Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Filter publications

Customer Publications (A total of 2600 papers published)

1801
Automated muscle fiber type population analysis with ImageJ of whole rat muscles using rapid myosin heavy chain immunohistochemistry

Konstantin D Bergmeister, Marion Gröger, Martin Aman, Anna Willensdorfer, Krisztina Manzano-Szalai, Stefan Salminger and Oskar C Aszmann

Muscle and Nerve (Wiley) Austria, 13 June 2016

Medical Image Analysis

Key words: Automated muscle fiber analysis, fiber population, ImageJ, muscle fiber type, myosin heavy chain, rat

Organism: Rat

Tissue: Muscle

1802
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Pu-Hyeon Cha, Yong-Hee Cho, Sang-Kyu Lee, JaeHeon Lee, Woo-Jeong Jeong, Byoung-San Moon, Ji-Hye Yun, Jee Sun Yang, Sooho Choi, Juyong Yoon, Hyun-Yi Kim, Mi-Yeon Kim, Saluja Kaduwal, Weontae Lee, Do Sik Min, Hoguen Kim, Gyoonhee Han and Kang-Yell Choi

Nature Chemical Biology (Nature) South Korea, 13 June 2016

Oncology

Key words: Cancer therapy, cell signalling, screening, small molecules

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1803
Clonorchis sinensis omega-class glutathione transferases play major roles in the protection of the reproductive system during maturation and the response to oxidative stress

Jeong-Geun Kim, Chun-Seob Ahn, Seon-Hee Kim, Young-An Bae, Na-Young Kwon, Insug Kang, Hyun-Jong Yang, Woon-Mok Sohn, Yoon Kong

Parasites and Vectors (BioMed Central) South Korea, 13 June 2016

Parasitology

Key words: Clonorchis sinensis, glutathione transferase (GST), omega-class GST, sexual maturation, reproductive system, oxidative stress

Organism: Flatworm

Tissue: Whole Organism

1804
Amniotic Fluid Cells Proliferation in Normal and Down Syndrome Subjects

A Honcea, R Iulian, AG Pavel, I Ion, LE Sima

ARS Medica Tomitana (Sciendo) Romania, 11 June 2016

Reproductive Medicine

Key words: Down syndrome, Trisomy 21, amniotic fluid-derived stem cells, proliferation, cell cycle

Organism: Human

Cell Line: Amniotic fluid derived cells

1805
Epidermal desmoglein 1 expression is reduced in kidney transplant recipients compared to immunocompetent patients

Jodi L Johnson, Paul Hoover, Borko D Jovanovic, Kathleen J Green, John J Friedewald, June K Robinson

Journal of Investigative Dermatology (Elsevier) USA, 11 June 2016

Dermatology

Key words: Calcineurin inhibitor, desmoglein, E-cadherin, epidermal growth factor receptor, histone deacetylase inhibitor, immunocompetent patient, K1/10, Keratin 1 or 10, kidney transplant recipient, mycophenolate mofitil, plakoglobin, squamous cell carcinoma, ultraviolet light

Organism: Human

Tissue: Skin

Pathological State: Cancer

1806
ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Amy M Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V Misharin, FuNien Tsai, G Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E Vaughan, Carla M Cuda and Harris Perlman

Journal of Translational Medicine (BioMed Central) USA, 10 June 2016

Immunology

Key words: Arthritis, cholesterol, inflammation, animal models of human disease

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Atherosclerosis

1807
Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang

Molecular Cancer (Springer) Taiwan, 10 June 2016

Oncology

Key words: Histone deacetylase inhibitor, radiation, triple-negative breast cancer, autophagy

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

1808
Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation

Tobias Bergler, Bettina Jung, Felix Bourier, Louisa Kühne, Miriam C Banas, Petra Rümmele, Simone Wurm, Bernhard Banas

PLoS One (PLOS) Germany, 10 June 2016

Transplantation Medicine

Key words: Macropaghes, T-lymphocytes, calcineriurin, inhibitor, renal transplantation

Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

1809
Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer's Disease

Cheng-Chun Wu, Cheng-Chang Lien, Wen-Hsien Hou, Po-Min Chiang,Kuen-Jer Tsai

Scientific Reports (Nature) Taiwan, 06 June 2016

Neuroscience

Key words: Dementia, neural stem cells, regeneration and repair in the nervous system, stem-cell research

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

1810
Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai, CY Huang, MY Hua, CK Yeh, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 26 May 2016

Neuroscience

Key words: Focused ultrasound, Gene therapy, Blood-brain barrier opening, Microbubbles, GDNF

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's Disease

1811
Functional studies on primary tubular epithelial cells indicate a tumor suppressor role of SETD2 in clear cell renal cell carcinoma

J Li, J Kluiver, J Osinga, H Westers, MB van Werkhoven, Marc A Seelen, Rolf H Sijmons, Ankevan den Berg, Klaas Kok

Neoplasia (Elsevier) The Netherlands, 26 May 2016

Oncology

Key words: Primary Tubular Epithelial Cells, Tumor Suppression, SETD2, Renal Cell Carcinoma

Organism: Human

Pathological State: Cancer

Cell Line: PTECs and HKC8 cells

1812
GBIQ: a non-arbitrary, non-biased method for quantification of fluorescent images

Youichirou Ninomiya, Wei Zhao,Yumiko Saga

Scientific Reports (Nature) Japan, 23 May 2016

Medical Image Analysis

Key words: Image processing, software

Organism: Mouse

Cell Line: MESCs (Mouse Embryonic stem cells)

1813
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

Daniela F Quail, Robert L Bowman, Leila Akkari, Marsha L Quick, Alberto J Schuhmacher, Jason T Huse, Eric C Holland, James C Sutton, Johanna A Joyce

Science (American Association for the Advancement of Science) USA, 20 May 2016

Oncology

Key words: Mouse models, glioblastoma multiforme, macrophage

Organism: Mouse

Tissue: Lymphoid Tissue, Connective Tissue

Pathological State: Cancer

1814
Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice

Li-Fang Wang, Kazunari K Yokoyama, Chih-Lung Lin, Tzu-Yin Chen, Hsiu-Wen Hsiao, Pei-Chi Chiang, Chin Hsu

Scientific Reports (Nature) Taiwan, 20 May 2016

Neuroscience

Key words: Neuronal physiology, reproductive biology

Organism: Mouse

Tissue: Ovaries, Penis, Testis

1815
Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria

Xiaoyan Liang, H William Schnaper, Taiji Matsusaka, Ira Pastan, Steve Ledbetter,Tomoko Hayashida

PLoS One (PLOS) USA, 17 May 2016

Nephrology

Key words: Renal fibrosis

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Fibrosis

1816
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

Niek GJ Leusa, Petra E van der Woudena, Thea van den Boscha, Wouter TR Hooghiemstraa, Maria E Ourailidoua, Loes EM Kistemakerc, Rainer Bischoffb, Reinoud Gosensc, Hidde J Haismaa, Frank J Dekker

Biochemical Pharmacology (Elsevier) The Netherlands, 15 May 2016

Pharmacology

Key words: Lysine acetylation, HDACs, inflammation, NF-κB p65, HDAC inhibitors, lung disease

Organism: Mouse

Tissue: Lung

1817
Exploration of more effective neurorrhaphy in facial nerve reconstruction: A comparison focusing on the difference of neural window size and condition of the neurorrhaphy site

Kentaro Ono, Yuhei Yamamoto, Ryuji Shichinohe, Naoki Murao, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa

Journal of Plastic, Reconstructive and Aesthetic Surgery (Elsevier) Japan, 12 May 2016

Neuroscience

Key words: Nerve reconstruction, Facial palsy, Side to side, End to side, Rat

Organism: Rat

Tissue: Brain

1818
The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth

Harini Nivarthi, Claire Gordziel, Madeleine Themanns, Nina Kramer, Markus Eberl, Björn Rabe, Michaela Schlederer, Stefan Rose-John, Thomas Knösel, Lukas Kenner, Patricia Freund, Fritz Aberger, Xiaonan Han, Robert Kralovics, Helmut Dolznig, Susanne Jennek, Karlheinz Friedrich, and Richard Moriggl

Oncotarget (Impact Journals) Austria, germany, USA, 12 May 2016

Oncology

Key words: STAT1, STAT3, colorectal cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

1819
MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

Marjolein Bijlard, Jenny C de Jonge, Bert Klunder, Anita Nomden, Dick Hoekstra, Wia Baron

PLoS One (PLOS) The Netherlands, 12 May 2016

Neuroscience

Key words: Oligodendrocytes, myelin membrane, rat brain tissue

Organism: Rat

Cell Line: Primary oligodendrocyte, OLN-93, HEPG2 cells

1820
In situ hybridization to detect and localize signature cytokines of T-helper (Th) 1 and Th2 immune responses in chicken tissues

Fana Alem Kidane, Ivana Bilic, Taniya Mitra, Patricia Wernsdorf, Michael Hess, Dieter Liebhart

Veterinary Immunology and Immunopathology (Elsevier) Austria, 12 May 2016

Immunology

Key words: In situ hybridization, RNA probes, ChIFN-γ, ChIL-4, ChIL-13

Organism: Chicken

Tissue: Spleen, Liver

1821
Acidic pH-triggered drug-eluting nanocomposites for magnetic resonance imaging-monitored intra-arterial drug delivery to hepatocellular carcinoma

W Park, J Chen, S Cho, S Park, AC Larson, K Na, DH Kim

Applied Materials and Interfaces (ACS Publications) USA, South Korea, 09 May 2016

Nanomedicine, Oncology

Key words: hepatocellular carcinoma, image-guided therapy, iron oxide nanoparticles, nanocomposite microspheres, pH-responsive materials, sorafenib

Organism: Rat

Tissue: Liver

Pathological State: Cancer

1822
Interleukin-25 is detrimental for recovery after spinal cord injury in mice

Dearbhaile Dooley, Evi Lemmens, Peter Ponsaerts, Sven Hendrix

Journal of Neuroinflammation (Springer) Belgium, 06 May 2016

Neuroscience

Key words: IL-25, type 2 immune response, spinal cord injury, basso mouse scale, locomotor recovery Th1 Th2

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

1823
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition

Neeraj Kapur, Hina Mir, Clarence E Clark III, Uma Krishnamurti, Derrick J Beech, James W Lillard and Shailesh Singh

British Journal of Cancer (Nature) USA, 05 May 2016

Oncology

Key words: Colon cancer, Epithelial–mesenchymal transition, Metastasis, Tumour biomarkers

Organism: Human

Tissue: Colon

Pathological State: Cancer

1824
PPARγ inhibits VSMC proliferation and migration via attenuating oxidative stress through upregulating UCP2

Y Zhou, MJ Zhang, BH Li, L Chen, Y Pi, YW Yin, CY Long, X Wang, MJ Sun, X Chen, CY Gao, JC Li, LL Zhang

PLoS One (PLOS) China, 04 May 2016

Cell Biology

Key words: Oxidative stress, Reactive oxygen species, Carotid arteries, Mitochondria, Antioxidants, MTT assay, Fluorescence microscopy, Growth factors

Organism: Mouse

Tissue: Blood Vessels

1825
Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model

Nina Henke, Nerea Ferreirós, Gerd Geisslinger, Martina G Ding, Silke Essler, Dominik C Fuhrmann, Theresa Geis, Dmitry Namgaladze, Nathalie Dehne, and Bernhard Brüne

Oncotarget (Impact Journals) Germany, 03 May 2016

Oncology

Key words: xenobiotics, CYP1A1, DNA damage, breast cancer, fibrosarcoma

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

1826
449 In situ mapping of innate lymphoid cells in normal and inflamed human skin

M Brüggen, W Bauer, B Reininger, E Clim, C Captarencu, B Meier, PM Brunner, L French, G Stingl

Journal of Investigative Dermatology (Elsevier) Austria, 01 May 2016

Immunology

Key words: Innate lymphoid cells, atopic dermatitis, psoriasis, normal human skin, immunofluorescence

Organism: Human

Tissue: Skin

Pathological State: Dermatitis, Psoriasis

1827
Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model

Stefan Hacker, Rainer Mittermayr, Stefanie Nickl, Thomas Haider, Diana Lebherz-Eichinger, Lucian Beer, Andreas Mitterbauer, Harald Leiss, Matthias Zimmermann, Thomas Schweiger, Claudia Keibl, Helmut Hofbauer, Christian Gabriel, Mariann Pavone-Gyöngyösi, Heinz Redl, Erwin Tschachler, Michael Mildner, Hendrik Jan Ankersmit

Scientific Reports (Nature) Austria, 29 April 2016

Regenerative Medicine

Key words: Drug development, regeneration, translational research, trauma

Organism: Pig

Tissue: Skin

Pathological State: Burn Wound

1828
SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth

David Gius

Cancer Research (AACR Publications) USA, 27 April 2016

Oncology

Key words: Mitochondria, pyruvate kinase, acetylation, mammary tumor cells

Organism: Human

Tissue: Breast

Pathological State: Cancer

1829
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling

Yu-Chih Wang, Cheng-Fang Tsai, Hsiao-Li Chuang, Yi-Chih Chang, Hung-Sheng Chen, Jau-Nan Lee, and Eing-Mei Tsai

Oncotarget (Impact Journals) Taiwan, 26 April 2016

Oncology

Key words: Aryl hydrocarbon receptor, sphingosine kinase 1, sphingosine 1-phosphate, sphingosine-1-phosphate receptor 3, breast cancer stem cells

Organism: Human

Pathological State: Cancer

Cell Line: MCF-7 cells (Breast Cancer Cell line)

1830
Tumor-associated B cells in cutaneous primary melanoma and improved clinical outcome

Kanika Garg, Margarita Maurer, Johannes Griss, Marie-Charlotte Brüggen, Ingrid H Wolf, Christine Wagnera, Niels Willi, Kirsten D Mertz, Stephan N Wagner

Human Pathology (Elsevier) Austria, 20 April 2016

Pathology

Key words: CD20, prognosis, melanoma, tumor microenvironment, tumor-associated B cells (TAB), tumor-infiltrating lymphocytes

Organism: Human

Tissue: Skin

Pathological State: Cancer

1831
Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

Ai-Ho Liao,Ying-Jui Lu, Yi-Chun Lin, Hang-Kang Chen, Huey-Kang Sytwu, Chih-Hung Wang

Theranostics (Ivyspring International Publisher) Taiwan, 11 April 2016

Oncology

Key words: Microbubbles, ultrasound, transdermal drug delivery, minoxidil, chitosan oligosaccharide lactate, hair growth

Organism: Pig, Mouse

Tissue: Skin

1832
Biocompatibility Assessment of a New Biodegradable Vascular Graft via In Vitro Co-culture Approaches and In Vivo Model

Marjan Enayati, Magdalena Eilenberg, Christian Grasl, Peter Riedl, Christoph Kaun, Barbara Messner, Ingrid Walter, Robert Liska, Heinrich Schima, Johann Wojta, Bruno K Podesser, Helga Bergmeister

Annals of Biomedical Engineering (Springer) Austria, 07 April 2016

Regenerative Medicine

Key words: Vascular graft, biocompatibility, biodegradable polyurethane, fibroblast-macrophage co-culture

Organism: Rat

Tissue: Blood Vessels

Pathological State: Organ Transplantation

1833
Dose-escalation study for the targeting of CD44v+cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Kohei Shitara, Toshihiko Doi, Osamu Nagano, Chiyo K Imamura, Takeshi Ozeki, Yuya Ishii, Kenji Tsuchihashi, Shunji Takahashi, Takako E Nakajima, Shuichi Hironaka, Miki Fukutani, Hiromi Hasegawa, Shogo Nomura, Akihiro Sato, Yasuaki Einaga, Takeshi Kuwata, Hideyuki Saya, Atsushi Ohtsu

Gastric Cancer (Springer) Japan, 07 April 2016

Oncology

Key words: Cancer stem cellCD44 variant positiveGastric cancerSulfasalazinexCT

Organism: Human

Tissue: Stomach

Pathological State: Cancer

1834
Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells

Bernd Schöpf, Georg Schäfer, Anja Weber, Heribert Talasz,Iris E Eder, Helmut Klocker, Erich Gnaiger

FEBS Journal (FEBS PRESS) Austria, 06 April 2016

Cell Biology

Key words: electron transfer system, high‐resolution respirometry, mitochondria, oxidative phosphorylation, prostate metabolism

Organism: Human

Tissue: Prostate

1835
Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression.

Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CV, Negroiu Gabriela

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) Romania, 06 April 2016

Oncology

Key words: Antigen processing, caveolin, epithelial-mesenchymal transition (EMT), melanoma, structural model

Organism: Human

Tissue: Skin

Pathological State: Cancer

1836
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Jonas Kloeppera,Lars Riedemanna, Zohreh Amoozgara,1, Giorgio Seanoa, Katharina Suseka, Veronica Yua, Nisha Dalviea, Robin L Amelunga, Meenal Dattaa,Jonathan W Songa,Vasileios Askoxylakisa, Jennie W Taylora,Christine Lu-Emersona,Ana Batistaa,Nathaniel D Kirkpatricka,Keehoon Junga, Matija Snuderla, Alona Muzikanskye, Kay G Stubenrauchf, Oliver Krieterf, Hiroaki Wakimotog, Lei Xu1, Lance L Munna, Dan G Dudaa, Dai Fukumuraa, Tracy T Batchelorc, Rakesh K Jaina,

PNAS (PNAS) USA, 04 April 2016

Oncology

Key words: Anti-angiogenic therapy, tumor microenvironment, anti-tumor immunity, macrophage polarization, microglia reprogramming

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

1837
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma

Hagma H Workel, Fenne L Komdeur, Maartje CA Wouters, Annechien Plat, Harry G Klip, Florine A Eggink, G Bea A Wisman, Henriette JG Arts, Maaike HM Oonk, Marian JE Mourits, Refika Yigit, Marco Versluis, Evelien W Duiker, Harry Hollema, Marco de Bruyn, Hans W Nijman

European Journal of Cancer (Elsevier) The Netherlands, 31 March 2016

Oncology

Key words: Tumour-infiltrating lymphocytes, endometrial cancer, adenocarcinoma, CD103, survival

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

1838
Combining ultrasound and lactobacilli treatment for high-fat-diet-induced obesity in mice

A-H Liao, C-B Jiang, C-C Li, H-C Chuang, J-S Chiang Chiau, W-T Chan, C-Y Yeung, M-L Cheng, H-C Lee

Journal of Animal Physiology and Animal Nutrition (Wiley) Taiwan, 29 March 2016

Physiology

Key words: Actobacilli, ultrasound, high-fat-diet-induced obesity mice, micro-CT, fat deposition

Organism: Mouse

Tissue: Liver, Adipose Tissue

Pathological State: Obesity

1839
Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition

M Kuttke, E Sahin, J Pisoni, S Percig, A Vogel, D Kraemmer, L Hanzl, J S Brunner, H Paar, K Soukup, A Halfmann, A M Dohnal, C W Steiner, S Blüml, J Basilio, B Hochreiter, M Salzmann, B Hoesel, G Lametschwandtner, R Eferl, J A Schmidd and G Schabbauer

OncoImmunology (Taylor and Francis) Austria, 28 March 2016

Immunology

Key words: Colitis-associated colon cancer, myeloid Pi3K, tumor immune-surveillance

Organism: Mouse

Tissue: Xenograft Tumor, Colon

Pathological State: Cancer

1840
Chemotherapy of Colorectal Liver Metastases Induces a Rapid Rise in Intermediate Blood Monocytes which Predicts Treatment Response

Dominic Schauer, Patrick Starlinger, Lejla Alidzanovic, Philipp Zajc, Thomas Maier, Alexandra Feldman, Robin Padickakudy, Elisabeth Buchberger, Vanessa Elleder, Andreas Spittlera, Judith Stift, Lorand Pop, Birgit Gruenberger, Thomas Gruenbergera, Christine Brostjan

OncoImmunology (Taylor and Francis) Austria, 22 March 2016

Immunology

Key words: Chemotherapy, colorectal liver metastase, blood monocytes

Organism: Human

Tissue: Liver

Pathological State: Cancer

1841
A specific area of olfactory cortex involved in stress hormone responses to predator odours

Kunio Kondoh, Zhonghua Lu, Xiaolan Ye, David P Olson, Bradford B Lowell and Linda B Buck

Nature (Nature) USA, 21 March 2016

Neuroscience

Key words: Neural circuits, Olfactory cortex, Sensory processing

Organism: Mouse

Tissue: Brain

1842
MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

Somayyeh Hamzei Taj, Widuri Kho, Adrien Riou, Dirk Wiedermann, Mathias Hoehn

Biomaterials (Elsevier) The Netherlands, 19 March 2016

Neuroscience

Key words: MicroRNA-124, ischemic stroke, immune cell modulation/polarization, neuroprotection, functional improvement, arginase-1

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

1843
Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner

Lexiao Li, Pamela Saliba, Stefan Reischl, Hugo H Marti, Reiner Kunze

Neurobiology of Disease (Elsevier) Germany, 19 March 2016

Neuroscience

Key words: PHD2, HIF, neuron, focal cerebral ischemia, hypoxia, VEGF, angiogenesis

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

1844
Unfractionated bone marrow cells attenuate paraquat-induced glomerular injury and acute renal failure by modulating the inflammatory response

SY Gu, TY Yeh, SY Lin, FC Peng

Scientific Reports (Nature) Taiwan, 18 March 2016

Nephrology

Key words: Acute kidney injury, Bone marrow transplantation

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

1845
High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

S Kapoor, D Rodriguez, K Mitchell, RP Wüthrich

Kidney and Blood Pressure Research (Karger) Switzerland, 17 March 2016

Nephrology

Key words: High resolution diagnostic imaging, Total cyst volume, Polycystic kidney disease, PCK rat, Total kidney volume

Organism: Rat

Tissue: Kidney

Pathological State: Kidney Disease

1846
Efficient generation of smooth muscle cells from adipose-derived stromal cells by 3D mechanical stimulation can substitute the use of growth factors in vascular tissue engineering

Mojtaba Parvizi, Lydia AM Bolhuis-Versteeg, Andrá A Poot, Martin C Harmsen

Biotechnology Journal (Wiley) The Netherlands, 15 March 2016

Regenerative Medicine

Key words: Adipose tissue-derived stromal cells (ASC), poly(1, 3-trimethylene carbonate) (PTMC), smooth muscle cells (SMC), transforming Growth Factor beta 1 (TGF-ß1), vascular tissue engineering

Organism: Human

Cell Line: HUVECs, ASC (Human umbilical vein endothelial cells, Adipose tissue derived stromal cells)

1847
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia

Taizou Hirano, Toshiaki Kikuchi, Naoki Tode, Arif Santoso, Mitsuhiro Yamada, Yoshiya Mitsuhashi, Riyo Komatsu, Takeshi Kawabe, Takeshi Tanimoto, Naoto Ishii, Yuetsu Tanaka, Hidekazu Nishimura, Toshihiro Nukiwa, Akira Watanabe, Masakazu Ichinose

EMBO Molecular Medicine (EMBO press) Japan, 14 March 2016

Pathology

Key words: Bronchioles, glycosylation regeneration, OX40 ligand, viral pneumonia

Organism: Dog

Pathological State: Pneumonia

Cell Line: MDCK cells

1848
Internalization of nanopolymeric tracers does not alter characteristics of placental cells

Paolo Bigini, Elisa R Zanier, Silvia Saragozza, Simona Maciotta, Pietro Romele, Patrizia Bonassi Signoroni, Antonietta Silini, Francesca Pischiutta, Eliana Sammali, Claudia Balducci, Martina B Violatto, Laura Talamini, David Garry, Davide Moscatelli, Raffaele Ferrari, Mario Salmona, Maria Grazia De Simoni, Federico Maggi, Giuseppe Simoni, Francesca Romana Grati, Ornella Parolini

Journal of Cellular and Molecular Medicine (Wiley) Italy, 14 March 2016

Cell Biology

Key words: Cell tracing, nanoparticles, mesenchymal stem/stromal cells, placenta, amnion, chorion, hypoxia, ischaemia

Organism: Human

Tissue: Placenta

1849
In primary Sjögren's syndrome high absolute numbers and proportions of B cells in parotid glands predict responsiveness to rituximab as defined by ESSDAI, but not by SSRI

Konstantina Delli, Erlin A Haacke, Frans GM Kroese, Rodney P Pollard, Stephan Ihrler, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frederik KL Spijkervet

Annals of the Rheumatic Diseases (BMJ Journals) The Netherlands, 09 March 2016

Rheumatology

Key words: Sjogren's syndrome, b cells, parotide glands, rituximab

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's Syndrome

1850
Acquisition of chemoresistance and other malignancy-related features of colorectal cancer cells are incremented by ribosome-inactivating stress

CK Oh, SJ Lee, SH Park, Y Moon

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) South Korea, 09 March 2016

Oncology

Key words: Ribosome-inactivating stress (RIS), Colorectal cancer, Activating transcription factor 3 (ATF3), Macrophage inhibitory cytokine-1 (MIC-1), Chemosensitivity

Organism: Mouse

Tissue: Allograft Tumor, Colon

Pathological State: Cancer

1851
Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach

Anastasia Meshcheryakova, Martin Svoboda, Ammar Tahir, Harald C Köfeler, Alexander Triebl, Felicitas Mungenast, Georg Heinze, Christopher Gerner, Philip Zimmermann, Markus Jaritz, and Diana Mechtcheriakova

Oncotarget (Impact Journals) Austria, Switzerland, 07 March 2016

Oncology

Key words: sphingolipid-related targets, sphingosine 1-phosphate/ceramide rheostat, multigene signature, epithelial to mesenchymal transition, lung cancer

Organism: Human

Pathological State: Cancer

Cell Line: Lung adenocarcinoma epithelial cell line A549

1852
Intrathecal transplantation of embryonic stem cell-derived spinal GABAergic neural precursor cells attenuates neuropathic pain in a spinal cord injury rat model

Insik Hwang, Suk-Chan Hahm Suk-Chan Hahm, Kyung-Ah Choi, Sung-Ho Park, Hyesun Jeong, Ji-Hye Yea, Junesun Kim, PhD, Sunghoi Hong, PhD

Cell Transplantation (SAGE Journals) South Korea, 01 March 2016

Regenerative Medicine

Key words: Spinal cord injury (SCI), Neuropathic pain, Spinal GABAergic neurons, Intrathecal transplantation

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

1853
Platelet-rich plasma influences expansion and paracrine function of adipose-derived stromal cells in a dose-dependent fashion

Willemsen, Joep C N, Spiekman, Maroesjka, Stevens, H P Jeroen, van der Lei, Berend, Harmsen, Martin C

Plastic and Reconstructive Surgery (Ingentaconnect) The Netherlands, 01 March 2016

Regenerative Medicine

Organism: Human

Tissue: Adipose Tissue

1854
Double Linear Gradient Biointerfaces for Determining Two-Parameter Dependent Stem Cell Behavior

Patrick Van Rijn, Philipp Kuhn, Qihui Zhou, Torben Van Der Boon, Aneta Schaap-Oziemlak, Theo Van Kooten

ChemNanoMat (Wiley) The Netherlands, 26 February 2016

Biological Methods

Key words: Biointerfaces, gradients, stem cell, wettability, stiffness

Organism: Human

Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)

1855
Fenretinide: a potential treatment for endometriosis

Mary Ellen Pavone, Saurabh S Malpani, Matthew Dyson, J Julie Kim, Serdar E Bulun

Reproductive Sciences (SAGE Journals) USA, 25 February 2016

Reproductive Medicine

Key words: endometriosis, fenretinide, apoptosis, retinol, retinoid, STRA6, retinoic acid

Organism: Mouse

Tissue: Endometrium

Pathological State: Endometriosis

1856
Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice

Eva Bauer, Michaela Schlederer, Ruth Scheicher, Jaqueline Horvath, Petra Aigner, Ana-Iris Schiefer, Renate Kain, Heinz Regele, Gregor Hoermann, Günter Steiner, Lukas Kenner, Veronika Sexl, Andreas Villunger, Richard Moriggl, and Dagmar Stoiber

Oncotarget (Impact Journals) Austria, 23 February 2016

Oncology

Key words: ETV6/RUNX1, BCL2, glomerulonephritis, lymphoma, autoimmunity, Immunology and Microbiology Section, Immune response, Immunity

Organism: Mouse

Tissue: Kidney

1857
In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection

Xiaonan Zhang, Wei Lu, Ye Zheng, Weixia Wang, Lu Bai, Liang Chen, Yanling Feng, Zhanqing Zhang, and Zhenghong Yuan

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 22 February 2016

Virology

Key words: intrahepatic virological events, chronic hepatitis B virus infection

Organism: Human

Tissue: Liver

Pathological State: Hepatitis B Virus Infection

1858
In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain

Wardit Tigchelaar, Anne Margreet De Jong, Wiek H van Gilst, Rudolf A De Boer, Herman HW Silljé

Inside the Cell (Wiley) The Netherlands, 18 February 2016

Cell Biology

Key words: Cardiomyocyte, cell death, EXOG, hypertrophy, mitochondria

Organism: Rat

Cell Line: NRVC cells ( neonatal rat ventricular cardiomyocytes )

1859
Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies

M Sips, M Krykbaeva, T J Diefenbach, M Ghebremichael, B A Bowman, A-S Dugast, A W Boesch, H Streeck, D S Kwon, M E Ackerman, T J Suscovich, P Brouckaert, T W Schacker and G Alter

Mucosal Immunology (Nature) USA, Belgium, Germany, 17 February 2016

Key words: Cell signalling, HIV infections, Phagocytosis, Vaccines

Pathological State: HIV Infection

1860
Aging has small effects on initial ischemic acute kidney injury development despite changing intrarenal immunologic micromilieu in mice

Hye Ryoun Jang, Ji Hyeon Park, Ghee Young Kwon, Jae Berm Park, Jung Eun Lee, Dae Joong Kim, Yoon-Goo Kim, Sung Joo Kim, Ha Young Oh, Wooseong Huh

American Journal of Physiology (APS Journals) South Korea, 15 February 2016

Physiology

Key words: Aging, ischemic, kidney injury, immunologic, micromilieu

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

1861
The in vitro response of tissue stem cells to irradiation with different LETs

Peter W Nagle, Nynke A Hosper, Emily M Ploeg, Marc-Jan van Goethem, Sytze Brandenburg, Johannes A Langendijk, Roland K Chiu, Robert P Coppes

International Journal of Radiation Oncology (Elsevier) The Netherlands, 12 February 2016

Oncology

Key words: In vitro, tissue stem cells, irradiantion, LETs

Organism: Human

Cell Line: HSG cells (human salivary gland cells)

1862
Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy

Hui-Wen Chiu, Cheng-Hsien Chen, Jen-Ning Chang, Chien-Hsiung Chen, Yung-Ho Hsu

Journal of Molecular Medicine (Springer) Taiwan, 11 February 2016

Regenerative Medicine

Key words: Far-infrared, burn wound healing, autophagy NLRP3 inflammasome

Organism: Rat

Tissue: Skin

Pathological State: Burn Wound

1863
Serum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients

Bettina Schlick, Petra Massoner, Angelika Lueking, Pornpimol Charoentong, Mirjam Blattner, Georg Schaefer, Klaus Marquart, Carmen Theek, Peter Amersdorfer, Dirk Zielinski, Matthias Kirchner, Zlatko Trajanoski, Mark A Rubin, Stefan Müllner, Peter Schulz-Knappe, Helmut Klocker

PLoS One (PLOS) Austria, 10 February 2016

Oncology

Key words: Prostate cancer, autoantibodies, inflammation, prostate gland, inflammatory diseases, microarrays, prostate diseases, radical prostatectomy

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1864
Acquisition of tumorigenic potential and enhancement of angiogenesis in pulmonary stem/progenitor cells through Oct-4 hyperexpression

SY Gu, CC Ho, YK Huang, HW Chen, YC Wang, CY Kuo, SC Teng, WM Fu, PC Yang, CW Wu, FC Peng, TY Ling

Oncotarget (Impact Journals) Taiwan, 09 February 2016

Oncology

Key words: pulmonary stem/progenitor cells, cancer initiating cells, Oct-4, angiogenesis, angiopoietins/Tie2

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1865
MINI ORAL SESSIONS (MINI38.12 Multiplex Immunofluorescence Identifies Differences in Immune Microenvironment and Prognostic Biomarkers between Mesothelioma Subtypes)

Tanguy Seiwert, Stephanie Mcgregor, Chengyi Shu, Igor Feldman, Tong Zi, Zhixiang Zuo, Arun Khattri, Aliya Husain, Hadi Duraid, Wickii T Vigneswaran,Thomas N Krausz, Sriram Sathyanarayanan, Hedy Lee Kindle

Journal of Thoracic Oncology (Elsevier) USA, 05 February 2016

Oncology

Key words: Multiplex immunofluorescence, immmune microenvironment, biomarkers, mesothelioma

Organism: Human

Pathological State: Cancer

1866
Oxytocin promotes functional coupling between paraventricular nucleus and both sympathetic and parasympathetic cardioregulatory nuclei

Jason R Yee, William M Kenkel, Jessie L Frijling, Sonam Dodhia, Kenneth G Onishi, Santiago Tovar, Maha J Saber, Gregory F Lewis, Wensheng Liu, Stephen W Porges C Sue Carter

Hormones and Behavior (Elsevier) USA, 04 February 2016

Endocrinology

Key words: Oxytocin, functional coupling, paraventricular nucleus, cardioregulatory nuclei

Organism: Mouse

Tissue: Brain

1867
Characterizing Villitis of Unknown Etiology and Inflammation in Stillbirth

Hayley Derricott, Rebecca L Jones, Susan L Greenwood, Gauri Batra, Margaret J Evans, Alexander EP Heazell

The American Journal of Pathology (Elsevier) UK, 03 February 2016

Reproductive Medicine

Key words: Villitis, inflammation, stillbirth

Organism: Human

Tissue: Placenta

Pathological State: Villitis 

1868
Prevention of SHIV transmission by topical IFN-β treatment

RS Veazey, HA Pilch-Cooper, TJ Hope, G Alter, AM Carias, M Sips, X Wang, B Rodriguez, SF Sieg, A Reich, P Wilkinson, MJ Cameron and MM Lederman

Mucosal Immunology (Nature) USA, 03 February 2016

Virology

Key words: Drug therapy, HIV infections, Mucosal immunology, Viral transmission

Organism: Monkey

Tissue: Uterus

Pathological State: HIV Infection

1869
Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer

Maartje CA Wouters, Fenne L Komdeur1, Hagma H Workel, Harry G Klip, Annechien Plat, Neeltje M Kooi, G Bea A Wisman, Marian JE Mourits, Henriette JG Arts, Maaike HM Oonk, Refika Yigit, Steven de Jong, Cornelis JM Melief, Harry Hollema, Evelien W Duiker, Toos Daemen, Marco de Bruyn, Hans W Nijman

Clinical Cancer Research (High Wire) The Netherlands, 01 February 2016

Oncology

Key words: T-cell diferentiation, tumor-infiltrating lymphocytes, serous ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

1870
FGF2 inhibits endothelial–mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-ß signaling

Ana C P Correia, Jan-Renier A J Moonen, Marja G L Brinker, Guido Krenning

Journal of Cell Science (The Company of Biologists) The Netherlands, 01 February 2016

Cell Biology

Key words: Endothelial–mesenchymal transition, microRNA-20a-mediated repression, canonical TGF-β signaling

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

1871
Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers

Stefan Koeck, Marit Zwierzina, Julia M Huber, Mario Bitsche, Edith Lorenz, Gabriele Gamerith, Jozsef Dudas, Jens M Kelm, Heinz Zwierzina, Arno Amann

Immunobiology (Elsevier) Austria, Switzerland, 01 February 2016

Immunology

Key words: 3D, biomarker, co-culture, cancer, immune cells, infiltration, subpopulation

Organism: Human

Pathological State: Cancer

Cell Line: A549, Colo699, Calu-6 cells (human non-small-cell lung cancer cell lines)

1872
Injectable extracellular matrix hydrogels as scaffolds for spinal cord injury repair

Dmitry Tukmachev, Serhiy Forostyak, Zuzana Koci, Kristyna Zaviskova, Irena Vackova, Karel Vyborny, Ioanna Sandvig, Axel Sandvig, Christopher J Medberry, Stephen F Badylak, Eva Sykova, and Sarka Kubinova

Tissue Engineering Part A (Mary Ann Liebert Inc.) Czech Republic, Norway, UK, Sweden, USA, 28 January 2016

Regenerative Medicine

Key words: spinal cord injury, hydrogel, extracellular matrix, scaffold, tissue engineering, stem cells

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

1873
Amelioration of Experimental Autoimmune Arthritis Through Targeting of Synovial Fibroblasts by Intraarticular Delivery of MicroRNAs 140-3p and 140-5p

Jia-Shiou Peng, Shih-Yao Chen, Chao-Liang Wu, Hao-Earn Chong, Yun-Chiao Ding, Ai-Li Shiau, Chrong-Reen Wang

Arthritis & Rheumatology (Wiley) Taiwan, 25 January 2016

Rheumatology

Key words: Autoimmune arthritis, synovial fibroblasts, MicroRNAs

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Rheumatoid Arthritis

1874
Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway

Jiemeng Lin-Holderer, Lexiao Li, Daniel Gruneberg, Hugo H Marti, Reiner Kunze

Neuropharmacology (Elsevier) Germany, 19 January 2016

Neuroscience

Key words: Dimethyl fumarate, monomethyl fumarate, fumaric acid esters, Nrf2, HIF, ischemia

Organism: Mouse

Tissue: Brain

1875
Novel technologies and emerging biomarkers for personalized cancer immunotherapy

Jianda Yuan, Priti S Hegde, Raphael Clynes, Periklis G Foukas, Alexandre Harari, Thomas O Kleen, Pia Kvistborg, Cristina Maccalli, Holden T Maecker, David B Page, Harlan Robins, Wenru Song, Edward C Stack, Ena Wang, Theresa L Whiteside, Yingdong Zhao, Heinz Zwierzina, Lisa H Butterfield and Bernard A Fox

Journal for ImmunoTherapy of Cancer (Springer) Qatar, USA, Switzerland, Greece, Germany, The Netherlands, Italy, Austria, 19 January 2016

Oncology

Key words: Immune checkpoint blockade, Cancer immunotherapy, Biomarkers, Task Force, Immune monitoring, Technology, Bioinformatics

Organism: Human

Pathological State: Cancer

1876
Energy landscapes and functions of supramolecular systems

Faifan Tantakitti, Job Boekhoven, Xin Wang, Roman V Kazantsev, Tao Yu, Jiahe Li, Ellen Zhuang, Roya Zandi, Julia H Ortony, Christina J Newcomb, Liam C Palmer, Gajendra S Shekhawat, Monica Olvera de la Cruz, George C Schatz and Samuel I Stupp

Nature Materials (Nature) USA, 18 January 2016

Biological Materials

Key words: Bioinspired materials, Materials science

Organism: Mouse

Cell Line: C2C12 Mouse pre-myoblasts

1877
Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma

Mari Nishio, Naoki Urakawa, Manabu Shigeoka, Nobuhisa Takase, Yumi Ichihara, Noriaki Arai, Yu-ichiro Koma, Hiroshi Yokozaki

Pathology International (Wiley) Japan, 18 January 2016

Pathology

Key words: Esophageal cancer, image analysis, macrophages, tumor microenvironment

Organism: Human

Cell Line: PBMCs (Peripheral blood mononuclear cells )

1878
Towards personalised treatment in primary Sjögren's syndrome: baseline parotid histopathology predicts responsiveness to rituximab treatment

Konstantina Delli, Erlin A Haacke, Frans G M Kroese, Rodney P Pollard, Stephan Ihrler, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frederik K L Spijkervet

Annals of the Rheumatic Diseases (High Wire) The Netherlands, Germany, 15 January 2016

Rheumatology

Key words: Sjögren's syndrome, parotid histopathology, responsiveness to rituximab treatment

Organism: Human

Pathological State: Sjögren's Syndrome

1879
Low birth weight associates with hippocampal gene expression

JP Buschdorf, ML Ong, SX Ong, JL MacIsaac, K Chng, MS Kobor, MJ Meaney, JD Holbrook

Neuroscience (Elsevier) Singapore, Canada, 12 January 2016

Neuroscience

Key words: Low birth weight, hippocampus, DNA methylation, mental disorders, microarray

Organism: Monkey

Tissue: Brain

1880
Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease

Meliana Riwanto, Sarika Kapoor, Daniel Rodriguez, Ilka Edenhofer, Stephan Segerer, Rudolf P Wüthrich

PLoS One (PLOS) Switzerland, 11 January 2016

Nephrology

Key words: Kidneys, glycolysis, renal system, epithelial cells, glucose metabolism, apoptosis, ERK signaling cascade, polycystic kidney disease

Organism: Rat

Tissue: Kidney

Pathological State: Kidney Disease

1881
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer

Leila Akkari, Vasilena Gocheva, Marsha L Quick, Jemila C Kester, Alison K Spencer, Alfred L Garfall, Robert L Bowman, Johanna A Joyce

Genes and Development (CHS Press) USA, Switzerland, 10 January 2016

Oncology

Key words: Cathepsin protease, compensatory mechanism, cancer

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

1882
Toll-Like Receptor 4 Is Essential in the Development of Abdominal Aortic Aneurysm

Chao-Han Lai, Kuan-Chieh Wang, Fang-Tzu Lee, Hung-Wen Tsai, Chih-Yuan Ma, Tsung-Lin Cheng, Bi-Ing Chang, Yu-Jen Yang, Guey-Yueh Shi, Hua-Lin Wu

PLoS One (PLOS) Taiwan, 07 January 2016

Immunology

Key words: Macrophages, immune receptor signaling, aneurysms, inflammation, toll-like receptors, aorta, small interfering RNAs, cytokines

Organism: Mouse

Tissue: Kidney

1883
The single-chain anti-TNF-a antibody DLX105 induces clinical and biomarker responses upon local administration in patients with chronic plaque-type psoriasis

Athanasios Tsianakas, Patrick M Brunner, Kamran Ghoreschi, Claudia Berger, Karin Loser, Martin Röcken, Georg Stingl, Thomas Luger, Thomas Jung

Experimental Dermatology (Wiley) Germany, Austria, Switzerland, 06 January 2016

Dermatology

Key words: Psoriasis, TNF-alpha, TNF-alpha-blocker

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

1884
3, 4-Dihydroxy-L-phenylalanine as a novel covalent linker of extracellular matrix proteins to polyacrylamide hydrogels with a tunable stiffness

Olaf Y Wouters, Diana TA Ploeger, Sander M van Putten, and Ruud A Bank

Tissue Engineering Part C (Mary Ann Liebert Inc.) The Netherlands, 05 January 2016

Regenerative Medicine

Key words: Tissue Enigneering, 3, 4-Dihydroxy-L-Phenylalanine, Linker, Extracellular Matrix, Hydrogel, Stiffness

Organism: Human

Cell Line: Human dermal fetal fibroblasts

1885
T1 Mapping by CMR Imaging : From Histological Validation to Clinical Implication

Andreas A Kammerlander, Beatrice A Marzluf, Caroline Zotter-Tufaro, Stefan Aschaue, Franz Duca, Alina Bachman, Klaus Knechtelsdorfer, Matthias Wiesinger, Stefan Pfaffenberge, Andreas Greiser Irene M Lang, Diana Bonderman, Julia Mascherbauer

JACC: Cardiovascular Imaging (Elsevier) Austria, Germany, 01 January 2016

Cardiology

Key words: CMR imaging, histological validation

Organism: Human

Tissue: Heart

1886
N-octanoyl dopamine attenuates the development of transplant vasculopathy in rat aortic allografts via smooth muscle cell protective mechanisms

J Wedel, MC Hottenrott, M Bulthuis, S Huitema, BA Yard, JK Hillebrands

Transplantation (Wolters Kluwer) The Netherlands, Germany, 01 January 2016

Transplantation Medicine

Key words: N-octanoyl Dopamine, Transplant Vasculopathy, Aortic Allografts, Smooth Muscle Cells, Protective Mechanisms

Organism: Rat

Tissue: Blood Vessels

1887
The anti-inflammatory compound curcumin enhances locomotor and sensory recovery after spinal cord injury in rats by immunomodulation

Lucia Machova Urdzikova, Kristyna Karova, Jiri Ruzicka, Anna Kloudova, Craig Shannon, Jana Dubisova, Raj Murali, Sarka Kubinova, Eva Sykova, Meena Jhanwar-Uniyal and Pavla Jendelova

International Journal of Molecular Sciences (MDPI) Czech Republic, USA, 31 December 2015

Neuroscience

Key words: spinal cord injury, curcumin, inflammation, cytokines, secondary processes, NF-κB

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

1888
Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

Elisabeth Strak, Isabella Ellinger, Christina Balthasar, Matthias Scheinast, Jasmin Schatz, Tamara Szattler, Sonja Bleichert, Leila Saleh, Martin Knöfler, Harald Zeisler, Markus Hengstschläger, Margit Rosner, Hans Salzer, Claudia Gundacker

Toxicology (Elsevier) Austria, 29 December 2015

Toxicology

Key words: Mercury, placenta, amino acid transporters

Organism: Human

Tissue: Placenta

1889
Long-term in vitro expansion of salivary gland stem cells driven by Wnt signals

Martti Maimets, Cecilia Rocchi, Reinier Bron, Sarah Pringle, Jeroen Kuipers, Ben NG Giepmans, Robert GJ Vries, Hans Clevers, Gerald de Haan, Ronald van Os, Robert P Coppes

Stem Cell Reports (Elsevier) The Netherlands, 24 December 2015

Stem Cell Research

Key words: In Vitro Expansion, Salivary Gland, Stem Cells, Wnt

Organism: Mouse

Tissue: Salivary Gland

1890
Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals

Martti Maimets, Cecilia Rocchi, Reinier Bron, Sarah Pringle, Jeroen Kuipers, Ben NG Giepmans, Robert GJ Vries, Hans Clevers, Gerald de Haan, Ronald van Os, Robert P Coppes

Stem Cell Reports (Elsevier) The Netherlands, 24 December 2015

Stem Cell Research

Key words: Stem cells, in vitro expansion, wnt signals

Organism: Human

Tissue: Salivary Gland

1891
Co-culture of placental explants with isolated CD4 and CD8 T cells: a functional model to define the consequences of placental inflammation

Hayley Derricott, Rebecca L Jones, Alexander EP Heazell, Susan L Greenwood

Journal of Biological Methods (Springer) UK, 22 December 2015

Reproductive Medicine

Key words: inflammation, placenta, T lymphocytes, villitis, VUE

Organism: Human

Cell Line: Placental T-cells

1892
Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model

J Zhao, S Siddiqui, S Shang, Y Bian, S Bagchi, Y He, CR Wang

eLife (eLife Sciences Publications) USA, 10 December 2015

Microbiology

Key words: Mycolic acid-specific T cells, Mycobacterium tuberculosis, humanized transgenic mouse model

Organism: Mouse

Tissue: Lung

Pathological State: Tuberculosis

1893
Reproductive periodicity, spawning induction, and larval metamorphosis of the hemichordate acorn worm Ptychodera flava

Ching-Yi Lin, Che-Huang Tung, Jr-Kai Yu, Yi-Hsien Su

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution (Wiley) Taiwan, 10 December 2015

Zoology

Key words: Reproductive periodicity, larval metamorphosis, hemichordate

Organism: Acorn worm

Tissue: Penis

1894
Low Hodgkin/Reed-Sternberg Cell Density Assessed with Automated Image Analysis Is a Poor Prognostic Factor in Classic Hodgkin Lymphoma Patients

Vit Prochazka, Tereza Dyskova, Zuzana Prouzova, Tomas Papajik, Jiri Minarik, Juraj Duras, Jozef Michalka, Alice Sykorova, Peter Mikula, Ludek Raida and Eva Kriegova

Blood (American Society of Hematology) Czech Republic, 03 December 2015

Oncology

Key words: Cell Density, Automated Image Analysis, Prognostic Factor, Hodgkin Lymphoma

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

1895
Quantitative Analysis of Tissue Inflammation and Responses to Treatment in Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome and Review of Literature

Chih-An Chen, Wan-Chen Chung, Yuan-Yow Chiou, Yao-Jong Yang, Yung-Chieh Lin, Hans D Ochs, Dr Chi-Chang Shieh

Journal of Microbiology, Immunology and Infection (Elsevier) Taiwan, USA, 01 December 2015

Immunology, Microbiology

Key words: Immune dysregulation, polyendocrinopathy, enteropathy, X-Linked (IPEX) syndrome, regulatory T cells, T helper 2 cells

Organism: Human

Tissue: Small Intestine

Pathological State: Endocrinopathy, Enteropathy, X-linked syndrome

1896
Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo

TT Huang, HC Lai, YF Ko, DM Ojcius, YW Lan, J Martel, JD Young,

J Cancer Treat Diagnosis (Nature) Taiwan, USA, 26 November 2015

Microbiology

Key words: Drug development, Inflammasome

Organism: Human

Tissue: Lung

Pathological State: Pulmonary Fibrosis, Fungal Infection

1897
Dynamic Trk and G Protein Signalings Regulate Dopaminergic Neurodifferentiation in Human Trophoblast Stem Cells

Eing-Mei Tsai, Yu-Chih Wang, Tony Tung-Yin Lee, Cheng-Fang Tsai, Hung-Sheng Chen, Feng-Jie Lai, Kazunari K Yokoyama, Tsung-Hsun Hsieh, Ruey-Meei Wu, Jau-nan Lee

PLoS One (PLOS) Taiwan, USA, 25 November 2015

Neuroscience

Key words: Neurons, DNA transcription, G-protein signaling, stem cells, genomic signal processing, retinoic acid signaling cascade, retinoid signaling, neuronal differentiation

Organism: Human

Cell Line: hTS cells

1898
Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma

Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Kung-Kai Kuo, Hua-Lin Wu, Chien-Chih Chiu, Eing-Mei Tsa, and Po-Lin Kuo

Journal of Agricultural and Food Chemistry (ACS Publications) Taiwan, 20 November 2015

Oncology

Key words: Phthalate, curcumin, hepatocellular carcinoma, metastasis, side population, cancer stem cells

Organism: Mouse

Tissue: Liver, Lung

1899
Alpha-Actinin 4 Is Associated with Cancer Cell Motility and Is a Potential Biomarker in Non–Small Cell Lung Cancer

MC Wang, YH Chang, CC Wu, YC Tyan, HC Chang, YG Goan, WW Lai, PN Cheng, PC Liao

Journal of Thoracic Oncology (Elsevier) Taiwan, 20 November 2015

Oncology

Key words: ACTN4, non–small-cell lung cancers, CL1-0 and CL1-5 cell lines, siRNA

Organism: Human

Tissue: Lung

Pathological State: Cancer

1900
MiR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis

Varun Nagpal, Rahul Rai, Aaron T Place, Sheila B Murphy, Suresh K Verma, Asish K Ghosh, and Douglas E Vaughan

Circulation (AHA Journals) USA, 19 November 2015

Cardiology

Key words: RNA sequence, fibrosis, angiotensin II, transforming growth factor, miR-125b

Organism: Mouse

Tissue: Heart

Pathological State: Cardiac Fibrosis

1901
IMPS-11 Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Seunggu Han, Gerald Reis, Gary Kohanbash, Shruti Srivastav, Stephen Magill, Annette Molinaro, Michael McDermott, Philip Theodosopoulos, Manish Aghi, Mitchel Berger, Igor Barani, Joanna Phillips, Arie Perry, Hideho Okada

Neuro-Oncology (Oxford University Press) USA, 09 November 2015

Oncology

Key words: meningioma, patient prognosis, impact, molecule, programmed cell death 1 ligand 1

Organism: Human

Tissue: Brain

Pathological State: Cancer

1902
CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow

A Nakamura-Ishizu, K Takubo, H Kobayashi, K Suzuki-Inoue, T Suda

Journal of Experimental Medicine (Rockefeller University Press) Japan, 09 November 2015

Stem Cell Research

Key words: CLEC-2, megakaryocyte, hematopoietic stem cells, bone marrow

Organism: Mouse

Tissue: Bone Marrow

1903
Transdermal drug targeting and functional imaging of tumor blood vessels in the mouse auricle

H Schröder, D Komljenovic, M Hecker, T Korff

The FASEB Journal (FASEB) Germany, 06 November 2015

Oncology

Key words: angiogenesis • blood vessel growth • bortezomib • mouse model • perfusion

Organism: Mouse

Pathological State: Cancer

1904
Melanin pigmentation in rat eyes: in vivo imaging by polarization-sensitive optical coherence tomography and comparison to histology

Bernhard Baumann, Johannes Schirmer, Sabine Rauscher, Stanislava Fialová, Martin Glösmann, Marco Augustin, Michael Pircher, Marion Gröger, Christoph K Hitzenberger

Investigative Ophthalmology & Visual Science (ARVO Journals) Austria, 01 November 2015

Ophthalmology

Key words: Melanin Pigmentation, Eyes, In Vivo Imaging, Polarization-Sensitive Optical Coherence Tomography

Organism: Rat

Tissue: Eye

1905
Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-a Production in Women

Morgane Griesbeck, Susanne Ziegler, Sophie Laffont, Nikaïa Smith, Lise Chauveau, Phillip Tomezsko, Armon Sharei, Georgio Kourjian, Filippos Porichis, Meghan Hart, Christine D Palmer, Michael Sirignano, Claudia Beisel, Heike Hildebrandt, Claire Cénac, Alexandra-Chloé Villani, Thomas J Diefenbach, Sylvie Le Gall, Olivier Schwartz, Jean-Philippe Herbeuval, Brigitte Autran, Jean-Charles Guéry, J Judy Chang, and Marcus Altfeld

The Journal of Immunology (American Association of Immunologists) France, Germany, UK, Australia, 30 October 2015

Immunology

Key words: Plasmacytoid dendridic cell levels, IRF5

Organism: Human, Mouse

Cell Line: PBMCs (Peripheral blood mononuclear cells )

1906
Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury

Shao-Ming Wang, Jung-Yu C Hsu, Chiung-Yuan Ko, Nai-En Chiu, Wai-Ming Kan, Ming-Derg Lai, Ju-Ming Wang

Molecular Neurobiology (Springer) Taiwan, 28 October 2015

Neuroscience

Key words: Astrogliosis C/EBPd, MMP-3 RhoA, astrocyte migration

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

1907
Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy

Nastasia Wilfinger, Shane Austin, Barbara Scheiber-Mojdehkar, Walter Berger, Siegfried Reipert, Monika Praschberger, Jakob Paur, Robert Trondl, Bernhard K Keppler, Christoph C Zielinski, and Karin Nowikovsky

Oncotarget (Impact Journals) Austria, 26 October 2015

Oncology

Key words: cancer, p53, BNIP3L, mitophagy, gallium complex

Organism: Human

Pathological State: Cancer

Cell Line: Human colon carcinoma cells

1908
Quantitative Image Analysis of Epithelial and Stromal Area in Histological Sections of Colorectal Cancer: An Emerging Diagnostic Tool.

R Rogojanu, T Thalhammer, U Thiem, A Heindl, I Mesteri, A Seewald, W Jäger, C Smochina, I Ellinger, G Bises

Biomed Research International (Hindawi Publishing Corporation) Austria, Romania, 22 October 2015

Oncology

Key words: Image analysis, histology, colorectal cancer, diagnosis tool

Organism: Human

Tissue: Colon

Pathological State: Cancer

1909
Glucose-regulated protein 94 mediates cancer progression via AKT and eNOS in hepatocellular carcinoma

Chien-Yu Huang, Uyanga Batzorig, Wan-Li Cheng, Ming-Te Huang, Wei- Yu Chen, Po-Li Wei, Yu-Jia Chang

Tumor Biology (Springer) Taiwan, Mongolia, 22 October 2015

Oncology

Key words: GRP94 HCC eNOS AKT Proliferation

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1910
Redox Regulation of Pro-IL-1β Processing May Contribute to the Increased Severity of Serum-Induced Arthritis in NOX2-Deficient Mice

Ya-Fang Huang, Pei-Chi Lo, Chia-Liang Yen, Peter Andrija Nigrovic, Wen-Chen Chao, Wei-Zhi Wang, George Chengkang Hsu, Yau-Sheng Tsai, and Chi-Chang Shieh

Antioxidants and Redox Signaling (Mary Ann Liebert Inc.) Taiwan, USA, 21 October 2015

Rheumatology

Key words: Redox Regulation, Pro-IL-1β, Serum-Induced Arthritis, NOX2

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Rheumatoid Arthritis

1911
An Emerging Approach for Parallel Quantification of Intracellular Protozoan Parasites and Host Cell Characterization Using TissueFAXS Cytometry

Maximilian Schmid, Bianca Dufner, Julius Dürk, Konstanze Bedal, Kristina Stricker, Lukas Ali Prokoph, Christoph Koch, Anja K Wege, Henner Zirpel, Ger van Zandbergen, Rupert Ecker, Bogdan Boghiu, Uwe Ritter

PLoS One (PLOS) Germany, Austria, 21 October 2015

Parasitology

Key words: Macrophages, parasitic diseases, host cells, leishmania major, DAPI staining, cell staining, host-pathogen interactions, intracellular pathogens

Organism: Mouse

Pathological State: Leishmaniasis

Cell Line: Makrophages

1912
The Role of Lysophosphatidic Acid on Airway Epithelial Cell Denudation in a Murine Heterotopic Tracheal Transplant Model

Yukiko Tando, Chiharu Ota, Mitsuhiro Yamada, Satoshi Kamata, Mutsuo Yamaya, Kuniyuki Kano, Shinichi Okudaira, Junken Aoki, and Hiroshi Kubo,

Transplantation (Wolters Kluwer) Japan, 19 October 2015

Transplantation Medicine

Key words: Lysophosphatidic Acid, Airway Epithelial Cells, Denudation, Murine Heterotopic Tracheal Transplant Model

Organism: Mouse

Cell Line: BEAS-2B cells

1913
Development of recombinant collagen-peptide-based vehicles for delivery of adipose-derived stromal cells (ADSC)

M Parvizi, JA Plantinga, C van Spreuwel-Goossens, S van Dongen, S G Kluijtmans, MC Harmsen

Journal of Biomedical Materials Research (Wiley) The Netherlands, 14 October 2015

Biological Materials

Key words: Recombinant-Collagen Microspheres, integrin binding motives, crosslinked, ADSC, delivery

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

1914
Cardioprotective Actions of TGFßRI Inhibition Through Stimulating Autocrine/Paracrine of Survivin and Inhibiting Wnt in Cardiac Progenitors

Yu-Sian Ho, Wan-Hsuan Tsai, Fen-Chiung Lin, Wei-Pang Huang, Lung-Chun Lin, Sean M Wu, Yu-Ru Liu, Wen-Pin Chen

Stem Cells (Wiley) Taiwan, USA, 10 October 2015

Stem Cell Research

Key words: Nkx2.5, sca1, Birc5, survivin, MEK/ERK, Wnt3a

Organism: Mouse

Tissue: Heart

Pathological State: Cardiac Fibrosis

1915
YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts

Bram Piersma, Saskia de Rond, Paul MN Werker, Stellar Boo, Boris Hinz, Marike M van Beuge, Ruud A Bank

The American Journal of Pathology (Elsevier) The Netherlands, Canada, 10 October 2015

Pathology

Key words: Myofibroblast, fibroblasts, YAP 1

Organism: Human

Pathological State: Dupuytren's Disease

Cell Line: Dermal fibroblasts

1916
The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis

Masum M Mia, Ruud A Bank

Cell and Tissue Research (Springer) The Netherlands, 09 October 2015

Cell Biology

Key words: Fibrosis, collagen, myofibroblasts, caffeic acid, lysyl hydroxylase

Organism: Human

Cell Line: HDFa and HLFa Fibroblasts

1917
Characterization of sulfur mustard resistant keratinocyte cell line HaCaT/SM

Wolf Markus, Siegert Markus, Rothmiller Simone, Scheithauer Nina, Strobelt Romano, Steinritz Dirk, Thiermann Horst, Schmidt Annette

Toxicology Letters (Elsevier) Germany, 09 October 2015

Toxicology

Key words: Sulfur mustard, resistance, keratinocytes

Organism: Human

Cell Line: HaCaTs (human keratinocyte cell line )

1918
YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model

Tsion Zewdu Minas, Jenny Han, Tahereh Javaheri, Sung-Hyeok Hong, Michaela Schlederer, Yasemin Saygideğer-Kont, Haydar Çelik, Kristina M Mueller, Idil Temel, Metin Özdemirli, Heinrich Kovar, Hayriye Verda Erkizan, Jeffrey Toretsky, Lukas Kenner, Richard Moriggl,and Aykut Üren

Oncotarget (Impact Journals) USA, Austria, 08 October 2015

Oncology

Key words: EWS-FLI1, ETS fusion proteins, YK-4-279, ewing sarcoma, erythoid leukemia

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1919
Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury

Yuan-Yu Hsueh, Ya-Ju Chang, Chia-Wei Huang, Fitri Handayani, Yi-Lun Chiang, Shih-Chen Fan, Chien-Jung Ho, Yu-Min Kuo, Shang-Hsun Yang, Yuh-Ling Chen, Sheng-Che Lin, Chao-Ching Huang and Chia-Ching Wu

Scientific Reports (Nature) Taiwan, 08 October 2015

Neuroscience

Key words: Neural progenitors, stem cells, brain injury

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

1920
Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis

Dominique Muschter, Nicole Schäfer, Hubert Stangl, Rainer H Straub, Susanne Grässel

PLoS One (PLOS) Germany, 02 October 2015

Rheumatology

Key words: Osteoclasts, neurotransmitters, arthritis, macrophages, apoptosis, gene expression, adenylyl cyclase, immune receptors

Organism: Human

Pathological State: Cancer

Cell Line: SAOS2 cells (primary osteogenic sarcoma cells)

1921
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis

Eva Hainzl, Silvia Stockinger, Isabella Rauch, Susanne Heider, David Berry, Caroline Lassni, Clarissa Schwab, Felix Rosebrock, Gabriel Milinovich, Michaela Schlederer, Michael Wagner, Christa Schleper, Alexander Loy, Tim Urich, Lukas Kenner, Xiaonan Han, Thomas Decker, Birgit Strobl, Mathias Müller

The Journal of Immunology (American Association of Immunologists) Austria, USA, 02 October 2015

Gastroenterology

Key words: Intestinal epithelial cell, acute colitis

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

1922
The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence

Monika Maleszewska, Byambasuren Vanchin, Martin C Harmsen, Guido Krenning

Angiogenesis (Springer) The Netherlands, Germany, 28 September 2015

Cell Biology

Key words: Endothelial cell, enhancer of zeste homolog-2 (EZH2), fluid shear stress (FSS), mechanotransduction, chromatin

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

1923
Putative Prostate Cancer Risk SNP in an AR Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in AR Target Sites

Huajie Bu, Narisu Narisu, Bettina Schlick, Johannes Rainer, Thomas Manke, Georg Schäfer, Lorenza Pasqualini, Peter Chines, Michal R Schweiger, Christian Fuchsberger, Helmut Klocker

Human Mutation (Wiley) Austria, Germany, Italy, USA, 28 September 2015

Oncology

Key words: Prostate cancer, risk SNPs, androgen receptor, melanophilin, MLPH, androgen regulation, AR

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1924
A sunblock based on bioadhesive nanoparticles

Y Deng, A Ediriwickrema, F Yang, J Lewis, M Girardi, WM Saltzman

Nature Materials (Nature) USA, 28 September 2015

Nanomedicine

Key words: Biomedical engineering, Drug delivery

Organism: Mouse

Tissue: Skin

1925
Amelioration of Chemotherapy-Induced Intestinal Mucositis by Orally Administered Probiotics in a Mouse Model

Chun-Yan Yeung, Wai-Tao Chan, Chun-Bin Jiang, Mei-Lien Cheng, Chia-Yuan Liu, Szu-Wen Chang, Jen-Shiu Chiang Chiau, Hung-Chang Lee

PLoS One (PLOS) Taiwan, 25 September 2015

Oncology

Key words: Probiotics, gastrointestinal tract, diarrhea, mouse models, cytokines, jejunum, lactobacillus, cancer treatment

Organism: Mouse

Tissue: Small Intestine

Pathological State: Intestinal Mucositis

1926
The great escape: Pseudomonas breaks out of the lung

A Zhang, SM Rangel, AR Hauser

Microbial Cell (NCBI) USA, 23 September 2015

Microbiology

Key words: Pseudomonas aeruginosa, ExoS, pneumonia, dissemination

Organism: Mouse

Tissue: Lung

Pathological State: Plasmodium Infection

1927
Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage

Patricia Aparicio-Domingo, Monica Romera-Hernandez, Julien J Karrich, Ferry Cornelissen, Natalie Papazian, Dicky J Lindenbergh-Kortleve, James A Butler, Louis Boon, Mark C Coles, Janneke N Samsom, Tom Cupedo

Journal of Experimental Medicine (Rockefeller University Press) The Netherlands, UK, 21 September 2015

Stem Cell Research

Key words: Type 3 innate lymphoid cells, intestinal epithelial stem cells, tissue damage

Organism: Mouse

Tissue: Small Intestine, Colon

1928
Bone marrow micro-environmental CD4+ and CD8+ lymphocyte infiltration patterns define overall- and progression free survival in standard risk Multiple Myeloma – an analysis from the Austrian Myeloma Registry

Wolfgang Willenbacher, Ella Willenbacher, Claudia Zelle-Rieser, Rainer Biedermann, Roman Weger, Karin Jöhrer, Andrea Brunner

Leukemia and Lymphoma (Taylor and Francis) Austria, 19 September 2015

Oncology

Key words: Bone marrow, lymphocite infiltration, myeloma

Organism: Human

Tissue: Bone

Pathological State: Cancer

1929
Quantitative functional MRI in a clinical orthotopic model of pancreatic cancer in immunocompetent Lewis rats

Zhuoli Zhang, Linfeng Zheng, Weiguo Li, Andrew C Gordon, Yi Huan, Junjie Shangguan, Daniel Procissi, David J Bentrem, Andrew C Larson

American Journal of Translational Research (e-Century Publishing Corporation) USA, China, 15 September 2015

Oncology

Key words: Magnetic resonance imaging, imaging biomarker, pancreatic cancer, immunocompetent Lewis rats

Organism: Rat

Tissue: Pancreas

Pathological State: Cancer

1930
Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer

CJ Yang, YP Liu, HY Dai, YL Shiue, CJ Tsai, MS Huang, YT Yeh

Oncotarget (Impact Journals) Taiwan, 15 September 2015

Oncology

Key words: HDAC6, NF-κB, MMP2, metastasis, lung cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

1931
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences

Aswin Mangerich, Malgorzata Debiak, Matthias Birtel, Viviane Ponath, Frank Balszuweit, Kirsten Lex, Rita Martello, Waltraud Burckhardt-Boer, Romano Strobelt, Markus Siegert, Horst Thiermanb, Dirk Steinritz, Annette Schmidt, Alexander Bürkle

Toxicology Letters (Elsevier) Germany, 14 September 2015

Toxicology

Key words: Poly(ADP-ribose), PARP inhibitors, sulfur mustard, nitrogen mustard, genotoxicity, HaCaT, mass spectrometry, micronucleus

Organism: Human

Cell Line: HaCaTs (human keratinocyte cell line )

1932
Efficient therapy of ischaemic lesions with VEGF121-fibrin in an animal model of systemic sclerosis.

Allipour Birgani S, Mailänder M, Wasle I, Dietrich H, Gruber J, Distler O, Sgonc R

Annals of the Rheumatic Diseases (BMJ Journals) Austria, Switzerland, 11 September 2015

Rheumatology

Key words: Outcomes research, systemic sclerosis, treatment

Organism: Chicken

Tissue: Skin

Pathological State: Systemic Sclerosis

1933
The ß-catenin signaling pathway induces aggressive potential in breast cancer by up-regulating the chemokine CCL5

Rika Yasuhara, Tarou Irié, Kenya Suzuki, Terumasa Sawada, Noriko Miwa, Akiko Sasaki, Yuko Tsunoda, Seigo Nakamura, Kenji Mishima

Experimental Cell Research (Elsevier) Japan, 10 September 2015

Oncology

Key words: ß-Catenin, metastasis, breast cancer, cytokines, CCL5

Organism: Human

Tissue: Breast

Pathological State: Cancer

1934
Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling

S Kaduwal, WJ Jeong, JC Park, KH Lee, YM Lee, SH Jeon, YB Lim, DS Min, KY Choi

Oncotarget (Impact Journals) South Korea, 05 September 2015

Oncology

Key words: Sur8, Ras, PI3K, cell migration, metastasis

Organism: Human

Tissue: Skin

Pathological State: Cancer

1935
The IκB kinase inhibitor ACHP strongly attenuates TGF β1‐induced myofibroblast formation and collagen synthesis

Masum M Mia, Ruud A Bank

Journal of Cellular and Molecular Medicine (Wiley) The Netherlands, 04 September 2015

Cell Biology

Key words: Fibrosis, collagen, myofibroblasts, fibronectin, lysyl hydroxylase

Organism: Human

Cell Line: HDFa and HLFa Fibroblasts

1936
Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

Christoph Geisenberger, Andreas Mock, Rolf Warta,Carmen Rapp, Christian Schwager, Andrey Korshunov, Ann-Katrin Nied, David Capper, Benedikt Brors, Christine Jungk, David Jones, V Peter Collins, Koichi Ichimura, L Magnus Bäcklund, Elena Schnabel, Michel Mittelbron, Bernd Lahrmann, Siyuan Zheng, Roel G W Verhaak, Niels Grabe, Stefan M Pfister, Christian Hartmann, Andreas von Deimling, Jürgen Debus, Andreas Unterberg, Amir Abdollahi, Christel Herold-Mende

Acta Neuropathologica (Springer) Germany, UK, Japan, Sweden, USA, 01 September 2015

Pathology

Key words: Glioblastoma, molecular profiling, microglia, long-term survival, short-term survival

Organism: Human

Tissue: Brain

Pathological State: Cancer

1937
Increased complexity in carcinomas: analyzing and modeling the interaction of human cancer cells with their microenvironment

Mira Stadler, Stefanie Walter, Angelika Walzl, Nina Kramer, Christine Unger, Martin Scherze, Daniela Unterleuthner, Markus Hengstschläger, Georg Krupitza, Helmut Dolznig

Seminars in Cancer Biology (Elsevier) Austria, 28 August 2015

Oncology

Key words: Carcinoma, human cancer cells, microenvironment

1938
SPIO-labeled yttrium microspheres for MR imaging quantification of transcatheter intrahepatic delivery in a rodent model

W Li, Z Zhang, AC Gordon, J Chen, J Nicolai, RJ Lewandowski, RA Omary, AC Larson

Radiology (Radiological Society of North America) USA, 27 August 2015

Medical Imaging

Organism: Rat

Tissue: Liver

1939
Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response

Dong Hoon Kang, Mina Choi, Soyoung Chang, Min Young Lee, Doo Jae Lee, Kyungsun Choi, Junseong Park, Eun Chun Han, Daehee Hwang, Kihwan Kwon, Hanjoong Jo, Chulhee Choi, Sang Won Kang

PLoS One (PLOS) South Korea, 25 August 2015

Cell Biology

Key words: Carotid arteries, small interfering RNAs, transfection, proteomics, membrane proteins, immunohistochemistry techniques, protein interaction networks, network analysis

Organism: Human

Tissue: Blood Vessels

1940
Acceleration of atherogenesis in ApoE−/− mice exposed to acute or low-dose-rate ionizing radiation

Mariateresa Mancuso, Emanuela Pasquali, Ignacia Braga-Tanaka, Satoshi Tanaka, Alessandro Pannicelli, Paola Giardullo, Simonetta Pazzaglia, Soile Tapio, Michael J Atkinson, Anna Saran

Oncotarget (Impact Journals) Italy, Japan, Germany, 22 August 2015

Oncology

Key words: Atherosclerosis, ApoE mice, radiation, aorta

Organism: Mouse

Tissue: Heart, Blood Vessels

1941
Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model

M Butinar, M T Prebanda, J Rajkovic, B Jeric, V Stoka, C Peters, T Reinheckel, A Krüger, V Turk, B Turk and O Vasiljeva

Oncogene (Nature) Slovenia, Germany, USA, 19 August 2015

Oncology

Key words: Tumor cells, oxidative stress, breast cancer

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

1942
Differential Utilization of Dietary Fatty Acids in Benign and Malignant Cells of the Prostate

Andrea Dueregger, Bernd Schöpf, Theresa Eder, Julia Höfer, Erich Gnaiger, Astrid Aufinger, Lukas Kenner, Bernhard Perktold, Reinhold Ramoner, Helmut Klocker, Iris E Eder

PLoS One (PLOS) Austria, 18 August 2015

Oncology

Key words: Prostate gland, mitochondria, glucose, glucose metabolism, mitochondrial DNA, fatty acids, cell metabolism, prostate cancer

Organism: Human

Pathological State: Cancer

Cell Line: Prostate Cancer cells

1943
Impact of CYP24A1 overexpression on growth of colorectal tumour xenografts in mice fed with vitamin D and soy

Julia Höbaus, Samawansha Tennakoon, Petra Heffeter, Charlotte Groesche, Abhishek Aggarwal, Doris M Hummel, Ursula Thiem, Rodrig Marculescu, Walter Berger, Enikö Kállay

International Journal of Cancer (Wiley) Austria, 17 August 2015

Oncology

Key words: Colon cancer, vitamin D, CYP24A1, soy, xenograft

Organism: Human

Pathological State: Cancer

Cell Line: HT29 cells (colon cancer cell line)

1944
Interleukin 2 Topical Cream for Treatment of Diabetic Foot Ulcer: Experiment Protocol

SWS Chan

JMIR Research Protocols (JMIR Publications) USA, 14 August 2015

Dermatology

Key words: type 1 diabetes, topical cream, chronic wound healing, immunotherapy, IL-2

Organism: Mouse

Tissue: Skin

Pathological State: Diabetes

1945
An Echinococcus multilocularis antigen B3 proteoform that shows specific antibody responses against active stage alveolar echinococcosis

CS Ahn, H Cai, JG Kim, X Han, X Ma, YA Bae, HJ Yang, I Kang, H Wang, Y Kong

Journal of Clinical Microbiology (American Society for Microbiology) China, South Korea, 12 August 2015

Microbiology

Key words: Echinococcus multilocularis, Antigen B3, Antibody Response, Alveolar Echinococcosis

Organism: Human, Mouse

Pathological State: Echinococcus Infection

1946
Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model

Young-Bin Chen, Ying-Wei Lan, Lih-Geeng Chen, Tsung-Teng Huang, Kong-Bung Choo, Winston T K Cheng, Hsuan-Shu Lee, Kowit-Yu Chong

Cell Stress and Chaperones (Springer) China, 05 August 2015

Cell Biology

Key words: Stem cell-based gene therapy, resveratrol Hsp70 promoter VEGFA, mouse model, emphysema

Organism: Mouse

Tissue: Lung

1947
Abstract 1091: A new image processing approach for functional context-based analysis of tryptase positive mast cells in cutaneous T-cell lymphomas

Radu Rogojanu, Johanna Eder, Waltraud Jerey, Gabriele Klosner, Verene Paulitschke, Isabella Ellinger, Theresia Thalhammer, Dan Kolmer, Franz Trautinger

Cancer Research (AACR Publications) Austria, 01 August 2015

Oncology

Key words: Image processing, tryptase positive mast cells, cutaneous, T-cell lymphoma

Organism: Human

Tissue: Skin

Pathological State: Cancer

1948
Abstract 1292: Validation study on quantitative analysis method of interrelationships between immune cells and prostate epithelial and cancer cells

Gero Kramer, Lukas Kenner, Thomas Szekeres, Shahrokh Shariat, Sarah Schwarz

Cancer Research (AACR Publications) Austria, 01 August 2015

Oncology

Key words: Quantitative analysis, immune cells, prostate epithelial, cancer cells

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1949
Early inflammatory responses following cell grafting in the CNS trigger activation of the subventricular zone: a proposed model of sequential cellular events

Praet J, Santermans E, Daans J, Le Blon D, Hoornaert C, Goossens H, Hens N, Van der Linden A, Berneman Z, Ponsaerts P

Cell Transplantation (SAGE Journals) Belgium, 01 August 2015

Neuroscience

Key words: Cell transplantation, Graft apoptosis, Immune response, Angiogenesis, Cell proliferation

Organism: Mouse

Tissue: Brain

1950
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B

Pablo Muñoz-Llancao, Daniel R Henríquez, Carlos Wilson, Felipe Bodaleo, Erik W Boddeke, Frank Lezoualc'h, Martina Schmidt, Christian González-Billault

Journal of Neuroscience (Society for Neuroscience) The Netherlands, Chile, France, 01 August 2015

Neuroscience

Key words: Exchange protein, cAMP, neuronal polarization, Rap1B

Organism: Rat

Cell Line: Hippocampal neurons 

1951
Significant Therapeutic Efficacy with Combined Radioimmunotherapy and Cetuximab in Preclinical Models of Colorectal Cancer

Vessela Vassileva, Vineeth Rajkumar, Mario Mazzantini, Mathew Robson, Adam Badar, Surinder Sharma, Erik Årstad, Daniel Hochhauser, Mark F Lythgoe, Geoffrey M Boxer, Rosmund Barbara Pedley

The Journal of Nuclear Medicine (SNMMI) UK, 01 August 2015

Oncology

Key words: Radioimmunotherapy, cetuximab, colorectal cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1952
Outcome in Heart Failure with Preserved Ejection Fraction: The Role of Myocardial Structure and Right Ventricular Performance

Georg Goliasch, Caroline Zotter-Tufaro, Stefan Aschauer, Franz Duca, Benedikt Koell, Andreas A Kammerlander, Robin Ristl, Irene M Lang, Gerald Maurer, Julia Mascherbauer, Diana Bonderman

PLoS One (PLOS) Austria, 30 July 2015

Cardiology

Key words: Extracellular matrix, biopsy, blood pressure, heart failure, hemodynamics, echocardiography, pulmonary arteries, ejection fraction

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

1953
Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production

WY Fang, YW Chen, JR Hsiao, CS Liu, YZ Kuo, YC Wang, KC Chang, ST Tsai, MZ Chang, SH Lin, LW Wu

Oncotarget (Impact Journals) Taiwan, 22 July 2015

Oncology

Key words: S100A9, oral cancer, recurrence, IL-6, macrophages

Organism: Human

Tissue: Skin

Pathological State: Cancer

1954
Development of Blood and Lymphatic Endothelial Cells in Embryonic and Fetal Human Skin

Schuster C, Mildner M, Botta A, Nemec L, Rogojanu R, Beer L, Fiala C, Eppel W, Bauer W, Petzelbauer P, Elbe-Bürger A

The American Journal of Pathology (Elsevier) Austria, 16 July 2015

Pathology

Key words: Blood, lymphatic endothelial cells, embryonic, fetal human skin

Organism: Human

Tissue: Skin

1955
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Inge C van Gool, Florine A Eggink, Luke Freeman-Mills, Ellen Stelloo, Emanuele Marchi, Marco de Bruyn, Claire Palles, Remi A Nout, Cor D de Kroon, Elisabeth M Osse, Paul Klenerman, Carien L Creutzberg, Ian PM Tomlinson, Vincent THBM Smit, Hans W Nijman, Tjalling Bosse, David N Church

Clinical Cancer Research (AACR Publications) The Netherlands, UK, 15 July 2015

Oncology

Key words: Pole proofreading mutation, antitumor, immune response, endometrial cancer

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

1956
Langerhans Cells Maintain Local Tissue Tolerance in a Model of Systemic Autoimmune Disease

Jennifer K King, Rachael L Philips, Anna U Eriksson, Peter J Kim, Ramesh C Halder, Delphine J Lee, Ram Raj Singh

The Journal of Immunology (American Association of Immunologists) USA, 15 July 2015

Immunology

Key words: Lupus, langerhans cells

Organism: Mouse

Tissue: Skin

1957
mi R‐135b‐and mi R‐146b‐dependent silencing of calcium‐sensing receptor expression in colorectal tumors

Irfete S Fetahu, Samawansha Tennakoon, Kate E Lines, Charlotte Gröschel, Abhishek Aggarwal, Ildiko Mesteri, Sabina Baumgartner‐Parzer, Robert M Mader, Rajesh V Thakker, Enikő Kállay

International Journal of Cancer (Wiley) Austria, UK, 14 July 2015

Oncology

Key words: calcium‐sensing receptor, microRNAs, colorectal cancer, miR‐135b, miR‐146b

Organism: Human

Pathological State: Cancer

Cell Line: Caco2 cells, HT29 cells

1958
miR-135b- and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors

Irfete S Fetahu, Samawansha Tennakoon, Kate E Lines, Charlotte Gröschel, Abhishek Aggarwal, Ildiko Mesteri, Sabina Baumgartner-Parzer, Robert M Mader, Rajesh V Thakker, Eniko Kállay

International Journal of Cancer (Wiley) Austria, UK, 14 July 2015

Oncology

Key words: Calcium-sensing receptor, microRNAs, colorectal cancer, miR-135b, miR-146b

Organism: Human

Pathological State: Cancer

Cell Line: Caco2 cells

1959
Tumor dosimetry for I-131 trastuzumab therapy in a Her2+ NCI N87 xenograft mouse model using the Siemens SYMBIA E gamma camera with a pinhole collimator

Young Sub Lee, Jin Su Kim, Kyung Deuk Cho, Joo Hyun Kang, Sang Moo Lim

Journal of Instrumentation (IOP Science) South Korea, 06 July 2015

Oncology

Key words: Tumor dosimetry, xenograft mouse model, gamma camera, Siemens

Organism: Mouse

Pathological State: Cancer

Cell Line: Her2 Cells

1960
Male-Specific Alleviation of Iron-Induced Striatal Injury by Inhibition of Autophagy

Li-Fang Wang, Kazunari K Yokoyama, Tzu-Yin Chen, Hsiu-Wen Hsiao, Pei-Chi Chiang, Ya-Ching Hsieh, Steven Lo, Chin Hsu

PLoS One (PLOS) Taiwan, USA, 06 July 2015

Neuroscience

Key words: Autophagic cell death, neurons, neostriatum, neuronal tuning, histology, DNA fragmentation, mice, ovariectomy

Organism: Mouse

Tissue: Brain

Pathological State: Stratial Injury

1961
T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine

Kristen L Dennis, Abdulrahman Saadalla, Nichole R Blatner, Shuya Wang, Vysak Venkateswaran, Fotini Gounari, Hilde Cheroutre, Casey T Weaver, Axel Roers, Nejat K Egilmez, Khashayarsha Khazaie

Cancer Immunology Research (AACR Publications) USA, Germany, 01 July 2015

Oncology

Key words: T -cell, IL10, tumor immune surveillance, small intestine

Organism: Mouse

Tissue: Small Intestine

1962
Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue

Rik Mencke, Geert Harms, Katarina Mirkovic, Joyce Struik, Joris Van Ark, Ellen Van Loon, Melissa Verkaik, Martin H De Borst, Clark J Zeebregts, Joost G Hoenderop, Marc G Vervloet, Jan-Luuk Hillebrands

Cardiovascular Research (Oxford University Press) The Netherlands, 01 July 2015

Cardiology

Key words: Membrane-bound Klotho, uraemic human vascular tissue

Organism: Human

Tissue: Kidney, Blood Vessels

1963
Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons

Isabella Rauch, Felix Rosebrock, Eva Hainzl, Susanne Heider, Andrea Majoros, Sebastian Wienerroither, Birgit Strobl, Silvia Stockinger, Lukas Kenner, Mathias Müller, Thomas Decker

Molecular and Cellular Biology (ASM) Austria, 01 July 2015

Immunology

Key words: IRF9, intestinal inflammation, interferons

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

1964
miR-22 and miR-29a are members of the androgen receptor cistrome modulating LAMC1 and Mcl-1 in prostate cancer

Lorenza Pasqualini, Huajie Bu, Martin Puhr, Narisu Narisu, Johannes Rainer, Bettina Schlick, Georg Schäfer, Mihaela Angelova, Zlatko Trajanoski, Stefan T Börno, Michal R Schweiger, Christian Fuchsberger, Helmut Klocker

Molecular Endocrinology (Oxford University Press) Austria, USA, Italy, Germany, 01 July 2015

Endocrinology, Oncology

Key words: miR-22, miR-29a, Androgen Receptor Cistrome, LAMC1, Mcl-1, Prostate Cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1965
Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo

Fariba Poosti, Bao Tung Pham, Dorenda Oosterhuis, Klaas Poelstra, Harry van Goor, Peter Olinga, Jan-Luuk Hillebrands

Disease Models and Mechanisms (The Company of Biologists) The Netherlands, 24 June 2015

Nephrology

Key words: Drug targeting, Fibrosis, Kidney, Tissue slices

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Fibrosis

1966
Lanreotide-conjugated PEG-DSPE micelles: an efficient nanocarrier targeting to somatostatin receptor positive tumors

Nan Zheng, Wenbing Dai, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Kun Wang, Jian Lia, Qiang Zhang

Journal of Drug Targeting (Taylor and Francis) China, 24 June 2015

Oncology

Key words: Lanreotide, over-express somatostatin receptor 2, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (poly-(ethylene glycol))-2000]

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1967
Memantine attenuates delayed vasospasm after experimental subarachnoid hemorrhage via modulating endothelial nitric oxide synthase

CY Huang, LC Wang, YS Shan, CH Pan, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan, 23 June 2015

Neuroscience

Key words: memantine, nitric oxide synthase, subarachnoid hemorrhage, vasospasm

Organism: Rat

Tissue: Brain

Pathological State: Vasospasm

1968
STAT3 regulated ARF expression suppresses prostate cancer metastasis

Jan Pencik, Michaela Schlederer, Wolfgang Gruber, Christine Unger, Steven M Walker, Athena Chalaris, Isabelle J Marié, Melanie R Hassler, Tahereh Javaheri, Osman Aksoy, Jaine K Blayney, Nicole Prutsch, Anna Skucha, Merima Herac, Oliver H Krämer, Peter Mazal, Florian Grebien, Gerda Egger, Valeria Poli, Wolfgang Mikulits et al

Nature Communications (Nature) Austria, UK, Germany, USA, Italy, Sweden, 22 June 2015

Oncology

Key words: STAT3 and p14ARF expression, PI3K–AKT–mTOR signalling pathway, ARF–Mdm2–p53 tumour suppressor axis

Organism: Mouse

Tissue: Xenograft Tumor, Colon

Pathological State: Cancer

1969
The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia

Stephanie M Rangel, Maureen H Diaz, Claire A Knoten, Angelica Zhang, Alan R Hauser

PLoS Pathogens (PLOS) USA, 19 June 2015

Pulmonology

Key words: Pneumocytes, pneumonia, bacterial pathogens, pseudomonas aeruginosa, pulmonary imaging, cell staining, phagocytes, blood

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

1970
Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress

Jan-Renier AJ Moonen, Ee Soo Lee, Marc Schmidt, Monika Maleszewska, Jasper A Koerts, Linda A Brouwer, Theo G Van Kooten, Marja JA Van Luyn, Clark J Zeebregts, Guido Krenning, Martin C Harmsen

Cardiovascular Research (Oxford University Press) The Netherlands, Germany, 17 June 2015

Cardiology

Key words: LRRFIP1, EMT, Wnt/β-catenin signaling, β-catenin destruction complex, Reverse EMT

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

1971
Left Shift 1+ flag for the detection of band neutrophils: interlaboratory variations and recommendations for the routine laboratory

F WEERKAMP, P H TAAL, B A De BOER and ON BEHALF OF THE ADdifVIA WORKING GROUP

International Journal of Laboratory Hematology (Wiley) The Netherlands, 16 June 2015

Hematology

Key words: Differential leukocyte count, left shift flag, band neutrophils, routine laboratory

Organism: Human

Cell Line: Blood

1972
Image analysis for accurately counting CD4+ and CD8+ T cells in human tissue

Kurt Diema, Amalia Magaret, Alexis Klock, Lei Jina, Jia Zhu, Lawrence Corey

Journal of Virological Methods (Elsevier) USA, 12 June 2015

Virology

Key words: Cell counting, immunohistochemistry (IHC), software cell counting, HSV-2, cellProfiler

Organism: Human

Tissue: Penis

Pathological State: Virus Infection

1973
298 MAST CELLS ARE ABUNDANT IN CUTANEOUS T‐CELL LYMPHOMAS AND CORRELATE WITH DISEASE STAGE

P Gorniak, B Budziszewska, B Pula, M Wasylecka, K Borg, G Nowak, H Makuch - Lasica, E Lech - Maranda, K Warzocha, P Juszczynski

Hematological Oncology (Wiley) Poland, 09 June 2015

Oncology

Key words: Cerebral ischemia–reperfusion injury, oxidative stress, apoptosis, superoxide, NADPH oxidase

Organism: Human

Tissue: Lymphoid Tissue

1974
Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

Tung-Hung Su, Chung-Wai Shiau, Ping Jao, Chen-Hua Liu, Chun-Jen Liu, Wei-Tien Tai, Yung-Ming Jeng, Hung-Chih Yang, Tai-Chung Tseng, Hsiang-Po Huang, Huei-Ru Cheng, Pei-Jer Chen, Kuen-Feng Chen, Jia-Horng Kao, Ding-Shinn Chen

PNAS (PNAS) Taiwan, 09 June 2015

Cell Biology

Key words: Hepatic stellate, cell STAT3 SHP-1, hepatitis B, liver fibrosis

Pathological State: Liver Fibrosis

1975
ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors

Liem T Nguyen, Maria S Tretiakova, Mark R Silvis, Jared Lucas, Olga Klezovitch, Ilsa Coleman, Hamid Bolouri, Vassily I Kutyavin, Colm Morrissey, Lawrence D True, Peter S Nelson, Valeri Vasioukhin

Cancer Cell (Cell Press) USA, 08 June 2015

Oncology

Key words: Prostate cancer, actin cytoskeleton

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1976
CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models

JF Xu, XH Pan, SJ Zhang, C Zhao, BS Qiu, HF Gu, JF Hong, L Cao, Y Chen, B Xia, Q Bi, YP Wang

Oncotarget (Impact Journals) China, 08 June 2015

Oncology

Key words: osteosarcoma, CD47, antibody, immunotherapy

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

1977
The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing

Soung-Hoon Lee, Mi-Yeon Kim, Hyun-Yi Kim, Young-Mi Lee, Heesu Kim, Kyoung Ae Nam, Mi Ryung Roh, Do Sik Min, Kee Yang Chung, Kang-Yell Choi

Journal of Experimental Medicine (Rockefeller University Press) South Korea, 08 June 2015

Regenerative Medicine

Key words: Idiopathic pulmonary fibrosis, mesenchymal stem cell, mitochondrial membrane

Organism: Human

Tissue: Skin

Pathological State: Skin Wound

1978
AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis

Jino Park, Michaela Schlederer, Martin Schreiber, Ryan Ice, Olaf Merkel, Martin Bilban, Sebastian Hofbauer, Soojin Kim, Joseph Addison, Jie Zou, Chunyan Ji, Silvia T Bunting, Zhengqi Wang, Menachem Shoham, Gang Huang, Zsuzsanna Bago-Horvath, Laura F Gibson, Yon Rojanasakul, Scot Remick, Alexey Ivanov, Elena Pugacheva, Kevin D Bunting, Richard Moriggl, Lukas Kenner, William Tse

Oncotarget (Impact Journals) USA, Austria, Germany, China, 07 June 2015

Oncology

Key words: AF1q, TCF7, CD44, Wnt, metastasis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1979
Atopic donor status does not influence the uptake of the major grass pollen allergen, Phl p 5, by dendritic cells

Kazem Ashjaei, Dieter Palmberger, Merima Bublin, Erika Bajna, Heimo Breiteneder, Reingard Grabherr, Isabella Ellinger, Karin Hoffmann-Sommergruber

Journal of Immunological Methods (Elsevier) Austria, 05 June 2015

Immunology

Key words: Allergen, Endocytosis, Grass pollen, Monocyte derived dendritic cells, Phl p 5, SF-nsLTP

Organism: Human

Pathological State: Allergy

Cell Line: Blood

1980
Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6

Hui-Wen Chiu, Shu-Wen Lin, Li-Ching Lin, Yung-Ho Hsu, Yuh-Feng Lin, Sheng-Yow Ho, Yuan-Hua Wu, Ying-Jan Wang

Cancer Letters (Elsevier) Taiwan, 04 June 2015

Oncology

Key words: Radiation, Proteasome inhibitor, Autophagy, Endoplasmic reticulum stress, Pancreatic cancer

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

1981
Mast cell-macrophage dynamics in modulation of dengue virus infection in skin

Ya-Ting Chu, Shu-Wen Wan, Robert Anderson, Yee-Shin Lin

Immunology (Wiley) Taiwan, Canada, 04 June 2015

Immunology

Key words: Dengue virus, KitW-sh/W-sh mice, macrophage, mast cell

Organism: Mouse

Tissue: Skin

Pathological State: Dengue Virus Infection

1982
Silencing of LRRFIP1 reverses the epithelial–mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway

Daisuke Douchi, Hideo Ohtsuka, Kyohei Ariake, Kunihiro Masuda, Shuhei Kawasaki, Kei Kawaguchi, Koji Fukase, Masaya Oikawa, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno

Cancer Letters (Elsevier) Japan, 03 June 2015

Oncology

Key words: LRRFIP1, EMT, Wnt/β-catenin signaling, β-catenin destruction complex, Reverse EMT

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

1983
Prognostic Significance and Determinants of the 6-Min Walk Test in Patients With Heart Failure and Preserved Ejection Fraction

Caroline Zotter-Tufaro, Julia Mascherbaue, Franz Duca, Benedikt Koell, Stefan Aschaue, Andreas A Kammerlande, Adelheid Panzenboeck, Roela Sadushi-Kolici, Christine Bangert, Daniela Laimer, Robin Ristl, Irene M Lang, Diana Bonderman

JACC: Heart Failure (Elsevier) Austria, 01 June 2015

Cardiology

Key words: cardiac catheterization, exercise test, extracellular matrix, pulmonary circulation

Organism: Human

Tissue: Heart

Pathological State: Cardiac Fibrosis

1984
Mastocytosis: the new differential diagnosis of CD30-positive neoplasms

Irina Maric, Katherine R Calvoa

Leukemia and Lymphoma (Taylor and Francis) USA, 01 June 2015

Oncology

Key words: Mastocytosis disease

1985
Clinically applicable magnetic-labeling of natural killer cells for MRI of transcatheter delivery to liver tumors: preclinical validation for clinical translation

Kangan Li, Andrew C Gordon, Linfeng Zheng, Weiguo Li, Yang Guo, Jing Sun, Guixiang Zhang, Guohong Han, Andrew C Larson, Zhuoli Zhang

Nanomedicine (Future Medicine) China, USA, 01 June 2015

Nanomedicine

Key words: Intraportal vein, heparin-protamine-ferumoxytol, HPF-labeled NK cells

Organism: Rat

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

1986
Paracrine factors of human amniotic fluid-derived mesenchymal stem cells show strong anti-fibrotic properties by inhibiting myofibroblast differentiation and collagen synthesis

MM Mia, RA Bank

Journal of Stem Cell Research and Therapy (OMICS) The Netherlands, 21 May 2015

Stem Cell Research

Key words: Fibrosis, Fibroblasts, Myofibroblasts, TGFβ1, Mesenchymal stem cells, Extracellular matrix

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

1987
Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia–reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways

X Meng, M Wang, X Wang, G Sun, J Ye, H Xu, X Sun

Free Radical Research (Taylor and Francis) China, 20 May 2015

Neuroscience

Key words: Cerebral ischemia–reperfusion injury, oxidative stress, apoptosis, superoxide, NADPH oxidase

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

1988
Hypoxia-preconditioned mesenchymal stem cells attenuate bleomycin-induced pulmonary fibrosis

Ying-Wei Lan, Kong-Bung Choo, Chuan-Mu Chen, Tsai-Hsien Hung, Young-Bin Chen, Chung-Hsing Hsieh, Han-Pin Kuo, Kowit-Yu Chong

Stem Cell Research & Therapy (BMC) China, Malaysia, 20 May 2015

Stem Cell Research

Key words: Bleomycin, diopathic pulmonary fibrosis, hypoxia-inducible factor, hepatocyte growth factor, connective tissue growth factor

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

1989
Texture analysis of 125I-A5B7 anti-CEA antibody SPECT differentiates metastatic colorectal cancer model phenotypes and anti-vascular therapy response

V Rajkumar, V Goh, M Siddique, M Robson, G Boxer, RB Pedley, GJR Cook

British Journal of Cancer (Wiley) UK, 19 May 2015

Oncology

Key words: Cancer models, Colorectal cancer Computed tomography Tumour heterogeneity

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

1990
Intracellular calcium levels as screening tool for nanoparticle toxicity

Claudia Meindl, Tatjana Kueznik, Martina Bösch, Eva Roblegg, Eleonore Fröhlich

Journal of Applied Toxicology (Wiley) Austria, 14 May 2015

Toxicology

Key words: Nanoparticles, cytotoxicity, apoptosis, lysosomes, calcium imaging

Organism: Human

Cell Line: EAhy926 cells (Human endothelial cell line)

1991
Expression of Interferon γ by Decidual Cells and Natural Killer Cells at the Human Implantation Site

Chie-Pein Chen,Longzhu Piao, Xilin Chen, Jianhua Yu, Rachel Masch, Frederick Schatz, Charles J Lockwood, S Joseph Huang

Reproductive Sciences (SAGE Journals) Taiwan, USA, 11 May 2015

Reproductive Medicine

Key words: Interferon γ, NK cells, decidual cells

Organism: Human

Tissue: Endometrium

1992
K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis

KH Koo, WJ Jeong, YH Cho, JC Park, DS Min, KY Choi

Oncotarget (Impact Journals) South Korea, 08 May 2015

Oncology

Key words: endometrial cancer, estrogen, tumorigenesis, K-Ras, PKCδ

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

1993
The systemic multiplication of Gallibacterium anatis in experimentally infected chickens is promoted by immunosuppressive drugs which have a less specific effect on the depletion of leukocytes

Surya Paudel, Claudia Hess, Patricia Wernsdorf, Tobias Käser, Sarah Meitz, Erika Jensen-Jarolim, Michael Hess, Dieter Liebhart

Veterinary Immunology and Immunopathology (Elsevier) Austria, 08 May 2015

Immunology

Key words: Gallibacterium anatis, chickensc, leukocyte quantification, non-selective immunosuppression

Organism: Chicken

Tissue: Spleen

Pathological State: Gallibacterium Anatis Infection

1994
siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown

Pratik S Randeria, Mark A Seeger, Xiao-Qi Wang, Heather Wilson, Desmond Shipp, Chad A Mirkin, Amy S Paller

PNAS (PNAS) USA, 05 May 2015

Dermatology

Key words: SNA, nanoparticle, siRNA, GM3 synthase, diabetic wound healing

Organism: Mouse

Tissue: Adipose Tissue, Muscle

Pathological State: Obesity, Diabetes

1995
CCL7 contributes to the TNF-alpha-dependent inflammation of lesional psoriatic skin

Patrick M Brunner, Elisabeth Glitzner, Baerbel Reininger, Irene Klein, Georg Stary, Michael Mildner, Pavel Uhrin, Maria Sibilia, Georg Stingl

Experimental Dermatology (Wiley) Austria, 04 May 2015

Dermatology

Key words: CCL7, chemokines, myeloid cells, psoriasis, TNF-α

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

1996
Effect of Sodium-Glucose Cotransport Inhibition on Polycystic Kidney Disease Progression in PCK Rats

Sarika Kapoor, Daniel Rodriguez, Meliana Riwanto, Ilka Edenhofer, Stephan Segerer, Katharyn Mitchell, Rudolf P Wüthrich

PLoS One (PLOS) Switzerland, 30 April 2015

Nephrology

Key words: sodium-glucose-cotransporter-2 (SGLT2), polycystic kidney disease, aquaretic drug tolvaptan

Organism: Rat

Tissue: Kidney

Pathological State: Kidney Disease

1997
Frontal cortex and hippocampus neurotransmitter receptor complex level parallels spatial memory performance in the radial arm maze

Bharanidharan Shanmugasundaram, Ajinkya Sase, András G Miklosi, Fernando J Sialana, Saraswathi Subramaniyan, Yogesh D Aher, Marion Gröger, Harald Höger, Keiryn L Bennett, Gert Lubec

Behavioural Brain Research (Elsevier) Austria, 28 April 2015

Neuroscience

Key words: Radial arm maze, Neurotransmitter receptor complex, Blue native PAGE, Spatial memory, D1-GluN1 complex

Organism: Rat

Tissue: Brain

1998
Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2,5) translocation

Olaf Merkel, Frank Hamacher, Robert Griessl, Lisa Grabner, Ana-Iris Schiefer, Nicole Prutsch, Constance Baer, Gerda Egger, Michaela Schlederer, Peter William Krenn, Tanja Nicole Hartmann, Ingrid Simonitsch-Klupp, Christoph Plass, Philipp Bernhard Staber, Richard Moriggl, Suzanne D Turner, Richard Greil, Lukas Kenner

The Journal of Pathology (Wiley) Germany, Austria, UK, 27 April 2015

Oncology

Key words: miR-155, ALCL, ALK kinase, cytokines, IL-21, IL-22, IL-10

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1999
Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22α expression in endothelial cells in response to interleukin-1β and transforming growth factor-β2

Monika Maleszewska, Rutger AF Gjaltema, Guido Krenning, Martin C Harmsen

Cellular Signalling (Elsevier) The Netherlands, 24 April 2015

Cell Biology

Key words: Endothelial cell, EZH2, SM22α, inflammation, fibrosis, chromatin

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

2000
Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation

Dong-Hyun Kima, Andrew C Larson

Biomaterials (Elsevier) USA, 17 April 2015

Nanomedicine

Key words: Gold nanoparticles, bile acid, green chemistry, photothermal treatment, nanomedicine

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

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