P2X7 receptor

FEATURED PUBLICATION

P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma
Frontiers in Oncology

Arnaud-Sampaio et al. addressed the persistent problem of drug resistance in cancer and elucidated the role of the P2X7 receptor in chemoresistance, using TissueFAXS platform for image acquisition and StrataQuest software for in-depth cytometric quantifications. The paper was published in Frontiers in Oncology.

Cytotoxic CD8+ T cells may be drivers

FEATURED PUBLICATION

Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome
scientific reports

In this study, published in scientific reports Nature, Kaneko et al. investigated the role of CD4+ and CD8+ T cell subsets in salivary glands of patients with Sjögren’s syndrome. In order to perform an in-depth quantitative analysis, the power of TissueFAXS platform, and both TissueQuest and StrataQuest software were utilized.

Adverse Effects of Single

FEATURED PUBLICATION

A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells
cancers

This study from Liang et al. (University of Gothenburg) assessed phenotypic and functional characteristics of tumor infiltrating lymphocytes within colorectal liver metastases (CRLM). For the in-situ tissue cytometry analysis, with the main focus on CD103+CD8+ TRM cells, the power of TissueFAXS CHROMA and StrataQuest was utilized.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

The role of S100A9

FEATURED PUBLICATION

The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells
Cancer Immunology, Immunotherapy

Kung et al. recently published a study, in the journal Cancer, evaluating the prognostic role of S100A9 (acting as chemoattractant for circulatory monocytes) in pancreatic ductal adenocarcinoma as well as its influence on PD-L1 expression. TissueFAXS PLUS and StrataQuest were used to assess co-expression of PD-L1 and S100A9 in human PDAC tissues.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Differential localization

FEATURED PUBLICATION

Differential localization and limited cytotoxic potential of duodenal CD8+ T cells
The Journal of Clinical Investigation

In a recent study published in The Journal of Clinical Investigation, Mvaya et al. were able to demonstrate the limited potential of duodenal CD8+ T cells in tissue samples from people living with HIV. High content immunophenotyping within duodenal tissue sections was performed using TissueFAXS i PLUS and the single cell analysis software TissueQuest.

Azvudine

FEATURED PUBLICATION

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients
Signal Transduction and Targeted Therapy

Zhang et al, published a study in the journal Signal Transduction Targeted Therapy, with the main focus on the investigation of the effect of Azvudine, in SARS-CoV-2 infected rhesus macaques as well as in COVID-19 patients. The group used TissueFAXS Q as well as TissueQuest to quantify the viral load, immune-status and TUNEL staining within thymus tissues.

Functional Impairment

FEATURED PUBLICATION

Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia
Immunity

In a recent study published in the journal Immunity, Collins et al (Ragon Institute of MGH, MIT and Harvard) were able to show key immunologic and virologic parameters of durable HIV control. For high resolution visualization of the virus, lymph node tissues were marked with HIV specific RNAScope probes and acquired using TissueFAXS Q.

AC-265347 Inhibits

FEATURED PUBLICATION

AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia
International Journal of Molecular Sciences

This recently published study was conducted within the CaSR Biomedicine Training network. Gonçalves-Alves et al. were able to demonstrate the inhibitory effect of the drug AC-265347 on neuroblastoma tumor growth. Expression of various markers (Ki67, CaSR, CD44, TrkA, NF68) was assessed by using TissueFAXS PLUS and StrataQuest.

Filter publications

Customer Publications (A total of 2213 papers published)

1801
Diverse T-cell responses characterize the different manifestations of cutaneous graft-versus-host disease

Marie-Charlotte Brüggen, Irene Klein, Hildegard Greinix, Wolfgang Bauer, Zoya Kuzmina, Werner Rabitsch, Peter Kalhs, Peter Petzelbauer, Robert Knobler, Georg Stingl, Georg Stary

Blood (American Society of Hematology) Austria, 09 January 2014

Transplantation Medicine

Key words: Distinct T-cell patterns characterize the acute and chronic forms of cutaneous GVHD, increased TSLP expression is an indicator of acute cutaneous GVHD development.

Organism: Human

Tissue: Skin

Pathological State: Graft-versus-host disease

1802
Macrophage Quantification in Different Breast Tumor Compartments.

Haisan, Anca, Petreus, T, Jitaru, Daniela, Danciu, M, Carasevici, E

Jurnalul de Chirurgie (search.ebscohost.com) Romania, 01 January 2014

Oncology

1803
Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats

Terézia Kisková, Rastislav Jendzelovsky, Erdenetsetsek Rentsen, Alexandra Maier-Salamon, Natalia Kokosova, Zuzana Papcova,Jaromır Mikes, Peter Orendas, Bianka Bojkova, Peter Kubatka, Martin Svoboda, Karol Kajo, Peter Fedorocko, Walter Jager, Cem Ekmekcioglu, Monika Kassayova and Theresia Thalhammer

European Journal of Cancer Prevention (Wolters Kluwer) Austria, 01 January 2014

Oncology

Key words: celecoxib, chemically induced breast cancer, COX2, GDF15, MCF-7 cells, oxidative stress, resveratrol

Organism: Rat

Tissue: Breast

Pathological State: Cancer

1804
Lymph node status assessed through the log odds ratio–a better tool in the prognosis of colorectal cancer relapse

ST Makkai-Popa, S Luncă, E Târcoveanu, E Carasevici, G Dimofte

Romanian Journal of Morphology and Embryology () Romania, 01 January 2014

Oncology

Key words: disease-free interval, lymph node ratio, log odds ratio.

1805
HISTOQUEST–MODALITY OF MICROANATOMICAL ANALYSIS OF THE IMMUNOHISTOCHEMICAL COLORATION IN BREAST CANCER AND DATA …

Vrânceanu, Anca, Tărniceriu, Claudia Cristina, Makkai, S, Carasevici, E

(search.ebscohost.com) Romania, 01 January 2014

Oncology

1806
Role of endocytic uptake in transfection efficiency of solid lipid nanoparticles-based nonviral vectors

Aritz Perez Ruiz de Garibay, María Ángeles Solinís Aspiazu, Alicia Rodríguez Gascón, Haleh Ganjian, Renate Fuchs

Journal of Gene Medicine (Wiley) Spain, Austria, 27 December 2013

Nanomedicine

Key words: Endocytosis, lysosome, nonviral vector, solid lipid nanoparticles, transfection

Organism: Human

Cell Line: HeLa cells

1807
Ginsenoside Rg3 Up-regulates the Expression of Vascular Endothelial Growth Factor in Human Dermal Papilla Cells and Mouse Hair Follicles

Dae Hyun Shin, Youn Jeong Cha, Kyeong Eun Yang, Ik-Soon Jang, Chang-Gue Son, Bo Hyeon Kim, Jung Min Kim

Phytotherapy Research (Wiley) South Korea, 26 December 2013

Dermatology

Key words: Rg3, hair growth, DP cell, gene expression profiles, VEGF, stemness marker

Organism: Human

Cell Line: Dermal Papilla cells

1808
Application of quinidine on rat sciatic nerve decreases the amplitude and increases the latency of evoked responses

Kuang-I Cheng, I-Ling Lin, Lin-Li Chang, I-Ming Jou, Chung-Sheng Lai, Jhi-Joung Wang, Hung-Chen Wang, Aij-Lie Kwan

Journal of Anesthesia (Springer) Taiwan, 15 December 2013

Anesthesiology

Key words: Sciatic nerve, lidocaine, sciatic nerve fiber, contralateral hind limb, rat sciatic nerve, quinidine concentration, sodium channel, ranvier node, myelinated nerve fiber, local anesthetic, nerve conduction, peripheral nerve, neuropathic pain, conduction velocity

Organism: Rat

Tissue: Brain

1809
Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224

Sheng-Hui Lan, Shan-Ying Wu, Roberto Zuchini, Xi-Zhang Lin, Ih-Jen Su, Ting-Fen Tsai, Yen-Ju Lin, Cheng-Tao Wu and Hsiao-Sheng Liu

Hepatology (Wiley) Taiwan, 13 December 2013

Oncology

Key words: microRNA-224, miR‐224 antagonist, autophagosome fraction, autophagy‐related genes, chloroquine, double distilled water, digoxigenin, hepatitis B virus, hepatitis B virus X protein, hepatocellular carcinoma, hepatitis C virus

Organism: Human

Tissue: Liver

Pathological State: Cancer

1810
Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation

Tsung-Ming Chen, Yu-Heng Shih, Joseph T Tseng, Ming-Chih Lai, Chih-Hao Wu, Yi-Han Li, Shaw-Jenq Tsai, H Sunny Sun

Nucleic Acids Research (Oxford University Press) Taiwan, 10 December 2013

Oncology

Key words: Human fibroblast growth factor 9 , hypoxia, colon cancer cells

Organism: Human

Tissue: Colon

Pathological State: Cancer

1811
Localized Hyperthermia with Iron Oxide–Doped Yttrium Microparticles: Steps toward Image-Guided Thermoradiotherapy in Liver Cancer

Andrew C Gordon, Robert J Lewandowski, Riad Salem, Delbert E Day, Reed A Omary, Andrew C Larson

Journal of Vascular and Interventional Radiology (Elsevier) USA, 06 December 2013

Oncology

Key words: Hepatocellular carcinoma, normal hepatic parenchyma, alternating magnetic field

Organism: Rat

Tissue: Liver

Pathological State: Cancer

1812
MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation

Stefania Puttini, Ruthger W van Zwieten, Damien Saugy, Malgorzata Lekka, Florence Hogger, Deborah Ley, Andrzej J Kulik, Nicolas Mermod

BMC Molecular Biology (Springer) Switzerland, Poland, 02 December 2013

Genetics

Key words: Inducible expression, non-viral vectors, MAR elements, erythropoietin, utrophin, gene therapy

Organism: Mouse

Tissue: Muscle

1813
Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial–mesenchymal transition ZEB1/2

Sabine Konradi, Nighat Yasmin1, Denise Haslwanter, Michele Weber, Bernhard Gesslbauer, Michael Sixt, Herbert Strobl

European Journal of Immunology (Wiley) Austria, 02 December 2013

Immunology

Key words: Cell migration, dendritic cells, epithelial-to-mesenchymal transition, langerhans cells, maturation

Organism: Human

Cell Line: Langerhans cells

1814
Targeting SOD1 reduces experimental non–small-cell lung cancer

Andrea Glasauer, Laura A Sena, Lauren P Diebold, Andrew P Mazar, and Navdeep S Chandel

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 02 December 2013

Oncology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

1815
Transdifferentiation of Adipose-Derived Stem Cells into Keratinocyte-Like Cells: Engineering a Stratified Epidermis

Claudia Chavez-Munoz, Khang T Nguyen,Wei Xu, Seok-Jong Hong,Thomas A Mustoe, Robert D Galiano

PLoS One (PLOS) USA, 02 December 2013

Stem Cell Research

Key words: Keratinocytes, cell staining, transdifferentiation, cell differentiation, mesenchymal stem cells, DAPI staining, antibiotics, fibroblasts

Organism: Human

Cell Line: Adipose-Derived Stem Cells

1816
A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog

Astrid Hagelkruys, Sabine Lagger, Julia Krahmer, Alexandra Leopoldi, Matthias Artaker, Oliver Pusch, Jürgen Zezua, Simon Weissmann, Yunli Xie, Christian Schöfer, Michaela Schlederer, Gerald Brosch, Patrick Matthias, Jim Selfridge, Hans Lassmann, Jürgen A Knoblich, Christian Seiser

Development (The Company of Biologists) Austria, Switzerland, UK, 19 November 2013

Neuroscience

Key words: Histone deacetylases, neural cells, histone acetyltransferases, central nervous system

Organism: Mouse

Tissue: Brain

1817
Developmental and oncogenic radiation effects on neural stem cells and their differentiating progeny in mouse cerebellum

Mirella Tanori, Emanuela Pasquali, Simona Leonardi, Arianna Casciati, Paola Giardullo, Ilaria De Stefano, Mariateresa Mancuso, Anna Saran, Simonetta Pazzaglia

Stem Cells (Wiley) Italy, 15 November 2013

Stem Cell Research

Key words: Ptc1+/- mice, apoptosis, DNA repair, p21, medulloblastoma, carcinogenesis, neural stem cells, progenitor cells

Organism: Mouse

Tissue: Brain

1818
Epidermal Growth Factor Receptor Targeted Nuclear Delivery and High-Resolution Whole Cell X-ray Imaging of Fe3O4@TiO2 Nanoparticles in Cancer Cells

Ye Yuan, Si Chen, Tatjana Paunesku, Sophie Charlotte Gleber, William C Liu, Caroline B Doty, Rachel Mak, Junjing Deng, Qiaoling Jin, Barry Lai, Keith Brister, Claus Flachenecker, Chris Jacobsen, Stefan Vogt, Gayle E Woloschak

ACS NANO (ACS Publications) USA, 12 November 2013

Medical Imaging

Key words: Nanoparticles, titanium dioxide, photoactivation, X-ray fluorescence microscopy, epidermal growth factor receptor

Organism: Human

Cell Line: HeLa cells

1819
Cardiac magnetic resonance postcontrast T1 time is associated with outcome in patients with heart failure and preserved ejection fraction

Mascherbauer J, Marzluf BA, Tufaro C, Pfaffenberger S, Graf A, Wexberg P, Panzenböck A, Jakowitsch J, Bangert C, Laimer D, Schreiber C, Karakus G, Hülsmann M, Pacher R, Lang IM, Maurer G, Bonderman D

Circulation:Cardiovascular Imaging (AHA Journals) Austria, Turkey, 06 November 2013

Cardiology

Key words: Hypertension, pulmonary, magnetic resonance imaging, prognosis

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

1820
Alcohol Exacerbates LPS-Induced Fibrosis in Subclinical Acute Pancreatitis

Haitao Gu, Franco Fortunato, Frank Bergmann, Markus W Büchler, David C Whitcomb, Jens Werner

The American Journal of Pathology (Elsevier) Germany, 01 November 2013

Gastroenterology

Key words: Pancreatic acinar cells, alcoholic acute pancreatitis, growth factor-β of acinar cells, pancreatic fibrosis

Organism: Rat

Tissue: Pancreas

Pathological State: Cancer

1821
Hypercapnia Impairs Lung Neutrophil Function and Increases Mortality in Murine Pseudomonas Pneumonia

Khalilah L Gates , Heather A Howell , Aisha Nair , Christine U Vohwinkel , Lynn C Welch , Greg J Beitel , Alan R Hauser , Jacob I Sznajder , and Peter H S Sporn

American Journal of Respiratory Cell and Molecular Biology (ATS Journals) USA, 01 November 2013

Pulmonology

Key words: arbon dioxide, pulmonary infection, reactive oxygen species, phagocytosis, inflammation

Organism: Mouse

Tissue: Lung

Pathological State: Pseudomonas Infection, Pneumonia

1822
Corelation of Lymphocytic Infiltrates with the Prognosis of Recurrent Colo-Rectal Cancer

ST Makkai-Popa, S Luncã, G Dimofte, A Vrânceanu, D Franciug, I Ivanov, F Zugun, E Târcoveanu, E Carasevici

Chirurgia (revistachirurgia) Romania, 01 November 2013

Oncology

Key words: relapse prognosis, colo-rectal cancer, quantitative assessment of immunohistochemical staining, digital image analysis, cytotoxic T cells

Organism: Human

Tissue: Colon

Pathological State: Cancer

1823
Targeting of sodium–glucose cotransporters with phlorizin inhibits polycystic kidney disease progression in Han: SPRD rats

X Wang, S Zhang, Y Liu, D Spichtig, S Kapoor, H koepsell, N Mohebbi, S Sergerer, AL Serra, D Rodriguez, O Devuyst, C Mei, RP Wüthrich

Kidney international (Elsevier) Switzerland, China, Germany, 01 November 2013

Nephrology

Key words: polycystic, phlorizin, rat, sodium–glucose cotransport

Organism: Rat

Tissue: Kidney

Pathological State: Kidney Disease

1824
Renal Heparan Sulfate Proteoglycans Modulate Fibroblast Growth Factor 2 Signaling in Experimental Chronic Transplant Dysfunction

Kirankumar Katta, Miriam Boersema, Saritha Adepu, Heleen Rienstra, Johanna WAM Celie, Rik Mencke, Grietje Molema, Harry van Goor, Jo HM Berden, Gerjan Navis, Jan-Luuk Hillebrands, Jacob van den Born

The American Journal of Pathology (Elsevier) The Netherlands, 01 November 2013

Transplantation Medicine

Key words: Renal transplantation, proteoglycans, chronic transplant dysfunction, laser-microdissected glomeruli

Organism: Rat

Tissue: Kidney

Pathological State: Chronic Transplant Dysfunction, Organ Transplantation

1825
AKIP1, a cardiac hypertrophy induced protein that stimulates cardiomyocyte growth via the Akt pathway

H Yu, W Tigchelaar, B Lu, WH van Gilst, RA De Boer, B Daan Westenbrink, HHW Sillje

International Journal of Molecular Sciences (MDPI) The Netherlands, China, 28 October 2013

Cardiology

Key words: cardiac hypertrophy, AKIP1, Akt, kinase, remodeling

Organism: Rat

Cell Line: Neonatal rat ventricular cardiomyocytes

1826
Regulation of the calcium-sensing receptor expression by 1,25-dihydroxyvitamin D3, interleukin-6, and tumor necrosis factor alpha in colon cancer cells

Irfete S Fetahu, Doris M Hummel, Teresa Manhardt, Abhishek Aggarwal, Sabina Baumgartner-Parzer, Eniko Kállay

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, 28 October 2013

Oncology

Key words: Calcium-sensing receptor, colon cancer, tumor necrosis factor alpha, interleukin, 1, 25-dihydroxyvitamin D3, Inflammation

Organism: Human

Cell Line: Caco-2 Cells

1827
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie

Oncology research and treatment (Karger) Austria, 22 October 2013

Oncology

1828
Effects on tumor development and metastatic dissemination by the NKG2D lymphocyte receptor expressed on cancer cells

A El-Gazzar, X Cai, R S Reeves, Z Dai, A Caballero-Benitez, D L McDonald, J Vazquez, T A Gooley, G E Sale, T Spies and V Groh

Oncogene (Nature) USA, 21 October 2013

Oncology

Key words: Breast cancer, Metastasis, Oncogene proteins, Oncogenesis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1829
Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation

Marco Peviani, Eleonora Salvaneschi, Leonardo Bontempi, Alessandro Petese, Antonio Manzo, Daniela Rossi, Mario Salmona, Simona Collina, Paolo Bigini, Daniela Curti

Neurobiology of Disease (Elsevier) Italy, 16 October 2013

Neuroscience

Key words: Sigma-1 receptor, motor neurons, BDNF, reactive gliosis, neurodegeneration, obbler

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Motor Neuron Disease

1830
Overexpression of the Transcriptional Repressor Complex BCL-6/BCoR Leads to Nuclear Aggregates Distinct from Classical Aggresomes

Elisabeth Buchberger, Miriam El Harchi, Dietmar Payrhuber, Anna Zommer, Dominic Schauer, Ingrid Simonitsch-Klupp, Martin Bilban, Christine Brostjan

PLoS One (PLOS) Austria, 11 October 2013

Cell Biology

Key words: Transfection, chaperone proteins, heat shock response, plasmid construction, cell staining, immunostaining, nuclear bodies, protein structure

Organism: Human

Cell Line: Primary Ecs

1831
Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo

Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Yi-An Chen, Yi-Shiou Chiou, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang

PLoS One (PLOS) Taiwan, 10 October 2013

Oncology

Key words: Cancer treatment, autophagic cell death, breast cancer, DNA damage, apoptosis, metastasis, fluorescence microscopy, DNA repair

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

1832
Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis

H Gu, J Werner, F Bergmann, DC Whitcomb, MW Büchler, F Fortunato

Cell Death & Disease (Nature) Germany, USA, 03 October 2013

Gastroenterology

Key words: Acute pancreatitis, Inflammation, Necroptosis

Organism: Rat, Human

Tissue: Pancreas

Pathological State: Pancreatitis

1833
Characterization of T Cell Receptors of Th1 Cells Infiltrating Inflamed Skin of a Novel Murine Model of Palladium-Induced Metal Allergy

Hiroshi Kobayashi, Kenichi Kumagai, Takanori Eguchi, Hiroaki Shigematsu, Kazutaka Kitaura, Mitsuko Kawano, Tatsuya Horikawa, Satsuki Suzuki, Takaji Matsutani, Kouetsu Ogasawara, Yoshiki Hamada, Ryuji Suzuki

PLoS One (PLOS) Japan, 03 October 2013

Allergy Research

Key words: T cells, allergies, T cell receptors, polymerase chain reaction, cytokines, inflammation, chemokines, sequence analysis

Organism: Mouse

1834
Comparison of Interleukin-17- Producing Cells in Different Clinical Types of Alopecia Areata

Tojo G, Fujimura T, Kawano M, Ogasawara K, Kambayashi Y,Furudate S, Mizuashi M, Aiba S

Dermatology (Karger) Japan, 01 October 2013

Dermatology

Key words: Alopecia areata Interleukin-17 Interferon Acute, diffuse and total alopecia

Organism: Human

Tissue: Skin

Pathological State: Alopecia Areata

1835
Expression Of CD8 Is Associated With Non-Common Type Morphology And Outcome In Pediatric Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma

Dmitriy Abramov, Ilske Oschlies, Martin Zimmermann, Dmitriy Konovalov, Christine Damm-Welk, Wilhelm Wössmann, Wolfram Klapper

Haematologica (Ferrata Storti Foundation) Germany, Russia, 01 October 2013

Oncology

Key words: Anaplastic lymphoma kinase, CD30-positive T-cell lymphoma, vinblastine, autologous, allogeneic hematopoietic stem cell transplantation

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

1836
Up-Regulation of SOX9 in Sertoli Cells from Testiculopathic Patients Accounts for Increasing Anti-Mullerian Hormone Expression via Impaired Androgen Receptor Signaling

Kuo-Chung Lan, Yen-Ta Chen, Chawnshang Chang, Yung-Chiao Chang, Hsin-Jung Lin, Ko-En Huang, Hong-Yo Kang

PLoS One (PLOS) Taiwan, USA, 01 October 2013

Endocrinology

Key words: Sertoli cells, testes, androgens, spermatogenesis, reverse transcriptase-polymerase chain reaction, testosterone, adults, germ cells

Organism: Human

Tissue: Testis

Pathological State: Sertoli-cell-only syndrome

1837
Digital immunohistochemistry: new horizons and practical solutions in breast cancer pathology

Arvydas Laurinavicius, Justinas Besusparis, Justina Didziapetryte, Gedmante Radziuviene, Raimundas Meskauskas Aida Laurinaviciene

Diagnostic Pathology (BioMed Central) Lithuania, 30 September 2013

Oncology

Key words: Breast cancer, Immunohistochemistry (IHC) biomarkers, tissue microarray

Organism: Human

Tissue: Breast

Pathological State: Cancer

1838
Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells

Stephan Blüml, Martin Friedrich, Tobias Lohmeyer, Emine Sahin, Victoria Saferding, Julia Brunner, Antonia Puchner, Peter Mandl, Birgit Niederreiter, Josef S Smolen, Gernot Schabbauer, Kurt Redlich

Annals of the Rheumatic Diseases (BMJ Journals) Austria, 27 September 2013

Rheumatology

Key words: Rheumatic diseases, osteoclasts, Phosphoinositide-3-Kinase, Phosphatase and tensin homolog

Organism: Mouse

Tissue: Joint Tissue, Bone

1839
Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate

Morizane A, Doi D, Kikuchi T, Okita K, Hotta A, Kawasaki T, Hayashi T, Onoe H, Shiina T, Yamanaka S, Takahashi J

Stem Cell Reports (Cell Press) Japan, 26 September 2013

Transplantation Medicine

Organism: Monkey

Tissue: Brain

1840
Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients - a study of the OVCAD consortium

Anna Bachmayr-Heyda, Stefanie Aust, Georg Heinze, Stephan Polterauer, Christoph Grimm, Elena Ioana Braicu, Jalid Sehouli, Sandrina Lambrechts, Ignace Vergote, Sven Mahner, Dietmar Pils, Eva Schuster, Theresia Thalhammer, Reinhard Horvat, Carsten Denkert, Robert Zeillinger, Dan Cacsire Castillo-Tong

BMC Cancer (BioMed Central) Austria, Germany, Belgium, 17 September 2013

Oncology

Key words: Epithelial ovarian cancer, Cytotoxic T cells, Tumor proliferation, Prognostic impact, Residual tumor

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

1841
A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis

Jimin Shin, Jang Choon Lee, Kwan-Hyuck Baek

Cancer Letters (Elsevier) South Korea, 16 September 2013

Oncology

Key words: Down syndrome, cancer, angiogenesis, Dscr1, Spontaneous lung tumorigenesis

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

1842
Contribution of Toll-Like Receptor 2 to the Innate Response against Staphylococcus aureus Infection in Mice

Yimin, Masashi Kohanawa, Songji Zhao, Michitaka Ozaki,Sanae Haga, Guangxian Nan, Yuji Kuge, Nagara Tamaki

PLoS One (PLOS) Japan, China, 13 September 2013

Immunology

Key words: Staphylococcus aureus, macrophages, cytokines, bacterial pathogens, toll-like receptors, neutrophils, gene expression, blood

Organism: Mouse

Tissue: Liver

Pathological State: Staphylococcus aureus Infection

1843
Comprehensive characterizations of nanoparticle biodistribution following systemic injection in mice

WY Liao, HJ Li, MY Chang, ACL Tang, AS Hoffman, PCH Hsieh

Nanoscale (Royal Society of Chemistry) Taiwan, USA, 06 September 2013

Nanomedicine

Organism: Mouse

Tissue: Brain, Heart, Lung, Liver, Spleen, Kidney, Skin

1844
Digital microscopy assessment of angiogenesis in different breast cancer compartments

Haisan A, Rogojanu R, Croitoru C, Jitaru D, Tarniceriu C, Danciu M, Carasevici E

BioMed Research International (Hindawi Publishing Corporation) Romania, Austria, 01 September 2013

Medical Image Analysis

Key words: Tumour angiogenesis, microvessel density, breast cancer, tumour associated stroma, tumour parenchyma, tumour invasive front.

Organism: Human

Tissue: Breast

Pathological State: Cancer

1845
In vitro and in vivo uptake study of Escherichia coli Nissle 1917 bacterial ghosts: cell-based delivery system to target ocular surface diseases

Elisabeth Stein, Aleksandra Inic-Kanada, Sandra Belij, Jacqueline Montanaro, Nora Bintner, Simone Schlacher, Ulrike Beate Mayr, Werner Lubitz, Marijana Stojanovic, Hristo Najdenski, Talin Barisani-Asenbauer

Investigative Ophthalmology & Visual Science (ARVO Journals) Austria, Serbia, Bulgaria, 01 September 2013

Microbiology

Organism: Guinea Pig

Tissue: Eye

1846
Expression of E-cadherin, Twist, and p53 and their prognostic value in patients with oral squamous cell carcinoma

Chi-Chen Fan, Tao-Yeuan Wang, Yen-An Cheng, Shih Sheng Jiang, Chien-Wen Cheng, Alan Yueh-Luen Lee, Ting-Yu Kao

Journal of Cancer Research and Clinical Oncology (Springer) Taiwan, 30 August 2013

Oncology

Key words: Ttwist expression, betel quid, betel quid chewing, oscc tissue, reduced e-cadherin, oscc tumor, oral cancer, oral squamous cell carcinoma, oral carcinogenesis, neck cancer, oral epithelium, emt marker, bladder cancer, e-cadherin promoter, emt transcription

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

1847
Involvement of the Serine Protease Inhibitor, SERPINE2, and the Urokinase Plasminogen Activator in Cumulus Expansion and Oocyte Maturation

Chung-Hao Lu, Robert Kuo-Kuang Lee, Yuh-Ming Hwu, Ming-Huei Lin, Ling-Yu Yeh, Ying-Jie Chen, Shau-Ping Lin, Sheng-Hsiang Li

PLoS One (PLOS) Taiwan, 30 August 2013

Reproductive Medicine

Key words: Oocytes, small interfering RNAs, extracellular matrix, immune serum, ovaries, vector cloning, complementary DNA, gene expression

Organism: Human

Tissue: Ovaries

1848
Glycogen synthase kinase-3β–mediated CCAAT/enhancer-binding protein delta phosphorylation in astrocytes promot es migration and activation of microglia/macrophages

Chiung-Yuan Ko, Wen-Ling Wang, Shao-Ming Wang, Yu-Yi Chu, Wen-Chang Chang, Ju-Ming Wang

Neurobiology of aging (Elsevier) Taiwan, Japan, 29 August 2013

Neuroscience

Key words: Alzheimer's disease, CEBPD, GSK3ß, astrocytes, microglia

Organism: Mouse

Tissue: Brain

1849
Human Cytomegalovirus UL76 Elicits Novel Aggresome Formation via Interaction with S5a of the Ubiquitin Proteasome System

Shin-Rung Lin, Meei Jyh Jiang, Hung-Hsueh Wang, Cheng-Hui Hu, Ming-Shan Hsu, Edward Hsi, Chang-Yih Duh, Shang-Kwei Wang

Journal of Virology (American Society for Microbiology) China, 21 August 2013

Virology

Key words: Cytomegalovirus

Organism: Human

Cell Line: HEK293T cells

1850
Neohesperidin attenuates cerebral ischemia–reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway

Journal of Asian Natural Products Research (Taylor and Francis) China, 16 August 2013

Neuroscience

Key words: Cerebral ischemia

1851
Panton-Valentine Leukocidin Facilitates the Escape of Staphylococcus aureus From Human Keratinocyte Endosomes and Induces Apoptosis

Chia-Yu Chi, Chia-Chun Lin, I-Chuang Liao, Yi-Chuan Yao, Fan-Ching Shen, Ching-Chuan Liu, Chiou-Feng Lin

The Journal of Infectious Diseases (Oxford University Press) Taiwan, 15 August 2013

Microbiology

Key words: Endosome keratinocyte, Panton-Valentine leukocidin, Staphylococcus aureus

Organism: Rabbit

Tissue: Skin

1852
Circulating alpha-klotho levels are not disturbed in patients with type 2 diabetes with and without macrovascular disease in the absence of nephropathy

Joris van Ark, Hans-Peter Hammes, Marcory C R F van Dijk, Marc G Vervloet, Bruce H R Wolffenbuttel, Harry van Goor, Jan-Luuk Hillebrands

Cardiovascular Diabetology (Springer) The Netherlands, Germany, 14 August 2013

Dermatology

Key words: Vascular, diabetes

Organism: Mouse

Tissue: Kidney

Pathological State: Diabetes

1853
Carboxyl-Terminal Modulator Protein Positively Regulates Akt Phosphorylation and Acts as an Oncogenic Driver in Breast Cancer

Yu-Peng Liu, Wen-Chi Liao, Luo-Ping Ger, Jiun-Chin Chen, Tai-I Hsu, Yu-Cheng Lee, Hong-Tai Chang, Yu-Chia Chen, Yi-Hua Jan, Kuen-Haur Lee, Yu-Hao Zeng, Michael Hsiao, Pei-Jung Lu

Cancer Research (AACR Publications) Taiwan, 13 August 2013

Oncology

Key words: Tumorigenesis, cancer cells, carboxy-terminal modulator protein, Akt serine/threonine kinase

Organism: Human

Tissue: Breast

Pathological State: Cancer

1854
A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

Karoline Kollmann, Gerwin Heller, Christine Schneckenleithner, Wolfgang Warsch, Ruth Scheicher, Rene G Ott, Markus Schäfer, Sabine Fajmann, Michaela Schlederer, Ana-Iris Schiefer, Ursula Reichart, Matthias Mayerhofer, Christoph Hoeller, Sabine Zöchbauer-Müller, Dontscho Kerjaschki, Christoph Bock, Lukas Kenner, Gerald Hoefler, Michael Freissmuth, Anthony R Green, Richard Moriggl, Meinrad Busslinger, Marcos Malumbres, Veronika Sexl

Cancer Cell (Cell Press) Austria, UK, Spain, 12 August 2013

Oncology

Key words: Cell cycle kinase CDK6, pro-angiogenic factor VEGF-A, tumor suppressor p16INK4a

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1855
Quantitative magnetization transfer MRI of desmoplasia in pancreatic ductal adenocarcinoma xenografts

Weiguo Li, Zhuoli Zhang, Jodi Nicolai, Guang-Yu Yang, Reed A Omary, Andrew C Larson

NMR in Biomedicine (Wiley) USA, 12 August 2013

Oncology

Key words: Quantitative magnetization transfer, bound proton fraction, desmoplasia, pancreatic cancer, xenograft

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1856
Entry of human rhinovirus 89 via ICAM-1 into HeLa epithelial cells is inhibited by actin skeleton disruption and by bafilomycin

Beatrix Pfanzagl, Daniel Andergassen, Johanna Edlmayr, Katarzyna Niespodziana, Rudolf Valenta, Dieter Blaas

Archives of Virology (Springer) Austria, 04 August 2013

Virology

Key words: Hela cell, transferrin, rhabdomyosarcoma, confocal immunofluorescence microscopy, cholesterol depletion, dextran, skeletal muscle cell, stress fiber formation, actin aggregate, lipid raft, breast cancer cell line, infected hela cell, actin patch, rock inhibitor, capsid protein

Organism: Human

Cell Line: HeLa cells

1857
An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

Alicia S Chung, Xiumin Wu, Guanglei Zhuang, Hai Ngu, Ian Kasman, Jianhuan Zhang, Jean-Michel Vernes, Zhaoshi Jiang, Y Gloria Meng, Franklin V Peale, Wenjun Ouyang and Napoleone Ferrara

Nature Medicine (Nature) USA, 04 August 2013

Oncology

Key words: Cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

1858
Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis

Yasuyuki Shigematsu, Tohru Niwa, Emil Rehnberg, Takeshi Toyoda, Satoshi Yoshida, Akiko Mori, Mika Wakabayashi, Yoichiro Iwakura, Masao Ichinose, Yong-Joon Kim, Toshikazu Ushijima

Cancer Letters (Elsevier) Japan, South Korea, 03 August 2013

Oncology

Key words: Interleukin-1ß, gastric cancer, helicobacter pylori infection, inflammation

Organism: Mouse

Tissue: Stomach

Pathological State: Cancer, Helicobacter pylori infection

1859
Impact of constant storage temperatures and multiple warming cycles on the quality of stored red blood cells

T Wagner, M-A Pabst, G Leitinger, U Reiter, N Kozma, G Lanzer, B Huppertz

VoxSanguinis (Wiley) Austria, 02 August 2013

Hematology

Key words: Electron microscopy, quality, RBC, storage, temperature.

Organism: Human

Cell Line: Red blood cells

1860
Decreased hippocampal MR/GR ratio is associated with low-birth weight in Cynomolgus macaque neonates

JP Buschdorf, SX Ong, K Chng, MJ Meany

Journal of Molecular Endocrinology (Society for Endocrinology) Singapore, 01 August 2013

Reproductive Medicine

Key words: MR:GR ratio, cynomolgus macaque, glucocorticoid receptor, low birth weight

Organism: Monkey

Tissue: Brain

1861
Mobilizing monocytes to cross-present circulating viral antigen in chronic infection

Adam J Gehring, Muzlifah Haniffa, Patrick T Kennedy, Zi Zong Ho, Carolina Boni, Amanda Shin, Nasirah Banu, Adeline Chia, Seng Gee Lim, Carlo Ferrari, Florent Ginhoux, Antonio Bertolett

The Journal of Clinical Investigation (American Society for Clinical Investigation) Singapore, UK, Italy, 01 August 2013

Immunology

Organism: Human

Cell Line: PBMCs

1862
Infliximab induces downregulation of the IL-12/IL-23 axis in 6-sulfo-LacNac (slan)+ dendritic cells and macrophages

Patrick M Brunner, Frieder Koszik, Bärbel Reininger, Madeleine L Kalb, Wolfgang Bauer, Georg Stingl

Journal of Allergy and Clinical Immunology (Elsevier) Austria, 25 July 2013

Allergy Research

Key words: Psoriasis, myeloid dendritic cells, 6-sulfo-LacNac, IL-12p40, TNF-a

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

1863
Association of gamma-glutamyltransferase with severity of disease at diagnosis and prognosis of ovarian cancer

C Grimm, G Hofstetter, S Aust, I Mutz-Dehbalaie, M Bruch, G Heinze, J Rahhal-Schupp, A Reinthaller, N Concin, S Polterauer

British Journal of Cancer (Nature) Austria, USA, 16 July 2013

Oncology

Key words: Ovarian cancer, Prognostic markers

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

1864
High resolution MRI for non-invasive mouse lymph node mapping

Zhuoli Zhang , Daniel Procissi, Weiguo Li, Dong-Hyun Kim, Kangan Li, Guohong Han, Yi Huan, Andrew C Larson

Journal of Immunological Methods (Elsevier) USA, China, 11 July 2013

Immunology

Key words: Mouse, Lymph node, Lymphatic drainage, India ink, Magnetic resonance imaging

Organism: Mouse

Tissue: Lymphoid Tissue

1865
A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia

Stuart J Wong, Bruce Campbell, Becky Massey, Denis P Lynch, Ezra EW Cohen, Elizabeth Blair, Rebecca Selle, Julia Shklovskaya, Borko D Jovanovic, Silvia Skripkauskas, Alexander Dew, Peter Kulesza, Vamsi Parimi, Raymond C Bergan, e, Eva Szabo

Oral Oncology (Elsevier) USA, 08 July 2013

Oncology

Key words: Leukoplakia, aminolevulinic acid, photodynamic therapy, phase I, laser

Organism: Human

Tissue: Mucosa

Pathological State: Leukoplakia

1866
Vascular Injury Involves the Overoxidation of Peroxiredoxin Type II and Is Recovered by the Peroxiredoxin Activity Mimetic That Induces Reendothelialization

Dong Hoon Kang, Doo Jae Lee, Jiran Kim, Joo Young Lee, Hyun-Woo Kim, Kihwan Kwon, W Robert Taylor, Hanjoong Jo, Sang Won Kang

Circulation (AHA Journals) USA, South Korea, 02 July 2013

Cardiology

Key words: Coronary restenosis, endothelium, peroxiredoxins, reactive oxygen species, receptor protein-tyrosine kinases

Organism: Human

Tissue: Blood Vessels

1867
Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species

CW Cheng, CY Kuo, CC Fan, WC Fang, SS Jiang, YK Lo, TY Wang, MC Kao, AYL Lee

Cell Death & Disease (Nature) Taiwan, 20 June 2013

Oncology

Key words: Apoptosis, Cancer metabolism, Pathogenesis

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

1868
THU0094 Treatment with BGP-15, a Novel Insulin Sensitizer Attenuates Collagen-Induced Arthritis in DBA/1 Mice

P Mandl, S Hayer, S Blüml, V Saferding, D Sykoutri, C Antus, A Szabo, J Smolen, K Redlich

Annals of the Rheumatic Diseases (BMJ Journals) Austria, Hungary, 15 June 2013

Rheumatology

Key words: Arthritis

1869
HPV16 activates the AIM2 inflammasome in keratinocytes

M Reinholz, Y Kawakami, S Salzer, A Kreuter, Y Dombrowski, S Koglin, S Kresse, T Ruzicka, J Schauber

Archives of Dermatological Research (Springer) Germany, 14 June 2013

Dermatology

Key words: Hpv16 dna, aim2 inflammasome, cytosolic dna sensor, inflammasome activation, anal intraepithelial neoplasium, hpv dna, hpv infection, il-1 release, amphotericin, caspase-1 activation, cutaneous wart, il-1 secretion, gentamicin, viral dna, hpv16 18

Organism: Human

Tissue: Skin

Pathological State: HPV Infection

1870
Glia, Poster. Cell proliferation, lineages and differentation

C Fenger, M Thomassen, B Emery, T Kuhlmann, TA Kruse, B Finsen

GLIA (Wiley) Denmark, Austria, Australia, 14 June 2013

Neuroscience

Key words: Cell proliferation, lineages, differentiation

1871
A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus

S Koh, N Shimasaki, R Suwanarusk, ZZ Ho, A Chia, N Banu, S Wu Howland, AS Meoy Ong, AJ Gehring, H Stauss, L Renia, M Sällberg, D Campana, A Bertoletti

Molecular Therapy-Nucleic Acids (Cell Press) Singapore, Sweden, USA, UK, 12 June 2013

Immunology, Virology

Key words: hepatitis B virus, hepatocellular carcinoma, mRNA electroporation, TCR gene therapy

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

1872
In vivo bioluminescence reporter gene imaging for the activation of neuronal differentiation induced by the neuronal activator neurogenin 1 (Ngn1) in neuronal precursor cells

Hyun Jeong Oh, Do Won Hwang, Hyewon Youn, Dong Soo Lee

European Journal of Nuclear Medicine and Molecular Imaging (Springer) South Korea, 11 June 2013

Neuroscience

Key words: Reporter gene imaging, vector complex, neuronal differentiation, neuronal marker map2, gaussia luciferase, stem cell therapy, human nsc, pluripotent stem cell, grafted stem cell, neural precursor cell, hela cell, neurite outgrowth, nucleic acid delivery, nude mouse, luciferase signal

Organism: Human

Cell Line: F11 cells

1873
SYK Inhibition Modulates Distinct PI3K/AKT- Dependent Survival Pathways and Cholesterol Biosynthesis in Diffuse Large B Cell Lymphomas

Linfeng Chen, Stefano Monti ,Przemyslaw Juszczynski, Jing Ouyang, Bjoern Chapuy, Donna Neuberg, John G Doench, Agata M Bogusz,Thomas M Habermann, Ahmet Dogan, Thomas E Witzig, Jeffery L Kutok, Scott J Rodig, Todd Golub, Margaret A Shipp

Cancer Cell (Cell Press) USA, 10 June 2013

Oncology

Key words: B cell receptor, diffuse large B cell lymphoma

Organism: Human

Pathological State: Cancer

Cell Line: DLBCL cells

1874
Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4

Prabakaran Nagarajan, Zhongqi Ge, Bianca Sirbu, Cheryl Doughty, Paula A Agudelo Garcia, Michaela Schlederer, Anthony T Annunziato, David Cortez, Lukas Kenner, Mark R Parthun

PLoS Genetics (PLOS) USA, Austria, 06 June 2013

Genetics

Key words: Histones , Acetylation , Chromatin , Lysine , DNA damage , Mouse models , DNA replication , Neonates

Organism: Mouse

Tissue: Whole Organism

1875
Clinical significance and evolution of hepatic HBsAg expression in HBeAg-positive patients receiving interferon therapy

Tung-Hung Su, Chun-Jen Liu, Hung-Chih Yang, Yung-Ming Jeng, Huei-Ru Cheng, Chen-Hua Liu, Tai-Chung Tseng, Thai-Yen Ling, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao

Journal of Gastroenterology (Springer) Taiwan, 05 June 2013

Gastroenterology

Key words: Hbsag decline, hbsag expression, on-treatment hbsag, hbsag titer, hbsag clearance, serum hbsag, hbeag loss, hbeag-negative chb, hbv genotype, hbv dna, serum hbv-dna, hbeag-positive chb, hbsag quantification, architect hbsag, viral load

Organism: Human

Tissue: Liver

Pathological State: Hepatitis B Virus Infection

1876
Quantitative Evaluation of Stem Cell Grafting in the Central Nervous System of Mice by In Vivo Bioluminescence Imaging and Postmortem Multicolor Histological Analysis

Kristien Reekmans, Nathalie De Vocht, Jelle Praet, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Annemie Van der Linden, Zwi Berneman, Peter Ponsaerts

Imaging and Tracking Stem Cells (Springer) Belgium, 04 June 2013

Stem Cell Research

Key words: Neural stem cells, mesenchymal stromal cells eGFP, luciferase, cell transplantation, brain, bioluminescence imaging, histology, microglia, astrocytes

1877
Enhanced inhibition of prostate tumor growth by dual targeting the androgen receptor and the regulatory subunit type iα of protein kinase a in vivo

Iris E Eder, Martina Egger , Hannes Neuwirt , Christof Seifarth , Danilo Maddalo , Andreas Desiniotis, Georg Schäfer, Martin Puhr, Jasmin Bektic, Andrew C B Cato and Helmut Klocker

International Journal of Molecular Sciences (MDPI) Austria, Germany, 04 June 2013

Oncology

Key words: androgen receptor, cAMP-dependent protein kinase A, regulatory subunit type Iα, prostate cancer, antisense molecules, dual targeting, LNCaP xenografts, castration resistance

Organism: Mouse

Tissue: Prostate, Xenograft Tumor

Pathological State: Cancer

1878
Smooth muscle cell transplantation improves bladder contractile function in streptozocin-induced diabetic rats

Chaitanya Gopinath, Peter Ponsaerts, Erik Fransen, Nele Boeykens, Patrick Pauwels, Jean-Jacques Wyndaele

Cytotherapy (Elsevier) Belgium, 01 June 2013

Transplantation Medicine

Key words: Bladder smooth muscle cells, cell graft survival, cell transplantation, contractile function, diabetes, in vivo cystometry

Organism: Rat

Tissue: Bladder

Pathological State: Diabetes

1879
Biocompatible fluorescent nanoparticles for in vivo stem cell tracking

Lidia Cova, Paolo Bigini, Valentina Diana, Leopoldo Sitia, Raffaele Ferrari, Ruggiero Maria Pesce, Rushd Khalaf, Patrizia Bossolasco, Paolo Ubezio, Monica Lupi, Massimo Tortarolo, Laura Colombo, Daniela Giardino, Vincenzo Silani, Massimo Morbidelli, Mario Salmona and Davide Moscatelli

Nanotechnology (IOP Science) Italy, Switzerland, 20 May 2013

Nanomedicine

Key words: fluorescent nanoparticles, in vivo stem cell tracking, hAFCs, methyl methacrylate (MMA)

Organism: Human

Cell Line: hAFC cells

1880
Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents

An Ning Cheng, Shih Sheng Jiang,Chi-Chen Fan, Yu-Kang Lo, Chan-Yen Kuo, Chung-Hsing Chen, Ying-Lan Liu, Chun-Chung Lee, Wei-Shone Chen, Tze-Sing Huang, Tao-Yeuan Wang, Alan Yueh-Luen Lee

Cancer Letters (Elsevier) Taiwan, 16 May 2013

Oncology

Key words: Cdc7, oral cancer, prognostic marker, chemotherapy resistance

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

1881
Identification and Characterization of Poorly Differentiated Invasive Carcinomas in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis

Karen E Hunter, Marsha L Quick, Anguraj Sadanandam,Douglas Hanahan, Johanna A Joyce

PLoS One (PLOS) USA, Switzerland, 14 May 2013

Oncology

Key words: Insulin, differentiated tumors, invasive tumors, cell staining, insulinoma, immunofluorescence staining, carcinomas, cell differentiation

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

1882
Determination of tumor-infiltrating CD8+ lymphocytes in human ovarian cancer

Aust S, Bachmayr-Heyda A, Pils D, Zhao L, Tong W, Berger A, Fogel M, Thalhammer T, Sehouli J, Horvat R, Zeillinger R, Castillo-Tong DC

International Journal of gynecological pathology (Wolters Kluwer) Austria, 10 May 2013

Oncology

Key words: Tumor-infiltrating immune cells, ovarian cancer, CD8+ lymphocytes

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

1883
Gaseous Hydrogen Sulfide Protects against Myocardial Ischemia-Reperfusion Injury in Mice Partially Independent from Hypometabolism

Pauline M Snijdr , Rudolf A de Boer, Eelke M Bos, Joost C van den Born, Willem-Peter T Ruifrok, Inge Vreeswijk-Baudoin, Marcory C R F van Dijk, Jan-Luuk Hillebrands,Henri G D Leuvenink, Harry van Goor

PLoS One (PLOS) The Netherlands, 10 May 2013

Cardiology

Key words: Reperfusion, necrosis, blood pressure, fibrosis, heart rate, granulocytes, heart , oxygen

Organism: Rat

Pathological State: Myocardial Ischemia

Cell Line: H9c2 cells

1884
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors

KE Hunter, C Palermo, JC Kester, K Simpson, JP Li, LH Tang, DS Klimstra, I Vlodavsky and JA Joyce

Oncogene (Nature) USA, Sweden, Israel, 06 May 2013

Oncology

Key words: Lymphangiogenesis, Oncogenesis, Pancreatic cancer

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

1885
Selected Abstracts from the World Conference on Interventional Oncology (WCIO) 2013

Journal of Vascular and Interventional Radiology (Elsevier) , 01 May 2013

Oncology

1886
Sex differences in IRF5 levels and implications for pDC IFN{alpha} response (P1365)

Morgane Griesbeck, Phillip Tomezsko, Erin Doyle, Michael Sirignano,Thomas Diefenbach, Marcus Altfeld, Judy Chang

The Journal of Immunology (American Association of Immunologists) USA, 01 May 2013

Immunology

Key words: IRF5, Sex differences, pDC IFNα, HIV-1

Pathological State: HIV Infection

1887
Nuclear Localization of CD26 Induced by a Humanized Monoclonal Antibody Inhibits Tumor Cell Growth by Modulating of POLR2A Transcription

Kohji Yamada, Mutsumi Hayashi, Hiroko Madokoro, Hiroko Nishida, Wenlin Du, Kei Ohnuma, Michiie Sakamoto, Chikao Morimoto, Taketo Yamada

PLoS One (PLOS) Japan, 29 April 2013

Oncology

Key words: Cancer treatment, mesothelioma, endocytosis, nuclear membrane, small interfering RNAs, immunoprecipitation, immunoblot analysis, cell membranes

Organism: Human

Pathological State: Cancer

Cell Line: Malignant mesothelioma cell lines

1888
Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis

E Gounaris, J Martin, Y Ishihara, MW Khan, G lee, P Sinh, EZ Chen, M Angarone, R Weissleder, K Khazaie, TA Barrett

Inflammatory bowel Disease (Oxford University Press) USA, 15 April 2013

Gastroenterology

Key words: dysplasia, colitis, macrophages, cathepsin activity, fluorescence endoscopy

Organism: Human

Tissue: Colon

Pathological State: Colitis

1889
Intra-voxel incoherent motion MRI in rodent model of diethylnitrosamine-induced liver fibrosis

Yue Zhang, Ning Jin, Jie Deng, Yang Guo, Sarah B White, Guang-Yu Yang, Reed A Omary, Andrew C Larson

Magnetic Resonance Imaging (Elsevier) USA, 15 April 2013

Medical Imaging

Key words: Intra-Voxel Incoherent Motion, Diffusion weighted MRI, Liver fibrosis

Organism: Rat

Tissue: Liver

Pathological State: Liver Fibrosis

1890
Non-Cell-Autonomous Tumor Suppression by p53

Amaia Lujambio, Leila Akkari, Janelle Simon, Danielle Grace, Darjus F Tschaharganeh, Jessica E Bolden, Zhen Zhao, Vishal Thapar, Johanna A Joyce, Valery Krizhanovsky, Scott W Lowe

CELL (Cell Press) USA, Israel, 11 April 2013

Oncology

Key words: p53 tumor suppressor, hepatic stellate cells, hepatocellular carcinoma, premalignant cells

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

1891
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment

Vernon T Phan, Xiumin Wu, Jason H Cheng, Rebecca X Sheng, Alicia S Chung, Guanglei Zhuang, Christopher Tran, Qinghua Song, Marcin Kowanetz, Amy Sambrone, Martha Tan, Y Gloria Meng, Erica L Jackson, Franklin V Peale, Melissa R Junttila, Napoleone Ferrara

PNAS (PNAS) USA, 09 April 2013

Oncology

Key words: Agiogenesis microenvironment tyrosine kinase

1892
Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer

Julia Höbaus, Doris M Hummel, Ursula Thiem, Irfete S Fetahu, Abhishek Aggarwal, Leonhard Müllauer, Gerwin Heller, Gerda Egger, Ildiko Mesteri, Sabina Baumgartner-Parzer, Enikö Kallay

International Journal of Cancer (Wiley) Austria, 05 April 2013

Oncology

Key words: CYP24A1, colorectal cancer, 20q13.2, methylation, proliferation

Organism: Human

Tissue: Colon

Pathological State: Cancer

1893
Transcatheter delivery of sorafenib-eluting polylactide-co-glycolide microspheres: therapy response studies in a rat model of hepatocellular carcinoma

J Chen, A Sheu, RJ Lewandowski, RA Omary, L Shea, AC Larson

Journal of Vascular and Interventional Radiology (Elsevier) USA, 02 April 2013

Oncology

Key words: Sorafenib, hepatocellular carcinoma, polylactide-co-glycolide

Organism: Rat

Tissue: Liver

Pathological State: Cancer

1894
Excisional Wound Healing Is Delayed in a Murine Model of Chronic Kidney Disease

Akhil K Seth, Mauricio De la Garza, Robert C Fang, Seok J Hong, Robert D Galiano

PLoS One (PLOS) USA, 25 March 2013

Nephrology

Key words: Chronic kidney disease, wound healing, kidneys, granulation tissue, angiogenesis, inflammation, renal failure, surgical and invasive medical procedures

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

1895
Effects of Cholic Acid and its Derivatives in Experimental Arthritis

Silvia Hayer, Emina Halilbasic, Birgit Niederreiter, Martin Willburger, Peter Mandl, Victoria Saferding, Stephan Blüml, Josef Smolen, Michael Trauner, Kurt Redlich

Annals of the Rheumatic Diseases (BMJ Journals) Austria, 20 March 2013

Rheumatology

Key words: Cholesterol metabolism, Collagen-induced arthritis, nor-ursodeoxycholic acid

Organism: Mouse

Tissue: Joint Tissue, Bone

Pathological State: Rheumatoid Arthritis

1896
Do High Molecular Weight Adiponectin Levels Associate with Radiographic Progression in early Rheumatoid Arthritis and Hand Osteoarthritis?

IR Klein-Wieringa, SN Andersen, JC Kwekkeboom, L Herb-vToorn, AHM van der Helm-van Mil, I Meulenbelt, TWJ Huizinga, M Kloppenburg, REM Toes, A Ioan-Facsinay

Annals of the Rheumatic Diseases (BMJ Journals) The Netherlands, 20 March 2013

Rheumatology

Key words: Adipokines, osteoarthritis, rheumatoid arthritis

Organism: Mouse

Tissue: Bone

Pathological State: Rheumatoid Arthritis

1897
The prognostic value of estrogen receptor beta and proline-, glutamic acid- and leucine-rich protein 1 (PELP1) expression in ovarian cancer

Stefanie Aust, Peter Horak, Dietmar Pils, Sophie Pils, Christoph Grimm, Reinhard Horvat, Dan Tong, Bernd Schmid, Paul Speiser, Alexander Reinthaller, Stephan Polterauer

BMC Cancer (Springer) Austria, 14 March 2013

Oncology

Key words: Mucinous ovarian cancer, residual tumor load, mucinous eoc, eoc tissue, serous eoc, clear cell carcinoma, endometrioid tumor, breast cancer tissue, cytoreductive surgery, human eoc, endometrial cancer, serum ca-125, paraaortic lymphadenectomy, undifferentiated carcinoma, surgical staging

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

1898
PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer

Mohammad W Khan, Ali Keshavarzian, Elias Gounaris, Joshua E Melson, Eric C Cheon, Nichole R Blatner, Zongmin E Chen, Fu-Nien Tsai, Goo Lee, Hyunji Ryu, Terrence A Barrett, David J Bentrem, Philipp Beckhove, Khashayarsha Khazaie

Clinical Cancer Research (AACR Publications) USA, Germany, 13 March 2013

Oncology

Key words: Colitis, dysplasia, colorectal cancer, colonic submucosa, phosphoinositide 3-kinase

Organism: Human

Tissue: Colon

Pathological State: Colitis, Cancer

1899
Tumor STAT1 Transcription Factor Activity Enhances Breast Tumor Growth and Immune Suppression Mediated by Myeloid-derived Suppressor Cells

Laura M Hix, John Karavitis, Mohammad W Khan, Yihui H Shi, Khashayarsha Khazaie, Ming Zhang

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) USA, 13 March 2013

Oncology

Key words: Breast Cancer, immunosuppression, signal transduction, T Cell, tumor immunology, MDSC, STAT1, mouse model of breast cancer

Organism: Human, Mouse

Tissue: Breast

Pathological State: Cancer

1900
Type III Secretion of ExoU Is Critical during Early Pseudomonas aeruginosa Pneumonia

Heather A Howell, Latania K Logan, Alan R Hauser

mBio (ASM) USA, 12 March 2013

Pulmonology

Key words: Eukaryotic cells, Many Gram-negative bacteria, Pseudomonas aeruginosa

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia, Pseudomonas Infection

1901
Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation

Zhuoli Zhang, Weiguo Li, Daniel Procissi, Patrick Tyler, Reed A Omary, Andrew C Larson

Nanomedicine (Future Medicine) USA, 12 March 2013

Nanomedicine

Key words: Immunohistochemistry apoptosis, IRE-treated tumors

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1902
Late Infusion of Cloned Marrow Fibroblasts Stimulates Endogenous Recovery from Radiation-Induced Lung Injury

Mineo Iwata, David K Madtes, Kraig Abrams, Wayne J E Lamm, Robb W Glenny, Richard A Nash, Aravind Ramakrishnan, Beverly Torok-Storb

PLoS One (PLOS) USA, 08 March 2013

Regenerative Medicine

Key words: Dogs, pulmonary imaging, computed axial tomography, stem cells, fibroblasts, endothelial cells, pulmonary function, reverse transcriptase-polymerase chain reaction

Organism: Dog

Tissue: Lung

Pathological State: Radiation-induced lung injury

1903
Quantitative measurement of the androgen receptor in prepuces of boys with and without hypospadias

Renate Pichler, Gabriel Djedovic, Helmut Klocker, Isabel Heidegger, Alexander Strasak, Wolfgang Loidl, Jasmin Bektic, Viktor Skradski, Wolfgang Horninger, Josef Oswald

BJU International (Wiley) Austria, 07 March 2013

Endocrinology

Key words: Hypospadias, aetiology, androgen receptor, genetics, signalling

Organism: Human

Tissue: Prostate

Pathological State: Hypospadias

1904
FRI0270 Development of systemic lupus-like disease in regulatory T cells (TREG)-deficient scurfy mice

G Stummvoll, X Wei, H Leiss, B Niederreiter, B Heckmann, W Ulrich, A Enk, J Smolen, E Hadaschik

Annals of the Rheumatic Diseases (BMJ Journals) Austria, Germany, 01 March 2013

Rheumatology

Key words: Lupus, T cells

Organism: Mouse

Tissue: Skin

Pathological State: Lupus

1905
The 10th International Congress on SLE

McMahon M, Skaggs B, Grossman J, Sahakian L, FitzGerald J, Lourenco E, Ragavendra N, Charles-Schoeman C, Gorn A, Karpuzas G, Taylor M, Watson K, Weisman M, Wallace D, Hahn BH

Lupus (SAGE Journals) USA, 01 March 2013

Rheumatology

Key words: Pro-inflammatory HDL, subclinical atherosclerosis, NGAL (lipocalin-2)

1906
Hyaluronan enhances bone marrow cell therapy for myocardial repair after infarction

CH Chen, SS Wang, EIH Wei, TY Chu, PCH Hsieh

Molecular Therapy (Cell Press) Taiwan, 01 March 2013

Cardiology

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Infarction

1907
Human Umbilical Vein Endothelial Cells Protect Against Hypoxic-Ischemic Damage in Neonatal Brain via Stromal Cell-derived Factor 1/C-X-C Chemokine Receptor Type 4

Chia-Ching Wu, Yi-Chi Chen, Ying-Chao Chang, Lan-Wan Wang, Yung-Chieh Lin, Yi-Lun Chiang, Chien-Jung Ho, Chao-Ching Huang

Stroke (AHA Journals) Taiwan, 28 February 2013

Neuroscience

Key words: Human umbilical vein endothelial cell, neonatal brain, neurovascular unit, SDF-1/CXCR4

Organism: Rat, Human

Tissue: Brain

Pathological State: Cerebral ischemia

Cell Line: HUVECs (Human umbilical vein endothelial cells)

1908
Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound

Po-Hung Hsu, Kuo-Chen Wei, Chiung-Yin Huang, Chih-Jen Wen, Tzu-Chen Yen, Chao-Lin Liu, Ya-Tin Lin, Jin-Chung Chen, Chia-Rui Shen, Hao-Li Liu

PLoS One (PLOS) Taiwan, 27 February 2013

Nanomedicine

Key words: Viral vectors, magnetic resonance imaging , central nervous system, astrocytes, gene delivery, gene expression, acoustics, neurons

Organism: Mouse

Tissue: Brain

1909
Abatacept (CTLA-4IG) treatment reduces the migratory capacity of monocytes in patients with rheumatoid arthritis

M Bonelli, E Ferner, L Göschl, S Blüml, A Hladik, T Karonitsch, H P Kiener, R Byrne, B Niederreiter, C W Steiner, E Rath, M Bergmann, J S Smolen, C Scheinecker

Arthritis & Rheumatology (Wiley) Austria, 25 February 2013

Rheumatology

Key words: Antigen-presenting cells, CTLA-4Ig, Peripheral blood mononuclear cells

Organism: Human

Pathological State: Rheumatoid Arthritis

Cell Line: PBMCs

1910
Tumor necrosis factor–inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factor–driven model of rheumatoid arthritis

Nikolaus B Binder, Antonia Puchner, Birgit Niederreiter, Silvia Hayer, Harald Leiss, Stephan Blüml, Roman Kreindl, Josef S Smolen, Kurt Redlich

Arthritis & Rheumatology (Wiley) Austria, USA, 25 February 2013

Rheumatology

Key words: Tumor necrosis factor, osteoclastogenesis in vitro, cell–derived monocytes

Organism: Mouse

Tissue: Joint Tissue, Bone

Pathological State: Rheumatoid Arthritis

1911
Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2

Ewa Przybyt, Guido Krenning, Marja GL Brinker, Martin C Harmsen

Journal of Translational Medicine (Springer) The Netherlands, 13 February 2013

Cardiology

Key words: hl-1 cardiomyocyte, hl-1 cell, jak stat inhibitor, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation

Organism: Human

Cell Line: Cardiomyocytes

1912
Automated REcognition of Tissue-associated Erythrocytes (ARETE)—a new tool in tissue cytometry

Andreas Heindl, Alexander K Seewald, Theresia Thalhammer, Giovanna Bises, Martin Schepelmann, Hana Uhrova, Sabine Dekan, Ildiko Mesteri, Radu Rogojanu, Isabella Ellinger

Cytometry Part A (Wiley) Austria, 11 February 2013

Medical Image Analysis

Key words: Erythrocytes, immunofluorescence microscopy, autofluorescence, tissue cytometry, automated image analysis, boosted decision trees of Haar-like features, machine learning, placenta, colorectal cancer

Organism: Human

Tissue: Colon

1913
Characterization of Transcriptional Changes in ERG Rearrangement-Positive Prostate Cancer Identifies the Regulation of Metabolic Sensors Such as Neuropeptide Y

Petra Massoner, Karl G Kugler, Karin Unterberger, Ruprecht Kuner, Laurin A J Mueller, Maria Fälth, Georg Schäfer, Christof Seifarth, Simone Ecker,Irmgard Verdorfer, Armin Graber, Holger Sültmann, Helmut Klocker

PLoS One (PLOS) Austria, Germany, 04 February 2013

Oncology

Key words: Prostate cancer, gene expression, meta-analysis, prostate gland, gene regulation, microarrays, cell metabolism, glucose metabolism

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1914
Circulating Metastasis Promoting Protein S100A4 in Idiopathic Inflammatory Myopathies

L Pleštilová, O Pecha, H Mann, LA Cerezo, J Vencovský, L Šenolt

Annals of the Rheumatic Diseases (BMJ Journals) Czech Republic, 02 February 2013

Rheumatology

Key words: Protein S100A4, rheumatoid arthritis, psoriasis

1915
Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes

S Liu, G Kilic, M S Meyers, G Navarro, Y Wang, J Oberholzer, F Mauvais-Jarvis

Diabetologia (Springer) USA, China, 01 February 2013

Endocrinology

Key words: Ffunctional vessel density, human alpha cell, human islet graft, beta cell regeneration, beta cell apoptosis, islet transplantation, islet yield, sirolimus, islet engraftment, apoptotic beta cell, cultured human islet, beta cell proliferation, tacrolimus, mouse islet, insulin independence

Organism: Mouse

Tissue: Kidney

Pathological State: Diabetes

1916
Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke

YS Lee, CC Chio, CP Chang, LC Wang, PM Chiang, KC Niu, KJ Tsai

Mediators of Inflammation (Hindawi Publishing Corporation) Taiwan, 15 January 2013

Neuroscience

Organism: Rat

Tissue: Brain

Pathological State: Stroke

1917
Cystathionine γ-Lyase Protects against Renal Ischemia/Reperfusion by Modulating Oxidative Stress

Eelke M Bos, Rui Wang, Pauline M Snijder, Miriam Boersema, Jeffrey Damman, Ming Fu, Jill Moser, Jan-Luuk Hillebrands, Rutger J Ploeg, Guangdong Yang, Henri GD Leuvenin, Harry van Goor

Journal of The American Society of Nephrology (JASN) Canada, UK, The Netherlands, 02 January 2013

Nephrology

Key words: Cystathionine γ-lyase, tubulointerstitium, glomeruli, renal ischemia

1918
Tumor-specific expression of organic anion-transporting polypeptides: transporters as novel targets for cancer therapy

Veronika Buxhofer-Ausch, Lena Secky, Katrin Wlcek, Martin Svoboda, Valentinos Kounnis, Evangelos Briasoulis, Andreas G Tzakos, Walter Jaeger, and Theresia Thalhammer

Journal of drug delivery (Hindawi Publishing Corporation) Austria, Switzerland, Greece, 01 January 2013

Oncology

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

1919
The role of glucocorticoid receptors in dexamethasone-induced apoptosis of neuroprogenitor cells in the hippocampus of rat pups

CI Sze, YC Lin, YJ Lin, TH Hsieh, YM Kuo, CH Lin

Mediators of Inflammation (Hindawi Publishing Corporation) Taiwan, 01 January 2013

Neuroscience

Organism: Rat

Tissue: Brain

1920
MAGNESIUM AND ZINC INFLUENCE ON FEMALE GENITAL TRACT IN EXPERIMENTAL INDUCED DIABETES MELLITUS.

Galeş, Cristina, Nechifor, M, Stoica, B, Stan, C I, Zamfir, Carmen Lãcrãmioara

Romanian Journal of Functional and Clinical, Macro- and Microscopical Anatomy and of Anthropology () Romania, 01 January 2013

Reproductive Medicine

Pathological State: Diabetes

1921
The effect of pioglitazone on non-pregnant female genital tract in experimental diabetes mellitus

C Gales, C Zamfir, B Stoica, M Nechifor

The Medical-Surgical  Journal (revmedchir) Romania, 01 January 2013

Reproductive Medicine

Key words: DIABETES MELLITUS, STREPTOZOTOCIN, PIOGLITAZONE, OVARY

Pathological State: Diabetes

1922
Tracing Conidial Fate and Measuring Host Cell Antifungal Activity Using a Reporter of Microbial Viability in the Lung

Anupam Jhingran, Katrina B Mar, Debra K Kumasaka, Sue E Knoblaugh, Lisa Y Ngo, Brahm H Segal, Yoichiro Iwakura, Clifford A Lowell, Jessica A Hamerman, Xin Lin, Tobias M Hohl

Cell Reports (Cell Press) USA, Japan, 27 December 2012

Virology

Key words: FLARE conidia, C-type lectin receptor, leukocyte-fungal cell

Organism: Mouse

Tissue: Lung

Pathological State: Fungal Infection

1923
Comprehensive morphometric analysis of mononuclear cell infiltration during experimental renal allograft rejection

Ute Hoffmann, Tobias Bergler, Bettina Jung, Andreas Steege, Claudia Pace, Petra Rümmele, Stephan Reinhold, Bernd Krüger, Bernhard K Krämer, Bernhard Banas

Transplant Immunology (Elsevier) Germany, 23 December 2012

Transplantation Medicine

Key words: B-cells, different analysis methods, experimental renal allograft rejection, macrophages, T-cells

Organism: Rat

Tissue: Kidney

Pathological State: Allogeneic Transplantation

1924
Ectopic Pregnancy-Derived Human Trophoblastic Stem Cells Regenerate Dopaminergic Nigrostriatal Pathway to Treat Parkinsonian Rats

Tony Tung-Yin Lee, Cheng-Fang Tsai, Tsung-Hsun Hsieh, Jia-Jin Jason Chen, Yu-Chih Wang, Mi-Chun Kao, Ruey-Meei Wu, Sher Singh, Eing-Mei Tsai, Jau-Nan Lee

PLoS One (PLOS) Taiwan, 21 December 2012

Stem Cell Research

Key words: Neurons, pluripotency, flow cytometry, pregnancy, dopamine, dopaminergics, rats, cell differentiation

Organism: Rat

Tissue: Brain

Pathological State: Parkinson's Disease

1925
Enhancement of the Immunogenicity and Protective Efficacy of a Mucosal Influenza Subunit Vaccine by the Saponin Adjuvant GPI-0100

Heng Liu, Harshad P Patil, Jacqueline de Vries-Idema, Jan Wilschut, Anke Huckriede

PLoS One (PLOS) The Netherlands, 17 December 2012

Immunology

Key words: Vaccines, immunologic adjuvants, influenza, immune response, antibodies, antibody response, influenza viruses, viral vaccines

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection

1926
Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting

Kristien Reekmans, Nathalie De Vocht, Jelle Praet, Erik Fransen, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Herman Goossens, Annemie Van der Linden, Zwi Berneman, Peter Ponsaerts

Stem Cell Research & Therapy (BMC) Belgium, 14 December 2012

Stem Cell Research

Key words: Anti-APC (Adenomatous polyposis coli protein) antibody, central nervous system, enhanced green fluorescent protein, neuronal nuclei

Organism: Mouse

Tissue: Brain

1927
CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling

Kuo-Hua Tung, Cheng-Wei Lin, Chun-Chen Kuo, Li-Tzu Li, Ya-Hsun Kuo, Chung-Wu Lin, Han-Chung Wu

Cancer Letters (Elsevier) Taiwan, 07 December 2012

Oncology

Key words: Pancreatic cancer, monoclonal antibody, clathrin heavy chain, HIF-1a, angiogenesis

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

1928
Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophages

Larissa Milke, Kathrin Schulz, Andreas Weigert, Weixiao Sha, Tobias Schmid, Bernhard Brüne

Carcinogenesis (Oxford University Press) Germany, 04 December 2012

Oncology

Key words: RNA-binding protein tristetraprolin, macrophages, interleukin-16, granulocyte macrophage-colony

1929
Stem Cell-Like Differentiation Potentials of Endometrial Side Population Cells as Revealed by a Newly Developed In Vivo Endometrial Stem Cell Assay

Kaoru Miyazaki, Tetsuo Maruyama , Hirotaka Masuda, Akiko Yamasaki, Sayaka Uchida, Hideyuki Oda, Hiroshi Uchida, Yasunori Yoshimura

PLoS One (PLOS) Japan, 04 December 2012

Stem Cell Research

Key words: Stem cells, cell differentiation, kidneys, stem cell transplantation, endometrium, flow cytometry, stem cell niche, renal transplantation

Organism: Mouse

Tissue: Kidney

1930
Towards the Automated Detection and Characterization of Osteoclasts in Microscopic Images

Andreas Heindl, Martin Schepelmann, Rupert Ecker, Peter Pietschmann, Isabella Ellinger, Alexander K Seewald, Theresia Thalhammer

Principles of Osteoimmunology (Springer) Austria, 01 December 2012

Medical Image Analysis

Key words: Giant Cell Tumor, Joint Photographic Expert Group, Portable Network Graphic, Biological Expert, Osteoclast Culture

Organism: Human

Cell Line: Osteoclasts

1931
Crypts detection in microscopic images using hierarchical structures

Cristian Smochina, Vasile Manta, Walter Kropatsch

Pattern Recognition Letters (Elsevier) Romania, Austria, 29 November 2012

Pathology

Key words: Crypt segmentation, morphological hierarchy, morphological pyramid, biomedical imaging, pathology, microscopy

Organism: Human

Tissue: Colon

1932
The in Vivo Imaging Platform for Cell Tracking in the Stem Cell-Induced Immune Tolerance to Vascularized Composite Allotransplantation: 1756

CJ Wen, HY Cheng, LY Shih, CF Lin, FC Wei

Transplantation (Wolters Kluwer) China, 27 November 2012

Microscopy

Organism: Rat

Tissue: Whole Organism

Pathological State: Allogeneic Transplantation

1933
Proteinuria triggers renal lymphangiogenesis prior to the development of interstitial fibrosis

Saleh Yazdani , Fariba Poosti, Andrea B Kramer, Katarina Mirković, Arjan J Kwakernaak, Menno Hovingh, Maartje C J Slagman, Klaas A Sjollema, Martin H de Borst, Gerjan Navis, Harry van Goor, Jacob van den Born

PLoS One (PLOS) The Netherlands, 26 November 2012

Nephrology

Key words: Lymph , Proteinuria , Kidneys , Fibrosis , Macrophages , Fibroblasts , Epithelial cells , Collagens

Organism: Rat

Tissue: Kidney

Pathological State: Renal Fibrosis

1934
Epithelial Cell Adhesion Molecule Regulates Tumor Initiation and Tumorigenesis via Activating Reprogramming Factors and Epithelial-Mesenchymal Transition Gene Expression in Colon Cancer

Cheng-Wei Lin, Mei-Yin Liao, Wen-Wei Lin, Yi-Ping Wang, Tung-Yin Lu, Han-Chung Wu

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) Taiwan, 16 November 2012

Oncology

Key words: Cancer Biology, Cancer Stem Cells, Cancer Tumor, Promoter Oncogene, Stem Cells EpCAM, Epithelial-Mesenchymal Transition, Reprogramming Factor Tumor-initiating, Cells Tumorsphere

Organism: Human

Tissue: Colon

Pathological State: Cancer

1935
Photodynamic Control of Bioactivity in a Nanofiber Matrix

Shantanu Sur, John B Matson, Matthew J Webber, Christina J Newcomb, Samuel I Stupp

ACS NANO (ACS Publications) USA, 15 November 2012

Nanomedicine

Key words: Supramolecular nanofibers, cell morphological analysis, nitrobenzyl, projected cell area, photodegradable, RGDS epitope

Organism: Mouse

Cell Line: NIH 3T3 mouse embryonic fibroblasts

1936
Valproic Acid Induces Cutaneous Wound Healing In Vivo and Enhances Keratinocyte Motility

Soung-Hoon Lee, Muhammad Zahoor, Jae-Kwan Hwang, Do Sik Min, Kang-Yell Choi

PLoS One (PLOS) South Korea, 07 November 2012

Dermatology

Key words: Wound healing, keratinocytes, collagens, keratins, ERK signaling cascade, Wnt signaling cascade, immunohistochemical analysis, beta-catenin signaling

Organism: Mouse

Tissue: Skin

Pathological State: Cutaneous wound

1937
SOCS-3 is downregulated in progressive CKD patients and regulates proliferation in human renal proximal tubule cells in a STAT1/3 independent manner

H Neuwirt, IE Eder, M Puhr, M Rudnicki

Laboratory Investigation (Nature) Austria, 29 October 2012

Physiology

Key words: Cell proliferation, Cell signalling, Chronic kidney disease

Organism: Human

Tissue: Kidney

Pathological State: Kidney Disease

1938
Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cells

Ji Hyeon Ju, Yu-Jung Heo, Mi-La Cho, Joo-Yeon Jhun, Jin-Sil Park, Seon-Yeong Lee, Hye-Jwa Oh, Su-Jin Moon, Seung-Ki Kwok, Kyung-Su Park, Sung-Hwan Park, Ho-Youn Kim

Arthritis & Rheumatology (Wiley) South Korea, 27 October 2012

Rheumatology

Key words: STAT-3–mediated regulation, rheumatoid arthritis, CD4+ T cells, synovial fluid

Organism: Human

Pathological State: Rheumatoid Arthritis

Cell Line: PBMCs

1939
Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds

Sungsoo S Lee, Brian J Huang, Stuart R Kaltz, Shantanu Sur, Christina J Newcomb, Stuart R Stock, Ramille N Shah, Samuel I Stupp

Biomaterials (Elsevier) USA, 22 October 2012

Regenerative Medicine

Key words: Peptide amphiphile, heparin, heparan sulfate, BMP-2 (bone morphogenetic protein-2), regenerative medicine, bone regeneration

Organism: Rat

Tissue: Bone

1940
Establishing an allergic eczema model employing recombinant house dust mite allergens Der p 1 and Der p 2 in BALB/c mice

Krisztina Szalai, Tamara Kopp, Anna Lukschal, Caroline Stremnitzer, Julia Wallmann, Philipp Starkl, Luc Vander Elst, Jean-Marie Saint-Remy, Isabella Pali-Schöll, Erika Jensen-Jarolim

Experimental Dermatology (Wiley) Austria, Belgium, 15 October 2012

Dermatology

Key words: Allergic eczema, atopic eczema, Der p1 and Der p 2, house dust mite, protease activity, recombinant allergens

Organism: Mouse

Tissue: Skin

Pathological State: Eczema

1941
PDGFR blockade is a rational and effective therapy for NPM-ALK–driven lymphomas

Daniela Laimer, Helmut Dolznig, Karoline Kollmann, Paul W Vesely, Michaela Schlederer, Olaf Merkel, Ana-Iris Schiefer, Melanie R Hassler, Susi Heider, Lena Amenitsch, Christiane Thallinger, Philipp B Staber, Ingrid Simonitsch-Klupp, Matthias Artaker, Sabine Lagger, Suzanne D Turner, Stefano Pileri, Pier Paolo Piccaluga, Peter Valent, Katia Messana, Indira Landra, Thomas Weichhart, Sylvia Knapp, Medhat Shehata, Maria Todaro, Veronika Sexl, Gerald Höfler, Roberto Piva, Enzo Medico, Bruce A Ruggeri, Mangeng Cheng, Robert Eferl, Gerda Egger, Josef M Penninger, Ulrich Jaeger, Richard Moriggl, Giorgio Inghirami and Lukas Kenner

Nature Medicine (Nature) Austria, USA, UK, Italy, 14 October 2012

Oncology

Key words: Mechanism of action, Non-hodgkin lymphoma, Therapeutics

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

1942
Prospero Homeobox 1 Promotes Epithelial–Mesenchymal Transition in Colon Cancer Cells by Inhibiting E-cadherin via miR-9

Mei-Hsuan Lu, Chao-Cheng Huang, Mei-Ren Pan, Hong-Hwa Chen, Wen-Chun Hung

Clinical Cancer Research (AACR Publications) Taiwan, 08 October 2012

Oncology

Key words: Prospero homeobox 1, matrix metalloproteinase activity, epithelial–mesenchymal transition

Organism: Human

Tissue: Colon

Pathological State: Cancer

1943
Investigation of the Relationship Between Prostate Cancer and MSMB and NCOA4 Genetic Variants and Protein Expression

Liesel M FitzGerald, Xiaotun Zhang, Suzanne Kolb, Erika M Kwon, Ying Ching Liew, Antonio Hurtado-Coll, Beatrice S Knudsen, Elaine A Ostrander, Janet L Stanford

Human Mutation (Wiley) USA, Canada, 04 October 2012

Oncology

Key words: Prostate cancer, MSMB, PSP94, NCOA4

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1944
Hepatology AASLD Abstracts

Hepatology (Wiley) UK, 01 October 2012

Hepathology

1945
γ-secretase inhibitors prevent overgrowth of transplanted neural progenitors derived from human-induced pluripotent stem cells

A Ogura, A Morizane, Y Nakajima, S Miyamoto, and J Takahashi

Stem Cells and Development (Mary Ann Liebert Inc.) Japan, 28 September 2012

Regenerative Medicine

Organism: Mouse

Tissue: Brain

1946
Brief Report: Amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223

Yuan-Tsung Li, Shih-Yao Chen, Chrong-Reen Wang, Ming-Fei Liu, Chi-Chen Lin, I-Ming Jou, Ai-Li Shiau, Chao-Liang Wu

Arthritis & Rheumatology (Wiley) Taiwan, 27 September 2012

Rheumatology

Key words: MicroRNA, MiRNA-223 , rheumatoid arthritis, osteoarthritis, reverse transcriptase–polymerase chain reaction

Organism: Mouse

Tissue: Joint Tissue, Bone

Pathological State: Rheumatoid Arthritis

1947
A global downregulation of microRNAs occurs in human quiescent satellite cells during myogenesis

Merel Koning, Paul MN Werker, Marja JA van Luyn, Guido Krenning, Martin C Harmsen

Differentiation (Elsevier) The Netherlands, 26 September 2012

Developmental Biology

Key words: Satellite cells, Skeletal muscle, Quiescence, MicroRNA, MicroRNA microarray

Organism: Human

Tissue: Muscle

1948
Male Microchimerism in the Human Female Brain

William F N Chan , Cécile Gurnot, Thomas J Montine, Joshua A Sonnen, Katherine A Guthrie, J Lee Nelson

PLoS One (PLOS) USA, 26 September 2012

Neuroscience

Key words: Alzheimer disease, brain diseases, pregnancy, natural history of disease, amygdala, frontal lobe, washington, Y chromosomes

Organism: Mouse

Tissue: Brain

1949
Improved assessment of frozen/thawed mouse spermatozoa using fluorescence microscopy

AK Diercks, HF Bürgers, A Schwab, J Schenkel

Journal of veterinary science (Kamje Press) Germany, 20 September 2012

Reproductive Medicine

Key words: cryopreservation, fluorescence microscopy, genetically modified (GM) mice, membrane integrity, 3Rs

1950
Comparative Secretome Analyses Using a Hollow Fiber Culture System with Label-Free Quantitative Proteomics Indicates the Influence of PARK7 on Cell Proliferation and Migration/Invasion in Lung Adenocarcinoma

Ying-Hua Chang , Shu-Hui Lee, Hua-Chien Chang, Yau-Lin Tseng, Wu-Wei La, Chen-Chung Lia, Yeou-Guang Tsa, and Pao-Chi Liao

Journal of Proteome Research (ACS Publications) Taiwan, 17 September 2012

Oncology

Key words: Hollow fiber culture system, label-free quantitative proteomics, PARK7, cancer metastasis

Organism: Human

Tissue: Lung

Pathological State: Cancer

1951
Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes

Y Dombrowski, M Peric, S Koglin, N Kaymakanov, V Schmezer, M Reinholz, T Ruzicka andJ Schauber

Allergy (Wiley) Germany, 13 September 2012

Allergy Research

Key words: AIM2 inflammasome, allergic reaction, cytosolic DNA, honey bee venom, keratinocytes

Organism: Human

Cell Line: Epidermal keratinocytes

1952
Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis

Doris Maria Hummel, Ursula Thiem, Julia Höbaus, Ildiko Mesteri, Lukas Gober, Caroline Stremnitzer, João Graça, Barbara Obermayer-Pietsch, Enikö Kallay

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, UK, 11 September 2012

Oncology

Key words: Vitamin D, colorectal cancer, dysplasia, chemoprevention, cyp24a1, cyp27b1

Organism: Mouse

Tissue: Colon

1953
Quantitative Immunofluorescence Reveals the Signature of Active B-cell Receptor Signaling in Diffuse Large B-cell Lymphoma

Agata M Bogusz, Richard HG Baxter, Treeve Currie, Papiya Sinha, Aliyah R Sohani, Jeffery L Kutok, Scott J Rodig

Clinical Cancer Research (AACR Publications) USA, 10 September 2012

Oncology

Key words: B-cell receptor, diffuse large B-cell lymphomas, DLBCL pathogenesis

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

1954
Isolation and phenotypic characterisation of stem cells from late stage osteoarthritic mesenchymal tissues

Labusca, Luminita, Zugun-Eloae, Florin, Shaw, Georgina, Botez, Paul, Barry, Frank, Mashayekhi, Kaveh

Current stem cell research and Therapy (Ingentaconnect) Romania, 01 September 2012

Stem Cell Research

Key words: Chondrogenesis, mesenchymal stem cells, osteoarthritis, regenerative medicine.

Organism: Human

Tissue: Bone, Adipose Tissue

Pathological State: Osteoarthritis

1955
The use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer

Zhaohui Wang, Yang Yu, Wenbing Dai, Jingkai Lu, Jingrong Cui, Hounan Wu, Lan Yuan, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang

Biomaterials (Elsevier) China, 30 August 2012

Nanomedicine

Key words: Highly metastatic tumor, targeting, nanomedicine, liposomes, delivery

Organism: Mouse

Tissue: Breast, Xenograft Tumor

Pathological State: Cancer

1956
Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia

NS Prolyl, H Domain

Stroke (AHA Journals) Germany, 28 August 2012

Neuroscience

Key words: HIF-1, hypoxia, neuroprotection, PHD, stroke

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

1957
Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205

Martin Puhr, Julia Hoefer, Georg Schäfer, Holger HH Erb, Su Jung Oh, Helmut Klocker, Isabel Heidegger, Hannes Neuwirt, Zoran Culig

The American Journal of Pathology (Elsevier) China, 11 August 2012

Oncology

Key words: Docetaxel, (miR)-200c, miR-205, E-cadherin, Systemic polychemotherapy

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1958
Quantitative and phenotypic analysis of mesenchymal stromal cell graft survival and recognition by microglia and astrocytes in mouse brain

Nathalie De Vocht,Dan Lin, Jelle Praet, Chloé Hoornaert, Kristien Reekmans, Debbie Le Blon, Jasmijn Daans, Patrick Pauwels, Herman Goossens, Niel Hens, Zwi Berneman, Annemie Van der Linden, Peter Ponsaert

Immunobiology (Elsevier) Belgium, 09 August 2012

Immunology

Key words: Astrocytes, brain, cell transplantation, mesenchymal stromal cell, microglia

Organism: Mouse

Tissue: Brain

1959
A mouse model to identify cooperating signaling pathways in cancer

Monica Musteanu, Leander Blaas, Rainer Zenz, Jasmin Svinka, Thomas Hoffmann, Beatrice Grabner, Daniel Schramek, Hans-Peter Kantner, Mathias Müller, Thomas Kolbe, Thomas Rülicke, Richard Moriggl, Lukas Kenner, Dagmar Stoiber, Josef Martin Penninger, Helmut Popper, Emilio Casanova and Robert Eferl

Nature Methods (Nature) Austria, Spain, 05 August 2012

Oncology

Key words: animal disease models, Cancer genetics, Mouse

Organism: Mouse

Tissue: Lung, Pancreas, Skin

Pathological State: Cancer

1960
Activation of Notch Signaling During Ex Vivo Expansion Maintains Donor Muscle Cell Engraftment

Maura H Parker, Carol Loretz, Ashlee E Tyler, William J Duddy, John K Hall, Bradley B Olwin, Irwin D Bernstein, Rainer Storb, Stephen J Tapscott

Stem Cells (Wiley) USA, 03 August 2012

Stem Cell Research

Key words: Striated muscle, satellite cells, regeneration, primary cell culture, notch ligand, cell transplantation

Organism: Mouse

Tissue: Muscle

1961
Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands

Won Ho Yang, Claudia Nussbaum, Prabhjit K Grewal, Jamey D Marth, Markus Sperandio

Blood (American Society of Hematology) USA, Germany, 02 August 2012

Hematology

Key words: Leukocyte trafficking, ST3Gal subfamily, protein glycosylation

Organism: Mouse

Tissue: Lymphoid Tissue

1962
Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

I-Fang Wang, Bo-Shen Guo, Yu-Chih Liu, Cheng-Chun Wu, Chun-Hung Yang, Kuen-Jer Che-Kun James Shen

PNAS (PNAS) USA, 02 August 2012

Neuroscience

Key words: Protein aggregation, neuronal apoptosis

1963
Chapter 9 - Correlated Light Microscopy and Electron Microscopy

Klaas A Sjollema, Ulrike Schnell, Jeroen Kuipers, Ruby Kalicharan, Ben NG Giepmans

Methods in Cell Biology (Elsevier) The Netherlands, 31 July 2012

Microscopy

Key words: Light microscopy, electron microscopy, correlated microscopy, orientation, probes, high resolution, drawing tube, mosaic microscopy

1964
Abstracts for the International Federation of Placenta Associations Meeting 2012

Placenta (Elsevier) , 25 July 2012

Reproductive Medicine

1965
Vasohibin-2 Expressed in Human Serous Ovarian Adenocarcinoma Accelerates Tumor Growth by Promoting Angiogenesis

Yoshifumi Takahashi, Takahiro Koyanagi, Yasuhiro Suzuki, Yasushi Saga, Naoki Kanomata, Takuya Moriya, Mitsuaki Suzuki, Yasufumi Sato

Molecular Cancer Research (AACR Publications) Japan, 23 July 2012

Oncology

Key words: Vasohibin-1, angiogenesis, ovarian cancer, Angiopoietins

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

1966
The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload

Laura MG Meems, Megan V Cannon, Hasan Mahmud, Adriaan A Voors, Wiek H van Gilst, Herman HW Silljé, Willem PT Ruifrok, Rudolf A de Boer

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) The Netherlands, 15 July 2012

Cardiology

Key words: Fibrosis, heart failure, paricalcitol, remodeling, vitamin D receptor, renin

Organism: Mouse

Tissue: Heart

Pathological State: Cardiac Fibrosis

1967
Tumour‐secreted miR‐9 promotes endothelial cell migration and angiogenesis by activating the JAK‐STAT pathway

Guanglei Zhuang, Xiumin Wu, Zhaoshi Jiang, Ian Kasman, Jenny Yao, Yinghui Guan, Jason Oeh, Zora Modrusan, Carlos Bais, Deepak Sampath, Napoleone Ferrara

EMBO Journal (EMBO press) USA, 06 July 2012

Oncology

Key words: Angiogenesis, Endothelium, JAK‐STAT, MicroRNA, Tumour

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1968
1107 In Vitro Generated Human Dendritic Cells Exposed to a Potent Maturation Melanoma Cell Lines Lysate Show a Tolerogenic-like Phenotype and Functionality When Exposed to Dexamethasone Prior to the Maturation Stimuli

C Falcon-Beas, F Tempio, B Pesce, J Aguillon, C Pereda, C Saffie, F Salazar-Onfray, MN Lopez

European Journal of Cancer (Elsevier) , 06 July 2012

Oncology

1969
1110 Modulation of Genistein- and Resveratrol-induced Apoptosis and Cell Proliferation in Colon Cancer Cells

LI Brasoveanu, D Hotnog, C Hotnog, M Bostan, M Mihaila

European Journal of Cancer (Elsevier) , 06 July 2012

Oncology

1970
1109 Density and Organization of B Cells, Including the Activation-induced Cytidine Deaminase (AID)-positive Sub-population, Within Active Tumor Border of Human Colorectal Cancer Liver Metastases Shows a Positive Association With Survival Prognosis

A Meshcheryakova, M Svoboda, E Bajna, J Maresch, J Jensen-Jarolim, M Bergmann, D Tamandl, D Mechtcheriakova

European Journal of Cancer (Elsevier) , 06 July 2012

Oncology

1971
1108 Histidine-rich Glycoprotein Regulates Macrophage Differentiation

O Noguer, S Tugues, S Honjo, L Claesson-Welsh

European Journal of Cancer (Elsevier) , 06 July 2012

Oncology

1972
A Novel Nucleus-Based Classifier for Discrimination of Osteoclasts and Mesenchymal Precursor Cells in Mouse Bone Marrow Cultures

Andreas Heindl, Alexander K Seewald, Martin Schepelmann, Radu Rogojanu, Giovanna Bises, Theresia Thalhammer, and Isabella Ellinger

International Journal of Medical and Health Sciences (Open Science Index) Austria, 01 July 2012

Osteology

Key words: osteoclasts, machine learning, ellipse fitting.

1973
Pristane-induced lupus as a model of human lupus arthritis: evolvement of autoantibodies, internal organ and joint inflammation

H Leiss, B Niederreiter, T Bandur, B Schwarzecker, S Blüml, G Steiner, W Ulrich3, JS Smolen, GH Stummvoll

Lupus (SAGE Journals) Austria, 01 July 2012

Rheumatology

Key words: Lupus arthritis pristane-induced lupus (PIL), systemic lupus erythematosus (SLE)

Organism: Mouse

Tissue: Joint Tissue, Bone, Lung, Kidney

Pathological State: Arthritis, Lupus

1974
RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas

Maciej Tarnowski, Gabriela Schneider, Gabriele Amann, Geoffrey Clark, Peter Houghton, Frederic G Barr, Lukas Kenner, Mariusz Z Ratajczak, Magda Kucia

International Journal of Oncology (Spandidos Publications) USA, Austria, Poland, 28 June 2012

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

1975
Cisplatin and quantum dots encapsulated in liposomes as multifunctional nanocarriers for theranostic use in brain and skin

Li-Wen Zhang, Chih-Jen Wen, Saleh A Al-Suwayeh, Tzu-Chen Yen, Jia-You Fang

Journal of Nanoparticle Research (Springer) Taiwan, Saudi Arabia, 19 June 2012

Nanomedicine

Key words: Cdse zns qds, cdse zns nanocrystal, nude mouse skin, cdse zns quantum, cisplatin release, mouse skin section, blank liposome, cdse core, skin melanoma, vesicle size, quantum dot, entrapment efficiency, skin uptake, non-treatment group, cisplatin accumulation

Organism: Mouse

Tissue: Brain, Skin

1976
Monitoring neutrophils and platelets during casein-induced anaphylaxis in an experimental BALB/c mouse model

D Krishnamurti, P Starkl, K Szalai, F Roth-Walter, S C Diesner, M Mittlboeck, C Manhalter, E Untersmayr, E Jensen-Jarolim

Clinical and Experimental Allergy (Wiley) Austria, 15 June 2012

Allergy Research

Key words: Mast cells, basophils , alum-adsorbed casein, peripheral neutropenia

1977
Quantitative analysis of binding sites for 9-fluoropropyl-(+)-dihydrotetrabenazine ([18F]AV-133) in a MPTP-lesioned PD mouse model

Ko-Ting Chao, Hsin-Hsin Tsao, Yi-Hsin Weng, Ing-Tsung Hsiao, Chia-Ju Hsieh, Shiaw-Pyng Wey, Tzu-Chen Yen, Mei-Ping Kung,Kun-Ju Lin

Synapse (Wiley) Taiwan, 13 June 2012

Neuroscience

Key words: Positron emission tomography, quantitative autoradiography, immunohistochemistry, vesicular monoamine transporter 2, standardized uptake value

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's Disease

1978
Prognostic role of indoleamine 2,3-dioxygenase in endometrial carcinoma

Renske A de Jong, Ido P Kema, Annemarie Boerma, H Marike Boezen, Johannes JL van der Want, Marloes JM Gooden, Harry Hollema, Hans W Nijman

Gynecologic Oncology (Elsevier) The Netherlands, 02 June 2012

Oncology

Key words: Endometrial carcinoma, indoleamine 2, 3-dioxygenase, T-lymphocytes, prognosis

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

1979
Evidence That Activated Hedgehog Signaling Predicts for Poor Clinical Outcome in Acute Myeloid Leukemia

Veronica Campbell, Eleni Tholouli, M Travis Quigley, John Keilty, Patrick Kelly, Karen McGovern, Margaret Read, Jeffery L Kutok, Richard Byers

Blood (American Society of Hematology) USA, UK, 01 June 2012

Oncology

Key words: Hedgehog (Hh), Acute Myeloid Leukemia (AML), Primary CD34+ myeloid blasts

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

1980
CD256 can be found in antibody-mediated renal allograft rejection tissues

Xu H, He X, Zhao W, Guo H, Shi Q, Zhu Y, Zhang X

Clinical Laboratory (NCBI) China, 01 June 2012

Transplantation Medicine

Key words: Tumor necrosis factor, Systemic lupus erythematosus, Rheumatoid arthritis, antibody-mediated rejection

1981
Type 2 diabetes mellitus is associated with an imbalance in circulating endothelial and smooth muscle progenitor cell numbers

J van Ark, J Moser, C P H Lexis, F Bekkema, I Pop, I C C van der Horst, C J Zeebregts, H van Goor, B H R Wolffenbuttel, J L Hillebrands

Diabetologia (Springer) The Netherlands, 01 June 2012

Endocrinology

Key words: smc marker gene, smc differentiation, epc count, mature smc, angiogenic cell, fibrous cap, cell subset, smc lineage, mature ecs, vascular repair, atherosclerotic plaque, real-time rt-pcr, repair capacity, endothelial differentiation, cell mobilisation

Organism: Human

Pathological State: Diabetes

Cell Line: PBMCs

1982
Clinical significance of the ratio between FOXP3 positive regulatory T cell and interleukin-17 secreting cell in renal allograft biopsies with acute T-cell-mediated rejection

Byung H Chung, Hye J Oh, Shang G Piao, Hyeon S Hwang, In O Sun, Sun R Choi, Hoon S Park, Bum S Choi, Yeong J Choi, Cheol W Park, Yong-SoKim, Mi-La Cho Chul W Yan

Immunology (Wiley) South Korea, 01 June 2012

Immunology

Key words: Acute T-cell-mediated rejection, FOXP3, interleukin-17, regulatory T cell, T helper type 17

Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

1983
Point sur les avancées technologiques en hémocytométrie aux JIB 2011

F Berge , G Maggiore, A Frenkian

IRBM News (Elsevier) France, 01 June 2012

Cytometry

1984
Chemical shift MR imaging methods for the quantification of transcatheter lipiodol delivery to the liver: preclinical feasibility studies in a rodent model

Xiaoming Yin, Yang Guo, Weiguo Li, Eugene Huo, Zhuoli Zhang, Jodi Nicolai, Robert A Kleps, Diego Hernando, Aggelos K Katsaggelos, Reed A Omary, Andrew C Larson

Radiology (Radiological Society of North America) USA, 01 June 2012

Medical Image Analysis

Organism: Rat

Tissue: Liver

1985
96. Jahrestagung der Deutschen Gesellschaft für Pathologie e. V.

Der Pathologe (Springer) Germany, 27 May 2012

Pathology

1986
Neural precursors (NPCs) from adult L967Q mice display early commitment to “in vitro” neuronal differentiation and hyperexcitability

Francesca DiFebo, Daniela Curti, Francesca Botti, Gerardo Biella, Paolo Bigini, Tiziana Mennini, Mauro Toselli

Experimental Neurology (Elsevier) Italy, 22 May 2012

Neuroscience

Key words: Neural stem/progenitor cells (NPCs), motoneuron, neurodegeneration, amyotrophic lateral sclerosis, wobbler mouse, sodium channel, hyperexcitability, patch-clamp

Organism: Mouse

Tissue: Brain

1987
Snapshot spectral imaging using optimized diffractive optical elements

M De Biasio, T Arnold, A Tortschanoff, A Hermerschmidt, R Leitner

Next-Generation Spectroscopic Technologies (SPIE) Austria, Germany, 17 May 2012

Microscopy

Key words: snapshot, CTIS, DOE, optimization

1988
Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

John P Leonard, Ann S LaCasce, Mitchell R Smith, Ariela Noy, Lucian R Chirieac, Scott J Rodig, Jian Q Yu, Shankar Vallabhajosula, Heiko Schoder, Patricia English, Donna S Neuberg, Peter Martin, Michael M Millenson, Scott A Ely, Rachel Courtney, Naveed Shaik, Keith D Wilner, Sophia Randolph, Annick D Van den Abbeele, Selina Y Chen-Kiang, Jeffrey T Yap, Geoffrey I Shapiro

Blood (American Society of Hematology) USA, 17 May 2012

Oncology

Key words: Mantle cell lymphoma, cyclin D1–dependent kinase activity, bortezomib, temsirolimus, lenalidomide

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

1989
RTEL1 contributes to DNA replication and repair and telomere maintenance

Evert-Jan Uringa, Kathleen Lisaingo, Hilda A Pickett, Julie Brind'Amour, Jan-Hendrik Rohde, Alex Zelensky, Jeroen Essers, Peter M Lansdorp

Molecular Biology of The Cell (American Society for Cell Biology) Canada, The Netherlands, Australia, 11 May 2012

Cell Biology

Key words: Telomere maintenance, DNA, mRtel1 , embryonic stem cells

Organism: Mouse

Cell Line: Embryonic stem cell

1990
Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid

Khashayarsha Khazaie, Mojgan Zadeh, Mohammad W Khan, Praveen Bere, Fotini Gounari, Kirsten Dennis, Nichole R Blatner, Jennifer L Owen, Todd R Klaenhammerd, Mansour Mohamadzadeh

PNAS (PNAS) USA, 01 May 2012

Oncology

Key words: Dendritic cells regulatory, T cells anti-inflammatory

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

1991
Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia

LC Wang, CY Huang, HK Wang, MH Wu, KJ Tsai

Journal of Neurotrauma (Mary Ann Liebert Inc.) Taiwan, 25 April 2012

Neuroscience

Key words: in vivo studies, ischemia, middle cerebral artery occlusion, therapeutic approach, stroke

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

1992
Mice lacking epidermal PPARγ exhibit a marked augmentation in photocarcinogenesis associated with increased UVB-induced apoptosis, inflammation and barrier dysfunction

Ravi P Sahu, Sonia C DaSilva, Badri Rashid, Kellie Clay Martel, Danielle Jernigan, Shama R Mehta, Deena R Mohamed, Samin Rezania, Joshua R Bradish, Andrew B Armstrong, Simon Warren, Raymond L Konger

International Journal of Cancer (Wiley) USA, 18 April 2012

Oncology

Key words: Photocarcinogenesis, peroxisome proliferators activated receptor gamma, inflammation, apoptosis, differentiation, nonmelanoma skin cancer

Organism: Mouse

Tissue: Skin

Pathological State: Cancer

1993
Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model

Michelle J Lee, Beryl A Hatton, Elisabeth H Villavicencio, Paritosh C Khanna, Seth D Friedman, Sally Ditzler, Barbara Pullar, Keith Robison, Kerry F White, Chris Tunkey, Michael LeBlanc, Julie Randolph-Habecker, Sue E Knoblaugh, Stacey Hansen, Andrew Richards, Brandon J Wainwright, Karen McGovern, James M Olson

PNAS (PNAS) USA, Australia, 04 April 2012

Oncology

Key words: Sonic Hedgehog (Shh) pathway, medulloblastomas, P-glycoprotein (Pgp)

1994
Injection of Amniotic Fluid Stem Cells Delays Progression of Renal Fibrosis

Sargis Sedrakyan, Stefano Da Sacco, Anna Milanesi, Liron Shiri, Astgik Petrosyan, Radka Varimezova, David Warburton, Kevin V Lemley, Roger E De Filippo, Laura Perin

Journal of The American Society of Nephrology (JASN) USA, 01 April 2012

Nephrology

Key words: Stem cells, renal fibrosis

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Fibrosis

1995
Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma

Nataliya Rohr-Udilova, Wolfgang Sieghart, Robert Eferl, Dagmar Stoiber, Linda Björkhem-Bergman, Lennart C Eriksson, Klaus Stolze6 Hubert Hayden, Bernhard Keppler, Sandra Sagmeister, Bettina Grasl-Kraupp, Rolf Schulte-Hermann Markus Peck-Radosavljevic

Hepatology (Wiley) Austria, Sweden, 27 March 2012

Oncology

Key words: Vascular endothelial growth factor, hepatocellular carcinomas, antioxidative glutathione peroxidases

Organism: Human

Tissue: Liver

Pathological State: Cancer

1996
Requirement of Cellular Prion Protein for Intestinal Barrier Function and Mislocalization in Patients With Inflammatory Bowel Disease

Constance SV Peti, Frédérick Barreau, Laura Besnie, Pierre Gandill, Béatrice Rivea, Danielle Chatea, Maryline Ro, Dominique Berreb, Magali Svrce, Philippe Cardo, Monique Rousse, Caroline Clai, Sophie Thenet

Gastroenterology (Elsevier) France, 22 March 2012

Gastroenterology

Key words: Tight Junction, mouse model, cell–cell adhesion, inflammation

Organism: Human

Cell Line: Caco-2/TC7 enterocytes

1997
Biosafety of Non-Surface Modified Carbon Nanocapsules as a Potential Alternative to Carbon Nanotubes for Drug Delivery Purposes

Alan C L Tang, Gan-Lin Hwang, Shih-Jung Tsai, Min-Yao Chang, Zack C W Tang, Meng-Da Tsai, Chwan-Yao Luo, Allan S Hoffman, Patrick C H Hsieh

PLoS One (PLOS) Taiwan, USA, 22 March 2012

Nanomedicine

Key words: Carbon nanotubes, nanomaterials, drug delivery, toxicity, intravenous injections, cytokines, inflammation, alcohols

Organism: Mouse

1998
Induction of intestinal pro-inflammatory immune responses by lipoteichoic acid

Mojgan Zadeh, Mohammad W Khan, Yong Jun Goh, Kurt Selle, Jennifer L Owen, Todd Klaenhammer, Mansour Mohamadzadeh

Journal of Inflammation (Springer) USA, 16 March 2012

Immunology

Key words: Dendritic cell, dextran sulfate sodium, inflammatory bowel disease, lipoteichoic acid, toll-like receptor 2

Organism: Mouse

Tissue: Colon

Pathological State: Intestinal Inflammation

1999
Comparative oncology: ErbB-1 and ErbB-2 homologues in canine cancer are susceptible to cetuximab and trastuzumab targeting

Josef Singer, Marlene Weichselbaumera, Thomas Stockner, Diana Mechtcheriakova, Yury Sobanov, Erika Bajna, Friedrich Wrba, Reinhard Horvat, Johann G Thalhammer, Michael Willmann, Erika Jensen-Jarolim

Molecular Immunology (Elsevier) Austria, 16 March 2012

Oncology

Key words: Comparative oncology, ErbB-1, ErbB-2, Human, Canine, Breast cancer

Organism: Dog

Tissue: Breast

Pathological State: Cancer

2000
Involvement of the insular cortex in regulating glucocorticoid effects on memory consolidation of inhibitory avoidance training

R Fornari, R Wichmann, E Atucha, T Desprez, E Eggens-Meijer and B Roozendaal

Frontiers in behavioral neuroscience (Frontiers Media S.A.) The Netherlands, Brazil, 15 March 2012

Neuroscience

Organism: Rat

Tissue: Brain

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