Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 1801 - 1810 of 3293
1801
High‐Throughput Screening and Hierarchical Topography‐Mediated Neural Differentiation of Mesenchymal Stem Cells

L Yang, KM Jurczak, L Ge, P van Rijn

Advanced Healthcare Materials (Wiley Online Library) The Netherlands , 04 May 2020

Stem Cell Research

Key words: Anisotropic Topography, Hierarchical Structures, High‐Throughput Screening, Human Mesenchymal Stem Cells, Neural Differentiation

Organism: Human

Cell Line: hMSCs

1802
The Prognostic and Predictive Value of SOX2+ Cell Densities in Patients Treated for Colorectal Cancer

TJ Miller, MJ McCoy, TF Lee-Pullen, CC Anyaegbu, C Hemmings, MK Bulsara, CF Platell

Cancers (MDPI) Australia , 29 April 2020

Oncology

Key words: SOX2, Colorectal Cancer, Chemotherapy, Prognosis, Oxaliplatin, 5-Fluorouracil, Cancer Stem Cell

Organism: Human

Tissue: Colon

Pathological State: Cancer

1803
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research

T Glaser, H Shimojo, DE Ribeiro, P Pereira Lopes Martins, R Pereira Beco, M Kosinski, V Fernandes Arnaud Sampaio, J Corrêa-Velloso, A Oliveira-Giacomelli, C Lameu, AP de Jesus Santos, HD Nóbrega de Souza, YD Teng, R Kageyama, H Ulrich

Molecular Psychiatry (Nature) Japan, Brazil, USA, Poland , 29 April 2020

Cell Biology, Neuroscience

Key words: Cell Biology, Diseases, Molecular Biology, Neuroscience

Organism: Mouse

Cell Line: E14Tg2A cells

1804
Acute Effects of Pulmonary Exposure to Zinc Oxide Nanoparticles on Brain in Vivo 2

HC Chuang, YT Yang, HC Chen, YH Hwang, KY Wu, TF Chen, CL Chen, MK Jhan, TJ Cheng

Aerosol and Air Quality Research (AAQR) Taiwan , 25 April 2020

Nanomedicine

Key words: Autophagy, Central Nervous System, Elevated Plus Maze, Morris Water Maze, Nanoparticle, Ubiquitin.

Organism: Rat

Tissue: Brain

1805
A characteristic expression pattern of core circadian genes in the diurnal tree shrew

PH Luo, YM Shu, RJ Ni, YJ Liu, JN Zhou

Neuroscience (Elsevier) China , 25 April 2020

Neuroscience

Key words: Tree Shrew, Diurnal Animal, Circadian Gene, Brain Rhythm, Peripheral Rhythm

Organism: Tree Shrew

Tissue: Brain

1806
In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique

SC Liao, CY Chen, YH Hsu, CT Li, CC Hsieh, MS Tsai, MY Chan, CH Lee, SH Wang, SK NG, HK Tsou, WY Wu

Surface and Coatings Technology (Elsevier) Taiwan , 21 April 2020

Biomaterials

Key words: HiPIMS, TiN, Acrylamide Crosslinking, BMP2 Attachment, In Vitro And In Vivo Studies

Organism: Mouse

Tissue: Skin

1807
Characterization of CD103+ CD8+ tissue‑resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti‑PD‑1 blockade

L Han, QL Gao, XM Zhou, C Shi, GY Chen, YP Song, YJ Yao, YM Zhao, XY Wen, SL Liu, YM Qi, YF Gao

Cancer Immunology, Immunotherpay (Springer) China , 20 April 2020

Oncology, Immunology

Key words: CD103, Tissue-Resident T Cells, Tumor-Infiltrating Lymphocytes, Esophageal Squamous Cell Carcinoma

Organism: Mouse

Tissue: Skin

Pathological State: Cancer

1808
The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos

ZY Chen, NJ Li, FY Cheng, JF Hsueh, CC Huang, FI Lu, TF Fu, SJ, Yan, YH Lee, YJ Wang

International Journal of Molecular Sciences (MDPI) Taiwan , 20 April 2020

Nanomedicine

Key words: Zebrafish Embryos, Acute Toxicity, Silver Nanoparticles, Chorion Pore Size, Lysosomal Activity, Apoptosis

Organism: Fish

Tissue: Whole Organism

1809
Macrophages and Fibroblasts Differentially Contribute to Tattoo Stability

H Strandt, O Voluzan, T Niedermair, U Ritter, J Thalhamer, B Malissen, A Stoeklinger, S Henri

Dermatology (Karger) France, Germany , 19 April 2020

Dermatology

Key words: Tattoo, Macrophage, Fibroblast, Tattoo Maintenance

Organism: Human

Tissue: Skin

1810
Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit

KH Kim, SJ Lee, J Kim, Y Moon

iScience (Cell Press) South Korea , 18 April 2020

Cell Biology

Key words: CTGF/CCN2, Wnt, Ribosomal Insult, Colorectal Cancer, Tumor Niche

Organism: Human

Cell Line: HCT8 and HCT116 cells

Results 1801 - 1810 of 3293
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