Logo tissuegnostics
  • INCREASE YOUR IMPACT FACTOR

    Reference Papers


  • 1

On May 3rd 2020, TissueGnostics surpassed 1,500 scientific reference publications

 Most of the 1500 research publications referencing TissueGnostics (over 50%) originated in the United States, Austria, Germany, Taiwan (China) and mainland China.

Worldmap Publications



Filter publications

Customer Publications (A total of 1683 papers published)

01
Accuracy of HPV E6/E7 mRNA examination using in situ hybridization in diagnosing cervical intraepithelial lesions

C Hui, H Bai, J Liu, X Lu, S Wang, Z Zhang, M Jin, Y Wang, Y Liu

Diagnostic Pathology (Springer) China, 19 February 2021

Pathology

Key words: Cervical intraepithelial neoplasia, CIN, Diagnostic accuracy, E6/E7 mRNA, In situ hybridization

Organism: Human

Tissue: Cervix

Pathological State: Cervical intraepithelial lesions

02
T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells

Abigail E. Schiff, Alice H. Linder, Shillah N. Luhembo, Stephanie Banning, Martin J. Deymier, Thomas J. Diefenbach, Amy K. Dickey, Athe M. Tsibris, Alejandro B. Balazs, Josalyn L. Cho, Benjamin D. Medoff, Gerhard Walzl, Robert J. Wilkinson, Wendy A. Burgers, Björn Corleis, Douglas S. Kwon

Scientific reports (Nature) USA, South Africa, UK, Germany, 16 February 2021

Virology

Key words: HIV infections, Monocytes and macrophages, Mucosal immunology, Retrovirus, Virology, Virus–host interactions

Organism: Human

Tissue: Lung

Pathological State: HIV infection

03
Imbalance of TGF-β1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness

J Ning, Y Ye, D Bu, G Zhao, T Song, P Liu, W Yu, H Wang, H Li, X Ren, G Ying, Y Zhao, J Yu

Molecular Therapy (Elsevier) China, 15 February 2021

Oncology

Organism: Human

Tissue: Liver

Pathological State: Cancer

04
Curcumin inhibits the growth of liver cancer by impairing myeloid‑derived suppressor cells in murine tumor tissues

S Tian, L Liao, Q Zhou, X Huang, P Zheng, Y Guo, T Deng, X Tian

Oncology Letters (Spandidos Publications) China, 12 February 2021

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

05
Global Analysis of Lysine Acetylome Reveals the potential role of CCL18 in non‐small cell lung cancer

S Kong, L Ding, C Fan, Y Li, C Wang, K Wang, W Xu, X Shi, Q Wu, F Wang

Proteomics (Wiley) China, 11 February 2021

Proteomics

Key words: acetylome, CCL18, non-small cell lung cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

06
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4

T Guo, YH Bai, XJ Cheng, HB Han, H Du, Y Hu, SQ Jia, XF Xing, JF Ji

Cancer Communications (Wiley) China, 11 February 2021

Oncology

Key words: gastric cancer, glucose transporter 4, glycolysis, insulin gene enhancer protein 1, tumorigenesis

Organism: Human

Tissue: Stomach

Pathological State: Cancer

07
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms

Wolf Eilenberg, Branislav Zagrapan, Sonja Bleichert, Nahla Ibrahim, Viktoria Knöbl, Annika Brandau, Luca Martelanz, Marie-Therese Grasl, Hubert Hayden, Paimann Nawrozi, Renata Rajic, Charlotte Häusler, Alexandros Potolidis, Nawa Schirwani, Andreas Scheuba, Johannes Klopf, Peter Teubenbacher, Markus P Weigl, Patrick Kirchweger, Dietrich Beitzke, Alexander Stiglbauer-Tscholakoff, Adelheid Panzenböck, Irene Lang, Lisa-Marie Mauracher, Lena Hell, Ingrid Pabinger, Marc A Bailey, D Julian A Scott, Lars Maegdefessel, Albert Busch, Ihor Huk, Christoph Neumayer, Christine Brostjan

Translational Research (Elsevier) Austria, UK, Sweden, 09 February 2021

Cardiology

Organism: Human

Tissue: Blood Vessels

Pathological State: Abdominal aortic aneurysms

08
IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer

G Jordakieva, R Bianchini, D Reichhold, J Piehslinger, A Groschopf, SA Jensen, E Mearini, G Nocentini, R Crevenna, GJ Zlabinger, SN Karagiannis, A Klaus, E Jensen-Jarolim

OncoImmunology (Taylor & Francis) Austria, Italy, UK, 08 February 2021

Oncology

Key words: IgG4, IgE, tumor-associated macrophages, M2b, allergooncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

09
Anti-inflammatory effects of Radix aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice

JH Liu, CH Hsieh, CY Liu, CW Chang, YJ Chen, TH Tsai

Journal of Ethnopharmacology (Elsevier) Taiwan, 07 February 2021

Pharmacology

Key words: 5-Fluorouracil (5-FU), Radix aucklandiae, Intestinal mucositis, Goblet cell, Anti-inflammatory

Organism: Mouse

Tissue: Small Intestine

Pathological State: Intestinal Mucositis

10
H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice.

L Ruilian, Q Honglin, X Jun, L Jianxin, B Qingyun, C Yilin, M Haifeng

Journal of Affective Disorders (Elsevier) China, 05 February 2021

Neuroscience

Key words: Chronic stress stimulated depression model, , Hippocampus, Hydrogen sulfide, Inflammatory, Aerobic exercise

Organism: Mouse

Tissue: Brain

11
Hiltonol Cocktail Kills Lung Cancer Cells by Activating Cancer-Suppressors, PKR/OAS, and Restraining the Tumor Microenvironment

SC Chang, BX Zhang, ECY Su, WC Wu, TH Hsieh, AM Salazar, YK Lin, JL Ding

International Journal of Molecular Sciences (MDPI) Taiwan, USA, Singapore, 05 February 2021

Oncology

Key words: NSCLC (non-small cell lung cancer), combinatorial treatment with Hiltonol+++ cocktail [Hiltonol+anti-IL6+stattic+AG490], tumorigenic microenvironment, anti- and pro-tumorigenic cytokine production, tumor-suppressors PKR (protein kinase R) and OAS (2′5′ oligoadenylate synthetase)

Organism: Human

Tissue: Lung

Pathological State: Cancer

12
Morphine acts on spinal dynorphin neurons to cause itch through disinhibition

E Nguyen, G Lim, H Ding, J Hachisuka, MC Ko, SE Ross

Science Translational Medicine (AAAS) USA, UK, 03 February 2021

Neuroscience

Organism: Mouse

Tissue: Skin

13
Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF

K Uranowska, T Kalic, V Valtsanidis, M Kitzwögerer, H Breiteneder, C Hafner

Oncology Reports (Spandidos Publications) Austria, 02 February 2021

Oncology

Organism: Human

Cell Line: Melanoma cells

14
Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer

J Yang, A Eresen, J Shangguan, Q Ma, V Yaghmai, Z Zhang

OncoImmunology (Taylor & Francis) USA, 02 February 2021

Oncology

Key words: Irreversible electroporation, dendritic cell vaccine, pancreatic ductal adenocarcinoma, magnetic resonance imaging

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

15
iTRAQ-based Quantitative Proteomic Analysis of Dural Tissues Reveals Upregulated Haptoglobin to be a Potential Biomarker of Moyamoya Disease

X Zhang, L Yin, X Jia, Y Zhang, T Liu, L Zhang

Current Proteomics (ingentaconnect) China, 01 February 2021

Proteomics

Key words: Moyamoya disease, dura mater, proteomics, iTRAQ, haptoglobin, strokes

16
Nerve Fibers in the Tumor Microenvironment Are Co-Localized with Lymphoid Aggregates in Pancreatic Cancer

LR Heij, X Tan, JN Kather, JM Niehues, S Sivakumar, N Heussen, G van der Kroft, SWM Olde Damink, S Lang, MR Aberle, T Luedde, NT Gaisa, J Bednarsch, DHW Liu, JPM Cleutjens, DP Modest, UP Neuman, GJ Wiltberger

Journal of Clinical Medicine (MDPI) Germany, The Netherlands, UK, Austria, 30 January 2021

Oncology

Key words: tumor microenvironment, machine learning, nerve fiber density, spatial arrangements, tertiary lymphoid structures, pancreatic cancer

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

17
Endothelial-Derived miR-17∼ 92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury

T Chiba, DM Cerqueira, Y Li, AJ Bodnar, E Mukherjee, K Pfister, YL Phua, K Shaikh, BT Sanders, SL Hemker, PJ Pagano, YL Wu, J Ho, S Sims-Lucas

Journal of the American Society of Nephrology (Am Soc Nephrol) USA, 29 January 2021

Nephrology

Key words: microRNA, acute kidney injury, renal microvasculature

18
Mer tyrosine kinase (MerTK) as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease

L Rovati, N Kaneko, F Pedica, A Monno, T Maehara, C Perugino, M Lanzillotta, S Pecetta, JH Stone, C Doglioni, AA Manfredi, S Pillai, E Della-Torre

Rheumatology (Oxford Academic) Italy, USA, Japan, 29 January 2021

Rheumatology

Key words: IgG4-related disease, macrophages, MerTK, Protein S, fibrosis

Organism: Human

Tissue: Submandibular Gland, Pancreas

Pathological State: Tissue Fibrosis

19
Effects of Nicorandil on Inflammation, Apoptosis and Atherosclerotic Plaque Progression

M Lenz, C Kaun, KA Krychtiuk, P Haider, M Brekalo, N Maier, L Goederle, CJ Binder, K Huber, C Hengstenberg, J Wojta, PJ Hohensinner, WS Speidl

Biomedicines (MDPI) Austria, 27 January 2021

Cardiology

Key words: nicorandil, inflammation, apoptosis, atherosclerosis, plaque, plaque stabilization

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerotic Plaque

20
Interleukin-24 protects against liver injury in mouse models

HH Wang, JH Huang, MH Sue, WC Ho, YH Hsu, KC Chang, MS Chang

EBioMedicine (THE LANCET) Taiwan, 25 January 2021

Hepathology

Key words: Interleukin-24, Liver fibrosis, Thioacetamide-induced liver injury, Hepatic stellate cells

Organism: Human

Tissue: Liver

Pathological State: Hepatitis

21
Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model

CY Yeung, JSC Chiau, ML Cheng, WT Chan, SW Chang, CB Jiang, HC Lee

Gastroenterology Research and Practice (Hindawi Publishing Corporation) Taiwan, 25 January 2021

Gastroenterology

Organism: Mouse

Tissue: Small Intestine

Pathological State: 5-FU-Induced Mucositis

22
A Hepatitis B Virus-Derived Peptide Exerts an Anticancer Effect via TNF/iNOS-producing Dendritic Cells in Tumor-Bearing Mouse Model

SB Yang, MH Lee, BR Kim, YM Choi, BJ Kim

Cancers (MDPI) South Korea, 22 January 2021

Oncology

Key words: HBV-derived poly6 peptide, TNF/iNOS-producing DCs (Tip-DCs), type 1 interferon (IFN-I), CD40, cancer immunotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

23
Androgen Plays a Carcinogenic Role in EOC via the PI3K/AKT Signaling Pathway in an AR-Dependent Manner

Y Li, S Li, Y Zhang, S Shi, S Qin, C Wang, J Du, J Ma, H Chen, H Cui

Journal of Cancer (Ivyspring International Publisher) China, 21 January 2021

Oncology

Key words: ovarian carcinoma, androgen receptor (AR), tissue microarray (TMA), proliferation promotion, PI3K/AKT signalling pathway

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

24
Performance and Meat Quality of Intrauterine Growth Restricted Pigs

P Matyba, T Florowski, K Dasiewicz, K Ferenc, J Olszewski, M Trela, G Galemba, M Słowiński, M Sady, D Domańska, Z Gajewski, R Zabielski

Animals (MDPI) Poland, 20 January 2021

Zoology

Key words: IUGR, pigs, growth performance, meat quality, sensory evaluation

Organism: Pig

Tissue: Muscle

25
Pathological Pulmonary Vascular Remodeling is Induced by Type V Collagen in a Model of Scleroderma

RG Marangoni, BD Korman, ER Parra, APP Velosa, HV Barbeiro, V Martins, ABG dos Santos, F Soriano, WR Teodoro, PL Silva, W Tourtellotte, VL Capelozzi, J Varga, NH Yoshinari

Pathology - Research and Practice (Elsevier) Brazil, USA, 19 January 2021

Cardiology

Key words: Animal model, scleroderma, Collagen V, Vascular disease, Endothelium

Organism: Rabbit

Tissue: Lung

Pathological State: Scleroderma

26
Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections

HY Park, SD Zoller, V Hegde, W Sheppard, Z Burke, G Blumstein, C Hamad, M Sprague, J Hoang, R Smith, FR Pastrana, J Czupryna, LS Miller, M López-Álvarez, M Bispo, M van Oosten, J Maarten van Dijl, KP Francis, NM Bernthal

Scientific reports (Nature) USA, The Netherlands, 15 January 2021

Medical Imaging

Key words: Biofilms, Infectious diseases

27
Macromolecular crowding as a tool to screen anti-fibrotic drugs: the Scar-in-a-Jar system revisited

NP Cavanzo, E Bigaeva, M Boersema, P Olinga, RA Bank

Frontiers in Medicine (Frontiers Media S.A.) The Netherlands, China, USA, Switzerland, 14 January 2021

Biological Methods

Key words: macromolecular crowding, drug testing, fibrosis, collagen, myofibroblast

Organism: Human

Cell Line: adult primary human dermal fibroblasts

28
PEG-GO@ XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to …

J Zhang, L Yan, P Wei, R Zhou, C Hua, M Xiao, Y Tu, Z Gu, T Wei

European Journal of Pharmacology (Elsevier) China, USA, 14 January 2021

Oncology, Nanomedicine

Key words: Graphene oxide, Xanthohumol, Breast cancer metastasis, Mitochondria, Epithelial-mesenchymal transition, Energy metabolism

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

29
Mesenchymal stem cell‐glioblastoma interactions mediated via kinin receptors unveiled by cytometry

MM Pillat, Á Oliveira‐Giacomelli, M das Neves Oliveira, R Andrejew, N Turrini, J Baranova, TL Turnšek, H Ulrich

Cytometry Part A (Wiley) Brazil, 13 January 2021

Medical Image Analysis

Key words: cytometry, glioblastoma, kinin receptors, kinin‐B1 receptor, kinin‐B2 receptor, mesenchymal stem cells

Organism: Human

Cell Line: Glioblastoma (U87) cells, Mesenchymal stem cell

30
Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition

YY Wang, B Zhao, MM Wu, XL Zheng, L Lin, DM Yin

Nature communications (Nature) China, 12 January 2021

Neuroscience

Key words: Molecular neuroscience, Schizophrenia

Organism: Mouse

Tissue: Brain

31
Stem Cell-Derived Respiratory Epithelial Cell Cultures as Human Disease Models

JC Orr, RE Hynds

American Journal of Respiratory Cell and Molecular Biology (Wiley) UK, 11 January 2021

Stem Cell Research

Key words: respiratory epithelium, epithelial cells, cell culture, cloning, stem cells

32
Overexpression of GLUT3 promotes metastasis of triple‐negative breast cancer by modulating the inflammatory tumor microenvironment

TH Tsai, CC Yang, TC Kou, CE Yang, JZ Dai, CL Chen, CW Lin

Journal of Cellular Physiology (Wiley) Taiwan, 09 January 2021

Oncology

Key words: glycolysis, inflammation, triple‐negative breast cancer, tumor microenvironment, tumor‐associated macrophage

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

33
Development and Validation of Sorafenib-eluting Microspheres to Enhance Therapeutic Efficacy of Transcatheter Arterial Chemoembolization in a Rat Model of of Hepatocellular Carcinoma

W Park, S Cho, J Ji, RJ Lewandowski, AC Larson, DH Kim

Radiology: Imaging Cancer (Royal Society of Chemistry) USA, 08 January 2021

Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

34
Differential expression of microRNA miR-150-5p in IgA nephropathy as a potential mediator and marker of disease progression.

IZA Pawluczyk, A Didangelos, SJ Barbour, L Er, JU Becker, R Martin, S Taylor, JS Bhachu, EG Lyons, R Jenkins, D Fraser, K Molyneux, J Perales-Paton, J Saez-Rodriguez, J Barratt

Kidney International (Elsevier) UK, Canada, Germany, Spain, 06 January 2021

Nephrology

Key words: IgA nephropathy, microRNA

Organism: Human

Tissue: Kidney

Pathological State: IgA nephropathy

35
Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1

Z Liu, L Sun, Y Cai, S Shen, T Zhang, N Wang, G Wu, W Ma, ST Li, C Suo, Y Hao, WD Jia, GL Semenza, P Gao, H Zhang

Cancer Research (AACR) China, USA, 05 January 2021

Oncology

36
IN VITRO CHARACTERIZATION OF HYDROXYAPATITE-BASED BIOMATERIALS, USING MESENCHYMAL STEM CELL CULTURES FROM HUMAN BONE …

LE Sima, RM Varut, O Gingu, G Sima, C Teisanu, J Neamtu

Journal of Science and Arts (Josa.ro) Romania, 30 December 2020

Biological Materials

Key words: hydroxyapatite, calcium fructoborate, mesenchymal stem cell, human bone marrow

Organism: Human

Cell Line: Mesenchymal stem cells

37
Persistent inhibition of Candida albicans biofilm and hyphae growth on titanium by graphene nanocoating

SV Agarwalla, K Ellepola, N Silikas, AHC Neto, C Jayampath, SV Rosa

Dental Materials (Elsevier) Singapore, USA, UK, 25 December 2020

Biological Materials

Key words: Implant, Surface free energy, Contact angle, Topography, Microbial attachment, Antiadhesive coating, Peri-Implantitis

Cell Line: C. albicans

38
Obesity is associated with shorter telomere length in prostate stromal cells in men with aggressive prostate cancer

CE Joshu, CM Heaphy, JR Barber, J Lu, R Zarinshenas, C Davis, M Han, TL Lotan, KS Sfanos, AM De Marzo, AK Meeker, EA Platz

Cancer Prevention Research (AACR) USA, 22 December 2020

Oncology

39
PD‐L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer

TJ Miller, CC Anyaegbu, TF Lee‐Pullen, LJ Spalding, CF Platell, MJ McCoy

Cancer Science (Wiley) Australia, 20 December 2020

Oncology

Key words: CD8, colon cancer, Dendritic cells, PD‐L1, T cells

40
Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma

T Tashiro, K Imamura, Y Tomita, D Tamanoi, A Takaki, K Sugahara, R Sato, K Saruwatari, S Sakata, M Inaba, S Ushijima, N Hirata, T Sakagami

International Journal of Molecular Sciences (MDPI) Japan, USA, 19 December 2020

Oncology

Key words: anaplastic lymphoma kinase (ALK), B cell, heterogeneity, immune checkpoint, large cell neuroendocrine carcinoma (LCNEC), neuroendocrine tumors (NET), regulatory T-cells (Tregs), programmed death-ligand 1 (PD-L1), tumor-infiltrating lymphocyte (TIL), tumor-immune microenvironments (TIME)

Organism: Human

Tissue: Lung

Pathological State: Cancer

41
Parp1-Dependent DNA Double-Strand Break Repair in Irradiated Late Pachytene Spermatocytes

E A. Ahmed, A M. Alzahrani, H Scherthan

DNA and Cell Biology (Mary Ann Liebert Inc.) Saudi Arabia, Egypt, Germany, 18 December 2020

Reproductive Medicine

Key words: alternative NHEJ, DNA repair, first meiotic prophase, γ-H2AX, homologous recombination, Parp1, spermatogenesis

Organism: Human

Cell Line: Spermatocytes

42
Differential mast cell phenotypes in benign versus cancer tissues and prostate cancer oncologic outcomes

H Hempel Sullivan, JP Maynard, CM Heaphy, J Lu, AM De Marzo, TL Lotan, CE Joshu, KS Sfanos

The Journal of Pathology (Wiley) USA, 18 December 2020

Oncology

Key words: Prostate cancer, mast cells, metastases, CXCR4, TFE3, KIT, microenvironment

Organism: Human

Tissue: Prostate

Pathological State: Cancer

43
ZFHX3 Knockdown Dysregulates Mitochondrial Adaptations to Tachypacing in Atrial Myocytes through Enhanced Oxidative Stress and Calcium Overload

B Lkhagva, YK Lin, YC Chen, WL Cheng, S Higa, YH

Acta Physiologica (Wiley) Taiwan, Japan, 17 December 2020

Physiology

Key words: atrial fibrillation, calcium, mitochondria, tachypacing, ZFHX3

Organism: Human

Cell Line: HL‐1 cells

44
CD4+ CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum

H Allard-Chamard, F Alsufyani, N Kaneko, K Xing, C Perugino, VS Mahajan, JL Wheat, GS Deepe Jr., J Loyd and S Pillai

The Journal of Immunology (American Association of Immunologists) Canada, Saudi Arabia, Japan, USA, 16 December 2020

Immunology

Organism: Human

Tissue: Mediastinum

Pathological State: Fibrosing Mediastinitis

45
Tribbles Pseudokinase 3 Contributes to Cancer Stemness of Endometrial Cancer Cells by Regulating β-Catenin Expression

WL Wang, GC Hong, PJ Chien, YH Huang, HT Lee, PH Wang, YC Lee, WW Chang

Cancers (MDPI) Taiwan, 15 December 2020

Oncology

Key words: tribbles pseudokinase 3, endometrial cancer, cancer stem cells, β-catenin, epithelial–mesenchymal transition

Organism: Human

Cell Line: Endometrial Cancer Cell Lines (AN3CA and HEC1A)

46
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

TJ Hark, NR Rao, C Castillon, T Basta, S Smukowski, H Bao, A Upadhyay, E Bomba-Warczak, T Nomura, ET O'Toole, GP Morgan, L Ali, T Saito, C Guillermier, TC Saido, ML Steinhauser, MHB Stowell, ER Chapman, A Contractor, JN Savas

Cell Systems (Cell Press) USA, Japan, 15 December 2020

Neuroscience

Key words: Alzheimer's diseasea, myloid beta, synaptic dysfunction, presynapse, synaptic vesicles, proteostasis, mass spectrometry, proteomics, APP knockin mice

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

47
Multi-Cohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors

K Ando, A Ozonoff, SY Lee, M Viosine, JT Parker, R Nakanishi, S Nishimura, J Yang, Z Grace, B Tran, TJ Diefenbach, Y Maehara, H Yasui, T Irino, R Salgia, M Terashima, P Gibbs, RK Ramanathan, E Oki, M Mori, M Kulke, K Hartshorn, A Bharti

Clinical Colorectal Cancer (Elsevier) USA, Japan, Australia, 10 December 2020

Oncology

Organism: Human

Tissue: Stomach

Pathological State: Cancer

48
Spatiotemporal Up-Regulation of Mu Opioid Receptor 1 in Striatum of Mouse Model of Huntington's Disease Differentially Affecting Caudal and Striosomal Regions

R Morigaki, JH Lee, T Yoshida, C Wüthrich, D Hu, JR Crittenden, A Friedman, Y Kubota, AM Graybiel

Frontiers in Neuroanatomy (Frontiers Media S.A.) USA, Japan, 10 December 2020

Neuroscience

Key words: mu opioid receptors, Huntington’s disease, neostriatum, movement disorders, mood disorders, animal models of human disorders, striosome

Organism: Mouse

Tissue: Brain

Pathological State: Huntington’s Disease

49
The effect of dietary supplementation with high-or low-dose omega-3 fatty acid on inflammatory pathology after traumatic brain injury in rats

EK Black, JK Phillips, J Seminetta, J Bailes, JM Lee, JD Finan

Translational Neuroscience (degruyter) USA, 09 December 2020

Neuroscience

Key words: dietary supplementation, docosahexanoic acid, eicosapentaenoic acid, neuroinflammation, neuroprotection, omega-3 fatty acid, traumatic brain injury

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

50
Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro

L Elena Sima, A Bonciu, M Baciu, I Anghel, LN Dumitrescu, L Rusen, V Dinca

Nanomaterials (MDPI) Romania, 09 December 2020

Nanomedicine

Key words: Zirconia, mesenchymal stem cells, micro-nano topography, osteogenic differentiation, bone-anchored hearing aid (BAHA)

Organism: Human

Cell Line: hMSCs

51
Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis

W Kang, Q Wang, Y Dai, H Wang, M Wang, J Wang, D Zhang, P Sun, T Qi, X Jin, Z Cui

Cell Death & Disease (Nature) China, 07 December 2020

Oncology

Key words: Bladder cancer, Long non-coding RNAs, Oncogenesis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

52
Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients

H Wang, C Feng, M Lu, B Zhang, Y Xu, Q Zeng, J Xi, J Zhou, X Ying, J Zhang, W Yue, X Pei

Translational Oncology (Elsevier) China, 06 December 2020

Oncology

Key words: Liver cancer, Single-cell transcriptome, Cancer-distinct fibroblast, SPARCL1

Organism: Human

Tissue: Liver

Pathological State: Cancer

53
Lactic acidosis interferes with toxicity of perifosine to colorectal cancer spheroids: multimodal imaging analysis

B Pavlatovská, M Machálková, P Brisudová, A Pruška, K Štěpka, J Michálek, T Nečasová, P Beneš, J Šmarda, J Preisler, M Kozubek, J Navrátilová

Frontiers in Oncology (Frontiers Media S.A.) Czech Republic, Switzerland, China, 04 December 2020

Oncology

Key words: perifosine, Akt kinase, tumor environment, lactic acidosis, alkalization, signal co-registration, mass spectrometry imaging, colorectal cancer

Organism: Human

Cell Line: HT-29 and HCT-116 cells

54
AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

G Caluori, E Odehnalova, T Jadczyk, M Pesl, I Pavlova, L Valikova, S Holzinger, V Novotna, V Rotrekl, A Hampl, M Crha, D Cervinka, Z Starek

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) Czech Republic, France, Poland, Germany, 03 December 2020

Cardiology

Key words: pulsed field ablation, irreversible electroporation (IRE), radiofrequency ablation, atrial fibrillation, ventricular arrhythmia (VA), preclinical cardiology

Organism: Pig

Tissue: Heart

55
Shear stress-exposed pulmonary artery endothelial cells fail to upregulate HSP70 in chronic thromboembolic pulmonary hypertension

W Salibe-Filho, TLS Araujo, EG Melo, LBCT Coimbra, MS Lapa, MMP Acencio, O Freitas-Filho, VL Capelozzi, LR Teixeira, CJCS Fernandes, F Biscegli Jatene, FRM Laurindo, M Terra-Filho

PloS one (PLOS) Brazil, 03 December 2020

Cardiology

Key words: Shear stresses, Endothelial cells, Heat shock response, Pulmonary arteries, Peas, Flow cytometry, Nitric oxide, Pulmonary hypertension

Organism: Human

Pathological State: Chronic thromboembolic pulmonary hypertension

Cell Line: HPAECs

56
Infiltration of metastatic lymph nodes with PD-1+ T cells is associated with improved disease-free and overall survival in resected N+ NSCLC

S Wang, Y Song, MA Morse, P Sun, G Qiao, X Wang, X Zhou, A Hobeika, J Ren, HK Lyerly

American Journal of Cancer Research (e-Century Publishing Corporation) China, USA, 01 December 2020

Oncology

Key words: NSCLC, metastatic lymph node, T cell subsets, PD-1, TIM-3

Organism: Human

Tissue: Lung

Pathological State: Cancer

57
The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients

G Spanier, I Ugele, F Nieberle, L Symeou, S Schmidhofer, A Brand, J Meier, S Spoerl, R Krupar, P Rümmele, P Siska, K Renner, K Peter, M Gerken, P Beckhove, TE Reichert, M Kreutz, K Singer

Cancer Letters (Elsevier) Germany, 01 December 2020

Oncology

Key words: OSCC, Diabetes mellitus, TIL, Metabolism, Prognosis

Organism: Human

Pathological State: Cancer

58
p21‐activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1

H Huang, Q Xue, X Du, J Cui, J Wang, D Cheng, J Li, Y Zheng, G Huang, K Zhang, K Liu, J Lu, J Zhao, X Chen, Z Dong, X Li

Molecular Carcinogenesis (Wiley) China, 01 December 2020

Oncology

Key words: cell proliferation, esophageal squamous cell carcinoma, LASP1, metastasis, PAK4

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

59
Cross-Reactive Effects of Vaccines: Heterologous Immunity between Tetanus and Chlamydia

M Stojanovic, I Lukic, E Marinkovic, A Kovacevic, R Miljkovic, J Tobias, I Schabussova, M Zlatovic, T Barisani-Asenbauer, U Wiedermann, A Inic-Kanada

Vaccines (MDPI) Serbia, Austria, 01 December 2020

Immunology

Key words: vaccination, heterologous immunity, antibodies, tetanus, Chlamydia, cross-reactivity

Organism: Human

Cell Line: Human conjunctival epithelial cell line

60
Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats

W Wang, X Liu, Z Yang, H Shen, L Liu, Y Yu, T Zhang

Frontiers in Neuroscience (Frontiers Media S.A.) China, 30 November 2020

Neuroscience

Key words: levodopa, hippocampus, global cerebral ischemia reperfusion injury, structural synaptic plasticity, cognitive function

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

61
Characterization of epithelial cells, connective tissue cells and immune cells in human upper airway mucosa by immunofluorescence multichannel image cytometry: a pilot study

AI Giotakis, J Dudas, R Glueckert, D Dejaco, J Ingruber, F Fleischer, V innerhofer, L Pinggera, L Bektic-Tadic, SAM Gabriel, H Riechelmann

Histochemistry and Cell Biology (Springer) Austria, 29 November 2020

Medical Image Analysis

Key words: Image cytometry, Fluorescent antibody technique, Immunohistochemistry, Nasal mucosa, Sinusitis

Organism: Human

Tissue: Mucosa

Pathological State: Chronic Rhinosinusitis

62
MicroRNA-146a suppresses tumor malignancy via targeting vimentin in esophageal squamous cell carcinoma cells with lower fibronectin membrane assembly

HY Chang, CH Lee, YS Li, JT Huang, SH Lan, YF Wang, WW Lai, YC Wang, YJ Lin, HS Liu, HC Cheng

Journal of Biomedical Science (BMC) Taiwan, 28 November 2020

Oncology

Key words: ESCC, miR-146a, Vimentin, Cell migration, Invasion

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

63
Lactobacillus Attenuate the Progression of Pancreatic Cancer Promoted by Porphyromonas Gingivalis in K-rasG12D Transgenic Mice

SM Chen, LJ Hsu, HL Lee, CP Lin, SW Huang, CJL Lai, CW Lin, WT Chen, YJ Chen, YC Lin, CC Yang, MS Jan

Cancers (MDPI) Taiwan, 26 November 2020

Oncology

Key words: caerulein, Lactobacillus, pancreatic ductal adenocarcinoma, Porphyromonas Gingivalis, transforming growth factor-β

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

64
Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages

YY Wang, HD Chen, S Lo, YK Chen, YC Huang, S CS Hu, YC Hsieh, AC Hung, MF Hou, SS F Yuan

Cancers (MDPI) Taiwan, UK, 26 November 2020

Oncology

Key words: visfatin, breast cancer, tumor-associated macrophages, CXCL1

Organism: Human

Tissue: Breast

Pathological State: Cancer

65
Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice

K Han, X Jin, X Guo, G Cao, S Tian, Y Song, Y Zuo, P Yu, G Gao, YZ Chang

Free Radical Biology and Medicine (Elsevier) China, 26 November 2020

Neuroscience

Key words: Nrf2, Motor dysfunction, Brain iron metabolism, Oxidative stress, FPN1

Organism: Mouse

Tissue: Brain

66
Neuropathology changed by 3-and 6-months low-level PM 2.5 inhalation exposure in spontaneously hypertensive rats

HC Chuang, HC Chen, PJ Chai, HT Liao, CF Wu, CL Chen, MK Jhan, HI Hsieh, KY Wu, TF Chen, TJ Cheng

Particle and Fibre Toxicology (Springer) Taiwan, 26 November 2020

Neuroscience

Key words: Air pollution, Autophagy, Central nervous system toxicity, Particulate matter, Tau

Organism: Rat

Tissue: Brain

67
Electric Pulse Responsive Magnetic Nanoclusters Loaded with Indoleamine 2, 3-Dioxygenase Inhibitor for Synergistic Immuno-Ablation Cancer Therapy

B Yu, W Zhang, K Kwak, H Choi, DH Kim

ACS Applied Materials & Interfaces (ACS Publications) USA, 25 November 2020

Oncology

Key words: local ablation, irreversible electroporation, indoleamine 2,3-dioxygenase inhibitor, magnetic nanoparticles, immunotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

68
Development of Rift valley fever encephalitis in rats is mediated by early infection of olfactory epithelium and neuroinvasion across the cribriform plate

DA Boyles, MM Schwarz, JR Albe, CM Mcmillen, KJ O'Malley, DS Reed, AL Hartman

Journal of General Virology (Microbiology Society) USA, 24 November 2020

Virology

Key words: aerosol, cribriform plate, encephalitis, olfactory bulb, pathogenesis, Rift Valley fever virus

Organism: Rat

Tissue: Mucosa

69
Time-resolved analysis of Staphylococcus aureus invading the endothelial barrier

EJM Raineri, H Yedavally, A Salvati, JM van Dijl

Virulence (Taylor & Francis) The Netherlands, 22 November 2020

Microbiology

Key words: Staphylococcus aureus, MRSA, endothelium, invasion, intracellular

Organism: Human

Cell Line: HUVECs

70
Type II natural killer T cells contribute to protection against systemic methicillin-resistant Staphylococcus aureus infection

S Genardi, L Visvabharathy, L Cao, E Morgun, Y Cui, C Qi, YH Chen, L Gapin, E Berdyshev, CR Wang

Frontiers in Immunology (Frontiers Media S.A.) USA, 18 November 2020

Immunology

Key words: Staphylococcus aureus, natural killer T cells, CD1, lipid antigens, cytokine, knockout mice

Organism: Mouse

Tissue: Kidney

Pathological State: Staphylococcus aureus Infection

71
Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease

J Strobl, RV Pandey, T Krausgruber, N Bayer, L Kleissl, B Reininger, P Vieyra-Garcia, P Wolf, MM Jentus, M Mitterbauer, W Rabitsch, G Stingl, C Bock, G Stray

Science Translational Medicine (AAAS) Austria, 18 November 2020

Dermatology

Organism: Human

Tissue: Skin

Pathological State: Graft-versus-host

72
Early plasma IL-37 responses accompanied with low inflammatory cytokines correlate with benign clinical outcomes during SARS-CoV-2 infection

Ang Li, Yun Ling, Zhigang Song, Xiaobo Cheng, Longfei Ding, Rendi Jiang, Weihui Fu, Yan Liu, Huiliang Hu, Songhua Yuan, Jian Chen, Cuisong Zhu, Jun Fan, Jing Wang, Yanling Jin, Miaomiao Zhang, Lingyan Zhu, Peng Sun, Linxia Zhang, Ran Qin, Wei Zhang, Chenli Qiu, Yinzhong Shen, Lin Zhang, Zhengli Shi, Chen Zhao, Tongyu Zhu, Hongzhou Lu, Xiaoyan Zhang, Jianqing Xu

The Journal of Infectious Diseases (Oxford Academic) China, 17 November 2020

Covid-19

Key words: IL-37, SARS-CoV-2, COVID-19, inflammation, clinical outcomes

Organism: Mouse

Tissue: Lung

Pathological State: SARS-CoV-2

73
Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model

A Ramírez-Fernández, L Urbina-Treviño, G Conte, M Alves, B Rissiek, A Durner, N Scalbert, J Zhang, T Magnus, F Koch-Nolte, N Plesnila, JM Deussing, T Engel, R Kopp, A Nicke

Scientific Reports (Nature) Germany, Ireland, 16 November 2020

Neuroscience

Key words: Biological techniques, Molecular biology, Neuroscience

Organism: Mouse

Tissue: Brain

74
HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age‐dependent changes

M Luque, A Schrott‐Fischer, J Dudas, E Pechriggl, E Brenner, H Rask-Andersen, W Liu, R Glueckert

Journal of Neuroscience Research (Wiley) Austria, 12 November 2020

Neuroscience

Key words: auditory development, auditory neuron diversity, axon initial segment, HCN channels, prestin, RRID:AB_90725, RRID:AB_2039906, RRID:AB_2302038, RRID:AB_2313584, RRID:AB_2313726, RRID:AB_2336419, RRID:AB_2336420, RRID:AB_2336790, RRID:AB_2340477, RRID:AB_2340452, RRID:AB_2340593, RRID:AB_2341028, RRID:AB_2617143, RRID:AB_2756625, RRID:AB_2756742, RRID:SCR_002865, RRID:SCR_013652, RRID:SCR_014823, sound coding, spiral ganglion neurons, voltage gated

Organism: Mouse, Human

75
Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

M Hara-Chikuma, M Tanaka, AS Verkman, M Yasui

Nature communications (Nature) Japan, USA, 09 November 2020

Hepathology

Key words: Molecular Drug discovery, Liver diseases, Molecular medicine

Organism: Mouse

Tissue: Bone Marrow

Pathological State: Liver Injury

76
CO2-Responsive Water-Soluble Conjugated Polymers for In Vitro and In Vivo Biological Imaging

CC Cheng, YC Lai, YT Shieh, YH Chang, AW Lee, JK Chen, DJ Lee, JY Lai

Biomacromolecules (ACS Publications) Taiwan, 06 November 2020

Medical Imaging

Organism: Zebrafish

Tissue: Whole Organism

77
Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19

Y Liu, J Lv, J Liu, M Li, J Xie, Q Lv, W Deng, N Zhou, Y Zhou, J Song, P Wang, C Qin, WM Tong, B Huang

Cell Research (Nature) China, 06 November 2020

Immunology, Covid-19

Key words: Immunology, Innate immunity

Organism: Mouse

Tissue: Lung

Pathological State: Covid-19

78
Evidence for a non-stochastic two-field hypothesis for persistent skin cancer risk

RL Konger, L Ren, RP Sahu, E Derr-Yellin, YL Kim

Scientific reports (Nature) USA, 05 November 2020

Oncology

Key words: Cancer microenvironment, Cancer models, Skin cancer, Squamous cell carcinoma

Organism: Mouse

Tissue: Skin

Pathological State: Cancer

79
Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14

R Widhalm, I Ellinger, S Granitzer, M Forsthuber, R Bajtela, K Gelles, PY Hartig, M Hengstschläger, H Zeisler, H Salzer, C Gundacker

Metallomics (Royal Society of Chemistry) Austria, 04 November 2020

Reproductive Medicine

Organism: Human

Tissue: Placenta

80
Metformin chlorination byproducts in drinking water exhibit marked toxicities of a potential health concern

R Zhang, Y He, L Yao, J Chen, S Zhu, X Rao, P Tang, J You, G Hua, L Zhang, F Ju, L Wu

Environment International (Elsevier) China, 03 November 2020

Toxicology

Key words: Metformin, Metformin chlorination byproduct, Drinking water, Toxicity, Public health

Organism: Mouse

Tissue: Small Intestine

81
Effect of route of administration on the efficacy of dendritic cell vaccine in PDAC mice

J Yang, A Eresen, J Shangguan, Q Ma, Z Zhang, V Yaghmai

American Journal of Cancer Research (e-Century Publishing Corporation) USA, 01 November 2020

Oncology

Key words: Pancreatic cancer, dendritic cell, route of administration

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

82
Therapeutic Efficacy of GC1118, a Novel Anti-EGFR Antibody, against Glioblastoma with High EGFR Amplification in Patient-Derived Xenografts

K Lee, H Koo, Y Kim, D Kim, E Son, H Yang, Y Lim, M Hur, H Won Lee, S Won Choi, DH Nam

Cancers (MDPI) South Korea, 31 October 2020

Oncology

Key words: glioblastoma, epidermal growth factor receptor, monoclonal, xenograft, amplification

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

83
P2Y2 receptor activation promotes esophageal cancer cells proliferation via ERK1/2 pathway

A Zaparte, AR Cappellari, CA Brandão, JB de Souza, TJ Borges, LW Kist, MR Bogo, LF Zerbini, LF Ribeiro Pinto, T Glaser, MCB Goncalves, Y Naaldijk, H Ulrich, FB Morrone

European Journal of Pharmacology (Elsevier) Brazil, USA, South Africa, 31 October 2020

Oncology

Key words: Esophageal cancer, Purinergic system, Nucleotide, P2Y2R, Proliferation, Signaling pathways

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

84
Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia–reperfusion injury

R Wang, M Wang, J Zhou, Z Dai, G Sun, X Sun

Journal of Advanced Research (Elsevier) China, 31 October 2020

Cardiology

Key words: Calenduloside E, myocardial ischemia-reperfusion injury, L-type calcium channelscalcium overload, Bcl2-associated athanogene 3

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

85
B Cell Activating Factor (BAFF) Is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats

L Steines, H Poth, M Herrmann, A Schuster, B Banas, T Bergler

International Journal of Molecular Sciences (MDPI) Germany, 28 October 2020

Nephrology

Key words: tertiary lymphoid organs, kidney transplantation, B cells, BAFF

Organism: Rat

Tissue: Kidney

86
Proteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model

RM Boteanu, VI Suica, L Ivan, F Safciuc, E Uyy, E Dragan, SM Croitoru, V Grumezescu, M Chiritoiu, LE Sima, C Vlagioiu, G Socol, F Antohe

Scientific reports (Nature) Romania, 28 October 2020

Osteology

Key words: Bioinformatics, Biological models, Fracture repair, Immunological techniques, Mass spectrometry, Microscopy, Proteomic analysis

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

87
Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma

Polina L. Yarova, Ping Huang, Martin W. Schepelmann, Richard Bruce, Rupert Ecker, Robert Nica, Vsevolod Telezhkin, Daniela Traini, Larissa Gomes dos Reis, Emma J. Kidd, William R. Ford, Kenneth J. Broadley, Benson M. Kariuki, Christopher J. Corrigan, Jeremy P.T. Ward, Paul J. Kemp and Daniela Riccardi

The Journal of Pharmacology and Experimental Therapeutics (ASPET) UK, Austria, Australia, 28 October 2020

Pharmacology

Organism: Mouse

Tissue: Lung

88
Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model

A Friedman, E Hueske, SM Drammis, SET Arana, ED Nelson, CW Carter, S Delcasso, RX Rodriguez, H Lutwak, KS DiMarco, Q Zhang, LI Rakocevic, D Hu, JK Xiong, J Zhao, LG Gibb, T Yoshida, CA Siciliano, TJ Diefenbach, C Ramakrishnan, K Deisseroth, AM Graybiel

Cell (Cell Press) USA, 27 October 2020

Neuroscience

Key words: corticostriatal, approach-avoidance, cost-benefit, decision-making, utility, subjective value, motivation, parvalbumin interneurons, VGluT1, excitation-inhibition balance

Organism: Mouse

Tissue: Brain

Pathological State: Huntington's Disease

89
The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer

F Mungenast, A Meshcheryakova, A Beer, M Salzmann, D Tamandl, T Gruenberger, P Pietschmann, O Koperek, P Birner, I Kirsch, H Robins, M Mittlboeck, M Jaritz, M Bergmann, P Zimmermann, D Mechtcheriakova

Cancers (MDPI) Austria, Switzerland, 25 October 2020

Oncology

Key words: lymphoid structures, colonic mucosa, metastatic colorectal cancer, immuno-oncology, B lymphocytes, germinal center, tissue image cytometry, B-cell clonality, compendium-wide analysis, patient stratification strategy

Organism: Human

Tissue: Colon

Pathological State: Cancer

90
Cross‐section modified and highly elastic sutures reduce tissue incision and show comparable biocompatibility: in‐vitro and in‐vivo evaluation of novel thermoplastic urethane surgical threads

M Helmedag, D Heise, R Eickhoff, KM Kossel, T Gries, S Jockenhoevel, UP Neumann, CD Klink, A Lambertz

Journal of Biomedical Materials Research Part B (Wiley) Germany, 24 October 2020

Tissue Engineering

Key words: animal trials, biocompatibility, elastic sutures, surface modified surgical threads, thermoplastic polyurethane, tissue incision

Organism: Rat

Tissue: Stomach

91
Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

Noam Jacob, Kotaro Kumagai, Jay P. Abraham, Yosuke Shimodaira, Yuefang Ye, Justin Luu, Anna Y. Blackwood, Sofi L. Castanon, Dalton T. Stamps, Lisa S. Thomas, Rivkah Gonsky, David Q. Shih, Kathrin S. Michelsen & Stephan R. Targan

Scientific reports (Nature) USA, 23 October 2020

Immunology, Gastroenterology

Key words: Cytokines, Gastroenterology, Immunology, Inflammation, Inflammatory bowel disease

Organism: Mouse

Cell Line: Mouse primary colonic fibroblasts

92
Impaired autophagy increases susceptibility to endotoxin-induced chronic pancreatitis

L Xia, Z Xu, X Zhou, F Bergmann, N Grabe, MW Büchler, JP Neoptolemos, T Hackert, G Kroemer, F Fortunato

Cell death & Disease (Nature) Germany, 21 October 2020

Gastroenterology

Key words: Acute pancreatitis, Chronic pancreatitis

Organism: Mouse

Tissue: Pancreas

Pathological State: Chronic Pancreatitis

93
Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma

A Makarevic, C Rapp, S Dettling, D Reuss, C Jungk, A Abdollahi, A van Deimling, A Unterberg, C Herold-Mende, R Warta

International Journal of Molecular Sciences (MDPI) Germany, 21 October 2020

Neuroscience

Key words: lower-grade glioma, T-cell infiltration, TissueFAXS, primary tumors, recurrent tumors, radiotherapy

Organism: Human

Tissue: Brain

Pathological State: Cancer

94
Tissue remodeling macrophages morphologically dominate at the interface of polypropylene surgical meshes in the human abdomen

A Dievernich, P Achenbach, L Davies, U Klinge

Hernia (Springer) Germany, UK, 18 October 2020

Tissue Engineering

Key words: Foreign body reaction, Macrophage, Collagen, Mesh, Fluorescence microscopy

Organism: Mouse

Tissue: Stomach

95
CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy

Yuncheng Bei, Nan Cheng, Ting Chen, Yuxin Shu, Ye Yang, Nanfei Yang, Xinyu Zhou, Baorui Liu, Jia Wie, Qin Liu, Wei Zheng, Wenlong Zhang, Huifang Su, Wei‐Guo Zhu, Jianguo Ji, Pingping Shen

Advanced Science (Wiley) China, 15 October 2020

Oncology

Key words: cancer stem cells, CD44 variants, CDK5, immune checkpoint blockade, PPARγ phosphorylation, triple‐negative breast cancer, tumor microenvironment

Organism: Human

Tissue: Breast

Pathological State: Cancer

96
Poly (ADP-ribose) polymerase inhibitor treatment as a novel therapy attenuating renal ischemia-reperfusion injury

HR Jang, K Lee, J Jeon, JR Kim, JE Lee, GY Kwon, YG Kim, DJ Kim, JW Ko, W Huh

Frontiers in Immunology (Frontiers Media S.A.) South Korea, Italy, France, 14 October 2020

Immunology

Key words: Acute kidney injury, Ischemia-reperfusion injury, poly(ADP-ribose) polymerase (PARP) inhibitor, parthanatos, inflammation, translational immunology

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

97
Two Polyurethane Adhesives for PVDF Fixation Show Superior Biocompatibility in a Rat Model

D Heise, Y Mirlas, M Helmedag, R Eickhoff, A Kroh, A Lambertz, CD Klink, UP Neumann, U Klinge, R Tolba

Journal of Investigative Surgery (Taylor & Francis) Germany, The Netherlands, 14 October 2020

Tissue Engineering

Key words: Mesh fixation, polyurethane adhesive, incisional hernia

Organism: Rat

Tissue: Stomach

98
FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

L Qiu, L Hu, H Wang, J Li, X Ruan, B Sun, J Zhi, X Zheng, L Gu, M Gao, P Kong, J Zhang

Cell death & Disease (Nature) China, 09 October 2020

Oncology

Key words: Apoptosis, Macroautophagy

Organism: Human

Cell Line: Human NSCLC cell lines (A549, H520, H358, H460, H1299 and U87)

99
Immune contexture analysis in immuno‐oncology: applications and challenges of multiplex fluorescent immunohistochemistry

R Shakya, TH Nguyen, N Waterhouse, R Khanna

Clinical & Translational Immunology (Wiley) Australia, 07 October 2020

Immunology

Key words: FCS express image cytometry, immune profiling, multiplexed fluorescent immunohistochemistry, quantitative digital pathology, tumor microenvironment, vectra

100
Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring: role for AREG-induced EGFR signaling

K Lkhagvadorj, Z Zeng, J Song, M Reinders-Luinge, W Kooistra, S Song, S Krauss-Etschmann, BN Melgert, J Cao, MN Hylkema

Journal of Physiology-Lung … (American Physiological Society) The Netherlands, Mongolia, Germany, China, 06 October 2020

Pulmonology

Key words: amphiregulin, epithelial cell differentiation, lung organoids, prenatal smoke exposure

Organism: Mouse

Tissue: Lung

101
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency

Melanie Werner-Klein, Ana Grujovic, Christoph Irlbeck, Milan Obradović, Martin Hoffmann, Huiqin Koerkel-Qu, Xin Lu, Steffi Treitschke, Cäcilia Köstler, Catherine Botteron, Kathrin Weidele, Christian Werno, Bernhard Polzer, Stefan Kirsch, Miodrag Gužvić, Jens Warfsmann, Kamran Honarnejad, Zbigniew Czyz, Giancarlo Feliciello, Isabell Blochberger, Sandra Grunewald, Elisabeth Schneider, Gundula Haunschild, Nina Patwary, Severin Guetter, Sandra Huber, Brigitte Rack, Nadia Harbeck, Stefan Buchholz, Petra Rümmele, Norbert Heine, Stefan Rose-John & Christoph A. Klein

Nature Communications (Nature) Germany, Switzerland, 05 October 2020

Oncology

Key words: Breast cancer, Cancer

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

102
Innovations present in the primate interneuron repertoire

Fenna M. Krienen, Melissa Goldman, Qiangge Zhang, Ricardo C. H. del Rosario, Marta Florio, Robert Machold, Arpiar Saunders, Kirsten Levandowski, Heather Zaniewski, Benjamin Schuman, Carolyn Wu, Alyssa Lutservitz, Christopher D. Mullally, Nora Reed, Elizabeth Bien, Laura Bortolin, Marian Fernandez-Otero, Jessica D. Lin, Alec Wysoker, James Nemesh, David Kulp, Monika Burns, Victor Tkachev, Richard Smith, Christopher A. Walsh, Jordane Dimidschstein, Bernardo Rudy, Leslie S. Kean, Sabina Berretta, Gord Fishell, Guoping Feng & Steven A. McCarroll

Nature (Nature) USA, 30 September 2020

Neuroscience

Key words: Evolutionary biology, Genetics of the nervous system, Transcriptomics

Organism: Mouse

Tissue: Brain

103
Peptide-Based TNF-α-Binding Decoy Therapy Mitigates Lipopolysaccharide-Induced Liver Injury in Mice

CY Chang, HJ Hsu, J Foo, HJ Shih, CJ Huang

Pharmaceuticals (MDPI) Taiwan, 29 September 2020

Hepathology

Key words: TNF-α, necroptosis, pyroptosis, apoptosis, autophagy, mitochondrial injury

Organism: Mouse

Tissue: Liver

104
Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes

HT Wu, L Kang, YC Su, HY Ou, FY Chan, BH Su, YS Wang, CL Wu, AL Shiau, P Wu

Clinical Science (Portland Press) Taiwan, UK, 25 September 2020

Endocrinology

Key words: fibrosis, gestational diabetes, placenta, prothymosin α, trophoblast

105
A Systemic Prime–Intrarectal Pull Strategy Raises Rectum-Resident CD8+ T Cells for Effective Protection in a Murine Model of LM-OVA Infection

Q He, L Jiang, K Cao, L Zhang, X Xie, S Zhang, X Ding, Y He, M Zhang, C Zhao, X Zhang, J Xu

Frontiers in Immunology (Frontiers Media S.A.) China, 24 September 2020

Immunology

Key words: mucosal immune response, rectum TRM, prime–pull vaccination strategy, HIV, Listeria monocytogenes

Organism: Mouse

Tissue: Lung

106
Discoidin Domain Receptors 1 Inhibition Alleviates Osteoarthritis via Enhancing Autophagy

HC Chou, CH Chen, LY Chou, TL Cheng, L Kang, SC Chuang, YS Lin, ML Ho, YH Wang, SY Lin, CZ Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 23 September 2020

Rheumatology

Key words: discoidin domain receptors 1 (Ddr1), osteoarthritis (OA), autophagy, apoptosis, terminal differentiation

Organism: Mouse

Tissue: Bone

Pathological State: Osteoarthritis

107
Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury

X Zhang, Y Jing, C Qin, C Liu, D Yang, F Gao, M Yang, L Du, J Li

Journal of Cellular and Molecular Medicine (Wiley) China, 17 September 2020

Neuroscience

Key words: apoptosis, autophagic flux, decompression, mechanical stress, mTOR, spinal cord injury

Organism: Rabbit

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

108
Two common polymorphic variants of OATP4A1 as potential risk factors for colorectal cancer

Veronika Buxhofer‑Ausch, Orsolya Német, Majdah Sheikh, Hajnalka Andrikovics, Angelika Reiner, Christoph Ausch, Diana Mechtcheriakova, Attila Tordai, Andreas Gleiss, Csilla Özvegy‑laczka, Walter Jäger, Theresia Thalhammer

Oncology Letters (Spandidos Publications) Austria, Hungary, 17 September 2020

Oncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

109
Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins through BIP

J Chen, Z Chen, M Liu, T Qiu, D Feng, C Zhao, S Zhang, X Zhang, J Xu

mBio (American Society for Microbiolgy) China, 15 September 2020

Virology

Key words: BIP, placental alkaline phosphatase, Zika virus, placental trophoblast cells

Organism: Human

Cell Line: U-251 MG, JEG-3, and HK2 cells

110
IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models

SW Lu, HC Pan, YH Hsu, KC Chang, LW Wu, WY Chen, MS Chang

Nature Communications (Nature) Taiwan, 14 September 2020

Oncology

Key words: Interleukins, Pancreatic cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

111
In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP) 1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta

Sebastian Granitzer, Isabella Ellinger, Rumsha Khan, Katharina Gelles, Raimund Widhalm, Markus Hengstschläger, Harald Zeisler, Gernot Desoye, Lenka Tupova, Martina Ceckova, Hans Salzer, Claudia Gundacker

Archives of Toxicology (Springer) Austria, Czech Republic, 11 September 2020

Toxicology

Key words: Multidrug resistance-associated protein 1, Methyl mercury, HTR-8/Svneo, MDCKII, Oxidative stress, Human placenta

Organism: Human

Tissue: Placenta

112
The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix

S Taylor, M Whitfield, J Barratt, A Didangelos

The Journal of Immunology (American Association of Immnologists) UK, 11 September 2020

Immunology

Organism: Human

Tissue: Kidney

113
Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury

S Lu, Y Tian, Y Luo, X Xu, W Ge, G Sun, X Sun

Journal of Advanced Research (Elsevier) China, 09 September 2020

Cardiology

Key words: Myocardial ischemia-reperfusion, Macrophage, Iminostilbene, Pyruvate kinase M2

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

114
Integrin VLA-4 as a PET imaging biomarker of hyper-adhesion in transgenic sickle mice

Lydia A. Perkins, Lea Nyiranshuti, Lynda Little-Ihrig, Joseph D. Latoche, Kathryn E. Day, Qin Zhu, Sina Tavakoli, Prithu Sundd, Enrico M. Novelli, Carolyn J. Anderson

Blood Advances (ASH Publications) USA, 03 September 2020

Cardiology

Key words: adhesions, biological markers, diagnostic imaging, integrins, mice, monoclonal antibodies, positron-emission tomography, selectins, flow cytometry, femur

Organism: Mouse

Tissue: Bone, Spleen

115
Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis

Z Guan, Z Chen, S Fu, L Dai, Y Shen

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China, 03 September 2020

Neuroscience

Key words: Alzheimer’s disease, progranulin, Aβ, BACE1, microglia

Organism: Mouse

Tissue: Brain

116
Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft

M Enayati, S Puchhammer, J Iturri, C Grasl, C Kaun, S Baudis, I Walter, H Schima, R Liska, J Wojta, JL Toca-Herrera, BK Podesser, H Bergmeister

Journal of the Mechanical Behavior of Biomedical Materials (Elsevier) Austria, 03 September 2020

Tissue Engineering

Key words: Biodegradation, Mechanical stability, Macrophages, Thermoplastic polyurethane, Cell culture, Rat model

Organism: Rat

117
Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft

M Enayati, S Puchhammer, J Iturri, C Grasl, C Kaun, S Baudis, I Walter, H Schima, R Liska, J Wojta, JL Toca-Herrera, BK Podesser, H Bergmeister

Journal of the Mechanical Behavior of Biomedical Materials (Elsevier) Austria, 03 September 2020

Biological Materials

Key words: Biodegradation, Mechanical stability, Macrophages, Thermoplastic polyurethane, Cell culture, Rat model

118
Murine induced pluripotent stem cell‐derived neuroimmune cell culture models emphasize opposite immune‐effector functions of interleukin 13‐primed microglia and macrophages in terms of neuroimmune toxicity

A Quarta, T Meese, Z Pieters, E Van Breedam, D Le Blon, J Van Broeckhoven, S Hendrix, H Goossens, N Hens, Z Berneman, F Van Nieuwerburgh, P Ponsaerts

Glia (Wiley) Belgium, Germany, Spain, The Netherlands, 31 August 2020

Neuroscience

Key words: bioluminescence imaging, interleukin 13, iPSC, macrophages, microglia, neurotoxicity, transcriptome

Organism: Human

Cell Line: iPSC‐macrophages

119
The Secretome of Stressed Peripheral Blood Mononuclear Cells Increases Tissue Survival in a Rodent Epigastric Flap Model

Stefan Hacker, Rainer Mittermayr, Denise Traxler, Claudia Keibl, Annika Resch, Stefan Salminger, Harald Leiss, Philipp Hacker, Christian Gabriel, Bahar Golabi, Reinhard Pauzenberger, Paul Slezak, Maria Laggner, Michael Mildner, Wolfgang Michlits, Hendrik J. Ankersmit

Bioengineering & Translational Medicine (Wiley) Austria, 30 August 2020

Tissue Engineering

Key words: secretome, angiogenesis, flap surgery, necrosis reconstructive surgery, tissue regeneration

Organism: Rat

Tissue: Skin

120
Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential‐dependent NET‐formation

M Reithofer, J Karacs, J Strobl, C Kitzmüller, D Polak, K Seif, M Kamalov, CFW Becker, G Greiner, K Schmetterer

The FASEB Journal (Wiley) Austria, 29 August 2020

Cardiology

Key words: aluminium hydroxide, vaccine, adjuvant, innate response, neutrophils, NET

Organism: Human

Tissue: Skin

121
Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation

Y Zhou, M Yan, R Pan, Z Wang, X Tao, C Li, T Xia, X Liu, Q Chang

Journal of Ethnopharmacology (Elsevier) China, 28 August 2020

Neuroscience

Key words: Depression, Radix polygalae, Chronic restraint stress, Autophagy, Neuroinflammation

Organism: Mouse

Tissue: Brain

122
Topography-Mediated Myotube and Endothelial Alignment, Differentiation, and Extracellular Matrix Organization for Skeletal Muscle Engineering

AM Almonacid Suarez, MGL Brinker, LA Brouwer, I van der Ham, MC Harmsen, P van Rijn

Polymers (MDPI) The Netherlands, 28 August 2020

Tissue Engineering

Key words: myoblasts, topography, vascularization, endothelial cells, skeletal muscle, extracellular matrix

Organism: Human

Tissue: Muscle

123
Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor

L Iamartino, T Elajnaf, K Gall, J David, T Manhardt, P Heffeter, M Grusch, S Derdak, S Baumgartner-Parzer, M Schepelmann, E Kallay

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (Elsevier) Austria, 27 August 2020

Oncology

Key words: Calcium-sensing receptor, Calcimimetic, Colorectal cancer, Inflammation, Intestine

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

124
The Effects of Skin Lesion Segmentation on the Performance of Dermatoscopic Image Classification

A Mahbod, P Tschandl, G Langs, R Ecker, I Ellinger

Computer Methods and Programs in Biomedicine (Elsevier) Austria, 26 August 2020

Medical Image Analysis

Key words: Skin cancer, dermatoscopy, medical image analysis, deep learning, effect of segmentation on classification

125
Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

Jason K. Sa, Nakho Chang, Hye Won Lee, Hee Jin Cho, Michele Ceccarelli, Luigi Cerulo, Jinlong Yin, Sung Soo Kim, Francesca P. Caruso, Mijeong Lee, Donggeon Kim, Young Taek Oh, Yeri Lee, Nam-Gu Her, Byeongkwi Min, Hye-Jin Kim, Da Eun Jeong, Hye-Mi Kim, Hyunho Kim, Seok Chung, Hyun Goo Woo, Jeongwu Lee, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Jinho Kim, Woong-Yang Park, Qianghu Wang, Erik P. Sulman, Amy B. Heimberger, Michael Lim, Jong Bae Park, Antonio Iavarone, Roel G. W. Verhaak & Do-Hyun Nam

Genome Biology (BMC) South Korea, Italy, China, USA, 26 August 2020

Oncology

Organism: Human

Tissue: Brain

Pathological State: Cancer

126
Hindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption

R Gong, S Xu, A Hermundstad, Y Yu, SM Sternson

CELL (Cell Press) USA, 24 August 2020

Neuroscience

Key words: hunger, thirst, palatability, locus coeruleus, locus ceruleus, periLC, ingestive behavior, appetite, in vivo calcium imaging, GRIN lens

Organism: Mouse

127
Interruption of vascular endothelial growth factor receptor 2 signaling induces a proliferative pulmonary vasculopathy and pulmonary hypertension

Max-Paul Winter, Smriti Sharma, Johanna Altmann, Veronika Seidl, Adelheid Panzenböck, Arman Alimohammadi, Thomas Zelniker, Bassam Redwan, Felix Nagel, David Santer, Alexander Stieglbauer, Bruno Podesser, Maria Sibilia, Thomas Helbich, Gerald Prager, Aysegül Ilhan-Mutlu, Matthias Preusser, Irene M. Lang

Basic Research in Cardiology (Springer) Austria, Germany, 23 August 2020

Pulmonology

Key words: Pulmonary hypertension, VEGFR-2, FLK, Kdr, Murine model

Organism: Mouse

Tissue: Lung

128
Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19

Naoki Kaneko, Hsiao-Hsuan Kuo, Julie Boucau, Jocelyn R. Farmer, Hugues Allard-Chamard, Vinay S. Mahajan, Alicja Piechocka-Trocha, Kristina Lefteri, Matthew Osborn, Julia Bals, Yannic C. Bartsch, Nathalie Bonheur, Timothy M. Caradonna, Josh Chevalier, Fatema Chowdhury, Thomas J. Diefenbach, Kevin Einkauf, Jon Fallon, Jared Feldman, Kelsey K. Finn, Pilar Garcia-Broncano, Ciputra Adijaya Hartana, Blake M. Hauser, Chenyang Jiang, Paulina Kaplonek, Marshall Karpell, Eric C. Koscher, Xiaodong Lian, Hang Liu, Jinqing Liu, Ngoc L. Ly, Ashlin R. Michell, Yelizaveta Rassadkina, Kyra Seiger, Libera Sessa, Sally Shin, Nishant Singh, Weiwei Sun, Xiaoming Sun, Hannah J. Ticheli, Michael T. Waring, Alex L.

CELL (Cell Press) USA, Canada, 19 August 2020

Covid-19

Key words: SARS-CoV-2, COVID-19, T follicular helper cells, germinal centers, double-negative B cells, extra-follicular B cells, plasmablasts, humoral immunity, TNF-α, cytokine dysregulation

Organism: Human

Tissue: Lymphoid Tissue, Spleen

Pathological State: Covid-19

129
Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

R Vatapalli, V Sagar, Y Rodriguez, JC Zhao, K Unno, S Pamarthy, B Lysy, J Anker, H Han, YA Yoo, M Truica, ZR Chalmers, F Giles, J Yu, D Chakravarti, B Carneiro, SA Abdulkadir

Nature Communications (Nature) USA, 19 August 2020

Oncology

Key words: Epigenomics, Prostate cancer, Targeted therapies

Organism: Human

Tissue: Prostate

Pathological State: Cancer

130
Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer

V Stary, B Wolf, D Unterleuthner, J List, M Talic, J Längle, A Beer, J Strobl, G Stary, H Dolznig, M Bergman

Journal for ImmunoTherapy of Cancer (BMJ Journals) Austria, 18 August 2020

Oncology

Key words: macrophages, radiotherapy, tumor microenvironment

Organism: Human

Tissue: Colon

Pathological State: Cancer

131
Epithelial cell–specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice

HC Do-Umehara, C Chen, Q Zhang, AV Misharin, H Abdala-Valencia, SM Casalino-Matsuda, PA Reyfman, KR Anekalla, FJ Gonzalez-Gonzalez, MA Sala, C Peng, P Wu, CCL Wong, R Kalhan, A Bharat, H Perlman, KM Ridge, JI Sznajder, PHS Sporn, NS Chandel, J Yu, X Fu, I Petrache, R Tuder, GRS Budinger, J Liu

Science Advances (AAAS) USA, China, 14 August 2020

Immunology

Organism: Human

Tissue: Lung

Pathological State: Chronic obstructive pulmonary disease

132
Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring-Role for AREG-induced EGFR signaling.

K Lkhagvadorj, Z Zeng, J Song, M Reinders-Luinge, W Kooistra, S Song

American Journal of Physiology (American Physiological Society) The Netherlands, China, 12 August 2020

Pulmonology

Key words: Prenatal smoke exposure, Epithelial cell differentiation, Amphiregulin, Lung organoids

Organism: Mouse

Tissue: Lung

133
Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression

CC Lin, IY Kuo, LT Wu, WH Kuan, SY Liao, J Jen, YE Yang, CW Tang, YR Chen, YC Wang

Theranostics (Ivyspring International Publisher) Taiwan, 08 August 2020

Oncology

Key words: Lung cancer, Kras, Shh, transcription, angiogenesis

Organism: Human

Tissue: Lung

Pathological State: Cancer

134
The effects of CYP24A1 on clinicopathological features and the prognosis of pancreatic ductal adenocarcinoma

W Gao, TF Wang, W Yi, WM Tong

Translational Cancer Research (AME Publishing Company) China, 08 August 2020

Oncology

Key words: CYP24A1, pancreatic cancer, prognosis

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

135
Human FBXL8 Is a Novel E3 Ligase Which Promotes BRCA Metastasis by Stimulating Pro-Tumorigenic Cytokines and Inhibiting Tumor Suppressors

SC Chang, W Hsu, ECY Su, CS Hung, JL Ding

Cancers (MDPI) Taiwan, Singapore, 07 August 2020

Oncology

Key words: FBXL8 SCF E3 ubiquitin ligase, CCND2, IRF5, breast cancer (BRCA) and metastasis, pro-tumorigenic microenvironment

Organism: Human

Cell Line: MCF7 and MDA-MB231 cells

136
Pyramidal shaped ceria nano-biointerfaces for studying the early bone cell response

AF Bonciu, S Orobeti, LE Sima, M Icriverzi, M Filipescu, A Moldovan, A Popescu, V Dinca, M Dinescu

Applied Surface Science (Elsevier) Romania, 06 August 2020

Biological Materials

Key words: Pyramidal shaped ceria nano-biointerfaces, PLD, cells response

Organism: Human

Cell Line: Human osteosarcoma cells (SaOs-2)

137
Sodium Cholate Bile Acid-Stabilized Ferumoxytol-Doxorubicin-Lipiodol Emulsion for Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

K Kwak, B Yu, SK Mouli, AC Larson, DH Kim

Journal of Vascular and Interventional Radiology (Elsevier) USA, 06 August 2020

Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

138
Light‐emitting diode irradiation induces AKT/mTOR‐mediated apoptosis in human pancreatic cancer cells and xenograft mouse model

YM Kim, SH Ko, YI Shin, Y Kim, T Kim, J Jung, SY Lee, NG Kim, KJ Park, JH Ryu

Journal of Cellular Physiology (Wiley Online Library) South Korea, 04 August 2020

Oncology

Key words: AKT/mTOR pathway, apoptosis, LED irradiation, pancreatic cancer, tumor growth

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

139
Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

Mayank Srivastava, Ying Zhang, Jian Chen, Devika Sirohi, Andrew Miller, Yang Zhang, Zhilu Chen, Haojie Lu, Jianqing Xu, Richard J. Kuhn & W. Andy Tao

Nature communications (Nature) USA, China, 04 August 2020

Virology

Key words: Chemical tools, Proteomics, Virus–host interactions

Organism: Human

Cell Line: HEK293T cells

140
Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes

YJ Huang, TH Huang, VK Yadav, M Rachmawati Sumitra, DTW Tzeng, PL Wie, JW Shih, ATH Wu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, China, 01 August 2020

Oncology

Key words: Colon cancer stem cells, tumor microenvironment, 5-FU resistance, tumorsphere derived exosomes, β-catenin/STAT3/miR-1246 signaling, and ovatodiolide

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

141
Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells

A Yawer, E Sychrová, P Labohá, J Raška, T Jambor, P Babica, I Sovadinová

Toxicology and Applied Pharmacology (Elsevier) Czech Republic, Slovakia, 31 July 2020

Endocrinology

Key words: Connexins, Endocrine-disrupting chemicals, Gap junctional intercellular communication, Leydig cells, Reproductive toxicants, Steroidogenesis

Organism: Mouse

Cell Line: Leydig TM3 cells

142
Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin

L Molcan, A Maier, A Zemančíková, K Gelles, J Török, M Zeman, I Ellinger

Cellular and Molecular Neurobiology (Springer) Slovakia, Austria, 30 July 2020

Cardiology

Key words: Rat melatonin receptor MT1, Melatonin, Mesenteric artery (MA), Perivascular fat tissue (PVAT), Neurogenic contraction

Organism: Rat

Tissue: Eye, Brain

143
Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy

J Ye, S Lu, M Wang, W Ge, H Liu, Y Qi, J Fu, Q Zhang, B Zhang, G Sun, X Sun

Frontiers in Pharmacology (Frontiers Media S.A.) China, 30 July 2020

Cardiology

Key words: myocardial ischemia reperfusion injury, hydroxysafflor yellow A, NLRP3, autophagy, AMPK

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

144
A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model

IJ Su, HY Chang, HC Wang, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan, 30 July 2020

Neuroscience

Key words: Alzheimer’s disease therapy, curcumin analog, TML-6, aging, bioavailability

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

145
NHF-derived carbon dots: prevalidation approach in breast cancer treatment

Crina Elena Tiron, Gabriel Luta, Mihail Butura, Florin Zugun-Eloae, Corneliu S. Stan, Adina Coroaba, Elena-Laura Ursu, Gabriela Dumitrita Stanciu & Adrian Tiron

Scientific Reports (Nature) Romania, 29 July 2020

Oncology

Key words: Cancer, Drug development, Medical research, Oncology, Preclinical research, Translational research

Organism: Human

Cell Line: HUVECs and PASMCs

146
BMI1-Mediated Pemetrexed Resistance in Non-Small Cell Lung Cancer Cells Is Associated with Increased SP1 Activation and Cancer Stemness

HT Shen, PJ Chien, SH Chen, GT Sheu, MS Jan, BY Wang, WW Chang

Cancers (MDPI) Taiwan, 27 July 2020

Oncology

Key words: BMI1, SP1, pemetrexed resistance, non small cell lung cancer, cancer stem cells, epithelial–mesenchymal transition

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

147
A general method to optimize and functionalize red-shifted rhodamine dyes

JB Grimm, AN Tkachuk, L Xie, H Choi, B Mohar, N Falco, K Schaefer, R Patel, Q Zheng, Z Liu, J Lippincott-Schwartz, TA Brown, LD Lavis

Nature methods (Nature) USA, 27 July 2020

Biological Methods

Key words: Chemical biology, Chemical tools, Fluorescence imaging, Imaging

Organism: Mouse

Tissue: Brain

148
Ready to go 3D? A semi-automated protocol for microwell spheroid arrays to increase scalability and throughput of 3D cell culture testing

A Basu, A Dydowiczová, JE Trosko, L Bláha, P Babica

Toxicology Mechanisms and Methods (Taylor & Francis) Czech Republic, USA, 26 July 2020

Biological Methods

Organism: Human

Cell Line: HL1-hT1 cells and HepG2 cells

149
Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents–Implications for oxidative UV damage

C Kremslehner, A Miller, R Nica, IM Nagelreiter, MS Narzt, B Golabi, V Vorstandlechner, M Mildner, J Lachner, E Tschachler, F Ferrara, K Klavins, M Schlosserer, J Grillari, A Haschemi, F Gruber

Redox Biology (Elsevier) Austria, Italy, USA, 19 July 2020

Dermatology

Organism: Human

Tissue: Skin

150
Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets

P Haider, JB Kral-Pointner, J Mayer, M Richter, C Kaun, C Brostjan, W Ellenberg, MB Fischer, WS Spledl, C Hengstenberg, K Huber, J Wojta, P Hohensinner

Arteriosclerosis,Thrombosis, and Vascular Biology (American Heart Association) Austria, 16 July 2020

Cardiology

Key words: aortic aneurysm, extracellular traps, humans, macrophages, thrombosis

Organism: Mouse

Cell Line: Blood

151
Enterocyte-Based Bioassay via Quantitative Combination of Proinflammatory Sentinels Specific to 8-keto-trichothecenes

SH Park, Y Moon

Frontiers in Immunology (Frontiers Media S.A.) South Korea, 16 July 2020

Immunology

Key words: 8-keto-trichothecene, ribotoxic stress, inflammation, epithelium, reporter biomonitoring

Organism: Mouse

Tissue: Small Intestine

152
Pre-and post-irradiation mild hyperthermia enabled by NIR-II for sensitizing radiotherapy

Q Li, L Hang, W Jiang, J Dou, L Xiao, X Tang, Y Yao, Y Wang

Biomaterials (Elsevier) China, 14 July 2020

Biological Materials

Key words: Au nanobipyramids, Second near-infrared window, Mild hyperthermia, Radiotherapy

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

153
Antidiabetic activity in vitro and in vivo of BDB, protein tyrosine phosphatase 1B selective inhibitor from Rhodonela conferviodes

J Luo, M Zheng, B Jiang, C Li, S Guo, L Wang, X Li, R Yu, D Shi

British Journal of Pharmacology (Wiley) China, 14 July 2020

Pharmacology

Key words: Bromophenol, PTP1B inhibitor, Selectivity, Cell permeability, oral bioavailability

Organism: Mouse

Tissue: Pancreas

Pathological State: Diabetes

154
Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

D Dems, R Freeman, T Coradin, SI Stupp, C Aime

Acta Biomaterialia (SSRN) France, USA, 13 July 2020

Biological Materials

Key words: Peptide amphiphile, silica particles, nanobiocomposites, hybrid biomaterials, clustering

Organism: Mouse

Cell Line: NIH 3T3 fibroblasts

155
Lycopene Inhibit IMQ-Induced Psoriasis-Like Inflammation by Inhibiting ICAM-1 Production in Mice

CM Shih, CK Hsieh, CY Huang, CY Huang, KH Wang, TH Fong, NTT Trang, KT Liu, AW Lee

Polymers (MDPI) Taiwan, 09 July 2020

Dermatology

Key words: lycopene, psoriasis

Organism: Mouse

Tissue: Skin

Pathological State: Psoriasis

156
Using Cytometry for Investigation of Purinergic Signaling in Tumor‐Associated Macrophages

VF Arnaud‐Sampaio, ILA Rabelo, CA Bento, T Glaser, J Bezerra, R Coutinho-Silva, H Ulrich, C Lameu

Cytometry Part A (Wiley) Brazil, 07 July 2020

Oncology

Key words: macrophage, TAM, cancer stem cells, purines, ATP, purinergic system, EMT, image cytometry

Organism: Human

Pathological State: Cancer

Cell Line: Macrophages

157
Multimodal single‐cell analysis reveals distinct radioresistant stem‐like and progenitor cell populations in murine glioma

J Alexander, QC LaPlant, SS Pattwell, F Szulzewsky, PJ Cimino, FP Caruso, P Pugliese, Z Chen, F Chardon, AJ Hill, C Spurrell, D Ahrendsen, A Pietras, LM Starita, D Hambardzumyan, A Iavarone, J Shendure, EC Holland

Glia (Wiley) USA, Italy, Sweden, 04 July 2020

Neuroscience

Key words: glioma, glioma stem cells, myeloid cells, radiation response, radioresistance, single‐cell RNA sequencing, SP analysis

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

158
Catching Common Cold Virus with a Net: Pyridostatin Forms Filaments in Tris Buffer That Trap Viruses—A Novel Antiviral Strategy?

A Real-Hohn, R Zhu, H Ganjian, N Ibrahim, P Hinterdorfer, H Kowalski, D Blaas

Viruses (MDPI) Austria, Sweden, 04 July 2020

Virology

Key words: Enterovirus, Rhinovirus, pyridostatin, filament, extracellular traps

Organism: Human

Cell Line: HeLa Cells

159
Fewer tumour-specific PD-1+ CD8+ TILs in high-risk “Infiltrating” HPV− HNSCC

K Xu, Y Fu, Y Han, R Xia, S Xu, S Duan, Z Zhang, J Li

British Journal of Cancer (Nature) China, 03 July 2020

Oncology

Key words: Head and neck cancer, Tumour immunology

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

160
Slug Is A Surrogate Marker of Epithelial to Mesenchymal Transition (EMT) in Head and Neck Cancer

TB Steinbichler, J Dudas, J Ingruber, R Glueckert, S Sprung, F Fleischer, N Cidlinsky, D Dejaco, B Kofler, AI Giotakis, II Skvortsova, H Riechelmann

Journal of Clinical Medicine (MDPI) Austria, 30 June 2020

Oncology

Key words: image cytometry, p16, p53, cancer stem cells, E-cadherin, β-catenin, EMT, head and neck cancer

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

161
Functional characterization of the basal amygdala-dorsal BNST pathway during contextual fear conditioning

JS Russell, S Trouche, LG Reijmers

eNeuro (Society for Neuroscience) USA, 29 June 2020

Neuroscience

Key words: contextual fear, fear memorybasal amygdala, bed nucleus of the stria terminalis, neural circuits, encoding, fear engram

Organism: Mouse

Tissue: Brain

162
Tissues derived from reprogrammed Wharton's jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus

CM Kong, A Subramanian, SU Gan, A Biswas, B Ariff, CY Fong

Stem Cell Research (Elsevier) Singapore, 26 June 2020

Stem Cell Research

Key words: Gestational diabetes mellitus, Induced pluripotent stem cells, Reprogramming, Wharton’s jelly stem cells, Pancreatic cells

Organism: Human

Cell Line: iPSCs

163
Comparison between paramagnetic and CD71 magnetic activated cell sorting of fetal nucleated red blood cells from the maternal blood

D Nemescu, D Constantinescu, V Gorduza, A Carauleanu, L Caba, DB Navolan

Journal of Clinical Laboratory Analysis (Wiley) Romania, 25 June 2020

Biological Methods

Key words: CD71, fluorescent in situ hybridization, magnetic‐activated cell sorting, nucleated red blood cells, prenatal diagnosis

Organism: Human

Cell Line: Blood

164
BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer

YC Hsu, CW Luo, WL Huang, CC Wu, CL Chou, CI Chen, SJ Chang, CY Chai, HC Wang, TY Chen, CF Li, MR Pan

Radiotherapy and Oncology (Elsevier) Taiwan, 24 June 2020

Radiotherapy, Oncology

Key words: BMI1, CCRT, Rectal cancers, Radioresistance

Organism: Human

Tissue: Colon

Pathological State: Cancer

165
The chemokine lymphotactin and its recombinant variants in oral cancer cell regulation

AZ Abdullah Zubir, SA Whawell, TS Wong, SA Khurram

Oral Diseases (Wiley) UK, 19 June 2020

Oncology

Key words: Cancer‐associated fibroblast, Lymphotactin, Oral squamous cell carcinoma, Tumour microenvironment, XCR1

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

166
p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection

H Ishida, A Kasajima, F Fujishima, R Akaishi, S Ueki, Y Yamazaki, Y Onodera, X Gao, H Okamoto, Y Taniyama, T Kamei, H Sasano

Virchows Archiv (Springer) Japan, Australia, Germany, 16 June 2020

Oncology

Key words: Esophagus Small-cell carcinoma, Poorly differentiated squamous cell carcinoma, Basaloid squamous cell carcinoma, p16, Human papillomavirus

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

167
Reciprocal Regulation Between Indoleamine 2, 3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells

HY Low, YC Lee, YJ Lee, HL Wang, YI Chen, PJ Chien, ST Li, WW Chang

Cancers (MDPI) Taiwan, 12 June 2020

Oncology, Stem Cell Research

Key words: IDO1, notch1, radiation, cervical cancer, cancer stem cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

168
Tumor Microenvironment Targeting Nano–Bio Emulsion for Synergistic Combinational X‐Ray PDT with Oncolytic Bacteria Therapy

W Park, S Cho, D Kang, JH Han, JH Park, B Lee, J Lee, DH Kim

Advanced Healthcare Materials (Wiley) South Korea, USA, 11 June 2020

Oncology, Nanomedicine

Key words: Bacteriolytic therapy, Nano–bio emulsions, Scintillating nanoparticles, Tumor microenvironments, X‐ray photodynamic therapy (PDT)

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

169
Regulatory T cells promote adipocyte beiging in subcutaneous adipose tissue

W Fang, Z Deng, F Benadjaoud, D Yang C Yang, GP Shi

The FASEB journal (Wiley) USA, China, 08 June 2020

Immunology

Key words: epididymal white adipose tissue, gonadal white adipose tissue, macrophage polarization, regulatory T cell, subcutaneous adipose tissue, uncoupling protein‐1

170
Yttrium-90 Radioembolization and Tumor Hypoxia: Gas-challenge BOLD Imaging in the VX2 Rabbit Model of Hepatocellular Carcinoma

AC Gordon, SB White, VL Gates, D Procissi, KR Harris, Y Yang, Z Zhang, W Li, T Lyu, X Huang, RA Omary, R Salem, RJ Lewandowski, AC Larson

Academic Radiology (Elsevier) USA, 07 June 2020

Radiotherapy, Oncology

Key words: Oxygenation, Hepatic radioembolization, Magnetic resonance imaging, Yttrium-90

Organism: Rabbit

Tissue: Kidney

Pathological State: Cancer

171
A prominent environmental endocrine disruptor, 4-nonylphenol, promotes endometriosis development via plasmacytoid dendritic cells

P Sharma, HH Tzeng, JYL Lee, EM Tsai, JL Suen

Molecular Human Reproduction (Oxford Academic) Taiwan, 04 June 2020

Reproductive Medicine

Key words: CD36, endometriosis, environmental endocrine disruptor, estrous cycle, IL-10, 4-nonylphenol, plasmacytoid dendritic cell

Organism: Mouse

Tissue: Uterus

Pathological State: Endometriosis

172
A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure

H Shawer, E Aiyelaagbe, C Clowes, SC Lean, Y Lu, KE Kadler, A Kerby, MR Dilworth, KE Hentges, AEP Heazell

PLoS One (PLOS) UK, 03 June 2020

Reproductive Medicine

Key words: Mouse models, Stillbirths, Embryos, Placenta, Fetal death, Myocardium, Heart, Giant cells

Organism: Mouse

Tissue: Placenta

173
GPRC5A reduction contributes to pollutant benzo [a] pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients

Z Huang, S Wang, Y Liu, L Fan, Y Zeng, H Han, H Zhang, X Yu, Y Zhang, D Huang, Y Wu, W Jiang, P Zhu, X Zhu, X Yi

Science of The Total Environment (Elsevier) China, 03 June 2020

Toxicology

Key words: Pulmonary fibrosis, GPRC5A, Benzo[a]pyrene pollution, Epithelium, Prognosis

Organism: Human

Tissue: Lung

Pathological State: Idiopathic non-specific interstitial pneumonia

174
AB0154 MERTK AND THE RESOLUTION OF INFLAMMATION IN IGG4-RELATED DISEASE

E Della Torre, L Rovati, A Monno, T Maehara, N Kaneko, M Lanzillotta, F Pedica, C Doglioni, S Pillai, A Manfredi

Annals of the Rheumatic Diseases (BMJ Journals) Italy, Japan, USA, 02 June 2020

Immunology

Organism: Human

Tissue: Tonsil

175
Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer

CS Lu, AL Shiau, BH Su, TS Hsu, CT Wang, YC Su, MS Tsai, YH Feng, YL Tseng, YT Yen, CL Wu, GS Shieh

Journal of Hematology & Oncology (Springer) Taiwan, 01 June 2020

Oncology

Key words: Lung cancer, Oct4, M2 macrophage, Tumor-associated macrophage, M-CSF

Organism: Human, Mouse

Tissue: Lung

Pathological State: Cancer

176
CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining

U Klinge, A Dievernich, R Tolba, B Klosterhalfen, L Davies

Journal of Biomedical Materials Research: Part B (Wiley) Germany, UK, 30 May 2020

Biological Materials

Key words: Fluorescence microscopy, Foreign body reaction, Lymphocyte, Macrophage, Mesh

Organism: Human

Tissue: Stomach

Pathological State: Abdominal Wall Hernia

177
CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease

Cory A Perugino, Naoki Kaneko, Takashi Maehara, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S Mahajan, Hang Liu, Emanuel Della-Torre, Samuel J H Murphy, Musie Ghebremichael, Zachary S Wallace, Marcy B Bolster, Liam M Harvey, Geetha Mylvaganam, Yesim Tuncay, Lloyd Liang, Sydney B Montesi, Xiuwei Zhang, Akira Tinju, Keita Mochizuki, Ryusuke Munemura, Mizuki Sakamoto, Masafumi Moriyama, Seiji Nakamura, Nir Yosef, John H Stone, Shiv Pillai

Journal of Allergy and Clinical Immunology (Mosby) USA, Japan, The Netherlands, Canada, China, Italy, 29 May 2020

Immunology

Key words: IgG4-RD, CD4+CTL, CD8+CTL, apoptosis, CD28lo, CD28(null)

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjogren syndrome

178
Caveolar communication with xenobiotic-stalled ribosomes compromises gut barrier integrity

SH Park, J Kim, Y Moon

Communications Biology (Nature) South Korea, 27 May 2020

Gastroenterology

Key words: Biomarkers, Cell Biology, Chemokines, Inflammation, Signal Transduction

Organism: Mouse

Tissue: Small Intestine

179
Interaction of different cell types with magnesium modified by plasma electrolytic oxidation

M Echeverry-Rendon, F Echeverria, MC Harmsen

Colloids and Surfaces B: Biointerfaces (Elsevier) Colombia, The Netherlands, 26 May 2020

Biological Materials

Key words: Magnesium, PEO, Adipose-derived stromal, ASC, Differentiation, Cytotoxicity

Organism: Human

Cell Line: HUVECs, ACSs

180
Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way

T Niedermair, S Schirner, RH Straub, S Grässel

Mechanisms of Ageing and  Development (Elsevier) Germany, 22 May 2020

Osteology

Key words: Bone, Osteoblast, Osteoclast, α-calcitonin gene-related peptide (α-CGRP), Osteopenia

Organism: Mouse

Tissue: Bone

181
KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation

RAF Gjaltema, D Goubert, C Huisman, C del Pilar Garcia Tobilla, M Koncz, PG Jellema, D Wu, U Brouwer, A Kiss, PJ Verschure, RA Bank, MG Rots

International Journal of Molecular Sciences (MDPI) The Netherlands, Hungary, 21 May 2020

Oncology

Key words: Pigenetic editing, KRAB, Gene repression, PLOD2, Fibrosis, Cancer

Organism: Human

Cell Line: Human skin fibroblasts

182
Synergistic effect of cell-derived extracellular matrix and topography on osteogenesis of mesenchymal stem cells

L Yang, L Ge, P van Rijn

ACS Applied Materials & Interfaces (ACS Publications) The Netherlands, 18 May 2020

Tissue Engineering

Key words: Extracellular matrix, Topography, Mesenchymal stem cells, Osteogenic differentiation, Mechanotransduction

Organism: Human

Cell Line: hBM-MSCs

183
Biomimetic Multiscale Hierarchical Topography Enhances Osteogenic Differentiation of Human Mesenchymal Stem Cells

L Yang, L Ge, Q Zhou, T Mokabber, Y Pei, R Bron, P van Rijn

Advanced Materials Interfaces (Wiley) The Netherlands, China, 13 May 2020

Stem Cell Research

Key words: collagen, extracellular matrix, hierarchical topography, human mesenchymal stem cells, mechanotransduction, osteogenic differentiation

Organism: Human

Cell Line:  hBM‐MSCs

184
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome

Kim L. Brunekreeft, Sterre T. Paijens, Maartje C.A. Wouters, Fenne L. Komdeur, Florine A. Eggink, Joyce M. Lubbers, Hagma H. Workel, Elisabeth C. Van Der Slikke, Noor E.J. Pröpper, Ninke Leffers, Julien Adam, Harry Pijper, Annechien Plat, Arjan Kol, Hans W. Nijman, Marco De Bruyn

OncoImmunology (Taylor & Francis) The Netherlands, France, Canada, 13 May 2020

Oncology, Immunology

Key words: Epithelial ovarian cancer, chemotherapy, tumor microenvironment, cancer immunology, MHC-I

Organism: Human

Tissue: Ovaries, Lymphoid Tissue

Pathological State: Cancer

185
Progesteron receptor expression in insulin producing cells of neuroendocrine neoplasms

T Tachibana, A Kasajima, T Aoki, T Tabata, K McNamara, S Yazdani, S Satoko, F Fujishima, F Motoi, M Unno, H Sasano

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Japan, Germany, 11 May 2020

Endocrinology

Key words: Neuroendocrine neoplasm, Insulinoma, Progesteron receptor

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

186
Decoupling the Amplitude and Wavelength of Anisotropic Topography and the Influence on Osteogenic Differentiation of Mesenchymal Stem Cells Using a High-Throughput Screening Approach

L Yang, L Ge, Q Zhou, K Jurczak, P van Rijn

ACS Applied Bio Materials (ACS Publications) The Netherlands, China, 06 May 2020

Stem Cell Research

Organism: Human

Cell Line: hBM-MSCs

187
Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program

Massimo Granai, Lucia Mundo, Ayse U. Akarca, Maria Chiara Siciliano, Hasan Rizvi, Virginia Mancini, Noel Onyango, Joshua Nyagol, Nicholas Othieno Abinya, Ibrahim Maha, Sandra Margielewska, Wenbin Wi, Michele Bibas, Pier Paolo Piccaluga, Leticia Quintanilla-Martinez, Falko Fend, Stefano Lazzi, Lorenzo Leoncini, Teresa Marafioti

Infectious Agents and Cancer (BMC) Italy, Germany, UK, Kenya, Egypt,, 06 May 2020

Oncology, Virology

Key words: Burkitt lymphoma, Tumour microenvironment, EBV, PD-L1, Immunotherapy, Immune checkpoint

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

188
High‐Throughput Screening and Hierarchical Topography‐Mediated Neural Differentiation of Mesenchymal Stem Cells

L Yang, KM Jurczak, L Ge, P van Rijn

Advanced Healthcare Materials (Wiley Online Library) The Netherlands, 04 May 2020

Stem Cell Research

Key words: anisotropic topography, hierarchical structures, high‐throughput screening, human mesenchymal stem cells, neural differentiation

Organism: Human

Cell Line: hMSCs

189
The Prognostic and Predictive Value of SOX2+ Cell Densities in Patients Treated for Colorectal Cancer

TJ Miller, MJ McCoy, TF Lee-Pullen, CC Anyaegbu, C Hemmings, MK Bulsara, CF Platell

Cancers (MDPI) Australia, 29 April 2020

Oncology

Key words: SOX2, colorectal cancer, chemotherapy, prognosis, oxaliplatin, 5-fluorouracil, cancer stem cell

Organism: Human

Tissue: Colon

Pathological State: Cancer

190
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research

Talita Glaser, Hiromi Shimojo, Deidiane Elisa Ribeiro, Patrícia Pereira Lopes Martins, Renata Pereira Beco, Michal Kosinski, Vanessa Fernandes Arnaud Sampaio, Juliana Corrêa-Velloso, Ágatha Oliveira-Giacomelli, Claudiana Lameu, Ana Paula de Jesus Santos, Héllio Danny Nóbrega de Souza, Yang D. Teng, Ryoichiro Kageyama & Henning Ulrich

Molecular Psychiatry (Nature) Japan, Brazil, USA, Poland, 29 April 2020

Cell Biology, Neuroscience

Key words: Cell biology, Diseases, Molecular biology, Neuroscience

Organism: Mouse

Cell Line: E14Tg2A cells

191
Acute Effects of Pulmonary Exposure to Zinc Oxide Nanoparticles on Brain in Vivo 2

HC Chuang, YT Yang, HC Chen, YH Hwang, KY Wu, TF Chen, CL Chen, MK Jhan, TJ Cheng

Aerosol and Air Quality Research (AAQR) Taiwan, 25 April 2020

Nanomedicine

Key words: Autophagy, Central nervous system, Elevated plus maze, Morris water maze, Nanoparticle, Ubiquitin.

Organism: Rat

Tissue: Brain

192
A characteristic expression pattern of core circadian genes in the diurnal tree shrew

PH Luo, YM Shu, RJ Ni, YJ Liu, JN Zhou

Neuroscience (Elsevier) China, 25 April 2020

Neuroscience

Key words: tree shrew, diurnal animal, circadian gene, brain rhythm, peripheral rhythm

Organism: Tree Shrew

Tissue: Brain

193
In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique

SC Liao, CY Chen, YH Hsu, CT Li, CC Hsieh, MS Tsai, MY Chan, CH Lee, SH Wang, SK NG, HK Tsou, WY Wu

Surface and Coatings Technology (Elsevier) Taiwan, 21 April 2020

Biological Materials

Key words: HiPIMS, TiN, Acrylamide crosslinking, BMP2 attachment, in vitro and in vivo studies

Organism: Mouse

Tissue: Skin

194
Characterization of CD103+ CD8+ tissue‑resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti‑PD‑1 blockade

L Han, QL Gao, XM Zhou, C Shi, GY Chen, YP Song, YJ Yao, YM Zhao, XY Wen, SL Liu, YM Qi, YF Gao

Cancer Immunology, Immunotherpay (Springer) China, 20 April 2020

Oncology, Immunology

Key words: CD103, Tissue-resident T cells,Tumor-infiltrating lymphocytes, Esophageal squamous cell carcinoma

Organism: Mouse

Tissue: Skin

Pathological State: Cancer

195
The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos

ZY Chen, NJ Li, FY Cheng, JF Hsueh, CC Huang, FI Lu, TF Fu, SJ, Yan, YH Lee, YJ Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 20 April 2020

Nanomedicine

Key words: zebrafish embryos, acute toxicity, silver nanoparticles, chorion pore size, lysosomal activity, apoptosis

Organism: Zebrafish

Tissue: Whole Organism

196
Macrophages and Fibroblasts Differentially Contribute to Tattoo Stability

H Strandt, O Voluzan, T Niedermair, U Ritter, J Thalhamer, B Malissen, A Stoeklinger, S Henri

Dermatology (Karger) France, Germany, 19 April 2020

Dermatology

Key words: Tattoo, Macrophage, Fibroblast, Tattoo maintenance

Organism: Human

Tissue: Skin

197
Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit

KH Kim, SJ Lee, J Kim, Y Moon

iScience (Cell Press) South Korea, 18 April 2020

Cell Biology

Key words: CTGF/CCN2, Wnt, Ribosomal insult, Colorectal cancer, Tumor niche

Organism: Human

Cell Line: HCT8 and HCT116 cells

198
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma

JR Podojil, AP Glaser, D Baker, ET Courtois, D Fantini, Y Yu, V Eaton, S Sivajothi, M Chiang, A Das, KA McLauglin, P Robson, SD Miller, JJ Meeks

OncoImmunology (Taylor & Francis) USA, 16 April 2020

Oncology, Immunology

Key words: Immunotherapy, bladder cancer, macrophage, T cell, checkpoint inhibitor

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

199
Functional diversity between HSP70 paralogs due to variable interactions with specific co-chaperones.

D Serlidaki, MAWH van Waarde, L Rohland, AS Wentink, SL Dekker, MJ Kamphuis, JM Boertien, JF Brunsting, NB Nillegoda, B Bukau, MP Mayer, HH Kampinga, S Bergink

Journal of Biological Chemistry (ASBMB) The Netherlands, Germany, 13 April 2020

Cell Biology

Key words: Hsp110 ,HSPA4, HSPH2, protein folding, superoxide dismutase (SOD), 70 kilodalton heat shock protein (Hsp70), proteostasis amyotrophic lateral sclerosis (ALS) (Lou Gehrig disease), heat shock protein (HSP)

Organism: Human

Cell Line: HEK293 Cells

200
IFN-κ suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis

Y He, W Fu, K Cao, Q He, X Ding, J Chen, L Zhu, T Chen, L Ding, Y Yang, C Zhu, S Yuan, Z Li, C Zhao, X Zhang, J Xu

Science Signaling (AAAS) China, 07 April 2020

Immunology

Organism: Mouse

Tissue: Lung

Contact

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

Please enable the javascript to submit this form

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies).
You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.