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  • RESEARCH POWERED BY TISSUEGNOSTICS

    White Papers


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White Papers

Please find a currated selection of research made possible by TissueGnostics software and systems below or in our searchable data base.

 

  • Anti-Neoplastic Effects of Calcium

    Striosomes Causal Changes Task Engagement

    Febuary, 2021

    Learning through affective responses, in which experiences are regarded as having a positive or negative valence (e.g., pleasure or fear, respectively), requires a judgment of the relative value of options. Several studies have linked a cluster of neurons in the subcortical basal ganglia, known as the striatum, to learning these valence-based responses.

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  • Anti-Neoplastic Effects of Calcium

    Mediating Palatability ­Guided Food and Water Consumption with Hindbrain Double­ Negative Feedback

    October, 2020

    Animal survival relies on neural mechanisms that trigger behaviors to meet basic bodily needs. Traditionally, motivated behaviors have been categorized into three phases.

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  • Anti-Neoplastic Effects of Calcium

    COVID­-19 Shows a Loss of Bcl­6­ Expressing T Follicular Helper Cells and Germinal Centers

    August, 2020

    A groundbreaking publication in the journal Cell suggests that in COVID-19 patients the differentiation of Tfh cells and formation of germinal centers within lymph nodes and spleen is inhibited. Molecules such as Bcl-6 were assessed using the TissueFAXS platform including the analysis applications StrataQuest and TissueQuest.

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  • Anti-Neoplastic Effects of Calcium

    Characterizing the Complex Microenvironment of Individual Immune Cells

    April, 2019

    Research groups from Yale University, USA published a paper in 'Cytometry' focusing on the phenotyping, quantification and visualization of immune cells and immune cell clusters within tissue sections using co-registration and IF multiplexed tissue cytometry. 

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  • Anti-Neoplastic Effects of Calcium

    Imaging of neural contributions to voluntary hand movement

    Febuary, 2019

    Skilled motor behavior requires the precise exchange of information between the muscles of the body and various levels of the central nervous system (CNS). Motor behavior, limb mechanics and neural control must be precisely coordinated in order to achieve the required movement.

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  • Anti-Neoplastic Effects of Calcium

    DNA-Binding of the Tet-Transactivator Curtails Antigen-Induced Lymphocyte Activation in Mice

    October, 2017

    Research groups from Austria, Australia, England and The Netherlands published a paper in 'Nature Communications' about the Tet-transactivator imparing the antigen-induced lymphocyte activation in mice.

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  • Anti-Neoplastic Effects of Calcium

    Tumor Specific Regulatory T Cells in the Bone Marrow of Breast Cancer Patients Selectively Upregulate the Emigration Receptor S1P1

    Febuary, 2017

    Groups from Germany (Heidelberg, Jena)  published a paper in the Journal 'Cancer Immunology, Immunotherapy'  regarding tumor-specifc regulatory T cells in the bone marrow of breast cancer patients.

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  • Anti-Neoplastic Effects of Calcium

    Quantitative Comparison and Reproducibility of Pathologist Scoring and Digital Image Analysis of Estrogen Receptor β2 Immunohistochemistry in Prostate Cancer

    July, 2016

    Research groups from USA, published a paper in 'Diagnostic Pathology' dealing with quantitative comparison and reproducibility of pathologist scoring and digital image analysis in prostate cancer.

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  • Anti-Neoplastic Effects of Calcium

    Anti-Neoplastic Effects of Calcium in Colorectal Cancer Potentiated by Active Vitamin D

    Febuary, 2015

    Groups from Vienna published a paper in 'The Journal of Steroid Biochemistry and Molecular Biology' about Vitamin D potentiating the anti-neoplastic effects of calcium in the colon.

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