oncology

Key words: B cells, Tertiary lymphoid structures, Oral squamous cell carcinoma, TCL1A [more]

Insights into the effects of chronic combined chromium-nickel exposure on colon damage in mice through transcriptomic analysis and in vitro gastrointestinal digestion assay

S Zheng, Z Wang, X Cao, L Wang, X Gao, Y Shen, J Du, P Liu, Y Zhuang, X Guo

Ecotoxicology and Environmental Safety (Elsevier) China, 17 May 2024

Gastroenterology

Key words: Goblet cell; In vitro gastrointestinal digestion; Intestinal inflammation; RNA-seq; Tight junction. [more]

Prohibitin 2 deficiency in photoreceptors leads to progressive Retinal Degeneration and facilitated Müller glia engulfing microglia debris

H Zuo, W Han, K Wu, H Yang, H Song, Z Zhang, Y Lai, Z Pan, W Li, L Zhao

Experimental Eye Research (Elsevier) China, 17 May 2024

Ophthalmology

Key words: Microglia; Müller glia; Phagocytosis; Phb2; Photoreceptor; Progressive retinal degeneration. [more]

Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network

S Amemori, AM Graybiel, K Amemori

Nature Communications (Nature) Japan, USA, 17 May 2024

Neuroscience

Key words: Cognitive control, Limbic system, Motivation, Prefrontal cortex [more]

Prenatal 1‐Nitropyrene Exposure Causes Autism‐Like Behavior Partially by Altering DNA Hydroxymethylation in Developing Brain

T Zhao, CQ Huang, YH Zhang, YY Zhu, XX Chen, T Wang, J Shao, XH Meng, Y Huang, H Wang, HL Wang, B Wang, DX Xu

Advanced Science (Wiley) China, 16 May 2024

Neuroscience

[more]

Picornavirus VP3 protein induces autophagy through the TP53-BAD-BAX axis to promote viral replication

R Mao, Z Zhu, F Yang, D Sun, X Zhou, W Cao, X Qin, W Dang, H Liu, H Tian, K Zhang, Q Wu, X Liu, H Zheng

Autophagy (Taylor & Francis) China, 16 May 2024

Virology, Molecular Biology

Key words: Autophagy, picornavirus, replication, TP53-BAD-BAX axis, VP3 [more]

ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection

LE Bazzone, J Zhu, M King, G Liu, Z Guo, CR MacKay, PP Kyawe, N Qaisar, JQ Rojas-Quintero, CA Owen, AL Brass, W McDougall, CE Baer, T Cashman, CM Trivedi, MU Gack, RW Finberg, EA Kurt-Jones

Nature Communications (Nature) USA, 16 May 2024

Virology

Key words: Innate immunity, Viral host response, Viral infection [more]

Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways

Y Yan, S Bai, H Han, J Dai, L Niu, H Wang, Q Dong, H Yin, G Yuan, Y Pan

Cell Communication and Signaling (Springer) China, 15 May 2024

Oncology

Key words: Glioma, Glioblastoma, Microglia, Trem2 protein, Stat1 protein, Microglial polarization [more]

Building momentum through networks: Bioimaging across the Americas

M De Niz, R Escobedo García, C Terán Ramirez, Y Pakowski, Y Abonza, N Bialy, VL Orr, A Olivera, V Abonza, K Alleva, S Allodi, MF Almeida, AR Becerril Cuevas, F Bonnet, A Burgos Solorio, TL Chew, G Chiabrando, B Cimini, A Cleret Buhot, G Contreras Jiménez, L Daza, V De Sá, N De Val, DL Delgado Álvarez, K Eliceiri, R Fiolka, H Grecco, D Hanein, P Hernández Herrera, P Hockberger, HO Hernandez, Y Hernández Guadarrama, M Itano, CA Jacobs, LF Jiménez García, V Jiménez Sabinina, A Kamaid, A Keppler, A Kumar, J Lacoste, A Lovy, K Luby Phelps, A Mahadevan Jansen, L Malacrida, SB Mehta, C Miller, K Miranda, JA Moore, A North, P O'Toole, M Olivares Urbano, LI Pietrasanta, RV Portugal, AH Rossi, J Sanch

Journal of Microscopy (Wiley) USA, Mexico, Uruguay, Argentina, Canada, Colombia, South Africa, Brazil, Chile, Germany, UK, 15 May 2024

Bioimaging

Key words: bioimaging networks, BioImaging North America, community-building, imaging scientists, Latin America Bioimaging

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

C Hromada, P Heimel, M Kerbl, L Gál, S Nürnberger, B Schaedl, J Ferguson, N Swiadek, X Monforte, JC Heinzel, A Nógrádi, AH Teuschl-Woller, D Hercher

Neural Regeneration Research (Wolters Kluwer) Austria, Hungary, Germany, 13 May 2024

Neuroscience

[more]

Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function

HW Lee, SJ Chen, KJ Tsai, KS Hsu, YF Chen, CH Chang, HH Lin, WY Hsueh, HP Hsieh, YF Lee, HC Chiang, JY Chang

Journal of biomedical science (Springer) Taiwan, 09 May 2024

Neuroscience, Molecular Biology

Key words: Cathepsin S, Cognitive function, OLF-1, Brain-derived neurotrophic factor [more]

Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury

J Nehme, L Mesilmany, M VarelaEirin, S Brandenburg, A Altulea, Y Lin, M Gaya da Costa, M Seelen, J Hillebrands, H van Goor, R Saab, H Akl, N Prevarskaya, V Farfariello, M Demaria

Nature Aging (Nature) The Netherlands, Lebanon, France, USA, 09 May 2024

Aging, Regenerative Medicine

Key words: Aging, Senescence

Receptor Ligand-Free Mesoporous Silica Nanoparticles: A Streamlined Strategy for Targeted Drug Delivery across the Blood–Brain Barrier

Z Chen, C Wu, S Wu, C Huang, C Mou, K Wei, Y Yen, I Chien, S Runa, Y Chen, P Chen

ACS Nano (ACS Publications) Taiwan, USA, 08 May 2024

Nanomedicine, Pharmacology

[more]

Comprehensive Analysis of the Immunosuppressive Function of Regulatory T Cells in Human Hepatocellular Carcinoma Tissues

J Ge, J Chen, Q Shen, X Zheng, X Chen, L Shi, L Chen, B Xu

Cancer Control (Sage Journals) China, 07 May 2024

Oncology

Key words: hepatocellular carcinoma; multicolor immunohistochemistry; prognosis; regulatory T cells; tumor microenvironment [more]

H3K27Me3 abundance increases fibrogenesis during endothelial-to-mesenchymal transition via the silencing of microRNA-29c

J Fledderus, L Brouwer, T Kuiper, MC Harmsen, G Krenning

Frontiers in Cardivascular Medicine (Frontiers) The Netherlands, 07 May 2024

Cardiology

Key words: EZH2, H3K27Me3, EndMT, miR-29c, fibrogenesis [more]

Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF-κB pathways

L Liang, J Zhang, J Chen, Y Tian, W Li, M Shi, S Cheng, Y Zheng, C Wang, H Liu, X Yang, W Ye

European Journal of Pharmacology (Elsevier) China, 03 May 2024

Gastroenterology, Immunology

Key words: Colitis, Bazedoxifene, Gut microbiota, STAT3, NF-κB [more]

Alkaloids in Uncaria rhynchophylla improves AD pathology by restraining CD4+ T cell-mediated neuroinflammation via inhibition of glycolysis in APP/PS1 mice

Y Kuang, M Zhu, H Gu, Y Tao, H Huang, L Chen

Journal of Ethnopharmacology (Elsevier) China, 03 May 2024

Pharmacology, Immunology

Key words: Alzheimer's disease, Uncaria rhynchophylla, Neuroinflammation, CD4+ T cell, Glycolysis [more]

A non-image-forming visual circuit mediates the innate fear of heights in male mice

W Shang, S Xie, W Feng, Z Li, J Jia, X Cao, Y Shen, J Li, H Shi, Y Gu, SJ Weng, L Lin, Y Pan, XB Yuan

Nature Communications (Nature) China, 03 May 2024

Neuroscience

Key words: Emotion, Neural circuits [more]

A novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer

W Lin, C Chang, J Pan, F Lin, Y Chen, Y Chen, P Wang, W Hong, S Chen, C Lin, Y Kuo, W Chung, H Cheng, M Hsiao, C Yang, P Lu

Cell Death & Disease (Nature) Taiwan, 02 May 2024

Oncology, Genetics

Key words: Breast cancer, Cell invasion [more]

PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis

L Zhang, F Nie, J Zhao, S Li, W Liu, H Guo, P Yang

Journal of Translational Medicine (Springer) China, USA, 30 April 2024

Immunology

Key words: PGRN, Macrophage polarization, TNFR2, Periodontitis, Multiple fluorescence immunohistochemistry [more]

Prognostic and Immunotherapeutic Predictive Value of CAD Gene in Hepatocellular Carcinoma: Integrated Bioinformatics and Experimental Analysis

X Wang, JK Feng, FF Mao, YC Hou, YQ Zhang, LH Liu, Q Wei, JX Sun, C Liu, J Shi, SQ Cheng

Molecular Biotechnology (Springer) China, 29 April 2024

Oncology

Key words: CAD, Hepatocellular carcinoma (HCC), TCGA, Prognosis, Immune therapy [more]

Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism

S Madai, P Kilic, RM Schmidt, C BasOrth, T Korff, M Büttner, G Klinke, G Poschet, HH Marti, R Kunze

Theranostics (Ivyspring) Germany, 29 April 2024

Neuroscience, Metabolism

Key words: HIF, PHD, Roxadustat, ischemic stroke, metabolic reprogramming, aerobic glycolysis [more]

L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury

W Wang, J Zhao, Z Li, X Kang, T Li, N Isaev, E Smirnova, H Shen, L Liu, Y Yu

Biomedicine & Pharmacotherapy (Elsevier) China, Russia, 27 April 2024

Neuroscience, Metabolism

Key words: L-DOPA, GCI/R, Dopamine, Hippocampus, Mitochondria, Respiratory metabolism [more]

Polystyrene microplastics enhance microcystin-LR-induced cardiovascular toxicity and oxidative stress in zebrafish embryos

Y Xiao, L Hu, J Duan, H Che, W Wang, Y Yuan, J Xu, D Chen, S Zhao

Environmental Pollution (Elsevier) China, 26 April 2024

Toxicology, Cardiology

Key words: Microcystin-LR, Polystyrene-MPs/NPs, Cardiovascular toxicity, Calcium, Inflammation, Oxidative stress [more]

Modulation of epithelial-mesenchymal transition by gemcitabine: Targeting ionizing radiation-induced cellular senescence in lung cancer cell

H Zhou, C Li, Y Ren, W Wang, J Zhuang, Y Ren, L Shen, Y Chen

Biochemical Pharmacology (Elsevier) China, 25 April 2024

Oncology

Key words: Epithelial-Mesenchymal Transition, Gemcitabine, Ionizing Radiation, Cellular Senescence, TGFβ/SMAD, Lung Cancer Cell [more]

Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells

W Dai, B Xu, L Ding, Z Zhang, H Yang, T He, L Liu, X Pei, X Fu

Free Radical Biology and Medicine (Elsevier) China, 25 April 2024

Stem Cell Research, Reproductive Medicine

Key words: Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), Premature ovarian insufficiency, Ovarian granulosa cells, Ferritinophagy, Ferroptosis, Nuclear factor erythroid 2-related factor 2 (NRF2) [more]

To develop a prognostic model for neoadjuvant immunochemotherapy efficacy in esophageal squamous cell carcinoma by analyzing the immune microenvironment

Z Yehan, Q Sheng, Y Hong, L Jiayu, H Jun, J Juan, S Min, Y Jiaxin, H Shangzhi, W Yi, W Qifeng, L Xuefeng, H Wenwu, C Xueyan, L Yang, H Zongyao

Frontiers in Immunology (Frontiers) China, 25 April 2024

Oncology, Immunology

Key words: esophageal squamous cell carcinoma (ESCC); neoadjuvant immunochemotherapy (NICT); predictive model; response; tumor immune microenvironment (TIME). [more]

Oncolytic adenovirus in treating malignant ascites: A phase II trial and longitudinal single-cell study

Y Zhang, L Qian, K Chen, S Gu, Z Meng, J Wang, Y Li, P Wang

Molecular Therapy (Cell Press) China, 23 April 2024

Oncology, Virology

Key words: oncolytic virus, malignant ascites, clinical trial, single-cell sequencing [more]

Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity

J Hu, H Xu, T Wu, C Zhang, H Shen, R Dong, Q Hu, Q Xiang, S Chai, G Luo, X Chen, Y Huang, X Zhao, C Peng, X Wu, B Lin, Y Zhang, Y Xu

Journal of Medicinal Chemistry (ACS Publications) China, 22 April 2024

Oncology, Pharmacology

Key words: Assays, Degradation, Inhibitors, Peptides and proteins, Phenyls

Absence of E2f1 Negates Pro-osteogenic Impacts of p21 Absence

P Premnath, T Lun, H Siddiqui, AR Stahl, AA Ardebili, A Olsen, R Krawetz

Calcified Tissue International (Springer) USA, Canada, 21 April 2024

Osteology

Key words: Bone healing, Cell cycle regulation, p21, E2f1, Osteogenesis, Use our pre-submission checklist, Avoid common mistakes on your manuscript [more]

Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model

M Ahmed, LB Tezera, N Herbert, M Chambers, MT Reichmann, K Nargan, H Kloverpris, F Karim, M Hlatshwayo, R Madensein, M Habesh, M Hoque, AJC Steyn, PT Elkington, AJ Leslie

Frontiers in Immunology (Frontiers) South Africa, UK, Denmark, USA, 20 April 2024

Immunology

Key words: CD200 receptor; immune checkpoint; innate immunity; pulmonary infection; tuberculosis [more]

Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization

W Wang, T Li, Y Cheng, F Li, S Qi, M Mao, J Wu, Q Liu, X Zhang, X Li, L Zhang, H Qi, L Yang, K Yang, Z He, S Ding, Z Qin, Y Yang, X Yang, C Luo, Y Guo, C Wang, X Liu, L Zhou, Y Liu, W Kong, J Miao, S Ye, M Luo, L An, L Wang, L Che, Q Niu, Q Ma, X Zhang, Z Zhang, R Hu, H Feng, Y Ping, X Bian, Y Shi

Cancer Cell (Cell Press) China, 18 April 2024

Oncology, Immunology

Key words: glioma, glioblastoma, tumor-associated macrophages, hypoxia, necrosis, vasculature normalization, single-cell transcriptomics, adrenomedullin, spatial transcriptomics, dabrafenib [more]

Efficacy and biomarker analysis of second‐line nab‐paclitaxel plus sintilimab in patients with advanced biliary tract cancer

X Li, N Zhou, Y Yang, Z Lu, H Gou

Cancer Science (Wiley) China, 18 April 2024

Oncology

[more]

ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance

CJ Lee, H Lee, SR Kim, SB Nam, GE Lee, KE Yang, GJ Lee, SH Chun, HC Kang, JY Lee, HS Lee, SJ Cho, YY Cho

Cell Death & Disease (Nature) South Korea, USA, 17 April 2024

Oncology

Key words: Oncogenesis, Ubiquitylation [more]

Spatiotemporal architecture of immune cells and cancer-associated fibroblasts in high-grade serous ovarian carcinoma

AM Xu, M Haro, AE Walts, Y Hu, J John, BY Karlan, A Merchant, S Orsulic

Science Advances (Science) USA, 17 April 2024

Oncology, Immunology

[more]

Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment

NK Horvat, S Chocarro, O Marques, TA Bauer, R Qiu, AJ Diaz-Jimenez, B Helm, Y Chen, S Sawall, R Sparla, L Su, U Klingmüller, M Barz, MW Hentze, R Sotillo, MU Muckenthaler

ACS Nano (ACS Publications) Germany, The Netherlands, 16 April 2024

Oncology

Key words: iron homeostasis, nanoparticle, polymeric miceclle, lung cancer, adjuvant therapy [more]

In vivo SPECT imaging of Tc-99 m radiolabeled exosomes from human umbilical-cord derived mesenchymal stem cells in small animals

YH Chung, YP Ho, SS Farn, WC Tsai, ZX Li, TY Lin, CC Wenig

Biomedical Journal (Elsevier) Taiwan, 16 April 2024

Pharmacology

Key words: Tc-99, USMSC-Evs, SPECT, Biodistribution, Pharmacokinetic analyses [more]

Coronary Microvascular Dysfunction in Acute Cholestasis-Induced Liver Injury

S Billig, M Hein, C Kirchner, D Schumacher, MA Habigt, M Mechelinck, D Fuchs, U Klinge, A Theißen, C Beckers, C Bleilevens, R Kramann, M Uhlig

Biomedicines (MDPI) Germany, The Netherlands, 16 April 2024

Hepathology

Key words: acute cholestatic liver injury; cardiac function; liver–heart axis; rodent model; coronary microvascular dysfunction; myocardial contrast echocardiography; coronary flow velocity reserve [more]

Versatile tissue‐injectable hydrogels capable of the extended hydrolytic release of bioactive protein therapeutics

ES Nealy, SJ Reed, SM Adelmund, BA Badeau, JA Shadish, EJ Girard, K Brasel, FJ Pakiam, AJ Mhyre, JP Price, S Sarkar, V Kalia, CA DeForest, JM Olson

Bioengineering & Translational Medicine (Wiley) USA, 15 April 2024

Biomaterials, Pharmacology

Key words: drug delivery, extended release, hydrogels, immuno-oncology, loco-regional, proteins, sortase [more]

Th17 cells secrete TWEAK to trigger epithelial-mesenchymal transition and promote colorectal cancer liver metastasis

X Liu, X Wang, Q Yang, L Luo, Z Liu, X Ren, K Lei, S Li, Z Xie, G Zheng, Y Zhang, Y Hao, Q Zhou, Y Hou, F Fang, W Song, J Cui, J Ma, W Xie, S Shen, C Tang, S Peng, J Yu, M Kuang, X Song, F Wang, L Xu

Cancer Research (AACR) China, 15 April 2024

Oncology

[more]

Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer

H Hu, H Zhu, W Zhan, B Hao, T Yan, J Zhang, S Wang, X Xu, T Zhang

Inflammation Research (Springer) China, 15 April 2024

Oncology

Key words: Breast cancer, CD24, CD8+ T cell, Tumor immune microenvironment, Immunotherapy [more]

Vaginal Microbiota and Proinflammatory Status in Patients with Polycystic Ovary Syndrome: An Exploratory Study

ME Espinosa, A Melo, M Leon, EV Bautista-Valarezo, F Zambrano, P Uribe, A Bravo, A Taubert, C Hermosilla, V Iturrieta, R Sánchez

Journal of Clinical Medicine (MDPI) Chile, Ecuador, Germany, 15 April 2024

Gynaecology

Key words: polycystic ovary syndrome; phenotypes; vaginal inflammatory reaction; vaginal microbiota; neutrophil extracellular traps (NETs) [more]

Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice

X Wang, Y Jin, C Di, Y Zeng, Y Zhou, Y Chen, Z Pan, Z Li, W Ling

Nutrients (MDPI) China, 14 April 2024

Nutritional science

Key words: dietary silymarin intervention; NAFLD; gut microbiota; fecal microbiome transplantation (FMT); bile acids; secondary bile acids; metabolomics analysis [more]

A novel perspective on di-hexyl phthalate (2-ethylhexyl)-induced reproductive toxicity in females: Lipopolysaccharide synergizes with mono-2-ethylhexyl ester to cause inflammatory apoptosis rather than autophagy in ovarian granulosa cells

B Xu, Z Zhang, H Yang, L Ding, W Dai, L Liu, X Du, X Fu, X Pei

Ecotoxicology and Environmental Safety (Elsevier) China, 13 April 2024

Reproductive Medicine

Key words: Apoptosis; Autophagy; Di-hexyl phthalate (2-ethylhexyl); Inflammation; NF-κB pathway; Ovarian Granulosa Cells [more]

Macrophage-coated tumor cluster aggravates hepatoma invasion and immunotherapy resistance via generating local immune deprivation

J Ning, Y Ye, H Shen, R Zhang, H Li, T Song, R Zhang, P Liu, G Chen, H Wang, F Zang, X Li, J Yu

Cell Reports Medicine (Cell Press) China, 12 April 2024

Oncology, Immunology

Key words: M2BP; T cell exclusion; hepatocellular carcinoma; immune checkpoint inhibitors; immunological evasion; macrophages coated tumor cluster; tumor-associated macrophages [more]

Combined therapy of dabrafenib and an anti-HER2 antibody–drug conjugate for advanced BRAF-mutant melanoma

W Li, C Zheng, X Xu, Y Xia, K Zhang, A Huang, X Zhang, Y Zheng, G Chen, S Zhang

Cellular &Molecular Biology Letters (Springer) China, 10 April 2024

Oncology, Dermatology

Key words: HER2, RC48, Antibody drug conjugate, Dabrafenib, Synergetic effect, Melanoma [more]

Identification of neutrophils and eosinophils in upper airway mucosa with immunofluorescence multiplex image cytometry

AI Giotakis, J Dudas, R Glueckert, E Buechel, H Riechelmann

Histochemistry and Cell Biology (Springer) Austria, 10 April 2024

Immunology, Bioimaging

Key words: Image cytometry, Fluorescent antibody technique, Sinusitis, Leukocytes, Neutrophils, Eosinophils [more]

The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation

AR Murphy, H Asif, H Cingoz, FA Gourronc, JA Ankrum, AJ Klingelhutz, JJ Kim

The Journal of Clinical Endocrinology & Metabolism (Oxford Academic) USA, 10 April 2024

Physiology

Key words: endometrium, obesity, adiposity, metallothionein, progesterone [more]

Prognostic value of CD8+T cells related genes and exhaustion regulation of Notch signaling pathway in hepatocellular carcinoma

Q Pu, L Yu, X Liu, H Yan, Y Xie, X Cai, Y Wu, J Du, Z Yang

Frontiers in Immunology (Frontiers) China, 08 April 2024

Oncology

Key words: hepatocellular carcinoma, CD8+T cells exhaustion, risk scoring, prognosis, Notch signaling pathway [more]

MCP-1 controls IL-17-promoted monocyte migration and M1 polarization in osteoarthritis

SL Hsieh, SY Yang, CY Lin, XY He, CH Tsai, YC Fong, YS Lo, CH Tang

International Immunopharmacology (Elsevier) Taiwan, 08 April 2024

Osteology, Immunology

Key words: IL-17; M1 polarization; MCP-1; Monocyte; Osteoarthritis. [more]

Alkali injury–induced pathological lymphangiogenesis in the iris facilitates the infiltration of T cells and ocular inflammation

Z Liu, K Liu, S Shi, X Chen, X Gu, W Wang, K Mao, R Yibulayi, W Wu, L Zeng, W Zhou, X Lin, F Zhang, B Lou

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 08 April 2024

Immunology, Ophthalmology

Key words: Immunology; Lymph; Ophthalmology; Retinopathy; T cells. [more]

Continuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains

S Feng, T Zhang, Z He, W Zhang, Y Chen, C Yue, N Jing

Cell Regeneration (Springer) China, 07 April 2024

Neuroscience

Key words: Cell transplantation; Human induced neural stem/progenitor cells (iNPCs); Immune response; Non-human primate brain; Xenograft [more]

Integrated analysis of scRNA-seq and bulk RNA-seq reveals that GPRC5A is an important prognostic gene in pancreatic cancer and is associated with B-cell Infiltration in pancreatic cancer

C Dong, H Ma, N Mi, W Fu, J Yi, L Gao, H Wang, Y Ren, Y Lin, F Han, Z Chen, W Zhou

Frontiers in Oncology (Frontiers) China, 03 April 2024

Oncology

Key words: pancreatic cancer, single-cell, immune infiltration, B cell, Gprc5a [more]

A potential bivalent mRNA vaccine candidate protects against both RSV and SARS-CoV-2 infections

N Wu, J Zhang, Y Shen, X Zhang, J Zhou, Y Wu, E Li, X Meng, X Chuai, S Chiu, Y Wang

Molecular Therapy (Cell Press) China, 03 April 2024

Virology

Key words: antigen competition; bivalent vaccine; lipid nanoparticle; mRNA; respiratory infectious disease; respiratory syncytial virus; severe acute respiratory syndrome coronavirus 2. [more]

Shenyu ningshen tablet reduced neuronal damage in the hippocampus of chronic restraint stress model rat by inhibiting A1-reactive astrocytes

Y Wang, S Li, M Chen, M Zeng, L Zhou, R Yao, B Pang, Y Xu, S Cao, S Guo, X Cui

Heliyon (Cell Press) China, 02 April 2024

Neuroscience

Key words: A1 astrocyte; CRS rat model; Depression; Neuron; SYNS tablet [more]

Abrus cantoniensis Hance alleviates APAP-triggered acute liver damage via inhibiting the MAPK and NF-κB signaling pathways in mice

C Zhang, H Gu, C Tu, Y Yang, D Miao, L Chen

Journal of Functional Foods (Elsevier) China, 02 April 2024

Nutritional science

Key words: Abrus cantoniensis Hance, Hepatoprotective, APAP, Oxidative stress, MAPK, NF-κB [more]

A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response

H Yang, X Wu, X Li, W Zang, Z Zhou, Y Zhou, W Cui, Y Kou, L Wang, A Hu, L Wu, Z Yin, Q Chen, Y Chen, Z Huang, Y Wang, B Gu

Nature Communications (Nature) China, 02 April 2024

Immunology

Key words: Antimicrobal responses, Bacterial host response, Interleukins, Parasite host response, T-helper 1 cells [more]

Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells

C Bangert, N Alkon, S Chennareddy, T Arnoldner, JP Levine, M Pilz, MA Medjimorec, J Ruggiero, ER Cohenour, C Jonak, W Damsky, J Griss, PM Brunner

Nature Communications (Nature) Austria, USA, 02 April 2024

Dermatology

Key words: Adaptive immunity, Gene regulation in immune cells, Interleukins, Mucosal immunology, Translational research [more]

Modified Goldner Trichrome for Non-decalcified Mineralized Tissue Plastinated and Embedded in Resin

C Panes, N Ponce, NE Ottone, I ValdiviaGandur, V Beltrán, B Vásquez

International Journal of Morphology (Chilean Society of Anatomy) Chile, 01 April 2024

Histology, Tissue Engineering

Key words: Trichrome staining; Plastic resins; Hard Tissue histology. [more]

Gut microbiota-bile acid crosstalk and metabolic fatty liver in spotted seabass (Lateolabrax maculatus): The role of a cholesterol, taurine and glycine supplement

T Song, X Liang, H Wang, M Xue, J Wang

Animal Nutrition (Elsevier) China, 30 March 2024

Nutritional science

Key words: Cholesterol-taurine-glycine supplement, Plant-based diets, Fatty liver, Gut microbiota–bile acid crosstalk, Lipid metabolism [more]

Anti-osteoporotic effects of Yi Mai Jian on bone metabolism of ovariectomized rats

B Shi, CC Lin, CJ Lee, DS Ning, CC Lin, HW Zhao, CS Yang, SX Deng, YJ Chiu, CC Wang

Frontiers in Pharmacology (Frontiers) China, Taiwan, 28 March 2024

Pharmacology

Key words: anti-osteoporotic effects, Eucommiae Folium, Astragali Radix, Ligustri Lucidi Fructus, Elaeagnus Fructus, Yi Mai Jian herbal formula [more]

Modular Satellite Nanoparticles for Remedying Primary and Secondary Injury in Cerebral Ischemia‐Reperfusion

H Zhou, Y Wu, M Li, Q Liang, W Dong, Q Li, Y Wang

Advanced Functional Materials (Wiley) China, 27 March 2024

Nanomedicine, Neuroscience

[more]

DUSP3 modulates IRES‐dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus

PYM Ferruzo, VK Boell, LC Russo, CC Oliveira, FL Forti

Biology of the Cell (Wiley) Brazil, 27 March 2024

Molecular Biology

Key words: DUSP3, HNRNPC, genome integrity, mRNA translation, protein synthesis, phosphoryla-tion/dephosphorylation

Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys

PB Rupert, M Buerger, EJ Girard, M Frutoso, D Parrilla, K Ng, T Gooley, V Groh, RK Strong

Heliyon (Cell Press) USA, 27 March 2024

Immunology

Key words: Engineered biologic immunotherapeutics; NKG2D; Natural killer cell receptors; X-ray crystallography [more]

Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration

JY Ding, X Yan, RJ Zhang, HQ Zhang, L Kang, CY Jia, XY Liu, CL Shen

European Journal of Medical Research (Springer) China, 25 March 2024

Osteology

Key words: Intervertebral disc degeneration (IVDD), Cartilage oligomeric matrix protein (COMP), A disintegrin and metalloproteinases with thrombospondin motifs7 (ADAMTS7), Biomarkers, Early diagnosis [more]

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

K Baltgalvis, K Lamb, K Symons, C Wu, M Hoffman, A Snead, X Song, T Glaza, S Kikuchi, J Green, D Rogness, B Lam, M RodriguezAguirre, D Woody, C Eissler, S Rodiles, S Negron, S Bernard, E Tran, J Pollock, A Tabatabaei, V Contreras, H Williams, M Pastuszka, J Sigler, P Pettazzoni, M Rudolph, M Classen, D Brugger, C Claiborne, J Plancher, I Cuartas, J Seoane, L Burgess, R Abraham, D Weinstein, G Simon, M Patricelli, T Kinsella

Nature (Nature) USA, Switzerland, Spain, 24 March 2024

Pharmacology, Molecular Biology

Key words: Cancer, Proteomics [more]

Bioactive peptide relieves glucocorticoid-induced osteoporosis by giant macrocyclic encapsulation

Y Shang, Q Zhu, J Ding, L Zhao, F Zhang, J Lu, Y Feng, J Wang, Z Liu, M Kuang, C Li

Journal of Controlled Release (Elsevier) China, 23 March 2024

Pharmacology

Key words: Host-guest complexation; Macrocycles; Peptide; Supramolecular biomedical materials. [more]

Anti-CD36 monoclonal antibody can sensitize the neoadjuvant chemotherapy response in PDAC by eliminating the senescent tertiary lymphatic structure

J Yan, T Zhou, C Yang, Y Xie, J Yu, J Hao

Cancer Research (AACR) China, 22 March 2024

Oncology, Pharmacology

Tissue-resident cytotoxic T cell infiltration predicts metachronous colorectal cancer metastasis

R Cohen, T Lee-Pullen, T Miller, S Pirasteh, C Platell, K Meehan, K Fuller, M McCoy

Cancer Research (AACR) Australia, 22 March 2024

Oncology, Immunology

A Mechanistic and Preclinical Assessment of BioRestore Bioactive Glass as a Synthetic Bone Graft Extender and Substitute for Osteoinduction and Spine Fusion

EJ Fred, S Minardi, AM Goodwin, TS Nandurkar, MA Plantz, JG Lyons, JT Paul, JP Foley, AJ Wintring, AA Furman, S Jeong, C Yun, SR Stock, WK Hsu, EL Hsu

Clinical Spine Surgery (Lippincott Williams & Wilkins) USA, 22 March 2024

Osteology

Key words: spinal fusion, bioactive glass, bone graft extender, bone graft substitute, iliac crest bone graft, osteoinductivity [more]

Panax notoginseng saponins improve oral submucous fibrosis by inhabiting the Wnt/β-catenin signal pathway

L Hu, J He, T Zhang, S Pan, H Zou, K Lian, J Guo, T Qun

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology (Elsevier) China, 22 March 2024

Pharmacology

[more]

Effects of chronic Cr and Ni co-exposure on liver inflammation and autophagy in mice by regulating the TLR4/mTOR pathway

X Cao, S Zheng, Y Zeng, Y Shi, J Du, C Huang, Y Shen, P Liu, X Guo, X Gao

Science of The Total Environment (Elsevier) China, 22 March 2024

Toxicology

Key words: Chromium; Liver toxic effect; Mice; Nickel; TLR4/mTOR pathway. [more]

Rational evolution for altering the ligand preference of estrogen receptor alpha

R Eerlings, P Gupta, XY Lee, T Nguyen, S El Kharraz, F Handle, E Smeets, L Moris, W Devlies, B Vandewinkel, I Thiry, D Tien Ta, A Gorkovskiy, K Voordeckers, E Henckaerts, VB Pinheiro, F Claessens, KJ Verstrepen

Protein Science (Wiley) Belgium, 21 March 2024

Endocrinology

Key words: directed evolution, estrogen receptor, nuclear receptors, Saccharomyces cerevisiae, synthetic biology, tamoxifen [more]

PGR-KITLG signaling drives a tumor-mast cell regulatory feedback to modulate apoptosis of breast cancer cells

Z Yang, H Chen, S Yin, H Mo, F Chai, P Luo, Y Li, L Ma, Z Yi, Y Sun, Y Chen, J Wu, W Wang, T Yin, J Zhu, C Shi, F Zhang

Cancer Letters (Elsevier) China, 20 March 2024

Oncology

Key words: Apoptosis; Breast cancer; GRN; Mast cells; PGR-KITLG signaling. [more]

A subpopulation of luminal progenitors secretes pleiotrophin to promote angiogenesis and metastasis in inflammatory breast cancer

M Zhang, K Zhou, Z Wang, T Liu, LE Stevens, F Lynce, WY Chen, S Peng, Y Xie, D Zhai, Q Chen, Y Shi, H Shi, Z Yuan, XL 0, J Xu, Z Cai, J Guo, N Shao, Y Lin

Cancer Research (AACR) China, USA, 20 March 2024

Oncology

Key words: Inflammatory breast cancer; PTN; Luminal progenitor cell; Angiogenesis; Metastasis [more]

Inhibition of phospholipase D promotes neurological function recovery and reduces neuroinflammation after spinal cord injury in mice

H Ke, F Bai, Z Li, Y Zhu, C Zhang, Y Li, Z Talifu, Y Pan, W Liu, X Xu, F Gao, D Yang, L Du, Y Yu, J Li

Frontiers in Cellular Neuroscience (Frontiers) China, 20 March 2024

Neuroscience

Key words: neuroinflammation; phospholipase D; protein microarray analysis; spinal cord injury; transcriptome sequencing analysis [more]

Aerobic Exercise Modulates Proteomic Profiles in Gastrocnemius Muscle of db/db Mice, Ameliorating Sarcopenia

YC Huang, MR Sanotra, CC Huang, YJ Hsu, CC Liao

Life (MDPI) Taiwan, 20 March 2024

Endocrinology

Key words: aerobic exercise; db/db mice; ECM remodeling; gastrocnemius muscle; metabolic pathways; muscle regeneration; proteomic profiling; T2DM-induced sarcopenia [more]

Metabolic mechanism and pharmacological study of albendazole in secondary hepatic alveolar echinococcosis (HAE) model rats

C Li, Y Zhang, M Pang, Y Zhang, C Hu, H Fan

Antimicrobial Agents and Chemotherapy (American Society for Microbiology) China, 19 March 2024

Medical parasitology

Key words: albendazole; alveolar echinococcosis; hepatic drug-metabolizing enzyme. [more]

Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome

AJ Diaz-Jimenez, M Ramos, B Helm, S Chocarro, DL Frey, S Agrawal, K Somogyi, U Klingmüller, J Lu, R Sotillo

Drug Resistance Updates (Elsevier) Germany, 19 March 2024

Oncology

Key words: ALK, Lung Cancer, SRC, Resistance, Targeted therapy [more]

Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is suppressed by hsa-miR-200b-3p

J Shi, F Ding, D Dai, X Song, X Wu, D Yan, X Han, G Tao, W Dai

Scientific Reports (Nature) China, 19 March 2024

Oncology

Key words: Cancer. Cancer prevention, Cancer therapy, Cell growth, Cell proliferation, Gastrointestinal cancer [more]

Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer

NCW Ho, JYY Yap, Z Zhao, Y Wang, K Fernando, CH Li, XL Kwang, HS Quah, C Arcinas, NG Iyer, ELS Fong

Advanced Science (Wiley) Singapore, 17 March 2024

Oncology

Key words: CAF heterogeneity; cancer-associated fibroblasts; hydrogel; inflammatory CAF; myofibroblastic CAF [more]

Computer-assisted image analysis of preexisting histological patterns of the cephalic vein to predict wrist arteriovenous fistula non-maturation

JW Chen, M Ting, PY Chang, CJ Jung, CH Chang, SY Fang, LW Liu, KJ Yang, SH Yu, YS Chen, NH Chi, RB Hsu, CH Wang, IH Wu, HY Yu, CY Chan

Journal of the Formosan Medical Association (Elsevier) Taiwan, 16 March 2024

Medical Image Analysis

Key words: Arteriovenous fistula; Computer-assisted image interpretation; Histological technique; Vascular smooth muscle [more]

PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma

G Shu, M Chen, W Liao, L Fu, M Lin, C Gui, J Cen, J Lu, Z Chen, J Wei, W Chen, Y Wang, J Zhu, T Zhao, X Liu, J Jing, GC Liu, Y Pan, J Luo, J Zhang

Cancer Research (AACR) China, 15 March 2024

Oncology

[more]

Targeting ESE3/EHF with Nifurtimox inhibits CXCR2+ neutrophil infiltration and overcomes pancreatic cancer resistance to chemotherapy and immunotherapy

Y Xie, T Zhou, X Li, K Zhao, W Bai, X Hou, Z Liu, B Ni, Z Zhang, J Yan, Y Wang, W Jiang, H Wang, A Chang, S Gao, T Zhao, S Yang, C Huang, J Liu, J Hao

Gastroenterology (Elsevier) China, USA, 15 March 2024

Oncology, Pharmacology

Key words: CXCL1; CXCR2(+) Neutrophils; EHF; Nifurtimox; Pancreatic Cancer. [more]

YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia

Z Liu, S Li, S Chen, J Sheng, Z Li, T Lv, W Yu, Y Fan, J Wang, W Liu, S Hu, J Jin

Iscience (Cell Press) China, 15 March 2024

Urology

Key words: Biochemistry; Cell biology; Molecular biology; Prostate disease [more]

Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iPSNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice

YZ Wang, T Perez-Rosello, SN Smukowski, DJ Surmeier, JN Savas

Molecular Psychiatry (Nature) USA, 14 March 2024

Neuroscience

Key words: Biological techniques, Neuroscience [more]

Nuinsseg: a fully annotated dataset for nuclei instance segmentation in h&e-stained histological images

A Mahbod, C Polak, K Feldmann, R Khan, K Gelles, G Dorffner, R Woitek, S Hatamikia, I Ellinger

Scientific Data (Nature) Austria, 14 March 2024

Medical Image Analysis, Machine Learning

Key words: Computational moderls, Data acquisition, Data processing, Super-resolution microscopy [more]

Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

ZY Li, YQ Mao, Q Hua, YH Sun, HY Wang, XG Ye, JX Hu, YJ Wang, M Jiang

World Journal of Gastroenterology (Baishideng Publishing Group) China, 14 March 2024

Gastroenterology

Key words: Diarrhea-predominant irritable bowel syndrome, Serotonin receptor 2B, Transient receptor potential vanilloid type-1, Visceral hypersensitivity, Abdominal pain [more]

Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection

H Liu, Y Zhang, M Yip, L Ren, J Liang, X Chen, N Liu, A Du, J Wang, H Chang, H Oh, C Zhou, R Xing, M Xu, P Guo, D Gessler, J Xie, PWL Tai, G Gao, D Wang

Molecular Therapy Methods & Clinical Development (Cell Press) USA, 13 March 2024

Pharmacology

Key words: biomanufacturing; plasmid backbone; potency; rAAV; triple transfection [more]

Cytomorphological disparities in invasive breast cancer cells following neoadjuvant endocrine therapy and chemotherapy

H Hoshina, T Sakatani, Y Kawamoto, R Ohashi, H Takei

Pathobiology (Karger) Japan, 12 March 2024

Oncology

Key words: Pathological response, Morphological change, Neoadjuvant endocrine therapy, Microtubule depolymerization, Kinesin motor proteins (KIF) 2A [more]

Disorganized adrenocortical zonational structure in COVID-19 patients: Implications of critical illness duration

TZ Wen, WJ Fu, SQ Xiao, S Wang, TR Li, XY Chen, HY Chen, J Luo, XW Bian, XH Yao

Pathology -Research and Practice (Elsevier) China, 12 March 2024

Virology

Key words: Adrenal cortex; Areas of cortical zonations; COVID-19; Corticosteroid receptor; Structural disorganization [more]

Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis

S Zhang, Q Chen, M Jin, J Ren, X Sun, Z Zhang, Y Luo, X Sun

Phytomedicine (Elsevier) China, 11 March 2024

Neuroscience

Key words: Notoginsenoside R1, Ischemic stroke, Microbiota-gut-brain axis, TLR4/MyD88/NF-κB signaling pathway, Neuroinflammation, Systemic inflammation [more]

Regulation of the immune cell repertoire in psoriasis patients upon blockade of IL-17a or TNFα

J Tittes, J Brell, P Fritz, C Jonak, G Stary, JM Ressler, S Künig, W Weninger, J Stöckl

Dermatology and Therapy (Springer) Austria, 08 March 2024

Dermatology, Immunology

Key words: Psoriasis, Biologics, Immunology, T cells, Dendritic cells [more]

Cytotoxic response of tumor-infiltrating lymphocytes of head and neck cancer slice cultures under mitochondrial dysfunction

MdC Greier, A Runge, J Dudas, R Hartl, M Santer, D Dejaco, TB Steinbichler, J Federspiel, C Seifarth, M Konschake, S Sprung, S Sopper, A Randhawa, M Mayr, BG Hofauer, H Riechelmann

Frontiers in Oncology (Frontiers) Austria, USA, 07 March 2024

Oncology

Key words: cytotoxic T-cells; head and neck carcinoma; immune response; mitochondrial dysfunction; mitochondrial electron transport chain [more]

DUX4-induced HSATII transcription causes KDM2A/B–PRC1 nuclear foci and impairs DNA damage response

T Arends, H Tsuchida, RO Adeyemi, SJ Tapscott

Journal of Cell Biology (Rockerfeller University Press) USA, 07 March 2024

Molecular Biology

Key words: Chromatin or epigenetics, Development, Disease, RNA biology

Precursor exhausted CD8+T cells in colorectal cancer tissues associated with patient's survival and immunotherapy responsiveness

H Huang, J Ge, Z Fang, S Wu, H Jiang, Y Lang, J Chen, W Xiao, B Xu, Y Liu, L Chen, X Zheng, J Jiang

Frontiers in Immunology (Frontiers) China, 06 March 2024

Oncology

Key words: colorectal cancer; immunotherapy; multi-color immunohistochemistry; multi-omics; precursor exhausted CD8+T cells [more]

Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression

L Tong, X Zheng, T Wang, W Gu, T Shen, W Yuan, S Wang, S Xing, X Liu, C Zhang, C Zhang

Journal of Cellular and Molecular Medicine (Wiley) China, 06 March 2024

Oncology

Key words: autophagy, EMC6, hepatocellular carcinoma, progression, tumorigenesis, UBA52 [more]

Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury

JB Cao, ST Zhu, XS Huang, XY Wang, ML Wu, X Li, FL Liu, L Chen, YT Zheng, JH Wang

Virologica Sinica (Elsevier) China, 06 March 2024

Virology

Key words: SARS-CoV-2, Mast cell (MC), Bronchial epithelial cell, Inflammation, Tracheal injury [more]

Oleic acid induces lipogenesis and NLRP3 inflammasome activation in organotypic mouse meibomian gland and human meibomian gland epithelial cells

R Liu, M Tu, J Xue, B Xiao, J Li, L Liang

Experimental Eye Research (Elsevier) China, 05 March 2024

Ophthalmology

Key words: Oleic acid, Meibomian gland dysfunction, Lipid, NLRP3 inflammasome, AMPK [more]

Construction of an infectious clone for enterovirus A89 and mutagenesis analysis of viral infection and cell binding

J Yan, M Wang, X Li, J Fan, R Yu, M Kang, Y Zhang, J Xu, X Zhang, S Zhang

Microbiology Spectrum (American Society for Microbiology) China, 05 March 2024

Virology

Key words: enterovirus A89; infectious clone; reverse genetics; site mutations; subgenomic replicon [more]

Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression

F Khan, Y Lin, H Ali, L Pang, M Dunterman, WH Hsu, K Frenis, RG Rowe, DA Wainwright, K McCortney, LK Billingham, J Miska, C Horbinski, MS Lesniak, P Chen

Nature Communications (Nature) USA, 05 March 2024

Oncology

Key words: Cancer metabolism, Caner microenvironment, Monocytes and macrophages [more]

Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial-Mesenchymal Transition

L Fang, L Zhang, M Wang, Y He, J Yang, Z Huang, Y Tan, K Fang, J Li, Z Sun, Y Li, Y Tang, W Liang, H Cui, Q Zhu, Z Wu, Y Li, Y Hu, W Chen

Cancer Research (AACR) China, 04 March 2024

Oncology

[more]

FUSeg: The foot ulcer segmentation challenge

C Wang, A Mahbod, I Ellinger, A Galdran, S Gopalakrishnan, J Niezgoda, Z Yu

Information (MDPI) USA, Austria, UK, 01 March 2024

Bioimaging

Key words: semantic segmentation, chronic wounds, foot ulcers, wound segmentation, challenge, benchmark

Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition

YT Huang, YT Hsu, PY Wu, YM Yeh, PC Lin, KF Hsu, MR Shen

Journal of Experimental & Clinical Cancer Research (Springer) Taiwan, 01 March 2024

Oncology

Key words: Cingulin, Rac1, IQGAP1, Epithelial-mesenchymal transition, Cancer-predisposing variant [more]

Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis.

NS Dey, S Senaratne, V Somaratne, NP Madarasinghe, B Seneviratne, S Forrester, MMd Oca, LC Reis, S Moulik, PB Walrad, M Chatterjee, H Goto, R Wickremasinghe, D Lagos, PM Kaye, S Ranasinghe

The Journal of Clinical Investigation (American Society for Clinical Investigation) UK, Sri Lanka, Brazil, India, 01 March 2024

Dermatology

[more]

Nicotinamide phosphoribosyltransferase modulates PD-L1 in bladder cancer and enhances immunotherapeutic sensitivity

KC Chen, T Dhar, CR Chen, ECY Chen, CC Peng

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Taiwan, 29 February 2024

Oncology

Key words: Bladder cancer (BLCA); NAMPT (nicotinamide phosphoribosyltransferase); PD-L1 (programmed death ligand 1); Tumor microenvironment (TME). [more]

Triple‐negative breast cancer survival prediction using artificial intelligence through integrated analysis of tertiary lymphoid structures and tumor budding

X Hou, X Li, Y Han, H Xu, Y Xie, T Zhou, T Xue, X Qian, J Li, HC Wang, J Yan, X Guo, Y Liu, J Liu

Cancer (Wiley) China, 29 February 2024

Oncology

Key words: artificial intelligence, nomogram, tertiary lymphoid structures, triple-negative breast cancer, tumor budding [more]

Inhibition of P2X7R alleviates neuroinflammation and brain edema after traumatic brain injury by suppressing the NF-κB/NLRP3 inflammasome pathway

B Tao, J Pei, H Li, G Yang, X Shi, Z Zhang, H Wang, Z Zheng, Y Liu, J Zhang

Journal of Neurorestoratology (Elsevier) China, 29 February 2024

Neuroscience

Key words: Traumatic brain injury, Neuroinflammation, Brain edema, P2X7R, NF-κB, NLRP3 [more]

Immune microenvironment heterogeneity of concurrent adenocarcinoma and squamous cell carcinoma in multiple primary lung cancers

J Zhang, Y Huang, Y Han, D Dong, Y Cao, X Chen, D Liu, X Cheng, D Sun, H Li, Y Zhang

NPJ Precision Oncology (Nature) China, 29 February 2024

Oncology

Key words: Cnacer genomics, Cancer microenvironment, Non-small-cell lung cancer, Tumour immunology [more]