Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3222 papers published)

Results 601 - 610 of 3222
601
Exploring CD39 and CD73 Expression as Potential Biomarkers in Prostate Cancer

CFF Gardani, EL Pedrazza, VS Paz, GG Zanirati, J Costa da Costa, R Andrejew, H Ulrich, JN Scholl, F Figueiró, L Rockenbach, F Bueno Morrone

Pharmaceuticals (MDPI) Brazil , 16 November 2023

Oncology

Key words: prostate cancer; ectonucleotidases; CD39; CD73; extracellular vesicles

Organism: Human

Tissue: Prostate

Pathological State: Cancer

602
Structural, electrochemical, biological, and mechanical assessment of functionally graded Cr-based multilayers for enhanced metal-ceramic bond strength in dental restorations

M Dinu, CM Cotrut, T Petreus, T Hauffman, F Baciu, A Vladescu

Materials Chemistry and Physics (Elsevier) Romania, UK, Belgium, Russia , 15 November 2023

Biomaterials

Key words: Oxynitride, Cathodic arc, EIS, Cytotoxicity, Bond strength

Cell Line: Human gingival fibroblasts

603
Impact of the-1T> C single-nucleotide polymorphism of the CD40 gene on the development of endothelial dysfunction in a pro-diabetic microenvironment

P Joshi, F Mohr, C Rumig, E Kliemank, G Krenning, S Kopf, M Hecker, AH Wagner

Atherosclerosis (Elsevier) Germany, The Netherlands , 14 November 2023

Endocrinology

Key words: Single nucleotide polymorphism, CD40, Endothelial cells, Endothelial-to-mesenchymal transition

Pathological State: Type 2 diabetes and type 1 diabetes

Cell Line: Human endothelial cells

604
Transcriptional regulation of macrophage inflammation in the heart failure with preserved ejection fraction: a translational study

E Gorica, SA Mohammed, A Mengozzi, S Ambrosini, FA Wenzl, A Mongelli, F Ruschitzka, N Hamdani, S Costantino, F Paneni

European Heart Journal (Oxford Academic) , 09 November 2023

605
Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling

Q Wang, H Lin, C Shen, M Zhang, X Wang, M Yuan, M Yuan, S Jia, Z Cao, C Wu, B Chen, A Gao, Y Bi, G Ning, W Wang, J Wang, R Liu

Gut Microbes (Taylor & Francis) China , 09 November 2023

Gastroenterology

Key words: Microbiome, GLP-1, bile acid, TGR5, ileum, diabetes

Organism: Mouse

Tissue: Small Intestine

Pathological State: Induced Intestinal Fibrosis

606
Autopsy analysis reveals increased macrophage infiltration and cell apoptosis in COVID-19 patients with severe pulmonary fibrosis

SQ Xiao, TZ Wen, XY Chen, HY Chen, Z Li, ZC He, T Luo, R Tang, WJ Fu, MF Cao, L Chen, Q Niu, S Wang, Y Lan, J Ge, QR Li, HT Guo, YX Wang, YF Ping, H Shen, Y Wang, YQ Ding, XW Bian, XH Yao

Pathology - Research and Practice (Elsevier) China , 08 November 2023

Virology

Key words: COVID-19, Respiratory failure, Histopathology, Macrophage, Apotosis

Organism: Human

Tissue: Lung

Pathological State: Viral Infection

607
Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K

Y Miyahara, H Chen, M Moriyama, K Mochizuki, N Kaneko, AR Haque, A Chinju, K Kai, M Sakamoto, N Kakizoe-Ishiguro, M Yamauchi, K Ogata, T Kiyoshima, S Kawano, S Nakamura

Scientific reports (Nature) Japan, Bangladesh , 07 November 2023

Immunology, Dermatology

Key words: Inflammation, Innate immunity, Lymphocytes, Mucosal immunology

Organism: Human

Tissue: Mucosa

Pathological State: Oral Lichen Planus (OLP) and hyperkeratosis

608
A novel lncRNA GM15416 regulates osteoblast apoptosis and differentiation through the c-Fos/Fas axis and mitigates osteoporosis

D Zhao, J He, X Zhao, X Sheng, Z Feng, X Wang, C Zhang, S Wang, B Geng, Y Xia

International Journal of Biological Macromolecules (Elsevier) China , 02 November 2023

Osteology

Key words: lncRNA GM15416, C-Fos, Osteoporosis

Organism: Mouse

Tissue: Bone

Pathological State: osteoporosis

609
Heterogeneity of Phase II Enzyme Ligands on Controlling the Progression of Human Gastric Cancer Organoids as Stem Cell Therapy Model

DC Wu, CC Ku, JB Pan, K Wuputra, YH Yang, CJ Liu, YC Liu, K Kato, S Saito, YC Lin, IW CHong, M Hsiao, HM Hu, CH Kuo, KK Kuo, CS Lin, KK Yokoyama

International Journal of Molecular Sciences (MDPI) Taiwan , 02 November 2023

Oncology, Stem Cell Research

Key words: cinnamaldehyde; gastric cancer development; organoids; perillaldehyde; reactive oxygen species

Organism: Human

Tissue: Organoid

Pathological State: Cancer

610
Topical application of synthetic melanin promotes tissue repair

D Biyashev, ZE Siwicka, UV Onay, M Demczuk, D Xu, MK Ernst, ST Evans, CV Nguyen, FA Son, NK Paul, NC McCallum, OK Farha, SD Miller, NC Gianneschi, KQ Lu

NPJ Regenerative Medicine (Nature) USA , 02 November 2023

Dermatology

Key words: Biomaterials, Cell death and immune response, Trauma

Organism: Mouse

Tissue: Skin

Pathological State: Acute skin injury

Results 601 - 610 of 3222
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