Customer Publications (A total of 2600 papers published)

Immunoarchitectural patterns as potential prognostic factors for invasive ductal breast cancer

X Du, Z Zhou, Y Shao, K Qian, Y Wu, J Zhang, M Cui, J Wang, S Wang, Y Tai

npj Breast Cancer (Nature) China, 28 February 2022

Oncology

Key words: Breast cancer, Prognostic markers [more]

EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma

J Ingruber, J Dudás, D Savic, G Schweigl, TB Steinbichler, M do Carmo Greier, M Santer, S Carollo, Z Trajanoski, H Riechelmann

Experimental Cell Research (Elsevier) Austria, 25 February 2022

Oncology

Key words: Mesenchymal-to-epithelial transition, Cell-transfection, TissueFax, UPCI-SCC090, SCC25, FaDu [more]

Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus

JH Lee, C Ostalecki, T Oberstein, S Schierer, E Zinser, M Eberhardt, K Blume, B Plosnita, L Stich, H Bruns, R Coras, J Vera-Gonzales, M Maler, AS Baur

EBioMedicine (Elsevier) Germany, Austria, 25 February 2022

Neuroscience

Key words: Alzheimer's disease, Plasma extracellular vesicles, Choroid plexus, Hippocampus, Hyaluronan, Hyaluronic acid synthetase, Secretases, BACE, Aβ, APP [more]

Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms

X Guo, X Jin, K Han, S Kang, S Tian, X Lv, M Feng, H Zheng, Y Zuo, G Xu, M Hu, J Xu, P Lv, YZ Chang

Free Radical Biology and Medicine (Elsevier) China, 24 February 2022

Neuroscience

Key words: Iron, Ischemic stroke, Gliosis, Synaptic plasticity, Myelination, Nerve regeneration [more]

Tumor Necrosis Factor-α Mediates Lung Injury in the Early Phase of Endotoxemia

KY Chen, CY Chang, HJ Hsu, HJ Shih, IT Huang, HH Patel, CJ Huang

Pharmaceuticals (MDPI) Taiwan, Australia, 24 February 2022

Pulmonology

Key words: lung injury, endotoxin, cytokines, cytokine receptors, peptide, mice [more]

Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation

J Gao, H Mei, J Sun, H Li, Y Huang, Y Tang, L Duan, D Liu, Y Pang, Q Wang, Y Gao, K Song, J Zhao, C Zhang, J Liu

Advanced Biology (Wiley) China, Australia, 23 February 2022

SARS-CoV-2, Osteology

[more]

High farnesoid X receptor expression predicts favorable clinical outcomes in PD‑L1low/negative non‑small cell lung cancer patients receiving anti‑PD‑1‑based chemo‑immunotherapy

L Wang, X Xu, B Shang, J Sun, B Liang, X Wang, W You, S Jiang

International Journal of Oncology (Spandidos Publications) China, 23 February 2022

Oncology

Key words: Farnesoid X receptor, Predictor, anti‑PD‑1‑based, Chemo‑immunotherapy, Non‑small cell lung cancer, PD‑L1low/negative patients [more]

Prompt Antiviral Action of Pulmonary CD8+ TRM Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung

L Jiang, L Liu, M Zhang, L Zhang, C Zhu, Q He, L Ye, C Zhao, Z Li, J Xu, X Zhang

Frontiers in Immunology (Frontiers Media S.A.) China, 22 February 2022

Immunology

Key words: influenza, lung-resident memory CD8 T cells, IFN-γ, interferon-induced genes, inflammatory cytokines [more]

Meloxicam Inhibits Hepatocellular Carcinoma Progression and Enhances the Sensitivity of Immunotherapy via the MicroRNA-200/PD-L1 Pathway

S Guangshun, S Guoqiang, C Xin, K Xiangyi, Z Wubin, L Zhitao, Z Zhiying, C Hongyong, L Chengyu, X Yongxiang, T Weiwei

Journal of Oncology (Hindawi Publishing Corporation) China, 21 February 2022

Oncology

[more]

TSPAN6 is a suppressor of Ras-driven cancer

PO Humbert, TZ Pryjda, B Pranjic, A Farrell, K Fujikura, R de Matos Simoes, R Karim, I Kozieradzki, SJF Cronin, GG Neely, TF Meyer, A Hagelkruys, HE Richardson, JM Penninger

Oncogene (Nature) Australia, Austria, Germany, Canada, 19 February 2022

Oncology

Key words: Cancer genetic, Cell polarity, Growth factor signalling [more]

Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects

YH Chan, KN Ho, YC Lee, MJ Chou, WZ Lew, HM Huang, PC Lai, SW Feng

Stem Cell Research & Therapy (Springer) Taiwan, USA, 19 February 2022

Osteology

Key words: Melatonin, Dental pulp mesenchymal stem cells, Osteogenesis, COX2/NF-κB, p38/ERK signaling pathwaym, Bone regeneration, Calvarial bone defect [more]

The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

F Niu, P Han, J Zhang, Y She, L Yang, J Yu, M Zhuang, K Tang, Y Shi, B Yang, C Liu, B Peng, SJ Ji

Elife (eLife Sciences Publications) China, 18 February 2022

Neuroscience

[more]

Imaging net retrograde axonal transport in vivo: a physiological biomarker

PTJ Lee, Z Kennedy, Y Wang, Y Lu, C Cefaliello, Ö Uyan, CQ Song, BM da Cruz Godinho, Z Xu, M Rusckowski, W Xue, RH Brown

Annals of Neurology (Wiley) USA, 17 February 2022

Medical Imaging

[more]

Cordycerebroside A inhibits ICAM‐1‐dependent M1 monocyte adhesion to osteoarthritis synovial fibroblasts

KT Lee, CH Su, SC Liu, BC Chen, JW Chang, CH Tsai, WC Huang, CJ Hsu, WC Chen, YC Wu, CH Tang

Journal of Food Biochemistry (Wiley) Taiwan, 15 February 2022

Rheumatology

Key words: Adhesion, Cordycerebroside A, ICAM-1, M1 macrophage, Osteoarthritis [more]

Quantitative Characterization of Macrophage, Lymphocyte, and Neutrophil Subtypes Within the Foreign Body Granuloma of Human Mesh Explants by 5-Marker Multiplex Fluorescence Microscopy

U Klinge, A Dievernich, J Stegmaier

Frontiers in Medicine (Frontiers Media S.A.) Germany, 15 February 2022

Medical Image Analysis

Key words: Foreign body granuloma, Mesh, Multiplex, Fluorescence, Macrophage, Lymphocyte, Neutrophil [more]

A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+ CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy

D Wang, J Fang, S Wen, Q Li, J Wang, L Yang, W Dai, H Lu, J Guo, Z Shan, W Xie, X Liu, L Wen, J Shen, A Wang, Q Chen, Z Wang

International Journal of Oral Science (Nature) China, 14 February 2022

Oncology

Key words: Cancer microenvironment, Head and neck cancer [more]

Cell-Penetrating Botulinum Neurotoxin Type A With Improved Cellular Uptake and Therapeutic Index

X Wei, L Li, Y Wu, J Liu

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) China, 11 February 2022

Biological Methods, Neuroscience

Key words: Cell-penetrating peptides, Zinc finger proteins, Botulinum neurotoxin type A, Cellular uptake, Therapeutic index [more]

H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice

L Ruilian, Q Honglin, X Jun, L Jianxin, B Qingyun, C Yilin, M Haifeng

Journal of Affective Disorders (Elsevier) China, 10 February 2022

Neuroscience

Key words: Chronic stress stimulated depression model, Hippocampus, Hydrogen sulfide, Inflammatory, Aerobic exercise [more]

The effects of hypoxia on mitochondrial function and metabolism in gastric cancer cells

J Jiang, Y Jiang, YG Zhang, T Zhang, JH Li, DL Huang, J Hou, MY Tian, L Sun, XM Su, Y Dong, YY Ma

Translational Cancer Research (AME Publishing Company) China, 10 February 2022

Oncology

Key words: Gastric cancer, Hypoxia, Mitochondrial function, Aerobic respiration [more]

MYC/MAX-Activated LINC00958 Promotes Lung Adenocarcinoma by Oncogenic Transcriptional Reprogramming Through HOXA1 Activation.

T Zhang, F Su, YB Lu, XL Ling, HY Dai, TN Yang, B Zhang, D Zhao, XM Hou

Frontiers in Oncology (Frontiers Media S.A.) China, 09 February 2022

Oncology

Key words: Lung adenocarcinoma, LINC00958, MYC, MAX, Transcriptional reprogramming, HOXA1 [more]

Colonic Leucine-Rich Repeat Kinase 2 Expression Is Increased and Associated With Disease Severity in Patients With Parkinson's Disease

PH Liao, HL Chiang, CT Shun, JF Hang, HM Chiu, MS Wu, CH Lin

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 08 February 2022

Neuroscience

Key words: Parkinson's disease, Colon biopsy, Leucine-rich repeat kinase 2, Inflammatory bowel diseases, Biomarker (BM) [more]

Differential localization and limited cytotoxic potential of duodenal CD8+ T cells

L Mvaya, T Khaba, AE Lakudzala, T Nkosi, N Jambo, I Kadwala, A Kankwatira, PD Patel, MA Gordon, TS Nyirenda, KC Jambo, ZM Ndhlovu

JCI Insight (American Society for Clinical Investigation) Malawi, South Africa, UK, USA, 08 February 2022

Immunology

[more]

Assessment of Physiological Rat Kidney Ageing—Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation

A Baumgartner, S Reichelt-Wurm, W Gronwald, C Samol, JA Schröder, C Fellner, K Holler, A Steege, FJ Putz, PJ Oefner, B Banas, MC Banas

Metabolites (MDPI) Germany, 08 February 2022

Transplantation Medicine, Nephrology

Key words: Kidney, Ageing, Transplantation, Inflammation, Urinary metabolites [more]

ATP8B1 Knockdown Activated the Choline Metabolism Pathway and Induced High-Level Intracellular REDOX Homeostasis in Lung Squamous Cell Carcinoma

X Zhang, R Zhang, P Liu, R Zhang, J Ning, Y Ye, W Yu, J Yu

Cancers (MDPI) China, 07 February 2022

Oncology

Key words: ATP8B1, LUSC, CHKA, REDOX [more]

Multi-Factorial Nerve Guidance Conduit Engineering Improves Outcomes in Inflammation, Angiogenesis and Large Defect Nerve Repair

AJ Hibbitts, Z Kočí, S Kneafsey, A Matsiko, L Žilić, A Dervan, P Hinton, G Chen, B Cavanagh, JK Dowling, CE McCoy, CT Buckley, SJ Archibald, FJ O'Brien

Matrix Biology (Elsevier) Ireland, USA, 04 February 2022

Neuroscience

Key words: Peripheral Nerve, Biomaterials, Extracellular Matrix, Nerve Guidance Conduit, Angiogenesis, Inflammation [more]

Effect of Helicobacter pylori-associated chronic gastritis on autonomous activity and sleep quality in mice

H Liu, W Zheng, L Zhang, T Lin, Y Tang, L Hu

Frontiers in Pharmacology (Frontiers Media S.A.) China, 04 February 2022

Microbiology, Gastroenterology

Key words: Autonomous activity, Chronic gastritis, Helicobacter pylori, Mouse behavior, Sleep quality [more]

Tegaserod Maleate Inhibits Breast Cancer Progression and Enhances the Sensitivity of Immunotherapy

X Li, L Wu, Z Zheng, H Liu, H Li, G Sun, G Sun, Y Cheng, H Wang, Z Li, J Shi, W Tang

Journal of Oncology (Hindawi Publishing Corporation) China, Germany, 03 February 2022

Oncology, Pharmacology

[more]

Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR Publications) USA, 02 February 2022

Oncology, Immunology

[more]

Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues

M Tsuda, R Horio, L Wang, T Takenami, J Moriya, J Suzuka, H Sugino, Z Tanei, M Tanino, S Tanaka

Scientific Reports (Nature) Japan, 02 February 2022

Biological Methods

Key words: Assay systems, Biotechnology [more]

Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond

S Chen, W Li, X Zheng, P Yu, P Wang, Z Sun, Y Xu, D Jiao, X Ye, M Cai, M Shen, M Wang, Q Zhang, F Kong, Y Wang, J He, H Wei, F Shi, J Du

PNAS (United States National Academy of Sciences) China, 01 February 2022

Oncology

Key words: Tumor Tissue, Histological Magnetometry, Nitrogen-Vacancy Center, Micrometer-Resolution Magnetic Imaging, Absolute Magnetic Quantification [more]

PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through β-catenin dysregulation

BY Ahn, MH Jeong, JH Pyun, HJ Jeong, TA Vuong, JH Bae, S An, SW Kim, YK Kim, D Ryu, HJ Kim, H Cho, GU Bae, JS Kang

Cellular and Molecular Life Sciences (Springer) South Korea, 28 January 2022

Cardiology

Key words: PRMT7, Cardiomyopathy, Wnt, β-catenin [more]

Regorafenib enhances antitumor immune efficacy of anti-PD-L1 immunotherapy on oral squamous cell carcinoma

IT Chiang, YH Lee, ZL Tan, FT Hsu, HF Tu

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 26 January 2022

Oncology, Pharmacology

Key words: Oral squamous cells carcinoma, Regorafenib, Anti-PD-L1, Antitumor-induced immunity [more]

Metastatic Tumor Antigen 1 Contributes to Hepatocarcinogenesis Posttranscriptionally Through Novel RNA Binding Function

YT Li, CJ Liu, JH Kao, LF Lin, HC Tu, CC Wang, PH Huang, HR Cheng, PJ Chen, DS Chen, HL Wu

Hepatology (Wiley) Taiwan, 24 January 2022

Oncology

Key words: RNA stability, Post-transcriptional control, Tumorigenic capacity, Self-renewal and anchorage-independent growth, Carcinogenesis [more]

A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach

D Douchi, A Yamamura, J Matsuo, JW Lee, N Nuttonmanit, Y Hui, M Lim, K Suda, M Shimura, S Chen, SC Pang, K Kohu, M Kaneko, H Kiyonari, A Kaneda, H Yoshida, I Taniuchi, M Osato, H Yang, M Unno, JBY So, KG Yeoh, LSH Chuang, SC Bae, Y Ito

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) Singapore, Japan, 21 January 2022

Stem Cell Research, Gastroenterology

Key words: Isthmus, Stem/Progenitor Cell, Enhanced Stem Cell Activity, Preneoplastic State, Gastric Carcinogenesis [more]

Inhibition of β-catenin signaling attenuates arteriovenous fistula thickening in mice by suppressing myofibroblasts

CT Liu, SC Hsu, HL Hsieh, CH Chen, CY Chen, YM Sue, TH Chen, YH Hsu, FY Lin, CM Shih, YT Shiu, PH Huang

Molecular Medicine (BMC) Taiwan, USA, 21 January 2022

Nephrology

Key words: Arteriovenous fistula (AVF), β-catenin, Hemodialysis, Myofibroblast [more]

Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT

N Kane, T Romero, S Diaz-Perez, MB Rettig, ML Steinberg, AU Kishan, D Schaue, RE Reiter, BS Knudsen, NG Nickols

Prostate Cancer and Prostatic Diseases (Nature) USA, 20 January 2022

Oncology

Key words: Cancer therapy, Prostate cancer [more]

Chidamide and mitomycin C exert synergistic cytotoxic effects against bladder cancer cells in vitro and suppress tumor growth in a rat bladder cancer model

SC Wang, CY Yu, YC Wu, YC Chang, SL Chen, WW Sung

Cancer Letters (Elsevier) Taiwan, 18 January 2022

Oncology

Key words: Urothelial carcinoma, Histone, N-methyl-N-nitrosourea, Deacetylase, Axl [more]

Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response

AM Gamage, KS Tan, WOY Chan, ZZR Lew, J Liu, CW Tan, D Rajagopalan, QXX Lin, LM Tan, PN Venkatesh, YW Ong, M Thong, RTP Lin, S Prabhakar, DY Wang, LF Wang

mBio (American Society for Microbiology) Singapore, 18 January 2022

SARS-CoV-2, Immunology

[more]

Repair phase modeling of ischemic acute kidney injury: recovery vs. transition to chronic kidney disease

K Lee, HR Jang, J Jeon, KE Yang, JE Lee, GY Kwon, DJ Kim, W Huh

American Journal of Translational Research (e-Century Publishing Corporation) South Korea, 15 January 2022

Nephrology

Key words: Ischemic acute kidney injury, Chronic kidney disease, Ischemia-reperfusion injury, Recovery, Repair [more]

P2RX7 in dopaminergic neurons of ventral periaqueductal gray mediates HTWP acupuncture-induced consciousness in traumatic brain injury

H Tang, S Qin, W Li, X Chen, L Ulloa, Q Zhu, B Liu, Y Gong, Y Zhao, S Wang, S Li, Y Guo, Z Xu, Y Guo

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China, USA, 13 January 2022

Neuroscience

Key words: Acupuncture, Traumatic Brain Injury, Neural Projection, Dopamine, P2RX7, Ventral Periaqueductal Gray, Hand 12 Jing-Well Points [more]

Cottonseed protein concentrate as fishmeal alternative for largemouth bass (Micropterus salmoides) supplemented a yeast-based paraprobiotic: Effects on growth performance, gut health and microbiome

X Xie, J Wang, Y Guan, S Xing, X Liang, M Xue, J Wang, Y Chang, E Leclercq

Aquaculture (Elsevier) China, France, 13 January 2022

Zoology

Key words: Cottonseed Protein Concentrate, Largemouth Bass, Paraprobiotic, Gut Health, Gut Microbiome [more]

Autochthonous Human Dirofilaria repens Infection in Austria

N Geissler, J Ruff, J Walochnik, W Ludwig, H Auer, U Wiedermann, W Geissler

Acta Parasitologica (Springer) Austria, 12 January 2022

Parasitology

Key words: Dirofilariasis · Nematode infections · Parasitic worms · Climate change · Austria [more]

Large deletion of Wdr19 in developing renal tubules disrupts primary ciliogenesis leading to polycystic kidney disease in mice

SS Yu, E Wang, CY Chiang, PH Cheng, YS Yeh, YY Wu, YY Chiou, ST Jiang

The Journal of Pathology (Wiley) Taiwan, 10 January 2022

Nephrology

Key words: Wdr19, intraflagellar transport, primary cilia, renal cyst, polycystic kidney disease [more]

Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease

HC Campos, DE Ribeiro, D Hashiguchi, DY Hukuda, C Gimenes, SAA Romariz, Q Ye, Y Tang, H Ulrich, B Monteiro Longo

Stem Cell Reviews and Reports (Springer) Brazil, China, 08 January 2022

Neuroscience, Stem Cell Research

Key words: Alzheimer's Disease, Hippocampus, Neural and Mesenchymal Stem Cell Transplantation, Tissue Cytometry, Amyloid-β plaques [more]

Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin

W Vankrunkelsven, S Derde, J Gunst, S Vander Perre, E Declerck, L Pauwels, I Derese, G Van den Berghe, L Langouche

Journal of Cachexia, Sarcopenia and Muscle (Wiley) Belgium, 07 January 2022

Infectious Diseases, Endocrinology

Key words: Leptin, Critical Illness, Sepsis, Muscle Weakness, Intensive Care Unit Acquired Weakness, Atrophy, Protein Catabolism [more]

Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection

FJ Ogunshola, W Smidt, AF Naidoo, TP Nkosi, T Ngubane, PT Khaba, OO Baiyegunhi, B Mahlobo, S Rasehlo, N Ngema, I Jajbhay, KL Dong, V Ramsuran, J Pansegrouw, T Ndung'u, B Walker, T de Oliveria, ZM Ndhlovu

Blood Advances (ASH Publications) South Africa, USA, Germany, 06 January 2022

Immunology

Key words: Immunobiology, Immunotherapy [more]

Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity

H Wang, Y Fan, W Chen, Z Lv, S Wu, Y Xuan, Chenfeng Wang, Yongliang Lu,Tao Guo,Donglai Shen,Fan Zhang,Qingbo Huang,Yu Gao,Hongzhao Li,Xin Ma,Baojun Wang,Yan Huang &Xu Zhang

OncoImmunology (Taylor & Francis) China, 05 January 2022

Oncology

Key words: CMTM6, DNA Damage, Cellular Senescence, Immunity, Renal Cell Carcinoma [more]

SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages

Z Wang, J Lv, P Yu, Y Qu, Y Zhou, L Zhou, Q Zhu, S Li, J Song, W Deng, R Gao, Y Liu, J Liu, WM Tong, C Qin, B Huang

Cellular & molecular Immunology (Nature) China, 04 January 2022

SARS-CoV-2, Immunology

Key words: SARS-CoV-2, Microparticles, Alveolar Macrophages, Endosomes, Lysosomes [more]

Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes

CL Ho, LLH Huang, SJ Shieh

Regenerative Biomaterials (Chinese Society for Biomaterials) Taiwan, 04 January 2022

Stem Cell Research

Key words: Chondrocytes, Cell Proliferation, Perichondrial Progenitor Cells, Paracrine Effect, Neocartilage Formation [more]

Stabilization but no functional influence of HIF-1α expression in the intestinal epithelium during Salmonella Typhimurium infection

L Robrahn, A Dupont, S Jumpertz, K Zhang, CH Holland, J Guillaume, S rappold, J Roth, V Cerovic, J Saez-Rodriguez, MW Hornef, T Cramer

Infection and Immunity (American Society for Microbiology) Germany, The Netherlands, 03 January 2022

Immunology, Microbiology

[more]

Preclinical Safety of a 3D-Printed Hydroxyapatite-Demineralized Bone Matrix Scaffold for Spinal Fusion

M Plantz, J Lyons, JT Yamaguchi, AC Greene, DJ Ellenbogen, MJ Hallman, V Shah, C Yun, AE Jakus, D Procissi, S Minardi, RN Shah, WK Hsu, EL Hsu

Spine (ingentaconnect) USA, 01 January 2022

Osteology

Key words: 3D Printing, Bone Morphogenetic Protein-2, Demineralized Bone Matrix, Host Inflammatory Response, Hydroxyapatite, Spinal Fusion [more]

Detection of Cytopathic Effects Induced by Influenza, Parainfluenza, and Enterovirus Using Deep Convolution Neural Network

JJ Chen, PH Lin, YY Lin, KY Pu, CF Wang, SY Lin, TS Chen

Biomedicines (MDPI) Taiwan, 28 December 2021

Machine Learning, Virology

Key words: Artificial Intelligence, Cytopathic Effect, ResNet-50

The liquid Kangfuxin (KFX) has efficient antifungal activity and can be used in the treatment of vulvovaginal candidiasis in mouse

J Ma, YC Yang, LQ Su, DM Qin, K Yuan, Y Zhang, RR Wang

Letters in Applied Microbiology (Wiley) China, 27 December 2021

Infectious Diseases, Reproductive Medicine

Key words: Candida Albicans, Kangfuxin Liquid, Antifungal, Vaginal Candidiasis, Murine Model [more]

Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

CY Chang, KY Chen, HJ Shih, M Chiang, IT Huang, YH Huang, CJ Huang

Pharmaceuticals (MDPI) Taiwan, 27 December 2021

Endocrinology

Key words: Obesity, Sepsis, Liver, Exosomes, let-7i [more]

Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis

J Zhang, L Wang, C Li, H Zhang, R Li, M Li

Systems biology in Reproductive Medicine (Taylor & Francis) China, 27 December 2021

Reproductive Medicine

Key words: Letrozole, Endometriosis, Endometrial Receptivity, Integrin avβ3, HOXA10 [more]

Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells

K Piatek, A Kutner, D Cacsire Castillo-Tong, T Manhardt, N Kupper, U Nowak, M Chodyński, E Marcinkowska, E Kallay, M Schepelmann

International Journal of Molecular Sciences (MDPI) Austria, Poland, 24 December 2021

Endocrinology, Oncology

Key words: Vitamin D, Vitamin D Analogs, 25 Vitamin D 24-Hydroxylase, CYP24A1, Proliferation, High-Grade Serous Ovarian Cancer Cells [more]

Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression

YH Chu, WC Liao, YJ Ho, CH Huang, TJ Tseng, CH Liu

Cells (MDPI) Taiwan, 20 December 2021

Oncology

Key words: Glioma, Chondroitin Sulfate, CHSY1, Integrin Β1, CD44, Therapeutic Peptide

S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 MAPK Pathways

K Tanigawa, S Tsukamoto, Y Koma, Y Kitamura, S Urakami, M Shimizu, M Fujikawa, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki

The American Journal of Pathology (Elsevier) Japan, 20 December 2021

Oncology

[more]

Spatial point pattern analysis identifies mechanisms shaping the skin parasite landscape in Leishmania donovani infection

JSP Doehl, H Ashwin, N Brown, A Romano, S Carmichael, JW Pitchford, PM Kaye

Frontiers in Immunology (Frontiers Media S.A.) UK, 16 December 2021

Parasitology

Key words: Leishmania donovani, host cell, dispersion, dispersal, skin patches, spatial point pattern analysis [more]

P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease

Y Li, H Zhang, J Yang, M Zhan, X Hu, Y Liu, L Yu, X Yan, S Liang, R Zhang, Y Lu, B Li, C Liu, M Li

Chinese Medicine (Springer) China, 16 December 2021

Gastroenterology

Key words: P2Y12 Receptor, Visceral Pain, Depression, EA, IBD [more]

Hedgehog-signalling in papillary fibroblasts is essential for hair follicle regeneration during wound healing

S Frech, A Forsthuber, A Korosec, K Lipp, V Kozumov, BM Lichtenberger

Journal of Investigative Dermatology (Elsevier) Austria, 16 December 2021

Dermatology

Key words: Wound Healing, Dermal Fibroblast Lineages, Hedgehog Signaling, Hair Follicle Neogenesis, WIHN, Papillary and Reticular Fibroblasts, Regeneration [more]

Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma

C Wang, Y Huang, X Ma, B Wang, X Zhang

International Journal of Immunpathology and Pharmacology (SAGE Journals) China, 15 December 2021

Oncology

Key words: Clear Cell Renal Cell Carcinoma, NEK2, Prognosis [more]

CD163+ M2 macrophages promote fibrosis in IgG4‐related disease via TLR7/IRAK4/NF‐κB signaling

A Chinju, M Moriyama, N Kakizoe-Ishiguro, H Chen,Y Miyahara, AR Haque, K Furusho, M Sakamoto, K Kai, K Kibe, S Hatakeyama-Furukawa, M Ito-Ohta, T Maehara, S Nakamura

Arthritis & Rheumatology (Wiley) Japan, Bangladesh, 15 December 2021

Immunology, Rheumatology

Key words: Igg4-Related Disease, M2 Macrophage, Toll-Like Receptor 7, IL-1 Receptor-Associated Kinase 4, Fibrosis [more]

Nuplazid suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting PAK4

Y Wei, W Wu, Y Jiang, H Zhou, Y Yu, L Zhao, X Wu, X Lu, Q Yuan, Z Wang, Z Dong, L He, J Zhao, K Liu

British Journal of Cancer (Nature) China, 15 December 2021

Oncology

Key words: Cancer Prevention [more]

A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice

K Cao, X Wang, H Peng, L Ding, X Wang, Y Hu, L Dong, T Yang, X Hong, M Xing, D Li, C Zhu, X He, C Zhao, P Zhao, D Zhou, X Zhang, J Xu

Journal of Virology (American Society for Microbiology) China, 15 December 2021

SARS-CoV-2

Key words: COVID-19, Vaccine, SARS-CoV-2 Variants, Influenza, Adenoviral Vector [more]

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development

T Wang, J Zhang, N Li, M Li, S Ma, S Tan, X Guo, Z Wang, Z Wu, L Gao, C Ma, X Liang

Molecular Therapy (Cell Press) China, 15 December 2021

Oncology

Key words: Tim-3, Tim-3 Ligands, Immune Checkpoint Blockade, Tumor Microenvironment, Multiplexed Immunofluorescence [more]

Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response

YT Yen, M Chien, PY Wu, CC Ho, CT Ho, KCY Huang, SF Chiang, KSC Chau, WTL Chen, SC Hung

Nature Communications (Nature) Taiwan, 15 December 2021

Oncology, Immunology

Key words: Cancer Immunotherapy, Colon Cancer, Gene Silencing, Immunoediting [more]

Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

J Chen, J Fan, Z Chen, M Zhang, H Peng, J Liu, L Ding, M Liu, C Zhao, P Zhao, S Zhang, X Zhang, J Xu

PNAS (United States National Academy of Sciences) China, 14 December 2021

SARS-CoV-2

[more]

Polypharmacological reprogramming of tumor-associated macrophages towards an inflammatory phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR Publications) USA, 13 December 2021

Oncology

Key words: Tumor-Associated Macrophage, Breast Cancer, Tumor Microenvironment, Kinase Inhibitor Screening, Cell-Cell Interaction [more]

The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model

A Kannan, S Minardi, DJ Ellenbogen, MJ Hallman, AC Greene, JT Yamaguchi, MA Plantz, S Jeong, KC Sana, V Shah, C Yun, EL Hsu, WK Hsu

JOR Spine (Wiley) USA, 13 December 2021

Rheumatology

Key words: Local Steroid, Osteogenesis, Pseudarthrosis, Spine Fusion [more]

The plasminogen receptor Plg‐RKT regulates adipose function and metabolic homeostasis

F Samad, H Bai, N Baik, P Haider, Y Zhang, G Rega-Kaun, C Kaun, M Prager, J Wojta, Q Bui, S Chakrabarty, J Wang, RJ Parmer, LA Miles

Journal of Thrombosis and Haemostasis (Wiley) USA, Austria, 12 December 2021

Endocrinology

Key words: Adipose Inflammation, Hepatic Steatosis, Insulin Resistance, Obesity, Plg-RKT [more]

Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension

Z Zhao, Z Guo, Z Yin, Y Qiu, B Zhou

Frontiers in Physiology (Frontiers Media S.A.) China, 10 December 2021

Gastroenterology

Key words: Intra-Abdominal Hypertension, Abdominal Compartment Syndrome, Fecal Microbiota Transplantation, 16S rRNA, Gut Microbiota Dysbiosis [more]

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

T Zhang, L Sun, Y Hao, C Suo, S Shen, H Wei, W Ma, P Zhang, T Wang, X Gu, ST Li, Z Chen, R Yan, Y Zhang, Y Cai, R Zhou, W Jia, F Huang, P Gao, H Zhang

Nature Cancer (Nature) China, 09 December 2021

Oncology

[more]

FGL1 as a Novel Mediator and Biomarker of Malignant Progression in Clear Cell Renal Cell Carcinoma.

Z Lv, B Cui, X Huang, HY Feng, T Wang, HF Wang, YD Xuan, HZ Li, X Ma, Y Huang, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 09 December 2021

Oncology

Key words: biomarker, clear cell renal cell carcinoma, epithelial to mesenchymal transition, fibrinogen-like protein 1, progression [more]

CD146 as a Prognostic-Related Biomarker in ccRCC Correlating With Immune Infiltrates

Z Lv, HY Feng, W Tao, HZ Li, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 08 December 2021

Oncology

Key words: CD146, ccRCC, prognosis, methylation, tumor microenvironment [more]

Lipid Droplet-Specific Probe for Rapidly Locating Atherosclerotic Plaques and Intraoperative Imaging via In Situ Spraying

M Sang, B Cai, S Qin, S Zhao, Y Mao, Y Wang, X Yu, J Zheng

ACS Applied Materials & Interfaces (ACS Publications) China, 06 December 2021

Biological Methods

Key words: Lipids, Liquids, Fluorescence, Fluorescence Imaging, Probes [more]

Hedgehog signaling controls bone homeostasis by regulating osteogenic/adipogenic fate of skeletal stem/progenitor cells in mice

L Zhang, X Fu, L Ni, C Liu, Y Zheng, H You, M Li, C Xiu, L Zhang, T Gong, N Luo, Z Zhang, G He, S Hu, H Yang, D Chen, J Chen

Journal of Bone and Mineral Research (Wiley) China, 06 December 2021

Osteology, Stem Cell Research

Key words: Genetic Animal Models, Hedgehogs, Stromal/Stem Cells, Osteoporosis, Aging [more]

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

JL Zhang, YH Li, LL Wang, HQ Liu, SY Lu, Y Liu, K Li, B Liu, SY Li, FM Shao, K Wang, N Sheng, R Li, JJ Cui, PC Sun, CX Ma, B Zhu, Z Wang, YH Wan, SS Yu, Y Che, CY Wang, C Wang, Q Zhang, LM Zhao, XZ Peng, Z Cheng, JB Chang, JD Jiang

Signal Transduction and Targeted Therapy (Nature) China, 06 December 2021

SARS-CoV-2

Key words: Drug Development, Infectious Diseases [more]

Ascorbic acid-2 glucoside mitigates intestinal damage during pelvic radiotherapy in a rat bladder tumor model

Y Ito, T Yamamoto, K Miyai, J Take, H Scherthan, A Rommel, S Eder, K Steinestel, A Rump, M Port, N Shinomiya, M Kinoshita

International Journal of Radiation Biology (Taylor & Francis) Japan, Germany, 06 December 2021

Oncology, Radiotherapy

Key words: AY-27 Cells, DNA Damage, 53BP1, CD163, M1/M2, Macrophages [more]

Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration

M Zou, L Gong, Q Ke, R Qi, X Zhu, W Liu, Q Sun, X Tang, Z Luo, X Gong, Y Liu, DWC Li

Free Radical Biology and Medicine (Elsevier) China, 04 December 2021

Cell Biology

Key words: Age-Related Macular Degeneration, Heterochromatin, Inflammation, Methotrexate, cGAS, STING [more]

Defect of LSS Disrupts Lens Development in Cataractogenesis.

M Zhao, T Mei, B Shang, B Zou, Q Lian, W Xu, K Wu, Y Lai, C Liu, L Wei, J Zhu, K Zhang, Y Liu, L Zhao

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 02 December 2021

Developmental Biology

Key words: lanosterol synthase, congenital cataract, mouse model, mutation, lens development [more]

Mad2 Induced Aneuploidy Contributes to Eml4-Alk Driven Lung Cancer by Generating an Immunosuppressive Environment

K Alikhanyan, Y Chen, K Somogyi, S Kraut, R Sotillo

Cancers (MDPI) Germany, 30 November 2021

Oncology

Key words: Lung Cancer, Aneuploidy, Tumor Microenvironment, Immune Suppression, Mouse Models [more]

Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1

A Lo, K Holmes, S Kamlapurkar, F Mundt, S Moorthi, I Fung, S Fereshetian, J Watson, SA Carr, P Mertins, AH Berger

Science Signaling (Science) USA, 30 November 2021

Oncology

[more]

Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy

A Dodd, AA Natfji, A Evangelinos, A Grigoletto, G Pasut, F Beards, L Renshall, HMI Osborn, F Greco, LK Harris

Molecular Pharmaceutics (ACS Publications) UK, Italy, 29 November 2021

Pharmacology

Key words: Polymer−Drug Conjugate PEG Pregnancy Placenta Transport Drug Delivery [more]

ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

VA Arrieta, AX Chen, JR Kane, SJ Kang, C Kassab, C Dmello, J Zhao, KB Burdett, PS Upadhyayula, C Lee-Chang, J Shilati, D Jaishankar, L Chen, A Gould, D Zhang, J Yuan, W Zhao, X Ling, JK Burks, B Laffleur, C Amidei, JN Bruce, RV Lukas, JT Yamaguchi, D Cieremans, G Rothschild, U Basu, M McCord, DJ Brat, H Zhang, LAD Cooper, B Zhang, P Sims, TF Cloughesy, R Prins, P Canoll, R Stupp, AB Heimberger, C Horbinski, FM Iwamoto, R Rabadan, AM Sonabend

Nature Cancer (Nature) USA, Mexico, France, 29 November 2021

Oncology

Key words: Cancer, Cancer Immunotherapy, CNS Cancer, Tumour Biomarkers [more]

Single cell imaging-based chromatin biomarkers for tumor progression

S Venkatachalapathy, DS Jokhun, M Andhari, GV Shivashankar

Scientific Reports (Nature) Singapore, India, Italy, Switzerland, 29 November 2021

Oncology

Key words: Biomarkers, Biophysics, Cancer, Computational Biology and Bioinformatics [more]

Lipid‐Activatable Fluorescent Probe for Intraoperative Imaging of Atherosclerotic Plaque Using In Situ Patch

J Zheng, S Zhao, Y Mao, Z Du, G Li, M Sang

Nano Micro Small (Wiley) China, 27 November 2021

Biological Methods

[more]

HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

C Da, J Pu, Z Liu, J Wei, Y Qu, Y Wu, B Shi, J Yang, N He, P Hou

Signal Transduction and Targeted Therapy (Nature) China, 24 November 2021

Oncology

Key words: Cancer, Molecular Biology [more]

Mechanism of Chronic Stress-Induced Glutamatergic Neuronal Damage in the Basolateral Amygdaloid Nucleus

S Wang, X Liu, W Shi, Q Qi, G Zhang, Y Li, B Cong, M Zuo

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 23 November 2021

Neuroscience

[more]

Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

C Wang, A Cui, M Bukenya, A Aung, D Pradhan, CA Whittaker, Y Agarwal, A Thomas, S Liang, P Amlashi, H Suh, S Spranger, N Hacohen, DJ Irvine

Cell Reports (Cell Press) USA, 23 November 2021

Immunology, Oncology

Key words: NK Cell, Macrophage, Checkpoint Blockade, Sensitization, Tumor-Targeting Antibody, Interleukin-2, Tumor Microenvironment, Vascular Normalization [more]

Pectins from various sources inhibit galectin-3-related cardiac fibrosis

AR van der Velde, WC Meijers, HHW Silljé, P Muntendam, MM Dokter, WH van Gilst, HA Schols, RA de Boer

Current Research in Translational Medicine (Elsevier) USA, The Netherlands, 23 November 2021

Cardiology

Key words: Galectin-3, Inhibitor, Pectin, Heart failure, Fibrosis, Affinity [more]

CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c. 1085 Genotypes

YM Yeh, PC Lin, WC Su, MR Shen

International Journal of Molecular Sciences (MDPI) Taiwan, 22 November 2021

Oncology

Key words: Colony-Stimulating Factor 1 Receptor, Genetic Variant, CD40, IL-2 Expression, Colorectal Cancer [more]

Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds

WH Tsai, CH Chou, TY Huang, HL Wang, PJ Chien, WW Chang, HT Lee

Cells (MDPI) Taiwan, 22 November 2021

Dermatology

Key words: Heat-Killed Probiotics, Lactobacillus, L. Plantarum, L. Paracasei, Skin Wound Healing, Lipoteichoic Acid [more]

Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin-and mucosa-resident memory T cells

S Saluzzo, RV Pandey, LM Gail, R Dingelmaier-Hovorka, L Kleissl, L Shaw, B Reininger, D Atzmüller, J Strobl, V Tonzeau-Römer, A Beer, C Staud, A Rieger, M Farlik, W Weninger, G Stingl, G Stary

Immunity (Cell Press) Austria, 22 November 2021

Immunology, Virology

Key words: HIV, Tissue-Resident Memory T Cells, Skin, Mucosal Immunity, HPV, Cancer, CXCR3 [more]

BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression

Q Wu, F Liu, M Ge, KV Laster, L Wei, R Du, M Jiang, J Zhang, Y Zhi, G Jin, S Zhao, DJ Kim, Z Dong, K Liu

Oncogene (Nature) China, 19 November 2021

Oncology

Key words: Oncogenes, Transcription [more]

Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca2+ …

R Wang, M Wang, B Liu, H Xu, J Ye, X Sun, G Sun

Biomedicine & Pharmacotherapy (Elsevier) China, 17 November 2021

Cardiology

Key words: calenduloside E, myocardial ischemia-reperfusion injury, L-type Ca2+ channels, BAG3, calcium overload, autophagy [more]

Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy

M Gao, Y Chen, C Wu

Bioengineered (Taylor & Francis) China, 16 November 2021

Nanomedicine, Oncology

Key words: Malignant Glioma, Doxorubicin-Loaded Nanoparticles, Chemosensitization, Tumor Chemotherapy, Size-Dependent [more]

HSBP1 Is a Novel Interactor of FIP200 and ATG13 That Promotes Autophagy Initiation and Picornavirus Replication

M Mauthe, N Dinesh Kumar, P Verlhac, N van de Beek, F Reggiori

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) The Netherlands, 15 November 2021

Virology

Key words: Autophagy, Infection, ULK Kinase Complex, EMCV, CVB3, EV71 [more]

Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells

KC Wei, YC Lin, CH Chen, YH Chu, CY Huang, WC Liao, CH Liu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, 15 November 2021

Oncology

Key words: Fucosyltransferase 8, Glioma, HGF, MET, EGFR [more]

Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

LC Wang, WY Wei, PC Ho, PY Wu, YP Chu, KJ Tsai

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 12 November 2021

Neuroscience

Key words: Cortical Electrical Stimulation, Neuromodulation, Ischemic Stroke, BDNF, PI3K – PKB/Akt Signaling Pathway [more]

TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma

EY Lee, M Kim, BK Choi, DH Kim, I Choi, HJ You

Molecules and Cells (Korean Society for Molecular and Cellular Biology) South Korea, 12 November 2021

Oncology

Key words: cytokines, leiomyosarcoma, tjp1, tumor microenvironment [more]

Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

AE Hinman, C Jani, SC Pringle, WR Zhang, N Jain, AJ Martinot, AK Barczak

eLife (eLife Sciences Publications) USA, 10 November 2021

Immunology, Microbiology

[more]

Dopamine D2 receptor regulates cortical synaptic pruning in rodents

YQ Zhang, WP Lin, LP Huang, B Zhao, CC Zhang, DM Yin

Nature Communications (Nature) China, 08 November 2021

Neuroscience

Key words: Diseases of The Nervous System, Molecular Neuroscience, Spine Regulation and Structure, Synaptic Development [more]

IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1

WJ Wu, SH Wang, CC Wu, YA Su, CY Chiang, CH Lai, TH Wang, TL Cheng, JY Kuo, TC Hsu, TH Lin, YJ Lee

International Journal of Molecular Sciences (MDPI) Taiwan, 05 November 2021

Reproductive Medicine

Key words: IL-4, IL-13, Mammary Glands, Cell Proliferation, STAT6, IRS Protein [more]

Donor Bone Marrow Derived Macrophage Engraftment into the Central Nervous System of Allogeneic Transplant Patients

AM Loeb, SS Pattwell, A Bedalov, S Meshinchi, KR Loeb

Blood (ASH Publications) USA, 05 November 2021

Hematology

[more]

Cholesterol-lowering Intervention Decreases mTOR Complex 2 Signaling and Enhanced Antitumor Immunity

Y Wang, S You, S Su, A Yeon, E Lo, S Kim, J Mohler, MR Freeman, HL Kim

Clinical Cancer Research (AACR Publications) USA, 02 November 2021

Oncology

[more]

Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

RJ Ni, YM Shu, T Li, JN Zhou

Frontiers in Neuroanatomy (Frontiers Media S.A.) China, 02 November 2021

Neuroscience

Key words: Caudate Nucleus, Putamen, Accumbens Nucleus, Thalamus, Neural Circuits [more]

Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals

S Fischer, E Nasyrov, M Brosien, KT Preissner, HM Marti, R Kunze

Journal of Neuroinflammation (BMC) Germany, 02 November 2021

Neuroscience

Key words: Extracellular RNA, Astrocyte, Inflammation, Stroke, Ischemia/Reperfusion, PAMP, DAMP, TLR [more]

Expression of Vascular Cell Adhesion Molecule-1 in Peripheral Artery Disease is Enriched in Patients with Advanced Kidney Disease

PT Lee, IC Liao, CH Lee, LW Hsu, PY Liu

Acta Cardiologica Sinica (Taiwan Society of Cardiology) Taiwan, 01 November 2021

Cardiology

Key words: Chronic Kidney Disease, Hemodialysis [more]

SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway

CY Kuo, YC Chang, MN Chien,

Endocrine-Related Cancer (Society for Endocrinology) Taiwan, 01 November 2021

Oncology

Key words: SREBP1, Invasion, Thyroid Cancer, Lipid Metabolism [more]

Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer

BL Horton, DM Morgan, N Momin, M Zagorulya, E Torres-Mejia, V Bhandarkar, KD Wittrup, JC Love, S Spranger

Science Immunology (Science) USA, 29 October 2021

Oncology, Immunology

[more]

Spatiotemporal Protein Expression Profiles of QSOX1 in the Murine Uterus, Placenta, and Embryo during Pregnancy

HS Lin, RKK Lee, TH Yang, HW Fang, SH Li

Applied Sciences (MDPI) Taiwan, 29 October 2021

Reproductive Medicine

Key words: Quiescin Sulfhydryl Oxidase 1, Uterus, Placenta, Embryo, Maternal-Fetal Interface, Tissue Distribution, Pregnancy [more]

SPION NANOPARTICLES IN VITRO AND IN VIVOTESTING FOR ANTIMELANOMA DRUG RELEASE INTO TUMORS

M Doni, HF Oancea, HRC Fierăscu

The International Symposium PRIOrities of CHEMistry for a sustainable development (ICECHIM) Romania, 29 October 2021

Oncology, Nanomedicine

Key words: melanoma cells, syngeneic melanoma mouse model, drug delivery, IHC, RT-qPCR [more]

Carboxypeptidase N1 is anticipated to be a synergy metrics for chemotherapy effectiveness and prognostic significance in invasive breast cancer

YY Fan, CH Liu, AL Wu, HC Chen, YJ Hsueh, KJ Chen, CC Lai, CY Huang, WC Wu

Cancer Cell International (Springer) China, 28 October 2021

Oncology

Key words: Carboxypeptidase N1, CA153, Chemotherapeutic Efficacy, Prognosis, Invasive Breast Cancer [more]

Increased osteogenic activity of dynamic cultured composite bone scaffolds: Characterization and in vitro study

ML Mueller, MP Ottensmeyer, JR Thamm, R Schmelzeisen, MJ Troulis, FPS Guastaldi

Journal of Oral and Maxillofacial Surgery (Elsevier) USA, Germany, 27 October 2021

Osteology

Key words: Scaffolds, Bone Tissue Engineering, Calcium Phosphate, 3D Printing, ALP [more]

Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer

PF Yueh, YH Lee, I Chiang, WT Chen, KL Lan, CH Chen, FT Hsu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, USA, 26 October 2021

Oncology

Key words: Imipramine, Non-Small Cell Lung Cancer (NSCLC), EGFR - Epidermal Growth Factor Receptor, PKC-δ-Protein Kinase C Delta, NF-κB – Nuclear Factor Kappa B [more]

The prognostic value of TCF1+ CD8+ T in primary small cell carcinoma of the esophagus

L Ma, L Sun, K Zhao, Z Dong, Z Huang, X Meng

Cancer Science (Japanese Cancer Association) China, 25 October 2021

Oncology

Key words: prognosis, PSCCE, stem‐like, TCF1, tumor microenvironment [more]

Metabolic memory underlying minimal residual disease in breast cancer

K Radic Shechter, E Kafkia, K Zirngibl, S Gawrzak, A Alladin, D Machado, C Lüchtenborg, DC Sevin, B Brügger, KR Patil, M Jechlinger

Molecular Systems Biology (EMBO press) Germany, UK, 25 October 2021

Oncology

[more]

Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction

LJ Renshall, F Beards, A Evangelinos, SL Greenwood, P Brownbill, A Stevens, CP Sibley, JD Aplin, ED Johnstone, T Teesalu, LK Harris

Pharmaceutics (MDPI) UK, USA, 25 October 2021

Reproductive Medicine

Key words: Placenta, Pregnancy, Fetal Growth Restriction, LLiposomes, Epidermal Growth Factor [more]

Cardiac Fibrosis Is a Risk Factor for Severe COVID-19

J Mustroph, J Hupf, MJ Baier, K Evert, C Brochhausen, K Broeker, C Meindl, B Seither, C Jungbauer, M Evert, LS Maier, S Wagner

Frontiers in Immunology (Frontiers Media S.A.) Germany, 22 October 2021

SARS-CoV-2

Key words: SARS-CoV-2, COVID-19, Fibrosis, Heart, TGF-β1, NRP-1 [more]

Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist

H Mei, Z Zha, W Wang, Y Xie, Y Huang, W Li, D Wei, X Zhang, J Qu, J Liu

Genome Biology (BMC) China, 22 October 2021

Genetics

Key words: CRISPR, Genome-wide screen, Surfaceome screen, Rhinovirus, OLFML3 [more]

Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

C Shen, R Li, R Negro, J Cheng, SM Vora, TM Fu, A Wang, K He, L Andreeva, P Gao, Z Tian, RA Flavell, S Zhu, H Wu

CELL (Cell Press) USA, China, Italy, 21 October 2021

Immunology, Virology

Key words: NLRP6, dsRNA, Liquid-Liquid Phase Separation, LLPS, Inflammasome, MHV, RV, IDRs [more]

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

C Vinel, G Rosser, L Guglielmi, M Constantinou, N Pomella, X Zhang, JR Boot, TA Jones, TO Millner, AA Dumas, V Rakyan, J Rees, JL Thompson, J Vuononvirta, S Nadkarni, TE Assan, N Aley, YY Lin, P Liu, S Nelander, D Sheer, CLR Merry F Marelli-Berg, S Brandner, S Marino

Nature Communications (Nature) UK, Hong Kong, Sweden, 21 October 2021

Oncology

Key words: CNS Cancer, Reprogramming [more]

KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements

SM Zhang, WL Cai, X Liu, D Thakral, J Luo, LH Chan, MK McGeary, E Song, KRM Blenman, G Micevic, S Jessel, Y Zhang, M Yin, CJ Booth, LB Jilaveanu, W Damsky, M Sznol, HM Kluger, A Iwasaki, MW Bosenberg, Q Yan

Nature (Nature) USA, China, 20 October 2021

Oncology

Key words: Epigenetics, Melanoma [more]

A Recurrent STAT5BN642H Driver Mutation in Feline Alimentary T Cell Lymphoma

M Kieslinger, A Swoboda, N Kramer, P Freund, B Pratscher, HA Neubauer, R Steinborn, B Wolfesberer, A Fuchs-Baumgartinger, R Moriggl, IA Burener

Cancers (MDPI) Austria, 19 October 2021

Oncology

Key words: STAT5B, driver mutation, feline alimentary lymphoma, STAT3 [more]

Hippocampal and thalamic afferents form distinct synaptic microcircuits in the mouse infralimbic frontal cortex

K Graham, N Spruston, EB Bloss

Cell Reports (Cell Press) USA, 19 October 2021

Neuroscience

Key words: Frontal Cortex, circuit, Synapse, Interneuron, Projection neuron, rabies tracing, hippocampus, thalamus [more]

Autophagy Upregulates miR-449a Expression to Suppress Progression of Colorectal Cancer

SH Lan, SC Lin, WC Wang, YC Yang, JC Lee, PW Lin, ML Chu, KY Lan, R Zuchini, HS Liu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, 19 October 2021

Oncology

Key words: autophagy, miR-449a, FoxO1, colorectal cancer, tumorigenesis [more]

Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis

F Klemm, A Möckl, A Salamero-Boix, T Alekseeva, A Schäffer, M Schulz, K Niesel, RR Maas, M Groth, BT Elie, RL Bowman, ME Hegi, RT Daniel, PS Zeiner, J Zinke, PN Harter, KH Plate, JA Joyce, L Sevenich

Nature Cancer (Nature) Switzerland, Germany, USA, 18 October 2021

Oncology

Key words: Cancer, Cancer microenvironment, Cancer therapeutic resistance, Metastasis [more]

Recent progress in cytometric technologies and their applications in ecotoxicology and environmental risk assessment

D Wlodkowic, A Czerw, B Karakiewicz, A Deptala

Cytometry Part A (Wiley) Australia, Poland, 15 October 2021

Toxicology

An Integrated Bile Acids Profile Determination by UHPLC-MS/MS to Identify the Effect of Bile Acids Supplement in High Plant Protein Diet on Common Carp (Cyprinus carpio)

X Wei, T Yao, FN Fall, M Xue, X Liang, J Wang, W Du, X Gu

Foods (MDPI) China, 15 October 2021

Gastroenterology

Key words: Bile Acids, Common Carp, High Plant Protein Diet, Hepatopancreas, Glycogen Accumulation, UHPLC-MS/MS [more]

Siglec-15 Is an Immune Suppressor and Potential Target for Immunotherapy in the Pre-Metastatic Lymph Node of Colorectal Cancer

H Du, J Tang, X Li, X Wang, L Wu, R Zhang, P Hu, Y Yang

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 13 October 2021

Oncology

Key words: Pre-Metastatic Niche, Lymph Nodes, Colorectal Cancer, Immunosuppressive, SIGLEC15 [more]

LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure

CT Su, TM Jao, Z Urban, YJ Huang, DHW See, YC Tsai, WC Lin, JW Huang

Cell Death & Disease (Nature) Taiwan, 13 October 2021

Nephrology

Key words: Cell signalling, Pathogenesis [more]

Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation

J Strobl, LM Gail, L Kleissl, RV Pandey, V Smejkal, J Huber, V Puxkandl, L Unterluggauer, R Dindelmaier-Hovorka, D Atzmüller, T Krausgruber, C Bock, P Wohlfarth, W Rabitsch, G Stary

Journal of Experimental Medicine (Rockefeller University Press) Austria, 13 October 2021

Immunology

[more]

Sexual dimorphism in the bed nucleus of the stria terminalis, medial preoptic area and suprachiasmatic nucleus in male and female tree shrews

RJ Ni, YM Shu, PH Luo, JN Zhou

Journal of Anatomy (Wiley) China, 12 October 2021

Reproductive Medicine

[more]

Changes in expressions of spermatogenic marker genes and spermatogenic cell population caused by stress

P Tian, Z Zhao, Y Fan, N Cui, B Shi, G Hao

Frontiers in Endocrinology (Frontiers Media S.A.) China, 11 October 2021

Reproductive Medicine

Key words: Stress, Testis, Spermatogenesis, Gene, RNA Sequencing [more]

Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs

L Johnson Chacko, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudas, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fischer, A Zine

International Journal of Molecular Sciences (MDPI) USA, France, UK, Canada, 07 October 2021

Genetics

Key words: Human Induced Pluripotent Stem Cells, Otic Sensory Progenitors, Gene Expression Analysis, Extracellular Matrix, Integrins, Human Fetal Inner Ear [more]

Glucose/Glutathione Co-triggered Tumor Hypoxia Relief and Chemodynamic Therapy to Enhance Photothermal Therapy in Bladder Cancer

WH Chen, KJ Yu, JW Jhou, HH Pang, WH Wenig, WS Lin, HW Yang

ACS Applied Bio Materials (ACS Publications) Taiwan, 07 October 2021

Oncology, Pharmacology

Key words: Photothermal Therapy, Chemodynamic Therapy, Manganese Dioxide (MnO2), Tumor Hypoxia, Bladder Cancer [more]

Irreversible depletion of intestinal CD4+ T-cells is associated with T-cell activation during chronic HIV infection

OE Asowata, A Singh, A Ngoepe, N Herbert, R Faradoos, K Reddy, Y Zuingu, F Nene, N Mthabela, D Ramjit, K Govender, T Ndung'u, JZ Porterfield, JH Adamson, FG Madela, VT Manzini, F Anderson, A Leslie, HN Kløverpris

JCI Insight (American Society of Clinical Investigation) South Africa, Denmark, UK, Germany, USA, 07 October 2021

Immunology, Virology

[more]

Characterizing the host response to rhPDGF‐BB in a rat spinal arthrodesis model

JT Yamaguchi, JA Weiner, S Minardi, AC Greene, DJ Ellenbogen, MJ Hallman, VP Shah, KM Weisz, S Jeong, T Nandurkar, C Yun, WK Hsu, EL Hsu

JOR Spine (Wiley) USA, 07 October 2021

Osteology

[more]

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

B Wang, L Wang, NS Gasek, Y Zhou, T Kim, C Guo, ER Jellison, L Haynes, S Yadav, T Tchkonia, GA Kuchei, JL Kirkland, M Xu

Nature Aging (Nature) USA, China, 07 October 2021

Aging

Key words: Ageing, Animal biotechnology, Senescence

Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

H He, Q Liao, C Zhao, C Zhu, M Feng, Z Liu, L Jiang, L Zhang, X Ding, M Yuan, X Zhang, J Xu

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 06 October 2021

Oncology

[more]

Landscape of prognostic signatures and immunogenomics of the AXL/GAS6 axis in renal cell carcinoma

K Hakozaki, N Tanaka, K Takamatsu, R Takashi, Y Yasumizu, S Mikami, T Shinojima, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, R Mizuno, M Oya

British Journal of Cancer (Nature) Japan, 05 October 2021

Oncology

Key words: Renal Cell Carcinoma, Tumour Biomarkers [more]

NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression

J Liang, W Sun, H Song, C Wang, Q Li, C Li, D Wie, Y Zhao, C Li, H Zhang

Epigenomics (Future Medicine) China, 05 October 2021

Oncology, Pharmacology

Key words: Epithelial–Mesenchymal Transition, NOL6, Nucleolar Protein, Tumorigenesis, TWIST1 [more]

Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis

NS Dey, S Senaratne, V Somaratne, NP Madarasinghe, B Seneviratne, S Forrester, M Montes de Oca, L Capos Reis, S Moulik, PB Walrad, M Chatterjee, H Goto, R Wickremasinghe, D Lagos, PM Kaye, S Ranasinghe

The Journal of Clinical Investigation (American Society of Clinical Investigation) UK, Sri Lanka, Brazil, India, 05 October 2021

Immunology, Parasitology

Key words: Immunology, Infectious Disease [more]

Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model

MK Chiang, PY Hsiao, YY Liu, HL Tang, CS Chiou, MC Lu, YC Lai

Gut Microbes (Taylor & Francis) Taiwan, 04 October 2021

Oncology, Microbiology

Key words: Klebsiella Pneumoniae, ST11, Colorectal Tumorigenesis, IL-10, M2 Macrophages [more]

Epstein-Barr Virus Promotes Tumor Angiogenesis by Activating STIM1-Dependent Ca2+ Signaling in Nasopharyngeal Carcinoma

J Ye, J Wei, Y Luo, Y Deng, T Que, X Zhang, F Liu, J Zhang, X Luo

Pathogens (MDPI) China, 03 October 2021

Oncology, Virology

Key words: Epstein-Barr Virus, Stromal Interaction Molecule 1, Tumor Angiogenesis, Nasopharyngeal Carcinoma [more]

Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer

LE Sima, S Chen, H Cardenas, G Zhao, Y Wang, C Ivan, H Huang, B Zhang, D Matei

Journal for ImmunoTherapy of Cancer (BMJ Journals) USA, Romania, 30 September 2021

Oncology

[more]

Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer's Disease in nonhuman primates

F Yue, S Feng, C Lu, T Zhang, G Tao, J Liu, C Yue, N Jing

iScience (Cell Press) China, 30 September 2021

Neuroscience

Key words: Alzheimer's Disease, Non-Human Primate, Aβ Oligomers, Aβ Plaques, Tau Tangles, Animal Model [more]

Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice

MMT Islam, D Tarnowski, M Zhang, M Trum, S Lebek, J Mustroph, H Daniel, J Moellencamp, S Pabel, S Sossalla, A El-Armouche, VO Nikolaev, AM Shah, P Eaton, LS Maier, CM Sag, S Wagner

Journal of the American Heart Association (AHA Journals) Germany, Bangladesh, UK, 29 September 2021

Cardiology

Key words: Pressure Overload, Redox, Protein Kinase A, Heart Failure [more]

Turning up the heat on non-immunoreactive tumors: pyroptosis influences the tumor immune microenvironment in bladder cancer

X Chen, H Chen, H Yao, K Zhao, Y Zhang, D He, Y Zhu, Y Cheng, R Liu, R Xu, K Cao

Oncogene (Nature) China, Sweden, 29 September 2021

Oncology

Key words: Cancer Microenvironment, Cell Death and Immune Response, Predictive Markers [more]

Adaptive metabolic responses in a thermostabilized environment: Transgenerational trade-off implications from tropical tilapia

MC Wang, MT Hsu, CC Lin, SC Hsu, RD Chen, JR Lee, YL Chou, HP Tseng, F Furukawa, SPL Hwang, PP Hwang, YC Tseng

Science of The Total Environment (Elsevier) Taiwan, Japan, 29 September 2021

Genetics, Ecology

Key words: Thermal Variance, Cold Exposure, Transgenerational Plasticity, Metabolism, Tropical Fish [more]

Human Milk Oligosaccharides alleviate stress-induced visceral hypersensitivity and associated microbiota dysbiosis

L Ferrier, H Eutamène, L Siegwald, AM Marquard, V Tondereau, J Chevalier, GE Jacot, L Favre, V Theodorou, M Vicario, A Rytz, G Bergonzelli, CL Garcia-Rodenas

The Journal of Nutritional Biochemistry (Elsevier) Switzerland, France, Denmark, 25 September 2021

Gastroenterology

Key words: HMOs, Abdominal Pain, Chronic Psychological Stress, Antibiotics, Microbiome, Metagenomic [more]

CD8+ T effector and immune checkpoint signatures predict prognosis and responsiveness to immunotherapy in bladder cancer

X Chen, R Xu, D He, Y Zhang, H Chen, Y Zhu, Y Cheng, R Liu, R Zhu, L Gong, M Xiao, Z Wang, L Deng, K Cao

Oncogene (Nature) China, 22 September 2021

Oncology

Key words: Bladder Cancer, Immunotherapy [more]

Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study

HR Jang, M Kim, S Hong, K Lee, MY Park, KE Yang, CJ Lee, J Jeon, KW Lee, JE Lee, JB Park, K Kim, GY Kwon, YG Kim, DJ Kim, W Huh

Scientific Reports (Nature) South Korea, 22 September 2021

Nephrology

Key words: Biomarkers, Kidney Diseases, Predictive Markers, Renal Replacement Therapy [more]

Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

P Talarska, M Boruczkowski, J Żurawski

Nanomaterials (MDPI) Poland, 21 September 2021

Nanomedicine

Key words: Silver Nanoparticles, Gold Nanoparticles, Nanotoxicology, Nanoparticle Interactions, Nanoparticle Applications [more]

Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy

K Takamatsu, N Tanaka, K Hakozaki, R Takahashi, Y Teranishi, T Murakami, R Kufukihara, N Niwa, S Mikami, T Shinojima, T Sasaki, Y Sato, H Kume, S Ogawa, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, K Sawada, T Imamura, R Mizuno, M Oya

Nature Communications (Nature) Japan, 20 September 2021

Oncology

Key words: Cancer Immunotherapy, Cancer Microenvironment, Predictive Markers, Renal Cell Carcinoma, Tumour Biomarkers [more]

PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression

XY Qin, QH Shan, H Fang, Y Wang, P Chen, ZQ Xiong, DF Swaab, JN Zhou

Acta Neuropathologica (Springer) China, The Netherlands, 18 September 2021

Neuroscience

Key words: Depression, Paraventricular Nucleus, PSD-93, Corticotropin-Releasing Hormone, Synaptic Regulation [more]

Interferon Gamma-Induced Interferon Regulatory Factor 1 Activates Transcription of HHLA2 and Induces Immune Escape of Hepatocellular Carcinoma Cells

R Wang, H Guo, X Tang, T Zhang, Y Liu, C Zhang, H Yu, Y Li

Inflammation (Springer) China, 18 September 2021

Oncology, Immunology

Key words: Hepatocellular Carcinoma, HHLA2, Tumor-Associated Macrophages, PD-L1, Immune Escape, IFNG, IFR1 [more]

Experimental nerve transfer model in the neonatal rat

ME Sporer, M Aman, KD Bergmeister, D Depisch, KM Scheuba, E Unger, BK Podesser, OC Aszmann

Neural Regeneration Research (Wolters Kluwer) Austria, 17 September 2021

Regenerative Medicine, Neuroscience

Key words: brachial plexus birth injury, experimental rat model, extremity reconstruction, methodological paper, neonatal rat, nerve reconstruction, nerve regeneration, nerve transfer, neural plasticity, peripheral nerve surgery [more]

Multiomic analysis reveals comprehensive tumor heterogeneity and distinct immune subtypes in multifocal intrahepatic cholangiocarcinoma

SL Chen, Y Xie, Y Cai, H Hu, M He, L Liu, C Liao, Y Wang, J Wang, X Ren, Q Zeng, H Peng, S Shen, SQ Li, D Li, J Lai, B Peng, J Ren, M Kuang, S Peng

Clinical Cancer Research (AACR Publications) China, 15 September 2021

Oncology

Key words: Multifocal Intrahepatic Cholangiocarcinoma, Heterogeneity, Clonal Evolution, Immune Microenvironment, Immunotherapy [more]

Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress

BG Durgin, KC Wood, SA Hahn, B McMahon, JJ Baust, AC Straub

Journal of Molecular and Cellular Cardiology (Elsevier) USA, 15 September 2021

Cardiology

Key words: Smooth Muscle Cell, Redox, Hypoxia, Nitric Oxide, Hypertrophy, Soluble Guanylyl Cyclase [more]

LncRNA PVT1 knockdown ameliorates myocardial ischemia reperfusion damage via suppressing gasdermin D-mediated pyroptosis in cardiomyocytes

C Li, H Song, C Chen, S Chen, Q Zhang, D Liu, J Li, H Dong, Y Wu, Y Liu

Frontiers in Cardiovascular Medicine (Frontiers Media S.A.) China, 14 September 2021

Cardiology

Key words: lncRNA, PVT1, Myocardial Ischemia Reperfusion, Pyroptosis, Gasdermin D [more]

Estimating the time of skeletal muscle contusion based on the spatial distribution of neutrophils: a practical approach to forensic problems

Q Du, L Wang, D Li, J Niu, X Zhang, J Sun

International Journal of Legal Medicine (Springer) China, 13 September 2021

Biological Methods

Key words: Estimating Injury Time, Spatial Distribution, Immunohistochemical, Skeletal Muscle Contusion, Fisher Discriminant Analysis [more]

Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against …

Y Ni, BC Hu, GH Wu, ZQ Shao, Y Zheng, R Zhang, J Jin, J Hong, XH Yang, RH Sun, JQ Liu, SJ Mo

Theranostics (Ivyspring International Publisher) China, 13 September 2021

Immunology

Key words: Neutrophil extracellular traps, Fibroblast growth factor-inducible molecule 14, Macrophages, Homeobox protein Hox-A5, Septic acute kidney injury [more]

N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation

J Li, X Hu, T Luo, Y Lu, Y Feng, H Zhang, D Liu, X Fan, Y Wang, L Jiang, Y Wang, X Hao, T Shi, Z Wang

European Journal of Medicinal Chemistry (Elsevier) China, 10 September 2021

Biological Materials

Key words: Glioma, N-2-(Phenylamino) Benzamide, Topoisomerase I Inhibitor, COX-2 Inhibitor, Pseudocycle [more]

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

S Niu, W Shi, Y Li, S Yi, Y Li, X Liu, B Cong, G He

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 08 September 2021

Neuroscience

[more]

Case Study of Noni Extract in Men with Very Low-Risk or Low-Risk Prostate Cancer

Y Hirasawa, I Pagano, JH Pharm, Y Sasaki, K Murakami, CJ Rosser, H Furuya

Hawai 'i Journal of Health & Social Welfare (hawaiijournalhealth.org) USA, 08 September 2021

Oncology

Key words: Prostate Cancer, Active Surveillance, Noni [more]

Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile

H Rossiter, D Copic, M Direder, F Gruber, S Zoratto, M Marchetti-Deschmann, C Kremslehner, M Sochorova, IM Nagelreiter, V Mlitz, M Buchberger, B Lengauer, B Golabi, S Sukseree, M Mildner, L Eckhart, E Tschachler

Autophagy (Taylor & Francis) Austria, 07 September 2021

Aging

Key words: Autophagosomes, GFP-LC3, Lipid Droplets, Perilipin, Sebocytes [more]

Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia

DR Collins, JM Urbach, ZJ Racenet, U Arshad, KA Power, RM Newman, GH Mylvaganam, NL Ly, X Lian, A Rull, Y Rassadkina, AG Yanez, MJ Peluso, SG Deeks, F Vidal, M Lichterfeld, XG Yu, GD Gaiha, TM Allen, BD Walker

Immunity (Cell Press) USA, Spain, 07 September 2021

Virology, Immunology

Key words: Human Immunology, HIV Control, CD8+ T Cell Dysfunction [more]

Reciprocal regulation of endothelial–mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease

B Vanchin, M Sol, RAF Gjaltema, M Brinker, B Kiers, AC Pereira, MC Harmsen, JAJ Moonen, G Krenning

Scientific Reports (Nature) The Netherlands, Mongolia, Brazil, 07 September 2021

Cardiology

Key words: Cell Signalling, Epigenetics, Mechanisms of Disease, Non-Coding Rnas, Pathogenesis, Vascular Diseases [more]

PAC1 receptor mediates electroacupuncture-induced neuro and immune protection during cisplatin chemotherapy

S Li, J Huang, Y Guo, J Wang, S Lu, B Wang, Y Gong, S Qin, S Zhao, S Wang, Y Liu, Y Fang, Y Guo, Z Xu, L Ulloa

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 06 September 2021

Oncology, Pharmacology

Key words: Neuromodulation, Chemotherapy, Immunosuppression, Hematopoiesis, Neurotoxic, Electroacupuncture [more]

Elevated β-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease

L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen

Brain, Behavior, and Immunity (Elsevier) China, 06 September 2021

Neuroscience

Key words: β -Secretase, CD4+ T Cell, PGE2 Signalling, Alzheimer's Disease, Neuroinflammation, T Cell Receptor (TCR) [more]

Single‐cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer

H Lai, X Cheng, Q Liu, W Luo, M Liu, M Zhang, J Miao, Z Ji, GN Lin, W Song, L Zhang, J Bo, G Yang, J Wang, WQ Gao

International Journal of Cancer (Wiley) China, 03 September 2021

Oncology

[more]

Decompartmentalisation as a simple color manipulation of plant-based marbling meat alternatives

S Ong, L Loo, M Pang, R Tan, Y Teng, X Lou, SK Chin,MY Naik, H Yu

Biomaterials (Elsevier) Singapore, 03 September 2021

Biological Materials, Tissue Engineering

Key words: Cell-Based Meat, Edible Scaffold, Meat Marbling, Cellulose, Polyphenol, Organoleptic [more]

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas

C Gribben, C Lambert, HA Messal, EL Hubber, C Rackham, I Evans, H Heimberg, P Jones, R Sancho, A Behrens

Cell Stem Cell (Cell Press) UK, Belgium, Germany, 02 September 2021

Stem Cell Research

Key words: β Cells, Pancreas, Diabetes, δ Cells, Lineage Tracing, Ngn3, Progenitor, Regeneration [more]

Nanostructured Lipid Carrier Gel Formulation of Recombinant Human Thrombomodulin Improve Diabetic Wound Healing by Topical Administration

YS Hsueh, YJ Shyong, HC Yu, SJ Jheng, SW Lin, HL Wu, JC Tsai

Pharmaceutics (MDPI) Taiwan, 02 September 2021

Biological Materials

Key words: Nanostructured Lipid Carrier, Protein Drug Delivery, Sustained Release, Chronic Wound Healing, Angiogenesis Factor, Carbopol Gel, Thrombomodulin [more]

A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution

H Yang, S Yang, F Fan, Y Li, S Dai, X Zhou, CC Steiner, B Coppedge, C Roos, X Cai, DM Irwin, P Shi

Molecular Biology and Evolution (Oxford Academic) China, USA, Germany, Canada, 01 September 2021

Genetics, Evolution

Key words: Convergent Evolution, Bitter Taste Receptors, Tas2R16, Human, White-Faced Saki, Pithecia Pithecia, Adaptive Evolution [more]

Improving Mask R-CNN for Nuclei Instance Segmentation in Hematoxylin & Eosin-Stained Histological Images

B Bancher, A Mahbod, I Ellinger, R Ecker, G Dorffner

Proceedings of Machine Learning Research (PMLR) Austria, 01 September 2021

Machine Learning

Key words: Mask R-CNN, Nuclei Segmentation, Medical Image Analysis, Deep Learning, Computational Pathology

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation

M Rath, A Pitiot, M Kirr, W Fröhlich, B Plosnita, S Schliep, J Bauerschmitz, AS Baur, C Ostalecki

International Journal of Molecular Sciences (MDPI) Germany, UK, Austria, 30 August 2021

Dermatology

Key words: Scar, Dendritic Cells, Tumor Microenvironment, Single-Cell Analysis, Multiplex Imaging, Proteases, Tumor Biology [more]

Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury

WZ Wang, X Liu, ZY Yang, YZ Wang, HT Lu

Neural Regeneration Research (Wolters Kluwer) China, 30 August 2021

Neuroscience

Key words: brain-derived neurotrophic factor, diffusion tensor imaging, fractional anisotropy value, global cerebral ischemia/reperfusion injury, hippocampus, TrkB [more]

Characteristics of Chlamydia suis Ocular Infection in Pigs

C Unterweger, A Inic-Kanada, S Setudeh, C Knecht, S Duerlinger, M Stas, D Vanrompay, C Kiekens, R Steinparzer, W Gerner, A Ladinig, T Barisani-Asenbauer

Pathogens (MDPI) Austria, Belgium, 29 August 2021

Microbiology

Key words: Chlamydia Suis, Piglets, Experimental Conjunctival Infection, Serology, Antibodies, Immunohistochemistry, Lacrimal Gland [more]

Bone Marrow Remodelling Supports Hematopoiesis in Response to Immune Thrombocytopenia Progression in Mice

OJ Herd, GF Rani, JP Hewitson, K Hogg, AP Stone, N Cooper, DG Kent, PG Genever, IS Hitchcock

Blood Advances (Elsevier) UK, 26 August 2021

Hematology

[more]

TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas

E Gonzalez-Buendia, J Zhao, L Wang, S Mukherjee, D Zhang, VA Arrieta, E Feldstein, JR Kane, SJ Kang, C Lee-Chang, A Mahajan, L Chen, R Realubit, C Karan, L Magnuson, C Horbinski, SA Marshall, JN Sarkaria, A Mohyeldin, I Nakano, M Bansal, CD James, DJ Brat, A Ahmed, P Canoll, R Rabadan, A Shilatifard, AM Sonabend

Clinical Cancer Research (AACR Publications) USA, 25 August 2021

Oncology

[more]

Biocompatible Copper Sulfide Based Nanocomposites for Artery Interventional Chemo-Photothermal Therapy of Orthotropic Hepatocellular Carcinoma

X Li, H Yuan, X Tian, J Tang, L Liu, F Liu

Materials Today Bio (Elsevier) China, 25 August 2021

Nanomedicine

Key words: DOX@BSA-CuS Nanocomposites, NIR-Responsive, Photothermal Ablation, Chemoembolization, MRI Guided Therapy [more]

Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin

R Herzog, JM Sacnun, G González-Mateo, M Bartosova, K Bialas, A Wagner, M Unterwurzacher, IJ Sobieszek, L Daniel-Fischer, K Rusai, L Pascual-Antón, K Kaczirek, A Vychytil, C Peter Schmitt, M López-Cabrera, SL Alper, C Aufricht, K Kratochwill

Science Translational Medicine (AAAS) Austria, Spain, Germany, USA, 25 August 2021

Nephrology

[more]

Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma

TH Hung, JT Hung, CE Wu, Y Huang, CW Lee, CT Yeh, YH Chung, FY Lo, LC Lai, JK Tung, J Yu, CN Yeh, AL Yu

Hepatology Communications (Wiley) Taiwan, 24 August 2021

Hepathology, Oncology

[more]

Oroxylin A promotes therapeutic efficacy of cisplatin to suppress bladder cancer progression via inducing ferroptosis

Q Tang, J Jiang, J Sun, L Tang, X Zhang

Biochemical and Biophysical Research Communications (Elsevier) China, 21 August 2021

Oncology, Pharmacology

Key words: Bladder Cancer, cDDP, Oroxylin A (OroA), Ferroptosis [more]

Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity

V Azzimato, P Chen, E Barreby, C Morgantini, L Levi, A Vankova, J Jager, A Sulen, M Diotallevi, JX Shen, A Miller, E Ellis, M Rydén, E Näslund, A Thorell, VM Lauschke, KM Channon, MJ Crabtree, A Haschemi, Sm Craige, M Mori, F Spallotta, M Aouadi

Gastroenterology (Elsevier) Sweden, France, UK, Austria, Germany, USA, Italy, 21 August 2021

Gastroenterology

Key words: Liver, Metabolism, Oxidative Stress, miRNAs, Fumarase [more]

Spatially Resolved Immunometabolism to Understand Infectious Disease Progression

R Tans, S Dey, NS Dey, G Calder, P O'Toole, PM Kaye, RMA Heeren

Frontiers in Microbiology (Frontiers Media S.A.) The Netherlands, UK, 19 August 2021

Immunology

Key words: Immunometabolism, Infectious Disease, Inflammation, Granulomas, Mass Spectrometry Imaging, Spatial Transcriptomics, Multi-Omics, Leishmaniasis

Maternal Immune Activation Causes Social Behavior Deficits and Hypomyelination in Male Rat Offspring with an Autism-Like Microbiota Profile

GA Lee, YK Lin, JH Lai, YC Lo, YCSH Yang, SY Ye, CJ Lee, CC Wang, YH Chiang, SH Tseng

Brain Sciences (MDPI) Taiwan, 18 August 2021

Neuroscience

Key words: Autism Spectrum Disorder, Lipopolysaccharide, Maternal Immune Activation, Microbiota, Three-Chamber Test, Myelination, Brain–Gut–Microbiota Axis, Social Behavior Deficits [more]

Effects of Vitamin D-Deficient Diet on Intestinal Epithelial Integrity and Zonulin Expression in a C57BL/6 Mouse Model

CY Yeung, JSC Chiau, ML Cheng, WT Chan, CB Jiang, SW Chang, CY Liu, CW Chang, HC Lee

Frontiers in Medicine (Frontiers Media S.A.) Taiwan, 16 August 2021

Gastroenterology

Key words: Vitamin D, Gut Integrity, Tight Junction, Zonulin, Leaky Gut [more]

A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge

X He, L Ding, K Cao, H Peng, C Gu, Y Li, D Li, L Dong, X Hong, X Wang, M Fu, C Qiu, C Zhu, Z Zhang, S Song, C Wang, Z Jiang, Y Xie, Z Qi, C Zhao, P Zhao, X Zhang, J Xu

Emerging Microbes & Infections (Taylor & Francis) China, 12 August 2021

SARS-CoV-2

Key words: SARS-CoV-2, Cell-Based Vaccines, K562-S, Mouse Model, Non-Human Primate Model, Neutralizing Antibody, Protection [more]

Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus

D Douchi, A Yamamura, J Matsuo, YHM Lim, N Nuttonmanit, M Shimura, K Suda, S Chen, S Pang, K Kohu, T Abe, G Shioi, G Kim, A Shabbir, S Srivastava, M Unno, JBY So, M Teh, KG Yeoh, LSH Chuang, Y Ito

Gastroenterology (Elsevier) Singapore, Japan, 12 August 2021

Gastroenterology

Key words: Metaplasia, Intramucosal Dysplasia, Invasive and Metastatic Gastric Cancer, Gastric Carcinogenesis, Mouse Model [more]

Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells

L Kappert, P Ruzicka, A Kutikhin, C De La Torre, A Fischer, M Hecker, C Arnold, T Korff

The FASEB Journal (Wiley) Germany, Russia, 12 August 2021

Cardiology

[more]

The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells

PJ Kung, TY Lai, J Cao, LC Hsu, TC Chiang, P Ou-Yang, CY Tsai, YF Tsai, CW Lin, CC Chen, MK Tsai, YW Tien, CY Lee

Cancer Immunology, Immunotherpay (Springer) Taiwan, Australia, 10 August 2021

Oncology, Immunology

Key words: S100A9, PD-L1, Pancreatic Ductal Adenocarcinoma, PSC [more]

Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer

E Shrestha, JB Coulter, W Guzman, B Ozbek, MM Hess, L Mummert, SE Ernst, JP Maynard, AK Meeker, CM Heaphy, MC Haffner, AM De Marzo, KS Sfanos

PNAS (United States National Academy of Sciences) USA, 10 August 2021

Oncology

Key words: Prostate Cancer, Infection, Inflammation, TMPRSS2:ERG Fusion, Colibactin [more]

Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultraviolet Light–Induced Pterygium

CC Lai, SH Tseng, SM Hsu, YT Huang, CC Shieh

Investigative Ophthalmology & Visual Science (ARVO Journals) Taiwan, 09 August 2021

Ophthalmology

Key words: Pterygium, Pterygial Epithelial Cells, Toll-Like Receptor 3, Ultraviolet B, NF-κB [more]

Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer

SC Wang, YC Chang, MY Wu, CY Yu, SL Chen, WW Sung

Cancers (MDPI) Taiwan, 04 August 2021

Oncology

Key words: Bladder Cancer, Azacitidine, Intravesical Instillation, TNF-R1, TRAIL-R2 [more]

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

LC Russo, R Tomasin, IA Matos, AC Manucci, ST Sowa, K Dale, KW Caldecott, L Lehtiö, D Schechtman, FC Meotti, A Bruni-Cardoso, NC Hoch

Journal of Biological Chemistry (ASBMB) Brazil, Finland, UK, 04 August 2021

SARS-CoV-2, Immunology

Key words: COVID-19, SARS-CoV-2, ADP-ribosylation, PARP9, DTX3L, macrodomain [more]

Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway

X Wu, Z Wang, Y Jiang, H Zhou, A Li, Y Wie, Z Bao, D Wang, J Zhao, X Chen, Y Guo, Z Dong, K Liu

Frontiers in Oncology (Frontiers Media S.A.) China, 04 August 2021

Oncology

Key words: Esophageal Squamous Cell Carcinoma, Tegaserod Maleate, Proteome, Peroxisome, Peroxisome Membrane Protein 11B, Peroxisome Membrane Protein 13, Patient-Derived Xenograft [more]