Customer Publications (A total of 2312 papers published)
Hierarchical Multiplexing Nanodroplets for Imaging-Guided Cancer Radiotherapy via DNA Damage Enhancement and Concomitant DNA Repair Prevention
ACS NANO (ACS Publications) China, 29 May 2018
Nanomedicine
Key words: cancer radiotherapy, DNA damage and repair, hierarchical nanostructure, multimodal imaging, tumor hypoxia [more]
Organism: Mouse
Tissue: Allograft Tumor
Pathological State: Cancer
Acellular vascular matrix grafts from human placenta chorion: Impact of ECM preservation on graft characteristics, protein composition and in vivo performance
Biomaterials (Elsevier) Austria, 29 May 2018
Regenerative Medicine
Key words: Decellularized matrix, Human placenta, Small diameter vascular grafts, Cell migration, Biocompatibility [more]
Organism: Human
Tissue: Placenta
Identification of galectin-3 as an autoantigen in patients with IgG4-related disease
Journal of Allergy and Clinical Immunology (Elsevier) UK, USA, Italy, 29 May 2018
Immunology
Key words: IgG4-related disease, plasmablast, autoantigen, galectin-3, autoantibody [more]
Organism: Human
Tissue: Pancreas
Pathological State: IgG4-Related Disease
Allocation of Interferon Gamma mRNA Positive Cells in Caecum Hallmarks a Protective Trait Against Histomonosis
Frontiers in Immunology (Frontiers Media S.A.) Austria, 28 May 2018
Immunology
Key words: Histomonas meleagridis, histomonosis, image analysis, immunofluorescence, in situ hybridization, interferon gamma, interleukin-13, vaccination [more]
Organism: Turkey, Chicken
Tissue: Small Intestine, Liver, Spleen
Pathological State: Histomonosis
The overexpression of Fra1 disorders the inflammatory cytokine secretion by mTEC of myasthenia gravis thymus
Scandinavian journal of Immunology (Blackwell Publishing Inc.) China, 28 May 2018
Neuroscience
Key words: Fos-related antigen-1, inflammatory cytokine, medulla thymic epithelial cells, myasthenia gravis [more]
Organism: Human
Tissue: Thymus
Pathological State: Myasthenia Gravis
Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke
CNS Neuroscience and Therapeutics (Wiley) The Netherlands, 27 May 2018
Neuroscience
Key words: PET imaging, neuroinflammation, nutrition, photothrombotic stroke [more]
Organism: Rat
Tissue: Brain
Pathological State: Cerebral Ischemia
Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI-PEG20 treatment in CCA cell lines
Oncology Letters (Spandidos Publications) Thailand, 24 May 2018
Oncology
Key words: Ki-67, arginine deprivation, argininosuccinate synthetase, cholangiocarcinoma, pegylated arginine deiminase [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
Cell Line: Cholangiocarcinoma cell lines (RmCCA-1 and HuCCA), human fibroblast cell line (BJ-1)
Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway
Cell Death Discovery (Nature) South Korea, USA, 23 May 2018
Oncology
Organism: Human
Pathological State: Cancer
Cell Line: SKOV-3 cells
BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling
Laboratory Investigation (Nature) Taiwan, 22 May 2018
Hepathology
Key words: BMP-2, liver fibrosis, TGF-β1 signaling [more]
Organism: Human
Tissue: Liver
Pathological State: Liver Fibrosis, Liver Cirrhosis
Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis
Frontiers in Pharmacology (Frontiers Media S.A.) Brazil, 18 May 2018
Oncology
Key words: bone marrow, bradykinin, metastasis, neuroblastoma, purinergic system [more]
Organism: Human
Pathological State: Cancer
Cell Line: CHP-100 cells
Lactobacillus casei Variety rhamnosus Probiotic Preventively Attenuates 5-Fluorouracil/Oxaliplatin-Induced Intestinal Injury in a Syngeneic Colorectal Cancer Model
Frontiers in Microbiology (Frontiers Media S.A.) Taiwan, 15 May 2018
Oncology
Key words: FOLFOX, Lactobacillus, apoptosis, gut microbiota, intestinal mucositis [more]
Organism: Mouse
Tissue: Allograft Tumor
Pathological State: Cancer
Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice
Biomedicine & Pharmacotherapy (Elsevier) China, 14 May 2018
Oncology
Key words: Gastric cancer, Catalpol, Migration, Apoptosis and ROS, DDP [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment
Cancer Cell (Cell Press) USA, 14 May 2018
Oncology
Key words: Olig2, Wnt, angiogenesis, astrocyte, blood-brain barrier, glioma, invasiveness, oligodendrocyte precursor, p53, vessel co-option [more]
Organism: Human, Mouse
Tissue: Brain, Xenograft Tumor
Pathological State: Cancer
Hematological findings in non-treated and gamma-irradiated mice deficient for MIC-1/GDF15.
Physiological Research (BioMed Central) Czech Republic, 10 May 2018
Hematology
Key words: GDF15 knockout mice, hematopoiesis, ionizing radiation, stress-induced cytokine [more]
Organism: Mouse
Tissue: Spleen, Bone
DNA damage predicts prognosis and treatment response in colorectal liver metastases superior to immunogenic cell death and T cells
Theranostics (Ivyspring International Publisher) Austria, 10 May 2018
Oncology
Key words: DNA damage, calreticulin, immunogenic cell death, colorectal liver metastases [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Regorafenib inhibits tumor progression through suppression of ERK/NF-κB activation in hepatocellular carcinoma bearing mice
Bioscience Reports (Kluwer Academic Publishers) Taiwan, 05 May 2018
Oncology
Key words: Bioluminescence imaging, Regorafenib, apoptosis, hepatocellular carcinoma, nuclear factor kappaB [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Effects of chitosan and chitosan N-acetylcysteine solutions on conjunctival epithelial cells
Journal of EuCornea (Elsevier) Austria, Serbia, 02 May 2018
Ophthalmology
Key words: Chitosan Chitosan-N-acetylcysteine Uptake Conjunctival epithelial cells Drug delivery [more]
Organism: Guinea Pig
Tissue: Eye
Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor‐suppressing phenotype
International Journal of Cancer (Wiley) Taiwan, 01 May 2018
Oncology
Key words: Rab37, ST2, exocytosis, macrophage, tumor microenvironment [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the Akt‑GSK3β and MAPK/ERK signaling cascades
Oncology Reports (Demetrios A. Spandidos Ed. and Pub.) China, 23 April 2018
Oncology
Key words: Eupatilin, human esophageal cancer, TE1 cells, Akt‑GSK3β, MAPK/ERK [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1
Molecular Immunology (Elsevier) Taiwan, 23 April 2018
Immunology
Key words: Allograft tolerance, B lymphocyte-induced maturation protein, T cells [more]
Organism: Mouse
Tissue: Skin
Pathological State: Allogeneic Transplantation
IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury
Experimental & Molecular Medicine (Nature) Taiwan, 20 April 2018
Nephrology
Key words: IL-33/ST2 axis, hyperplasia, renal injury, unilateral ureteral obstruction (UUO) [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Acute Kidney Injury
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
CELL (Cell Press) UK, 19 April 2018
Oncology
Key words: branched evolution, cancer evolution, chromosome instability, deterministic evolution, intratumor heterogeneity, linear evolution, metastasis, punctuated evolution, renal cell cancer, tumor diversity [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Tumor-induced generation of splenic erythroblast-like Ter-cells promotes tumor progression
CELL (Cell Press) China, 19 April 2018
Oncology
Key words: Ter-119, Ter-cell, artemin, cancer immunotherapy, erythroblast-like, hepatocellular carcinoma, prognosis biomarker [more]
Organism: Mouse
Tissue: Liver
Pathological State: Cancer
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
CELL (Cell Press) UK, 19 April 2018
Oncology
Key words: chromosome instability, cytoreductive nephrectomy, evolution of metastasis, loss of 9p, metastasectomy, metastasis, oligometastasis, renal cell cancer, solitary metastasis [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Conditional depletion of GSK3b protects oligodendrocytes from apoptosis and lessens demyelination in the acute cuprizone model
GLIA (Wiley) USA, 18 April 2018
Neuroscience
Key words: GSK3b, cell death, glia, multiple sclerosis [more]
Organism: Mouse
Tissue: Brain
CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer
Experimental & Molecular Medicine (Elsevier) UK, 11 April 2018
Oncology
Key words: CD10, NEP, CALLA, Colorectal cancer, Epithelial-mesenchymal transition, Metastasis [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma
Genes and Development (Cold Spring Harbor Laboratory Press) USA, 09 April 2018
Oncology
Key words: glioblastoma, HoxA, homeobox RCAS, chromosome 7 gain [more]
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
Photodynamic Effect of Methylene Blue and Low Level Laser Radiation in Head and Neck Squamous Cell Carcinoma Cell Lines
International Journal of Molecular Sciences (MDPI) Austria, 07 April 2018
Oncology
Key words: TissueFaxs, head and neck carcinoma, methylene blue, photodynamic therapy [more]
Organism: Human
Pathological State: Cancer
Cell Line: Detroit 562 cells (pharynx carcinoma)
The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivo
Life Science () USA, Japan, 05 April 2018
Immunology
Key words: T follicular helper (TFH), BATF+, IgG4 class switching, Sjögren’s syndrome, secondary lymphoid organs [more]
Organism: Human
Tissue: Salivary Gland
Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice
Frontiers in Physiology (Frontiers Media S.A.) Germany, 04 April 2018
Physiology
Key words: endothelial cells, spider veins, venous hypertension, venous remodeling, wall stress [more]
Organism: Human
Cell Line: HUVEC, HUVSMC (human umbilical vein endothelial and SMCs)
Cordyceps militaris Extract Inhibits the NF-κB pathway and Induces Apoptosis through MKK7-JNK Signaling Activation in TK-10 Human Renal Cell Carcinoma
Natural Product Communications (SAGE Journals) South Korea, 01 April 2018
Oncology
Key words: Cordyceps militaris, Apoptosis, NF-κB, MKK7, JNK, TK-10 [more]
Organism: Human
Pathological State: Cancer
Cell Line: TK-10 renal cancer cell lines
Amentoflavone enhances the therapeutic efficacy of sorafenib by inhibiting anti-apoptotic potential and potentiating apoptosis in hepatocellular carcinoma in vivo
Anticancer Research (International Institute of Anticancer Research) Taiwan, 01 April 2018
Oncology
Key words: Amentoflavone sorafenib hepatocellular carcinoma ERK AKT apoptosis [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Periostin antisense oligonucleotide suppresses bleomycin‐induced formation of a lung premetastatic niche for melanoma
Cancer Science (Wiley) Japan, 31 March 2018
Oncology
Key words: antisense oligonucleotide, lung fibrosis, melanoma, periostin, premetastatic niche [more]
Organism: Mouse
Tissue: Lung
MRI‐guided interventional natural killer cell delivery for liver tumor treatment
Cancer Medicine (Wiley) USA, 30 March 2018
Oncology
Key words: Adoptive transfer immunotherapy, hepatocellular carcinoma, interventional oncology, magnetic resonance imaging, natural killer cell [more]
Organism: Rat
Tissue: Liver
Pathological State: Cancer
Collagen morphology influences macrophage shape and marker expression in vitro
Journal of Immunology and Regenerative Medicine (Elsevier) The Netherlands, 30 March 2018
Immunology
Key words: Extracellular matrix, Collagen type I, Pulmonary fibrosis, Ym1, CD206, Migration [more]
Organism: Human
Cell Line: Alveolar-like Makrophhages
Olaparib is effective in combination with, and as maintenance therapy after, first‐line endocrine therapy in prostate cancer cells
Molecular Oncology (Wiley) Austria, 15 March 2018
Oncology
Key words: PARP inhibition, combination therapy, endocrine therapy, maintenance therapy, olaparib, prostate cancer [more]
Organism: Human
Pathological State: Cancer
Cell Line: LNCaP-abl (Prostate carcinoma cell lines)
Loss of Neuroglobin Expression Alters Cdkn1a/Cdk6-Expression Resulting in Increased Proliferation of Neural Stem Cells
Stem Cells and Development (Mary Ann Liebert Inc.) Belgium, Germany, 15 March 2018
Stem Cell Research
Key words: neuroglobin – cell cycle – transcriptomics – neural stem cells [more]
Organism: Mouse
Cell Line: Neural stem cells
Effects of iota-carrageenan on ocular Chlamydia trachomatis infection in vitro and in vivo
Journal of Applied Phycology (Kluwer Academic Publishers) Austria, 13 March 2018
Microbiology
Key words: Carrageenan, Trachoma, Natural products, Chlamydia [more]
Organism: Human
Pathological State: Chlamydia Infection
Cell Line: HCjE cells (human corneal-limbal and conjunctival epithelial cell line)
Prostaglandin E2 Is Required for BMP4-Induced Mesoderm Differentiation of Human Embryonic Stem Cells
Stem Cell Reports (Cell Press) China, 13 March 2018
Stem Cell Research
Key words: prostaglandin E2, cyclooxygenase-1, BMP4, mesoderm, differentiation, human embryonic stem cells, β-catenin, [more]
Organism: Human
Cell Line: WA01 and WA09 hESCs
Atlas of the Striatum and Globus Pallidus in the Tree Shrew: Comparison with Rat and Mouse
Neuroscience Bulletin (Springer) China, 05 March 2018
Neuroscience
Key words: Striatum, Globus pallidus, Basal ganglia, Reconstruction, Rodent, Parvalbumin [more]
Organism: Tree Shrew
Tissue: Brain
Novel platforms of multiplexed immunofluorescence for study of paraffin tumor tissues
Journal of Cancer Treatment and Diagnosis (Sciaccess Publishers) USA, 01 March 2018
Cytometry
Key words: Multiplexed proteins identification Immunofluorescence Signal Amplification Spatial Cell Distribution Image Analysis
4:20 PM Abstract No. 350 Interferon-gamma-eluting microspheres for MRI-guided immunotherapy of liver cancer
Journal of Vascular and Interventional Radiology (Elsevier) USA, 01 March 2018
Oncology
Organism: Rabbit
Tissue: Liver
Pathological State: Cancer
In vitro behavior of human mesenchymal stem cells on poly(N-isopropylacrylamide) based biointerfaces obtained by matrix assisted pulsed laser evaporation
Applied Surface Science (Elsevier) Romania, 28 February 2018
Cell Biology
Key words: pNIPAM coatings, MAPLE, mesenchymal stem cells [more]
Organism: Human
Cell Line: Human mesenchymal stem cells (hMSCs)
[18F]FEPPA: Improved Automated Radiosynthesis, Binding Affinity, and Preliminary in Vitro Evaluation in Colorectal Cancer
ACS Medicinal Chemistry Letters (ACS Publications) Austria, 21 February 2018
Radiotherapy
Key words: Affinity, autoradiography, colorectal cancer, FEPPA, radiosynthesis, TSPO [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
CXCL5 facilitates melanoma cell-neutrophil interaction and lymph node metastasis
Journal of Investigative Dermatology (Elsevier) Austria, 21 February 2018
Dermatology
Key words: CXCL5, melanoma cells, chemokine mRNA expression [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain
Molecular Neurobiology (Springer) Taiwan, 19 February 2018
Neuroscience
Key words: Neonatal brain injury, neurovascular protection, hypoxia-preconditioned, human umbilical vein endothelial cells, hypoxia-inducible factor 1-alpha [more]
Organism: Human
Cell Line: HUVECs (Human umbilical vein endothelial cells)
Inflammatory Monocytes Drive Influenza A Virus–Mediated Lung Injury in Juvenile Mice
The Journal of Immunology (American Association of Immunologists) USA, 14 February 2018
Immunology
Key words: Influenza A virus (IAV), NLRP3 inflammasome, cytokines, monocytes [more]
Organism: Mouse
Tissue: Lung, Heart
Preclinical In Vitro and In Vivo Evaluation of [18F]FE@SUPPY for Cancer PET Imaging: Limitations of a Xenograft Model for Colorectal Cancer
Contrast Media and Molecular Imaging (Wiley) Austria, 13 February 2018
Oncology
Key words: [18F]FE@SUPPY, Cancer PET Imaging, Colorectal Cancer [more]
Organism: Mouse
Tissue: Colon
Pathological State: Cancer
Calcium signaling mediates five types of cell morphological changes to form neural rosettes
Journal of Cell Science (The Company of Biologists) Czech Republic, 12 February 2018
Neuroscience
Key words: Embryonic stem cells, neural stem cell niche, neural rosette formation, calcium, neurogenesis, adherens junctions, cytoskeleton proteins [more]
Organism: Human
Cell Line: Human ESC-derived neural rosettes
Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers
Scientific Reports (Nature) Japan, 02 February 2018
Oncology
Key words: Gastric cancer, p53 mutations, tumour-suppressor proteins [more]
Organism: Mouse
Tissue: Stomach
Pathological State: Cancer
Angiogenin Attenuates Scar Formation in Burn Patients by Reducing Fibroblast Proliferation and Transforming Growth Factor β1 Secretion
Annals of Plastic Surgery (LWW Journals) Taiwan, 01 February 2018
Regenerative Medicine
Key words: angiogenin, fibroblast, scar, Smad2, transforming growth factor β1 [more]
Organism: Human
Tissue: Skin
Pathological State: Burn Wound
Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of “luminal” muscle-invasive bladder cancers
Molecular Carcinogenesis (Wiley) UK, 01 February 2018
Oncology
Key words: Urothelium, carcinogens, normal human urothelial (NHU) cells, EROD activity [more]
Organism: Human
Cell Line: NHU cells (Normal human urothelial)
Grey matter OPCs are less mature and less sensitive to IFNγ than white matter OPCs: consequences for remyelination
Scientific Reports (Nature) The Netherlands, 01 February 2018
Neuroscience
Key words: Multiple sclerosis (MS), central nervous system, oligodendrocyte progenitor cells (OPCs) [more]
Organism: Rat
Cell Line: OPS cells (Oligodendrocyte progenitor cells)
Assessing the selective therapeutic efficacy of superparamagnetic erlotinib nanoparticles in lung cancer by using quantitative magnetic resonance imaging and a nuclear factor kappa-B reporter gene system
Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier) Taiwan, 31 January 2018
Nanomedicine
Key words: Erlotinib, superparamagnetic iron oxide, magnetic resonance imaging, nuclear factor-κBNon-small-cell lung cancer [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Expression of cystatin C in the female reproductive tract and its effect on human sperm capacitation
Reproductive Biology and Endocrinology (Springer) Taiwan, 30 January 2018
Reproductive Medicine
Key words: Cystatin C (CST3), seminal plasma, sperm protein tyrosine phosphorylation [more]
Organism: Human
Tissue: Uterus
SPK1-transfected UCMSC has better therapeutic activity than UCMSC in the treatment of experimental autoimmune encephalomyelitis model of Multiple sclerosis
Scientific Reports (Nature) China, 29 January 2018
Neuroscience
Key words: Multiple Sclerosis (MS), central nervous system, permanent neurological damage, cytokine [more]
Organism: Human
Cell Line: Human umbilical cord mesenchymal stem cells (HUC-MSC-SPK1)
AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling
Nature Microbiology (Nature) China, 29 January 2018
Microbiology
Key words: Zika virus (ZIKV), neonatal microcephaly, Guillain–Barré syndrome, AXL [more]
Organism: Mosquito
Pathological State: Zika Virus Infection, Guillain–Barré syndrome
Cell Line: C6/36 cells
Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis
Mucosal Immunology (Nature) USA, 24 January 2018
Immunology
Organism: Mouse
Tissue: Colon
Pathological State: Colitis
Injectable hydroxyphenyl derivative of hyaluronic acid hydrogel modified with RGD as scaffold for spinal cord injury repair
Journal of Biomedical Materials Research (Wiley) Czech Republic, 23 January 2018
Regenerative Medicine
Key words: Hydrogel, spinal cord injury (SCI), hydroxyphenyl derivative of hyaluronic acid (HA-PH) [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells
Scientific Reports (Nature) USA, 22 January 2018
Oncology
Key words: Pancreatic cancer (PC), CCR5, CCL5, F-actin polymerization [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet
Journal of Cerebral Blood Flow and Metabolism (SAGE Journals) USA, 19 January 2018
Oncology
Key words: Animal models, hypertension, posterior cerebral reversible encephalopathy, cerebral blood flow, white matter [more]
Organism: Rat
Tissue: Brain
Pathological State: Encephalopathy
Simvastatin induces G1 arrest by up-regulating GSK3β and down-regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells
Journal of Cellular Physiology (Wiley) Taiwan, 15 January 2018
Oncology
Key words: Simvastatin (SIM), colorectal cancer (CRC), CDK4/cyclin D1 [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Canine macrophages can like human macrophages be in vitro activated toward the M2a subtype relevant in allergy
Developmental & Comparative Immunology (Elsevier) Austria, 10 January 2018
Immunology
Key words: Allergy, canine, comparative, DH82M1 macrophage, M2a macrophage, polarization [more]
Organism: Dog, Human
Pathological State: Cancer
Cell Line: U937 and DH82 cells (Makrophage like cells)
Formation of nanotubular TiO2 structures with varied surface characteristics for biomaterial applications
Journal of Biomedical Materials Research (Wiley) Colombia, 09 January 2018
Biological Materials
Key words: Anodization, titanium, nanotubular TiO2, counterion [more]
Organism: Human
Cell Line: Adipose tissue derived stromal cells (ADSC)
Physical-chemical characterization and biological assessment of simple and lithium-doped biological-derived hydroxyapatite thin films for a new generation of metallic implants
Applied Surface Science (Elsevier) Romania, Turkey, 06 January 2018
Regenerative Medicine
Key words: Biological-derived hydroxyapatite, Lithium doping, Pulsed Laser Deposition, Sustainable resources, In vitro assessment [more]
Organism: Human
Cell Line: Human mesenchymal stem cells (hMSCs)
Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?
Neural Regeneration Research (Publishing House of Neural Regeneration Research) Czech Republic, USA, 01 January 2018
Regenerative Medicine
Key words: spinal cord injury, epigallocatechin gallate, curcumin, inflammatory response, neural regeneration [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Zinc finger protein 143 expression is closely related to tumor malignancy via regulating cell motility in breast cancer
BMB Reports (NCBI) South Korea, 31 December 2017
Oncology
Key words: Invasive ductal carcinoma, Metastasis, Motility, ZNF143 [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
AKT3 drives adenoid cystic carcinoma development in salivary glands
Cancer Medicine (Wiley) Austria, 28 December 2017
Oncology
Key words: AKT3, adenoid cystic carcinoma, MMTV-tTA mouse model, oncogene addiction, salivary gland cancer [more]
Organism: Mouse
Tissue: Salivary Gland
Pathological State: Cancer
A benchmark for comparing precision medicine methods in thyroid cancer diagnosis using tissue microarrays
Bioinformatics (Oxford University Press) Taiwan, USA, Japan, 23 December 2017
Biological Methods
Key words: precision medicine, cancer diagnosis, tissue microarray [more]
Organism: Human
Tissue: Thyroid
Pathological State: Cancer
Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways
Oncotarget (Impact Journals) China, 22 December 2017
Oncology
Key words: human bladder cancer, Actein (ACT), autophagy and apoptosis, ROS and JNK, AKT [more]
Organism: Mouse, Human
Tissue: Xenograft Tumor, Liver, Lung, Kidney
Pathological State: Cancer
Recurrent infection progressively disables host protection against intestinal inflammation
Science (American Association for the Advancement of Science) USA, Germany, 22 December 2017
Immunology
Key words: Recurrent infection, host protection, intestinal inflammation [more]
Organism: Mouse
Tissue: Small Intestine, Colon
Pathological State: Intestinal Inflammation
CD151, A Novel Host Factor of Nuclear Export Signaling in Influenza Virus Infection
Journal of Allergy and Clinical Immunology (Elsevier) Singapore, 21 December 2017
Immunology
Key words: Influenza A virus (IAV), CD151, nuclear export, host innate immunity, inflammasome, IAV severity [more]
Organism: Mouse
Tissue: Lung
Pathological State: Influenza Infection
Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy
BMC Immunology (BioMed Central) Germany, 19 December 2017
Immunology
Key words: Donor specific antibodies, humoral rejection, renal transplantation, non-adherence, leukocyte infiltration, BAFF [more]
Organism: Rat
Tissue: Kidney
Pathological State: Organ Transplantation
Mitochondrial ROS activates ERK/autophagy pathway as a protected mechanism against deoxypodophyllotoxin-induced apoptosis
Oncotarget (Impact Journals) South Korea, USA, 19 December 2017
Oncology
Key words: Deoxypodophyllotoxin, apoptosis, autophagy, mitochondrial ROS, ERK [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Magnolol inhibits venous remodeling in mice
Scientific Reports (Nature) Germany, 19 December 2017
Cardiology
Key words: Magnolol, venous vasculature, endothelial cells, varicose/spider veins, peripheral vascular disease [more]
Organism: Human
Cell Line: HUVECs (Human umbilical vein endothelial cells)
TDP-43 proteolysis is associated with astrocyte reactivity after traumatic brain injury in rodents
Journal of Neuroimmunology (Elsevier) Taiwan, 15 December 2017
Neuroscience
Key words: Astrocyte, Astrogliosis, Traumatic brain injury, Transactivation response DNA-binding protein 43 [more]
Organism: Rat
Tissue: Brain
Pathological State: Traumatic Brain Injury
Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release
Nanomaterials (MDPI) Romania, 13 December 2017
Nanomedicine
Key words: hydrogel, clay, nanocomposites, biocompatibility [more]
Organism: Cattle
Cell Line: HT29 and MDBK cells
18F-FDG PET Biomarkers Help Detect Early Metabolic Response to Irreversible Electroporation and Predict Therapeutic Outcomes in a Rat Liver Tumor Model
Radiology (Radiological Society of North America) USA, China, 12 December 2017
Radiotherapy, Oncology
Key words: 18F-FDG PET, Biomarkers, Metabolic Response, Irreversible Electroporation, Liver Tumor [more]
Organism: Rat
Tissue: Liver
Pathological State: Cancer
Comparison of MOLLI, shMOLLLI, and SASHA in discrimination between health and disease and relationship with histologically derived collagen volume fraction
European Heart Journal (Oxford University Press) UK, Germany, Spain, 11 December 2017
Cardiology
Key words: T1 mapping, MOLLI, shMOLLI, SASHA, collagen, aortic valve stenosis, myocardium, troponin, myocardial fibrosis, collagen, respiratory care units, therapeutic equivalency, transverse spin relaxation time [more]
Organism: Human
Tissue: Heart
Pathological State: Cardiac Fibrosis
INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis
Oncotarget (Impact Journals) South Korea, 06 December 2017
Oncology
Key words: INO80 chromatin remodeling complex, colon cancer, APC Min mouse model, replication stress, apoptosis [more]
Organism: Mouse
Tissue: Small Intestine, Colon
Pathological State: Cancer
Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer
Scientific Reports (Nature) Taiwan, 05 December 2017
Oncology
Key words: Phosphorylation, cancer therapeutic resistance, Cdc7-Dbf4 kinase, stress [more]
Organism: Human
Tissue: Mucosa
Pathological State: Cancer
Nocturnal resveratrol administration inhibits chemically induced breast cancer formation in rats
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (Polish Physiological Society) Slovakia, Austria, 01 December 2017
Oncology
Key words: resveratrol, circadian rhythm, carcinogenesis, breast cancer, immunity, reactive oxygen species [more]
Organism: Rat
Tissue: Breast
Pathological State: Cancer
IgE autoreactivity in bullous pemphigoid: eosinophils and mast cells as major targets of pathogenic immune reactants
British Journal of Dermatology (Wiley) Austria, 28 November 2017
Dermatology
Key words: Bullous pemphigoid (BP), urticarial eruptions, IgG, IgE [more]
Organism: Human
Tissue: Skin
Pathological State: Bullous Pemphigoid
Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs)
Thrombosis Research (Elsevier) Austria, Germany, Norway, 21 November 2017
Cell Biology
Key words: NETs, FSAP, thrombosis, inflammation [more]
Organism: Human
Tissue: Blood Vessels
Analysis of anti-TNF-induced skin lesions reveals strong Th1 activation with some distinct immunological characteristics
British Journal of Dermatology (Wiley) Austria, USA, 16 November 2017
Dermatology
Key words: Psoriasiform, eczematous eruptions, anti-TNF-α therapy, IFN-γ [more]
Organism: Human
Tissue: Skin
Pathological State: Crohn's Disease, Colitis, Rheumatoid Arthritis, Psoriasis, Eczema
Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making
CELL (Cell Press) USA, 16 November 2017
Neuroscience
Key words: Striatum, basal ganglia, cost-benefit, prefrontal cortex, optogenetics, prelimbic cortex, parvalbumin-positive interneurons, fast-spiking interneuron, sexcitation-inhibition balance [more]
Organism: Rat
Tissue: Brain
Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation
British Journal of Cancer (Nature) UK, 14 November 2017
Oncology
Key words: Phospholipases, mTOR, PKB/Akt, prostate cancer (PCa), benign prostatic hyperplasia (BPH) [more]
Organism: Human
Tissue: Kidney, Prostate
Pathological State: Cancer
Controlled release of liposome-encapsulated temozolomide for brain tumour treatment by convection-enhanced delivery
Journal of Drug Targeting (Taylor and Francis) Taiwan, 14 November 2017
Oncology
Key words: Convention-enhanced delivery, drug delivery, liposome, temozolomide, brain tumour [more]
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways
Infection and Immunity (American Society for Microbiology) USA, 13 November 2017
Immunology
Key words: Vibrio cholerae infection, cholera, Caco-2 or THP-1 cells [more]
Organism: Human
Tissue: Small Intestine
Pathological State: Cholera
Digital image analysis in breast pathology—from image processing techniques to artificial intelligence
Translational Research (Elsevier) Sweden, 07 November 2017
Oncology
Key words: Breast cancer, histopathology, biomarker, artificial intelligence (AI) [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Cyclin D1 promoter -56 and -54 bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen’s disease
Journal of Dermatological Science (Elsevier) Taiwan, 31 October 2017
Oncology
Key words: Arsenic-induced Bowen’s disease, cyclin D1 un-methylation, aneuploidy, predictor, invasive progression [more]
Organism: Human
Tissue: Skin
Pathological State: Bowen's Disease, Cancer
HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues
Histopathology (Wiley) UK, 27 October 2017
Medical Image Analysis
Key words: Human epidermal growth factor receptor 2 (HER2), IHC, invasive breast cancer (BCa)
CCR7 Is Important for Mesangial Cell Physiology and Repair
Journal of Histochemistry & Cytochemistry (SAGE Journals) Germany, 27 October 2017
Oncology
Key words: Homeostatic chemokine receptor CCR7, human mesangial cells, glomerulogenesis, mesangial biology [more]
Organism: Mouse
Tissue: Kidney
Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion
Cell Death & Disease (Nature) China, 26 October 2017
Oncology
Key words: Guanylate-binding protein 2 (GBP2), interferon-γ (IFN-γ), mitochondrial fission, shRNA [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
The Pericytic Phenotype of Adipose Tissue-derived Stromal Cells is Promoted by NOTCH2
Stem Cells (Wiley) Germany, The Netherlands, 25 October 2017
Stem Cell Research
Key words: Diabetic retinopathy (DR), adipose tissue‐derived stromal cells (ASC), NOTCH2, human umbilical cord vein endothelial cells (HUVEC) [more]
Organism: Human
Cell Line: HUVECs (Human umbilical vein endothelial cells)
The natural compound 2,3,5,4′-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway
Environmental Toxicology (Wiley) Taiwan, 24 October 2017
Toxicology
Key words: Tetrahydroxystilbene-2-O-β-d-glucoside (THSG), Polygoni Multiflori, adriamycin (AD), quinone oxidoreductase (NQO)-1 [more]
Organism: Mouse
Tissue: Kidney
Initial graft size and not the innate immune response limit survival of engrafted neural stem cells
Journal of Tissue Engineering and Regenerative Medicine (Wiley) Germany, 22 October 2017
Neuroscience
Key words: Transplantation of neural stem cells (NSCs), Luc2 and copGFP, bioluminescence imaging (BLI) [more]
Organism: Mouse
Tissue: Brain
Tumor angiogenesis and bone metastasis - Correlation in invasive breast carcinoma
Journal of Immunological Methods (Elsevier) USA, 21 October 2017
Oncology
Key words: Breast carcinoma, bone metastasis, tumor angiogenesis, pathological biomarkers [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
The non-canonical ubiquitin activating enzyme UBA6 suppresses epithelial-mesenchymal transition of mammary epithelial cells
Oncotarget (Impact Journals) USA, 20 October 2017
Oncology
Key words: ubiquitination, breast cancer, EMT, Rho GTPase, cell cycle [more]
Organism: Human
Cell Line: MCF-10A cells
TDP-43 proteolysis is associated with astrocyte reactivity after traumatic brain injury in rodents
Journal of Neuroimmunology (Elsevier) Taiwan, 20 October 2017
Neuroscience
Key words: Astrocyte, astrogliosis, traumatic brain injury, transactivation response DNA-binding protein 43 [more]
Organism: Rat
Tissue: Brain
Pathological State: Traumatic Brain Injury
Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease
The Journal of Clinical Investigation (American Society for Clinical Investigation) The Netherlands, 19 October 2017
Nephrology
Key words: Aging, Nephrology, Chronic kidney disease, RNA processing [more]
Organism: Human
Pathological State: Kidney Disease
Cell Line: HK-2 cells
Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression
PLoS One (PLOS) South Korea, 18 October 2017
Oncology
Key words: Cellular FLICE inhibitory protein (c-FLIP), NF-κB, apoptosis, cordycepin [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
Nature Communications (Nature) Austria, Australia, 18 October 2017
Immunology
Key words: Tet-On/Off system, BCL2 overexpression, CRISPR/Cas9, RNA interference (RNAi) [more]
Organism: Mouse
Tissue: Spleen
Lactobacillus gasseri attenuates allergic airway inflammation through PPARγ activation in dendritic cells
Journal of Molecular Medicine (Springer) Taiwan, 14 October 2017
Allergy Research
Key words: Allergy asthma, lactic acid bacillus, peroxisome proliferator-activated receptor gamma (PPARγ), dendritic cells [more]
Organism: Mouse
Tissue: Lung
Pathological State: Asthma
GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis
Journal of Neuroscience (SFN) The Netherlands, 11 October 2017
Neuroscience
Key words: Fibronectin, ganglioside, multiple sclerosis, oligodendrocyte, remyelination [more]
Organism: Mouse
Tissue: Brain
Actein induces apoptosis in leukemia cells through suppressing RhoA/ROCK1 signaling pathway
International Journal of Oncology (Spandidos Publications) China, 10 October 2017
Oncology
Key words: Actein, apoptosis, leukemia, RhoA/ROCK1 signaling pathway [more]
Organism: Mouse
Pathological State: Cancer
Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection
The Journal of Immunology (American Association of Immunologists) Taiwan, 10 October 2017
Immunology
Key words: Dengue virus (DENV), dengue fever, DENV nonstructural protein 1 (NS1) [more]
Organism: Mouse
Tissue: Skin
Pathological State: Dengue Virus Infection
Linarin sensitizes tumor necrosis factor-related apoptosis (TRAIL)-induced ligand-triggered apoptosis in human glioma cells and in xenograft nude mice
Biomedicine & Pharmacotherapy (Elsevier) China, 06 October 2017
Oncology
Key words: TRAIL, glioma, linarin (LIN), apoptosis, ROS generation [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs
Cancer Research (AACR Publications) USA, 25 September 2017
Oncology
Key words: Oral tongue squamous cell carcinoma (OTSCC), PD-1, tumor microenvironment (TME), tumor-infiltrating lymphocytes (TIL) [more]
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
The microRNA ame-miR-279a regulates sucrose responsiveness of forager honey bees (Apis mellifera)
Insect Biochemistry and Molecular Biology (Elsevier) USA, China, 20 September 2017
Zoology
Key words: microRNA, honey bee, proboscis extension reflex, sucrose responsiveness, division of labour [more]
Organism: Honey Bee
Tissue: Brain
Axonal components of nerves innervating the human arm
Annals of Neurology (Wiley) Austria, 20 September 2017
Neuroscience
Key words: Nerves, sensory and motir axons, spinal cord, neurofilament [more]
Organism: Human
Tissue: Nerves
Role of BDNF and neurotrophic receptors in human inner ear development
Cell and Tissue Research (Springer) Austria, Seweden, 19 September 2017
Developmental Biology
Key words: Inner ear, Human, BDNF, Neurotrophin receptors, In situ hybridization [more]
Organism: Human
Tissue: Bone
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
Nature Communications (Nature) USA, Austria, 19 September 2017
Oncology
Key words: Melanoma, oncogenic BRAFV600E, growth factor FGF-2, [more]
Organism: Human
Tissue: Skin, Lymphoid Tissue
Pathological State: Cancer
Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials
Oncotarget (Impact Journals) Austria, 15 September 2017
Oncology
Key words: epidermal growth factor receptor, radio-immunotherapy, canine mammary carcinoma, canine antibody, comparative oncology [more]
Organism: Dog
Tissue: Breast
Pathological State: Cancer
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation
Oncogene (Nature) Taiwan, 11 September 2017
Oncology
Key words: Glycosylation, CEACAM6, OSCC (oral squamous cell carcinoma), EGFR [more]
Organism: Human
Pathological State: Cancer
Cell Line: OC-2 and OEC-M1 cells
The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice
Scientific Reports (Nature) The Netherlands, 11 September 2017
Nephrology
Key words: Type 2 diabetes mellitus (T2DM), diabetic nephropathy, Sul-121, glomerular fibronectin expression [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Diabetes
A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines
Neuropharmacology (Elsevier) Czech Republic, 09 September 2017
Neuroscience
Key words: EGCG, green tea, spinal cord injury, neuroregeneration, cytokines, neuroprotection, p65NFkB [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
579 High-risk human papillomavirus infection in Bowen’s disease and Squamous Cell Carcinomas of the hands
Journal of Investigative Dermatology (Elsevier) Austria, 08 September 2017
Dermatology
Key words: Papillomavirus infection, Bowen’s disease, squamous cell carcinomas [more]
Organism: Human
Tissue: Skin
Pathological State: Bowen's Disease, Cancer
Exploring Metabolic Configurations of Single Cells within Complex Tissue Microenvironments
Cell Metabolism (Elsevier) Austria, 07 September 2017
Cell Biology
Key words: Metabolic configuration, single cell, intracellular metabolism, intercellular metabolism, enzyme histochemistry, microenvironment, immunometabolism, cancer metabolism, metabolic biomarke, metabolic imaging method [more]
Organism: Mouse, Human
Tissue: Liver, Muscle, Colon, Breast
Pathological State: Cancer
4103Validation of cardiac magnetic resonance T1 mapping in cardiac amyloidosis
European Heart Journal (Oxford University Press) Austria, 29 August 2017
Cardiology
Key words: cardiac amyloidosis, cardiac mri [more]
Organism: Human
Tissue: Heart
Pathological State: Cardiac Amyloidosis
Placental Dysfunction Underlies Increased Risk of Fetal Growth Restriction and Stillbirth in Advanced Maternal Age Women
Scientific Reports (Nature) UK, 29 August 2017
Reproductive Medicine
Key words: Ageing, disease model, intrauterine growth, reproductive disorders [more]
Organism: Human
Tissue: Placenta
Selective targeting of a novel vasodilator to the uterine vasculature to treat impaired uteroplacental perfusion in pregnancy
Theranostics (NCBI) UK, USA, Estonia, Italy, 29 August 2017
Reproductive Medicine
Key words: pregnancy, placenta, nitric oxide, endothelium, vascular biology, drug targeting [more]
Organism: Mouse
Tissue: Placenta
Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment
Neuro-Oncology (Oxford University Press) USA, Germany, 26 August 2017
Oncology
Key words: glioblastoma, microglia, macrophage, osteopontin, SPP1, glioblastoma cd45 antigens macrophage-1 antigen macrophages microglia monocytes brain mice neoplasms osteopontin [more]
Organism: Human
Pathological State: Cancer
Cell Line: Ki67 cells
Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression
GLIA (Wiley) Germany, 24 August 2017
Neuroscience
Key words: Brain-intrinsic degenerative cascades, multiple sclerosis, Cup/EAE model [more]
Organism: Mouse
Tissue: Brain
Pathological State: Encephalomyelitis
Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells
Cancer Immunology Research (AACR Publications) Taiwan, 23 August 2017
Oncology
Key words: Tumor suppressor gelsolin (GSN), gastric cancer, DNA methylation [more]
Organism: Human
Tissue: Endometrium
Pathological State: Cancer
Zika virus infects renal proximal tubular epithelial cells with prolonged persistency and cytopathic effects
Emerging Microbes & Infections (Nature) China, 23 August 2017
Immunology, Virology
Key words: Cytopathic effects, prolonged persistency, renal proximal tubular epithelial cells, urinary system, Zika virus [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Zika Virus Infection, Guillain–Barré syndrome
Efficient cell death induction in human glioblastoma cells by photodynamic treatment with Tetrahydroporphyrin-Tetratosylat (THPTS) and ionizing irradiation
Oncotarget (Impact Journals) Germany, Belarus, 23 August 2017
Oncology
Key words: photodynamic therapy, glioblastoma, THPTS, combination, ionizing radiation [more]
Organism: Human
Cell Line: Human authenticated GBM cell lines (A-172, U-87 MG, and DBTRG-05MG)
Reactive oxygen species–mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression
Scientific Reports (Nature) Taiwan, 22 August 2017
Oncology
Key words: Stromelysin 1 (MMP-3) and 2 (MMP-10), prostate cancer-associated stromal fibroblasts (CAFs), extracellular matrix (ECM) [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
Screening platform for cell contact guidance based on inorganic biomaterial micro/nanotopographical gradients
Applied Materials and Interfaces (ACS Publications) The Netherlands, 21 August 2017
Stem Cell Research
Key words: Biomimetic surface, high-throughput screening, inorganic biomaterials, stem cell behavior, topographical gradient [more]
Organism: Human
Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)
Bifidobacterium Infantis Ameliorates Chemotherapy-Induced Intestinal Mucositis Via Regulating T Cell Immunity in Colorectal Cancer Rats
Cellular Physiology and Biochemistry (Karger) China, 18 August 2017
Oncology
Key words: Bifidobacterium infantis, intestinal mucositis, 5-fluorouracil, oxaliplatin, CD4+CD25+Foxp3+ Tregs, CD4+CD17A+ cells, colorectal cancer [more]
Organism: Rat
Tissue: Allograft Tumor
Pathological State: Cancer
An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis
Cell Reports (Cell Press) USA, 15 August 2017
Oncology
Key words: ARACNe, MARINa, VIPER, breast, cancer, metastasis, transcription, TRIM25, EFP [more]
Organism: Mouse
Tissue: Allograft Tumor, Lung
Pathological State: Cancer
Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of Pseudomonas aeruginosa Infection
Antimicrobial Agents and Chemotherapy (American Society for Microbiology) USA, 14 August 2017
Microbiology
Key words: Pseudomonas aeruginosa, abscesses, neutrophils, phenoxyacetamide inhibitors, type III secretion [more]
Organism: Mouse
Tissue: Liver, Spleen
Pathological State: Abscess
Effects of sulfur mustard on mesenchymal stem cells
Toxicology Letters (Elsevier) Germany, 14 August 2017
Toxicology
Key words: Sulfur mustard, mesenchymal stem cells, senescence, apoptosis, proliferation [more]
Organism: Human
Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)
Attenuation of Follicular Helper T Cell–Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjögren's Syndrome
Arthritis & Rheumatology (Wiley) The Netherlands, 13 August 2017
Rheumatology
Key words: CTLA-4Ig, CD4+ T cell, Sjögren's syndrome, marker ICOS [more]
Organism: Human
Pathological State: Sjögren's Syndrome
Role of glial-cell-derived neurotrophic factor in salivary gland stem cell response to irradiation
Radiotherapy and Oncology (Elsevier) The Netherlands, 04 August 2017
Oncology
Key words: Salivary glands, GDNF, stem cells, spheres, radiation-induced xerostomia [more]
Organism: Human
Tissue: Salivary Gland
Traditional Chinese medicine Danggui Buxue Tang inhibits colorectal cancer growth through induction of autophagic cell death
Oncotarget (Impact Journals) Taiwan, 03 August 2017
Oncology
Key words: Danggui Buxue Tang, colorectal cancer, autophagy, traditional Chinese medicine, mammalian target of rapamycin (mTOR) [more]
Organism: Mouse
Tissue: Colon, Xenograft Tumor
Pathological State: Cancer
The Prognostic Role of T1 Mapping Sequences: Can T1 Mapping Parameters Have a Role in Risk Stratification?
Cardiovascular Imaging Asia (Kamje Press) South Korea, 31 July 2017
Cardiology
Key words: Cardiac magnetic resonance imaging, T1 mapping, Prognosis [more]
Organism: Human
Tissue: Heart
Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas
Oncogene (Nature) USA, Switzerland, 31 July 2017
Oncology
Key words: Glioblastomas, tumor microenvironment (TME)-mediated extrinsic resistance, PDGF-B-driven proneural glioma mouse model [more]
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
Parathyroid hormone regulates fates of murine osteoblast precursors in vivo
The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 31 July 2017
Stem Cell Research
Key words: Parathyroid hormone, osteoblast precursors, bone biology, stem cells [more]
Organism: Mouse
Tissue: Bone
Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling
Cancer Research (AACR Publications) South Korea, 28 July 2017
Oncology
Key words: Necrosis, glioblastoma, transglutaminase 2 (TGM2), transcription factors (TF) [more]
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis
PLoS One (PLOS) Austria, 24 July 2017
Immunology
Key words: Cell metabolism, mammalian target of rapamycin (mTOR), interleukin (IL)-12 and anti-inflammatory IL-10 [more]
Organism: Mouse
Tissue: Liver, Spleen
CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer
OncoImmunology (Taylor and Francis) The Netherlands, 24 July 2017
Oncology
Key words: CD103, cervical cancer, intraepithelial T cells, therapeutic vaccination, tumor-infiltrating lymphocytes [more]
Organism: Human
Tissue: Uterus
Pathological State: Cancer
Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning
Toxicology (Elsevier) Germany, 22 July 2017
Toxicology
Key words: Chemical warfare agents, nerve agents, pesticide, lung, PCLS, precision cut lung slices [more]
Organism: Rat
Tissue: Lung
Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications
Translational Research (Elsevier) USA, 22 July 2017
Medical Imaging
Key words: 2D2 dimensional, 3D3 dimensional, LSM- light sheet microscopy, IHCS- imaging high content screening, VTEA -Volumetric tissue exploration and analysis, 3DTC-3 dimensional tissue cytometry
Neuron-Specific Fluorescence Reporter-Based Live Cell Tracing for Transdifferentiation of Mesenchymal Stem Cells into Neurons by Chemical Compound
Stem Cells International (Hindawi Publishing Corporation) South Korea, 20 July 2017
Stem Cell Research
Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration
Advanced Drug Delivery Reviews (Elsevier) USA, 19 July 2017
Regenerative Medicine
Key words: Stem cell homing, growth factor delivery, chemoattractant gradients, endothelialization, extracellular matrix, bone graft substitutes, myocardial regeneration [more]
Organism: Human
Cell Line: Human mesenchymal stem cells (hMSCs)
The c.1085A>G genetic variant of CSF1R gene regulates tumor immunity by altering the proliferation, polarization, and function of macrophages
Clinical Cancer Research (AACR Publications) Taiwan, 19 July 2017
Oncology
Key words: Tumor, CSF1R, low VEGF expression, altering the polarization and function of macrophages [more]
Organism: Human
Tissue: Colon, Ovaries, Endometrium
Pathological State: Cancer
Production of reactive persulfide species in chronic obstructive pulmonary disease
Thorax (BMJ Journals) Japan, 19 July 2017
Pulmonology
Key words: Oxidative Stress [more]
Organism: Human
Tissue: Lung
Pathological State: Chronic Obstructive Pulmonary Disease
MicroRNA 155-deficiency leads to decreased autoantibody levels and reduced severity of nephritis and pneumonitis in pristaneinduced lupus
PLoS One (PLOS) Austria, 18 July 2017
Immunology
Key words: Systemic lupus, miR155-deficient, PBS-injected mice, glomerulonephritis, pneumonitis [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Lupus
Analysis of cysteine-X-cysteine motif chemokine ligands 9, 10, and 11, their receptor CXCR3, and their possible role on the recruitment of immune cells at the maternal–conceptus interface in pigs†
Biology of Reproduction (Oxford University Press) South Korea, 15 July 2017
Immunology
Key words: Pig, pregnancy, uterus, endometrium, CXCL9, CXCL10, CXCL11 [more]
Organism: Human
Tissue: Endometrium
Pathological State: Cancer
Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1
British Journal of Haematology (Wiley) Austria, 14 July 2017
Oncology
Key words: The p21-activated kinases (PAKs), BCR/ABL1+ haematopoietic malignancy, leukaemic cells [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Placental homing peptide-microRNA inhibitor conjugates for targeted enhancement of intrinsic placental growth signaling
Theranostics (NCBI) UK, 14 July 2017
Reproductive Medicine
Key words: fetal growth restriction, IGF-II, microRNA, placenta, proliferation, pregnancy [more]
Organism: Human
Tissue: Placenta
RIP3 attenuates the pancreatic damage induced by deletion of ATG7
Cell Death & Disease (Nature) Germany, 13 July 2017
Gastroenterology
Key words: Pancreatitis, Rip3, acinar cells, autophagy and necroptosis [more]
Organism: Human, Mouse
Tissue: Pancreas
Small cell lung cancer: model of circulating tumor cell tumorospheres in chemoresistance
Scientific Reports (Nature) Austria, 13 July 2017
Oncology
Key words: Small cell lung cancer (SCLC), circulating tumor cells (CTCs), Ki67 and carbonic anhydrase 9 (CAIX) [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Tailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson's disease
Biomaterials (Elsevier) Taiwan, 12 July 2017
Biological Materials
Key words: Platelet lysate, neuroprotection, parkinson, MPTP, neurotrophins, growth factors [more]
Organism: Mouse
Tissue: Brain
CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions
Cardiovascular Research (Oxford University Press) Taiwan, 11 July 2017
Cardiology
Key words: CEBPD, inflammation, macrophages, PTX3, statins [more]
Organism: Mouse
Pathological State: Vascular lesions
Cell Line: Macrophages and nile red-positive cells
Instructing cells with programmable peptide DNA hybrids
Nature Communications (Nature) USA, 10 July 2017
Cell Biology
Key words: Native extracellular matrix, peptide-DNA (P-DNA) [more]
Organism: Mouse
Cell Line: NIH-3T3 mouse embryonic fibroblasts
Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis
Oncotarget (Impact Journals) Italy, 07 July 2017
Oncology
Key words: cerebellum, expression profiles, medulloblastoma, apoptosis, senescence [more]
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
A novel in vitro model of villitis of unknown etiology demonstrates altered placental hormone and cytokine profile
American Journal of Reproductive Immunology (Wiley) UK, 06 July 2017
Reproductive Medicine
Key words: Placental dysfunction, villitis of unknown etiology, T cell, fetal growth restriction [more]
Organism: Human
Cell Line: Placental explant culture
Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion
Stem Cells (Wiley) Czech Republic, 06 July 2017
Stem Cell Research
Key words: Human pluripotent stem cells (hPSCs), fibroblast growth factor (FGF) receptors, hepatocellular carcinoma (TEC) [more]
Organism: Human
Cell Line: hPSCs (Human pluripotent stem cells)
Increased migration of antigen presenting cells to newly-formed lymphatic vessels in transplanted kidneys by glycol-split heparin
PLoS One (PLOS) The Netherlands, 30 June 2017
Transplantation Medicine
Key words: Chronic renal transplant, lymphatic chemokine-proteoglycan, renal graft [more]
Organism: Rat
Tissue: Kidney
Pathological State: Chronic Transplant Dysfunction, Organ Transplantation
Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation
Journal of Experimental Medicine (Rockefeller University Press) USA, 29 June 2017
Neuroscience
Key words: Herpes simplex virus (HSV), keratinocytes, IL-17c, nervous system [more]
Organism: Human
Tissue: Skin
Cell Line: Keratinocytes
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
Nature Communications (Nature) South Korea, 28 June 2017
Oncology
Key words: Colon cancer, mechanisms of disease [more]
Organism: Mouse
Tissue: Small Intestine
Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells
Oncotarget (Impact Journals) Taiwan, 27 June 2017
Oncology
Key words: hinokitiol, miR-494-3p, BMI1, breast cancer, cancer stem cells [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis
Cell Death Discovery (Nature) Germany, 19 June 2017
Gastroenterology
Key words: Apoptosis, chronic pancreatitis, macroautophagy, necroptosis [more]
Organism: Human, Mouse
Tissue: Pancreas
Pathological State: Pancreatitis
Breviscapine (BVP) inhibits prostate cancer progression through damaging DNA by minichromosome maintenance protein-7 (MCM-7) modulation
Biomedicine & Pharmacotherapy (Elsevier) China, 17 June 2017
Oncology
Key words: Breviscapine, human prostate cancer, DNA damage, MCM-7, Apoptosis [more]
Organism: Human, Mouse
Tissue: Prostate, Xenograft Tumor
Pathological State: Cancer
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation
Molecular Cancer Therapeutics (AACR Publications) Czech Republic, 15 June 2017
Oncology
Key words: Tumor cells, serine threonine kinase, DNA antimetabolites [more]
Organism: Human, Mouse
Tissue: Skin, Xenograft Tumor
Pathological State: Cancer
Inhibition of the NOD-like receptor protein 3 inflammasome is protective in juvenile influenza A virus infection
Frontiers in Immunology (Frontiers Media S.A.) USA, 10 June 2017
Immunology
Key words: Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection [more]
Organism: Mouse
Tissue: Lung
Pathological State: Influenza Infection
Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer
Oncology Letters (Spandidos Publications) Austria, Belgium, Germany, 03 June 2017
Oncology
Key words: pithelial ovarian cancer, estrogen, estrogen metabolizing enzymes, STS, sulfotransferase, SULT1E1, E2, ovarian cancer [more]
Organism: Human
Tissue: Ovaries
Pathological State: Cancer
Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy
Endocrinology (Oxford University Press) UK, 02 June 2017
Endocrinology
Key words: Calcium-Sensing Receptor, CaSR, Hyperglycemia, Calcilytic Therapy, glucose homeostasis, Diabetes [more]
Organism: Mouse
Tissue: Xenograft Tumor, Pancreas
Pathological State: Cancer
Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice
Scientific Reports (Nature) Taiwan, 02 June 2017
Immunology, Virology
Key words: Age-related autoimmune hepatitis, cell senescence, apoptosis, concanavalin A (Con A), [more]
Organism: Mouse
Tissue: Liver
Extracellular matrix hydrogel derived from human umbilical cord as a scaffold for neural tissue repair and its comparison with extracellular matrix from porcine tissues
Tissue Engineering Part C (Mary Ann Liebert Inc.) Czech Republic, 01 June 2017
Regenerative Medicine
Key words: Hydrogel, Umbilical Cord, Neural Tissue Repair, Extracellular Matrix, Porcine Tissues [more]
Organism: Rat
Tissue: Spinal Cord
Cell Line: Dorsal root ganglia
Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
Cell Reports (Cell Press) USA, 30 May 2017
Oncology
Key words: wild-type IDH1, GBM, metabolism, differentiation, NADPH, lipids, reactive oxygen species (ROS), EGFR, targeted therapy [more]
Organism: Mouse
Pathological State: Cancer
Cell Line: GIC-20 (Glioma initiating cells)
Automated Image Analysis of HER2 Fluorescence In Situ Hybridization to Refine Definitions of Genetic Heterogeneity in Breast Cancer Tissue
BioMed Research International (Hindawi Publishing Corporation) Lithuania, Austria, 28 May 2017
Medical Image Analysis
Key words: Automated Image Analysis, HER2 FISH, Genetic Heterogeneity, Breast Cancer [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling
Toxicology and Applied Pharmacology (Elsevier) China, 27 May 2017
Oncology
Key words: Cisplatin nephrotoxicity, ERK, Galangin, Inflammation, NF-κB, Oxidative stress [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Acute Kidney Injury
Hepatic IFIT3 predicts interferon-α therapeutic response in patients of hepatocellular carcinoma
Hepatology (Wiley) China, 26 May 2017
Oncology
Key words: Adjuvant interferon-α (IFN-α), hepatocellular carcinoma (HCC), IFIT3, [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
QUICK FIRE CASES- SESSION III
European Heart Journal (Oxford University Press) Denmark, 25 May 2017
Cardiology
Key words: Myocardium, diagnosis, fire - disaster, s fire - physical, phenomenon cardiac, mri [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor
Cancer Research (AACR Publications) USA, 23 May 2017
Oncology
Key words: Isocitrate dehydrogenase IDH2, α-ketoglutarate, cancer cells, SIRT3 [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Single allele Lmbrd1 knockout results in cardiac hypertrophy
Journal of the Formosan Medical Association (Elsevier) Taiwan, 23 May 2017
Cardiology
Key words: Cardiac hypertrophy, Disease animal model, Gene knockout, Mouse Lmbrd1 gene, Human LMBRD1 gene, LMBD1 protein [more]
Organism: Mouse
Tissue: Heart
Pathological State: Cardiac Hypertrophy
MicroRNA-146a governs fibroblast activation and joint pathology in arthritis
Journal of Autoimmunity (Elsevier) Austria, 22 May 2017
Rheumatology
Key words: Synovial fibroblasts, miR-146a, tumor necrosis factor (TNF) receptor, factor 6 (TRAF6), osteoprotegerin (OPG) [more]
Organism: Human
Tissue: Bone
Pathological State: Rheumatoid Arthritis
Significance of B10 cell in patients with thymoma complicated with myasthenia gravis
Oncotarget (Impact Journals) China, 17 May 2017
Oncology
Key words: regulatory B cell, B10 cell, thymoma, myasthenia gravis, autoimmune abnormality [more]
Organism: Human
Tissue: Thymus
Pathological State: Cancer
Enhanced Bruton's Tyrosine Kinase Activity in Peripheral Blood B Lymphocytes From Patients With Autoimmune Disease
Arthritis & Rheumatology (Wiley) The Netherlands, 10 May 2017
Rheumatology
Key words: Bruton's tyrosine kinase (BTK), B cell receptor (BCR), Sjögren's syndrome (SS), BTK phosphorylation [more]
Organism: Human
Tissue: Salivary Gland
Pathological State: Sjögren's Syndrome
Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time
Aging Cell (Wiley) Taiwan, 04 May 2017
Stem Cell Research
Key words: Hyaluronan (HA), mesenchymal stem cells (MSCs), cellular aging, human placenta-derived MSCs (PDMSC) [more]
Organism: Human
Cell Line: Human mesenchymal stem cells (hMSCs)
CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice
The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 02 May 2017
Immunology
Key words: Autoimmunity, Immunology [more]
Organism: Mouse
Tissue: Heart, Skin
A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer
Cancer Letters (Elsevier) Taiwan, 24 April 2017
Oncology
Key words: DNA damage, DNA repair, Ubiquitin–proteasome system, Triple-negative breast cancer [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Cytotoxicity of Natural Killer Cells Activated Through NKG2D Contributes to the Development of Bronchiolitis Obliterans in a Murine Heterotopic Tracheal Transplant Model
American Journal of Transplantation (Wiley) Japan, 21 April 2017
Transplantation Medicine
Key words: Basic (laboratory) research/science, lung transplantation/pulmonology, bronchiolitis obliterans (BOS), natural killer (NK) cells/NK receptors [more]
Organism: Mouse
Tissue: Lung
Pathological State: Organ Transplantation
Two different, mutually exclusively distributed, TP53 mutations in ovarian and peritoneal tumor tissues of a serous ovarian cancer patient: indicative for tumor origin?
Molecular Case Studies (CSH Press) Austria, 14 April 2017
Oncology
Key words: Mutually exclusive p53 mutations in ovarian cancer [more]
Organism: Human
Tissue: Ovaries
Pathological State: Cancer
Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells
Applied Materials and Interfaces (ACS Publications) USA, 13 April 2017
Oncology
Key words: And image-guided therapy, cancer immunotherapy interferon-gamma (IFN-γ), microspheres, natural killer (NK) cells infiltration [more]
Organism: Human
Extravillous Trophoblast and Endothelial Cell Crosstalk Mediates Leukocyte Infiltration to the Early Remodeling Decidual Spiral Arteriole Wall
The Journal of Immunology (American Association of Immunologists) UK, Canada, 10 April 2017
Immunology
Key words: Decidual spiral arteriole (SpA), uterine decidual NK (dNK) cells, extravillous trophoblasts (EVTs), chemokines [more]
Organism: Human
Tissue: Endometrium
EGFR in Tumor-associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients
Gastroenterology (Elsevier) Austria, 09 April 2017
Oncology
Key words: Tumor microenvironment, cytokine, CRC, colon cancer [more]
Organism: Human, Mouse
Tissue: Colon
Pathological State: Cancer
Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)
Gastric Cancer (Springer) Japan, 07 April 2017
Oncology
Key words: Cancer stem cell, CD44 variant positive, Gastric cancer, Sulfasalazine xCT [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
Surviving murine experimental sepsis affects the function and morphology of the inner ear
Biology Open (The Company of Biologists) Austria, 04 April 2017
Physiology
Key words: Sepsis, Hearing loss, Inner ear, Inflammation, Apoptosis [more]
Organism: Mouse
Pathological State: Sepsis
Intracerebral delivery of the M2 polarizing cytokine interleukin 13 using mesenchymal stem cell implants in a model of temporal lobe epilepsy in mice
Official Journal of the International League Against Epilsepy (Wiley) Belgium, 04 April 2017
Transplantation Medicine
Key words: IL-13 MSCs, acid–induced status epilepticus, video–electroencephalography, F4/80+ cells [more]
Organism: Mouse
Tissue: Brain
Pathological State: Epilepsy
Information Limits of Optical Microscopy: Application to Fluorescent Labelled Tissue Section
Bioinformatics and Biomedical Engineering (Springer) Austria, Czech Republic, 01 April 2017
Microscopy
Key words: Electromagnetic centroid, Point divergence gain, Superresolution, 3D structure reconstruction [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
High expression of CASZ1 is associated with poor prognosis in ovarian cancer
Cancer Research (AACR Publications) Taiwan, 01 April 2017
Oncology
Key words: High expression of CASZ1 is associated with poor prognosis in ovarian cancer [more]
Organism: Human
Tissue: Ovaries
Pathological State: Cancer
Brilliant Blue G, but not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease
Cell Transplantation (SAGE Journals) Brazil, 01 April 2017
Neuroscience
Key words: Parkinson's disease (PD), P2X7 receptor, brilliant Blue G (BBG), PGC-1α, fenofibrate [more]
Organism: Rat
Tissue: Brain
ICAM-1 binding rhinoviruses enter HeLa cells via multiple pathways and travel to distinct intracellular compartments for uncoating
Viruses (MDPI) Austria, 01 April 2017
Virology
Key words: human rhinoviruses, ICAM-1, productive uncoating, endocytosis, clathrin, dynamin, macropinocytosis, actin, dynein [more]
Organism: Human
Pathological State: Virus Infection
Cell Line: HeLA cells
Colibactin contributes to the hypervirulence of pks+ K1 CC23 Klebsiella pneumoniae in mouse meningitis infections
Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) Taiwan, 31 March 2017
Microbiology
Key words: Colibactin, pks+ K1 CC23 Klebsiella pneumoniae, Mouse Meningitis [more]
Organism: Mouse
Tissue: Small Intestine, Colon, Liver, Spleen, Brain
Pathological State: Klebsiella Infection, Meningitis
Early, but not late treatment with human umbilical cord blood-derived mesenchymal stem cells attenuates cisplatin nephrotoxicity through immunomodulation
American Journal of Physiology (APS Journals) South Korea, 29 March 2017
Physiology
Key words: Acute kidney injury, Cisplatin nephrotoxicity, immunomodulation, mesenchymal stem cells, regulatory T cells [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Acute Kidney Injury
HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice
Scientific Reports (Nature) The Netherlands, 27 March 2017
Immunology
Key words: Mechanism of action, Pharmacodynamics [more]
Organism: Mouse
Tissue: Lung
Pathological State: Inflammation