NETotic Cells

FEATURED PUBLICATION

High Presence of NETotic Cells and Neutrophil Extracellular Traps in Vaginal Discharges of Women with Vaginitis: An Exploratory Study
Cells

Zambrano et al. investigated a rarely addressed issue in public health – infectious vaginitis – by characterizing NETotic cells and neutrophil extracellular traps (NETs) in vaginal discharges of women with vaginitis. Identification of extracellular DNA, neutrophil elastase, and citrullinated histones was performed with TissueFAXS i Plus system.

EMT

FEATURED PUBLICATION

Interplay between Partial EMT and Cisplatin Resistance as the Drivers for Recurrence in HNSCC
Biomedicines

In a recent study, Ingruber et al. investigated the role of partial epithelial to mesenchymal transition (pEMT)-related proteins in modulating Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC). To perform an in-depth quantitative analysis, the power of TissueFAXS platform and StrataQuest software was utilized.

Expression and clinical significance

FEATURED PUBLICATION

Expression and clinical significance of VISTA, B7-H3, and PD-L1 in glioma
Clinical Immunology

In a recent study, Wang et al. investigated RNA and protein expression of various immune checkpoint molecules, highlighting their prognostic value. To scan multiple markers simultaneously on TMAs the multispectral tissue cytometer TissueFAXS SPECTRA was used, as well as StrataQuest for in-depth phenotyping.

P2X7 receptor

FEATURED PUBLICATION

P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma
Frontiers in Oncology

Arnaud-Sampaio et al. addressed the persistent problem of drug resistance in cancer and elucidated the role of the P2X7 receptor in chemoresistance, using TissueFAXS platform for image acquisition and StrataQuest software for in-depth cytometric quantifications. The paper was published in Frontiers in Oncology.

Cytotoxic CD8+ T cells may be drivers

FEATURED PUBLICATION

Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome
scientific reports

In this study, published in scientific reports Nature, Kaneko et al. investigated the role of CD4+ and CD8+ T cell subsets in salivary glands of patients with Sjögren’s syndrome. In order to perform an in-depth quantitative analysis, the power of TissueFAXS platform, and both TissueQuest and StrataQuest software were utilized.

Adverse Effects of Single

FEATURED PUBLICATION

A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells
cancers

This study from Liang et al. (University of Gothenburg) assessed phenotypic and functional characteristics of tumor infiltrating lymphocytes within colorectal liver metastases (CRLM). For the in-situ tissue cytometry analysis, with the main focus on CD103+CD8+ TRM cells, the power of TissueFAXS CHROMA and StrataQuest was utilized.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Functional Impairment

FEATURED PUBLICATION

Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia
Immunity

In a recent study published in the journal Immunity, Collins et al (Ragon Institute of MGH, MIT and Harvard) were able to show key immunologic and virologic parameters of durable HIV control. For high resolution visualization of the virus, lymph node tissues were marked with HIV specific RNAScope probes and acquired using TissueFAXS Q.

Filter publications

Customer Publications (A total of 2312 papers published)

601
Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia

O Nonn, C Fischer, S Geisberger, A El-Heliebi, T Kroneis, D Forstner, G Desoye, AC Staff, M Sugulle, R Dechend, U Pecks, M Kollmann, C Stern, JE Cartwright, GS Whitley, B Thilaganathn, C Wadsack, B Huppertz, F Herse, M Gauster

Hypertension (American Heart Association) Austria, Germany, Norway, UK, 29 March 2021

Reproductive Medicine

Key words: Candesartan, Leptin, Oxygen, Respiration, Trophoblasts

Organism: Human

Tissue: Placenta

602
Expression of CD9 on porcine lymphocytes and its relation to T cell differentiation and cytokine production

JV Milburn, A Hoog, S Winkler, KA van Dongen, J Leitner, M Patzl, A Saalmüller, K de Luca, P Steinberger, KH Mair, W Gerner

Developmental & Comparative Immunology (Elsevier) Austria, France, 27 March 2021

Immunology

Key words: Tetraspanin, CD9, Porcine, Lymphocyte, Memory

Organism: Mouse

Tissue: Lymphoid Tissue

603
Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia

L Morales-Nebreda, KA Helmin, MAT Acosta, NS Markov, JY Hu, AM Joudi, R Piseaux-Aillon, H Abdala-Valencia, Y Politanska, BD Singer

JCI Insight (The American Society for Clinical Investigation) USA, 22 March 2021

Aging

Key words: Aging, T Cells

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection, Pneumonia

604
Selective Denervation of the Facial Dermato-Muscular Complex in the Rat: Experimental Model and Anatomical Basis

V Tereshenko, DC Dotzauer, U Maierhofer, C Festin, M Luft, G Laengle, O Politikou, HJ Klein, R Blumer, OC Aszmann, KD Bergmeister

Frontiers in Neuroanatomy (Frontiers Media S.A.) Austria, Switzerland, 22 March 2021

Neuroscience

Key words: Facial Nerve, Trigeminal Nerve, Motor-Sensory Control, Facial Muscles, Axon Quantification, Whole-Mount Staining

Organism: Rat

Tissue: Nerves

605
Inhibition of vascular adhesion protein‐1 enhances the anti‐tumor effects of immune checkpoint inhibitors

T Kinoshita, MA Sayem, T Yaguchi, B Kharma, K Morii, D Kato, S Ohta, Y Mashima, H Asamura, Y Kawakami

Cancer Science (Japanese Cancer Association) Japan, Bangladesh, 18 March 2021

Oncology

Key words: CTLs, H2O2, ICIs, Immunosuppression, VAP‐1 Inhibitor

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

606
Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis

W Cui, D Liu, W Gu, B Chu

Cell Death & Differentiation (Nature) China, USA, 17 March 2021

Oncology

Key words: Cancer Metabolism, Phospholipids

Organism: Human

Tissue: Kidney

Pathological State: Cancer

607
Luteolin Modulates the NF-E2-Related Factor 2/Glutamate–Cysteine Ligase Pathway in Rats with Spinal Cord Injury

J Fu, W Xu, Y Zhang, H Sun, J Zhao

Journal of Medicinal Food (Mary Ann Liebert Inc.) China, 16 March 2021

Neuroscience

Key words: Luteolin, Nrf2/GCL Pathway, Oxidative Stress, Spinal Cord Injury

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

608
Machine perfused donor kidneys as a source of human renal endothelial cells

RGM Lammerts, LM Lagendijk, G Tiller, WA Dam, HL Lancaster, MR Daha, MA Seelen, BG Hepkema, RA Pol, HGD Leuvenink, G Molema, J van den Born, SP Berger, the COMBAT Consortium

American Journal of Physiology (APS Journals) The Netherlands, 15 March 2021

Nephrology

Key words: Kidney, Transplantation, Endothelial Cells, Machine Perfusion, Perfusate

Organism: Human

Pathological State: Organ Transplantation

Cell Line: MP-PRECs

609
Genetic Drivers of Head and Neck Squamous Cell Carcinoma: Aberrant Splicing Events, Mutational Burden, HPV Infection and Future Targets

Z Dlamini, M Alaouna, S Mbatha, A Bhayat, M Mabongo, A Chatziioannou, R Hull

Genes (MDPI) South Africa, Greece, 15 March 2021

Oncology

Key words: Head and Neck Squamous Cell Carcinoma (HNSCC), Aberrant Splicing Events, Human Papillomavirus (HPV) Infection, Non-Coding RNA (ncRNA), Methylation, Mutational Burden

Pathological State: Cancer, HPV Infection

610
A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice

HL Lee, SW Hee, CF Hsuan, W Yang, JY Huang, YL Lin, CN Hsu, JJ Hwang, SM Chen, ZZ Ding, TY Lee, YC Lin, FC Tsai, WL Su, LY Chueh, ML Hsieh, CH Chen, D Mochly-Rosen, YC Chang, LM Chuang

Antioxidants (MDPI) Taiwan, USA, 13 March 2021

Cardiology, Endocrinology

Key words: Diabetic Cardiomyopathy, 4-Hydroxy-2-Nonenal, Mitochondrial Aldehyde Dehydrogenase 2, AD-9308

Organism: Mouse

Tissue: Heart

Pathological State: Diabetes

611
MicroRNA-126 inhibits pathological retinal neovascularization via suppressing vascular endothelial growth factor expression in a rat model of retinopathy of prematurity

YY Fan, CH Liu, AL Wu, HC Chen, YJ Hsueh, KJ Chen, CC Lai, CY Huang, WC Wu

European Journal of Pharmacology (Elsevier) Taiwan, 13 March 2021

Pharmacology

Key words: miR-126, Retinal Pigment Epithelium Cells, Vascular Endothelial Growth Factor, Oxygen-Induced Retinopathy, Neovascularization, Rat

Organism: Rat

Tissue: Eye

Pathological State: Retinopathy

612
N-Acetyl Cysteine Overdose Inducing Hepatic Steatosis and Systemic Inflammation in Both Propacetamol-Induced Hepatotoxic and Normal Mice

GG Liou, CC Hsieh, YJ Lee, PH Li, MS Tsai, CT Li, SH Wang

Antioxidants (MDPI) Taiwan, 12 March 2021

Hepathology

Key words: Acetaminophen Overdose, N-Acetyl Cysteine Overdose, Two Inbred Mouse Strains, Hepatic Inflammation, Systemic Inflammation, Microvesicular Steatosis

Organism: Mouse

Tissue: Liver

Pathological State: Hepatic Steatosis, Systemic Inflammation

613
Dissecting pathways to thrombocytopenia in a mouse model of visceral leishmaniasis

GF Rani, O Preham, H Ashwin, N Brown, IS Hitchcock, PM Kaye

Blood Advances (ASH Publications) UK, 12 March 2021

Immunology

Key words: Blood Platelets, Infections, Leishmania Donovani, Leishmaniasis, Visceral, Mice, Thrombocytopenia, Drug Clearance, Thrombopoietin, Spleen, Liver

Organism: Mouse

Tissue: Liver

Pathological State: Leishmaniasis

614
CHPF Regulates the Aggressive Phenotypes of Hepatocellular Carcinoma Cells via the Modulation of the Decorin and TGF-β Pathways

CH Liu, BR Wu, YJ Ho, YH Chu, WC Hsu, TJ Tseng, JP Li, WC Liao

Cancers (MDPI) Taiwan, 12 March 2021

Oncology

Key words: Hepatocellular Carcinoma, Tumor Microenvironment, Chondroitin Polymerizing Factor, Chondroitin Sulfate, Decorin

Organism: Human

Tissue: Liver

Pathological State: Cancer

615
KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma

J Ingruber, D Savic, TB Steinbichler, S Sprung, F Fleischer, R Glueckert, G Schweigl, II Skvortsova, H Riechelmann, J Dudás

Cells (MDPI) Austria, 12 March 2021

Oncology

Key words: TissueFaxs, TWIST, ZEB, SCC-25, FaDu, UPCI-SCC090

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

616
Dietary Modification Alters the Intrarenal Immunologic Micromilieu and Susceptibility to Ischemic Acute Kidney Injury

J Jeon, K Lee, KE Yang, JE Lee, GY Kwon, W Huh, DJ Kim, YG Kim, HR Jang

Frontiers in Immunology (Frontiers Media S.A.) South Korea, 11 March 2021

Immunology, Nephrology

Key words: Diet, High-Salt Diet, High-Fat Diet, Acute Kidney Injury, Immunologic Micromilieu, Ischemia-Reperfusion Injury

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

617
Genome-wide 5-hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer

SL Wu, X Zhang, M Chang, C Huang, J Qian, Q Li, F Yuan, L Sun, X Yu, X Cui, J Jiang, M Cui, Y Liu, HW Wu, ZYLiang, X Wang, Y Niu, WM Tong, F jin

Genomics, Proteomics & Bioinformatics (Elsevier) China, 11 March 2021

Proteomics, Oncology

Key words: 5-Hydroxymethylcytosine (5hmC), Breast Cancer, Lymph Node Metastasis, MAP7D1, Biomarker

Organism: Human

Tissue: Breast, Lymphoid Tissue

Pathological State: Cancer

618
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma

P Kumthekar, CH Ko, T Paunesku, K Dixit, AM Sonabend, O Bloch, M Tate, M Schwartz, L Zuckerman, R Lezon, RV Lukas, B Jovanovic, K McCortney, H Colman, S Chen, B Lai, O Antipova, J Deng, L Li, S Tommasini-Ghelfi, LA Hurley, D Unruh, NV Sharma, M Kandpal, FM Kouri, RV Davuluri, DJ Brat, M Muzzio, M Glass, V Vijayakumar, J Heidel, FJ Giles, AK Adams, CD James, GE Woloschak, C Horbinski, AH Stegh

Science Translational Medicine (AAAS) USA, 10 March 2021

Oncology

Organism: Human

Tissue: Brain

Pathological State: Cancer

619
Aurka loss in CD19+ B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production

X Chen, C Wang, N Sun, S Pan, R Li, X Li, J Zhao, H Tong, Y Tang, J Han, J Qiao, H Qiu, H Wang, J Yang, T Ikezoe

Theranostics (Ivyspring International Publisher) China, Japan, 04 March 2021

Cell Biology

Key words: Aurora-A, Thrombopoietin, STAT3, IL-6, Megakaryocytopoiesis.

Organism: Mouse

Tissue: Spleen

620
CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment

WC Liao, HR Yen, CH Chen, YH Chu, YC Song, TJ Tseng, CH Liu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, 01 March 2021

Oncology

Key words: Breast Cancer, Chondroitin Sulfate, CHPF, Tumor Microenvironment, Syndecan-4

Organism: Human

Tissue: Breast

Pathological State: Cancer

621
Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury

S Yang, T Hu, H Liu, Y Lv, W Zhang, H Li, L Xuan, LL Gong, LH Liu

Biomedicine & Pharmacotherapy (Elsevier) China, USA, 27 February 2021

Gastroenterology

Organism: Mouse

Tissue: Small Intestine

622
Parathyroid hormone induces transition of myofibroblasts in arteriovenous fistula and increases maturation failure

CT Liu, SC Hsu, HL Hsieh, CH Chen, CY Chen, YM Sue, FY Lin, CM Shih, YT Shiu, PH Huang

Endocrinology (Oxford Academic) Taiwan, USA, 26 February 2021

Endocrinology

Key words: Arteriovenous Fistula (AVF), Fibrosis, Hemodialysis, Parathyroid Hormone (PTH)

Organism: Mouse

Tissue: Peritoneum, Muscle

623
Gastric Enzyme Supplementation Inhibits Food Allergy in a BALB/c Mouse Model

N Samadi, D Heiden, M Klems, M Salzmann, J Rohrhofer, E Weidmann, L Koidl, E Jensen-Jarolim, E Untersmayr

Nutrients (MDPI) Austria, 26 February 2021

Allergy Research

Key words: Food Allergy, Gastric Enzymes, Gastric Acid Suppression, Systemic Allergic Response, Allergy Prevention

Organism: Mouse

Tissue: Stomach

624
Genetic Background Effects on the Expression of an Odorant Receptor Gene

AG Leme Silva, MH Nagai, TS Nakahara, B Malnic

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) Brazil, 25 February 2021

Neuroscience

Key words: DNA Methylation, Odorant Receptor Gene, Olfactory Receptor Gene, Genetic Background, Gene Expression, Single Nucleotide Polymorphism

Organism: Mouse

Tissue: Nose

625
Regulation of pancreatic fibrosis by acinar cell-derived exosomal miR-130a-3p via targeting of stellate cell PPAR-γ

Q Wang, H Wang, Q Jing, Y Yang, D Xue, C Hao, W Zhang

Journal of Inflammation Research (Dovepress) China, 24 February 2021

Gastroenterology

Key words: Pancreatitis, Exosomes, miR-130a-3p, Pancreatic Fibrosis, PPAR- γ

Organism: Rat

Tissue: Pancreas

Pathological State: Pancreatitis

626
Pollen grain microscopic image classification using an ensemble of fine-tuned deep convolutional neural networks

A Mahbod, G Schaefer, R Ecker, I Ellinger

International Conference on Pattern Recognition (Springer) Austria, UK, 21 February 2021

Machine Learning

Key words: Medical Image Analysis

627
Accuracy of HPV E6/E7 mRNA examination using in situ hybridization in diagnosing cervical intraepithelial lesions

C Hui, H Bai, J Liu, X Lu, S Wang, Z Zhang, M Jin, Y Wang, Y Liu

Diagnostic Pathology (Springer) China, 19 February 2021

Pathology

Key words: Cervical Intraepithelial Neoplasia, CIN, Diagnostic Accuracy, E6/E7 mRNA, In Situ Hybridization

Organism: Human

Tissue: Cervix

Pathological State: Cervical lesions

628
T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells

Abigail E Schiff, Alice H Linder, Shillah N Luhembo, Stephanie Banning, Martin J Deymier, Thomas J Diefenbach, Amy K Dickey, Athe M Tsibris, Alejandro B Balazs, Josalyn L Cho, Benjamin D Medoff, Gerhard Walzl, Robert J Wilkinson, Wendy A Burgers, Björn Corleis, Douglas S Kwon

Scientific Reports (Nature) USA, South Africa, UK, Germany, 16 February 2021

Virology

Key words: HIV Infections, Monocytes and Macrophages, Mucosal Immunology, Retrovirus, Virology, Virus–Host Interactions

Organism: Human

Tissue: Lung

Pathological State: HIV infection

629
Imbalance of TGF-β1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness

J Ning, Y Ye, D Bu, G Zhao, T Song, P Liu, W Yu, H Wang, H Li, X Ren, G Ying, Y Zhao, J Yu

Molecular Therapy (Elsevier) China, 15 February 2021

Oncology

Organism: Human

Tissue: Liver

Pathological State: Cancer

630
Curcumin inhibits the growth of liver cancer by impairing myeloid‑derived suppressor cells in murine tumor tissues

S Tian, L Liao, Q Zhou, X Huang, P Zheng, Y Guo, T Deng, X Tian

Oncology Letters (Spandidos Publications) China, 12 February 2021

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

631
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4

T Guo, YH Bai, XJ Cheng, HB Han, H Du, Y Hu, SQ Jia, XF Xing, JF Ji

Cancer Communications (Wiley) China, 11 February 2021

Oncology

Key words: Gastric Cancer, Glucose Transporter 4, Glycolysis, Insulin Gene Enhancer Protein 1, Tumorigenesis

Organism: Human

Tissue: Stomach

Pathological State: Cancer

632
Global Analysis of Lysine Acetylome Reveals the potential role of CCL18 in non‐small cell lung cancer

S Kong, L Ding, C Fan, Y Li, C Wang, K Wang, W Xu, X Shi, Q Wu, F Wang

Proteomics (Wiley) China, 11 February 2021

Proteomics

Key words: Acetylome, CCL18, Non-Small Cell Lung Cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

633
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms

Wolf Eilenberg, Branislav Zagrapan, Sonja Bleichert, Nahla Ibrahim, Viktoria Knöbl, Annika Brandau, Luca Martelanz, Marie-Therese Grasl, Hubert Hayden, Paimann Nawrozi, Renata Rajic, Charlotte Häusler, Alexandros Potolidis, Nawa Schirwani, Andreas Scheuba, Johannes Klopf, Peter Teubenbacher, Markus P Weigl, Patrick Kirchweger, Dietrich Beitzke, Alexander Stiglbauer-Tscholakoff, Adelheid Panzenböck, Irene Lang, Lisa-Marie Mauracher, Lena Hell, Ingrid Pabinger, Marc A Bailey, D Julian A Scott, Lars Maegdefessel, Albert Busch, Ihor Huk, Christoph Neumayer, Christine Brostjan

Translational Research (Elsevier) Austria, UK, Sweden, 09 February 2021

Cardiology

Organism: Human

Tissue: Blood Vessels

Pathological State: Abdominal aortic aneurysms

634
IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer

G Jordakieva, R Bianchini, D Reichhold, J Piehslinger, A Groschopf, SA Jensen, E Mearini, G Nocentini, R Crevenna, GJ Zlabinger, SN Karagiannis, A Klaus, E Jensen-Jarolim

OncoImmunology (Taylor & Francis) Austria, Italy, UK, 08 February 2021

Oncology

Key words: IgG4, IgE, Tumor-Associated Macrophages, M2b, Allergooncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

635
Anti-inflammatory effects of Radix aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice

JH Liu, CH Hsieh, CY Liu, CW Chang, YJ Chen, TH Tsai

Journal of Ethnopharmacology (Elsevier) Taiwan, 07 February 2021

Pharmacology

Key words: 5-Fluorouracil (5-FU), Radix Aucklandiae, Intestinal Mucositis, Goblet Cell, Anti-Inflammatory

Organism: Mouse

Tissue: Small Intestine

Pathological State: Intestinal Mucositis

636
Hiltonol Cocktail Kills Lung Cancer Cells by Activating Cancer-Suppressors, PKR/OAS, and Restraining the Tumor Microenvironment

SC Chang, BX Zhang, ECY Su, WC Wu, TH Hsieh, AM Salazar, YK Lin, JL Ding

International Journal of Molecular Sciences (MDPI) Taiwan, USA, Singapore, 05 February 2021

Oncology

Key words: NSCLC (Non-Small Cell Lung Cancer), Combinatorial Treatment with Hiltonol+++ Cocktail [Hiltonol+Anti-IL6+Stattic+AG490], Tumorigenic Microenvironment, Anti- and Pro-Tumorigenic Cytokine Production, Tumor-Suppressors PKR (Protein Kinase R) And OAS (2′5′ Oligoadenylate Synthetase)

Organism: Human

Tissue: Lung

Pathological State: Cancer

637
H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice.

L Ruilian, Q Honglin, X Jun, L Jianxin, B Qingyun, C Yilin, M Haifeng

Journal of Affective Disorders (Elsevier) China, 05 February 2021

Neuroscience

Key words: Chronic Stress Stimulated Depression Model, Hippocampus, Hydrogen Sulfide, Inflammatory, Aerobic Exercise

Organism: Mouse

Tissue: Brain

638
Morphine acts on spinal dynorphin neurons to cause itch through disinhibition

E Nguyen, G Lim, H Ding, J Hachisuka, MC Ko, SE Ross

Science Translational Medicine (AAAS) USA, UK, 03 February 2021

Neuroscience

Organism: Mouse

Tissue: Skin

639
Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF

K Uranowska, T Kalic, V Valtsanidis, M Kitzwögerer, H Breiteneder, C Hafner

Oncology Reports (Spandidos Publications) Austria, 02 February 2021

Oncology

Organism: Human

Cell Line: Melanoma cells

640
Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer

J Yang, A Eresen, J Shangguan, Q Ma, V Yaghmai, Z Zhang

OncoImmunology (Taylor & Francis) USA, 02 February 2021

Oncology

Key words: Irreversible Electroporation, Dendritic Cell Vaccine, Pancreatic Ductal Adenocarcinoma, Magnetic Resonance Imaging

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

641
iTRAQ-based Quantitative Proteomic Analysis of Dural Tissues Reveals Upregulated Haptoglobin to be a Potential Biomarker of Moyamoya Disease

X Zhang, L Yin, X Jia, Y Zhang, T Liu, L Zhang

Current Proteomics (ingentaconnect) China, 01 February 2021

Proteomics

Key words: Moyamoya Disease, Dura Mater, Proteomics, iTRAQ, Haptoglobin, Strokes

642
Nerve Fibers in the Tumor Microenvironment Are Co-Localized with Lymphoid Aggregates in Pancreatic Cancer

LR Heij, X Tan, JN Kather, JM Niehues, S Sivakumar, N Heussen, G van der Kroft, SWM Olde Damink, S Lang, MR Aberle, T Luedde, NT Gaisa, J Bednarsch, DHW Liu, JPM Cleutjens, DP Modest, UP Neuman, GJ Wiltberger

Journal of Clinical Medicine (MDPI) Germany, The Netherlands, UK, Austria, 30 January 2021

Oncology

Key words: Tumor Microenvironment, Machine Learning, Nerve Fiber Density, Spatial Arrangements, Tertiary Lymphoid Structures, Pancreatic Cancer

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

643
Endothelial-Derived miR-17∼ 92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury

T Chiba, DM Cerqueira, Y Li, AJ Bodnar, E Mukherjee, K Pfister, YL Phua, K Shaikh, BT Sanders, SL Hemker, PJ Pagano, YL Wu, J Ho, S Sims-Lucas

Journal of The American Society of Nephrology (Am Soc Nephrol) USA, 29 January 2021

Nephrology

Key words: microRNA, Acute Kidney Injury, Renal Microvasculature

Pathological State: Acute Kidney Injury

644
Mer tyrosine kinase (MerTK) as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease

L Rovati, N Kaneko, F Pedica, A Monno, T Maehara, C Perugino, M Lanzillotta, S Pecetta, JH Stone, C Doglioni, AA Manfredi, S Pillai, E Della-Torre

Rheumatology (Oxford Academic) Italy, USA, Japan, 29 January 2021

Rheumatology

Key words: IgG4-Related Disease, Macrophages, MerTK, Protein S, Fibrosis

Organism: Human

Tissue: Submandibular Gland, Pancreas

Pathological State: IgG4-Related Disease

645
Effects of Nicorandil on Inflammation, Apoptosis and Atherosclerotic Plaque Progression

M Lenz, C Kaun, KA Krychtiuk, P Haider, M Brekalo, N Maier, L Goederle, CJ Binder, K Huber, C Hengstenberg, J Wojta, PJ Hohensinner, WS Speidl

Biomedicines (MDPI) Austria, 27 January 2021

Cardiology

Key words: Nicorandil, Inflammation, Apoptosis, Atherosclerosis, Plaque, Plaque Stabilization

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

646
Interleukin-24 protects against liver injury in mouse models

HH Wang, JH Huang, MH Sue, WC Ho, YH Hsu, KC Chang, MS Chang

EBioMedicine (THE LANCET) Taiwan, 25 January 2021

Hepathology

Key words: Interleukin-24, Liver Fibrosis, Thioacetamide-Induced Liver Injury, Hepatic Stellate Cells

Organism: Human

Tissue: Liver

Pathological State: Liver Fibrosis

647
Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model

CY Yeung, JSC Chiau, ML Cheng, WT Chan, SW Chang, CB Jiang, HC Lee

Gastroenterology Research and Practice (Hindawi Publishing Corporation) Taiwan, 25 January 2021

Gastroenterology

Organism: Mouse

Tissue: Small Intestine

Pathological State: Intestinal Mucositis

648
A Hepatitis B Virus-Derived Peptide Exerts an Anticancer Effect via TNF/iNOS-producing Dendritic Cells in Tumor-Bearing Mouse Model

SB Yang, MH Lee, BR Kim, YM Choi, BJ Kim

Cancers (MDPI) South Korea, 22 January 2021

Oncology

Key words: HBV-Derived Poly6 Peptide, TNF/ iNOS-Producing DCs (Tip-DCs), Type 1 Interferon (IFN-I), CD40, Cancer Immunotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

649
Androgen Plays a Carcinogenic Role in EOC via the PI3K/AKT Signaling Pathway in an AR-Dependent Manner

Y Li, S Li, Y Zhang, S Shi, S Qin, C Wang, J Du, J Ma, H Chen, H Cui

Journal of Cancer (Ivyspring International Publisher) China, 21 January 2021

Oncology

Key words: Ovarian Carcinoma, Androgen Receptor (AR), Tissue Microarray (TMA), Proliferation Promotion, PI3K/AKT Signalling Pathway

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

650
Performance and Meat Quality of Intrauterine Growth Restricted Pigs

P Matyba, T Florowski, K Dasiewicz, K Ferenc, J Olszewski, M Trela, G Galemba, M Słowiński, M Sady, D Domańska, Z Gajewski, R Zabielski

Animals (MDPI) Poland, 20 January 2021

Zoology

Key words: IUGR, Pigs, Growth Performance, Meat Quality, Sensory Evaluation

Organism: Pig

Tissue: Muscle

651
Pathological Pulmonary Vascular Remodeling is Induced by Type V Collagen in a Model of Scleroderma

RG Marangoni, BD Korman, ER Parra, APP Velosa, HV Barbeiro, V Martins, ABG dos Santos, F Soriano, WR Teodoro, PL Silva, W Tourtellotte, VL Capelozzi, J Varga, NH Yoshinari

Pathology-Research and Practice (Elsevier) Brazil, USA, 19 January 2021

Cardiology

Key words: Animal Model, Scleroderma, Collagen V, Vascular Disease, Endothelium

Organism: Rabbit

Tissue: Lung

Pathological State: Scleroderma, Vascular Disease

652
Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections

HY Park, SD Zoller, V Hegde, W Sheppard, Z Burke, G Blumstein, C Hamad, M Sprague, J Hoang, R Smith, FR Pastrana, J Czupryna, LS Miller, M López-Álvarez, M Bispo, M van Oosten, J Maarten van Dijl, KP Francis, NM Bernthal

Scientific Reports (Nature) USA, The Netherlands, 15 January 2021

Medical Imaging

Key words: Biofilms, Infectious Diseases

Pathological State: Staphylococcus aureus Infection

653
PEG-GO@ XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to …

J Zhang, L Yan, P Wei, R Zhou, C Hua, M Xiao, Y Tu, Z Gu, T Wei

European Journal of Pharmacology (Elsevier) China, USA, 14 January 2021

Oncology, Nanomedicine

Key words: Graphene Oxide, Xanthohumol, Breast Cancer Metastasis, Mitochondria, Epithelial-Mesenchymal Transition, Energy Metabolism

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

654
Macromolecular crowding as a tool to screen anti-fibrotic drugs: the Scar-in-a-Jar system revisited

NP Cavanzo, E Bigaeva, M Boersema, P Olinga, RA Bank

Frontiers in Medicine (Frontiers Media S.A.) The Netherlands, China, USA, Switzerland, 14 January 2021

Biological Methods

Key words: Macromolecular Crowding, Drug Testing, Fibrosis, Collagen, Myofibroblast

Organism: Human

Cell Line: adult primary human dermal fibroblasts

655
Mesenchymal stem cell‐glioblastoma interactions mediated via kinin receptors unveiled by cytometry

MM Pillat, Á Oliveira‐Giacomelli, M das Neves Oliveira, R Andrejew, N Turrini, J Baranova, TL Turnšek, H Ulrich

Cytometry Part A (Wiley) Brazil, 13 January 2021

Medical Image Analysis

Key words: Cytometry, Glioblastoma, Kinin Receptors, Kinin‐B1 Receptor, Kinin‐B2 Receptor, Mesenchymal Stem Cells

Organism: Human

Cell Line: Glioblastoma (U87) cells, Mesenchymal stem cell

656
Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition

YY Wang, B Zhao, MM Wu, XL Zheng, L Lin, DM Yin

Nature Communications (Nature) China, 12 January 2021

Neuroscience

Key words: Molecular Neuroscience, Schizophrenia

Organism: Mouse

Tissue: Brain

657
Stem Cell-Derived Respiratory Epithelial Cell Cultures as Human Disease Models

JC Orr, RE Hynds

American Journal of Respiratory Cell and Molecular Biology (Wiley) UK, 11 January 2021

Stem Cell Research

Key words: Respiratory Epithelium, Epithelial Cells, Cell Culture, Cloning, Stem Cells

658
Overexpression of GLUT3 promotes metastasis of triple‐negative breast cancer by modulating the inflammatory tumor microenvironment

TH Tsai, CC Yang, TC Kou, CE Yang, JZ Dai, CL Chen, CW Lin

Journal of Cellular Physiology (Wiley) Taiwan, 09 January 2021

Oncology

Key words: Glycolysis, Inflammation, Triple‐Negative Breast Cancer, Tumor Microenvironment, Tumor‐Associated Macrophage

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

659
Development and Validation of Sorafenib-eluting Microspheres to Enhance Therapeutic Efficacy of Transcatheter Arterial Chemoembolization in a Rat Model of of Hepatocellular Carcinoma

W Park, S Cho, J Ji, RJ Lewandowski, AC Larson, DH Kim

Radiology: Imaging Cancer (Royal Society of Chemistry) USA, 08 January 2021

Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

660
Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade

C Bangert, K Rindler, T Krausgruber, N Alkon, FM Thaler, H Kurz, T Ayub, D Demitras, N Fortelny, V Vorstandlechner, WM Bauer, T Quint, M Mildner, C Jonak, A Elbe-Bürger, J Griss, C Bock, PM Brunner

Science Immunology (Science) Austria, 08 January 2021

Immunology, Dermatology

Organism: Human

Tissue: Skin

Pathological State: Dermatitis

661
Differential expression of microRNA miR-150-5p in IgA nephropathy as a potential mediator and marker of disease progression.

IZA Pawluczyk, A Didangelos, SJ Barbour, L Er, JU Becker, R Martin, S Taylor, JS Bhachu, EG Lyons, R Jenkins, D Fraser, K Molyneux, J Perales-Paton, J Saez-Rodriguez, J Barratt

Kidney International (Elsevier) UK, Canada, Germany, Spain, 06 January 2021

Nephrology

Key words: IgA Nephropathy, microRNA

Organism: Human

Tissue: Kidney

Pathological State: IgA nephropathy

662
Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1

Z Liu, L Sun, Y Cai, S Shen, T Zhang, N Wang, G Wu, W Ma, ST Li, C Suo, Y Hao, WD Jia, GL Semenza, P Gao, H Zhang

Cancer Research (AACR Publications) China, USA, 05 January 2021

Oncology

663
Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation

Tolani F Olonisakin, Tomeka Suber, Shekina Gonzalez-Ferrer, Zeyu Xiong, Hernán F Peñaloza, Rick van der Geest, Yuting Xiong, David O Osei-Hwedieh, Jesús Tejero, Matthew R Rosengart, Wendy M Mars, Daria Van Tyne, Andreas Perlegas, Samuel Brashears, Daniel B Kim-Shapiro, Mark T Gladwin, Michael A Bachman, Eldad A Hod, Claudette St Croix, Yulia Y Tyurina, Valerian E Kagan, Rama K Mallampalli, Anuradha Ray, Prabir Ray, Janet S Lee

The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, 04 January 2021

Immunology

Organism: Mouse

Tissue: Liver

664
IN VITRO CHARACTERIZATION OF HYDROXYAPATITE-BASED BIOMATERIALS, USING MESENCHYMAL STEM CELL CULTURES FROM HUMAN BONE …

LE Sima, RM Varut, O Gingu, G Sima, C Teisanu, J Neamtu

Journal of Science and Arts (Josa.ro) Romania, 30 December 2020

Biological Materials

Key words: Hydroxyapatite, Calcium Fructoborate, Mesenchymal Stem Cell, Human Bone Marrow

Organism: Human

Cell Line: Mesenchymal stem cells

665
Persistent inhibition of Candida albicans biofilm and hyphae growth on titanium by graphene nanocoating

SV Agarwalla, K Ellepola, N Silikas, AHC Neto, C Jayampath, SV Rosa

Dental Materials (Elsevier) Singapore, USA, UK, 25 December 2020

Biological Materials

Key words: Implant, Surface Free Energy, Contact Angle, Topography, Microbial Attachment, Antiadhesive Coating, Peri-Implantitis

Cell Line: C. albicans

666
Obesity is associated with shorter telomere length in prostate stromal cells in men with aggressive prostate cancer

CE Joshu, CM Heaphy, JR Barber, J Lu, R Zarinshenas, C Davis, M Han, TL Lotan, KS Sfanos, AM De Marzo, AK Meeker, EA Platz

Cancer Prevention Research (AACR Publications) USA, 22 December 2020

Oncology

667
PD‐L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer

TJ Miller, CC Anyaegbu, TF Lee‐Pullen, LJ Spalding, CF Platell, MJ McCoy

Cancer Science (Wiley) Australia, 20 December 2020

Oncology

Key words: CD8, Colon Cancer, Dendritic Cells, PD‐L1, T Cells

668
Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma

T Tashiro, K Imamura, Y Tomita, D Tamanoi, A Takaki, K Sugahara, R Sato, K Saruwatari, S Sakata, M Inaba, S Ushijima, N Hirata, T Sakagami

International Journal of Molecular Sciences (MDPI) Japan, USA, 19 December 2020

Oncology

Key words: Anaplastic Lymphoma Kinase (ALK), B Cell, Heterogeneity, Immune Checkpoint, Large Cell Neuroendocrine Carcinoma (LCNEC), Neuroendocrine Tumors (NET), Regulatory T-Cells (Tregs), Programmed Death-Ligand 1 (PD-L1), Tumor-Infiltrating Lymphocyte (TIL), Tumor-Immune Microenvironments (TIME)

Organism: Human

Tissue: Lung

Pathological State: Cancer

669
Parp1-Dependent DNA Double-Strand Break Repair in Irradiated Late Pachytene Spermatocytes

E A Ahmed, A M Alzahrani, H Scherthan

DNA and Cell Biology (Mary Ann Liebert Inc.) Saudi Arabia, Egypt, Germany, 18 December 2020

Reproductive Medicine

Key words: Alternative NHEJ, DNA Repair, First Meiotic Prophase, γ-H2AX, Homologous Recombination, Parp1, Spermatogenesis

Organism: Human

Cell Line: Spermatocytes

670
Differential mast cell phenotypes in benign versus cancer tissues and prostate cancer oncologic outcomes

H Hempel Sullivan, JP Maynard, CM Heaphy, J Lu, AM De Marzo, TL Lotan, CE Joshu, KS Sfanos

The Journal of Pathology (Wiley) USA, 18 December 2020

Oncology

Key words: Prostate Cancer, Mast Cells, Metastases, CXCR4, TFE3, KIT, Microenvironment

Organism: Human

Tissue: Prostate

Pathological State: Cancer

671
ZFHX3 Knockdown Dysregulates Mitochondrial Adaptations to Tachypacing in Atrial Myocytes through Enhanced Oxidative Stress and Calcium Overload

B Lkhagva, YK Lin, YC Chen, WL Cheng, S Higa, YH

Acta Physiologica (Wiley) Taiwan, Japan, 17 December 2020

Physiology

Key words: Atrial Fibrillation, Calcium, Mitochondria, Tachypacing, ZFHX3

Organism: Human

Cell Line: HL‐1 cells

672
CD4+ CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum

H Allard-Chamard, F Alsufyani, N Kaneko, K Xing, C Perugino, VS Mahajan, JL Wheat, GS Deepe Jr, J Loyd and S Pillai

The Journal of Immunology (American Association of Immunologists) Canada, Saudi Arabia, Japan, USA, 16 December 2020

Immunology

Organism: Human

Tissue: Mediastinum

Pathological State: Mediastinitis

673
Tribbles Pseudokinase 3 Contributes to Cancer Stemness of Endometrial Cancer Cells by Regulating β-Catenin Expression

WL Wang, GC Hong, PJ Chien, YH Huang, HT Lee, PH Wang, YC Lee, WW Chang

Cancers (MDPI) Taiwan, 15 December 2020

Oncology

Key words: Tribbles Pseudokinase 3, Endometrial Cancer, Cancer Stem Cells, β-Catenin, Epithelial–Mesenchymal Transition

Organism: Human

Cell Line: Endometrial Cancer Cell Lines (AN3CA and HEC1A)

674
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

TJ Hark, NR Rao, C Castillon, T Basta, S Smukowski, H Bao, A Upadhyay, E Bomba-Warczak, T Nomura, ET O'Toole, GP Morgan, L Ali, T Saito, C Guillermier, TC Saido, ML Steinhauser, MHB Stowell, ER Chapman, A Contractor, JN Savas

Cell Systems (Cell Press) USA, Japan, 15 December 2020

Neuroscience

Key words: Alzheimer's Diseasea, Myloid Beta, Synaptic Dysfunction, Presynapse, Synaptic Vesicles, Proteostasis, Mass Spectrometry, Proteomics, APP Knockin Mice

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

675
Multicohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors

K Ando, A Ozonoff, SY Lee, M Viosine, JT Parker, R Nakanishi, S Nishimura, J Yang, Z Grace, B Tran, TJ Diefenbach, Y Maehara, H Yasui, T Irino, R Salgia, M Terashima, P Gibbs, RK Ramanathan, E Oki, M Mori, M Kulke, K Hartshorn, A Bharti

Clinical Colorectal Cancer (Elsevier) USA, Japan, Australia, 10 December 2020

Oncology

Organism: Human

Tissue: Stomach

Pathological State: Cancer

676
Spatiotemporal Up-Regulation of Mu Opioid Receptor 1 in Striatum of Mouse Model of Huntington's Disease Differentially Affecting Caudal and Striosomal Regions

R Morigaki, JH Lee, T Yoshida, C Wüthrich, D Hu, JR Crittenden, A Friedman, Y Kubota, AM Graybiel

Frontiers in Neuroanatomy (Frontiers Media S.A.) USA, Japan, 10 December 2020

Neuroscience

Key words: Mu Opioid Receptors, Huntington’s Disease, Neostriatum, Movement Disorders, Mood Disorders, Animal Models of Human Disorders, Striosome

Organism: Mouse

Tissue: Brain

Pathological State: Huntington's Disease

677
Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro

L Elena Sima, A Bonciu, M Baciu, I Anghel, LN Dumitrescu, L Rusen, V Dinca

Nanomaterials (MDPI) Romania, 09 December 2020

Nanomedicine

Key words: Zirconia, Mesenchymal Stem Cells, Micro-Nano Topography, Osteogenic Differentiation, Bone-Anchored Hearing Aid (BAHA)

Organism: Human

Cell Line: hMSCs

678
The effect of dietary supplementation with high-or low-dose omega-3 fatty acid on inflammatory pathology after traumatic brain injury in rats

EK Black, JK Phillips, J Seminetta, J Bailes, JM Lee, JD Finan

Translational Neuroscience (degruyter) USA, 09 December 2020

Neuroscience

Key words: Dietary Supplementation, Docosahexanoic Acid, Eicosapentaenoic Acid, Neuroinflammation, Neuroprotection, Omega-3 Fatty Acid, Traumatic Brain Injury

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

679
Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis

W Kang, Q Wang, Y Dai, H Wang, M Wang, J Wang, D Zhang, P Sun, T Qi, X Jin, Z Cui

Cell Death & Disease (Nature) China, 07 December 2020

Oncology

Key words: Bladder Cancer, Long Non-Coding RNAs, Oncogenesis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

680
Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients

H Wang, C Feng, M Lu, B Zhang, Y Xu, Q Zeng, J Xi, J Zhou, X Ying, J Zhang, W Yue, X Pei

Translational Oncology (Elsevier) China, 06 December 2020

Oncology

Key words: Liver Cancer, Single-Cell Transcriptome, Cancer-Distinct Fibroblast, SPARCL1

Organism: Human

Tissue: Liver

Pathological State: Cancer

681
Lactic acidosis interferes with toxicity of perifosine to colorectal cancer spheroids: multimodal imaging analysis

B Pavlatovská, M Machálková, P Brisudová, A Pruška, K Štěpka, J Michálek, T Nečasová, P Beneš, J Šmarda, J Preisler, M Kozubek, J Navrátilová

Frontiers in Oncology (Frontiers Media S.A.) Czech Republic, Switzerland, China, 04 December 2020

Oncology

Key words: Perifosine, Akt Kinase, Tumor Environment, Lactic Acidosis, Alkalization, Signal Co-Registration, Mass Spectrometry Imaging, Colorectal Cancer

Organism: Human

Cell Line: HT-29 and HCT-116 cells

682
AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

G Caluori, E Odehnalova, T Jadczyk, M Pesl, I Pavlova, L Valikova, S Holzinger, V Novotna, V Rotrekl, A Hampl, M Crha, D Cervinka, Z Starek

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) Czech Republic, France, Poland, Germany, 03 December 2020

Cardiology

Key words: Pulsed Field Ablation, Irreversible Electroporation (IRE), Radiofrequency Ablation, Atrial Fibrillation, Ventricular Arrhythmia (VA), Preclinical Cardiology

Organism: Pig

Tissue: Heart

683
Shear stress-exposed pulmonary artery endothelial cells fail to upregulate HSP70 in chronic thromboembolic pulmonary hypertension

W Salibe-Filho, TLS Araujo, EG Melo, LBCT Coimbra, MS Lapa, MMP Acencio, O Freitas-Filho, VL Capelozzi, LR Teixeira, CJCS Fernandes, F Biscegli Jatene, FRM Laurindo, M Terra-Filho

PLoS One (PLOS) Brazil, 03 December 2020

Cardiology

Key words: Shear Stresses, Endothelial Cells, Heat Shock Response, Pulmonary Arteries, Peas, Flow Cytometry, Nitric Oxide, Pulmonary Hypertension

Organism: Human

Pathological State: Pulmonary hypertension

Cell Line: HPAECs

684
Infiltration of metastatic lymph nodes with PD-1+ T cells is associated with improved disease-free and overall survival in resected N+ NSCLC

S Wang, Y Song, MA Morse, P Sun, G Qiao, X Wang, X Zhou, A Hobeika, J Ren, HK Lyerly

American Journal of Cancer Research (e-Century Publishing Corporation) China, USA, 01 December 2020

Oncology

Key words: NSCLC, Metastatic Lymph Node, T Cell Subsets, PD-1, TIM-3

Organism: Human

Tissue: Lung

Pathological State: Cancer

685
The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients

G Spanier, I Ugele, F Nieberle, L Symeou, S Schmidhofer, A Brand, J Meier, S Spoerl, R Krupar, P Rümmele, P Siska, K Renner, K Peter, M Gerken, P Beckhove, TE Reichert, M Kreutz, K Singer

Cancer Letters (Elsevier) Germany, 01 December 2020

Oncology

Key words: OSCC, Diabetes Mellitus, TIL, Metabolism, Prognosis

Organism: Human

Pathological State: Cancer

686
p21‐activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1

H Huang, Q Xue, X Du, J Cui, J Wang, D Cheng, J Li, Y Zheng, G Huang, K Zhang, K Liu, J Lu, J Zhao, X Chen, Z Dong, X Li

Molecular Carcinogenesis (Wiley) China, 01 December 2020

Oncology

Key words: Cell Proliferation, Esophageal Squamous Cell Carcinoma, LASP1, Metastasis, PAK4

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

687
Cross-Reactive Effects of Vaccines: Heterologous Immunity between Tetanus and Chlamydia

M Stojanovic, I Lukic, E Marinkovic, A Kovacevic, R Miljkovic, J Tobias, I Schabussova, M Zlatovic, T Barisani-Asenbauer, U Wiedermann, A Inic-Kanada

Vaccines (MDPI) Serbia, Austria, 01 December 2020

Immunology

Key words: Vaccination, Heterologous Immunity, Antibodies, Tetanus, Chlamydia, Cross-Reactivity

Organism: Human

Cell Line: Human conjunctival epithelial cell line

688
Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats

W Wang, X Liu, Z Yang, H Shen, L Liu, Y Yu, T Zhang

Frontiers in Neuroscience (Frontiers Media S.A.) China, 30 November 2020

Neuroscience

Key words: Levodopa, Hippocampus, Global Cerebral Ischemia Reperfusion Injury, Structural Synaptic Plasticity, Cognitive Function

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

689
Characterization of epithelial cells, connective tissue cells and immune cells in human upper airway mucosa by immunofluorescence multichannel image cytometry: a pilot study

AI Giotakis, J Dudas, R Glueckert, D Dejaco, J Ingruber, F Fleischer, V innerhofer, L Pinggera, L Bektic-Tadic, SAM Gabriel, H Riechelmann

Histochemistry and Cell Biology (Springer) Austria, 29 November 2020

Medical Image Analysis

Key words: Image Cytometry, Fluorescent Antibody Technique, Immunohistochemistry, Nasal Mucosa, Sinusitis

Organism: Human

Tissue: Mucosa

Pathological State: Chronic Rhinosinusitis

690
MicroRNA-146a suppresses tumor malignancy via targeting vimentin in esophageal squamous cell carcinoma cells with lower fibronectin membrane assembly

HY Chang, CH Lee, YS Li, JT Huang, SH Lan, YF Wang, WW Lai, YC Wang, YJ Lin, HS Liu, HC Cheng

Journal of Biomedical Science (BMC) Taiwan, 28 November 2020

Oncology

Key words: ESCC, MiR-146a, Vimentin, Cell Migration, Invasion

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

691
Lactobacillus Attenuate the Progression of Pancreatic Cancer Promoted by Porphyromonas Gingivalis in K-rasG12D Transgenic Mice

SM Chen, LJ Hsu, HL Lee, CP Lin, SW Huang, CJL Lai, CW Lin, WT Chen, YJ Chen, YC Lin, CC Yang, MS Jan

Cancers (MDPI) Taiwan, 26 November 2020

Oncology

Key words: Caerulein, Lactobacillus, Pancreatic Ductal Adenocarcinoma, Porphyromonas Gingivalis, Transforming Growth Factor-β

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

692
Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages

YY Wang, HD Chen, S Lo, YK Chen, YC Huang, S CS Hu, YC Hsieh, AC Hung, MF Hou, SS F Yuan

Cancers (MDPI) Taiwan, UK, 26 November 2020

Oncology

Key words: Visfatin, Breast Cancer, Tumor-Associated Macrophages, CXCL1

Organism: Human

Tissue: Breast

Pathological State: Cancer

693
Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice

K Han, X Jin, X Guo, G Cao, S Tian, Y Song, Y Zuo, P Yu, G Gao, YZ Chang

Free Radical Biology and Medicine (Elsevier) China, 26 November 2020

Neuroscience

Key words: Nrf2, Motor Dysfunction, Brain Iron Metabolism, Oxidative Stress, FPN1

Organism: Mouse

Tissue: Brain

694
Neuropathology changed by 3-and 6-months low-level PM 2.5 inhalation exposure in spontaneously hypertensive rats

HC Chuang, HC Chen, PJ Chai, HT Liao, CF Wu, CL Chen, MK Jhan, HI Hsieh, KY Wu, TF Chen, TJ Cheng

Particle and Fibre Toxicology (Springer) Taiwan, 26 November 2020

Neuroscience

Key words: Air Pollution, Autophagy, Central Nervous System Toxicity, Particulate Matter, Tau

Organism: Rat

Tissue: Brain

695
Electric Pulse Responsive Magnetic Nanoclusters Loaded with Indoleamine 2, 3-Dioxygenase Inhibitor for Synergistic Immuno-Ablation Cancer Therapy

B Yu, W Zhang, K Kwak, H Choi, DH Kim

ACS Applied Materials & Interfaces (ACS Publications) USA, 25 November 2020

Oncology

Key words: Local Ablation, Irreversible Electroporation, Indoleamine 2, 3-Dioxygenase Inhibitor, Magnetic Nanoparticles, Immunotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

696
Development of Rift valley fever encephalitis in rats is mediated by early infection of olfactory epithelium and neuroinvasion across the cribriform plate

DA Boyles, MM Schwarz, JR Albe, CM Mcmillen, KJ O'Malley, DS Reed, AL Hartman

Journal of General Virology (Microbiology Society) USA, 24 November 2020

Virology

Key words: Aerosol, Cribriform Plate, Encephalitis, Olfactory Bulb, Pathogenesis, Rift Valley Fever Virus

Organism: Rat

Tissue: Mucosa

Pathological State: Encephalitis

697
Time-resolved analysis of Staphylococcus aureus invading the endothelial barrier

EJM Raineri, H Yedavally, A Salvati, JM van Dijl

Virulence (Taylor & Francis) The Netherlands, 22 November 2020

Microbiology

Key words: Staphylococcus Aureus, MRSA, Endothelium, Invasion, Intracellular

Organism: Human

Cell Line: HUVECs

698
Type II natural killer T cells contribute to protection against systemic methicillin-resistant Staphylococcus aureus infection

S Genardi, L Visvabharathy, L Cao, E Morgun, Y Cui, C Qi, YH Chen, L Gapin, E Berdyshev, CR Wang

Frontiers in Immunology (Frontiers Media S.A.) USA, 18 November 2020

Immunology

Key words: Staphylococcus Aureus, Natural Killer T Cells, CD1, Lipid Antigens, Cytokine, Knockout Mice

Organism: Mouse

Tissue: Kidney

Pathological State: Staphylococcus aureus Infection

699
Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease

J Strobl, RV Pandey, T Krausgruber, N Bayer, L Kleissl, B Reininger, P Vieyra-Garcia, P Wolf, MM Jentus, M Mitterbauer, W Rabitsch, G Stingl, C Bock, G Stray

Science Translational Medicine (AAAS) Austria, 18 November 2020

Dermatology

Organism: Human

Tissue: Skin

Pathological State: Graft-versus-host disease

700
Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

A Li, Y Ling, Z Song, X Cheng, L Ding, R Jiang, W Fu, Y Liu, H Hu, S Yuan, J Chen, C Zhu, J Fan, J Wang, Y Jin, M Zhang, L Zhu, P Sun, L Zhang, R Qin, W Zhang, C Qiu, Y Shen, L Zhang, Z Shi, C Zhao, T Zhu, H Lu, H Zhang, J Xu

The Journal of Infectious Diseases (Oxford Academic) China, 17 November 2020

SARS-CoV-2

Key words: IL-37, SARS-CoV-2, COVID-19, Inflammation, Clinical Outcomes

Organism: Mouse

Tissue: Lung

Pathological State: COVID-19

701
Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model

A Ramírez-Fernández, L Urbina-Treviño, G Conte, M Alves, B Rissiek, A Durner, N Scalbert, J Zhang, T Magnus, F Koch-Nolte, N Plesnila, JM Deussing, T Engel, R Kopp, A Nicke

Scientific Reports (Nature) Germany, Ireland, 16 November 2020

Neuroscience

Key words: Biological Techniques, Molecular Biology, Neuroscience

Organism: Mouse

Tissue: Brain

702
HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age‐dependent changes

M Luque, A Schrott‐Fischer, J Dudas, E Pechriggl, E Brenner, H Rask-Andersen, W Liu, R Glueckert

Journal of Neuroscience Research (Wiley) Austria, 12 November 2020

Neuroscience

Key words: Auditory Development, Auditory Neuron Diversity, Axon Initial Segment, HCN Channels, Prestin, RRID:AB_90725, RRID:AB_2039906, RRID:AB_2302038, RRID:AB_2313584, RRID:AB_2313726, RRID:AB_2336419, RRID:AB_2336420, RRID:AB_2336790, RRID:AB_2340477, RRID:AB_2340452, RRID:AB_2340593, RRID:AB_2341028, RRID:AB_2617143, RRID:AB_2756625, RRID:AB_2756742, RRID:SCR_002865, RRID:SCR_013652, RRID:SCR_014823, Sound Coding, Spiral Ganglion Neurons, Voltage Gated

Organism: Mouse, Human

703
Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

M Hara-Chikuma, M Tanaka, AS Verkman, M Yasui

Nature Communications (Nature) Japan, USA, 09 November 2020

Hepathology

Key words: Molecular Drug Discovery, Liver Diseases, Molecular Medicine

Organism: Mouse

Tissue: Bone Marrow

Pathological State: Liver Injury

704
CO2-Responsive Water-Soluble Conjugated Polymers for In Vitro and In Vivo Biological Imaging

CC Cheng, YC Lai, YT Shieh, YH Chang, AW Lee, JK Chen, DJ Lee, JY Lai

Biomacromolecules (ACS Publications) Taiwan, 06 November 2020

Medical Imaging

Organism: Zebrafish

Tissue: Whole Organism

705
Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19

Y Liu, J Lv, J Liu, M Li, J Xie, Q Lv, W Deng, N Zhou, Y Zhou, J Song, P Wang, C Qin, WM Tong, B Huang

Cell Research (Nature) China, 06 November 2020

Immunology, SARS-CoV-2

Key words: Immunology, Innate Immunity

Organism: Mouse

Tissue: Lung

Pathological State: Covid-19

706
Evidence for a non-stochastic two-field hypothesis for persistent skin cancer risk

RL Konger, L Ren, RP Sahu, E Derr-Yellin, YL Kim

Scientific Reports (Nature) USA, 05 November 2020

Oncology

Key words: Cancer Microenvironment, Cancer Models, Skin Cancer, Squamous Cell Carcinoma

Organism: Mouse

Tissue: Skin

Pathological State: Cancer

707
Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14

R Widhalm, I Ellinger, S Granitzer, M Forsthuber, R Bajtela, K Gelles, PY Hartig, M Hengstschläger, H Zeisler, H Salzer, C Gundacker

Metallomics (Royal Society of Chemistry) Austria, 04 November 2020

Reproductive Medicine

Organism: Human

Tissue: Placenta

708
Metformin chlorination byproducts in drinking water exhibit marked toxicities of a potential health concern

R Zhang, Y He, L Yao, J Chen, S Zhu, X Rao, P Tang, J You, G Hua, L Zhang, F Ju, L Wu

Environment International (Elsevier) China, 03 November 2020

Toxicology

Key words: Metformin, Metformin Chlorination Byproduct, Drinking Water, Toxicity, Public Health

Organism: Mouse

Tissue: Small Intestine

709
Effect of route of administration on the efficacy of dendritic cell vaccine in PDAC mice

J Yang, A Eresen, J Shangguan, Q Ma, Z Zhang, V Yaghmai

American Journal of Cancer Research (e-Century Publishing Corporation) USA, 01 November 2020

Oncology

Key words: Pancreatic Cancer, Dendritic Cell, Route of Administration

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

710
Therapeutic Efficacy of GC1118, a Novel Anti-EGFR Antibody, against Glioblastoma with High EGFR Amplification in Patient-Derived Xenografts

K Lee, H Koo, Y Kim, D Kim, E Son, H Yang, Y Lim, M Hur, H Won Lee, S Won Choi, DH Nam

Cancers (MDPI) South Korea, 31 October 2020

Oncology

Key words: Glioblastoma, Epidermal Growth Factor Receptor, Monoclonal, Xenograft, Amplification

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

711
P2Y2 receptor activation promotes esophageal cancer cells proliferation via ERK1/2 pathway

A Zaparte, AR Cappellari, CA Brandão, JB de Souza, TJ Borges, LW Kist, MR Bogo, LF Zerbini, LF Ribeiro Pinto, T Glaser, MCB Goncalves, Y Naaldijk, H Ulrich, FB Morrone

European Journal of Pharmacology (Elsevier) Brazil, USA, South Africa, 31 October 2020

Oncology

Key words: Esophageal Cancer, Purinergic System, Nucleotide, P2Y2R, Proliferation, Signaling Pathways

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

712
Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia–reperfusion injury

R Wang, M Wang, J Zhou, Z Dai, G Sun, X Sun

Journal of Advanced Research (Elsevier) China, 31 October 2020

Cardiology

Key words: Calenduloside E, Myocardial Ischemia-Reperfusion Injury, L-Type Calcium Channelscalcium Overload, Bcl2-Associated Athanogene 3

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

713
B Cell Activating Factor (BAFF) Is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats

L Steines, H Poth, M Herrmann, A Schuster, B Banas, T Bergler

International Journal of Molecular Sciences (MDPI) Germany, 28 October 2020

Nephrology

Key words: Tertiary Lymphoid Organs, Kidney Transplantation, B Cells, BAFF

Organism: Rat

Tissue: Kidney

Pathological State: Organ Transplantation

714
Proteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model

RM Boteanu, VI Suica, L Ivan, F Safciuc, E Uyy, E Dragan, SM Croitoru, V Grumezescu, M Chiritoiu, LE Sima, C Vlagioiu, G Socol, F Antohe

Scientific Reports (Nature) Romania, 28 October 2020

Osteology

Key words: Bioinformatics, Biological Models, Fracture Repair, Immunological Techniques, Mass Spectrometry, Microscopy, Proteomic Analysis

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

715
Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma

PL Yarova, P Huang, MW Schepelmann, R Bruce, R Ecker, R Nica, V Telezhkin, D Traini, L Gomes dos Reis, EJ Kidd, WR Ford, KJ Broadley, BM Kariuki, CJ Corrigan, JPT Ward, PJ Kemp, D Riccardi

The Journal of Pharmacology and Experimental Therapeutics (ASPET) UK, Austria, Australia, 28 October 2020

Pharmacology

Organism: Mouse

Tissue: Lung

716
Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model

A Friedman, E Hueske, SM Drammis, SET Arana, ED Nelson, CW Carter, S Delcasso, RX Rodriguez, H Lutwak, KS DiMarco, Q Zhang, LI Rakocevic, D Hu, JK Xiong, J Zhao, LG Gibb, T Yoshida, CA Siciliano, TJ Diefenbach, C Ramakrishnan, K Deisseroth, AM Graybiel

CELL (Cell Press) USA, 27 October 2020

Neuroscience

Key words: Corticostriatal, Approach-Avoidance, Cost-Benefit, Decision-Making, Utility, Subjective Value, Motivation, Parvalbumin Interneurons, VGluT1, Excitation-Inhibition Balance

Organism: Mouse

Tissue: Brain

Pathological State: Huntington's Disease

717
The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer

F Mungenast, A Meshcheryakova, A Beer, M Salzmann, D Tamandl, T Gruenberger, P Pietschmann, O Koperek, P Birner, I Kirsch, H Robins, M Mittlboeck, M Jaritz, M Bergmann, P Zimmermann, D Mechtcheriakova

Cancers (MDPI) Austria, Switzerland, 25 October 2020

Oncology

Key words: Lymphoid Structures,  Colonic Mucosa,  Metastatic Colorectal Cancer,  Immuno-Oncology,  B Lymphocytes,  Germinal Center,  Tissue Image Cytometry,  B-Cell Clonality,  Compendium-Wide Analysis,  Patient Stratification Strategy

Organism: Human

Tissue: Colon

Pathological State: Cancer

718
Cross‐section modified and highly elastic sutures reduce tissue incision and show comparable biocompatibility: in‐vitro and in‐vivo evaluation of novel thermoplastic urethane surgical threads

M Helmedag, D Heise, R Eickhoff, KM Kossel, T Gries, S Jockenhoevel, UP Neumann, CD Klink, A Lambertz

Journal of Biomedical Materials Research: Part B (Wiley) Germany, 24 October 2020

Tissue Engineering

Key words: Animal Trials, Biocompatibility, Elastic Sutures, Surface Modified Surgical Threads, Thermoplastic Polyurethane, Tissue Incision

Organism: Rat

Tissue: Stomach

719
Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

N Jacob, K Kumagai, JP Abraham, Y Shimodaira, Y Ye, J Luu, AY Blackwood, SL Castanon, DT Stamps, LS Thomas, R Gonsky, DQ Shih, KS Michelsen, SR Targan

Scientific Reports (Nature) USA, 23 October 2020

Immunology, Gastroenterology

Key words: Cytokines, Gastroenterology, Immunology, Inflammation, Inflammatory Bowel Disease

Organism: Mouse

Cell Line: Mouse primary colonic fibroblasts

720
Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma

A Makarevic, C Rapp, S Dettling, D Reuss, C Jungk, A Abdollahi, A van Deimling, A Unterberg, C Herold-Mende, R Warta

International Journal of Molecular Sciences (MDPI) Germany, 21 October 2020

Neuroscience

Key words: Lower-Grade Glioma, T-Cell Infiltration, TissueFAXS, Primary Tumors, Recurrent Tumors, Radiotherapy

Organism: Human

Tissue: Brain

Pathological State: Cancer

721
Impaired autophagy increases susceptibility to endotoxin-induced chronic pancreatitis

L Xia, Z Xu, X Zhou, F Bergmann, N Grabe, MW Büchler, JP Neoptolemos, T Hackert, G Kroemer, F Fortunato

Cell Death & Disease (Nature) Germany, 21 October 2020

Gastroenterology

Key words: Acute Pancreatitis, Chronic Pancreatitis

Organism: Mouse

Tissue: Pancreas

Pathological State: Pancreatitis

722
Tissue remodeling macrophages morphologically dominate at the interface of polypropylene surgical meshes in the human abdomen

A Dievernich, P Achenbach, L Davies, U Klinge

Hernia (Springer) Germany, UK, 18 October 2020

Tissue Engineering

Key words: Foreign Body Reaction, Macrophage, Collagen, Mesh, Fluorescence Microscopy

Organism: Mouse

Tissue: Stomach

723
CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy

Y Bei, N Cheng, T Chen, Y Shu, Y Yang, N Yang, X Zhou, B Liu, J Wie, Q Liu, W Zheng, W Zhang, H Su, WG Zhu, J Ji, P Shen

Advanced Science (Wiley) China, 15 October 2020

Oncology

Key words: Cancer Stem Cells, CD44 Variants, CDK5, Immune Checkpoint Blockade, PPARγ Phosphorylation, Triple‐Negative Breast Cancer, Tumor Microenvironment

Organism: Human

Tissue: Breast

Pathological State: Cancer

724
Poly (ADP-ribose) polymerase inhibitor treatment as a novel therapy attenuating renal ischemia-reperfusion injury

HR Jang, K Lee, J Jeon, JR Kim, JE Lee, GY Kwon, YG Kim, DJ Kim, JW Ko, W Huh

Frontiers in Immunology (Frontiers Media S.A.) South Korea, Italy, France, 14 October 2020

Immunology

Key words: Acute Kidney Injury, Ischemia-Reperfusion Injury, Poly(ADP-Ribose) Polymerase (PARP) Inhibitor, Parthanatos, Inflammation, Translational Immunology

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

725
Two Polyurethane Adhesives for PVDF Fixation Show Superior Biocompatibility in a Rat Model

D Heise, Y Mirlas, M Helmedag, R Eickhoff, A Kroh, A Lambertz, CD Klink, UP Neumann, U Klinge, R Tolba

Journal of Investigative Surgery (Taylor & Francis) Germany, The Netherlands, 14 October 2020

Tissue Engineering

Key words: Mesh Fixation, Polyurethane Adhesive, Incisional Hernia

Organism: Rat

Tissue: Stomach

726
FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

L Qiu, L Hu, H Wang, J Li, X Ruan, B Sun, J Zhi, X Zheng, L Gu, M Gao, P Kong, J Zhang

Cell Death & Disease (Nature) China, 09 October 2020

Oncology

Key words: Apoptosis, Macroautophagy

Organism: Human

Cell Line: Human NSCLC cell lines (A549, H520, H358, H460, H1299 and U87)

727
Immune contexture analysis in immuno‐oncology: applications and challenges of multiplex fluorescent immunohistochemistry

R Shakya, TH Nguyen, N Waterhouse, R Khanna

Clinical & Translational Immunology (Wiley) Australia, 07 October 2020

Immunology

Key words: FCS Express Image Cytometry, Immune Profiling, Multiplexed Fluorescent Immunohistochemistry, Quantitative Digital Pathology, Tumor Microenvironment, Vectra

728
Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring: role for AREG-induced EGFR signaling

K Lkhagvadorj, Z Zeng, J Song, M Reinders-Luinge, W Kooistra, S Song, S Krauss-Etschmann, BN Melgert, J Cao, MN Hylkema

APSselect (American Physiological Society) The Netherlands, Mongolia, Germany, China, 06 October 2020

Pulmonology

Key words: Amphiregulin, Epithelial Cell Differentiation, Lung Organoids, Prenatal Smoke Exposure

Organism: Mouse

Tissue: Lung

729
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency

M Werner-Klein, A Grujovic, C Irlbeck, M Obradović, M Hoffmann, H Koerkel-Qu, X Lu, S Treitschke, C Köstler, C Botteron, K Weidele, C Werno, B Polzer, S Kirsch, M Gužvić, J Warfsmann, K Honarnejad, Z Czyz, G Feliciello, I Blochberger, S Grunewald, E Schneider, G Haunschild, N Patwary, S Guetter, S Huber, B Rack, N Harbeck, S Buchholz, P Rümmele, N Heine, S Rose-John, CA Klein

Nature Communications (Nature) Germany, Switzerland, 05 October 2020

Oncology

Key words: Breast Cancer, Cancer

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

730
Innovations present in the primate interneuron repertoire

FM Krienen, M Goldman, Q Zhang, RCH del Rosario, M Florio, R Machold, A Saunders, K Levandowski, H Zaniewski, B Schuman, C Wu, A Lutservitz, CD Mullally, N Reed, E Bien, L Bortolin, M Fernandez-Otero, JD Lin, A Wysoker, J Nemesh, D Kulp, M Burns, V Tkachev, R Smith, CA Walsh, J Dimidschstein, B Rudy, LS Kean, S Berretta, G Fishell, G Feng, SA McCarroll

Nature (Nature) USA, 30 September 2020

Neuroscience

Key words: Evolutionary Biology, Genetics of The Nervous System, Transcriptomics

Organism: Marmoset

Tissue: Brain

731
Peptide-Based TNF-α-Binding Decoy Therapy Mitigates Lipopolysaccharide-Induced Liver Injury in Mice

CY Chang, HJ Hsu, J Foo, HJ Shih, CJ Huang

Pharmaceuticals (MDPI) Taiwan, 29 September 2020

Hepathology

Key words: TNF-α, Necroptosis, Pyroptosis, Apoptosis, Autophagy, Mitochondrial Injury

Organism: Mouse

Tissue: Liver

732
Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes

HT Wu, L Kang, YC Su, HY Ou, FY Chan, BH Su, YS Wang, CL Wu, AL Shiau, P Wu

Clinical Science (Portland Press) Taiwan, UK, 25 September 2020

Endocrinology

Key words: Fibrosis, Gestational Diabetes, Placenta, Prothymosin α, Trophoblast

Pathological State: Gestational Diabetes

733
A Systemic Prime–Intrarectal Pull Strategy Raises Rectum-Resident CD8+ T Cells for Effective Protection in a Murine Model of LM-OVA Infection

Q He, L Jiang, K Cao, L Zhang, X Xie, S Zhang, X Ding, Y He, M Zhang, C Zhao, X Zhang, J Xu

Frontiers in Immunology (Frontiers Media S.A.) China, 24 September 2020

Immunology

Key words: Mucosal Immune Response, Rectum TRM, Prime–Pull Vaccination Strategy, HIV, Listeria Monocytogenes

Organism: Mouse

Tissue: Lung

734
Discoidin Domain Receptors 1 Inhibition Alleviates Osteoarthritis via Enhancing Autophagy

HC Chou, CH Chen, LY Chou, TL Cheng, L Kang, SC Chuang, YS Lin, ML Ho, YH Wang, SY Lin, CZ Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 23 September 2020

Rheumatology

Key words: Discoidin Domain Receptors 1 (Ddr1), Osteoarthritis (OA), Autophagy, Apoptosis, Terminal Differentiation

Organism: Mouse

Tissue: Bone

Pathological State: Osteoarthritis

735
Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury

X Zhang, Y Jing, C Qin, C Liu, D Yang, F Gao, M Yang, L Du, J Li

Journal of Cellular and Molecular Medicine (Wiley) China, 17 September 2020

Neuroscience

Key words: Apoptosis, Autophagic Flux, Decompression, Mechanical Stress, mTOR, Spinal Cord Injury

Organism: Rabbit

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

736
Two common polymorphic variants of OATP4A1 as potential risk factors for colorectal cancer

V Buxhofer‑Ausch, O Német, M Sheikh, H Andrikovics, A Reiner, C Ausch, D Mechtcheriakova, A Tordai, A Gleiss, C Özvegy‑laczka, W Jäger, T Thalhammer

Oncology Letters (Spandidos Publications) Austria, Hungary, 17 September 2020

Oncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

737
Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins through BIP

J Chen, Z Chen, M Liu, T Qiu, D Feng, C Zhao, S Zhang, X Zhang, J Xu

mBio (American Society for Microbiolgy) China, 15 September 2020

Virology

Key words: BIP, Placental Alkaline Phosphatase, Zika Virus, Placental Trophoblast Cells

Organism: Human

Cell Line: U-251 MG, JEG-3, and HK2 cells

738
IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models

SW Lu, HC Pan, YH Hsu, KC Chang, LW Wu, WY Chen, MS Chang

Nature Communications (Nature) Taiwan, 14 September 2020

Oncology

Key words: Interleukins, Pancreatic Cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

739
In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP) 1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta

S Granitzer, I Ellinger, R Khan, K Gelles, R Widhalm, M Hengstschläger, H Zeisler, G Desoye, L Tupova, M Ceckova, H Salzer, C Gundacker

Archives of Toxicology (Springer) Austria, Czech Republic, 11 September 2020

Toxicology

Key words: Multidrug Resistance-Associated Protein 1, Methyl Mercury, HTR-8/Svneo, MDCKII, Oxidative Stress, Human Placenta

Organism: Human

Tissue: Placenta

740
The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix

S Taylor, M Whitfield, J Barratt, A Didangelos

The Journal of Immunology (American Association of Immnologists) UK, 11 September 2020

Immunology

Organism: Human

Tissue: Kidney

741
Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury

S Lu, Y Tian, Y Luo, X Xu, W Ge, G Sun, X Sun

Journal of Advanced Research (Elsevier) China, 09 September 2020

Cardiology

Key words: Myocardial Ischemia-Reperfusion, Macrophage, Iminostilbene, Pyruvate Kinase M2

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

742
Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis

Z Guan, Z Chen, S Fu, L Dai, Y Shen

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China, 03 September 2020

Neuroscience

Key words: Alzheimer’s Disease, Progranulin, Aβ, BACE1, Microglia

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

743
Integrin VLA-4 as a PET imaging biomarker of hyper-adhesion in transgenic sickle mice

LA Perkins, L Nyiranshuti, L Little-Ihrig, JD Latoche, KE Day, Q Zhu, S Tavakoli, P Sundd, EM Novelli, CJ Anderson

Blood Advances (ASH Publications) USA, 03 September 2020

Cardiology

Key words: Adhesions, Biological Markers, Diagnostic Imaging, Integrins, Mice, Monoclonal Antibodies, Positron-Emission Tomography, Selectins, Flow Cytometry, Femur

Organism: Mouse

Tissue: Bone, Spleen

744
Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft

M Enayati, S Puchhammer, J Iturri, C Grasl, C Kaun, S Baudis, I Walter, H Schima, R Liska, J Wojta, JL Toca-Herrera, BK Podesser, H Bergmeister

Journal of the Mechanical Behavior of Biomedical Materials (Elsevier) Austria, 03 September 2020

Tissue Engineering

Key words: Biodegradation, Mechanical Stability, Macrophages, Thermoplastic Polyurethane, Cell Culture, Rat Model

Organism: Rat

745
Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft

M Enayati, S Puchhammer, J Iturri, C Grasl, C Kaun, S Baudis, I Walter, H Schima, R Liska, J Wojta, JL Toca-Herrera, BK Podesser, H Bergmeister

Journal of the Mechanical Behavior of Biomedical Materials (Elsevier) Austria, 03 September 2020

Biological Materials

Key words: Biodegradation, Mechanical Stability, Macrophages, Thermoplastic Polyurethane, Cell Culture, Rat Model

746
Murine induced pluripotent stem cell‐derived neuroimmune cell culture models emphasize opposite immune‐effector functions of interleukin 13‐primed microglia and macrophages in terms of neuroimmune toxicity

A Quarta, T Meese, Z Pieters, E Van Breedam, D Le Blon, J Van Broeckhoven, S Hendrix, H Goossens, N Hens, Z Berneman, F Van Nieuwerburgh, P Ponsaerts

GLIA (Wiley) Belgium, Germany, Spain, The Netherlands, 31 August 2020

Neuroscience

Key words: Bioluminescence Imaging, Interleukin 13, iPSC, Macrophages, Microglia, Neurotoxicity, Transcriptome

Organism: Human

Cell Line: iPSC‐macrophages

747
The Secretome of Stressed Peripheral Blood Mononuclear Cells Increases Tissue Survival in a Rodent Epigastric Flap Model

S Hacker, R Mittermayr, D Traxler, C Keibl, A Resch, S Salminger, H Leiss, P Hacker, C Gabriel, B Golabi, R Pauzenberger, P Slezak, M Laggner, M Mildner, W Michlits, HJ Ankersmit

Bioengineering & Translational Medicine (Wiley) Austria, 30 August 2020

Tissue Engineering

Key words: Secretome, Angiogenesis, Flap Surgery, Necrosis Reconstructive Surgery, Tissue Regeneration

Organism: Rat

Tissue: Skin

748
Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential‐dependent NET‐formation

M Reithofer, J Karacs, J Strobl, C Kitzmüller, D Polak, K Seif, M Kamalov, CFW Becker, G Greiner, K Schmetterer

The FASEB Journal (Wiley) Austria, 29 August 2020

Cardiology

Key words: Aluminium Hydroxide, Vaccine, Adjuvant, Innate Response, Neutrophils, NET

Organism: Human

Tissue: Skin

749
Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation

Y Zhou, M Yan, R Pan, Z Wang, X Tao, C Li, T Xia, X Liu, Q Chang

Journal of Ethnopharmacology (Elsevier) China, 28 August 2020

Neuroscience

Key words: Depression, Radix Polygalae, Chronic Restraint Stress, Autophagy, Neuroinflammation

Organism: Mouse

Tissue: Brain

750
Topography-Mediated Myotube and Endothelial Alignment, Differentiation, and Extracellular Matrix Organization for Skeletal Muscle Engineering

AM Almonacid Suarez, MGL Brinker, LA Brouwer, I van der Ham, MC Harmsen, P van Rijn

Polymers (MDPI) The Netherlands, 28 August 2020

Tissue Engineering

Key words: Myoblasts, Topography, Vascularization, Endothelial Cells, Skeletal Muscle, Extracellular Matrix

Organism: Human

Tissue: Muscle

751
Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor

L Iamartino, T Elajnaf, K Gall, J David, T Manhardt, P Heffeter, M Grusch, S Derdak, S Baumgartner-Parzer, M Schepelmann, E Kallay

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (Elsevier) Austria, 27 August 2020

Oncology

Key words: Calcium-Sensing Receptor, Calcimimetic, Colorectal Cancer, Inflammation, Intestine

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

752
The Effects of Skin Lesion Segmentation on the Performance of Dermatoscopic Image Classification

A Mahbod, P Tschandl, G Langs, R Ecker, I Ellinger

Computer Methods and Programs in Biomedicine (Elsevier) Austria, 26 August 2020

Medical Image Analysis

Key words: Skin Cancer, Dermatoscopy, Medical Image Analysis, Deep Learning, Effect of Segmentation on Classification

753
Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

JK Sa, N Chang, HW Lee, HJ Cho, M Ceccarelli, L Cerulo, J Yin, SS Kim, FP Caruso, M Lee, D Kim, YT Oh, Y Lee, NG Her, B Min, HJ Kim, DE Jeong, HM Kim, H Kim, S Chung, HG Woo, J Lee, DS Kong, HJ Seol, JI Lee, J Kim, WY Park, Q Wang, Erik P Sulman, AB Heimberger, M Lim, JB Park, A Iavarone, RGW Verhaak, DH Nam

Genome Biology (BMC) South Korea, Italy, China, USA, 26 August 2020

Oncology

Organism: Human

Tissue: Brain

Pathological State: Cancer

754
Hindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption

R Gong, S Xu, A Hermundstad, Y Yu, SM Sternson

CELL (Cell Press) USA, 24 August 2020

Neuroscience

Key words: Hunger, Thirst, Palatability, Locus Coeruleus, Locus Ceruleus, periLC, Ingestive Behavior, Appetite, In Vivo Calcium Imaging, GRIN Lens

Organism: Mouse

755
Interruption of vascular endothelial growth factor receptor 2 signaling induces a proliferative pulmonary vasculopathy and pulmonary hypertension

MP Winter, S Sharma, J Altmann, V Seidl, A Panzenböck, A Alimohammadi, T Zelniker, B Redwan, F Nagel, D Santer, A Stieglbauer, B Podesser, M Sibilia, T Helbich, G Prager, A Ilhan-Mutlu, M Preusser, IM Lang

Basic Research in Cardiology (Springer) Austria, Germany, 23 August 2020

Pulmonology

Key words: Pulmonary Hypertension, VEGFR-2, FLK, Kdr, Murine Model

Organism: Mouse

Tissue: Lung

756
Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19

N Kaneko, HH Kuo, J Boucau, JR Farmer, H Allard-Chamard, VS Mahajan, A Piechocka-Trocha, K Lefteri, M Osborn, J Bals, YC Bartsch, N Bonheur, TM Caradonna, J Chevalier, F Chowdhury, TJ Diefenbach, K Einkauf, J Fallon, J Feldman, KK Finn, P Garcia-Broncano, C Adijaya Hartana, BM Hauser, C Jiang, P Kaplonek, M Karpell, EC Koscher, X Lian, H Liu, J Liu, NL Ly, AR Michell, Y Rassadkina, K Seiger, L Sessa, S Shin, N Singh, W Sun, X Sun, HJ Ticheli, MT Waring, AL Zhu, G Alter, JZ Li, D Lingwood, AG Schmidt, M Lichterfeld, BD Walker, XG Yu, RF Padera Jr, S Pillai

CELL (Cell Press) USA, Canada, 19 August 2020

SARS-CoV-2

Key words: SARS-CoV-2, COVID-19, T Follicular Helper Cells, Germinal Centers, Double-Negative B Cells, Extra-Follicular B Cells, Plasmablasts, Humoral Immunity, TNF-α, Cytokine Dysregulation

Organism: Human

Tissue: Lymphoid Tissue, Spleen

Pathological State: Covid-19

757
Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

R Vatapalli, V Sagar, Y Rodriguez, JC Zhao, K Unno, S Pamarthy, B Lysy, J Anker, H Han, YA Yoo, M Truica, ZR Chalmers, F Giles, J Yu, D Chakravarti, B Carneiro, SA Abdulkadir

Nature Communications (Nature) USA, 19 August 2020

Oncology

Key words: Epigenomics, Prostate Cancer, Targeted Therapies

Organism: Human

Tissue: Prostate

Pathological State: Cancer

758
Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer

V Stary, B Wolf, D Unterleuthner, J List, M Talic, J Längle, A Beer, J Strobl, G Stary, H Dolznig, M Bergman

Journal for ImmunoTherapy of Cancer (BMJ Journals) Austria, 18 August 2020

Oncology

Key words: Macrophages, Radiotherapy, Tumor Microenvironment

Organism: Human

Tissue: Colon

Pathological State: Cancer

759
Epithelial cell–specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice

HC Do-Umehara, C Chen, Q Zhang, AV Misharin, H Abdala-Valencia, SM Casalino-Matsuda, PA Reyfman, KR Anekalla, FJ Gonzalez-Gonzalez, MA Sala, C Peng, P Wu, CCL Wong, R Kalhan, A Bharat, H Perlman, KM Ridge, JI Sznajder, PHS Sporn, NS Chandel, J Yu, X Fu, I Petrache, R Tuder, GRS Budinger, J Liu

Science Advances (AAAS) USA, China, 14 August 2020

Immunology

Organism: Human

Tissue: Lung

Pathological State: Chronic Obstructive Pulmonary Disease

760
Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring-Role for AREG-induced EGFR signaling.

K Lkhagvadorj, Z Zeng, J Song, M Reinders-Luinge, W Kooistra, S Song

American Journal of Physiology (APS Journals) The Netherlands, China, 12 August 2020

Pulmonology

Key words: Prenatal Smoke Exposure, Epithelial Cell Differentiation, Amphiregulin, Lung Organoids

Organism: Mouse

Tissue: Lung

761
Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression

CC Lin, IY Kuo, LT Wu, WH Kuan, SY Liao, J Jen, YE Yang, CW Tang, YR Chen, YC Wang

Theranostics (Ivyspring International Publisher) Taiwan, 08 August 2020

Oncology

Key words: Lung Cancer, Kras, Shh, Transcription, Angiogenesis

Organism: Human

Tissue: Lung

Pathological State: Cancer

762
The effects of CYP24A1 on clinicopathological features and the prognosis of pancreatic ductal adenocarcinoma

W Gao, TF Wang, W Yi, WM Tong

Translational Cancer Research (AME Publishing Company) China, 08 August 2020

Oncology

Key words: CYP24A1, Pancreatic Cancer, Prognosis

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

763
Human FBXL8 Is a Novel E3 Ligase Which Promotes BRCA Metastasis by Stimulating Pro-Tumorigenic Cytokines and Inhibiting Tumor Suppressors

SC Chang, W Hsu, ECY Su, CS Hung, JL Ding

Cancers (MDPI) Taiwan, Singapore, 07 August 2020

Oncology

Key words: FBXL8 SCF E3 Ubiquitin Ligase, CCND2, IRF5, Breast Cancer (BRCA) And Metastasis, Pro-Tumorigenic Microenvironment

Organism: Human

Cell Line: MCF7 and MDA-MB231 cells

764
Pyramidal shaped ceria nano-biointerfaces for studying the early bone cell response

AF Bonciu, S Orobeti, LE Sima, M Icriverzi, M Filipescu, A Moldovan, A Popescu, V Dinca, M Dinescu

Applied Surface Science (Elsevier) Romania, 06 August 2020

Biological Materials

Key words: Pyramidal Shaped Ceria Nano-Biointerfaces, PLD, Cells Response

Organism: Human

Cell Line: Human osteosarcoma cells (SaOs-2)

765
Sodium Cholate Bile Acid-Stabilized Ferumoxytol-Doxorubicin-Lipiodol Emulsion for Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

K Kwak, B Yu, SK Mouli, AC Larson, DH Kim

Journal of Vascular and Interventional Radiology (Elsevier) USA, 06 August 2020

Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

766
Light‐emitting diode irradiation induces AKT/mTOR‐mediated apoptosis in human pancreatic cancer cells and xenograft mouse model

YM Kim, SH Ko, YI Shin, Y Kim, T Kim, J Jung, SY Lee, NG Kim, KJ Park, JH Ryu

Journal of Cellular Physiology (Wiley Online Library) South Korea, 04 August 2020

Oncology

Key words: AKT/mTOR Pathway, Apoptosis, LED Irradiation, Pancreatic Cancer, Tumor Growth

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

767
Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

M Srivastava, Y Zhang, J Chen, D Sirohi, A Miller, Y Zhang, Z Chen, H Lu, J Xu, RJ Kuhn, WA Tao

Nature Communications (Nature) USA, China, 04 August 2020

Virology

Key words: Chemical Tools, Proteomics, Virus–Host Interactions

Organism: Human

Cell Line: HEK293T cells

768
Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes

YJ Huang, TH Huang, VK Yadav, M Rachmawati Sumitra, DTW Tzeng, PL Wie, JW Shih, ATH Wu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, China, 01 August 2020

Oncology

Key words: Colon Cancer Stem Cells, Tumor Microenvironment, 5-FU Resistance, Tumorsphere Derived Exosomes, Β-Catenin/STAT3/MiR-1246 Signaling, Ovatodiolide

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

769
Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells

A Yawer, E Sychrová, P Labohá, J Raška, T Jambor, P Babica, I Sovadinová

Toxicology and Applied Pharmacology (Elsevier) Czech Republic, Slovakia, 31 July 2020

Endocrinology

Key words: Connexins, Endocrine-Disrupting Chemicals, Gap Junctional Intercellular Communication, Leydig Cells, Reproductive Toxicants, Steroidogenesis

Organism: Mouse

Cell Line: Leydig TM3 cells

770
A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model

IJ Su, HY Chang, HC Wang, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan, 30 July 2020

Neuroscience

Key words: Alzheimer’s Disease Therapy, Curcumin Analog, TML-6, Aging, Bioavailability

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

771
Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin

L Molcan, A Maier, A Zemančíková, K Gelles, J Török, M Zeman, I Ellinger

Cellular and Molecular Neurobiology (Springer) Slovakia, Austria, 30 July 2020

Cardiology

Key words: Rat Melatonin Receptor MT1, Melatonin, Mesenteric Artery (MA), Perivascular Fat Tissue (PVAT), Neurogenic Contraction

Organism: Rat

Tissue: Eye, Brain

772
Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy

J Ye, S Lu, M Wang, W Ge, H Liu, Y Qi, J Fu, Q Zhang, B Zhang, G Sun, X Sun

Frontiers in Pharmacology (Frontiers Media S.A.) China, 30 July 2020

Cardiology

Key words: Myocardial Ischemia Reperfusion Injury, Hydroxysafflor Yellow A, NLRP3, Autophagy, AMPK

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

773
NHF-derived carbon dots: prevalidation approach in breast cancer treatment

CE Tiron, G Luta, M Butura, F Zugun-Eloae, CS Stan, A Coroaba, EL Ursu, G Dumitrita Stanciu, A Tiron

Scientific Reports (Nature) Romania, 29 July 2020

Oncology

Key words: Cancer, Drug Development, Medical Research, Oncology, Preclinical Research, Translational Research

Organism: Human

Cell Line: HUVECs and PASMCs

774
BMI1-Mediated Pemetrexed Resistance in Non-Small Cell Lung Cancer Cells Is Associated with Increased SP1 Activation and Cancer Stemness

HT Shen, PJ Chien, SH Chen, GT Sheu, MS Jan, BY Wang, WW Chang

Cancers (MDPI) Taiwan, 27 July 2020

Oncology

Key words: BMI1, SP1, Pemetrexed Resistance, Non Small Cell Lung Cancer, Cancer Stem Cells, Epithelial–Mesenchymal Transition

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

775
A general method to optimize and functionalize red-shifted rhodamine dyes

JB Grimm, AN Tkachuk, L Xie, H Choi, B Mohar, N Falco, K Schaefer, R Patel, Q Zheng, Z Liu, J Lippincott-Schwartz, TA Brown, LD Lavis

Nature Methods (Nature) USA, 27 July 2020

Biological Methods

Key words: Chemical Biology, Chemical Tools, Fluorescence Imaging, Imaging

Organism: Mouse

Tissue: Brain

776
Ready to go 3D? A semi-automated protocol for microwell spheroid arrays to increase scalability and throughput of 3D cell culture testing

A Basu, A Dydowiczová, JE Trosko, L Bláha, P Babica

Toxicology Mechanisms and Methods (Taylor & Francis) Czech Republic, USA, 26 July 2020

Biological Methods

Organism: Human

Cell Line: HL1-hT1 cells and HepG2 cells

777
Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents–Implications for oxidative UV damage

C Kremslehner, A Miller, R Nica, IM Nagelreiter, MS Narzt, B Golabi, V Vorstandlechner, M Mildner, J Lachner, E Tschachler, F Ferrara, K Klavins, M Schlosserer, J Grillari, A Haschemi, F Gruber

Redox Biology (Elsevier) Austria, Italy, USA, 19 July 2020

Dermatology

Organism: Human

Tissue: Skin

778
Enterocyte-Based Bioassay via Quantitative Combination of Proinflammatory Sentinels Specific to 8-keto-trichothecenes

SH Park, Y Moon

Frontiers in Immunology (Frontiers Media S.A.) South Korea, 16 July 2020

Immunology

Key words: 8-Keto-Trichothecene, Ribotoxic Stress, Inflammation, Epithelium, Reporter Biomonitoring

Organism: Mouse

Tissue: Small Intestine

779
Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets

P Haider, JB Kral-Pointner, J Mayer, M Richter, C Kaun, C Brostjan, W Ellenberg, MB Fischer, WS Spledl, C Hengstenberg, K Huber, J Wojta, P Hohensinner

Arteriosclerosis, Thrombosis and Vascular Biology (American Heart Association) Austria, 16 July 2020

Cardiology

Key words: Aortic Aneurysm, Extracellular Traps, Humans, Macrophages, Thrombosis

Organism: Mouse

Cell Line: Blood

780
Pre-and post-irradiation mild hyperthermia enabled by NIR-II for sensitizing radiotherapy

Q Li, L Hang, W Jiang, J Dou, L Xiao, X Tang, Y Yao, Y Wang

Biomaterials (Elsevier) China, 14 July 2020

Biological Materials

Key words: Au Nanobipyramids, Second Near-Infrared Window, Mild Hyperthermia, Radiotherapy

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

781
Antidiabetic activity in vitro and in vivo of BDB, protein tyrosine phosphatase 1B selective inhibitor from Rhodonela conferviodes

J Luo, M Zheng, B Jiang, C Li, S Guo, L Wang, X Li, R Yu, D Shi

British Journal of Pharmacology (Wiley) China, 14 July 2020

Pharmacology

Key words: Bromophenol, PTP1B Inhibitor, Selectivity, Cell Permeability, Oral Bioavailability

Organism: Mouse

Tissue: Pancreas

Pathological State: Diabetes

782
Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

D Dems, R Freeman, T Coradin, SI Stupp, C Aime

Acta Biomaterialia (SSRN) France, USA, 13 July 2020

Biological Materials

Key words: Peptide Amphiphile, Silica Particles, Nanobiocomposites, Hybrid Biomaterials, Clustering

Organism: Mouse

Cell Line: NIH 3T3 fibroblasts

783
Lycopene Inhibit IMQ-Induced Psoriasis-Like Inflammation by Inhibiting ICAM-1 Production in Mice

CM Shih, CK Hsieh, CY Huang, CY Huang, KH Wang, TH Fong, NTT Trang, KT Liu, AW Lee

Polymers (MDPI) Taiwan, 09 July 2020

Dermatology

Key words: Lycopene, Psoriasis

Organism: Mouse

Tissue: Skin

Pathological State: Psoriasis

784
Using Cytometry for Investigation of Purinergic Signaling in Tumor‐Associated Macrophages

VF Arnaud‐Sampaio, ILA Rabelo, CA Bento, T Glaser, J Bezerra, R Coutinho-Silva, H Ulrich, C Lameu

Cytometry Part A (Wiley) Brazil, 07 July 2020

Oncology

Key words: Macrophage, TAM, Cancer Stem Cells, Purines, ATP, Purinergic System, EMT, Image Cytometry

Organism: Human

Pathological State: Cancer

Cell Line: Macrophages

785
Multimodal single‐cell analysis reveals distinct radioresistant stem‐like and progenitor cell populations in murine glioma

J Alexander, QC LaPlant, SS Pattwell, F Szulzewsky, PJ Cimino, FP Caruso, P Pugliese, Z Chen, F Chardon, AJ Hill, C Spurrell, D Ahrendsen, A Pietras, LM Starita, D Hambardzumyan, A Iavarone, J Shendure, EC Holland

GLIA (Wiley) USA, Italy, Sweden, 04 July 2020

Neuroscience

Key words: Glioma, Glioma Stem Cells, Myeloid Cells, Radiation Response, Radioresistance, Single‐Cell RNA Sequencing, SP Analysis

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

786
Catching Common Cold Virus with a Net: Pyridostatin Forms Filaments in Tris Buffer That Trap Viruses—A Novel Antiviral Strategy?

A Real-Hohn, R Zhu, H Ganjian, N Ibrahim, P Hinterdorfer, H Kowalski, D Blaas

Viruses (MDPI) Austria, Sweden, 04 July 2020

Virology

Key words: Enterovirus, Rhinovirus, Pyridostatin, Filament, Extracellular Traps

Organism: Human

Cell Line: HeLa Cells

787
Fewer tumour-specific PD-1+ CD8+ TILs in high-risk “Infiltrating” HPV− HNSCC

K Xu, Y Fu, Y Han, R Xia, S Xu, S Duan, Z Zhang, J Li

British Journal of Cancer (Nature) China, 03 July 2020

Oncology

Key words: Head and Neck Cancer, Tumour Immunology

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

788
Slug Is A Surrogate Marker of Epithelial to Mesenchymal Transition (EMT) in Head and Neck Cancer

TB Steinbichler, J Dudas, J Ingruber, R Glueckert, S Sprung, F Fleischer, N Cidlinsky, D Dejaco, B Kofler, AI Giotakis, II Skvortsova, H Riechelmann

Journal of Clinical Medicine (MDPI) Austria, 30 June 2020

Oncology

Key words: Image Cytometry, p16, p53, Cancer Stem Cells, E-Cadherin, β -Catenin, EMT, Head and Neck Cancer

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

789
Functional characterization of the basal amygdala-dorsal BNST pathway during contextual fear conditioning

JS Russell, S Trouche, LG Reijmers

eNeuro (Society for Neuroscience) USA, 29 June 2020

Neuroscience

Key words: Contextual Fear, Fear Memorybasal Amygdala, Bed Nucleus of The Stria Terminalis, Neural Circuits, Encoding, Fear Engram

Organism: Mouse

Tissue: Brain

790
Tissues derived from reprogrammed Wharton's jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus

CM Kong, A Subramanian, SU Gan, A Biswas, B Ariff, CY Fong

Stem Cell Research (Elsevier) Singapore, 26 June 2020

Stem Cell Research

Key words: Gestational Diabetes Mellitus, Induced Pluripotent Stem Cells, Reprogramming, Wharton’s Jelly Stem Cells, Pancreatic Cells

Organism: Human

Pathological State: Gestational Diabetes

Cell Line: iPSCs

791
Comparison between paramagnetic and CD71 magnetic activated cell sorting of fetal nucleated red blood cells from the maternal blood

D Nemescu, D Constantinescu, V Gorduza, A Carauleanu, L Caba, DB Navolan

Journal of Clinical Laboratory Analysis (Wiley) Romania, 25 June 2020

Biological Methods

Key words: CD71, Fluorescent in Situ Hybridization, Magnetic‐Activated Cell Sorting, Nucleated Red Blood Cells, Prenatal Diagnosis

Organism: Human

Cell Line: Blood

792
BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer

YC Hsu, CW Luo, WL Huang, CC Wu, CL Chou, CI Chen, SJ Chang, CY Chai, HC Wang, TY Chen, CF Li, MR Pan

Radiotherapy and Oncology (Elsevier) Taiwan, 24 June 2020

Radiotherapy, Oncology

Key words: BMI1, CCRT, Rectal Cancers, Radioresistance

Organism: Human

Tissue: Colon

Pathological State: Cancer

793
The chemokine lymphotactin and its recombinant variants in oral cancer cell regulation

AZ Abdullah Zubir, SA Whawell, TS Wong, SA Khurram

Oral Diseases (Wiley) UK, 19 June 2020

Oncology

Key words: Cancer‐Associated Fibroblast, Lymphotactin, Oral Squamous Cell Carcinoma, Tumour Microenvironment, XCR1

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

794
p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection

H Ishida, A Kasajima, F Fujishima, R Akaishi, S Ueki, Y Yamazaki, Y Onodera, X Gao, H Okamoto, Y Taniyama, T Kanei, H Sasano

Virchows Archiv (Springer) Japan, Australia, Germany, 16 June 2020

Oncology

Key words: Esophagus, Small-Cell Carcinoma, Poorly Differentiated Squamous Cell Carcinoma, Basaloid Squamous Cell Carcinoma, P16, Human Papillomavirus

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

795
Reciprocal Regulation Between Indoleamine 2, 3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells

HY Low, YC Lee, YJ Lee, HL Wang, YI Chen, PJ Chien, ST Li, WW Chang

Cancers (MDPI) Taiwan, 12 June 2020

Oncology, Stem Cell Research

Key words: IDO1, Notch1, Radiation, Cervical Cancer, Cancer Stem Cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

796
Tumor Microenvironment Targeting Nano–Bio Emulsion for Synergistic Combinational X‐Ray PDT with Oncolytic Bacteria Therapy

W Park, S Cho, D Kang, JH Han, JH Park, B Lee, J Lee, DH Kim

Advanced Healthcare Materials (Wiley) South Korea, USA, 11 June 2020

Oncology, Nanomedicine

Key words: Bacteriolytic Therapy, Nano–Bio Emulsions, Scintillating Nanoparticles, Tumor Microenvironments, X‐Ray Photodynamic Therapy (PDT)

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

797
Regulatory T cells promote adipocyte beiging in subcutaneous adipose tissue

W Fang, Z Deng, F Benadjaoud, D Yang C Yang, GP Shi

The FASEB Journal (Wiley) USA, China, 08 June 2020

Immunology

Key words: Epididymal White Adipose Tissue, Gonadal White Adipose Tissue, Macrophage Polarization, Regulatory T Cell, Subcutaneous Adipose Tissue, Uncoupling Protein‐1

798
Yttrium-90 Radioembolization and Tumor Hypoxia: Gas-challenge BOLD Imaging in the VX2 Rabbit Model of Hepatocellular Carcinoma

AC Gordon, SB White, VL Gates, D Procissi, KR Harris, Y Yang, Z Zhang, W Li, T Lyu, X Huang, RA Omary, R Salem, RJ Lewandowski, AC Larson

Academic Radiology (Elsevier) USA, 07 June 2020

Radiotherapy, Oncology

Key words: Oxygenation, Hepatic Radioembolization, Magnetic Resonance Imaging, Yttrium-90

Organism: Rabbit

Tissue: Kidney

Pathological State: Cancer

799
A prominent environmental endocrine disruptor, 4-nonylphenol, promotes endometriosis development via plasmacytoid dendritic cells

P Sharma, HH Tzeng, JYL Lee, EM Tsai, JL Suen

Molecular Human Reproduction (Oxford Academic) Taiwan, 04 June 2020

Reproductive Medicine

Key words: CD36, Endometriosis, Environmental Endocrine Disruptor, Estrous Cycle, IL-10, 4-Nonylphenol, Plasmacytoid Dendritic Cell

Organism: Mouse

Tissue: Uterus

Pathological State: Endometriosis

800
A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure

H Shawer, E Aiyelaagbe, C Clowes, SC Lean, Y Lu, KE Kadler, A Kerby, MR Dilworth, KE Hentges, AEP Heazell

PLoS One (PLOS) UK, 03 June 2020

Reproductive Medicine

Key words: Mouse Models, Stillbirths, Embryos, Placenta, Fetal Death, Myocardium, Heart, Giant Cells

Organism: Mouse

Tissue: Placenta

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