Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Filter publications

Customer Publications (A total of 3040 papers published)

601
Characterization of genetic humanized mice with transgenic HLA DP401 or DRA but deficient in endogenous murine MHC class II genes upon Staphylococcus aureus pneumonia

F Li, B Niu, L Liu, M Zhu, H Yang, B Qin, X Peng, L Chen, C Xu, X Zhou

Animal Models and Experimental Medicine (Wiley) China, 23 May 2023

Pathology

Organism: Mouse

Tissue: Lung, Lymphoid Tissue

Pathological State: Bacterial Infection

602
Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats

Y Huang, W Sun, F Gao, H Ma, T Yuan, Z Liu, H Liu, J Hu, J Bai, X Zhang, R Wang

Biology (MDPI) China, 23 May 2023

Neuroscience, Aging

Key words: aromatase, brain-derived estrogen, neurogenesis, gliogenesis, aging

Organism: Rat

Tissue: Brain

603
M2e‐specific antibodies protect against influenza PR8 virus in an isotype and route dependent manner

T Sun, Y Wang, P Zou, Q Wang, J Liu, W Liu, J Huang, F Wu

Journal of Medical Virology (Wiley) China, 23 May 2023

Immunology, Virology

Key words: Antibody, influenza A virus, isotype, M2e, protection

Organism: Mouse

Tissue: Lung

Pathological State: Influenza PR8 Infection

604
Identification of cervical cancer stem cells using single-cell transcriptomes of normal cervix, cervical premalignant lesions, and cervical cancer

T Zhang, L Zhuang, M Muaibati, D Wang, A Abasi, Q Tong, D Ma, L Jin, X Huang

eBioMedicine (Elsevier) China, 22 May 2023

Stem Cell Research, Oncology

Key words: Cervical cancer, Single-cell RNA sequencing, HSIL, Microinvasive carcinoma of the cervix, Cancer stem cell, Tumor microenvironment

Organism: Human

Tissue: Cervix

Pathological State: Cancer

605
The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage

X Zhu, W Liu, X Tang, Y Chen, X Ge, Q Ke, X Liang, Y Gan, Y Zheng, M Zou, M Deng, Y Liu, DWC Li, L Gong

Journal of Neuroinflammation (Springer) China, 22 May 2023

Ophthalmology

Key words: Retinal degeneration, BET, Neuroinflammation, PROTAC, cGAS-STING, Microglia/macrophage

Organism: Mouse

Tissue: Eye

606
Enhancing de novo ceramide synthesis induced by bisphenol A exposure aggravates metabolic derangement during obesity

G Wang, X Hong, J Yu, Y Zhang, Y Li, Z Li, Z Zhu, S Yuan, X Zhang, S Wang, F Zhu, Y Wang, C Wu, P Su, T Shen

Molecular Metabolism (Elsevier) China, UK, 22 May 2023

Endocrinology

Key words: Bisphenol A, ceramide, adipose tissue inflammation, insulin resistance, myriocin

Organism: Mouse

Tissue: Adipose Tissue

Pathological State: Obesity

607
APP/PS1 Gene-Environmental Cadmium Interaction Aggravates the Progression of Alzheimer's Disease in Mice via the Blood-Brain Barrier, Amyloid-β, and Inflammation

J Liu, Y Xie, Y Lu, Z Zhao, Z Zhuang, L Yang,, H Huang, H Li, Z Mao, S Pi, F Chen, Y He

Journal of Alzheimer's Disease (IOS Press) China, 20 May 2023

Neuroscience

Key words: Alzheimer’s disease, APP/PS1 gene, blood-brain barrier, cadmium, gene-environment interaction, inflammatory response

608
Increased number and domain of interlaminar astrocytes in layer I of the temporal cortex in epilepsy

N Zhou, Z Fan, Y Tong, X Xiao, Y Xie, Z Qi, L Chen

Neuropathology and Applied Neurobiology (Wiley) China, 20 May 2023

Neuroscience

Key words: Interlaminar astrocytes, Chaslin’s gliosis, Astrocyte domain, Temporal cortex, Epilepsy

Organism: Human

Tissue: Brain

Pathological State: Epilepsy

609
NLRP3‐Dependent Crosstalk between Pyroptotic Macrophage and Senescent Cell Orchestrates Trauma‐Induced Heterotopic Ossification During Aberrant Wound Healing

J Li, X Wang, Z Yao, F Yuan, H Liu, Z Sun, Z Yuan, G Luo, X Yao, H Cui, B Tu, Z Sun, C Fan

Advanced Science (Wiley) China, 19 May 2023

Osteology

Organism: Mouse

Tissue: Muscle, Bone

610
Targeting CD44 variant 5 with an antibody-drug conjugate is an effective therapeutic strategy for intrahepatic cholangiocarcinoma

Y Bei, J He, X Dong, Y Wang, S Wang, W Guo, C Cai, Z Xu, J Wei, B Liu, N Zhang, P Shen

Cancer Research (AACR) China, Ireland, 19 May 2023

Pharmacology, Oncology

Key words: intrahepatic cholangiocarcinoma, CD44 variant 5, antibody-drug conjugate, PDX

Organism: Human

Tissue: Bile duct

Pathological State: Cancer

611
Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression-and anxiety-like behavior in mice

R Wang, ZH Liu, N Bi, X Gu, C Huang, R Zhou, H Liu, HL Wang

Ecotoxicology and Environmental Safety (Elsevier) China, 19 May 2023

Neuroscience, Toxicology

Key words: Bisphenol A (BPA), Depression- and anxiety-like behavior, Microglial activation, Neuroinflammation, Medial prefrontal cortex (mPFC)

Organism: Mouse

Tissue: Brain

Pathological State: Depression

612
Cytolytic CD8+ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes

DR Collins, J Hitschfel, JM Urbach, GH Mylvaganam, NL Ly, U Arshad, ZJ Racenet, AG Yanez, TJ Diefenbach, BD Walker

Science Immunology (Science) USA, Germany, 19 May 2023

Immunology, Virology

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

613
Following nanoparticle uptake by cells using high-throughput microscopy and the deep-learning based cell identification algorithm Cellpose

B Yang, CJ Richards, TB Gandek, I de Boer, IA Zuazo, E Niemeijer, C Aberg

Frontiers in Nanotechnology (Frontiers Media S.A.) , 18 May 2023

Nanomedicine, Medical Image Analysis

Key words: nanoparticles, cell uptake, fluorescence microscopy, high-throughput, machine learning, image segmentation, modelling, Cellpose

Cell Line: HeLa cells

614
Peptide-Functionalized and Drug-Loaded Tomato Bushy Stunt Virus Nanoparticles Counteract Tumor Growth in a Mouse Model of Shh-Dependent Medulloblastoma

L Marchetti, F Novelli, B Tanno, S Leonardi, VM Hizam, C Arcangeli, L Santi, S Baschieri, C Lico, M Mancuso

International Journal of Molecular Sciences (MDPI) Italy, 17 May 2023

Pharmacology, Oncology

Key words: TBSV NPs, drug delivery system, doxorubicin, preclinical study, Ptch1+/− mice, MB therapy

Organism: Mouse

Tissue: Brain

615
Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma

Y Wang, X Xiang, H Chen, L Zhou, S Chen, G Zhang, X Liu, X Ren, J Liu, M Kuang, J Jiang, J She, Z Zhang, R Xue, H Jiang, J Wang, S Peng

Cell Reports Medicine (Cell Press) China, 16 May 2023

Immunology, Oncology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

616
Short‐term toll‐like receptor 9 inhibition leads to left ventricular wall thinning after myocardial infarction

M Lenz, A Kiss, P Haider, M Salzmann, M Brekalo, KA Krychtiuk, O Hamaza, K Huber, C Hengstenberg, BK Podesser, J Wojta, PJ Hohensinner, WS Speidl

ESC Heart Failure (Wiley) Austria, 16 May 2023

Pharmacology, Cardiology

Key words: CXCR2, Infarction, Ischaemia–reperfusion, Neutrophils, TLR9

Organism: Rat

Tissue: Heart

Pathological State: Ischaemia–reperfusion injury

617
Effects of Therapeutic Hypothermia on Macrophages in Mouse Cochlea Explants

W Bader, C Steinacher, HT Fischer, R Glueckert, J Schmutzhard, A Schrott-Fischer

International Journal of Molecular Sciences (MDPI) Austria, 16 May 2023

Otolaryngology

Key words: cochlea implant, IBA1, F4/80, CD163, CD45, immune response, inner ear, hypothermia

Organism: Mouse

Tissue: Ear

618
High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway

N Zhang, YQ Wang, C Sun, Y Shi, LG Hou, M Yao, M Hu, XM Wang, PP Ma, WJ Li, LL Jiang

American Journal of Cancer Research (e-Century Publishing) China, 15 May 2023

Oncology

Key words: Peroxisomal D-bifunctional protein, hepatocellular carcinoma, HepG2, apoptosis, energy metabolism, PI3K/AKT pathway

Organism: Human

Tissue: Liver

Pathological State: Cancer

619
Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-κB signaling pathway activation in aged mice

Y Yao, D Lin, Y Chen, L Liu, Y Wu, X Zheng

Inflammation Research (Springer) China, 15 May 2023

Aging

Key words: Microglia, Neuroinflammation, Postoperative cognitive dysfunction, Fluoxetine, Toll-like receptor 4

Organism: Mouse

Tissue: Brain

620
Characterization of Early and Late Damage in a Mouse Model of Pelvic Radiation Disease

R Vitali, F Palone, I De Stefano, C Fiorente, F Novelli, E Pasquali, E Fratini, M Tanori, S Leonardi, B Tanno, E Colantoni, S Soldi, S Galletti, M Grimaldi, AG Morganti, L Fuccio, S Pazzaglia, C Pioli, M Mancuso, L Vesci

International Journal of Molecular Sciences (MDPI) Italy, 15 May 2023

Radiotherapy

Key words: mouse model, intestinal damage, ionizing radiation, intestinal stem cells, fecal markers

Organism: Mouse

Tissue: Colon

Pathological State: Pelvic Radiation Disease

621
Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice

C Wang, B Zhao, J Zhai, A Wang, N Cao, T Liao, R Su, L He, Y Li, X Pei, Y Jia, W Yue

Cell Death & Disease (Nature) China, 12 May 2023

Stem Cell Research

Key words: Mesenchymal stem cells, Stem-cell research

Organism: Mouse

Tissue: Muscle

Pathological State: Sarcopenia

622
Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity

M Cui, Q He, Z Wang, Y Yu, H Gao, Z Liu, H Peng, H Wang, X Zhang, D Li, L Chen, X Xing, Y Xiao, W Chen, Q Wang

Environmental Pollution (Elsevier) China, 12 May 2023

Gastroenterology

Key words: Nanoplastics, Intestinal barrier, Tight junction protein, Mucin2, IL-10

Organism: Mouse

Tissue: Small Intestine

623
Inactivation of EGFR/ERK/NF‐κB signalling associates with radiosensitizing effect of 18β‐glycyrrhetinic acid on progression of hepatocellular carcinoma

YC Liu, CH Lin, KT Chen, DW Lai, FT Hsu

Journal of Cellular and Molecular Medicine (Wiley) Taiwan, 12 May 2023

Oncology

Key words: 18β- Glycyrrhetinic acid, epidermal growth factor receptor, ERK, hepatocellular carcinoma, NF-κB, radiotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

624
Inactivation of EGFR/ERK/NF-? B signalling associates with radiosensitizing effect of 18ß-glycyrrhetinic acid on progression of hepatocellular carcinoma

L Yu-Chang, CH Lin, KT Chen, DW Lai, FT Hsu

Journal of Cellular and Molecular Medicine (Wiley) Taiwan, 12 May 2023

Oncology

Key words: 18β- Glycyrrhetinic acid, epidermal growth factor receptor, ERK, hepatocellular carcinoma, NF- κB, radiotherapy

Organism: Mouse

Tissue: Spleen, Heart, Colon, Liver, Kidney

Pathological State: Cancer

625
Stromal and intratumoral T cell infiltration in head and neck squamous cell carcinoma

D Krum, S Rösch, G Dyckhoff, R Warta, PK Plinkert, C Herold-Mende

Laryngo-Rhino-Otologie (thieme-connect.com) Germany, 12 May 2023

Immunology, Oncology

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

626
Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study

TC Lin, YC Tsai, YA Chen, TH Young, CC Wu, YH Chiang, CH Kao, APH Huang, KY Chen, LK Tsai

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) Taiwan, 11 May 2023

Neuroscience

Key words: cerebrospinal fluid, intracerebral hemorrhage (ICH), neurogenesis, subventricular zone (SVZ), brain-derived neurotrophic factor (BDNF)

Organism: Rat

Tissue: Brain

Pathological State: Intracerebral hemorrhage

627
A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8+ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

A Rezapour, D Rydbeck, F Byvald, V Tasselius, G Danielsson, E Angenete, U Yrlid

OncoImmunology (Taylor & Francis) Sweden, 10 May 2023

Immunology, Oncology

Key words: Granzyme B, γδ T cells, Immunoscore, Type I Interferon, MxA, Neoadjuvant treatment, Rectal Cancer, Tumor infiltrating lymphocytes

Organism: Human

Tissue: Colon

Pathological State: Cancer

628
Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancer

AL Berr, K Wiese, G Dos Santos, CM Koch, KR Anekalla, M Kidd, JM Davis, Y Cheng, YS Hu, KM Ridge

Oncogene (Nature) USA, 09 May 2023

Oncology

Key words: Cell death, Intermediate filaments, Non-small-cell lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

629
Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

HK So, H Kim, J Lee, CL You, CE Yun, HJ Jeong, EJ Jin, Y Jo, D Ryu, GU Bae, JS Kang

Research (AAAS) South Korea, 09 May 2023

Neuroscience

Organism: Mouse

Tissue: Muscle

Pathological State: Age-related Motor Neuron Degeneration

630
Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain

CY Ding, YT Ding, H Ji, YY Wang, X Zhang, DM Yin

Cell & Bioscience (BMC) China, 05 May 2023

Neuroscience

Key words: Neuregulin 1, Cre-reporting mice, Olfactory bulb, Striatum, Cerebral cortex, Hippocampus, Hypothalamus, cerebellum, axon projection

Organism: Mouse

Tissue: Brain

631
Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC

M Li, L Duan, W Wu, W Li, L Zhao, A Li, X Lu, X He, Z Dong, K Liu, Y Jiang

Oncogenesis (Nature) China, 05 May 2023

Oncology

Key words: Cancer prevention, Oesophageal cancer, Target identification, Target validation

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

632
Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis

T Zhou, Y Xie, X Hou, W Bai, X Li, Z Liu, Q Man, J Sun, D Fu, J Yan, Z Zhang, Y Wang, H Wang, W Jiang, S Gao, T Zhao, A Chang, X Wang, H Sun, X Zhang, S Yang, C Huang, J Hao, J Liu

Journal of Experimental & Clinical Cancer Research (BMC) China, USA, 04 May 2023

Oncology

Key words: Pancreatic cancer, Organoids, High-throughput drug screening, c-Jun, Irbesartan

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

633
EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

L Chibaya, KC Murphy, KD DeMarco, S Gopalan, H Liu, CN Parikh, Y Lopez-Diaz, M Faulkner, J Li, JP Morris IV, YJ Ho, SK Chana, J Simon, W Luan, A Kulick, E de Stanchina, K Simin, LJ Zhu, TG Fazzio, SW Lowe, M Ruscetti

Nature Cancer (Nature) USA, 04 May 2023

Oncology

Key words: Cancer, Immunosurveillance, Pancreatic cancer, Senescence, Targeted therapies

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

634
Renewal of Oligodendrocyte Lineage Reverses Dysmyelination and CNS Neurodegeneration Through Corrected N-acetylaspartate Metabolism

A Lotun, D Li, H Xu, Q Su, S Tuncer, J Sanmiguel, M Mooney, CE Baer, R Ulbrich, SJ Eyles, L Strittmayer, LJ Hayward, DJ Gessler

Progress in Neurobiology (Elsevier) USA, China, Germany, 04 May 2023

Neuroscience

Key words: CNS, Neurodegeneration, Demyelination, Gene therapy, AAV, Canavan disease, N-acetylaspartate, Oligodendrocytes, Neurons

Organism: Mouse

Tissue: Brain

635
Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer

M Wang, CA Wisniewski, C Xiong, P Chhoy, HL Goel, A Kumar, LJ Zhu, R Li, PA St.Louis, LM Ferreira, H Pakula, Z Xu, M Loda, Z Jiang, MA Brehm, AM Mercurio

Science Translational Medicine (Science) USA, 03 May 2023

Immunology, Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

636
The ICAM-1 ligand HRV-A89 is internalized independently of clathrin-mediated endocytosis and its capsid reaches late endosomes

B Pfanzagl

Virology (Elsevier) Austria, 03 May 2023

Cell Biology

Key words: Arf6, Chlorpromazine, Endocytosis, ICAM-1, Imipramine, Rhinovirus

Cell Line: HeLa cells

637
Androgen therapy does not prevent bone loss and arterial calcifications in male rats with chronic kidney disease

K David, V Dubois, A Verhulst, V Sommers, V Sommers, D Schollaert, L Deboel, K Moermans, G Carmeliet, P D’Haese, D Vanderschueren, F Claessens, P Evenepoel, B Decallonne , D Schollaert , L Deboel , K Moermans , G Carmeliet , P D’Haese , D Vanderschueren V Sommers , D Schollaert , L Deboel , K Moermans , G Carmeliet , P D’Haese , D Vanderschueren , F Claessens , P Evenepoel , and B Decallonne

Journal of Endocrinology (Society for Endocrinology) Belgium, 02 May 2023

Endocrinology, Hepatology

Key words: androgen replacement therapy, chronic kidney disease, hypogonadism, bone loss, arterial calcification

Organism: Rat

Tissue: Blood Vessels

Pathological State: Kidney disease

638
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain

E Stroo, L Janssen, O Sin, W Hogewerf, M Koster, L Harkema, SA Youssef, N Beschorner, AHG Wolters, B Bakker, L Becker, Lilian Garrett, S Marschall, SM Hoelter, W Wurst, H Fuchs, V Gailus-Durner, M Hrabe de Angelis, A Thathiah, F Foijer, B van de Sluis, J van Deursen, M Jucker, A de Bruin, EAA Nollen

Life Science Alliance (Life Science Alliance) The Netherlands, Portugal, Germany, Belgium, USA, 02 May 2023

Neuroscience, Developmental Biology

Organism: Mouse

Tissue: Brain

639
Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses

MM Pillat, AC Ayupe, G Juvenal, C Meinerz, T Glaser, D Vieira da Silva Pellegrina, D Souza Paiva, CF Mello, B Monteiro Longo, E Moraes Reis, H Ulrich

Stem Cell Reviews and Reports (Springer) Brazil, 02 May 2023

Immunology, Neuroscience

Key words: Neural progenitor cells, Cytokines, Degenerative disease, Neural development, Neuroinflammation

Organism: Mouse

Cell Line: Neurospheres

640
Reshaping fish intestinal microbiota and facilitating barrier function by ZnO nanoparticles

S Ma, WX Wang

Environmental Science: Nano (Royal Society of Chemistry) China, 01 May 2023

Nanomedicine, Zoology

Organism: Fish

Tissue: Colon

641
Therapeutic efficacy of a MMAE-based anti-DR5 drug conjugate Oba01 in preclinical models of pancreatic cancer

C Zheng, D Zhou, W Li, Y Duan, M Xu, J Liu, J Cheng, Y Xiao, H Xiao, T Gan, J Liang, D Zheng, L Wang, S Zhang

Cell Death & Disease (Nature) China, 29 April 2023

Oncology, Pharmacology

Key words: Preclinical research, Targeted therapies

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

642
Expression-based subtypes define pathologic response to neoadjuvant immune-checkpoint inhibitors in muscle-invasive bladder cancer

AG Robertson, K Meghani, LF Cooley, KA McLaughlin, LA Fall, Z Yu, MA Castro, CS Groeneveld, A de Reyniès, VI Nazarov, VO Tsvetkov, B Choy, D Raggi, L Marandino, F Montorsi, T Powles, A Necchi, JJ Meeks

Nature Communications (Nature) Canada, USA, Brazil, France, USA, Italy, UK, 27 April 2023

Oncology

Key words: Bladder cancer, Tumour immunology

Organism: Human

Tissue: Bladder

Pathological State: Cancer

643
Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma

TY Hsieh, WW Sung, YC Chang, CY Yu, LY Lu, C Dong, TH Lee, SL Chen

Aging (Impact Journals) Taiwan, 21 April 2023

Pharmacology, Oncology

Key words: melatonin, bladder cancer, apoptosis, NF-κB, HIF-1α

Cell Line: UMUC3 and T24 cells

644
Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms

YT Magalhaes, VK Boell, GD Cardella, FL Forti

Cell Death & Disease (Nature) Brazil, 21 April 2023

Oncology

Key words: Cytoskeleton, DNA damage and repair

Organism: Human

Tissue: Brain

Pathological State: Cancer

645
BiTE‐Secreting CAR‐γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors

SW Huang, CM Pan, YC Lin, MC Chen, Y Chen, CI Jan, CC Wu, FY Lin, ST Wang, CY Lin, WH Huang, YT Chiang, WC Tsai, YH Chiu, TH Lin, SC Chiu, DY Cho

Advanced Science (Wiley) Taiwan, 20 April 2023

Oncology, Pharmacology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

646
Association of Neutrophil Extracellular Traps with Fistula Healing in Patients with Complex Perianal Fistulizing Crohn’s Disease

D Cao, K Qian, Y Zhao, J Hong, H Chen, X Wang, N Yang, C Zhang, J Cao, K Jia, G Wu, M Zhu, J Shen, Y Zhang, Z Cui, Z Wang

Journal of Crohn's and Colitis (Oxford Academic) China, 19 April 2023

Gastroenterology

Key words: Perianal fistulising Crohn’s disease; fistula healing; neutrophil extracellular traps.

Organism: Human

Tissue: Colon

Pathological State: Crohn's Dieseas

647
Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

O Leddy, FM White, BD Bryson

Elife (eLife Sciences Publications) USA, 19 April 2023

Immunology, Virology

Cell Line: Macrophages

648
BushenHuoxue decoction suppresses M1 macrophage polarization and prevents LPS induced inflammatory bone loss by activating AMPK pathway

S Chen, L Tao, F Zhu, Z Wang, Q Zhuang, Y Li, Y Yang, C Feng, H Shi, J Shi, L Zhu, L Xiao, D Geng, Z Wang

Heliyon (Cell Press) China, 19 April 2023

Immunology

Key words: Inflammatory bone loss, Bushen huoxue decoction, Inflammation, Macrophage polarization, Bone immune regulation

Organism: Mouse

Tissue: Bone

649
Targeting YAP1 ameliorates progesterone resistance in endometriosis

SC Lin, WN Li, SC Lin, HT Hou, YC Tsai, TC Lin, MH Wu, SJ Tsai

Human Reproduction (Oxford Academic) Taiwan, 18 April 2023

Reproductive Medicine

Key words: YAP1, miR-21-5p, PGR, progesterone resistance, endometriosis

Organism: Human

Tissue: Endometrium

Pathological State: Endometriosis

650
IKKα inhibition re-sensitizes acquired adriamycin-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis

J Liao, Q Qin, F Lv, Z Huang, B Lian, C Wei, Q Mo, QX Tan

Scientific Reports (Nature) China, 17 April 2023

Oncology, Pharmacology

Key words: Cancer, Chemical biology, Diseases, Genetics

Organism: Human

Tissue: Breast

Pathological State: Cancer

651
Adiponectin reverses β‐Cell damage and impaired insulin secretion induced by obesity

AC Munhoz, JDC Serna, EA Vilas‐Boas, CC Caldeira da Silva, TG Santos, FC Mosele, SL Felisbino, VR Martins, AJ Kowaltowski

Aging Cell (Wiley) Brazil, 14 April 2023

Endocrinology

Key words: adiponectin, calorie restriction, diabetes, obesity, oxidative phosphorylation

Organism: Mouse

Tissue: Pancreas

Pathological State: Obesity

652
Upregulation of dendrocyte-expressed seven transmembrane protein is associated with unfavorable outcomes in differentiated thyroid cancer

JJ Lee, YC Hsu, WC Huang, SP Cheng

Endocrine (Springer) Taiwan, 14 April 2023

Oncology, Pharmacology

Key words: DCSTAMP, Recurrence, Survival, Thyroid cancer, Immunohistochemistry

Organism: Human

Tissue: Thyroid

653
Single-cell transcriptome analysis revealed the immune profile of PD-1 blockade in gallbladder carcinoma liver metastasis

L Xie, Z Ning, Y Hua, P Wang, Z Meng

Hepatology Communications (Wiley) China, 14 April 2023

Oncology

Organism: Human

Tissue: Gallbladder

Pathological State: Cancer

654
Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity

VA Onofrei, E Anisie, CL Zamfir, A Ceasovschih, M Constantin, F Mitu, ED Grigorescu, AD Petroaie, DV Timofte

Journal of Clinical Medicine (MDPI) Romania, 14 April 2023

Endocrinology, Oncology

Key words: arterial stiffness, adipokines, morbid obesity, cardiovascular risk, perivascular adipose tissue

Organism: Human

Tissue: Adipose Tissue

Pathological State: Obesity

655
The effects of mild hypothermia on the electrode insertion trauma in a murine whole organ cochlea culture

J Schmutzhard, W Bader, T Gottfried, D Dejaco, R Glückert, J Dudas, A Schrott-Fischer

Frontiers in Neuroscience (Frontiers Media S.A.) Austria, 13 April 2023

Pathology

Key words: hypothermia, whole organ cochlea culture, electrode insertion trauma, cochlear implant, sensorineural hearing loss, hearing rehabilitation

Organism: Mouse

Tissue: Ear

656
Yellow mealworm (Tenebrio Molitor) enhances intestinal immunity in largemouth bass (Micropterus salmoides) via the NFκB/survivin signaling pathway

C Ge, X Liang, X Wu, J Wang, H Wang, Y Qin, M Xue

Fish & Shellfish Immunology (Elsevier) China, 11 April 2023

Zoology

Key words: Yellow mealworm, Largemouth bass, Intestinal immunity, NFκBp65, Survivin

Organism: Fish

Tissue: Colon

657
Axonal mapping of motor and sensory components within the ulnar nerve and its branches

V Tereshenko, U Maierhofer, LA Hruby, J Klepetko, DC Dotzauer, O Politikou, G Laengle, M Luft, C Festin, R Blumer, KD Bergmeister, OC Aszmann

Journal of Neurosurgery (American Association of Neurological Surgeons) Austria, 07 April 2023

Neuroscience

Key words: axon count, flexor carpi ulnaris muscle, flexor digitorum profundus muscle, nerve transfer, deep branch of the ulnar nerve, superficial branch of the ulnar nerve, peripheral nerve, anatomy

Organism: Human

Tissue: Nerves

658
Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia

Q Jiang, J Stachelscheid, J Bloehdorn, A Pacholewska, C Markus A, F Grotenhuijs, TA Müller, O Onder, P Wagle, CD Herling, M Kleppe, Z Wang, KR Coombes, S Robrecht, PS Dalvi, BA Lungu, P Mayer, LV Abruzzo, J Altmüller, BS Gathof, T Persigehl, K Fischer, BMC Jebaraj, H Young Rienhoff Jr, RC Ecker, Y Zhao, CJ Bruns, S Stilgenbauer, KSJ Elenitoba-Johnson, M Hallek, MR Schweiger, M Odenthal, E Vasyutina, M Herling

Blood (ASH Publications) Germany, USA, China, Romania, Austria, Australia, 06 April 2023

Oncology

Key words: chronic lymphocytic leukemia, TCL1A, KDM1A, epigenetics, histone modulation

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

659
Neuroprotective effects of resistance physical exercise on the APP/PS1 mouse model of Alzheimer's disease

HC Campos, DE Ribeiro, D Hashiguchi, DY Hukuda, C Gimenes, D Suchecki, RM Arida, H Ulrich, B Monteiro Longo

Frontiers in Neuroscience (Frontiers Media S.A.) Brazil, 06 April 2023

Pharmacology, Neuroscience

Key words: Alzheimer’s disease, resistance exercise, locomotor activity, corticosterone, amyloid-beta precursor protein

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s disease

660
Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis

N Das, LGN de Almeida, A Derakhshani, D Young, K Mehdinejadiani, P Salo, A Rezansoff, GD Jay, CP Sommerhoff, TA Schmidt, R Krawetz, A Dufour

Nature Communications (Nature) Canada, USA, Germany, 06 April 2023

Osteology

Key words: Biochemical networks, Proteases, Proteolysis, Rheumatology

Organism: Human

Tissue: Joint Tissue

Pathological State: Osteoarthritis

661
Prognostic values of tissue-resident CD8+ T cells in human hepatocellular carcinoma and intrahepatic cholangiocarcinoma

L Chen, H Huang, Z Huang, J Chen, Y Liu, Y Wu, A Li, J Ge, Z Fang, B Xu, X Zheng, C Wu

World Journal of Surgical Oncology (BMC) China, 06 April 2023

Oncology

Key words: Hepatocellular carcinoma, Intrahepatic Cholangiocarcinoma, Multicolor immunohistochemistry, Prognosis, Tissue-resident CD103+CD8+T cells

Organism: Human

Tissue: Liver

Pathological State: Cancer

662
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma

T Zhou, Q Man, X Li, Y Xie, X Hou, H Wang, J Yan, X Wei, W Bai, Z Liu, J Liu, J Hao

Cancer Biology & Medicine (China Anti-Cancer Association) China, 05 April 2023

Oncology, Machine Learning

Key words: Artificial intelligence, CD8, CSCs, tumor budding, PDAC, nomogram

Organism: Human

Tissue: Pancreas

663
Hypoxia switches TET1 from being tumor-suppressive to oncogenic

Q Yang, H Dang, J Liu, X Wang, J Wang, X Lan, M Ji, M Xing, P Hou

Oncogene (Nature) China, 05 April 2023

Oncology

Key words: Cancer microenvironment, Oncogenes

Organism: Mouse

Tissue: Thyroid

Pathological State: Cancer

664
Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses

Q Zeng, S Wang, M Li, S Wang, C Guo, X Ruan, R Watanabe, Y Lai, Y Huang, X Yin, C Zhang, B Chen, N Yang, H Zhang

Cell Metabolism (Cell Press) China, Japan, 04 April 2023

Immunology

Key words: CD36, acetylcholine, autoreactive B cell responses, choline acetyltransferase, fibroblastic reticular cells, lipid metabolism, mitochondrial respiration, spleen, systemic lupus erythematosus

Organism: Mouse

Tissue: Spleen

665
Molecules of senescent glial cells differentiate Alzheimer's disease from ageing

L Dai, F Gao, Q Wang, X Lv, Z Cheng, Y Wu, X Chai, H Zetterberg, K Blennow, AI Levey, J Shi, Y Shen

Journal of Neurology, Neurosurgery & Psychiatry (BMJ Journals) China, Sweden, UK, USA, 04 April 2023

Neuroscience

Organism: Human

Tissue: Brain

Pathological State: Alzheimer's disease

666
Red blood cell extracellular vesicles deliver therapeutic siRNAs to skeletal muscles for treatment of cancer cachexia

B Peng, Y Yang, Z Wu, R Tan, TT Pham, EYM Yeo, M Pirisinu, MK Jayasinghe, TC Pham, K Liang, N Shyh-Chang, MTN Le

Molecular Therapy (Cell Press) Singapore, China, 04 April 2023

Oncology

Key words: extracellular vesicles, cancer cachexia, siRNA, RNA delivery, myostatin, malonyl-CoA decarboxylase

Organism: Mouse

Tissue: Muscle

667
Characterization and Advancement of an Evaluation Method for the Treatment of Spontaneous Osteoarthritis in STR/ort Mice: GRGDS Peptides as a Potential Treatment for Osteoarthritis

MF Chen, CC Hu, YH Hsu, YT Chiu, KL Chen, SWN Ueng, Y Chang

Biomedicines (MDPI) Taiwan, 02 April 2023

Osteology

Key words: Osteoarthritis, STR/ort, cartilage, matrix metallopeptidase-13, SRY-box transcription factor 91

Organism: Mouse

Tissue: Joint Tissue

Pathological State: Osteoarthritis

668
A Deep-Learning-Computed Cancer Score for the Identification of Human Hepatocellular Carcinoma Area Based on a Six-Colour Multiplex Immunofluorescence Panel

A Dievernich, J Stegmaier, P Achenbach, S Warkentin, T Braunschweig, UP Neumann, U Klinge

Cells (MDPI) Germany, The Netherlands, 02 April 2023

Osteology, Machine Learning

Key words: hepatocellular carcinoma, HCC, convolutional neural network, CNN, U-net, multiplex, fluorescence, immunofluorescence, microscopy, cancer score

Organism: Human

Tissue: Liver

Pathological State: Cancer

669
Analysis of Single- and Double-Stranded DNA Damage in Osteoblastic Cells after Hyperbaric Oxygen Exposure

N Schönrock, F Tillmans, S Sebens, W Kähler, S Klapa, B Rieger, H Scherthan, A Koch

Antioxidants (MDPI) Germany, USA, 01 April 2023

Pharmacology

Key words: oxidative stress; DNA damage; osteoblasts; gamma-H2AX; hyperbaric hyperoxia; comet assay; DSBs

Organism: Human

Pathological State: Oxidative Stress

Cell Line: SAOS-2

670
Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue

N Chen, M Yuan, NN Zhang, M Chen, R Liu, J Wang, P Lu

iScience (Cell Press) China, 01 April 2023

Cell Biology

Key words: β-catenin, UCP1, thermogenesis, beige adipocytes, energy expenditure

Organism: Mouse

Tissue: Adipose Tissue

671
DARPP‐32 cells and neuropil define striosomal system and isolated matrix cells in human striatum

CJ Arasaratnam, JJ Song, T Yoshida, MA Curtis, AM Graybiel, RLM Faull, HJ Waldvogel

Journal of Comparative Neurology (Wiley) New Zealand, USA, 31 March 2023

Neuroscience

Key words: DARPP-32, spinyprojectionneurons, striatum, striosomes

Organism: Human

Tissue: Brain

672
High bacillary burden and the ESX-1 type VII secretion system promote MHC class I presentation by Mycobacterium tuberculosis infected macrophages to CD8 T-cells

D Mott, J Yang, C Baer, K Papavinasasundaram, CM Sassetti, SM Behar

The Journal of Immunology (AHA Journals) USA, 31 March 2023

Immunology, Microbiology

673
Optimizing culturing conditions in patient derived 3D primary slice cultures of head and neck cancer

M do Carmo Greier, A Runge, J Dudas, L Carpentari, VH Schartinger, A Randhawa, M Mayr, M Petersson, H Riechelmann

Frontiers in Oncology (Frontiers Media S.A.) Austria, 30 March 2023

Biological Methods, Oncology

Key words: head and neck cancer, tumor microenvironment, cultured neoplastic cells, platelet rich fibrin, culture media

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

674
Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy

T Dong, ZQ Zhang, LH Sun, W Zhang, Z Zhu, L Lin, Lin Yang, A Lv, C Liu, Q Li, RF Yang, X Zhang, Y Niu, HZ Chen, DP Liu, WM Tong

Brain Pathology (Wiley) China, 28 March 2023

Neuroscience

Key words: antioxidant, Mic60, mitochondria, mitochondrial encephalomyopathies, neurodegeneration, reactive oxygen species

Organism: Mouse

Tissue: Brain

675
CD226 identifies functional CD8+ T cells in the tumor microenvironment and predicts a better outcome for human gastric cancer

H Huang, Z Huang, J Ge, J Yang, J Chen, B Xu, S Wu, X Zheng, L Chen, X Zhang, J Jiang

Frontiers in Immunology (Frontiers Media S.A.) China, 28 March 2023

Oncology, Gastroenterology

Key words: CD226, CD8+ T cells, multi-color immunohistochemical staining, prognosis, gastric cancer

Organism: Human

Tissue: Stomach

Pathological State: Cancer

676
Protective effects of resveratrol on the ethanol‐induced disruption of retinogenesis in pluripotent stem cell‐derived organoids

H Li, L Gao, Z Ye, J Du, W Li, L Liang, Q Zeng, J Xi, W Yue, Z Li

FEBS Open Bio (Wiley) China, 27 March 2023

Ophthalmology

Key words: ethanol, fetal alcohol syndrome, PI3K-AKT signalling, resveratrol, retinal organoids

Cell Line: Human embryonic stem cells

677
Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages

X Li, X Chen, S Gong, J Zhao, C Yao, H Zhu, R Xiao, Y Qin, R Li, N Sun, X Li, F Dong, T Zhao, Y Pan, J Yang

Theranostics (Ivyspring International Publisher) China, 27 March 2023

Immunology, Oncology

Key words: Platelets, TAMs, CRC, PSGL-1/JNK/STAT1, C5a/C5aR1

Organism: Human

Tissue: Colon

Pathological State: Cancer

678
Functional Peptide-Loaded Gelatin Nanoparticles as Eyedrops for Cornea Neovascularization Treatment

YC Chu, HW Fang, YY Wu, YJ Tang, EH Hsieh, Y She, CY Chang, IC Lin, YJ Chen, GS Liu, CL Tseng

International Journal of Nanomedicine (Taylor & Francis) Taiwan, Australia, 23 March 2023

Nanomedicine, Ophthalmology

Key words: gp91 peptide, gelatin, nanoparticles, ocular retention, control release, corneal neovascularization, eye drops

Organism: Mouse

Tissue: Eye

Pathological State: Corneal neovascularization

679
Occurrence, risk assessment, and in vitro and in vivo toxicity of antibiotics in surface water in China

C Zhang, Y Chen, S Chen, X Guan, Y Zhong, Q Yang

Ecotoxicology and Environmental Safety (Elsevier) China, 22 March 2023

Toxicology, Ecology

Key words: Antibiotics, Environmental pollution, Surface water, Intestinal flora, Oxidative stress

Organism: Mouse

Tissue: Liver

680
Dual-Ratiometric Magnetic Resonance Tunable Nanoprobe with Acidic-microenvironment-responsive Property to Enhance the Visualization of Early Tumor Pathological Changes

R Cao, N Tang, Y Zhu, A Chen, Y Li, R Ge, Y Li, Z Huang, J Guo, J Deng, H Lu, Z Lu, H Forgham, TP Davis, R Qiao, Z Wang

Nano Research (Sciopen) China, USA, Australia, 22 March 2023

Nanomedicine, Oncology

Key words: ratiometric nanoprobe, dually activatable, microenvironment visualization, early diagnosis, pathological changes

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

681
Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization

D Chen, N Hu, S Xing, L Yang, F Zhang, S Guo, S Liu, X Ma, X Liang, H Ma

Journal of Ovarian Research (BMC) China, 21 March 2023

Reproductive Medicine

Key words: Placental mesenchymal stem cells, Premature ovarian insufficiency, Macrophage, Inflammasome, NLRP3, Interferon-γ, Pyroptosis

Organism: Rat

Tissue: Ovaries

682
Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy

GS Dunlap, D DiToro, J Henderson, SI Shah, M Manos, M Severgnini, A Weins, I Guleria, PA Ott, N Murakami, DA Rao

Nature Communications (Nature) USA, 21 March 2023

Immunology, Transplantation Medicine

Key words: Graft-versus-host disease, Immunotherapy, Kidney, Transplant immunology, Tumour immunology

Organism: Human

Tissue: Skin, Lymphoid Tissue, Kidney

Pathological State: Graft-versus-host disease

683
Analysis of the mechanism underlying diabetic wound healing acceleration by Calycosin-7-glycoside using network pharmacology and molecular docking

J Chen, H Ma, Y Meng, Q Liu, Y Wang, Y Lin, D Yang, W Yao, Y Wang, X He, P Li

Phytomedicine (Elsevier) China, 20 March 2023

Pharmacology

Key words: Diabetic wound healing, Calycosin-7-glucoside, Mitochondrial metabolism, Macrophage polarization, Network pharmacology, Molecular docking

Organism: Mouse

Tissue: Skin

Pathological State: Imnflammation

684
Intrinsic RIG-I restrains STAT5 activation to modulate anti-tumor activity of CD8+ T cells

X Jiang, J Lin, C Shangguan, X Wang, B Xiang, J Chen, H Guo, W Zhang, J Zhang, Y Shi, J Zhu, H Yang

The Journal of Clinical Investigation (American Society for Journal of Clinical Investigation) China, 16 March 2023

Immunology, Oncology

Key words: RIG-I, Tumor-infiltrating CD8+ , T cell, STAT5 activation, Colon cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

685
Thorium (IV) Triggers Ferroptosis through Disrupting Iron Homeostasis and Heme Metabolism in the Liver Following Oral Ingestion

M Ma, R Wang, M Xu

Journal of Hazardous Materials (Elsevier) China, 15 March 2023

Hepatology

Key words: Thorium, Hepatotoxicity, Ferroptosis, Iron homeostasis, Heme metabolism

Organism: Mouse

Tissue: Liver

686
Fast and sensitive GCaMP calcium indicators for imaging neural populations

Y Zhang, M Rózsa, Y Liang, D Bushey, Z Wei, J Zheng, D Reep, GJ Broussard, A Tsang, G Tsegaye, S Narayan, CJ Obara, JX Lim, R Patel, R Zhang, MB Ahrens, GC Turner, SSH Wang, WL Korff, ER Schreiter, K Svoboda, JP Hasseman, I Kolb, LL Looger

Nature (Nature) USA, 15 March 2023

Neuroscience

Key words: Fluorescent proteins, Neural circuits

Organism: Mouse

Tissue: Brain

687
Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer

Z Valko, Z Megyesfalvi, A Schwendenwein, C Lang, S Paku, N Barany, B Ferencz, A Horvath-Rozsas, I Kovacs, E Schlegl, V Pozonec, K Boettiger, M Rezeli, G Marko-Varga, F Renyi-Vamos, M Alireza Hoda, T Klikovits, K Hoetzenecker, Michael Grusch, V Laszlo, B Dome, K Schelch

British Journal of Cancer (Nature) Austria, Hungary, Sweden, 14 March 2023

Oncology

Key words: Small-cell lung cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

688
Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma

J Chen, K Liu, Y Luo, M Kang, J Wang, G Chen, J Qi, W Wu, B Wang, Y Han, L Shi, K Wang, X Han, X Ma, W Liu, Y Ding, L Wang, H Liang, L Wang, J Chen

Gastroenterology (Elsevier) China, USA, 14 March 2023

Oncology

Key words: Gastric Cancer, T-Cell State, CXCL13, Immune Checkpoint Blockade

Organism: Human

Tissue: Stomach

Pathological State: Cancer

689
Expression of Checkpoint Molecules in the Tumor Microenvironment of Intrahepatic Cholangiocarcinoma: Implications for Immune Checkpoint Blockade Therapy

L Heij, J Bednarsch, X Tan, M Rosin, S Appinger, K Reichel, D Pecina, M Doukas, RM Van Dam, J Garcia Vallejo, F ulmer, S Lang, T Luedde, FG Rocha, S Sivakumar, UP Neumann

Cells (MDPI) Germany, The Netherlands, USA, UK, 09 March 2023

Oncology, Immunology

Key words: cholangiocarcinoma, tumor microenvironment, checkpoint molecules, multiplexed imaging, immunotherapy

Organism: Human

Tissue: Bile duct, Liver

Pathological State: Cancer

690
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

VN Hariharan, M Shin, CW Chang, D O'Reilly, A Biscans, K Yamada, Z Guo, M Somasundaran, Q Tang, K Monopoli, PM Krishnamurthy, G Devi, N McHugh, DA Cooper, D Echeverria, J Cruz, IL Chan, P Liu, SY Lim, J McConnell, S Prakash Singh, S Hildebrand, J Sousa, SM Davis, Z Kennedy, C Ferguson, BMD Godinho, Y Thillier, J Caiazzi, S Ly, M Muhuri, K Kelly, F Humphries, A Cousineau, KM Parsi, Q Li, Y Wang, R Maehr, G Gao, D Korkin, WM McDougall, RW Finberg, KA Fitzgerald, JP Wang, JK Watts, A Khvorova

PNAS (Proceedings of the National Academy of Sciences of the United States of America) USA, 09 March 2023

SARS-CoV-2, Immunology

Key words: SARS-COV-2, antisense oligos, small interfering RNAs, mouse model, lung

Organism: Mouse

Tissue: Lung

Pathological State: Covid-19

691
Effects of paraprobiotics on bile acid metabolism and liver health in largemouth bass (Micropterus salmoides) fed a cottonseed protein concentrate-based diet

X Xie, X Liang, H Wang, Q Zhu, J Wang, Y Chang, E Leclercq, M Xue, J Wang

Animal Nutrition (Elsevier) China, France, 07 March 2023

Zoology

Key words: Cottonseed protein concentrate, Multi-yeast strain fractions, Micropterus salmoides, Liver health, Bile acid metabolism, Gut microbiota

Organism: Bass Fish

Tissue: Liver, Small Intestine

692
In Situ Formation of Injectable Gelatin Methacryloyl (GelMA) Hydrogels for Effective Intraocular Delivery of Triamcinolone Acetonide

C Shen, X Zhao, Z Ren, B Yang, X Wang, A Hu, J Hu

International Journal of Molecular Sciences (MDPI) China, 04 March 2023

Pharmacology

Key words: gelatin methacryloyl, triamcinolone acetonide, retina hydrogel system, hydrogel drug release, intraocular drug delivery, injectable gel

Organism: Rabbit

Tissue: Eye

693
The protective effect of cannabinoids against colorectal cancer cachexia through modulation of inflammation and immune responses

SK Ng, DJ Chung, LC Chang, CK Luo, SH Jwo, YH Lee, JS Lin, CH Wang, TT Wei

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 03 March 2023

Immunology, Oncology

Key words: Colorectal cancer cachexia, Cytokines, Cannabinoids, CD8+ T cell, Cannabinoid receptor 2

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

694
Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration

LW Lin, SW Wang, WC Huang, TK Huynh, CY Lai, CY Ko, YC Fong, JJ Lee, SF Yang, CH Tang

Cells (MDPI) Taiwan, 03 March 2023

Aging

Key words: melatonin, endothelial progenitor cells, vascular endothelial growth factor (VEGF), platelet-derived growth factor-BB (PDGF-BB), angiogenesis, neovascular age-related macular degeneration

Cell Line: Endothelial progenitor cells

695
miR-194 upregulates CYP7A1 expression via β-catenin signaling and aggravates cholestatic liver diseases

PC Chen, CP Hsu, SY Wang, TY Wu, YJ Lin, YT Chen, SH Hsu

The American Journal of Pathology (Elsevier) Taiwan, 02 March 2023

Hepatology

Organism: Mouse

Tissue: Liver

696
Androgen therapy does not prevent bone loss and arterial calcifications in male rats with CKD

K David, V Dubois, A Verhulst, V Sommers, D Schollaert, L Deboel, K Moermans, G Carmeliet, P D'Haese, D Vanderschueren, F Claessens, P Evenepoel, B Decallonne

Journal of Endocrinology (Society for Endocrinology) Belgium, 01 March 2023

Endocrinology

Key words: androgen replacement therapy, chronic kidney disease, hypogonadism, bone loss, arterial calcification

Organism: Rat

Tissue: Blood Vessels

Pathological State: Kidney disease

697
Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells

MQ Yan, Y Wang, Z Wang, XH Liu, YM Yang, XY Duan, H Sun, XM Liu

Journal of the Endocrine Society (Oxford Academic) China, 28 February 2023

Oncology

Key words: mitochondrial fusion, testosterone, granulosa cells, steroidogenic acute regulatory protein, sex hormones, polycystic ovary syndrome

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

698
Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo

P Strasser, B Montsch, S Weiss, H Sami, C Kugler, S Hager, H Schueffl, R Mader, O Brüggemann, CR Kowol, M Ogris, P Heffeter, I Teasdale

Small (Wiley) Austria, 26 February 2023

Nanomedicine

Key words: biodistribution, bottlebrush polymers, nanomedicine, pharmacokinetics, polyglutamate, polymer therapeutics, polyphosphazenes

Organism: Mouse

Tissue: Bone, Kidney, Xenograft Tumor

Pathological State: Cancer

699
Electrical Sympathetic Neuromodulation Protects Bone Marrow Niche and Drives Hematopoietic Regeneration during Chemotherapy

YT Hsu, LH Chen, YH Liu, SK Chu, TY Chen, KJ Tsai, MR Shen, W Liu

Small Methods (Wiley) Taiwan, USA, 26 February 2023

Neuroscience

Key words: bone marrow niche, chemotherapy-induced nerve damage, electrical neuromodulation, hematopoiesis

Organism: Rat

Tissue: Bone

700
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke

H Zheng, X Guo, S Kang, Z Li, T Tian, J Li, F Wang, P Yu, S Chang, YZ Chang

Cell Death & Disease (Nature) China, 25 February 2023

Neuroscience

Key words: Stroke

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

701
UHRF1/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer

S Lin, H Xu, L Qin, M Pang, Z Wang, M Gu, L Zhang, C Zhao, X Hao, Z Zhang, W Ding, J Ren, J Huang

Acta Pharmaceutica Sinica B (Elsevier) China, 24 February 2023

Oncology

Key words: Lung cancer, Intratumor heterogeneity, Splice variants, Intragenic CpG methylation, Protease serine 3, Myeloid zinc finger 1, UHRF1/DNMT1, 5-Aza-CdR

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

702
Immune Microenvironment in Sporadic Early-Onset versus Average-Onset Colorectal Cancer

F Andric, A Al-Fairouzi, Y Wettergren, L Szeponik, E Bexe-Lindskog, JC Cusack Jr, G Tumusiime, M Quiding-Järbrink, D Ljungman

Cancers (MDPI) Sweden, USA, Uganda, 24 February 2023

Oncology

Key words: early-onset colorectal cancer, tumor microenvironment, tumor-infiltrating lymphocytes, gene expression, immunofluorescence

Organism: Human

Tissue: Colon

Pathological State: Cancer

703
Transgenic HPV11-E2 protein modulates URR activity in vivo

S Wang, V Gramm, E Laport, T Holland-Letz, A Alonso, J Schenkel

Transgenic Research (Springer) Germany, 24 February 2023

Virology

Key words: HPV-E2, Human papillomavirus type 11, Reporter gene, Transgenic mouse model, Upstream regulatory region URR

Organism: Mouse

Tissue: Skin

704
Poly (I: C) Exacerbates Airway Goblet Cell Hyperplasia and Lung Inflammation in HDM-Exposed Balb/C Mice by YAP/FOXM1 Pathway

ML Bu, MH Li, M Feng, JR Wang, L Sun

International Archives of Allergy and Immunology (Karger) China, 23 February 2023

Immunology

Key words: YAP, Poly(I:C), Asthma, Airway inflammation, Goblet cell hyperplasia

705
Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging

VA Onofrei, CL Zamfir, E Anisie, A Ceasovschih, M Constantin, F Mitu, CA Adam, ED Grigorescu, AD Petroaie, D Timofte

Medicina (MDPI) Romania, 22 February 2023

Cardiology

Key words: arterial stiffness, cardiovascular risk, morbid obesity, pulse wave analysis, adiponectin, chemerin, adipocyte

Organism: Human

Tissue: Adipose Tissue

Pathological State: Obesity

706
Oolong tea of different years protects high-fat diet-fed mice against obesity by regulating lipid metabolism and modulating gut microbiota

WW Fang, KF Wang, F Zhou, J Ou-yang, ZY Zhang, CW Liu, HZ Zeng, JA Huang, ZH Liu

Food & Function (Royal Society of Chemistry) China, 21 February 2023

Endocrinology

707
SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway

W Zhang, X Li, M Jiang, C Ji, G Chen, Q Zhang, P Liu, R Zhang, X Ren, W Yu, J Yu

Journal of Leukocyte Biology (Oxford Academic) China, 20 February 2023

Oncology

Key words: breast cancer, early-stage myeloid-derived suppressor cells, Wnt/mTOR pathway, autophagy

Organism: Human

Tissue: Breast

Pathological State: Cancer

708
Intestinal Farnesoid X Receptor Modulates Duodenal Surface Area but Does Not Control Glucose Absorption in Mice

J Yang, TH van Dijk, M Koehorst, R Havinga, JF de Boer, F Kuipers

International Journal of Molecular Sciences (MDPI) The Netherlands, 18 February 2023

Gastroenterology

Key words: glucose absorption, intestinal FXR, duodenum, GS3972

Organism: Mouse

Tissue: Small Intestine

709
MRI histogram analysis of tumor-infiltrating CD8+ T cell levels in patients with glioblastoma

C Xue, Q Zhou, P Zhang, B Zhang, Q Sun, S Li, J Deng, X Liu, J Zhou

NeuroImage: Clinical (Elsevier) China, 18 February 2023

Oncology

Key words: Glioblastoma, Magnetic resonance imaging, Histogram analysis, CD8+ T cells, Tumor microenvironment

Organism: Human

Tissue: Brain

Pathological State: Cancer

710
Bavachinin Protects the Liver in NAFLD by Promoting Regeneration via Targeting PCNA

X Dong, S Lu, Y Tian, H Ma, Y Wang, X Zhang, G Sun, Y Luo, X Sun

Journal of Advanced Research (Elsevier) China, 16 February 2023

Hepatology

Key words: Bavachinin, CC-ABPP, NAFLD, Liver regeneration, PCNA

Organism: Hamster

Tissue: Liver

711
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease

S Yan, X Zheng, Y Lin, C Li, Z Liu, J Li, Z Tu, Y Zhao, C Huang, Y Chen, J Li, X Song, B Han, W Wang, W Liang, L Lai, XJ Li, S Li

Nature Biomedical Engineering (Nature) China, 16 February 2023

Neuroscience

Key words: Huntington's disease, Preclinical research

Organism: Pig

Tissue: Brain

Pathological State: Huntington's Disease

712
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer

M Zagorulya, L Yim, DM Morgan, A Edwards, E Torres-Mejia, N Momin, CV McCreery, IL Zamora, BL Horton, JG Fox, KD Wittrup, JC Love, S Spranger

Immunity (Cell Press) USA, 14 February 2023

Immunology, Oncology

Key words: regulatory T cells, cross-presenting dendritic cells, cytotoxic T cells, T cell dysfunction, T cell priming, anti-tumor immunity, non-small cell lung cancer, interferon-gamma, Th1-like effector regulatory T cells, tissue-specific immunity

Tissue: Lymphoid Tissue

Pathological State: Cancer

713
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation

T Krausgruber, A Redl, D Barreca, K Doberer, D Romanovskaia, L Dobnikar, M Guarini, L Unterluggauer, L Kleissl, D Atzmuller, C Mayerhofer, A Kopf, S Saluzzo, CX Lim, P Rexie, T Weichhart, C Bock, G Stary

Immunity (Cell Press) Austria, 14 February 2023

Immunology

Organism: Human

Tissue: Skin

Pathological State: Lesional Sarcoidosis

714
Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-specific Pathways

Y Li, P Liu, Y Zhou, H Maekawa, JB Silva, MJ Ansari, K Boubes, Y Alia, DK Deb, BR Thomson, J Jin, SE Quaggin

Journal of The American Society of Nephrology (Wolters Kluwer) USA, 14 February 2023

Nephrology

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Ischemia

715
CD39-Expressing CD8+ T Cells as a New Molecular Marker for Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma

M Liu, Y Zhao, Z Xiao, R Zhou, X Chen, S Cui, S Cao, X Huang, T Chen, X Huo, G Zhang, Z Tian, N Wang

Cancers (MDPI) China, 13 February 2023

Oncology

Key words: esophageal squamous cell carcinoma, CD39+CD8+ T cells, diagnosis, prognosis, nomogram, tumor microenvironment

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

716
Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis

T Qiao, W Yang, X He, P Song, X Chen, R Liu, J Xiao, X Yang, M Li, Y Gao, G Chen, Y Lu, J Zhang, J Leng, H Ren

Cell Death & Disease (Nature) China, 13 February 2023

Oncology

Key words: Cancer microenvironment, Kupffer cells, Metastasis, Tumour angiogenesis

Organism: Mouse

Tissue: Liver, Allograft Tumor

Pathological State: Cancer

717
Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1

X Liu, Y Jiang, H Zhou, X Zhao, M Li, Z Bao, Z Wang, C Zhang, Z Xie, J Zhao, Z Dong, K Liu, Z Guo

Cell Death & Disease (Nature) China, 13 February 2023

Oncology

Key words: Cancer prevention, Proteomics, Target identification

Organism: Mouse

Tissue: Xenograft Tumor, Skin

Pathological State: Cancer

718
Prevalence of tumour-infiltrating CD103+ cells identifies therapeutic-sensitive prostate cancer with poor clinical outcome

Q Zhou, Y Ou, X Dai, X Chen, S Wu, W Chen, M Hu, C Yang, L Zhang, H Jiang

British Journal of Cancer (Nature) China, 09 February 2023

Oncology

Key words: Cancer microenvironment, Immune evasion, Prognostic markers

Organism: Human

Tissue: Prostate

Pathological State: Cancer

719
Tissue‐resident CXCR4+ macrophage as a poor prognosis signature promotes pancreatic ductal adenocarcinoma progression

Z Liao, L Ye, T Li, X Jin, X Lin, Q Fei, H Zhang, S Shi, X Yu, K Jin, W Wu

International Journal of Cancer (Wiley) China, 09 February 2023

Oncology

Key words: CXCR4, pancreatic ductal adenocarcinoma, prognosis, SPARC, tissue-resident macrophage

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

720
Skin infiltrate composition as a telling measure of responses to checkpoint inhibitors.

C Kosche, D Jaishankar, C Cosgrove, P Ramesh, S Hong, L Li, RS Shivde, D Bhuva, BE Perez White, SS Munir, H Zhang, KQ Lu, JN Choi, IC Le Poole

JID Innovations (Elsevier) USA, 09 February 2023

Oncology

Organism: Human

Tissue: Skin

721
Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet‐Induced Adiposity

Y Sun, J Zhang, J Hong, Z Zhang, P Lu, A Gao, M Ni, Z Zhang, H Yang, J Shen, J Liu, W Xue, Q Lv, Y Bi, YA Zeng, W Gu, G Ning, W Wang, R Liu, J Wang

Advanced Science (Wiley) China, 08 February 2023

Endocrinology

Key words: obesity, pathogenic gene, RSPO1, thermogenesis, whole-exome sequenc-ing, Wnt signaling

Organism: Mouse

Tissue: Adipose Tissue

722
Artificial Base-Directed In Vivo Assembly of an Albumin–siRNA Complex for Tumor-Targeting Delivery

Y Sun, D Yu, X Geng, D Ding, Y Yang, Z Liu, Z Xiao, R Wang, W Tan

ACS Applied Materials & Interfaces (ACS Publications) China, 07 February 2023

Oncology, Pharmacology

Key words: artificial base, siRNA, albumin, targeted delivery, long circulation, tumor accumulation

Organism: Mouse

Tissue: Heart, Kidney, Liver, Spleen, Lung

723
Artificial Base-Directed In Vivo Assembly of an Albumin–siRNA Complex for Tumor-Targeting Delivery

Y Sun, D Yu, X Geng, D Ding, Y Yang, Z Liu, Z Xiao, R Wang, W Tan

ACS Applied Materials & Interfaces (ACS Publications) China, 07 February 2023

Pharmacology, Oncology

724
Empagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis

CC Chung, YK Lin, YC Chen, YH Kao, YH Yeh, NN Trang, YJ Chen

Cardiovascular Diabetology (Springer) Taiwan, Vietnam, 06 February 2023

Cardiology

Key words: Fibroblasts, Fibrosis, Empagliflozin, Sodium-glucose co-transporter 2, Calcium, Sodium-Hydrogen exchanger

Organism: Rat

Tissue: Heart

Pathological State: Atrial fibrosis

725
Synthesis and Anti-Melanoma Activity of L-Cysteine-Coated Iron Oxide Nanoparticles Loaded with Doxorubicin

LI Toderascu, LE Sima, S Orobeti, PE Florian, M Icriverzi, VA Maraloiu, C Comanescu, N Iacob, V Kuncser, I Antohe, G Popescu-Pelin, G Stanciu, P Ionita, CN Mihailescu, G Socol

Nanomaterials (MDPI) Romania, 04 February 2023

Nanomedicine

Key words: magnetic nanoparticles, melanoma, L-Cys, Dox, chemotherapeutic

Cell Line: B16F10 melanoma murine cell line, CCD1070SK fibroblast and melanoma A375 human cell lines

726
The Role of Green Tea Catechin Epigallocatechin Gallate (EGCG) and Mammalian Target of Rapamycin (mTOR) Inhibitor PP242 (Torkinib) in the Treatment of Spinal Cord Injury

L Machova Urdzikova, V Cimermanova, K Karova, J Dominguez, K Stepankova, M Petrovicova, K Havelikova, CD Ghandi, M Jhanwar-Uniyal, P Jendelova

Antioxidants (MDPI) Czech Republic, USA, 03 February 2023

Neuroscience

Key words: spinal cord injury, mTOR pathway, EGCG, PP 242, inflammatory response, neuroregeneration, astrogliosis, axonal growth

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

727
Amentoflavone induces caspase‐dependent/− independent apoptosis and dysregulates cyclin‐dependent kinase‐mediated cell cycle in colorectal cancer in vitro and in vivo

CH Lin, KH Lin, HJ Ku, KC Lee, SS Lin, FT Hsu

Environmental Toxicology (Wiley) Taiwan, 02 February 2023

Oncology

Organism: Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

728
PKCδ promotes the invasion and migration of colorectal cancer through c-myc/NDRG1 pathway

H Jia, Y Shao, X Zhou, G Yang, L Huang, B Aikemu, SC Li, CS Ding, XD Fan, HJ Hong, S Zhang, RJ Pan, J Sun

Frontiers in Oncology (Frontiers Media S.A.) China, 02 February 2023

Oncology

Key words: colorectal cancer, protein kinase C δ, N-myc downstream-regulated gene 1, metastasis, epithelial-mesenchymal transition

Organism: Human

Tissue: Colon

Pathological State: Cancer

729
Mapping thalamic innervation to individual L2/3 pyramidal neurons and modeling their 'readout'of visual input

A Balcioglu, R Gillani, M Doron, K Burnell, T Ku, A Erisir, K Chung, I Segev, E Nedivi

Nature Neuroscience (Nature) USA, South Korea, Israel, 02 February 2023

Neuroscience

Key words: Sensory processing, Striate cortex

Organism: Mouse

Tissue: Brain

730
Apolipoprotein E negatively regulates allergic airway inflammation and remodeling in mice with OVA-induced chronic asthma

Y Shen, L Li, W Chen, Q Li, Y Xu, F He, C Wang, Z Tian, Y Chen, Y Yang

International Immunology (Elsevier) China, 01 February 2023

Allergy Research

Key words: ApoE, Airway remodeling, Chronic airway inflammation, Th2 responses

Organism: Mouse

Tissue: Lung

Pathological State: Asthma

731
Overexpression of Both Human Sodium Iodide Symporter (NIS) and BRG1-Bromodomain Synergistically Enhances Radioiodine Sensitivity by Stabilizing p53 through NPM1 Expression

J Na, CH Lee, JK Chung, H Youn

International Journal of Molecular Sciences (MDPI) South Korea, 01 February 2023

Oncology

Key words: sodium iodide symporter, radioiodine therapy, iodine-131, brahma-related gene 1 bromodomain, radiosensitization, thyroid cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

732
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models

M Datta, S Chatterjee, EM Perez, S Gritsch, S Roberge, M Duquette, IX Chen, K Naxerova, A S Kumar, M Ghosh, KE Emblem, MR Ng, WW Ho, P Kumar, S Krishnan, X Dong, MC Speranza, MR Neagu, JB Iorgulescu, RY Huang, G Youssef, DA Reardon, AH Sharpe, GJ Freeman, ML Suvà, L Xu, RK Jain

PNAS (Proceedings of the National Academy of Sciences of the United States of America) USA, Poland, Norway, 01 February 2023

Immunology, Oncology

Key words: immune checkpoint blockers, glioblastoma, immune-related adverse events, tumor microenvironment , biomarkers

Organism: Mouse

Tissue: Brain, Xenograft Tumor

Pathological State: Cancer

733
Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression

C Liu, M Zhang, X Yan, Y Ni, Y Gong, C Wang, X Zhang, L Wan, H Yang, C Ge, Y Li, W Zou, R Huang, X Li, B Sun, B Liu, J Yue, J Yu

Science Advances (Science) China, 27 January 2023

Oncology

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

734
Development and Characterization of a Highly Selective Turn-On Fluorescent Ligand for β3-Adrenergic Receptor

W Li, Z Ma, L Du, M Li

Analytical Chemistry (ACS Publications) China, 26 January 2023

Biological Methods

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

735
Lingguizhugan decoction improves non-alcoholic steatohepatitis partially by modulating gut microbiota and correlated metabolites

M Zhu, X Wang, K Wang, Z Zhao, Y Dang, G Ji, F Li, W Zhou

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) China, 26 January 2023

Hepatology

Key words: Lingguizhugan decoction, NASH, MCD diet, gut microbiota, metabolomics

Organism: Rat

Tissue: Liver

Pathological State: Non-alcoholic steatohepatitis

736
New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma

IV Militaru, AA Rus, CVA Munteanu, G Manica, SM Petrescu

Frontiers in Oncology (Frontiers Media S.A.) Romania, 26 January 2023

Oncology

Key words: melanoma biomarkers, amelanotic melanoma, mass spectrometry, proteomics, melanoma diagnostic, melanoma prognostic

Pathological State: Cancer

Cell Line: A375, SKMEL28, SKMEL23 and MNT1 cells

737
Transcriptional Regulation of Math1 by Aryl Hydrocarbon Receptor: Effect on Math1+ Progenitor Cells in Mouse Small Intestine

Y Yagishita, T Joshi, TW Kensler, N Wakabayashi

Molecular and Cellular Biology (Taylor & Francis) USA, 26 January 2023

Gastroenterology

Key words: AhR, Math1, intestinal organoids, Math1+ progenitor cells, goblet cells

738
PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon

X Yang, T Yabe-Wada, J Han, F Saito, C Ogasawara, S Yamada, N Onai

International Immunology (Oxford Academic) Japan, China, 25 January 2023

Immunology

Key words: PCBP1, macrophage, CCL2, IBD, proinflammatory cytokine

739
Intravenous aav9 administration results in safe and widespread distribution of transgene in the brain of mini-pig

Y Lin, C Li, W Wang, J Li, C Huang, X Zheng, Z Liu, X Song, Y Chen, J Gao, J Wu, J Wu, Z Tu, L Lai, XJ Li, S Li, S Yan

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 24 January 2023

Neuroscience

Key words: AAV9, CNS, large animal, pig, neurodegeneration

Organism: Pig

Tissue: Brain

740
LRRC3B and its promoter hypomethylation status predicts response to anti-PD-1 based immunotherapy

L Luo, S Fu, W Du, L He, X Zhang, Y Wang, y Zhou, S Hong

Frontiers in Immunology (Frontiers Media S.A.) China, 24 January 2023

Oncology, Immunology

Key words: pan-cancer, tumor immune microenvironment, immunotherapy, leucine rich repeat containing 3B, DNA methylation

Organism: Human

Tissue: Lung

Pathological State: Cancer

741
Glycoside combinations of Buyang Huanwu decoction ameliorate atherosclerosis via STAT3, HIF-1, and VEGF

F Yan, H Ding, Z Sun, J Liu, J Li, D Zhou, W Zhang

Naunyn-Schmiedeberg's Archives of Pharmacology (Springer) China, 24 January 2023

Cardiology, Pharmacology

Key words: Network pharmacology, Buyang Huanwu decoction, Glycoside combination, Atherosclerosis, Angiogenesis

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

742
Melatonin improves muscle injury and differentiation by increasing Pax7 expression

CM Su, CH Tsai, HT Chen, YS Wu, JW Chang, SF Yang, CH Tang

International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan, 22 January 2023

Pharmacology

Key words: melatonin, Pax7, muscle injury, differentiation, miR-3475-3p

Organism: Mouse

Tissue: Muscle

Pathological State: Muscle injury

743
Modulatory Effects of Heat-Inactivated Streptococcus Thermophilus Strain 7 on the Inflammatory Response: A Study on an Animal Model with TLR3-Induced Intestinal Injury

GA Lee, YW Chang, WL Lin, YCSH Yang, WJ Chen, FH Huang, YR Liu

Microorganisms (MDPI) Taiwan, Malaysia, 20 January 2023

Microbiology, Immunology

Key words: Streptococcus thermophilus, microbiota, poly I:C, inflammation, IL-15

Organism: Mouse

Tissue: Small Intestine

Pathological State: TLR3-Induced Intestinal Injury

744
Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?

D Schmidbauer, S Fink, F Rousset, H Löwenheim, P Senn, R Glueckert

International Journal of Molecular Sciences (MDPI) Austria, Germany, Switzerland, 19 January 2023

Neuroscience

Key words: nerve regeneration, cochlear implant, spiral ganglion, neurotrophin treatment, electrical stimulation

Cell Line: Murine spiral ganglion neurons

745
Engineering orthotopic tumor spheroids with organ-specific vasculatures for local chemoembolization evaluation

Y Gao, J Xiao, Z Chen, Y Ma, X Liu, D Yang, H Liang Leo, H Yu, J Kong, Q Guo

Biomaterials Science (Royal Society of Chemistry) China, Singapore, 17 January 2023

Biological Methods

746
Prognostic role of the innate immune signature CD163 and “eat me” signal calreticulin in clear cell renal cell carcinoma

T Anno, N Tanaka, K Takamatsu, K Hakozaki, R Kufukihara, Y Baba, T Takeda, K Matsumoto, S Morita, T Kosaka, S Mikami, H Nishihara, R Mizuno, M Oya

Cancer Immunology, Immunotherpay (Springer) Japan, 17 January 2023

Oncology

Key words: Renal cell carcinoma, Kidney cancer, Innate immunity, CD163, Tumor-associated macrophage, Calreticulin, Eat me signal, Survival

Organism: Human

Tissue: Kidney

Pathological State: Cancer

747
Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington's disease

A Matsushima, SS Pineda, JR Crittenden, H Lee, K Galani, J Mantero, G Tombaugh, M Kellis, M Heiman, AM Graybiel

Nature Communications (Nature) USA, 17 January 2023

Neuroscience

Key words: Huntington's disease, Molecular neuroscience, Transcriptomics

Organism: Mouse

Tissue: Brain

Pathological State: Huntington's disease

748
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

D Savic, TB Steinbichler, J Ingruber, G Negro, B Aschenbrenner, H Riechelmann, U Ganswindt, S Skvortsov, J Dudas, II Skvortsova

Cells (MDPI) Austria, 16 January 2023

Oncology

Key words: HNSCC, erastin, xCT, ERK signaling

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

749
Environmental endocrine disruptor Bisphenol A induces metabolic derailment and obesity via upregulating IL-17A in adipocytes

X Hong, Y Zhou, Z Zhu, Y Li, Z Li, Y Zhang, XX Hu, F Zhu, Y Wang, M Fang, Y Huang, T Shen

Environment International (Elsevier) China, 16 January 2023

Endocrinology

Key words: Obesity, Bisphenol A, Inflammation, Insulin resistance, IL-17A

Organism: Mouse

Tissue: Adipose Tissue

Pathological State: Obesity

750
Daurisoline suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting MEK1/2 kinase

D Wang, W Zhang, X Zhang, M Li, Q Wu, X Li, L Zhao, Q Yuan, Y Yu, J Lu, J Zhao, Z Dong, K Liu, Y Jiang

Molecular Carcinogenesis (Wiley) China, 16 January 2023

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

751
BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti‐PD‐1/PD‐L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity

Z Cai, J Chen, Z Yu, H Li, Z Liu, D Deng, J Liu, C Chen, C Zhang, Z Ou, M Chen, J Hu, X Zu

Advanced Science (Wiley) China, 15 January 2023

Oncology, Pharmacology

Organism: Human

Tissue: Bladder

Pathological State: Cancer

752
miR-432 exerts a protective effect against myocardial ischemia/reperfusion injury by activating the β-catenin/HIF-1α pathway and augmenting NRF2-mediated anti-oxidative stress

RY Su, WY Tai, HS Yin, XY Geng

American Journal of Translational Research (e-Century Publishing Corporation) China, 15 January 2023

Cardiology

Key words: apoptosis, microRNA, myocardial ischemia/reperfusion injury, oxidative stress

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Ischemia

753
Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia–reperfusion injury

T Mei, J Wu, K Wu, M Zhao, J Luo, X Liu, B Shang, W Xu, Z Yang, Y Lai, C Liu, H Gong, X Gao, Y Zhuo, M Lin, L Zhao

Annals of Translational Medicine (AME Publishing Company) China, 15 January 2023

Ophthalmology

Key words: Lipocalin-2 (LCN2), retinal ischemia-reperfusion injury (RIR injury), ferroptosis, retinal ganglion cell (RGC), visual impairment

Organism: Mouse

Tissue: Eye

Pathological State: Retinal Ischemia

754
SN‐38, an active metabolite of irinotecan, enhances anti‐PD1 treatment efficacy in head and neck squamous cell carcinoma

YM Lee, YH Chen, DL Ou, CL Hsu, JH Liu, JY Ko, MCT Hu, CT Tan

The Journal of Pathology (Wiley) Taiwan, USA, 15 January 2023

Oncology

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

755
Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice

Q Ma, D Su, J Huo, G Yin, D Dong, K Duan, H Cheng, H Xu, J Ma, D Liu, B Mou, J Peng, L Cheng

Neuroscience Bulletin (Springer) China, 13 January 2023

Neuroscience

Key words: Microglia, Mechanical allodynia, Laterality, Spinal dorsal horn, Aβ, Dynamic allodynia, Punctate allodynia

Organism: Mouse

Tissue: Brain, Spinal Cord

Pathological State: Mechanical Allodynia

756
Production and characterization of cell-penetrating recombinant botulinum neurotoxin type A

X Wei, J Hu, L Jiang, L Li, J Liu

STAR Protocols (Elsevier) China, 13 January 2023

Biological Methods

Key words: Cell culture, Protein Biochemistry, Protein Expression and Purification, Biotechnology and Bioengineering

Cell Line: N2a cells

757
The imbalance of NKG2A and NKG2D expression is involved in NK cell immunosuppression and tumor progression of HBV‐HCC patients

L Yu, L Sun, X Liu, X Wang, H Yan, Q Pu, Y Xie, Y Jiang, J Du, Z Yang

Hepatology Research (Wiley) China, 11 January 2023

Oncology

Key words: NK cell, NKG2A, NKG2D, hepatitis B virus-related hepatocellular carcinoma, immunosuppression

Organism: Human

Tissue: Liver

Pathological State: Cancer

758
Theabrownin inhibits obesity and non-alcoholic fatty liver disease in mice via serotonin-related signaling pathways and gut-liver axis

HY Li, SY Huang, DD Zhou, RG Xiong, M Luo, A Saimaiti, MK Han, RY Gan, HL Zhu, HB Li

Journal of Advanced Research (Elsevier) China, 11 January 2023

Hepatology

Key words: non-alcoholic fatty liver disease, anti-obesity, theabrownin, serotonin, gut microbiota

Organism: Mouse

Tissue: Liver

759
Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

D Liu, C Liang, B Huang, X Zhuang, W Cui, L Yang, Y Yang, Y Zhang, X Fu, X Zhang, L Du, W Gu, X Wang, C Yin, R Chai, B Chu

Advanced Science (Wiley) China, USA, 10 January 2023

Oncology

Key words: 3-HA, 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), 5-HT, ferroptosis, kynureninase (KYNU, monoamine oxidase A (MAOA), tryptophan

Organism: Human

Tissue: Liver, Kidney

Pathological State: Cancer

760
Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy

R Chi, C Chai, G Liu, H Cao, B Yang

Human Cell (Springer) China, 10 January 2023

Cardiology

Key words: OSAS, CIH, Autophagy, BNIP3, Apoptosis, Cardiac hypertrophy

Organism: Rat

Tissue: Heart

Pathological State: Contractile dysfunction

761
Immune dysregulation in immunoglobulin G4–related disease

T Maehara, R Koga, S Nakamura

Japanese Dental Science Review (Elsevier) Japan, 09 January 2023

Immunology

Key words: Autoimmune, Anti-inflammatory, Single-cell RNA sequencing, IgG4-related disease, Cytotoxic T cells, Salivary gland

762
Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive 18F-FDG PET/CT and Serum 1H-NMR Analysis: An Orthotopic Murine Model Study

YH Chung, TH Hung, CF Yu, CK Tsai, CC Weng, F Jhang, FH Chen, G Lin

Metabolites (MDPI) Taiwan, 09 January 2023

Oncology

Key words: lung cancer, 18F-FDG, 1H-NMR, animal study, metastasis

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

763
Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance

F Du, G Yin, L Han, X Liu, D Dong, K Duan, J Huo, Y Sun, L Cheng

Neuroscience Bulletin (Springer) China, 09 January 2023

Neuroscience

Key words: μ-opioid receptor, Morphine, Mechanical allodynia, Punctate allodynia, Dynamic allodynia, OIH, Tolerance, Aβ-fiber

Organism: Mouse

Tissue: Brain, Spinal Cord

Pathological State: Mechanical Allodynia

764
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity

Z Fu, S Chen, Y Zhu, D Zhang, P Xie, Q Jiao, J Chi, S Xu, Y Xue, X Lu, X Song, M Christofanilli, WJ Gradishar, K Kalinsky, Y Yin, B Zhang, Y Wan

Science Advances (Science) USA, China, 06 January 2023

Oncology

Organism: Human

Tissue: Breast

Pathological State: Cancer

765
Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts

YC Huang, MF Hou, YM Tsai, YC Pan, PH Tsai, YS Lin, CY Chang, EM Tsai, YL Hsu

Cellular Oncology (Springer) Taiwan, 06 January 2023

Oncology

Key words: Acetyl-CoA carboxylase α, Breast cancer, Metabolism reprogramming, Pre-metastatic niche, Senescence

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

766
Role of iodine density value on dual-energy CT for detection of high tumor cell proportion region in lung cancer during CT-guided transthoracic biopsy

Y Ma, S Li, G Huang, X Huang, Q Zhou, W Wang, J Wang, F Zhao, Z Li, X Chen, B Zhu, J Zhou

European Journal of Radiology (Elsevier) China, 06 January 2023

Oncology, Radiotherapy

Key words: Dual-layer spectral detector computed tomography, Iodine density, Transthoracic lung biopsy, High tumor cell proportion region

Organism: Human

Tissue: Lung

Pathological State: Cancer

767
Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis

BY Ahn, Y Jeong, S Kim, Y Zhang, SW Kim, YE Leem, JS Kang

Experimental & Molecular Medicine (Nature) South Korea, 06 January 2023

Cell Biology

Key words: Calcification, Stress signalling

Organism: Mouse

Tissue: Blood Vessels

768
PLVAP as an Early Marker of Glomerular Endothelial Damage in Mice with Diabetic Kidney Disease

EE Wolf, A Steglich, F Kessel, H Kröger, J Sradnick, S Reichelt-Wurm, K Eidenschink, MC Banas, E Wolf, R Wanke, F Gembardt, VT Todorov

International Journal of Molecular Sciences (MDPI) Germany, 06 January 2023

Nephrology

Key words: diabetic kidney disease, endothelial damage, PLVAP, diabetic models, glomerular hypertrophy

Organism: Mouse

Tissue: Kidney

Pathological State: Diabetic Kidney Disease

769
The transcription factor Eomes promotes expression of inhibitory receptors on hepatic CD8+ T cells during HBV persistence

L Yu, Y Guan, L Li, N Lu, C Zhang

The FEBS Journal (Wiley) China, 05 January 2023

Virology, Immunology

Key words: CD8+ T cell exhaustion, chronic HBV persistence, Eomes, inhibitory receptor, transcription factor

Organism: Mouse

Tissue: Liver

Pathological State: Hepatitis B virus Infection

770
Comparing the Therapeutic Mechanism and Immune Response of Human and Mouse Mesenchymal Stem Cells in Immunocompetent Mice With Acute Liver Failure

CH Wang, CY Chen, KH Wang, AP Kao, YJ Chen, PH Lin, M Chen, TY Wu, JJ Cheng, KD Lee, KH Chuang

Stem Cells Translational Medicine (Oxford Academic) Taiwan, 04 January 2023

Immunology, Hepatology

Key words: mesenchymal stem cells, immunomodulatory, IL-6, F4/80, liver regeneration, liver fibrosis

Organism: Mouse

Tissue: Liver

Pathological State: Acute Liver Failure

771
Limonin counteracts obesity by activating thermogenesis in brown and white adipose tissues

M Yan, S Jin, Z Wang, T Xia, Y Liu, Q Chang

Journal of Functional Foods (Elsevier) China, 02 January 2023

Endocrinology

Key words: Limonin, Obesity, Brown adipose tissue, White adipose tissues, Thermogenesis

Organism: Mouse

Tissue: Liver

772
Nesfatin-1 stimulates CCL2-dependent monocyte migration and M1 macrophage polarization: implications for rheumatoid arthritis therapy

JW Chang, SC Liu, YY Lin, XY He, YS Wu, CM Su, CH Tsai, HT Chen, YC Fong, SL Hu, CC Huang, CH Tang

International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan, 01 January 2023

Rheumatology

Key words: rheumatoid arthritis, nesfatin-1, CCL2, M1 macrophages, synovial fibroblasts

Organism: Human, Mouse

Tissue: Joint Tissue

Pathological State: Rheumatoid Arthritis

773
Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma

JL Sieow, HL Penny, SY Gun, LQ Tan, K Duan, JPS Yeong, A Pang, D Lim, HC Toh, TKH Lim, E Engleman, O Rotzschke, LG Ng, J Chen, SM Tan, SC Wong

International Journal of Molecular Sciences (MDPI) Singapore, USA, 01 January 2023

Oncology

Key words: neutrophils, pancreatic cancer, hypoxia-inducible factor 1-alpha

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

774
The TgF344-AD Rat: Behavioral and Proteomic Changes Associated with Aging and Protein Expression in a Transgenic Rat Model of Alzheimer's Disease

B Bac, C Hicheri, C Weiss, A Buell, N Vilcek, C Spaeni, C Geula, JN Savas, JF Disterhoft

Neurobiology of Aging (Elsevier) USA, 30 December 2022

Neuroscience

Key words: watermaze, 6E10, pTau, neuroinflammation, TREM2, Learning Index, proteomics

Organism: Rat

Tissue: Brain

Pathological State: Alzheimer's Disease

775
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Y Zhou, X He, Y Jiang, Z Wang, Y Yu, W Wu, C Zhang, J Li, Y Huo, X Chen, Z Liu, J Zhao, K Liu, Z Dong

Frontiers of Medicine (Springer) China, 29 December 2022

Oncology

Key words: benzydamine, cyclin-dependent kinase 2, patient-derived xenograft, esophageal squamous cell carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

776
The effect of isovitexin on lipopolysaccharide-induced renal injury and inflammation by induction of protective autophagy

CY Tseng, PR Yu, CC Hsu, HH Lin, JH Chen

Food and Chemical Toxicology (Elsevier) Taiwan, 23 December 2022

Nephrology

Key words: Kidney injury, Isovitexin, Lipopolysaccharide, Inflammation, Autophagy

Organism: Mouse

Tissue: Kidney

Pathological State: Lipopolysaccharide-induced kidney injury

777
Myofibroblast stroma differentiation in infiltrative basal cell carcinoma is accompanied by regulatory T‐cells

JM Ressler, N Zila, A Korosec, J Yu, R Silmbrod, V Bachmayr, J Tittes, J Strobl, BM Lichtenberger, C Hoeller, P Petzelbauer

Journal of Cutaneous Pathology (Wiley) Austria, 23 December 2022

Oncology

Key words: Basal cell carcinoma, infiltrative BCC, regulatory T-cells, TGF-β, alpha smooth muscle actin

Organism: Human

Tissue: Skin

Pathological State: Cancer

778
Mitigation of Cellular and Bacterial Adhesion on Laser Modified Poly (2-Methacryloyloxyethyl Phosphorylcholine)/Polydimethylsiloxane Surface

S Nistorescu, M Icriverzi, P Florian, A Bonciu, V Marascu, N Dumitrescu, G Gradisteanu Pircalabioru, L Rusen, A Mocanu, A Roseanu, A Cimpean, F Grama 6, V Dinca, DA Cristian

Nanomaterials (MDPI) Romania, 23 December 2022

Tissue Engineering

Key words: MAPLE, zwitterionic coating, cellular response

Cell Line: Fibroblasts cultured on PDMS scaffolds

779
Biomimetic Prussian blue nanozymes with enhanced bone marrow-targeting for treatment of radiation-induced hematopoietic injury

B Zhang, G Chen, X Wu, Y Li, Y Xiao, J Li, L He, Y Li, S Wang, J Zhao, C Liu, H Zhou, Y Li, X Pei

Biomaterials (Elsevier) China, 21 December 2022

Nanomedicine

Key words: Prussian blue nanozymes, Mesenchymal stem cell membrane, Reactive oxygen species, Radiation-induced hematopoietic injury, Targeting therapy

Organism: Mouse

Tissue: Bone

Pathological State: Radiation-induced hematopoietic injury

780
Avicularin Alleviates Osteoporosis in Ovariectomized Mice by Inhibiting Osteoclastogenesis through NF-κB Pathway Inhibition

Q Zhuang, S Chen, W Zhang, M Gu, L Xiao, Y Li, Y Yang, C Feng, H Li, D Geng, Z Wang

Journal of Agricultural and Food Chemistry (ACS Publications) China, 20 December 2022

Osteology

Key words: osteoclast avicularin bone loss NF-κB

Organism: Mouse

Tissue: Bone

781
R158Q and G212S, novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome

Z Li, H Wu, S Wei, M Liu, Y Shi, M Li, N Wang, L Fang, B Xiang, L Gao, C XU, J Zhao

Frontiers of Medicine (Frontiers Media S.A.) China, 19 December 2022

Endocrinology

Key words: Gitelman syndrome, mouse model, compound heterozygous, hypokalemia, Slc12a3

Organism: Mouse

Tissue: Kidney

Pathological State: Gitelman syndrome

782
A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging

H Zhang, Y Guo, J Jiao, Y Qiu, Y Miao, Y He, Z Li, C Xa, L Li, J Cai, K Xu, X Liu, C Zhang, BH Bay, S Song, Y Yang, M Peng, Y Wang, H Fan

Nature Biomedical Engineering (Nature) China, 19 December 2022

Biological Methods

Key words: Biomedical engineering, Magnetic resonance imaging

Organism: Pig

Tissue: Liver

783
Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

PA Goldsteen, AM Sabogal Guaqueta, PPM Mulder, IST Bos, M Eggens, L Van der Koog, JT Soeiro, AJ Halayko, K Mathwig, LEM Kistemaker, EMJ Verpoorte, AM Dolga, R Gosens

Frontiers in Pharmacology (Frontiers Media S.A.) The Netherlands, 18 December 2022

Neuroscience

Key words: asthma, cholinergic, neuron, organ-on-chip, stem cell

Cell Line: Airway cholinergic neurons

784
Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice

STJ Ang, EM Crombie, H Dong, KT Tan, A Hernando, D Yu, S Adamson, S Kim, DJ Withers, H Huang, SY Tsai

Nature Communications (Nature) Singapore, USA, UK, 17 December 2022

Aging

Key words: Ageing, Muscle stem cells, Skeletal muscle

Organism: Mouse

Tissue: Muscle

785
Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10

J Yang, C Hou, H Wang, EA Perez, HC Do-Umehara, H Dong, V Arunagiri, F Tong, M Van Scoyk, M Cho, X Liu, X Ge, RA Winn, KM Ridge, X Wang, NS Chandel, J Liu

Cancer Letters (Elsevier) USA, 17 December 2022

Oncology

Key words: KRAS, Non-small cell lung cancer, Pcdh10, Gene regulation, Miz1

Organism: Mouse

Tissue: Lung

786
FOXM1 increases hTERT protein stability and indicates poor prognosis in gastric cancer

Q Tang, C Liu, S Zhang, L He, Y Liu, J Wang, X Zhao, X Li

Neoplasia (Elsevier) China, 16 December 2022

Oncology

Key words: Gastric cancer, FOXM1, hTERT, ubiquitination, Wnt/β-catenin

Organism: Human

Tissue: Stomach

Pathological State: Cancer

787
Distribution and Toxicity of Submicron Plastic Particles in Mice

TY Tsou, SH Lee, TH Kuo, CC Chien, HC Chen, TJ Cheng

Environmental Toxicology and Pharmacology (Elsevier) Taiwan, 15 December 2022

Toxicology

Key words: Submicron microplastics, Oral gavage, Number concentration, Flow cytometry, Oxidative stress, Inflammation

Organism: Mouse

Tissue: Lung

788
Synergistic cytotoxicity of perifosine and ABT‐737 to colon cancer cells

B Adamová, K Říhová, J Pokludová, P Beneš, J Šmarda, J Navrátilová

Journal of Cellular and Molecular Medicine (Wiley) Czech Republic, 15 December 2022

Oncology

Tissue: Spheroid

Cell Line: HT-29 and HCT-116 human adenocarcinoma cells

789
Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions

M Salzmann, H Platzer, M Mussbacher, M Derler, M Lenz, P Haider, M Brekalo, JB Kral-Pointner, S Kastl, WS Speidl, KT Preissner, U Schubert, M Bischoff, J Wojta, PJ Hohensinner

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Austria, Germany, 10 December 2022

Immunology, Microbiology

Key words: Atherosclerosis, ICAM-1, Extracellular adherence protein, Neutrophils, NET

Organism: Mouse

Tissue: Heart

Pathological State: Staphylococcus aureus Infection

790
Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells

J Chen, J Liu, Z Chen, D Feng, C Zhu, J Fan, S Zhang, X Zhang, J Xu

Virologica Sinica (Elsevier) China, 10 December 2022

Virology

Key words: Myosin IIA (MYH9), Influenza A virus (IAV), vRNP activity, Virus-host interactions, Virus entry

Cell Line: MDCK cells

791
A Proof-of-Concept Preclinical Study Using a Novel Thermal Insulation Device in a Porcine Kidney Auto-Transplantation Model

L Ernst, Z Czigany, P Paschenda, M Schulz, L Breuer, J Kunczik, M Czapli, W Liu, D Jiang, U Klinge, S Djudjaj, P Boor, G Lurje, E Kobayashi, RH Tolba

International Journal of Molecular Sciences (MDPI) Germany, Japan, 09 December 2022

Transplantation Medicine

Key words: kidney transplantation, organ insulation, ischemic reperfusion injury

Organism: Pig

Tissue: Kidney

792
The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer's disease mouse model

CF de Veij Mestdagh, F Koopmans, JC Breiter, JA Timmerman, PC Vogelaar, G Krenning, HD Mansvelder, AB Smit, RH Henning, RE van Kesteren

Alzheimer's Research & Therapy (Springer) The Netherlands, 09 December 2022

Neuroscience

Key words: Alzheimer's disease, APP/PS1 mice, Hibernation-derived compound, SUL-138, Chromanols, Long-term potentiation, Hippocampus-dependent contextual fear memory, Amyloid-beta plaques, Mass-spectrometry, Mitochondria, Fatty acid metabolism

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

793
Angiotensin-converting enzyme 2 in human plasma and lung tissue

J Xie, QF Huang, Z Zhang, Y Dong, H Xu, Y Cao, X Wang, JG Wang

Blood Pressure (Taylor & Francis) China, 09 December 2022

Cardiology

Key words: ACE2, plasma, lung, tissue, hypertension

794
Fumarate hydratase inhibits non‑small cell lung cancer metastasis via inactivation of AMPK and upregulation of DAB2

A Vadhan, YF Yang, YM Wang, PY Chen, SC Tzou, KH Cheng, SCS Hu, TL Cheng, YY Wang, SSF Yuan

Oncology Letters (Spandidos Publications) Taiwan, 09 December 2022

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

795
Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer

K Imamura, Y Tomita, R Sato, T Ikeda, S Iyama, T Jodai, M Takahashi, A Takaki, K Akaike, S Hamada, S Sakata, K Saruwatari, S Saeki, K Ikeda, M Suzuki, T Sakagami

International Journal of Molecular Sciences (MDPI) Japan, USA, 08 December 2022

Oncology

Key words: drebrins, lymphocytes, tumor-infiltrating, lung neoplasms, tumor microenvironment, prognosis

Organism: Human

Tissue: Lung

Pathological State: Cancer

796
Effects of a Phytogenic Supplement Containing Olive By-Product and Green Tea Extracts on Growth Performance, Lipid Metabolism, and Hepatic Antioxidant Capacity in Largemouth Bass (Micropterus salmoides) Fed a High Soybean Meal Diet

J Liu, M Xue, S Morais, M He, H Wang, J Wang, JJ Pastor, RA Gonçalves, X Liang

Antioxidants (MDPI) China, Spain, 07 December 2022

Zoology

Key words: largemouth bass, soybean meal, phytogenic feed additive, antioxidant capacity, lipid metabolism

Organism: Bass Fish

Tissue: Liver

797
Hybrid Transcytosis Nanopomegranates for Sensitizing Breast Cancer Radiotherapy in Deep Tumor Tissue

L Wang, L Xiao, Z Zhao, K Zhong, W Zhu, H Liu, X Li

Nano Research (Scipen) China, 07 December 2022

Oncology

Key words: Breast cancer, transcytosis, hybrid nanopomegranate, hypoxia alleviation, radiosensitization

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

798
HMGB1 Promotes In Vitro and In Vivo Skeletal Muscle Atrophy through an IL-18-Dependent Mechanism

TL Ho, CH Tang, SLY Chang, CH Tsai, HT Chen, CM Su

Cells (MDPI) Taiwan, 06 December 2022

Pharmacology

Key words: HMGB1, IL-18, inflammation, myogenesis, skeletal muscle atrophy

Organism: Mouse

Tissue: Muscle

799
Role of Artificial Intelligence in Cancer Diagnosis and Drug Development

S Srivastava, D Paliwal

Combinatorial Chemistry & High Throughput Screening (Ingenta conect) , 02 December 2022

Oncology

Key words: Cancer, artificial intelligence, computational approach, deep learning, drug development, machine learning

800
Sex-based difference in response to recombinant human bone morphogenetic protein-2 in a rat posterolateral fusion model

JP Foley, EJ Fred, S Minardi, JT Yamaguchi, AC Greene, AA Furman, JG Lyons, JT Paul, TS Nandurkar, KR Blank, RM Havey, M Muriuki, AG Patwardhan, WK Hsu, SR Stock, EL Hsu

Spine (Ingenta conect) USA, 01 December 2022

Key words: BMP, BMP-2, bone, healing, regeneration, rhBMP-2, sex, sex-dependent differences, spinal fusion, spine

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