Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Filter publications

Customer Publications (A total of 2889 papers published)

601
miR-432 exerts a protective effect against myocardial ischemia/reperfusion injury by activating the β-catenin/HIF-1α pathway and augmenting NRF2-mediated anti-oxidative stress

RY Su, WY Tai, HS Yin, XY Geng

American Journal of Translational Research (e-Century Publishing Corporation) China, 15 January 2023

Cardiology

Key words: apoptosis, microRNA, myocardial ischemia/reperfusion injury, oxidative stress

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Ischemia

602
Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia–reperfusion injury

T Mei, J Wu, K Wu, M Zhao, J Luo, X Liu, B Shang, W Xu, Z Yang, Y Lai, C Liu, H Gong, X Gao, Y Zhuo, M Lin, L Zhao

Annals of Translational Medicine (AME Publishing Company) China, 15 January 2023

Ophthalmology

Key words: Lipocalin-2 (LCN2), retinal ischemia-reperfusion injury (RIR injury), ferroptosis, retinal ganglion cell (RGC), visual impairment

Organism: Mouse

Tissue: Eye

Pathological State: Retinal Ischemia

603
SN‐38, an active metabolite of irinotecan, enhances anti‐PD1 treatment efficacy in head and neck squamous cell carcinoma

YM Lee, YH Chen, DL Ou, CL Hsu, JH Liu, JY Ko, MCT Hu, CT Tan

The Journal of Pathology (Wiley) Taiwan, USA, 15 January 2023

Oncology

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

604
Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice

Q Ma, D Su, J Huo, G Yin, D Dong, K Duan, H Cheng, H Xu, J Ma, D Liu, B Mou, J Peng, L Cheng

Neuroscience Bulletin (Springer) China, 13 January 2023

Neuroscience

Key words: Microglia, Mechanical allodynia, Laterality, Spinal dorsal horn, Aβ, Dynamic allodynia, Punctate allodynia

Organism: Mouse

Tissue: Brain, Spinal Cord

Pathological State: Mechanical Allodynia

605
Production and characterization of cell-penetrating recombinant botulinum neurotoxin type A

X Wei, J Hu, L Jiang, L Li, J Liu

STAR Protocols (Elsevier) China, 13 January 2023

Biological Methods

Key words: Cell culture, Protein Biochemistry, Protein Expression and Purification, Biotechnology and Bioengineering

Cell Line: N2a cells

606
The imbalance of NKG2A and NKG2D expression is involved in NK cell immunosuppression and tumor progression of HBV‐HCC patients

L Yu, L Sun, X Liu, X Wang, H Yan, Q Pu, Y Xie, Y Jiang, J Du, Z Yang

Hepatology Research (Wiley) China, 11 January 2023

Oncology

Key words: NK cell, NKG2A, NKG2D, hepatitis B virus-related hepatocellular carcinoma, immunosuppression

Organism: Human

Tissue: Liver

Pathological State: Cancer

607
Theabrownin inhibits obesity and non-alcoholic fatty liver disease in mice via serotonin-related signaling pathways and gut-liver axis

HY Li, SY Huang, DD Zhou, RG Xiong, M Luo, A Saimaiti, MK Han, RY Gan, HL Zhu, HB Li

Journal of Advanced Research (Elsevier) China, 11 January 2023

Hepathology

Key words: non-alcoholic fatty liver disease, anti-obesity, theabrownin, serotonin, gut microbiota

Organism: Mouse

Tissue: Liver

608
Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

D Liu, C Liang, B Huang, X Zhuang, W Cui, L Yang, Y Yang, Y Zhang, X Fu, X Zhang, L Du, W Gu, X Wang, C Yin, R Chai, B Chu

Advanced Science (Wiley) China, USA, 10 January 2023

Oncology

Key words: 3-HA, 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), 5-HT, ferroptosis, kynureninase (KYNU, monoamine oxidase A (MAOA), tryptophan

Organism: Human

Tissue: Liver, Kidney

Pathological State: Cancer

609
Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy

R Chi, C Chai, G Liu, H Cao, B Yang

Human Cell (Springer) China, 10 January 2023

Cardiology

Key words: OSAS, CIH, Autophagy, BNIP3, Apoptosis, Cardiac hypertrophy

Organism: Rat

Tissue: Heart

Pathological State: Contractile dysfunction

610
Immune dysregulation in immunoglobulin G4–related disease

T Maehara, R Koga, S Nakamura

Japanese Dental Science Review (Elsevier) Japan, 09 January 2023

Immunology

Key words: Autoimmune, Anti-inflammatory, Single-cell RNA sequencing, IgG4-related disease, Cytotoxic T cells, Salivary gland

611
Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive 18F-FDG PET/CT and Serum 1H-NMR Analysis: An Orthotopic Murine Model Study

YH Chung, TH Hung, CF Yu, CK Tsai, CC Weng, F Jhang, FH Chen, G Lin

Metabolites (MDPI) Taiwan, 09 January 2023

Oncology

Key words: lung cancer, 18F-FDG, 1H-NMR, animal study, metastasis

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

612
Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance

F Du, G Yin, L Han, X Liu, D Dong, K Duan, J Huo, Y Sun, L Cheng

Neuroscience Bulletin (Springer) China, 09 January 2023

Neuroscience

Key words: μ-opioid receptor, Morphine, Mechanical allodynia, Punctate allodynia, Dynamic allodynia, OIH, Tolerance, Aβ-fiber

Organism: Mouse

Tissue: Brain, Spinal Cord

Pathological State: Mechanical Allodynia

613
Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts

YC Huang, MF Hou, YM Tsai, YC Pan, PH Tsai, YS Lin, CY Chang, EM Tsai, YL Hsu

Cellular Oncology (Springer) Taiwan, 06 January 2023

Oncology

Key words: Acetyl-CoA carboxylase α, Breast cancer, Metabolism reprogramming, Pre-metastatic niche, Senescence

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

614
Role of iodine density value on dual-energy CT for detection of high tumor cell proportion region in lung cancer during CT-guided transthoracic biopsy

Y Ma, S Li, G Huang, X Huang, Q Zhou, W Wang, J Wang, F Zhao, Z Li, X Chen, B Zhu, J Zhou

European Journal of Radiology (Elsevier) China, 06 January 2023

Oncology, Radiotherapy

Key words: Dual-layer spectral detector computed tomography, Iodine density, Transthoracic lung biopsy, High tumor cell proportion region

Organism: Human

Tissue: Lung

Pathological State: Cancer

615
Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis

BY Ahn, Y Jeong, S Kim, Y Zhang, SW Kim, YE Leem, JS Kang

Experimental & Molecular Medicine (Nature) South Korea, 06 January 2023

Cell Biology

Key words: Calcification, Stress signalling

Organism: Mouse

Tissue: Blood Vessels

616
PLVAP as an Early Marker of Glomerular Endothelial Damage in Mice with Diabetic Kidney Disease

EE Wolf, A Steglich, F Kessel, H Kröger, J Sradnick, S Reichelt-Wurm, K Eidenschink, MC Banas, E Wolf, R Wanke, F Gembardt, VT Todorov

International Journal of Molecular Sciences (MDPI) Germany, 06 January 2023

Nephrology

Key words: diabetic kidney disease, endothelial damage, PLVAP, diabetic models, glomerular hypertrophy

Organism: Mouse

Tissue: Kidney

Pathological State: Diabetic Kidney Disease

617
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity

Z Fu, S Chen, Y Zhu, D Zhang, P Xie, Q Jiao, J Chi, S Xu, Y Xue, X Lu, X Song, M Christofanilli, WJ Gradishar, K Kalinsky, Y Yin, B Zhang, Y Wan

Science Advances (Science) USA, China, 06 January 2023

Oncology

Organism: Human

Tissue: Breast

Pathological State: Cancer

618
The transcription factor Eomes promotes expression of inhibitory receptors on hepatic CD8+ T cells during HBV persistence

L Yu, Y Guan, L Li, N Lu, C Zhang

The FEBS Journal (Wiley) China, 05 January 2023

Virology, Immunology

Key words: CD8+ T cell exhaustion, chronic HBV persistence, Eomes, inhibitory receptor, transcription factor

Organism: Mouse

Tissue: Liver

Pathological State: Hepatitis B virus Infection

619
Comparing the Therapeutic Mechanism and Immune Response of Human and Mouse Mesenchymal Stem Cells in Immunocompetent Mice With Acute Liver Failure

CH Wang, CY Chen, KH Wang, AP Kao, YJ Chen, PH Lin, M Chen, TY Wu, JJ Cheng, KD Lee, KH Chuang

Stem Cells Translational Medicine (Oxford Academic) Taiwan, 04 January 2023

Immunology, Hepathology

Key words: mesenchymal stem cells, immunomodulatory, IL-6, F4/80, liver regeneration, liver fibrosis

Organism: Mouse

Tissue: Liver

Pathological State: Acute Liver Failure

620
Limonin counteracts obesity by activating thermogenesis in brown and white adipose tissues

M Yan, S Jin, Z Wang, T Xia, Y Liu, Q Chang

Journal of Functional Foods (Elsevier) China, 02 January 2023

Endocrinology

Key words: Limonin, Obesity, Brown adipose tissue, White adipose tissues, Thermogenesis

Organism: Mouse

Tissue: Liver

621
Nesfatin-1 stimulates CCL2-dependent monocyte migration and M1 macrophage polarization: implications for rheumatoid arthritis therapy

JW Chang, SC Liu, YY Lin, XY He, YS Wu, CM Su, CH Tsai, HT Chen, YC Fong, SL Hu, CC Huang, CH Tang

International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan, 01 January 2023

Rheumatology

Key words: rheumatoid arthritis, nesfatin-1, CCL2, M1 macrophages, synovial fibroblasts

Organism: Human, Mouse

Tissue: Joint Tissue

Pathological State: Rheumatoid Arthritis

622
Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma

JL Sieow, HL Penny, SY Gun, LQ Tan, K Duan, JPS Yeong, A Pang, D Lim, HC Toh, TKH Lim, E Engleman, O Rotzschke, LG Ng, J Chen, SM Tan, SC Wong

International Journal of Molecular Sciences (MDPI) Singapore, USA, 01 January 2023

Oncology

Key words: neutrophils, pancreatic cancer, hypoxia-inducible factor 1-alpha

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

623
The TgF344-AD Rat: Behavioral and Proteomic Changes Associated with Aging and Protein Expression in a Transgenic Rat Model of Alzheimer's Disease

B Bac, C Hicheri, C Weiss, A Buell, N Vilcek, C Spaeni, C Geula, JN Savas, JF Disterhoft

Neurobiology of Aging (Elsevier) USA, 30 December 2022

Neuroscience

Key words: watermaze, 6E10, pTau, neuroinflammation, TREM2, Learning Index, proteomics

Organism: Rat

Tissue: Brain

Pathological State: Alzheimer's Disease

624
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Y Zhou, X He, Y Jiang, Z Wang, Y Yu, W Wu, C Zhang, J Li, Y Huo, X Chen, Z Liu, J Zhao, K Liu, Z Dong

Frontiers of Medicine (Springer) China, 29 December 2022

Oncology

Key words: benzydamine, cyclin-dependent kinase 2, patient-derived xenograft, esophageal squamous cell carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

625
The effect of isovitexin on lipopolysaccharide-induced renal injury and inflammation by induction of protective autophagy

CY Tseng, PR Yu, CC Hsu, HH Lin, JH Chen

Food and Chemical Toxicology (Elsevier) Taiwan, 23 December 2022

Nephrology

Key words: Kidney injury, Isovitexin, Lipopolysaccharide, Inflammation, Autophagy

Organism: Mouse

Tissue: Kidney

Pathological State: Lipopolysaccharide-induced kidney injury

626
Myofibroblast stroma differentiation in infiltrative basal cell carcinoma is accompanied by regulatory T‐cells

JM Ressler, N Zila, A Korosec, J Yu, R Silmbrod, V Bachmayr, J Tittes, J Strobl, BM Lichtenberger, C Hoeller, P Petzelbauer

Journal of Cutaneous Pathology (Wiley) Austria, 23 December 2022

Oncology

Key words: Basal cell carcinoma, infiltrative BCC, regulatory T-cells, TGF-β, alpha smooth muscle actin

Organism: Human

Tissue: Skin

Pathological State: Cancer

627
Mitigation of Cellular and Bacterial Adhesion on Laser Modified Poly (2-Methacryloyloxyethyl Phosphorylcholine)/Polydimethylsiloxane Surface

S Nistorescu, M Icriverzi, P Florian, A Bonciu, V Marascu, N Dumitrescu, G Gradisteanu Pircalabioru, L Rusen, A Mocanu, A Roseanu, A Cimpean, F Grama 6, V Dinca, DA Cristian

Nanomaterials (MDPI) Romania, 23 December 2022

Tissue Engineering

Key words: MAPLE, zwitterionic coating, cellular response

Cell Line: Fibroblasts cultured on PDMS scaffolds

628
Biomimetic Prussian blue nanozymes with enhanced bone marrow-targeting for treatment of radiation-induced hematopoietic injury

B Zhang, G Chen, X Wu, Y Li, Y Xiao, J Li, L He, Y Li, S Wang, J Zhao, C Liu, H Zhou, Y Li, X Pei

Biomaterials (Elsevier) China, 21 December 2022

Nanomedicine

Key words: Prussian blue nanozymes, Mesenchymal stem cell membrane, Reactive oxygen species, Radiation-induced hematopoietic injury, Targeting therapy

Organism: Mouse

Tissue: Bone

Pathological State: Radiation-induced hematopoietic injury

629
Avicularin Alleviates Osteoporosis in Ovariectomized Mice by Inhibiting Osteoclastogenesis through NF-κB Pathway Inhibition

Q Zhuang, S Chen, W Zhang, M Gu, L Xiao, Y Li, Y Yang, C Feng, H Li, D Geng, Z Wang

Journal of Agricultural and Food Chemistry (ACS Publications) China, 20 December 2022

Osteology

Key words: osteoclast avicularin bone loss NF-κB

Organism: Mouse

Tissue: Bone

630
R158Q and G212S, novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome

Z Li, H Wu, S Wei, M Liu, Y Shi, M Li, N Wang, L Fang, B Xiang, L Gao, C XU, J Zhao

Frontiers of Medicine (Frontiers Media S.A.) China, 19 December 2022

Endocrinology

Key words: Gitelman syndrome, mouse model, compound heterozygous, hypokalemia, Slc12a3

Organism: Mouse

Tissue: Kidney

Pathological State: Gitelman syndrome

631
A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging

H Zhang, Y Guo, J Jiao, Y Qiu, Y Miao, Y He, Z Li, C Xa, L Li, J Cai, K Xu, X Liu, C Zhang, BH Bay, S Song, Y Yang, M Peng, Y Wang, H Fan

Nature Biomedical Engineering (Nature) China, 19 December 2022

Biological Methods

Key words: Biomedical engineering, Magnetic resonance imaging

Organism: Pig

Tissue: Liver

632
Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

PA Goldsteen, AM Sabogal Guaqueta, PPM Mulder, IST Bos, M Eggens, L Van der Koog, JT Soeiro, AJ Halayko, K Mathwig, LEM Kistemaker, EMJ Verpoorte, AM Dolga, R Gosens

Frontiers in Pharmacology (Frontiers Media S.A.) The Netherlands, 18 December 2022

Neuroscience

Key words: asthma, cholinergic, neuron, organ-on-chip, stem cell

Cell Line: Airway cholinergic neurons

633
Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice

STJ Ang, EM Crombie, H Dong, KT Tan, A Hernando, D Yu, S Adamson, S Kim, DJ Withers, H Huang, SY Tsai

Nature Communications (Nature) Singapore, USA, UK, 17 December 2022

Aging

Key words: Ageing, Muscle stem cells, Skeletal muscle

Organism: Mouse

Tissue: Muscle

634
Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10

J Yang, C Hou, H Wang, EA Perez, HC Do-Umehara, H Dong, V Arunagiri, F Tong, M Van Scoyk, M Cho, X Liu, X Ge, RA Winn, KM Ridge, X Wang, NS Chandel, J Liu

Cancer Letters (Elsevier) USA, 17 December 2022

Oncology

Key words: KRAS, Non-small cell lung cancer, Pcdh10, Gene regulation, Miz1

Organism: Mouse

Tissue: Lung

635
FOXM1 increases hTERT protein stability and indicates poor prognosis in gastric cancer

Q Tang, C Liu, S Zhang, L He, Y Liu, J Wang, X Zhao, X Li

Neoplasia (Elsevier) China, 16 December 2022

Oncology

Key words: Gastric cancer, FOXM1, hTERT, ubiquitination, Wnt/β-catenin

Organism: Human

Tissue: Stomach

Pathological State: Cancer

636
Distribution and Toxicity of Submicron Plastic Particles in Mice

TY Tsou, SH Lee, TH Kuo, CC Chien, HC Chen, TJ Cheng

Environmental Toxicology and Pharmacology (Elsevier) Taiwan, 15 December 2022

Toxicology

Key words: Submicron microplastics, Oral gavage, Number concentration, Flow cytometry, Oxidative stress, Inflammation

Organism: Mouse

Tissue: Lung

637
Synergistic cytotoxicity of perifosine and ABT‐737 to colon cancer cells

B Adamová, K Říhová, J Pokludová, P Beneš, J Šmarda, J Navrátilová

Journal of Cellular and Molecular Medicine (Wiley) Czech Republic, 15 December 2022

Oncology

Tissue: Spheroid

Cell Line: HT-29 and HCT-116 human adenocarcinoma cells

638
Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions

M Salzmann, H Platzer, M Mussbacher, M Derler, M Lenz, P Haider, M Brekalo, JB Kral-Pointner, S Kastl, WS Speidl, KT Preissner, U Schubert, M Bischoff, J Wojta, PJ Hohensinner

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Austria, Germany, 10 December 2022

Immunology, Microbiology

Key words: Atherosclerosis, ICAM-1, Extracellular adherence protein, Neutrophils, NET

Organism: Mouse

Tissue: Heart

Pathological State: Staphylococcus aureus Infection

639
Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells

J Chen, J Liu, Z Chen, D Feng, C Zhu, J Fan, S Zhang, X Zhang, J Xu

Virologica Sinica (Elsevier) China, 10 December 2022

Virology

Key words: Myosin IIA (MYH9), Influenza A virus (IAV), vRNP activity, Virus-host interactions, Virus entry

Cell Line: MDCK cells

640
A Proof-of-Concept Preclinical Study Using a Novel Thermal Insulation Device in a Porcine Kidney Auto-Transplantation Model

L Ernst, Z Czigany, P Paschenda, M Schulz, L Breuer, J Kunczik, M Czapli, W Liu, D Jiang, U Klinge, S Djudjaj, P Boor, G Lurje, E Kobayashi, RH Tolba

International Journal of Molecular Sciences (MDPI) Germany, Japan, 09 December 2022

Transplantation Medicine

Key words: kidney transplantation, organ insulation, ischemic reperfusion injury

Organism: Pig

Tissue: Kidney

641
The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer's disease mouse model

CF de Veij Mestdagh, F Koopmans, JC Breiter, JA Timmerman, PC Vogelaar, G Krenning, HD Mansvelder, AB Smit, RH Henning, RE van Kesteren

Alzheimer's Research & Therapy (Springer) The Netherlands, 09 December 2022

Neuroscience

Key words: Alzheimer's disease, APP/PS1 mice, Hibernation-derived compound, SUL-138, Chromanols, Long-term potentiation, Hippocampus-dependent contextual fear memory, Amyloid-beta plaques, Mass-spectrometry, Mitochondria, Fatty acid metabolism

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

642
Angiotensin-converting enzyme 2 in human plasma and lung tissue

J Xie, QF Huang, Z Zhang, Y Dong, H Xu, Y Cao, X Wang, JG Wang

Blood Pressure (Taylor & Francis) China, 09 December 2022

Cardiology

Key words: ACE2, plasma, lung, tissue, hypertension

643
Fumarate hydratase inhibits non‑small cell lung cancer metastasis via inactivation of AMPK and upregulation of DAB2

A Vadhan, YF Yang, YM Wang, PY Chen, SC Tzou, KH Cheng, SCS Hu, TL Cheng, YY Wang, SSF Yuan

Oncology Letters (Spandidos Publications) Taiwan, 09 December 2022

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

644
Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer

K Imamura, Y Tomita, R Sato, T Ikeda, S Iyama, T Jodai, M Takahashi, A Takaki, K Akaike, S Hamada, S Sakata, K Saruwatari, S Saeki, K Ikeda, M Suzuki, T Sakagami

International Journal of Molecular Sciences (MDPI) Japan, USA, 08 December 2022

Oncology

Key words: drebrins, lymphocytes, tumor-infiltrating, lung neoplasms, tumor microenvironment, prognosis

Organism: Human

Tissue: Lung

Pathological State: Cancer

645
Effects of a Phytogenic Supplement Containing Olive By-Product and Green Tea Extracts on Growth Performance, Lipid Metabolism, and Hepatic Antioxidant Capacity in Largemouth Bass (Micropterus salmoides) Fed a High Soybean Meal Diet

J Liu, M Xue, S Morais, M He, H Wang, J Wang, JJ Pastor, RA Gonçalves, X Liang

Antioxidants (MDPI) China, Spain, 07 December 2022

Zoology

Key words: largemouth bass, soybean meal, phytogenic feed additive, antioxidant capacity, lipid metabolism

Organism: Bass Fish

Tissue: Liver

646
Hybrid Transcytosis Nanopomegranates for Sensitizing Breast Cancer Radiotherapy in Deep Tumor Tissue

L Wang, L Xiao, Z Zhao, K Zhong, W Zhu, H Liu, X Li

Nano Research (Scipen) China, 07 December 2022

Oncology

Key words: Breast cancer, transcytosis, hybrid nanopomegranate, hypoxia alleviation, radiosensitization

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

647
HMGB1 Promotes In Vitro and In Vivo Skeletal Muscle Atrophy through an IL-18-Dependent Mechanism

TL Ho, CH Tang, SLY Chang, CH Tsai, HT Chen, CM Su

Cells (MDPI) Taiwan, 06 December 2022

Pharmacology

Key words: HMGB1, IL-18, inflammation, myogenesis, skeletal muscle atrophy

Organism: Mouse

Tissue: Muscle

648
Role of Artificial Intelligence in Cancer Diagnosis and Drug Development

S Srivastava, D Paliwal

Combinatorial Chemistry & High Throughput Screening (Ingenta conect) , 02 December 2022

Oncology

Key words: Cancer, artificial intelligence, computational approach, deep learning, drug development, machine learning

649
Sex-based difference in response to recombinant human bone morphogenetic protein-2 in a rat posterolateral fusion model

JP Foley, EJ Fred, S Minardi, JT Yamaguchi, AC Greene, AA Furman, JG Lyons, JT Paul, TS Nandurkar, KR Blank, RM Havey, M Muriuki, AG Patwardhan, WK Hsu, SR Stock, EL Hsu

Spine (Ingenta conect) USA, 01 December 2022

Key words: BMP, BMP-2, bone, healing, regeneration, rhBMP-2, sex, sex-dependent differences, spinal fusion, spine

650
Tactile cues are important to environmental novelty during repeated open field tests

W Chen, Z Wang, C Ma, X Ma, W Meng, F Yin, Y Yang

Behavioural Processes (Elsevier) China, 30 November 2022

Zoology

Key words: Anxiety, CA1, Environment, Open field test, Repeated testing, Tactile

Organism: Mouse

Tissue: Brain

651
Xenobiotic-induced ribosomal stress compromises dysbiotic gut barrier aging: A one health perspective

J Sun, J Kim, H Jeong, D Kwon, Y Moon

Redox Biology (Elsevier) South Korea, 30 November 2022

Toxicology

Key words: Gut aging, Ribosomal stress, Deoxynivalenol, Gut barrier, Microbiota

Organism: Mouse

Tissue: Small Intestine

652
MiR-140 is involved in T-2 toxin-induced matrix degradation of articular cartilage

Y Shi, X Shao, M Sun, J Ma, B Li, N Zou, F Li

Toxicon (Elsevier) China, 30 November 2022

Toxicology

Key words: miR-140, T-2 toxin, KBD, Articular cartilage, Extracellular matrix

Organism: Mouse

Tissue: Joint Tissue

653
Blockade of c-Met-Mediated Signaling Pathways by E7050 Suppresses Growth and Promotes Apoptosis in Multidrug-Resistant Human Uterine Sarcoma Cells

TT Huang, CM Chen, YW Lan, SS Lin, KB Choo, KY Chong

International Journal of Molecular Sciences (MDPI) Taiwan, USA, Malaysia, 28 November 2022

Pharmacology, Oncology

Key words: E7050, multidrug-resistant uterine sarcoma, apoptosis, cell cycle arrest, c-Met

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

654
The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice

ZD Li, H Li, S Kang, YG Cui, H Zheng, P Wang, K Han, P Yu, YZ Chang

Cell Death & Disease (Nature) China, 28 November 2022

Neuroscience

Key words: Alzheimer's disease, Cognitive ageing

Organism: Mouse

Tissue: Brain

655
Aspirin curcumin ester loaded biomimetic nanodrug improves cognitive deficits in a mouse model of Alzheimer's disease by regulating M1/M2 microglial polarization

Z Li, Z Song, C He, J Fan, W Yu, M Yang, P Li, R Luo, J Zhou, S Xu, B Liu, S Cheng

Materials Today Advances (Elsevier) China, 26 November 2022

Nanomedicine

Key words: Alzheimer's disease, Microglia, Neuroinflammation, Nanoparticle, APP/PS1

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

656
3, 3′-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy

H Tang, K Qin, A Wang, S Li, S Fang, W Gao, M Lu, W Huang, H Zhang, Z Yin

Frontiers in Pharmacology (Frontiers Media S.A.) China, 25 November 2022

Osteology

Key words: 3, 3′-diindolylmethane, osteoarthritis, apoptosis, autophagy, chondrocyte

Organism: Human

Cell Line: Chondrocytes

657
Co-assembled Nanocarriers of De Novo Thiol-Activated Hydrogen Sulfide Donors with an RGDFF Pentapeptide for Targeted Therapy of Non-Small-Cell Lung Cancer

H Chen, X Guan, Q Liu, L Yang, J Guo, F Gao, Y Qi, X Wu, F Zhang, X Tian

ACS Applied Materials & Interfaces (ACS Publications) China, 22 November 2022

Oncology, Nanomedicine

Key words: thiol-activated hydrogen sulfide donors, targeted pentapeptide, coassembled nanocarrier, non-small cell lung cancer, combined radiotherapy

Organism: Mouse

Tissue: Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

658
Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression

D Yang, H Liu, Y Cai, K Lu, X Zhong, S Xing, W Song, Y Zhang, L Ye, X Zhu, T Wang, P Zhang, ST Li, J Feng, W Jia, H Zhang, ST Li, J Feng, W Jia, H Zhang, P Gao

Cell Reports (Cell Press) China, 22 November 2022

Oncology

Key words: branch-chain amino acid, glutamine-depravation, O-GlcNAcylation, HCC progression

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

659
Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling

HC Wang, LY Haung, CJ Wang, YJ Chao, YC Hou, CJ Yen, YS Shan

Journal of Biomedical Science (BMC) Taiwan, 21 November 2022

Oncology

Key words: Hepatocellular carcinoma, Sorafenib resistance, Tumor-associated macrophage, CXCR2, CXCL1, CXCL2

Organism: Human

Tissue: Liver

Pathological State: Cancer

660
Overcoming oxygen heterogeneity of tumor microenvironments to boost cancer immunotherapy by oxygen-switchable ROS/RNS nanogenerators

W Jiang, Z Shen, Z Guo, Q Wang, Q Li, J Hu, Y Wang

Nano Today (Elsevier) China, 21 November 2022

Oncology

Key words: Oxygen-switchable ROS/RNS-releasing polymers, Oxygen heterogeneity, Immunogenic cell death, Cancer immunotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

661
Over-expression of CRTH2 indicates eosinophilic inflammation and poor prognosis in recurrent nasal polyps

W Chen, S He, X Xie, X Yang, C Duan, P Ye, X Li, MG Lawrence, L Borish, X Feng

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 18 November 2022

Pathology

Key words: chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2), chronic rhinosinusitis with nasal polyps, eosinophils, prognosis, recurrent nasal polyp.

Organism: Human

Tissue: Mucosa

Pathological State: Nasal Polyps

662
EBV persistence in gastric cancer cases conventionally classified as EBER-ISH negative

MC Siciliano, S Tornambè, G Cevenini, E Sorrentino, M Granai, G Giovannoni, D Marelli, I Biviano, F Roviello, H Yoshiyama, L Leoncini, S Lazzi, L Mundo

Infectious Agents and Cancer (BMC) Italy, Germany, Japan, Ireland, 17 November 2022

Virology, Oncology

Key words: Gastric adenocarcinoma, Gastric cancer with lymphoid stroma, Epstein Barr Virus, Hit and run mechanism

Organism: Human

Tissue: Stomach

Pathological State: Cancer

663
Formation of the glomerular microvasculature is regulated by VEGFR-3

MD Donnan, DK Deb, T Onay, R Paz Scott, E Ni, Y Zhou, SE Quaggin

American Journal of Physiology (American Physiological Society) USA, 17 November 2022

Physiology

Key words: development, glomerulus, kidney, vascular endothelial growth factor receptor 3, vasculature

Organism: Mouse

Tissue: Kidney

664
Targeting VEGF-A/VEGFR2 Y949 Signaling-Mediated Vascular Permeability Alleviates Hypoxic Pulmonary Hypertension

W Zhou, K Liu, L Zeng, J He, X Gao, X Gu, X Chen, JJ Li, M Wang, D Wu, Z Cai, L Claesson-Welsh, R Ju, J Wang, F Zhang, Y Chen

Circulation (AHA Journals) China, Sweden, 17 November 2022

Cardiology

Key words: single-cell RNA sequencing, smooth muscle, Src family kinase, vascular permeability, hypoxic pulmonary hypertension, VEGF-A, macrophage, VEGFR2 Y949

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Hypertension

665
Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

EM Crombie, S Kim, S Adamson, H Dong, TC Lu, Y Wu, Y Wu, Y Levy, N Stimple, WMR Lam, HWD Hey, DJ Withers, AL Hsu, BH Bay, J Ochala, SY Tsai

Journal of Cachexia, Sarcopenia and Muscle (Wiley) Singapore, USA, Taiwan, UK, Denmark, 17 November 2022

Rheumatology

Organism: Mouse

Tissue: Muscle

666
Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60

Q Guo, M Yin, J Fan, Y Yang, T Liu, H Qian, X Dai, X Wang

Materials & Design (Elsevier) China, 17 November 2022

Nanomedicine

Key words: Glioblastoma, Photothermal therapy, Chemodynamic therapy, Peroxidase-mimicking, HSP60

Organism: Human

Tissue: Brain

Pathological State: Cancer

667
Cbln1 regulates axon growth and guidance in multiple neural regions

P Han, Y She, Z Yang, M Zhuang, Q Wang, X Luo, C Yin, J Zhu, SR Jaffrey, SJ Ji

PLoS Biology (Plos) USA, China, 17 November 2022

Neuroscience

Key words: Axons, Spinal cord, Neurons, Axon guidance, Chemoattractant axon guidance, Retinal ganglion cells, Immunostaining, In situ hybridization

Organism: Mouse

Tissue: Spinal Cord

668
Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer

WJ Cheng, SY Lin, KH Chuang, M Chen, HO Ho, LC Chen, CM Hsieh, MT Sheu

International Journal of Nanomedicine (Taylor & Francis) Taiwan, 16 November 2022

Nanomedicine, Oncology

Key words: docetaxel, pictilisib, nanocarriers, bispecific antibodies, dual epitopes, HER2-positive breast cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

669
Porous scaffold for mesenchymal cell encapsulation and exosome-based therapy of ischemic diseases

A Czosseck, MM Chen, H Nguyen, A Meeson, CC Hsu, CC Chen, TA George, SC Ruan, YY Cheng, PJ Lin, PCH Hsieh, DJ Lundy

Journal of Controlled Release (Elsevier) Taiwan, UK, 14 November 2022

Cardiology, Nanomedicine

Key words: Myocardial infarction, Limb ischemia, Extracellular vesicle, Cell encapsulation, Cell therapy, ExosomeIschemic disease, Cardiac patch

670
Hypothermia evoked by stimulation of medial preoptic nucleus protects the brain in a mouse model of ischaemia

S Zhang, X Zhang, H Zhong, X Li, Y Wu, J Ju, B Liu, Z Zhang, H Yan, Y Wang, K Song, ST Hou

Nature Communications (Nature) China, 12 November 2022

Neuroscience

Key words: Mouse, Stroke

Organism: Mouse

Tissue: Brain

671
Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma

B Yan, L Liu, L Zhao, U Hinz, Y Luo, X An, J Gladkich, C de la Torre, Z Huang, D Schrapel, W Gross, F Fortunato, M Schaefer, MM Gaida, I Herr

Matrix Biology (Elsevier) Germany, 11 November 2022

Oncology, Endocrinology

Key words: Pancreatic cancer, Tumor microenvironment, Pancreatic stellate cells, Collagen type VIII alpha 1 chain, Gemcitabine

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

672
Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice

F Zhang, H Zhen, H Cheng, F Hu, Y Jia, B Huang, M Jiang

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 10 November 2022

Hepathology

Key words: DEHP, liver injury, ferroptosis, endocrine disrupting chemical, pregnancy

Organism: Mouse

Tissue: Liver

673
Response of cadmium adsorption to three-year different agronomic managements in tropical soil: The role of P fractions and Fe oxides

B Liu, C Wei, D Wei, M Chen, W Li, P Pan, B Lin, L Wu, Q Li, Z He

Agriculture, Ecosystems Environment (Elsevier) China, USA, 10 November 2022

Ecology

Key words: Tropical soil, Corn-pepper rotation, Fertilization, Heavy metal, Soil aggregates

Organism: Soil

674
Transthyretin attenuates TDP-43 proteinopathy by autophagy activation via ATF4 in FTLD-TDP

YP Chu, LW Jin, LC Wang, PC Ho, WY Wei, KJ Tsai

Brain (Oxford Academic) Taiwan, USA, 10 November 2022

Cell Biology

Key words: TTR, TDP 43, proteinopathy, ATF4, FTLD

Organism: Mouse

Tissue: Brain

675
Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone cement to repair critical bone defects

S Li, L Zhang, C Liu, J Kim, K Su, T Chen, L Zhao, X Lu, H Zhang, Y Cui, X Cui, F Yuan, H Pan

Bioactive Materials (Elsevier) China, 09 November 2022

Osteology

Key words: Borosilicate glass bone cement, Immunomodulation, Angiogenesis, Osteogenesis

Organism: Rabbit

Tissue: Bone

676
Expression and clinical significance of VISTA, B7-H3, and PD-L1 in glioma

LC Wang, YL Wang, B He, YJ Zheng, HC Yu, ZY Liu, RR Fan, X Zan, RC Liang, ZP Wu, X Tang, GQ Wang, JG Xu, LX Zhou

Clinical Immunology (Elsevier) China, 08 November 2022

Oncology

Key words: VISTA, B7-H3, PD-L1, Glioma, mIF

Organism: Human

Tissue: Brain

Pathological State: Cancer

677
Influence of PRRSV-1 vaccination and infection on mononuclear immune cells at the maternal-fetal interface.

MR Stas, H Kreutzmann, J Stadler, EL Sassu, KH Mair, M Koch, C Knecht, M Stadler, M Dolezal, G Balka, M Zaruba, M Mötz, A Saalmüller, T Rümenapf, W Gerner, A Ladinig

Frontiers in Immunology (Frontiers Media S.A.) Austria, Germany, 08 November 2022

Virology, Immunology

Key words: PRRSV, porcine maternal-fetal interface, NK cells, γδ T cells, B cells, CD4 T cells, CD8 T cells

Organism: Pig

Tissue: Placenta

678
Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia

WC Schrottmaier, JB Kral-Pointner, M Salzmann, M Mussbacher, A Schmuckenschlager, A Pirabe, L Brunnthaler, M Kuttke, B Maier, S Heber, H Datler, Y Ekici, B Niederreiter, U Heber, B Blomgren, AD Gorki, C Söderberg-Nauclé, B Payrastre, MP Gratacap, S Knapp, G Schabbauer, A Assinger

Cell Reports (Cell Press) Austria, Sweden, France, 08 November 2022

Immunology

Key words: platelet, PI3K, p110 inhibitor, streptococcus, pneumonia, infection, inflammation, leukocyte recruitment, immunomodulation

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

679
An Early Islet Transcriptional Signature is Associated with Local Inflammation in Autoimmune Diabetes

AG Derr, A Arowosegbe, B Satish, SD Redick, N Qaisar, Z Guo, E Vanderleeden, MI Trombly, CE Baer, DL Greiner, M Garber, JP Wang

Diabetes (American Diabetes Association) USA, 08 November 2022

Endocrinology

Key words: Type 1 diabets, autoimmune disease/disorders, rat pancreatic islet, virus, single-cell RNA (scRNA) sequencing

Organism: Rat

Tissue: Pancreas

Pathological State: Diabetes Type 1

680
Proteome expression profiling of red blood cells during the tumorigenesis of hepatocellular carcinoma

S Wang, G Wang, S Lu, J Zhang, W Zhang, Y Han, X Cai, Y Zhuang, F Pu, X Yan, Z Tu, L Wang, X Huang, B Fan, D Wang, Z Zhang

Plos one (Plos) China, 08 November 2022

Oncology

Key words: Lung and intrathoracic tumors, Hepatocellular carcinoma, Carcinogenesis, Blood, Biomarkers, Cancer detection and diagnosis, Hemoglobin, Globins

Organism: Human

Tissue: Liver

Pathological State: Cancer

681
Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1, 2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway

Y Zheng, N Gao, W Zhang, R Ma, F Chi, Z Gao, N Cong

Molecular Neurobiology (Springer) China, 05 November 2022

Pharmacology

Key words: Melatonin, Pyroptosis, Cochlear hair cell, Oxygen–glucose deprivation/reperfusion

Cell Line: HEI-OC1 cells

682
Prx1+ MPCs Accumulate in the Dura Mater of Wild‐Type and p21−/− Mice Followed by a Specific Reduction in p21−/− Dural MPCs

SS Shah, PT Salo, FG Lyons, AP Mitha, RJ Krawetz

Advanced Biology (Wiley) Canada, 03 November 2022

Physiology

Organism: Mouse

Tissue: Adipose Tissue

683
Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions

N Yang, Y Wang, Q Tian, Q Wang, Y Lu, L Sun, S Wang, Y Bei, J Ji, H Zhou, W Yang, P Yao, W Zhu, L Sun, Z Huang, X Li, P Shen

Cell Death & Differentiation (Nature) China, USA, 03 November 2022

Cell Biology

Key words: Cell biology, Molecular biology

Organism: Human

Tissue: Adipose Tissue

684
Aberrant Expression of Thymosin Beta-4 Correlates With Advanced Disease and BRAF V600E Mutation in Thyroid Cancer

CY Kuo, JY Jhuang, WC Huang, SP Cheng

Journal of Histochemistry & Cytochemistry (SAGE Journals) Taiwan, 02 November 2022

Oncology, Genetics

685
p38α in the preoptic area inhibits brown adipose tissue thermogenesis

J Wang, S Wu, H Zhan, W Bi, Y Xu, Y Liang, Y Ge, L Peng, X Jin, K Lu, J Zhao, L Gao, Z He

Obesity (Wiley) China, 02 November 2022

Endocrinology

Organism: Mouse

Tissue: Liver, Adipose Tissue

686
Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma

M Mo, X Ma, Y Luo, C Tan, B Liu, P Tang, Q Liao, S Liu, H Yu, D Huang, X Zeng, X Qiu

BMC Cancer (BMC) China, 26 October 2022

Oncology

Key words: Hepatocellular carcinoma, Liver-specific lncRNA, FAM99A, Prognosis, Tumor growth

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

687
Whole-brain mapping of metabolic alterations in a mouse model of Alzheimer's disease by desorption electrospray ionization mass spectrometry imaging

X Wang, X Yang, Z Hou, S Tian, G Xu, J Li, L Wen, D Bi, F Gao, Y Shen, G Huang

Talanta (Elsevier) China, 26 October 2022

Neuroscience

Key words: Alzheimer's disease, Mass spectrometry imaging, Metabolic pathway, Glutamine-glutamate/GABA cycle, Neuronal activity

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

688
A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

L Liang, J Huang, K Cui, P Li, W Shi, F Lin, G Hao, S Sun

International Journal of Molecular Sciences (MDPI) China, 24 October 2022

Immunology, Infectious Diseases

Key words: Salmonella Typhimurium, phage cocktail, immunophage synergy, lysis from without, phage resistance

Organism: Mouse

Tissue: Spleen, Liver, Kidney, Lung

Pathological State: Salmonella Typhimurium Infection

689
Tumor infiltrating CD8/CD103/TIM-3-expressing lymphocytes in epithelial ovarian cancer co-express CXCL13 and associate with improved survival

M Vlaming, V Bilemjian, JÁ Freile, V Melo, A Plat, G Huls, HW Nijman, M de Bruyn, E Bremer

Frontiers in Immunology (Frontiers Media S.A.) The Netherlands, 21 October 2022

Oncology

Key words: CXCL13, RNA-seq, TIM-3, epithelial ovarian cancer, tumor infiltrating lymphocytes

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

690
HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control

R Fardoos, S Nyquist, O Asowata, SW Kazer, A Singh, A Ngoepe, J Giandhari, N Mthabela, D Ramjit, S Singh, F Karim, S Buus, F Anderson, JZ Porterfield, AL Sibiya, R Bipath, K Moodley, W Kuhn, B Berger, S Nguyen, T de Oliveira, T Ndung'u, P Goulder, AK Shalek, A Leslie, HN Kløverpris

Frontiers in Immunology (Frontiers Media S.A.) South Africa, Denmark, USA, UK, 18 October 2022

Immunology

Key words: CD8+ TRM cells, HIV, PD-1, tonsils, exhaustion, natural HIV control

Organism: Human

Tissue: Tonsil

Pathological State: HIV Infection

691
Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment

V Rajeev, DY Fann, QN Dinh, HA Kim, TM De Silva, DG Jo, GR Drummond, CG Sobey, MKP Lai, CLH Chen, TV Arumugam

International Journal of Biological Sciences (Ivyspring International Publisher) Singapore, Australia, South Korea, 17 October 2022

Neuroscience

Key words: Vascular dementia, Vascular cognitive impairment, Intermittent fasting, Neuronal death, White matter lesions, Blood brain barrier breakdown, Chronic cerebral hypoperfusion

Organism: Mouse

Tissue: Brain

692
Nano-integrated Cascade Antioxidase Opsonized by Albumin Bypass the Blood-Brain Barrier for Ischemia-Reperfusion Injury

W Wang, Z Zhang, Y Liu, L Kong, W Li, W Hu, Y Wang, X Liu

Biomaterials Science (Royal Society of Chemistry) China, 17 October 2022

Nanomedicine

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

693
Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains

X Chen, Y Sun, L Chen, X Chen, M Pan, Y Zhang, Q Wang, W Yang, P Yin, D He, X Guo, S Yang, Y Zeng, S Yan, XJ Li, S Li

Cellular and Molecular Life Sciences (Springer) China, 17 October 2022

Neuroscience

Key words: Huntington disease, Neurogenesis, Aging, Neurodegeneration, Primate

Organism: Mouse, Monkey

Tissue: Brain

694
The NQO1/p53/SREBP1 axis promotes hepatocellular carcinoma progression and metastasis by regulating Snail stability

X Wang, Y Liu, A Han, C Tang, R Xu, L Feng, Y Yang, L Chen, Z Lin

Oncogene (Nature) China, 17 October 2022

Oncology

Key words: Cancer metabolism, Tumour angiogenesis, Tumour biomarkers

Organism: Human

Tissue: Liver

Pathological State: Cancer

695
The mesocolic apical fragment in complete mesocolic excision colectomies: should it be analysed separately? A proof‐of‐concept study

C Livadaru, S Morarasu, R Bargaoanu, S Iacob, T Frunza, AM Musina, N Velenciuc, CE Roata, F Zugun-Eloae, D Ferariu, S Lunca, MG Dimofte

Colorectal Disease (Wiley) Romania, 13 October 2022

Gastroenterology

Key words: central lymph nodes, CME, colon cancer, rectal cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

696
Licoricidin combats gastric cancer by targeting the ICMT/Ras pathway in vitro and in vivo

H Ma, F Wu, Y Bai, T Wang, S Ma, L Guo, G Leng, Y Kong, Y Zhang

Frontiers in Pharmacology (Frontiers Media S.A.) China, 13 October 2022

Pharmacology, Oncology

Key words: Licoricidin, gastric cancer, proteomics, ICMT, cancer therapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

697
Disturbances in microbial skin recolonization and cutaneous immune response following allogeneic stem cell transfer

N Bayer, B Hausman, RV Pandey, F Deckert, LM Gail, J Strobl, P Pjevac, C Krall, L Unterluggauer, A Redl, V Bachmayr, L Kleissl, M Nehr, R Kirkegaard, A Makristathis, ML Watzenboeck, R Nica, C Staud, L Hammerl, P Wohlfarth, RC Ecker, S Knapp, W Rabitsch, D Berry, G Stary

Leukemia (Nature) Austria, Australia, 12 October 2022

Immunology, Transplantation Medicine

Key words: Bone marrow transplantation, Immunosurveillance

Organism: Human

Tissue: Skin

698
High Presence of NETotic Cells and Neutrophil Extracellular Traps in Vaginal Discharges of Women with Vaginitis: An Exploratory Study

F Zambrano, A Melo, R Rivera-Concha, M Schulz, P Uribe, F Fonseca-Salamanca, X Ossa, A Taubert, C Hermosilla, R Sánchez

Cells (MDPI) Chile, Germany, 11 October 2022

Reproductive Medicine

Key words: neutrophil extracellular traps, Candida albicans, Trichomonas vaginalis, bacterial vaginosis, infectious vaginitis

Organism: Human

Cell Line: Vaginal smear

699
Quercetin inhibits the amphiregulin/EGFR signaling‐mediated renal tubular epithelial‐mesenchymal transition and renal fibrosis in obstructive nephropathy

Q Wang, F Wang, X Li, Z Ma, D Jiang

Phytotherapy Research (Wiley) China, 11 October 2022

Nephrology

Key words: amphiregulin, epidermal growth factor receptor, epithelial to mesenchymal transition, kidney,quercetin

Organism: Rat

Tissue: Kidney

Pathological State: Renal fibrosis

700
Extracellular Vesicles Derived from Lung Cancer Cells Induce Transformation of Normal Fibroblasts into Lung Cancer-Associated Fibroblasts and Promote Metastasis of Lung Cancer by Delivering lncRNA HOTAIR

X Zhang, Y Zhang, X Qiu, J Cai, Z Yang, F Song

Stem Cells International (Hindawi Publishing Corporation) China, 11 October 2022

Oncology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

701
Lumbrokinase regulates endoplasmic reticulum stress to improve neurological deficits in ischemic stroke

YH Wang, JM Liao, KM Chen, HH Su, PH Liu, YH Chen, YS Tsuei, CF Tsai, SS Huang

Neuropharmacology (Elsevier) Taiwan, 09 October 2022

Neuroscience

Key words: Lumbrokinase, Ischemic stroke, ER stress, IRE1, NLRP3

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

702
Aging-associated REGγ proteasome decline predisposes to tauopathy

J Tu, H Zhang, T Yang, Y Liu, S Kibreab, Y Zhang, L Gao, RE Moses, BWO Malley, J Xiao, Xiaotao Li

Journal of Biological Chemistry (Elsevier) China, 07 October 2022

Neuroscience

Organism: Mouse

Tissue: Brain

703
Spinal cord from body donors is suitable for multicolor immunofluorescence

LF Reissig, G Carrero-Rojas, U Maierhofer, AS Moghaddam, A Hainfellner, B Gesslbauer, T Haider, J Streicher, OC Aszmann, AM Pastor, WJ Weninger, R Blumer

Histochemistry and Cell Biology (Springer) Austria, Spain, 06 October 2022

Biological Methods

Key words: Human spinal cord, Postmortem interval, Multicolor immunofluorescence, Horseradish, Peroxidase immunohistochemistry Neuronal markers

Organism: Human

Tissue: Spinal Cord

704
Interplay between Partial EMT and Cisplatin Resistance as the Drivers for Recurrence in HNSCC

J Ingruber, J Dudas, S Sprung, B Lungu, F Mungenast

Biomedicines (MDPI) Austria, Romania, 05 October 2022

Oncology

Key words: partial EMT, cisplatin resistance, StrataQuest, SCC-25 cells

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

705
Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions

Z Hasan, TQ Nguyen, BWS Lam, JHX Wong, CCY Wong, CKH Tan, VH Thiam, Y Zhang, V Angeli, LN Nguyen

Cellular and Molecular Life Sciences (Springer) Singapore, Bangladesh, 05 October 2022

Neuroscience

Key words: Sphingosine-1-phosphate, S1P transporters, S1P signaling, Neuroinflammation, Multiple sclerosis Lymphocyte egress

Organism: Mouse

Tissue: Brain, Spinal Cord

706
In-situ vaccination using dual responsive organelle targeted nanoreactors

V Sunil, A Mozhi, W Zhan, JH Teoh, PB Ghode, NV Thakor, CH Wang

Biomaterials (Elsevier) Singapore, UK, USA, 04 October 2022

Nanomedicine

Key words: In-situ vaccine, Dual-responsive, Backbone shattering, Combination therapy, Orthotopic glioblastoma mice model, Personalized medicine

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

707
Heart-targeting exosomes from human cardiosphere-derived cells improve the therapeutic effect on cardiac hypertrophy

L Mao, YD Li, RL Chen, G Li, XX Zhou, F Song, C Wu, Y Hu, YX Hong, X Dang, GR Li, Y Wang

Journal of Nanobiotechnology (BMC) China, 04 October 2022

Nanomedicine

Key words: Genetic engineering, Exosomes, Heart homing peptide, Cardiosphere-derived cells, Cardiac hypertrophy

Organism: Rat

Tissue: Heart, Lung, Kidney

Pathological State: Cardiac hypertrophy

708
Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs

L Chen, Y Wang, J Lin, Z Song, Q Wang, W Zhao, Y Wang, X Xiu, Y Deng, X Li, Q Li, X Wang, J Li, X Liu, K Liu, J Zhou, K Li, Y Liu, S Liao, Q Deng, C Xu, Q Sun, S Wu, K Zhang, MX Guan, T Zhou, F Sun, X Cai, C Huang, G Shan

Nature Communications (Nature) China, 01 October 2022

Neuroscience

Key words: Neurophysiology, Non-coding RNAs, Reproductive biology, RNA transport

Organism: Mouse

Tissue: Brain

709
Gut–Brain Axis: Insights from Hippocampal Neurogenesis and Brain Tumor Development in a Mouse Model of Experimental Colitis Induced by Dextran Sodium Sulfate

R Vitali, C Prioreschi, L Lorenzo Rebenaque, E Colantoni, D Giovannini, S Frusciante, G Diretto, F Marco-Jiménez, M Mancuso, A Casciati, S Pazzaglia

International Journal of Molecular Sciences (MDPI) Italy, Spain, 29 September 2022

Developmental Biology

Key words: DSS-induced colitis, brain, neuroinflammation, adult hippocampal neurogenesis, metabolomics, medulloblastoma

Organism: Mouse

Tissue: Brain, Colon

Pathological State: Colitis

710
BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation

CK Wu, MT Wei, HC Wu, CL Wu, CJ Wu, H Liaw, WP Su

Scientific reports (Nature) Taiwan, 29 September 2022

Oncology

Key words: Cancer, Lung cancer, Non-small-cell lung cancer, Oncology

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

711
A novel ceRNA regulatory network involving the long noncoding NEAT1, miRNA-466f-3p and its mRNA target in osteoblast autophagy and osteoporosis

X Zhao, D Zhao, B Geng, W Yaobin, Y Xia

Journal of Molecular Medicine (Springer) China, 28 September 2022

Osteology

Key words: LncRNA NEAT1, MiRNA-466f-3p, HK2, Autophagy, Osteoblast

Organism: Mouse

Tissue: Bone

712
Assessment of traditional Chinese medicine pattern in a bleomycin-induced pulmonary fibrosis mouse model: A pilot study

X Gu, W Wei, Z Liu, F Cao, Z Wu, J Xie, T Wang, Y Jiao

Journal of Traditional Chinese Medical Sciences (Elsevier) China, 28 September 2022

Pulmonology

Key words: Bleomycin, Idiopathic pulmonary fibrosis, Pattern characteristics, Tongue image, Fibrinolytic factor, Inflammatory factor

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary fibrosis

713
Tick feeding modulates the human skin immune landscape to facilitate tick-borne pathogen transmission

J Strobl, V Muendler, S Müller, A Gindl, S Berent, AM Schötta, L Kleissl, C Staud, A Redl, L Unterluggauer, AE Aguilar González, ST Weninger, D Atzmüller, R Klasinc, G Stanek, M Markowicz, H Stockinger, G Stary

The Journal of Clinical Investigation (American Society of Clinical Investigation) Austria, 27 September 2022

Parasitology

Organism: Human

Tissue: Skin

714
Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers

P Gazinska, C Milton, J Iacovacci, J Ward, R Buus, T Alaguthurai, R Graham, A Akarca, E Lips, K Naidoo, J Wesseling, T Marafioti, M Cheang, C Gillett, Y Wu, A Khan, A Melcher, R Salgado, M Dowsett, A Tutt, I Roxanis, S Haider, S Irshad

Clinical Cancer Research (AACR Publications) UK, The Netherlands, Australia, Belgium, 26 September 2022

Oncology, Immunology

Organism: Human

Tissue: Breast

Pathological State: Cancer

715
Azelnidipine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by targeting MEK1/2

L Zhao, Y Zhang, A Li, X Lu, M Li, Q Yuan, N Yang, X Zhao, X Li, Y Jiang, K Liu

Molecular Therapy Oncolytics (Elsevier) China, 26 September 2022

Oncology

Key words: Esophageal squamous cell carcinoma, Azelnidipine, Proliferation, Cell cycle, MEK1/2 inhibitor, MEK1/2-ERK1/2 signaling pathway

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

716
Correlation analysis of tumor purity with clinicopathological, molecular, and imaging features in high-grade gliomas

Q Zhou, P Zhang, J Man, B Zhang, C Xue, X Ke, J Zhou

Neurosurgical Review (Springer) China, 26 September 2022

Oncology, Medical Image Analysis

Key words: High-grade gliomas, Tumor purity, Tumor microenvironment, Neuroimaging

Organism: Human

Tissue: Brain

Pathological State: Cancer

717
Microcystin-leucine-arginine affects brain gene expression programs and behaviors of offspring through paternal epigenetic information

J Xu, W Zhang, S Zhong, X Xie, H Che, W Si, X Tuo, D Xu, S Zhao

Science of The Total Environment (Elsevier) China, 24 September 2022

Developmental Biology

Key words: Paternal epigenetic inheritance, Neurodevelopment in offspring, DNA methylation, Microcystin-LR, Cross-generational effects

Organism: Zebrafish

Tissue: Testis

718
Lithium Treatment Improves Cardiac Dysfunction in Rats Deprived of Rapid Eye Movement Sleep

PH Chen, CC Chung, SH Liu, YH Kao, YJ Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 23 September 2022

Cardiology

Key words: rapid eye movement sleep deprivation, lithium, antifibrosis, cardioprotection

Organism: Rat

Tissue: Heart

Pathological State: Cardiac fibrosis

719
Truncation mutations in MYRF underlie primary angle closure glaucoma

J Ouyang, W Sun, H Shen, X Liu, Y Wu, H Jiang, X Li, Y Wang, Y Jiang, X Xiao, JF Hejtmancik

Human Genetics (Springer) China, USA, 21 September 2022

Ophthalmology

Organism: Mouse

Tissue: Eye

720
Lenvatinib synergistically promotes radiotherapy in hepatocellular carcinoma by inhibiting Src/STAT3/NF-κB-mediated epithelial–mesenchymal transition and metastasis

YS Weng, IT Chiang, JJ Tsai, YC Liu, FT Hsu

International Journal of Radiation Oncology*Biology*Physics (Elsevier) Taiwan, 19 September 2022

Oncology, Radiotherapy

Key words: Radiotherapy, lenvatinib, Src, epithelial–mesenchymal transition, hepatocellular carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

721
Phosphorus fractions and iron oxides responsible for the variations in the Cd retention capacity in tropical soil aggregates under different cropping patterns

D Wei, C Wei, P Pan, B Lin, L Wu, B Liu, Z He

Journal of Hazardous Materials (Elsevier) China, USA, 19 September 2022

Ecology

Key words: Cadmium, Tropical soil aggregates, Adsorption characteristics, P fractions, Fe oxides

Organism: Soil

722
FDX1 expression predicts favourable prognosis in clear cell renal cell carcinoma identified by bioinformatics and tissue microarray analysis

X Huang, T Wang, J Ye, H Feng, X Zhang, X Ma, B Wang, Y Huang, X Zhang

Frontiers in Genetics (Frontiers Media S.A.) China, 16 September 2022

Oncology

Key words: ferredoxin 1, clear cell renal cell carcinoma, cuproptosis, metastasis, tumourigenesis, tissue microarray analyses, prognostic biomarker

Organism: Human

Tissue: Kidney

Pathological State: Cancer

723
A neurogenic signature involving monoamine Oxidase-A controls human thermogenic adipose tissue development

J Solivan-Rivera, ZY Loureiro, T DeSouza, A Desai, S Pallat, Q Yang, R Rojas-Rodriguez, R Ziegler, P Skritakis, S Joyce, D Zhong, T Nguyen, S Corvera

Elife (eLife Sciences Publications) USA, 15 September 2022

Developmental Biology

Organism: Human

Tissue: Adipose Tissue

724
Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells

G Zou, J Xia, H Luo, D Xiao, J Jin, C Miao, X Zuo, Q Gao, Z Zhang, T Xue, Y You, Y Zhang, W Xiong

Nature Metabolism (Nature) China, USA, 15 September 2022

Neuroscience, Toxicology

Key words: Cerebellum, Ion channels in the nervous system, Metabolism, Neurophysiologym

Organism: Mouse

Tissue: Brain

725
Penicillium digitatum, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient

I Iturrieta-González, A Giacaman, P Godoy-Martínez, F Vega, M Sepúlveda, C Santos, V Toledo, G Rivera, L Ortega, A San Martín, V Bahamondes, F Collao, R Sánchez, F Fonseca-Salamanca

Journal of Fungi (MDPI) Chile, 14 September 2022

SARS-CoV-2, Immunology

Key words: Penicillium digitatum, COVID-19, pulmonar infection, pneumonia

Cell Line: Penicillium digitatum fungal culture

726
Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren's syndrome

N Kaneko, H Chen, CA Perugino, T Maehara, R Munemura, S Yokomizo, J Sameshima, TJ Diefenbach, KR Premo, A Chinju, Y Miyahara, M Sakamoto, M Moriyama, JH Stone, S Nakamura, S Pillai

Scientific Reports (Nature) USA, Japan, 14 September 2022

Immunology, Rheumatology

Key words: Diseases, Immunology, Pathogenesis, Rheumatology

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's syndrome

727
ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model

YY Wang, AC Hung, YC Wu, S Lo, HD Chen, YK Chen, YC Hsieh, SCS Hu, MF Hou, SSF Yuan

Scientific Reports (Springer) Taiwan, UK, 14 September 2022

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

728
Ultrasmall zirconium carbide nanodots for synergistic photothermal-radiotherapy of glioma

M Yin, X Chen, Q Guo, L Xiao, P Gao, D Zang, J Dong, Z Zha, X Dai, X Wang

Nanoscale (Royal Society of Chemistry) China, 13 September 2022

Nanomedicine, Radiotherapy

729
Visualization of macrophage subsets in the development of the fetal human inner ear

C Steinacher, LJ Chacko, Wei Liu, H Rask-Andersen, W Bader, J Dudas, CM Sergi, T Dhanaseelan, N Moreno, R Glueckert, R Hoermann, A Schrott-Fischer

Frontiers in Immunology (Frontiers Media S.A.) Austria, Sweden, Canada, UK, 09 September 2022

Developmental Biology

Key words: fetal human inner ear, macrophages, development, IBA-1, CD45, CD68, CD163, CX3CL1

Organism: Human

Tissue: Embryo

730
In utero arsenic exposure increases DNA damage and gene expression changes in umbilical cord mesenchymal stem cells (UC-MSCs) from newborns as well as in UC-MSC differentiated hepatocytes

S Kantisin, K Chaisatra, P Hunsonti, V Parnlob, P Navasumrit, M Ruchirawat

Toxicology Reports (Elsevier) Thailand, 07 September 2022

Toxicology, Reproductive Medicine

Key words: Arsenic, In utero exposure, 8-OHdG, 8-nitroguanine, Mesenchymal stem cells

Cell Line: Human mesenchymal stem cells

731
Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial.

OL Filip, AG Mocanu, IA Neacsu, MV Ciocilteu, G Rau, J Neamtu

Current Health Sciences Journal (EBSCO) Romania, 05 September 2022

Tissue Engineering

Cell Line: Collagen Matrix

732
Interleukin-4 receptor alpha signaling regulates monocyte homeostasis.

P Haider, JB Kral-Pointner, M Salzmann, F Moik, S Bleichert, WC Schrottmaier, C Kaun, M Brekalo, MB Fischer, WS Speidl, C Hengstenberg, BK Podesser, K Huber, I Pabinger, S Knapp, F Brombacher, C Brostjan

The FASEB Journal (Wiley) Austria, 05 September 2022

Immunology

Key words: homeostasis, immunity, innate, interleukin-4, monocytes, receptors, signal transduction

Organism: Mouse

Tissue: Spleen

733
Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection

N Vaquero-Siguero, N Schleussner, J Volk, M Mastel, J Meier, R Jackstadt

Cancers (MDPI) Germany, 31 August 2022

Oncology

Key words: colorectal cancer, metastasis, mouse models, mouse-derived organoids, orthotopic transplantation, tumor heterogeneity, clonal selection, niche

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

734
PPsNet: An Improved Deep Learning Model for Microsatellite Instability High Prediction in Colorectal Cancer from Whole Slide Images

J Lou, J Xu, Y Zhang, Y Sun, A Fang, J Liu, LAJ Mur, B Ji

Computer Methods and Programs in Biomedicine (Elsevier) China, UK, 31 August 2022

Medical Image Analysis

Key words: Colorectal cancer, Microsatellite instability, Deep learning, Deep supervision, Pair-wise learning, Synergic network, Parameter sharing, Whole slide images

Organism: Human

Tissue: Colon

Pathological State: Cancer

735
Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

SJF Cronin, S Rao, MA Tejada, BL Turnes, S Licht-Mayer, T Omura, C Brenneis, E Jacobs, L Barrett, A Latremoliere, N Andrews, KM Channon, A Latini, AC Arvanites, LS Davidow, M Costigan, LL Rubin, JM Penninger, CJ Woolf

Science Translational Medicine (Science) Austria, USA, UK, Brazil, 31 August 2022

Pharmacology, Oncology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

736
Identification and validation of a poor clinical outcome subtype of primary prostate cancer with Midkine abundance

Q Zhou, C Yang, Z Mou, S Wu, X Dai, X Chen, Y Ou, L Zhang, J Sha, H Jiang

Cancer Science (Wiley) China, 26 August 2022

Oncology

Organism: Human

Tissue: Prostate

Pathological State: Cancer

737
P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma

V Arnaud-Sampaio, C Bento, T Glaser, E Adinolfi, H Ulrich, C Lameu

Frontiers in Oncology (Frontiers Media S.A.) Brazil, Italy, 25 August 2022

Pharmacology, Oncology

Key words: P2X7 receptor isoforms, chemoresistance, childhood cancer, cancer, drug efflux, cancer stem cells, autophagy, epithelial-mesenchymal transition

Cell Line: ACN human neuroblastoma cells

738
KI Essence extract (a spleen-tonifying formula) promotes neurite outgrowth, alleviates oxidative stress and hypomyelination, and modulates microbiome in maternal immune activation offspring

GA Lee, HW Zhao, YW Chang, CJ Lee, YSH Yang, YC Wu, WL Lin, YR Liu, DS Ning, SH Tseng

Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan, 25 August 2022

Pharmacology

Key words: mushroom, maternal immune activation, myelination, microbiota, oxidative stress, spleen-tonifying formula

Organism: Rat

Tissue: Brain

739
Thymidine and 2′-deoxyuridine reduce microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35 induced brain injury

M Liu, M Zeng, S Wang, B Cao, P Guo, Y Zhang, J Jia, Q Zhang, B Zhang, R Wang, J Li, X Zheng, W Feng

Archives of Biochemistry and Biophysics (Elsevier) China, 24 August 2022

Neuroscience

Key words: Thymidine, 2′-deoxyuridine, Glycolytic metabolism, Microglia activation, Oxidative stress, Brain injury

Organism: Mouse

Tissue: Brain

Pathological State: Aβ25-35-induced brain injury

740
Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC.

K Li, Y Gong, D Qiu, H Tang, J Zhang, Z Yuan, Y Huang, Y Qin, L Ye, Y Yang

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 24 August 2022

Oncology

Key words: Immunity, Innate, Immunotherapy, Liver Neoplasms, Lymphocytes, Tumor-Infiltrating, Tumor Microenvironment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

741
The medial wall and medial compartment of the cavernous sinus: an anatomic study using plastinated histological sections

K Shi, Z Li, X Wu, C Ma, X Zhu, L Xu, Z Sun, S Xu, L Liang

Neurosurgical Review (Springer) China, 19 August 2022

Neuroscience

Key words: Cavernous sinus, Medial wall, Dura mater, Plastination

Organism: Human

Tissue: Bone

742
Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae

ZY Chen, YC Yang, BJ Wang, FY Cheng, YL Lee, YH Lee, YJ Wang

Ecotoxicology and Environmental Safety (Elsevier) Taiwan, 17 August 2022

Toxicology, Zoology

Key words: Zinc oxide nanoparticles (ZnONPs, Danio rerio, Surface modification, Liver toxicity, Developmental changes, Autophagy

Organism: Zebrafish

Tissue: Embryo

743
TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma

S Hu, H Lu, W Xie, D Wang, Z Shan, X Xing, XM Wang, J Fang, W Dong, W Dai, J Guo, Y Zhang, S Wen, XY Guo, Q Chen, F Bai, Z Wang

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 16 August 2022

Oncology, Immunology

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

744
Papillary Renal Neoplasm with Reverse Polarity—a Comparative Study with CCPRCC, OPRCC, and PRCC1

T Wang, X Ding, X Huang, J Ye, H Li, S Cao, Y Gao, X Ma, Q Huang, B Wang

Human Pathology (Elsevier) China, 14 August 2022

Nephrology

Key words: Papillary renal neoplasm with reverse polarity, Papillary renal cell carcinoma type 1, Clear cell papillary renal cell carcinoma, Oncocytic papillary renal cell carcinoma, Whole exon sequencing, KRAS

Organism: Human

Tissue: Kidney

Pathological State: Cancer

745
Comparison of H7N9 and H9N2 influenza infections in mouse model unravels the importance of early innate immune response in host protection

C Zhu, M Zhang, Y He, Y Yang, L Zhang, S Zuan, L Jiang, J Xu, X Zhang

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) China, 12 August 2022

Virology, Immunology

Key words: H7N9, H9N2, pathological characteristics, C57BL/6 mice, lung

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection

746
Stereotaxic atlas of the infant rat brain at postnatal days 7–13

YN Chen, X Zheng, HL Chen, JX Gao, XX Li, JF Xie, YP Xie, K Spruyt, YF Shao, YP Hou

Frontiers in Neuroanatomy (Frontiers Media S.A.) China, France, 12 August 2022

Neuroscience, Developmental Biology

Key words: infant rat, brain, atlas, stereotaxic coordinates, neural development

Organism: Rat

Tissue: Brain

747
Short-Term Cortical Electrical Stimulation during the Acute Stage of Traumatic Brain Injury Improves Functional Recovery

LC Wang, WY Wei, PC Ho

Biomedicines (MDPI) Taiwan, 12 August 2022

Neuroscience

Key words: traumatic brain injury, neural stem cells, cortical electrical stimulation, functional recovery

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

748
Preclinical Therapeutic Evaluation of Lenvatinib-Eluting Microspheres for Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

J Pe, B Choi, H Choi, SW Kwon, DH Kim

CardioVascular and Interventional Radiology (Springer) USA, 12 August 2022

Oncology

Key words: Transcatheter arterial chemoembolization, Hepatocellular carcinoma, Lenvatinibm, Drug eluting microspheres, Local drug delivery

Organism: Rat

Tissue: Lung, Heart, Kidney

Pathological State: Cancer

749
Effects of Cordyceps militaris fermentation products on reproductive development in juvenile male mice

S Lin, WK Hsu, MS Tsai, TH Hsu, TC Lin, HL Su, SH Wang, D Jin

Scientific Reports (Nature) China, Taiwan, 12 August 2022

Nutritional science

Key words: Nutrition, Quality of life

Organism: Mouse

Tissue: Testis

750
m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs

F Niu, P Che, Z Yang, J Zhang, L Yang, M Zhuang, X Ou, SJ Ji

iScience (Cell Press) China, 11 August 2022

Ophthalmology

Key words: m6A, YTHDF1, YTHDF2, YTHDF3, Cortical neurogenesis, Retinal neurogenesis

Organism: Mouse

Tissue: Embryo

751
Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice

P Guo, M Zeng, B Cao, M Liu, Y Zhang, J Jia, Q Zhang, B Zhang, R Wang, W Xiong, X Zheng, W Feng

Journal of Functional Foods (Elsevier) China, 11 August 2022

Gastroenterology

Key words: Alzheimer's disease, Camellia oil, Gut microbiota, Lipid metabolism, PPARs

Organism: Mouse

Tissue: Brain

752
Disulfiram increases the efficacy of 5-fluorouracil in organotypic cultures of colorectal carcinoma

M Hendrych, K Říhová, B Adamová, V Hradil, M Stiborek, P Vlček, M Hermanová, J Vašíčková, P Beneš, J Šmarda, V Kanický, J Preisler, J Navrátilová

Biomedicine & Pharmacotherapy (Elsevier) Czech Republic, 10 August 2022

Oncology

Key words: Disulfiram/copper, 5-fluorouracil, Synergism, Organotypic culture, Spheroid, Colorectal carcinoma

Organism: Spheroid

Cell Line: HT-29 and HCT-116 human adenocarcinoma cells

753
Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus

M Sangesland, AT de la Peña, S Boyoglu-Barnum, L Ronsard, F Amokrane Nait Mohamed, T Bracamonte Moreno, RM Barnes, N Lonberg, M Ghebremichael, M Kanekiyo, A Ward, D Lingwood

Immunity (Cell Press) USA, 10 August 2022

Immunology

Key words: influenza virus, universal, B cell, vaccine, broad, antibody gene polymorphism, autoreactivityt, olerance

Cell Line: Hep2 cell

754
Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma

H Zhang, N Zhang, W Wu, Z Wang, Z Dai, X Liang, L Zhang, Y Peng, P Luo, J Zhang, Z Liu, Q Cheng, Z Liu

iScience (Cell Press) China, 10 August 2022

Oncology, Immunology

Key words: Immunology, Biocomputational method, Genomic analysis, Cancer

Organism: Human

Tissue: Brain

Pathological State: Cancer

755
Club cells employ regeneration mechanisms during lung tumorigenesis

Y Chen, R Toth, S Chocarro, D Weichenhan, J Hey, P Lutsik, S Sawall, GT Stathopulos, C Plass, R Sotillo

Nature Communications (Nature) Germany, 05 August 2022

Oncology

Key words: Cancer models, Cancer stem cells, Lung cancer, Mechanisms of disease

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

756
Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest

C Li, Y Feng, Z Fu, J Deng, Y Gu, H Wang, X Wu, Z Huang, Y Zhu, Z Liu, M Huang, T Wang, S Hu, B Yao, Y Zeng, CJ Zhou, SDM Brown, Y Liu, A Vidal-Puig, Y Dong, Y Xu

Cell death Discovery (Nature) China, USA, UK, 02 August 2022

Cell Biology

Key words: Cell biology, Development

Organism: Mouse

Tissue: Testis

757
Alleviating experimental allergic eye disease by inhibiting pro-lymphangiogenic VEGFR3 signal

B Lou, W Wu, L Zeng, W Zhou, X Zhang, X Zhou, Z Liu, K Liu, X Gu, X Chen, Y Wang, Y Chen, X Gao, F Zhang

The Ocular Surface (Elsevier) China, 02 August 2022

Ophthalmology

Key words: Allergic eye disease, Lymphatics, Vegfr3, CD4+ T cell, Lymph node

Organism: Mouse

Tissue: Eye, Small Intestine

Pathological State: Allergy

758
Intermittent hilar occlusion attenuates or prevents renal ischaemia-reperfusion in mice

L Wang, C Peng, J Chen, H Li, Q Jiao, Z Zhang, L Wang, Q Yuan, B Wang, Y Huang, X Ma

Biomedicine & Pharmacotherapy (Elsevier) China, 01 August 2022

Nephrology

Key words: Partial nephrectomy, Ischaemia-reperfusion injury, Oxidative damage, Laboratory animal models

Organism: Mouse

Tissue: Kidney

Pathological State: Renal fibrosis

759
Sulfur mustard single-dose exposure triggers senescence in primary human dermal fibroblasts

G Horn, C Schäfers, H Thiermann, S Völkl, A Schmidt, S Rothmiller

Archives of Toxicology (Springer) Germany, 29 July 2022

Toxicology

Key words: Sulfur mustard, Senescence, Human dermal fibroblasts, Wound healing disorder

Cell Line: Human primary dermal fibroblasts

760
A Chinese medical nutrition therapy diet accompanied by intermittent energy restriction alleviates type 2 diabetes by enhancing pancreatic islet function and and regulating gut microbiota composition

W Luo, J Zhou, X Yang, R Wu, H Liu, H Shao, B Huang, X Kang, L Yang, D Liu

Food Research International (Elsevier) China, 28 July 2022

Gastroenterology, Endocrinology

Key words: Type 2 diabetes, Diet, Intermittent energy restriction, Chinese Medical Nutrition Therapy, Pancreatic islet function, Gut microbiota

Organism: Mouse

Tissue: Pancreas

761
A Natural Gas Fermentation Bacterial Meal (FeedKind®) as a Functional Alternative Ingredient for Fishmeal in Diet of Largemouth Bass, Micropterus salmoides

B Guo, X He, C Ge, M Xue, J Wang, M Longshaw, J Wang, X Liang

Antioxidants (MDPI) China, UK, 28 July 2022

Zoology

Key words: largemouth bass, methanotroph (Methylococcus capsulatus, Bath) bacteria meal (FeedKind®), growth performance, antioxidant capacity, intestinal health

Organism: Bass Fish

Tissue: Small Intestine

762
Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial

OL Filip, AG Mocanu, IA Neascsu, MV Ciocilteu, G Rau, J Neamtu

Current Health Sciences Journal (Medical University Publishing House Craiova) Romania, 28 July 2022

Biomaterials

Key words: Biocomposite, collagen-hydroxyapatite, biocompatibility

763
High Glucose Aggravates Retinal Endothelial Cell Dysfunction by Activating the RhoA/ROCK1/pMLC/Connexin43 Signaling Pathway

H Zhao, H Kong, W Wang, T Chen, Y Zhang, J Zhu, D Feng, Y Cui

Investigative Ophthalmology & Visual Science (ARVO Journals) China, 26 July 2022

Ophthalmology

Key words: diabetic retinopathy, retinal vascular endothelial cells, RhoA/ROCK1/pMLC signaling, ROCK inhibitor, connexin43

Organism: Mouse

Tissue: Eye

764
Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 Macrophages through PI3K/Akt/mTOR Signaling Pathway

T Zhang, Y Zhang, Z Yang, Y Jiang, L Sun, D Huang, M Tian, Y Shen, J Dang, J Hou, Y Ma

Pathogens and Global Health (Taylor & Francis) China, 25 July 2022

Immunology

Key words: Echinococcus multilocularis, glycolysis, macrophage polarization, protoscoleces, PI3K/Akt/mTOR

Organism: Human

Tissue: Liver

Pathological State: Echinococcus Infection

765
Tegaserod Maleate Suppresses the Growth of Gastric Cancer In Vivo and In Vitro by Targeting MEK1/2

Z Wang, Y Chen, X Li, Y Zhang, X Zhao, H Zhou, X Lu, L Zhao, Q Yuan, Y Shi, J Zhao, Z Dong, Y Jiang, K Liu

Cancers (MDPI) China, 23 July 2022

Oncology

Key words: gastric cancer, tegaserod maleate, MEK1, MEK2, chemoprevention

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

766
Autologous exosome facilitates load and target delivery of bioactive peptides to repair spinal cord injury

N Ran, W Li, R Zhang, C Lin, J Zhang, Z Wei, Z Li, Z Yuan, M Wang, B Fan, W Shen, X Li, H Zhou, X Yao, X Kong, S Feng

Bioactive Materials (Elsevier) China, 22 July 2022

Neuroscience

Key words: Spinal cord injury, Targeted repair, Autologous plasma exosome, Drug loading, Axon regeneration

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

767
Rice co-expression network analysis identifies gene modules associated with agronomic traits

Y Zhang, E Han, Y Peng, Y Wang, Y Wang, Z Geng, Y Xu, H Geng, Y Qian, S Ma

Plant Physiology (Oxford Academic) China, 22 July 2022

Agricultural Science

Organism: Rice

768
miR-429 negatively regulates the progression of hypoxia-induced retinal neovascularization by the HPSE-VEGF pathway

H Xu, B Yang, Z Ren, D Wu, A Hu, J Hu

Experimental Eye Research (Elsevier) China, 22 July 2022

Ophthalmology

Key words: Neovascularization, Heparanase, miR-429, Retinopathy, VEGF

Organism: Mouse

Tissue: Eye

769
Hexavalent chromium exposure induces intestinal barrier damage via activation of the NF-κB signaling pathway and NLRP3 inflammasome in ducks

C Xing, F Yang, J Shan, X Yi, F Ali, Y Zhu, C Wang, C Zhang, Y Zhuang, H Cao, G Hu

Frontiers in Immunology (Frontiers Media S.A.) China, Pakistan, 22 July 2022

Zoology

Key words: hexavalent chromium, intestinal barrier, NF-κB, NLRP3, duck

Organism: Duck

Tissue: Small Intestine

770
Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter's Trans-Formed DLBCL and Germinal Center B-Cells

B Uhl, KT Prochazka, K Pansy, K Wenzl, J Strobl, C Baumgartner, MM Szymra, JE Waha, A Wolf, PV Tomazic, E Steinbauer, M Steinwender, S Friedl, M Weniger, R Küppers, M Pichler, HT Grenix, G Stary, AG Ramsay, B Apollonio

International Journal of Molecular Sciences (MDPI) Austria, Germany, 17 July 2022

Oncology

Key words: diffuse large B-cell lymphoma, Richter syndrome, transformed follicular lymphoma, chemokine receptors, CCR7, CCL19, CCL21

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

771
MiRNA-Mediated Fibrosis in the Out-of-Target Heart following Partial-Body Irradiation

B Tanno, F Novelli, S Leonardi, C Merla, G Babini, P Giardullo, M Kadhim, D Traynor, DKR Medipally, AD Meade, FM Lyng, S Tapio, L Marchetti, A Saran, S Pazzaglia, M Mancuso

Cancers (MDPI) Italy, UK, Ireland, Germany, 16 July 2022

Cardiology

Key words: miRNome, Raman spectroscopy, abscopal effect, cardiac fibrosis, miR-1, mir-133a

Organism: Mouse

Tissue: Heart

772
LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer

Z Sun, R Zhang, X Zhang, Y Sun, P Liu, N Francoeur, L Han, WY Lam, Z Yi, R Sebra, M Walsh, J Yu, W Zhang

Molecular Cancer (Springer) USA, China, 16 July 2022

Oncology

Key words: LINE-1, Transposable element, NSCLC, LUSC, LUAD, FGGY, Metabolic

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

773
Suppression of Allergic Asthma by Loss of Function of Miz1-Mediated Th1 Skewing

HC Do-Umehara, C Chen, Q Zhang, RP Schleimer, GRS Budinger, J Liu

American Journal of Respiratory Cell and Molecular Biology (ATS Journals) USA, 14 July 2022

Allergy Research

Key words: Asthma, Gene regulation, Th1/Th2 immunity, Miz1, IL-12

774
The prostate tissue‐based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy

CM Heaphy, CE Joshu, JR Barber, C Davis, J Lu, R Zarinshenas, E Giovannucci, LA Mucci, MJ Stampfer, M Han, AM De Marzo, TL Lotan, EA Platz, AK Meeker

The Journal of Pathology: Clinical Research (Wiley) USA, 14 July 2022

Oncology

Organism: Human

Tissue: Prostate

Pathological State: Cancer

775
Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice

YC Shyu, PC Liao, TS Huang, CJ Yang, MJ Lu, SM Huang, XY Lin, CC Liou, YH Kao, CH Lu, HL Peng, JR Chen, WJ Cherng, NI Yang, YC Chen, HC Pan, ST Jiang, CC Hsu, G Lin, SS Yuan, PWC Hsu, KJ Wu, TL Lee, CKJ She

Advanced Science (Wiley) Taiwan, 13 July 2022

Aging

Organism: Mouse

Tissue: Heart

Pathological State: Tissue Fibrosis

776
Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC)

Z Hui, J Zhang, Y Ren, X Li, C Yan, W Yu, T Wang, S Xiao, Y Chen, R Zhang, F Wei, J You, X Ren

Cell Death & Disease (Nature) China, 13 July 2022

Oncology

Key words: Cancer immunotherapy, Cancer microenvironment, Non-small-cell lung cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

777
The Interplay of NEAT1 and miR-339-5p Influences on Mesangial Gene Expression and Function in Various Diabetic-Associated Injury Models

S Reichelt-Wurm, M Pregler, T Wirtz, M Kretz, K Holler, B Banas, MC Banas

Non-Coding RNA (MDPI) Germany, 13 July 2022

Endocrinology, Genetics

Key words: NEAT1, has-miR-339-5p, diabetic kidney disease, mesangial cell, lncRNA, miRNA

Cell Line: Human mesangial cells

778
Pharmacologic modulation of intracellular Na+ concentration with ranolazine impacts inflammatory response in humans and mice

M Lenz, M Salzmann, CI Ciotu, C Kaun, KA Krychtiuk, A Rehberger Likozar, M Sebestjen, L Goederle, S Rauscher, Z Krivaja, CJ Binder, K Huber, C Hengstenberg, BK Podesser, MJM Fischer, J Wojta, PJ Hohensinner, WS Speidl

PNAS (United States National Academy of Sciences) Austria, Slovenia, 13 July 2022

Immunology

Key words: Inflammation, Atherosclerosis, Endothelium, NF-κB, Ranolazine

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerotic plaques

779
CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection

OO Baiyegunhi, J Mann, T Khaba, T Nkosi, Anele Mbatha, F Ogunshola, C Chasara, N Ismail, T Ngubane, I Jajbhay, J Pansegrouw, KL Dong, BD Walker, T Ndung'u, ZM Ndhlovu

Nature Communications (Nature) South Africa, USA, Germany, UK, 12 July 2022

Immunology, Virology

Key words: HIV infections, Lymph node, Retrovirus

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

780
Angiotensin-Converting Enzyme 2 Potentiates SARS-CoV-2 Infection by Antagonizing Type I Interferon Induction and Its Down-Stream Signaling Pathway

J Chen, J Liu, Z Chen, H Peng, C Zhu, D Feng, S Zhang, P Zhao, X Zhang, J Xu

mSphere (ASM Journals) China, 12 July 2022

Immunology, SARS-CoV-2

Pathological State: Covid-19

Cell Line: A549, HEK293T, NCI-H1299, and Vero E6 cell lines

781
MicroRNA-21-5p promotes mucosal type 2 inflammation via regulating GLP1R/IL-33 signaling in chronic rhinosinusitis with nasal polyps

G Luan, M Wang, J Yuan, X Bu, Y Wang, S Ying, C Wang, L Zhang

Journal of Allergy and Clinical Immunology (Elsevier) China, 11 July 2022

Allergy Research

Key words: Chronic rhinosinusitis with nasal polyps, Glucagon-like peptide-1 receptor, MicroRNA-21-5p, Type 2 inflammation

Organism: Human

Tissue: Mucosa

Pathological State: chronic rhinosinusitis

782
Molecular species of oxidized phospholipids in brain differentiate between learning-and memory impaired and unimpaired aged rats

MS Narzt, C Kremslehner, B Golabi, IM Nagelreiter, J Malikovic, AM Hussein, R Plasenzotti, V Korz, G Lubec, F Gruber, J Lubec

Amino Acids (Springer) Austria, Egypt, 11 July 2022

Neuroscience

Key words: Prefrontal cortex, Memory, Phospholipids, Learning

Organism: Rat

Tissue: Brain

783
The immune microenvironment features and response to immunotherapy in EBV-associated lymphoepithelioma-like cholangiocarcinoma

NJ Chiang, YC Hou, KT Tan, HW Tsai, YJ Lin, YC Yeh, LT Chen, YF Hou, MH Chen, YS Shan

Hepatology International (Springer) Taiwan, 03 July 2022

Hepathology

Key words: Intrahepatic cholangiocarcinoma, Epstein–Barr virus, Lymphoepithelioma-like cholangiocarcinoma, Tumor immune microenvironment, Adaptive immune response, T cells, Macrophages, PD-1, PD-L1, Immune checkpoint blockade

Organism: Human

Tissue: Liver

Pathological State: Cancer

784
The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes

B Mahlobo, F Laher, W Smidt, F Ogunshola, T Khaba, T Nkosi, A Mbatha, T Ngubane, K Dong, I Jajbhay, J Pansegrouw, ZM Ndhlovu

BMC Immunology (BMC) South Africa, USA, 01 July 2022

Immunology

Key words: Follicular regulatory T cells (TFRs), Follicular helper T (TFH) cells, Lymph node, Biomarkers, HIV

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

785
Mutations in GCK May Lead to MODY2 by Reducing Glycogen Synthesis

Z Li, K Li, Y Sun, X Jiang, J Liu, J Li, L Fang, G Li, Q Guan, C Xu

Advanced Biology (Wiley) China, 30 June 2022

Endocrinology

Cell Line: HepG2 cells

786
Long-Molecule Assessment of Ribosomal DNA and RNA

Z Ahmad

(Queen Mary University of London) UK, 30 June 2022

Bioimaging

Organism: Human

Cell Line: Human Lymphoblastoid Cell Lines

787
An optimized method for obtaining clinical‐grade specific cell subpopulations from human umbilical cord‐derived mesenchymal stem cells

Y Jia, A Wang, B Zhao, C Wang, R Su, B Zhang, Z Fan, Q Zeng, L He, X Pei, W Yue

Cell Proliferation (Wiley) China, 29 June 2022

Biological Methods

Organism: Human

Cell Line: hUC-MSCs

788
The long-term survival and functional maturation of human iNPC-derived neurons in the basal forebrain of cynomolgus monkeys

S Feng, T Zhang, W Ke, Y Xiao, Z Guo, C Lu, S Li, Z Guo, Y Liu, G Tan, Y Chen, F Yue, Y Shu, C Yue, N Jing

Life Medicine (Oxford Academic) China, 28 June 2022

Stem Cell Research, Neuroscience

Key words: Non-human primates, Cerebral cell transplantation, Human induced neural stem/progenitor cells, Neuronal differentiation, Functional maturation

Organism: Monkey

Tissue: Brain

789
Hepatitis B virus X gene impacts on the innate immunity and immune‐tolerant phase in chronic hepatitis B virus infection

KC Chang, HH Chua, YH Chen, DJ Tsuei, MH Lee, CL Chiang, YM Jeng, JF Wu, HL Chen, HY Hsu, YH Ni, MH Chang

Liver International (Wiley) Taiwan, 28 June 2022

Hepathology, Immunology

Organism: Human

Tissue: Liver

Pathological State: Chronic hepatitis B

790
Cancer-Associated Fibroblasts Promote Tumor Aggressiveness in Head and Neck Cancer through Chemokine Ligand 11 and CC Motif Chemokine Receptor 3 Signaling Circuit

WY Huang, YS Lin, YC Lin, S Nieh, YM Chang, TY Lee, SF Chen, KD Yang

Cancers (MDPI) Taiwan, 27 June 2022

Oncology

Key words: head and neck cancer, cancer-associated fibroblasts, CCL11, CCR3, tumor microenvironment

Pathological State: Cancer

Cell Line: FaDu cell lines (HTB-43 - ATCC)

791
Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure

R Zhang, S Chen, L Chen, L Ye, Y Jiang, H Peng, Z Guo, M Li, X Jiang, P Guo, D Yu, R Zhang, Y Niu, Y Zhuang, M Aschner, Y Zheng, D Li, W Chen

Particle and Fibre Toxicology (BMC) China, USA, 23 June 2022

Pulmonology

Key words: Particle matter, Chronic lung injuries, Single-cell RNA sequencing, IL-17A, Myeloid-derived suppressor cells

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

792
Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment

TY Wu, M Chen, IC Chen, YJ Chen, CY Chen, CH Wang, JJ Cheng, K Nepali, KH Chuang, JP Liou

Journal of Advanced Research (Elsevier) Taiwan, 22 June 2022

Oncology, Pharmacology

Key words: Cancer, Drug design, HDAC6/HSP90 dual inhibitor, Immunosensitizer, Tumor microenvironment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

793
PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis

J Luo, Q Lian, D Zhu, M Zhao, T Mei, B Shang, Z Yang, C Liu, W Xu, L Zhou, K Wu, X Liu, Y Lai, F Mao, W Li, C Zuo, K Zhang, M Lin, Y Zhou, Y Liu, L Lu, L Zhao

Genes & Diseases (Elsevier) China, 21 June 2022

Ophthalmology

Key words: Apoptosis, Glaucoma, Phagocytosis, PLSCR1, Retinal ganglion cells

Organism: Mouse

Tissue: Eye

Pathological State: Glaucoma

794
A diagnostic pitfall; small cell carcinoma-like features in basaloid squamous cell carcinoma of the esophagus

H Ishida, A Kasajima, T Yamauchi, R Akaishi, S Ueaki, Y Taniyama, F Fujishima, T Koike, T Kamei, AKY Lam, H Sasano

Histology and Histopathology (Griffith University) Japan, Australia, Germany, 21 June 2022

Oncology

Key words: esophagus, biopsy, basaloid squamous cell carcinoma, small cell carcinoma, diagnostic pitfall

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

795
Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer's Disease

SM Chen, TC Hsu, CH Chew, WT Huang, AL Chen, YF Lin, S Eddarkaoui, L Buee, CC Chen

International Journal of Molecular Sciences (MDPI) Taiwan, USA, France, 20 June 2022

Neuroscience, Pharmacology

Key words: neurodegenerative disease, Alzheimer's disease (AD), passive immunotherapy, encapsulated cell therapy, microtube array membrane (MTAMs)

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

796
Clinical value of urinary cytokines/chemokines as prognostic markers in patients with crescentic glomerulonephritis

J Jeon, J Park, HJ Boo, KE Yang, CJ Lee, JE Lee, K Kim, GY Kwon, W Huh, DJ Kim, HR Jang

Scientific reports (Nature) South Korea, 17 June 2022

Nephrology

Key words: Chemokines, Cytokines, Kidney diseases

Organism: Human

Tissue: Kidney

Pathological State: Crescentic Glomerulonephritis

797
Decreased CD11c‐positive dendritic cells in the tumor microenvironment predict double‐hit/triple‐hit genotype and survival in diffuse large B‐cell lymphoma

CT Yuan, SS Chuang, PY Cheng, K Chang, H Wang, JH Tsai, JY Liau, WC Chou

The Journal of Pathology: Clinical Research (Wiley) Taiwan, 17 June 2022

Oncology

Key words: high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, double-hit lymphoma, triple-hit lymphoma, diffuse large B-cell lymphoma, tumor microenvironment, dendritic cell, decision curve analysis

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

798
Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF‐κB pathway

Y Li, Q Zhuang, L Tao, K Zheng, S Chen, Y Yang, C Feng, Z Wang, H Shi, J Shi, Y Fang, L Xiao, D Geng, Z Wang

Cell Proliferation (Wiley) China, 16 June 2022

Osteology

Organism: Mouse

Tissue: Bone

Pathological State: Osteoporosis

799
Evaluation of Topical and Subconjunctival Injection of Hyaluronic Acid-Coated Nanoparticles for Drug Delivery to Posterior Eye

CH Tsai, LN Hoang, CC Lin, LC Pan, CL Wu, IC Lin, PY Wang, CL Tseng

Pharmaceutics (MDPI) Taiwan, China, 13 June 2022

Nanomedicine

Key words: posterior eye, hyaluronic acid, surface charges, nanoparticles, drug delivery, eyedrops, subconjunctival injection, retina

Organism: Mouse

Tissue: Eye

800
Occurrence of Lymphangiogenesis in Peripheral Nerve Autografts Contrasts Schwann Cell-Induced Apoptosis of Lymphatic Endothelial Cells In Vitro

C Hromada, J Hartmann, J Oesterreicher, A Stoiber, A Daerr, B Schädl, E Priglinger, AH Teuschl-Woller, W Holnthoner, J Heinzel, D Hercher

Biomolecules (MDPI) Austria, Germany, 12 June 2022

Neuroscience

Key words: peripheral nerve regeneration, lymphangiogenesis, Schwann cells, lymphatic endothelial cells

Cell Line: Fibrin hydrogels containing Schwann cell, lymphatic endothelial cells and adipose-derived stem cells

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