Customer Publications (A total of 3040 papers published)
Characterization of genetic humanized mice with transgenic HLA DP401 or DRA but deficient in endogenous murine MHC class II genes upon Staphylococcus aureus pneumonia
Animal Models and Experimental Medicine (Wiley) China, 23 May 2023
Pathology
Organism: Mouse
Tissue: Lung, Lymphoid Tissue
Pathological State: Bacterial Infection
Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats
Biology (MDPI) China, 23 May 2023
Neuroscience, Aging
Key words: aromatase, brain-derived estrogen, neurogenesis, gliogenesis, aging [more]
Organism: Rat
Tissue: Brain
M2e‐specific antibodies protect against influenza PR8 virus in an isotype and route dependent manner
Journal of Medical Virology (Wiley) China, 23 May 2023
Immunology, Virology
Key words: Antibody, influenza A virus, isotype, M2e, protection [more]
Organism: Mouse
Tissue: Lung
Pathological State: Influenza PR8 Infection
Identification of cervical cancer stem cells using single-cell transcriptomes of normal cervix, cervical premalignant lesions, and cervical cancer
eBioMedicine (Elsevier) China, 22 May 2023
Stem Cell Research, Oncology
Key words: Cervical cancer, Single-cell RNA sequencing, HSIL, Microinvasive carcinoma of the cervix, Cancer stem cell, Tumor microenvironment [more]
Organism: Human
Tissue: Cervix
Pathological State: Cancer
The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage
Journal of Neuroinflammation (Springer) China, 22 May 2023
Ophthalmology
Key words: Retinal degeneration, BET, Neuroinflammation, PROTAC, cGAS-STING, Microglia/macrophage [more]
Organism: Mouse
Tissue: Eye
Enhancing de novo ceramide synthesis induced by bisphenol A exposure aggravates metabolic derangement during obesity
Molecular Metabolism (Elsevier) China, UK, 22 May 2023
Endocrinology
Key words: Bisphenol A, ceramide, adipose tissue inflammation, insulin resistance, myriocin [more]
Organism: Mouse
Tissue: Adipose Tissue
Pathological State: Obesity
APP/PS1 Gene-Environmental Cadmium Interaction Aggravates the Progression of Alzheimer's Disease in Mice via the Blood-Brain Barrier, Amyloid-β, and Inflammation
Journal of Alzheimer's Disease (IOS Press) China, 20 May 2023
Neuroscience
Key words: Alzheimer’s disease, APP/PS1 gene, blood-brain barrier, cadmium, gene-environment interaction, inflammatory response
Increased number and domain of interlaminar astrocytes in layer I of the temporal cortex in epilepsy
Neuropathology and Applied Neurobiology (Wiley) China, 20 May 2023
Neuroscience
Key words: Interlaminar astrocytes, Chaslin’s gliosis, Astrocyte domain, Temporal cortex, Epilepsy [more]
Organism: Human
Tissue: Brain
Pathological State: Epilepsy
NLRP3‐Dependent Crosstalk between Pyroptotic Macrophage and Senescent Cell Orchestrates Trauma‐Induced Heterotopic Ossification During Aberrant Wound Healing
Advanced Science (Wiley) China, 19 May 2023
Osteology
Organism: Mouse
Tissue: Muscle, Bone
Targeting CD44 variant 5 with an antibody-drug conjugate is an effective therapeutic strategy for intrahepatic cholangiocarcinoma
Cancer Research (AACR) China, Ireland, 19 May 2023
Pharmacology, Oncology
Key words: intrahepatic cholangiocarcinoma, CD44 variant 5, antibody-drug conjugate, PDX [more]
Organism: Human
Tissue: Bile duct
Pathological State: Cancer
Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression-and anxiety-like behavior in mice
Ecotoxicology and Environmental Safety (Elsevier) China, 19 May 2023
Neuroscience, Toxicology
Key words: Bisphenol A (BPA), Depression- and anxiety-like behavior, Microglial activation, Neuroinflammation, Medial prefrontal cortex (mPFC) [more]
Organism: Mouse
Tissue: Brain
Pathological State: Depression
Cytolytic CD8+ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes
Science Immunology (Science) USA, Germany, 19 May 2023
Immunology, Virology
Organism: Human
Tissue: Lymphoid Tissue
Pathological State: HIV Infection
Following nanoparticle uptake by cells using high-throughput microscopy and the deep-learning based cell identification algorithm Cellpose
Frontiers in Nanotechnology (Frontiers Media S.A.) , 18 May 2023
Nanomedicine, Medical Image Analysis
Key words: nanoparticles, cell uptake, fluorescence microscopy, high-throughput, machine learning, image segmentation, modelling, Cellpose [more]
Cell Line: HeLa cells
Peptide-Functionalized and Drug-Loaded Tomato Bushy Stunt Virus Nanoparticles Counteract Tumor Growth in a Mouse Model of Shh-Dependent Medulloblastoma
International Journal of Molecular Sciences (MDPI) Italy, 17 May 2023
Pharmacology, Oncology
Key words: TBSV NPs, drug delivery system, doxorubicin, preclinical study, Ptch1+/− mice, MB therapy [more]
Organism: Mouse
Tissue: Brain
Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma
Cell Reports Medicine (Cell Press) China, 16 May 2023
Immunology, Oncology
Organism: Mouse
Tissue: Liver
Pathological State: Cancer
Short‐term toll‐like receptor 9 inhibition leads to left ventricular wall thinning after myocardial infarction
ESC Heart Failure (Wiley) Austria, 16 May 2023
Pharmacology, Cardiology
Key words: CXCR2, Infarction, Ischaemia–reperfusion, Neutrophils, TLR9 [more]
Organism: Rat
Tissue: Heart
Pathological State: Ischaemia–reperfusion injury
Effects of Therapeutic Hypothermia on Macrophages in Mouse Cochlea Explants
International Journal of Molecular Sciences (MDPI) Austria, 16 May 2023
Otolaryngology
Key words: cochlea implant, IBA1, F4/80, CD163, CD45, immune response, inner ear, hypothermia [more]
Organism: Mouse
Tissue: Ear
High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway
American Journal of Cancer Research (e-Century Publishing) China, 15 May 2023
Oncology
Key words: Peroxisomal D-bifunctional protein, hepatocellular carcinoma, HepG2, apoptosis, energy metabolism, PI3K/AKT pathway [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-κB signaling pathway activation in aged mice
Inflammation Research (Springer) China, 15 May 2023
Aging
Key words: Microglia, Neuroinflammation, Postoperative cognitive dysfunction, Fluoxetine, Toll-like receptor 4 [more]
Organism: Mouse
Tissue: Brain
Characterization of Early and Late Damage in a Mouse Model of Pelvic Radiation Disease
International Journal of Molecular Sciences (MDPI) Italy, 15 May 2023
Radiotherapy
Key words: mouse model, intestinal damage, ionizing radiation, intestinal stem cells, fecal markers [more]
Organism: Mouse
Tissue: Colon
Pathological State: Pelvic Radiation Disease
Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice
Cell Death & Disease (Nature) China, 12 May 2023
Stem Cell Research
Key words: Mesenchymal stem cells, Stem-cell research [more]
Organism: Mouse
Tissue: Muscle
Pathological State: Sarcopenia
Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity
Environmental Pollution (Elsevier) China, 12 May 2023
Gastroenterology
Key words: Nanoplastics, Intestinal barrier, Tight junction protein, Mucin2, IL-10 [more]
Organism: Mouse
Tissue: Small Intestine
Inactivation of EGFR/ERK/NF‐κB signalling associates with radiosensitizing effect of 18β‐glycyrrhetinic acid on progression of hepatocellular carcinoma
Journal of Cellular and Molecular Medicine (Wiley) Taiwan, 12 May 2023
Oncology
Key words: 18β- Glycyrrhetinic acid, epidermal growth factor receptor, ERK, hepatocellular carcinoma, NF-κB, radiotherapy [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Inactivation of EGFR/ERK/NF-? B signalling associates with radiosensitizing effect of 18ß-glycyrrhetinic acid on progression of hepatocellular carcinoma
Journal of Cellular and Molecular Medicine (Wiley) Taiwan, 12 May 2023
Oncology
Key words: 18β- Glycyrrhetinic acid, epidermal growth factor receptor, ERK, hepatocellular carcinoma, NF- κB, radiotherapy [more]
Organism: Mouse
Tissue: Spleen, Heart, Colon, Liver, Kidney
Pathological State: Cancer
Stromal and intratumoral T cell infiltration in head and neck squamous cell carcinoma
Laryngo-Rhino-Otologie (thieme-connect.com) Germany, 12 May 2023
Immunology, Oncology
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study
Frontiers in Cellular Neuroscience (Frontiers Media S.A.) Taiwan, 11 May 2023
Neuroscience
Key words: cerebrospinal fluid, intracerebral hemorrhage (ICH), neurogenesis, subventricular zone (SVZ), brain-derived neurotrophic factor (BDNF) [more]
Organism: Rat
Tissue: Brain
Pathological State: Intracerebral hemorrhage
A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8+ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma
OncoImmunology (Taylor & Francis) Sweden, 10 May 2023
Immunology, Oncology
Key words: Granzyme B, γδ T cells, Immunoscore, Type I Interferon, MxA, Neoadjuvant treatment, Rectal Cancer, Tumor infiltrating lymphocytes [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancer
Oncogene (Nature) USA, 09 May 2023
Oncology
Key words: Cell death, Intermediate filaments, Non-small-cell lung cancer [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss
Research (AAAS) South Korea, 09 May 2023
Neuroscience
Organism: Mouse
Tissue: Muscle
Pathological State: Age-related Motor Neuron Degeneration
Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain
Cell & Bioscience (BMC) China, 05 May 2023
Neuroscience
Key words: Neuregulin 1, Cre-reporting mice, Olfactory bulb, Striatum, Cerebral cortex, Hippocampus, Hypothalamus, cerebellum, axon projection [more]
Organism: Mouse
Tissue: Brain
Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC
Oncogenesis (Nature) China, 05 May 2023
Oncology
Key words: Cancer prevention, Oesophageal cancer, Target identification, Target validation [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis
Journal of Experimental & Clinical Cancer Research (BMC) China, USA, 04 May 2023
Oncology
Key words: Pancreatic cancer, Organoids, High-throughput drug screening, c-Jun, Irbesartan [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance
Nature Cancer (Nature) USA, 04 May 2023
Oncology
Key words: Cancer, Immunosurveillance, Pancreatic cancer, Senescence, Targeted therapies [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Renewal of Oligodendrocyte Lineage Reverses Dysmyelination and CNS Neurodegeneration Through Corrected N-acetylaspartate Metabolism
Progress in Neurobiology (Elsevier) USA, China, Germany, 04 May 2023
Neuroscience
Key words: CNS, Neurodegeneration, Demyelination, Gene therapy, AAV, Canavan disease, N-acetylaspartate, Oligodendrocytes, Neurons [more]
Organism: Mouse
Tissue: Brain
Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer
Science Translational Medicine (Science) USA, 03 May 2023
Immunology, Oncology
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
The ICAM-1 ligand HRV-A89 is internalized independently of clathrin-mediated endocytosis and its capsid reaches late endosomes
Virology (Elsevier) Austria, 03 May 2023
Cell Biology
Key words: Arf6, Chlorpromazine, Endocytosis, ICAM-1, Imipramine, Rhinovirus [more]
Cell Line: HeLa cells
Androgen therapy does not prevent bone loss and arterial calcifications in male rats with chronic kidney disease
Journal of Endocrinology (Society for Endocrinology) Belgium, 02 May 2023
Endocrinology, Hepatology
Key words: androgen replacement therapy, chronic kidney disease, hypogonadism, bone loss, arterial calcification [more]
Organism: Rat
Tissue: Blood Vessels
Pathological State: Kidney disease
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain
Life Science Alliance (Life Science Alliance) The Netherlands, Portugal, Germany, Belgium, USA, 02 May 2023
Neuroscience, Developmental Biology
Organism: Mouse
Tissue: Brain
Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses
Stem Cell Reviews and Reports (Springer) Brazil, 02 May 2023
Immunology, Neuroscience
Key words: Neural progenitor cells, Cytokines, Degenerative disease, Neural development, Neuroinflammation [more]
Organism: Mouse
Cell Line: Neurospheres
Reshaping fish intestinal microbiota and facilitating barrier function by ZnO nanoparticles
Environmental Science: Nano (Royal Society of Chemistry) China, 01 May 2023
Nanomedicine, Zoology
Organism: Fish
Tissue: Colon
Therapeutic efficacy of a MMAE-based anti-DR5 drug conjugate Oba01 in preclinical models of pancreatic cancer
Cell Death & Disease (Nature) China, 29 April 2023
Oncology, Pharmacology
Key words: Preclinical research, Targeted therapies [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Expression-based subtypes define pathologic response to neoadjuvant immune-checkpoint inhibitors in muscle-invasive bladder cancer
Nature Communications (Nature) Canada, USA, Brazil, France, USA, Italy, UK, 27 April 2023
Oncology
Key words: Bladder cancer, Tumour immunology [more]
Organism: Human
Tissue: Bladder
Pathological State: Cancer
Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma
Aging (Impact Journals) Taiwan, 21 April 2023
Pharmacology, Oncology
Key words: melatonin, bladder cancer, apoptosis, NF-κB, HIF-1α [more]
Cell Line: UMUC3 and T24 cells
Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms
Cell Death & Disease (Nature) Brazil, 21 April 2023
Oncology
Key words: Cytoskeleton, DNA damage and repair [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
BiTE‐Secreting CAR‐γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors
Advanced Science (Wiley) Taiwan, 20 April 2023
Oncology, Pharmacology
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Association of Neutrophil Extracellular Traps with Fistula Healing in Patients with Complex Perianal Fistulizing Crohn’s Disease
Journal of Crohn's and Colitis (Oxford Academic) China, 19 April 2023
Gastroenterology
Key words: Perianal fistulising Crohn’s disease; fistula healing; neutrophil extracellular traps. [more]
Organism: Human
Tissue: Colon
Pathological State: Crohn's Dieseas
Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I
Elife (eLife Sciences Publications) USA, 19 April 2023
Immunology, Virology
Cell Line: Macrophages
BushenHuoxue decoction suppresses M1 macrophage polarization and prevents LPS induced inflammatory bone loss by activating AMPK pathway
Heliyon (Cell Press) China, 19 April 2023
Immunology
Key words: Inflammatory bone loss, Bushen huoxue decoction, Inflammation, Macrophage polarization, Bone immune regulation [more]
Organism: Mouse
Tissue: Bone
Targeting YAP1 ameliorates progesterone resistance in endometriosis
Human Reproduction (Oxford Academic) Taiwan, 18 April 2023
Reproductive Medicine
Key words: YAP1, miR-21-5p, PGR, progesterone resistance, endometriosis [more]
Organism: Human
Tissue: Endometrium
Pathological State: Endometriosis
IKKα inhibition re-sensitizes acquired adriamycin-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis
Scientific Reports (Nature) China, 17 April 2023
Oncology, Pharmacology
Key words: Cancer, Chemical biology, Diseases, Genetics [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Adiponectin reverses β‐Cell damage and impaired insulin secretion induced by obesity
Aging Cell (Wiley) Brazil, 14 April 2023
Endocrinology
Key words: adiponectin, calorie restriction, diabetes, obesity, oxidative phosphorylation [more]
Organism: Mouse
Tissue: Pancreas
Pathological State: Obesity
Upregulation of dendrocyte-expressed seven transmembrane protein is associated with unfavorable outcomes in differentiated thyroid cancer
Endocrine (Springer) Taiwan, 14 April 2023
Oncology, Pharmacology
Key words: DCSTAMP, Recurrence, Survival, Thyroid cancer, Immunohistochemistry [more]
Organism: Human
Tissue: Thyroid
Single-cell transcriptome analysis revealed the immune profile of PD-1 blockade in gallbladder carcinoma liver metastasis
Hepatology Communications (Wiley) China, 14 April 2023
Oncology
Organism: Human
Tissue: Gallbladder
Pathological State: Cancer
Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity
Journal of Clinical Medicine (MDPI) Romania, 14 April 2023
Endocrinology, Oncology
Key words: arterial stiffness, adipokines, morbid obesity, cardiovascular risk, perivascular adipose tissue [more]
Organism: Human
Tissue: Adipose Tissue
Pathological State: Obesity
The effects of mild hypothermia on the electrode insertion trauma in a murine whole organ cochlea culture
Frontiers in Neuroscience (Frontiers Media S.A.) Austria, 13 April 2023
Pathology
Key words: hypothermia, whole organ cochlea culture, electrode insertion trauma, cochlear implant, sensorineural hearing loss, hearing rehabilitation [more]
Organism: Mouse
Tissue: Ear
Yellow mealworm (Tenebrio Molitor) enhances intestinal immunity in largemouth bass (Micropterus salmoides) via the NFκB/survivin signaling pathway
Fish & Shellfish Immunology (Elsevier) China, 11 April 2023
Zoology
Key words: Yellow mealworm, Largemouth bass, Intestinal immunity, NFκBp65, Survivin [more]
Organism: Fish
Tissue: Colon
Axonal mapping of motor and sensory components within the ulnar nerve and its branches
Journal of Neurosurgery (American Association of Neurological Surgeons) Austria, 07 April 2023
Neuroscience
Key words: axon count, flexor carpi ulnaris muscle, flexor digitorum profundus muscle, nerve transfer, deep branch of the ulnar nerve, superficial branch of the ulnar nerve, peripheral nerve, anatomy [more]
Organism: Human
Tissue: Nerves
Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia
Blood (ASH Publications) Germany, USA, China, Romania, Austria, Australia, 06 April 2023
Oncology
Key words: chronic lymphocytic leukemia, TCL1A, KDM1A, epigenetics, histone modulation [more]
Organism: Mouse
Tissue: Spleen
Pathological State: Cancer
Neuroprotective effects of resistance physical exercise on the APP/PS1 mouse model of Alzheimer's disease
Frontiers in Neuroscience (Frontiers Media S.A.) Brazil, 06 April 2023
Pharmacology, Neuroscience
Key words: Alzheimer’s disease, resistance exercise, locomotor activity, corticosterone, amyloid-beta precursor protein [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer’s disease
Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis
Nature Communications (Nature) Canada, USA, Germany, 06 April 2023
Osteology
Key words: Biochemical networks, Proteases, Proteolysis, Rheumatology [more]
Organism: Human
Tissue: Joint Tissue
Pathological State: Osteoarthritis
Prognostic values of tissue-resident CD8+ T cells in human hepatocellular carcinoma and intrahepatic cholangiocarcinoma
World Journal of Surgical Oncology (BMC) China, 06 April 2023
Oncology
Key words: Hepatocellular carcinoma, Intrahepatic Cholangiocarcinoma, Multicolor immunohistochemistry, Prognosis, Tissue-resident CD103+CD8+T cells [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma
Cancer Biology & Medicine (China Anti-Cancer Association) China, 05 April 2023
Oncology, Machine Learning
Key words: Artificial intelligence, CD8, CSCs, tumor budding, PDAC, nomogram [more]
Organism: Human
Tissue: Pancreas
Hypoxia switches TET1 from being tumor-suppressive to oncogenic
Oncogene (Nature) China, 05 April 2023
Oncology
Key words: Cancer microenvironment, Oncogenes [more]
Organism: Mouse
Tissue: Thyroid
Pathological State: Cancer
Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses
Cell Metabolism (Cell Press) China, Japan, 04 April 2023
Immunology
Key words: CD36, acetylcholine, autoreactive B cell responses, choline acetyltransferase, fibroblastic reticular cells, lipid metabolism, mitochondrial respiration, spleen, systemic lupus erythematosus [more]
Organism: Mouse
Tissue: Spleen
Molecules of senescent glial cells differentiate Alzheimer's disease from ageing
Journal of Neurology, Neurosurgery & Psychiatry (BMJ Journals) China, Sweden, UK, USA, 04 April 2023
Neuroscience
Organism: Human
Tissue: Brain
Pathological State: Alzheimer's disease
Red blood cell extracellular vesicles deliver therapeutic siRNAs to skeletal muscles for treatment of cancer cachexia
Molecular Therapy (Cell Press) Singapore, China, 04 April 2023
Oncology
Key words: extracellular vesicles, cancer cachexia, siRNA, RNA delivery, myostatin, malonyl-CoA decarboxylase [more]
Organism: Mouse
Tissue: Muscle
Characterization and Advancement of an Evaluation Method for the Treatment of Spontaneous Osteoarthritis in STR/ort Mice: GRGDS Peptides as a Potential Treatment for Osteoarthritis
Biomedicines (MDPI) Taiwan, 02 April 2023
Osteology
Key words: Osteoarthritis, STR/ort, cartilage, matrix metallopeptidase-13, SRY-box transcription factor 91 [more]
Organism: Mouse
Tissue: Joint Tissue
Pathological State: Osteoarthritis
A Deep-Learning-Computed Cancer Score for the Identification of Human Hepatocellular Carcinoma Area Based on a Six-Colour Multiplex Immunofluorescence Panel
Cells (MDPI) Germany, The Netherlands, 02 April 2023
Osteology, Machine Learning
Key words: hepatocellular carcinoma, HCC, convolutional neural network, CNN, U-net, multiplex, fluorescence, immunofluorescence, microscopy, cancer score [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
Analysis of Single- and Double-Stranded DNA Damage in Osteoblastic Cells after Hyperbaric Oxygen Exposure
Antioxidants (MDPI) Germany, USA, 01 April 2023
Pharmacology
Key words: oxidative stress; DNA damage; osteoblasts; gamma-H2AX; hyperbaric hyperoxia; comet assay; DSBs [more]
Organism: Human
Pathological State: Oxidative Stress
Cell Line: SAOS-2
Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue
iScience (Cell Press) China, 01 April 2023
Cell Biology
Key words: β-catenin, UCP1, thermogenesis, beige adipocytes, energy expenditure [more]
Organism: Mouse
Tissue: Adipose Tissue
DARPP‐32 cells and neuropil define striosomal system and isolated matrix cells in human striatum
Journal of Comparative Neurology (Wiley) New Zealand, USA, 31 March 2023
Neuroscience
Key words: DARPP-32, spinyprojectionneurons, striatum, striosomes [more]
Organism: Human
Tissue: Brain
High bacillary burden and the ESX-1 type VII secretion system promote MHC class I presentation by Mycobacterium tuberculosis infected macrophages to CD8 T-cells
The Journal of Immunology (AHA Journals) USA, 31 March 2023
Immunology, Microbiology
Optimizing culturing conditions in patient derived 3D primary slice cultures of head and neck cancer
Frontiers in Oncology (Frontiers Media S.A.) Austria, 30 March 2023
Biological Methods, Oncology
Key words: head and neck cancer, tumor microenvironment, cultured neoplastic cells, platelet rich fibrin, culture media [more]
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy
Brain Pathology (Wiley) China, 28 March 2023
Neuroscience
Key words: antioxidant, Mic60, mitochondria, mitochondrial encephalomyopathies, neurodegeneration, reactive oxygen species [more]
Organism: Mouse
Tissue: Brain
CD226 identifies functional CD8+ T cells in the tumor microenvironment and predicts a better outcome for human gastric cancer
Frontiers in Immunology (Frontiers Media S.A.) China, 28 March 2023
Oncology, Gastroenterology
Key words: CD226, CD8+ T cells, multi-color immunohistochemical staining, prognosis, gastric cancer [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
Protective effects of resveratrol on the ethanol‐induced disruption of retinogenesis in pluripotent stem cell‐derived organoids
FEBS Open Bio (Wiley) China, 27 March 2023
Ophthalmology
Key words: ethanol, fetal alcohol syndrome, PI3K-AKT signalling, resveratrol, retinal organoids [more]
Cell Line: Human embryonic stem cells
Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages
Theranostics (Ivyspring International Publisher) China, 27 March 2023
Immunology, Oncology
Key words: Platelets, TAMs, CRC, PSGL-1/JNK/STAT1, C5a/C5aR1 [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Functional Peptide-Loaded Gelatin Nanoparticles as Eyedrops for Cornea Neovascularization Treatment
International Journal of Nanomedicine (Taylor & Francis) Taiwan, Australia, 23 March 2023
Nanomedicine, Ophthalmology
Key words: gp91 peptide, gelatin, nanoparticles, ocular retention, control release, corneal neovascularization, eye drops [more]
Organism: Mouse
Tissue: Eye
Pathological State: Corneal neovascularization
Occurrence, risk assessment, and in vitro and in vivo toxicity of antibiotics in surface water in China
Ecotoxicology and Environmental Safety (Elsevier) China, 22 March 2023
Toxicology, Ecology
Key words: Antibiotics, Environmental pollution, Surface water, Intestinal flora, Oxidative stress [more]
Organism: Mouse
Tissue: Liver
Dual-Ratiometric Magnetic Resonance Tunable Nanoprobe with Acidic-microenvironment-responsive Property to Enhance the Visualization of Early Tumor Pathological Changes
Nano Research (Sciopen) China, USA, Australia, 22 March 2023
Nanomedicine, Oncology
Key words: ratiometric nanoprobe, dually activatable, microenvironment visualization, early diagnosis, pathological changes [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization
Journal of Ovarian Research (BMC) China, 21 March 2023
Reproductive Medicine
Key words: Placental mesenchymal stem cells, Premature ovarian insufficiency, Macrophage, Inflammasome, NLRP3, Interferon-γ, Pyroptosis [more]
Organism: Rat
Tissue: Ovaries
Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy
Nature Communications (Nature) USA, 21 March 2023
Immunology, Transplantation Medicine
Key words: Graft-versus-host disease, Immunotherapy, Kidney, Transplant immunology, Tumour immunology [more]
Organism: Human
Tissue: Skin, Lymphoid Tissue, Kidney
Pathological State: Graft-versus-host disease
Analysis of the mechanism underlying diabetic wound healing acceleration by Calycosin-7-glycoside using network pharmacology and molecular docking
Phytomedicine (Elsevier) China, 20 March 2023
Pharmacology
Key words: Diabetic wound healing, Calycosin-7-glucoside, Mitochondrial metabolism, Macrophage polarization, Network pharmacology, Molecular docking [more]
Organism: Mouse
Tissue: Skin
Pathological State: Imnflammation
Intrinsic RIG-I restrains STAT5 activation to modulate anti-tumor activity of CD8+ T cells
The Journal of Clinical Investigation (American Society for Journal of Clinical Investigation) China, 16 March 2023
Immunology, Oncology
Key words: RIG-I, Tumor-infiltrating CD8+ , T cell, STAT5 activation, Colon cancer [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Thorium (IV) Triggers Ferroptosis through Disrupting Iron Homeostasis and Heme Metabolism in the Liver Following Oral Ingestion
Journal of Hazardous Materials (Elsevier) China, 15 March 2023
Hepatology
Key words: Thorium, Hepatotoxicity, Ferroptosis, Iron homeostasis, Heme metabolism [more]
Organism: Mouse
Tissue: Liver
Fast and sensitive GCaMP calcium indicators for imaging neural populations
Nature (Nature) USA, 15 March 2023
Neuroscience
Key words: Fluorescent proteins, Neural circuits [more]
Organism: Mouse
Tissue: Brain
Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer
British Journal of Cancer (Nature) Austria, Hungary, Sweden, 14 March 2023
Oncology
Key words: Small-cell lung cancer [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma
Gastroenterology (Elsevier) China, USA, 14 March 2023
Oncology
Key words: Gastric Cancer, T-Cell State, CXCL13, Immune Checkpoint Blockade [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
Expression of Checkpoint Molecules in the Tumor Microenvironment of Intrahepatic Cholangiocarcinoma: Implications for Immune Checkpoint Blockade Therapy
Cells (MDPI) Germany, The Netherlands, USA, UK, 09 March 2023
Oncology, Immunology
Key words: cholangiocarcinoma, tumor microenvironment, checkpoint molecules, multiplexed imaging, immunotherapy [more]
Organism: Human
Tissue: Bile duct, Liver
Pathological State: Cancer
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
PNAS (Proceedings of the National Academy of Sciences of the United States of America) USA, 09 March 2023
SARS-CoV-2, Immunology
Key words: SARS-COV-2, antisense oligos, small interfering RNAs, mouse model, lung [more]
Organism: Mouse
Tissue: Lung
Pathological State: Covid-19
Effects of paraprobiotics on bile acid metabolism and liver health in largemouth bass (Micropterus salmoides) fed a cottonseed protein concentrate-based diet
Animal Nutrition (Elsevier) China, France, 07 March 2023
Zoology
Key words: Cottonseed protein concentrate, Multi-yeast strain fractions, Micropterus salmoides, Liver health, Bile acid metabolism, Gut microbiota [more]
Organism: Bass Fish
Tissue: Liver, Small Intestine
In Situ Formation of Injectable Gelatin Methacryloyl (GelMA) Hydrogels for Effective Intraocular Delivery of Triamcinolone Acetonide
International Journal of Molecular Sciences (MDPI) China, 04 March 2023
Pharmacology
Key words: gelatin methacryloyl, triamcinolone acetonide, retina hydrogel system, hydrogel drug release, intraocular drug delivery, injectable gel [more]
Organism: Rabbit
Tissue: Eye
The protective effect of cannabinoids against colorectal cancer cachexia through modulation of inflammation and immune responses
Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 03 March 2023
Immunology, Oncology
Key words: Colorectal cancer cachexia, Cytokines, Cannabinoids, CD8+ T cell, Cannabinoid receptor 2 [more]
Organism: Mouse
Tissue: Colon
Pathological State: Cancer
Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration
Cells (MDPI) Taiwan, 03 March 2023
Aging
Key words: melatonin, endothelial progenitor cells, vascular endothelial growth factor (VEGF), platelet-derived growth factor-BB (PDGF-BB), angiogenesis, neovascular age-related macular degeneration [more]
Cell Line: Endothelial progenitor cells
miR-194 upregulates CYP7A1 expression via β-catenin signaling and aggravates cholestatic liver diseases
The American Journal of Pathology (Elsevier) Taiwan, 02 March 2023
Hepatology
Organism: Mouse
Tissue: Liver
Androgen therapy does not prevent bone loss and arterial calcifications in male rats with CKD
Journal of Endocrinology (Society for Endocrinology) Belgium, 01 March 2023
Endocrinology
Key words: androgen replacement therapy, chronic kidney disease, hypogonadism, bone loss, arterial calcification [more]
Organism: Rat
Tissue: Blood Vessels
Pathological State: Kidney disease
Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells
Journal of the Endocrine Society (Oxford Academic) China, 28 February 2023
Oncology
Key words: mitochondrial fusion, testosterone, granulosa cells, steroidogenic acute regulatory protein, sex hormones, polycystic ovary syndrome [more]
Organism: Human
Tissue: Ovaries
Pathological State: Cancer
Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo
Small (Wiley) Austria, 26 February 2023
Nanomedicine
Key words: biodistribution, bottlebrush polymers, nanomedicine, pharmacokinetics, polyglutamate, polymer therapeutics, polyphosphazenes [more]
Organism: Mouse
Tissue: Bone, Kidney, Xenograft Tumor
Pathological State: Cancer
Electrical Sympathetic Neuromodulation Protects Bone Marrow Niche and Drives Hematopoietic Regeneration during Chemotherapy
Small Methods (Wiley) Taiwan, USA, 26 February 2023
Neuroscience
Key words: bone marrow niche, chemotherapy-induced nerve damage, electrical neuromodulation, hematopoiesis [more]
Organism: Rat
Tissue: Bone
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke
Cell Death & Disease (Nature) China, 25 February 2023
Neuroscience
Key words: Stroke [more]
Organism: Mouse
Tissue: Brain
Pathological State: Cerebral Ischemia
UHRF1/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer
Acta Pharmaceutica Sinica B (Elsevier) China, 24 February 2023
Oncology
Key words: Lung cancer, Intratumor heterogeneity, Splice variants, Intragenic CpG methylation, Protease serine 3, Myeloid zinc finger 1, UHRF1/DNMT1, 5-Aza-CdR [more]
Organism: Mouse
Tissue: Xenograft Tumor, Lung
Pathological State: Cancer
Immune Microenvironment in Sporadic Early-Onset versus Average-Onset Colorectal Cancer
Cancers (MDPI) Sweden, USA, Uganda, 24 February 2023
Oncology
Key words: early-onset colorectal cancer, tumor microenvironment, tumor-infiltrating lymphocytes, gene expression, immunofluorescence [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Transgenic HPV11-E2 protein modulates URR activity in vivo
Transgenic Research (Springer) Germany, 24 February 2023
Virology
Key words: HPV-E2, Human papillomavirus type 11, Reporter gene, Transgenic mouse model, Upstream regulatory region URR [more]
Organism: Mouse
Tissue: Skin
Poly (I: C) Exacerbates Airway Goblet Cell Hyperplasia and Lung Inflammation in HDM-Exposed Balb/C Mice by YAP/FOXM1 Pathway
International Archives of Allergy and Immunology (Karger) China, 23 February 2023
Immunology
Key words: YAP, Poly(I:C), Asthma, Airway inflammation, Goblet cell hyperplasia
Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging
Medicina (MDPI) Romania, 22 February 2023
Cardiology
Key words: arterial stiffness, cardiovascular risk, morbid obesity, pulse wave analysis, adiponectin, chemerin, adipocyte [more]
Organism: Human
Tissue: Adipose Tissue
Pathological State: Obesity
Oolong tea of different years protects high-fat diet-fed mice against obesity by regulating lipid metabolism and modulating gut microbiota
Food & Function (Royal Society of Chemistry) China, 21 February 2023
Endocrinology
SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway
Journal of Leukocyte Biology (Oxford Academic) China, 20 February 2023
Oncology
Key words: breast cancer, early-stage myeloid-derived suppressor cells, Wnt/mTOR pathway, autophagy [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Intestinal Farnesoid X Receptor Modulates Duodenal Surface Area but Does Not Control Glucose Absorption in Mice
International Journal of Molecular Sciences (MDPI) The Netherlands, 18 February 2023
Gastroenterology
Key words: glucose absorption, intestinal FXR, duodenum, GS3972 [more]
Organism: Mouse
Tissue: Small Intestine
MRI histogram analysis of tumor-infiltrating CD8+ T cell levels in patients with glioblastoma
NeuroImage: Clinical (Elsevier) China, 18 February 2023
Oncology
Key words: Glioblastoma, Magnetic resonance imaging, Histogram analysis, CD8+ T cells, Tumor microenvironment [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Bavachinin Protects the Liver in NAFLD by Promoting Regeneration via Targeting PCNA
Journal of Advanced Research (Elsevier) China, 16 February 2023
Hepatology
Key words: Bavachinin, CC-ABPP, NAFLD, Liver regeneration, PCNA [more]
Organism: Hamster
Tissue: Liver
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease
Nature Biomedical Engineering (Nature) China, 16 February 2023
Neuroscience
Key words: Huntington's disease, Preclinical research [more]
Organism: Pig
Tissue: Brain
Pathological State: Huntington's Disease
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer
Immunity (Cell Press) USA, 14 February 2023
Immunology, Oncology
Key words: regulatory T cells, cross-presenting dendritic cells, cytotoxic T cells, T cell dysfunction, T cell priming, anti-tumor immunity, non-small cell lung cancer, interferon-gamma, Th1-like effector regulatory T cells, tissue-specific immunity [more]
Tissue: Lymphoid Tissue
Pathological State: Cancer
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation
Immunity (Cell Press) Austria, 14 February 2023
Immunology
Organism: Human
Tissue: Skin
Pathological State: Lesional Sarcoidosis
Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-specific Pathways
Journal of The American Society of Nephrology (Wolters Kluwer) USA, 14 February 2023
Nephrology
Organism: Mouse
Tissue: Kidney
Pathological State: Renal Ischemia
CD39-Expressing CD8+ T Cells as a New Molecular Marker for Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma
Cancers (MDPI) China, 13 February 2023
Oncology
Key words: esophageal squamous cell carcinoma, CD39+CD8+ T cells, diagnosis, prognosis, nomogram, tumor microenvironment [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis
Cell Death & Disease (Nature) China, 13 February 2023
Oncology
Key words: Cancer microenvironment, Kupffer cells, Metastasis, Tumour angiogenesis [more]
Organism: Mouse
Tissue: Liver, Allograft Tumor
Pathological State: Cancer
Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1
Cell Death & Disease (Nature) China, 13 February 2023
Oncology
Key words: Cancer prevention, Proteomics, Target identification [more]
Organism: Mouse
Tissue: Xenograft Tumor, Skin
Pathological State: Cancer
Prevalence of tumour-infiltrating CD103+ cells identifies therapeutic-sensitive prostate cancer with poor clinical outcome
British Journal of Cancer (Nature) China, 09 February 2023
Oncology
Key words: Cancer microenvironment, Immune evasion, Prognostic markers [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
Tissue‐resident CXCR4+ macrophage as a poor prognosis signature promotes pancreatic ductal adenocarcinoma progression
International Journal of Cancer (Wiley) China, 09 February 2023
Oncology
Key words: CXCR4, pancreatic ductal adenocarcinoma, prognosis, SPARC, tissue-resident macrophage [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Skin infiltrate composition as a telling measure of responses to checkpoint inhibitors.
JID Innovations (Elsevier) USA, 09 February 2023
Oncology
Organism: Human
Tissue: Skin
Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet‐Induced Adiposity
Advanced Science (Wiley) China, 08 February 2023
Endocrinology
Key words: obesity, pathogenic gene, RSPO1, thermogenesis, whole-exome sequenc-ing, Wnt signaling [more]
Organism: Mouse
Tissue: Adipose Tissue
Artificial Base-Directed In Vivo Assembly of an Albumin–siRNA Complex for Tumor-Targeting Delivery
ACS Applied Materials & Interfaces (ACS Publications) China, 07 February 2023
Oncology, Pharmacology
Key words: artificial base, siRNA, albumin, targeted delivery, long circulation, tumor accumulation [more]
Organism: Mouse
Tissue: Heart, Kidney, Liver, Spleen, Lung
Artificial Base-Directed In Vivo Assembly of an Albumin–siRNA Complex for Tumor-Targeting Delivery
ACS Applied Materials & Interfaces (ACS Publications) China, 07 February 2023
Pharmacology, Oncology
Empagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis
Cardiovascular Diabetology (Springer) Taiwan, Vietnam, 06 February 2023
Cardiology
Key words: Fibroblasts, Fibrosis, Empagliflozin, Sodium-glucose co-transporter 2, Calcium, Sodium-Hydrogen exchanger [more]
Organism: Rat
Tissue: Heart
Pathological State: Atrial fibrosis
Synthesis and Anti-Melanoma Activity of L-Cysteine-Coated Iron Oxide Nanoparticles Loaded with Doxorubicin
Nanomaterials (MDPI) Romania, 04 February 2023
Nanomedicine
Key words: magnetic nanoparticles, melanoma, L-Cys, Dox, chemotherapeutic [more]
Cell Line: B16F10 melanoma murine cell line, CCD1070SK fibroblast and melanoma A375 human cell lines
The Role of Green Tea Catechin Epigallocatechin Gallate (EGCG) and Mammalian Target of Rapamycin (mTOR) Inhibitor PP242 (Torkinib) in the Treatment of Spinal Cord Injury
Antioxidants (MDPI) Czech Republic, USA, 03 February 2023
Neuroscience
Key words: spinal cord injury, mTOR pathway, EGCG, PP 242, inflammatory response, neuroregeneration, astrogliosis, axonal growth [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Amentoflavone induces caspase‐dependent/− independent apoptosis and dysregulates cyclin‐dependent kinase‐mediated cell cycle in colorectal cancer in vitro and in vivo
Environmental Toxicology (Wiley) Taiwan, 02 February 2023
Oncology
Organism: Mouse
Tissue: Colon, Xenograft Tumor
Pathological State: Cancer
PKCδ promotes the invasion and migration of colorectal cancer through c-myc/NDRG1 pathway
Frontiers in Oncology (Frontiers Media S.A.) China, 02 February 2023
Oncology
Key words: colorectal cancer, protein kinase C δ, N-myc downstream-regulated gene 1, metastasis, epithelial-mesenchymal transition [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Mapping thalamic innervation to individual L2/3 pyramidal neurons and modeling their 'readout'of visual input
Nature Neuroscience (Nature) USA, South Korea, Israel, 02 February 2023
Neuroscience
Key words: Sensory processing, Striate cortex [more]
Organism: Mouse
Tissue: Brain
Apolipoprotein E negatively regulates allergic airway inflammation and remodeling in mice with OVA-induced chronic asthma
International Immunology (Elsevier) China, 01 February 2023
Allergy Research
Key words: ApoE, Airway remodeling, Chronic airway inflammation, Th2 responses [more]
Organism: Mouse
Tissue: Lung
Pathological State: Asthma
Overexpression of Both Human Sodium Iodide Symporter (NIS) and BRG1-Bromodomain Synergistically Enhances Radioiodine Sensitivity by Stabilizing p53 through NPM1 Expression
International Journal of Molecular Sciences (MDPI) South Korea, 01 February 2023
Oncology
Key words: sodium iodide symporter, radioiodine therapy, iodine-131, brahma-related gene 1 bromodomain, radiosensitization, thyroid cancer [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models
PNAS (Proceedings of the National Academy of Sciences of the United States of America) USA, Poland, Norway, 01 February 2023
Immunology, Oncology
Key words: immune checkpoint blockers, glioblastoma, immune-related adverse events, tumor microenvironment , biomarkers [more]
Organism: Mouse
Tissue: Brain, Xenograft Tumor
Pathological State: Cancer
Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression
Science Advances (Science) China, 27 January 2023
Oncology
Organism: Human
Tissue: Endometrium
Pathological State: Cancer
Development and Characterization of a Highly Selective Turn-On Fluorescent Ligand for β3-Adrenergic Receptor
Analytical Chemistry (ACS Publications) China, 26 January 2023
Biological Methods
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Lingguizhugan decoction improves non-alcoholic steatohepatitis partially by modulating gut microbiota and correlated metabolites
Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) China, 26 January 2023
Hepatology
Key words: Lingguizhugan decoction, NASH, MCD diet, gut microbiota, metabolomics [more]
Organism: Rat
Tissue: Liver
Pathological State: Non-alcoholic steatohepatitis
New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma
Frontiers in Oncology (Frontiers Media S.A.) Romania, 26 January 2023
Oncology
Key words: melanoma biomarkers, amelanotic melanoma, mass spectrometry, proteomics, melanoma diagnostic, melanoma prognostic [more]
Pathological State: Cancer
Cell Line: A375, SKMEL28, SKMEL23 and MNT1 cells
Transcriptional Regulation of Math1 by Aryl Hydrocarbon Receptor: Effect on Math1+ Progenitor Cells in Mouse Small Intestine
Molecular and Cellular Biology (Taylor & Francis) USA, 26 January 2023
Gastroenterology
Key words: AhR, Math1, intestinal organoids, Math1+ progenitor cells, goblet cells
PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon
International Immunology (Oxford Academic) Japan, China, 25 January 2023
Immunology
Key words: PCBP1, macrophage, CCL2, IBD, proinflammatory cytokine
Intravenous aav9 administration results in safe and widespread distribution of transgene in the brain of mini-pig
Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 24 January 2023
Neuroscience
Key words: AAV9, CNS, large animal, pig, neurodegeneration [more]
Organism: Pig
Tissue: Brain
LRRC3B and its promoter hypomethylation status predicts response to anti-PD-1 based immunotherapy
Frontiers in Immunology (Frontiers Media S.A.) China, 24 January 2023
Oncology, Immunology
Key words: pan-cancer, tumor immune microenvironment, immunotherapy, leucine rich repeat containing 3B, DNA methylation [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Glycoside combinations of Buyang Huanwu decoction ameliorate atherosclerosis via STAT3, HIF-1, and VEGF
Naunyn-Schmiedeberg's Archives of Pharmacology (Springer) China, 24 January 2023
Cardiology, Pharmacology
Key words: Network pharmacology, Buyang Huanwu decoction, Glycoside combination, Atherosclerosis, Angiogenesis [more]
Organism: Mouse
Tissue: Blood Vessels
Pathological State: Atherosclerosis
Melatonin improves muscle injury and differentiation by increasing Pax7 expression
International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan, 22 January 2023
Pharmacology
Key words: melatonin, Pax7, muscle injury, differentiation, miR-3475-3p [more]
Organism: Mouse
Tissue: Muscle
Pathological State: Muscle injury
Modulatory Effects of Heat-Inactivated Streptococcus Thermophilus Strain 7 on the Inflammatory Response: A Study on an Animal Model with TLR3-Induced Intestinal Injury
Microorganisms (MDPI) Taiwan, Malaysia, 20 January 2023
Microbiology, Immunology
Key words: Streptococcus thermophilus, microbiota, poly I:C, inflammation, IL-15 [more]
Organism: Mouse
Tissue: Small Intestine
Pathological State: TLR3-Induced Intestinal Injury
Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?
International Journal of Molecular Sciences (MDPI) Austria, Germany, Switzerland, 19 January 2023
Neuroscience
Key words: nerve regeneration, cochlear implant, spiral ganglion, neurotrophin treatment, electrical stimulation [more]
Cell Line: Murine spiral ganglion neurons
Engineering orthotopic tumor spheroids with organ-specific vasculatures for local chemoembolization evaluation
Biomaterials Science (Royal Society of Chemistry) China, Singapore, 17 January 2023
Biological Methods
Prognostic role of the innate immune signature CD163 and “eat me” signal calreticulin in clear cell renal cell carcinoma
Cancer Immunology, Immunotherpay (Springer) Japan, 17 January 2023
Oncology
Key words: Renal cell carcinoma, Kidney cancer, Innate immunity, CD163, Tumor-associated macrophage, Calreticulin, Eat me signal, Survival [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington's disease
Nature Communications (Nature) USA, 17 January 2023
Neuroscience
Key words: Huntington's disease, Molecular neuroscience, Transcriptomics [more]
Organism: Mouse
Tissue: Brain
Pathological State: Huntington's disease
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
Cells (MDPI) Austria, 16 January 2023
Oncology
Key words: HNSCC, erastin, xCT, ERK signaling [more]
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Environmental endocrine disruptor Bisphenol A induces metabolic derailment and obesity via upregulating IL-17A in adipocytes
Environment International (Elsevier) China, 16 January 2023
Endocrinology
Key words: Obesity, Bisphenol A, Inflammation, Insulin resistance, IL-17A [more]
Organism: Mouse
Tissue: Adipose Tissue
Pathological State: Obesity
Daurisoline suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting MEK1/2 kinase
Molecular Carcinogenesis (Wiley) China, 16 January 2023
Oncology
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti‐PD‐1/PD‐L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity
Advanced Science (Wiley) China, 15 January 2023
Oncology, Pharmacology
Organism: Human
Tissue: Bladder
Pathological State: Cancer
miR-432 exerts a protective effect against myocardial ischemia/reperfusion injury by activating the β-catenin/HIF-1α pathway and augmenting NRF2-mediated anti-oxidative stress
American Journal of Translational Research (e-Century Publishing Corporation) China, 15 January 2023
Cardiology
Key words: apoptosis, microRNA, myocardial ischemia/reperfusion injury, oxidative stress [more]
Organism: Mouse
Tissue: Heart
Pathological State: Myocardial Ischemia
Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia–reperfusion injury
Annals of Translational Medicine (AME Publishing Company) China, 15 January 2023
Ophthalmology
Key words: Lipocalin-2 (LCN2), retinal ischemia-reperfusion injury (RIR injury), ferroptosis, retinal ganglion cell (RGC), visual impairment [more]
Organism: Mouse
Tissue: Eye
Pathological State: Retinal Ischemia
SN‐38, an active metabolite of irinotecan, enhances anti‐PD1 treatment efficacy in head and neck squamous cell carcinoma
The Journal of Pathology (Wiley) Taiwan, USA, 15 January 2023
Oncology
Organism: Human
Tissue: Head and Neck
Pathological State: Cancer
Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice
Neuroscience Bulletin (Springer) China, 13 January 2023
Neuroscience
Key words: Microglia, Mechanical allodynia, Laterality, Spinal dorsal horn, Aβ, Dynamic allodynia, Punctate allodynia [more]
Organism: Mouse
Tissue: Brain, Spinal Cord
Pathological State: Mechanical Allodynia
Production and characterization of cell-penetrating recombinant botulinum neurotoxin type A
STAR Protocols (Elsevier) China, 13 January 2023
Biological Methods
Key words: Cell culture, Protein Biochemistry, Protein Expression and Purification, Biotechnology and Bioengineering [more]
Cell Line: N2a cells
The imbalance of NKG2A and NKG2D expression is involved in NK cell immunosuppression and tumor progression of HBV‐HCC patients
Hepatology Research (Wiley) China, 11 January 2023
Oncology
Key words: NK cell, NKG2A, NKG2D, hepatitis B virus-related hepatocellular carcinoma, immunosuppression [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
Theabrownin inhibits obesity and non-alcoholic fatty liver disease in mice via serotonin-related signaling pathways and gut-liver axis
Journal of Advanced Research (Elsevier) China, 11 January 2023
Hepatology
Key words: non-alcoholic fatty liver disease, anti-obesity, theabrownin, serotonin, gut microbiota [more]
Organism: Mouse
Tissue: Liver
Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth
Advanced Science (Wiley) China, USA, 10 January 2023
Oncology
Key words: 3-HA, 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), 5-HT, ferroptosis, kynureninase (KYNU, monoamine oxidase A (MAOA), tryptophan [more]
Organism: Human
Tissue: Liver, Kidney
Pathological State: Cancer
Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy
Human Cell (Springer) China, 10 January 2023
Cardiology
Key words: OSAS, CIH, Autophagy, BNIP3, Apoptosis, Cardiac hypertrophy [more]
Organism: Rat
Tissue: Heart
Pathological State: Contractile dysfunction
Immune dysregulation in immunoglobulin G4–related disease
Japanese Dental Science Review (Elsevier) Japan, 09 January 2023
Immunology
Key words: Autoimmune, Anti-inflammatory, Single-cell RNA sequencing, IgG4-related disease, Cytotoxic T cells, Salivary gland
Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive 18F-FDG PET/CT and Serum 1H-NMR Analysis: An Orthotopic Murine Model Study
Metabolites (MDPI) Taiwan, 09 January 2023
Oncology
Key words: lung cancer, 18F-FDG, 1H-NMR, animal study, metastasis [more]
Organism: Mouse
Tissue: Xenograft Tumor, Lung
Pathological State: Cancer
Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance
Neuroscience Bulletin (Springer) China, 09 January 2023
Neuroscience
Key words: μ-opioid receptor, Morphine, Mechanical allodynia, Punctate allodynia, Dynamic allodynia, OIH, Tolerance, Aβ-fiber [more]
Organism: Mouse
Tissue: Brain, Spinal Cord
Pathological State: Mechanical Allodynia
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity
Science Advances (Science) USA, China, 06 January 2023
Oncology
Organism: Human
Tissue: Breast
Pathological State: Cancer
Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts
Cellular Oncology (Springer) Taiwan, 06 January 2023
Oncology
Key words: Acetyl-CoA carboxylase α, Breast cancer, Metabolism reprogramming, Pre-metastatic niche, Senescence [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Role of iodine density value on dual-energy CT for detection of high tumor cell proportion region in lung cancer during CT-guided transthoracic biopsy
European Journal of Radiology (Elsevier) China, 06 January 2023
Oncology, Radiotherapy
Key words: Dual-layer spectral detector computed tomography, Iodine density, Transthoracic lung biopsy, High tumor cell proportion region [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis
Experimental & Molecular Medicine (Nature) South Korea, 06 January 2023
Cell Biology
Key words: Calcification, Stress signalling [more]
Organism: Mouse
Tissue: Blood Vessels
PLVAP as an Early Marker of Glomerular Endothelial Damage in Mice with Diabetic Kidney Disease
International Journal of Molecular Sciences (MDPI) Germany, 06 January 2023
Nephrology
Key words: diabetic kidney disease, endothelial damage, PLVAP, diabetic models, glomerular hypertrophy [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Diabetic Kidney Disease
The transcription factor Eomes promotes expression of inhibitory receptors on hepatic CD8+ T cells during HBV persistence
The FEBS Journal (Wiley) China, 05 January 2023
Virology, Immunology
Key words: CD8+ T cell exhaustion, chronic HBV persistence, Eomes, inhibitory receptor, transcription factor [more]
Organism: Mouse
Tissue: Liver
Pathological State: Hepatitis B virus Infection
Comparing the Therapeutic Mechanism and Immune Response of Human and Mouse Mesenchymal Stem Cells in Immunocompetent Mice With Acute Liver Failure
Stem Cells Translational Medicine (Oxford Academic) Taiwan, 04 January 2023
Immunology, Hepatology
Key words: mesenchymal stem cells, immunomodulatory, IL-6, F4/80, liver regeneration, liver fibrosis [more]
Organism: Mouse
Tissue: Liver
Pathological State: Acute Liver Failure
Limonin counteracts obesity by activating thermogenesis in brown and white adipose tissues
Journal of Functional Foods (Elsevier) China, 02 January 2023
Endocrinology
Key words: Limonin, Obesity, Brown adipose tissue, White adipose tissues, Thermogenesis [more]
Organism: Mouse
Tissue: Liver
Nesfatin-1 stimulates CCL2-dependent monocyte migration and M1 macrophage polarization: implications for rheumatoid arthritis therapy
International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan, 01 January 2023
Rheumatology
Key words: rheumatoid arthritis, nesfatin-1, CCL2, M1 macrophages, synovial fibroblasts [more]
Organism: Human, Mouse
Tissue: Joint Tissue
Pathological State: Rheumatoid Arthritis
Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma
International Journal of Molecular Sciences (MDPI) Singapore, USA, 01 January 2023
Oncology
Key words: neutrophils, pancreatic cancer, hypoxia-inducible factor 1-alpha [more]
Organism: Mouse
Tissue: Xenograft Tumor, Pancreas
Pathological State: Cancer
The TgF344-AD Rat: Behavioral and Proteomic Changes Associated with Aging and Protein Expression in a Transgenic Rat Model of Alzheimer's Disease
Neurobiology of Aging (Elsevier) USA, 30 December 2022
Neuroscience
Key words: watermaze, 6E10, pTau, neuroinflammation, TREM2, Learning Index, proteomics [more]
Organism: Rat
Tissue: Brain
Pathological State: Alzheimer's Disease
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma
Frontiers of Medicine (Springer) China, 29 December 2022
Oncology
Key words: benzydamine, cyclin-dependent kinase 2, patient-derived xenograft, esophageal squamous cell carcinoma [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
The effect of isovitexin on lipopolysaccharide-induced renal injury and inflammation by induction of protective autophagy
Food and Chemical Toxicology (Elsevier) Taiwan, 23 December 2022
Nephrology
Key words: Kidney injury, Isovitexin, Lipopolysaccharide, Inflammation, Autophagy [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Lipopolysaccharide-induced kidney injury
Myofibroblast stroma differentiation in infiltrative basal cell carcinoma is accompanied by regulatory T‐cells
Journal of Cutaneous Pathology (Wiley) Austria, 23 December 2022
Oncology
Key words: Basal cell carcinoma, infiltrative BCC, regulatory T-cells, TGF-β, alpha smooth muscle actin [more]
Organism: Human
Tissue: Skin
Pathological State: Cancer
Mitigation of Cellular and Bacterial Adhesion on Laser Modified Poly (2-Methacryloyloxyethyl Phosphorylcholine)/Polydimethylsiloxane Surface
Nanomaterials (MDPI) Romania, 23 December 2022
Tissue Engineering
Key words: MAPLE, zwitterionic coating, cellular response [more]
Cell Line: Fibroblasts cultured on PDMS scaffolds
Biomimetic Prussian blue nanozymes with enhanced bone marrow-targeting for treatment of radiation-induced hematopoietic injury
Biomaterials (Elsevier) China, 21 December 2022
Nanomedicine
Key words: Prussian blue nanozymes, Mesenchymal stem cell membrane, Reactive oxygen species, Radiation-induced hematopoietic injury, Targeting therapy [more]
Organism: Mouse
Tissue: Bone
Pathological State: Radiation-induced hematopoietic injury
Avicularin Alleviates Osteoporosis in Ovariectomized Mice by Inhibiting Osteoclastogenesis through NF-κB Pathway Inhibition
Journal of Agricultural and Food Chemistry (ACS Publications) China, 20 December 2022
Osteology
Key words: osteoclast avicularin bone loss NF-κB [more]
Organism: Mouse
Tissue: Bone
R158Q and G212S, novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome
Frontiers of Medicine (Frontiers Media S.A.) China, 19 December 2022
Endocrinology
Key words: Gitelman syndrome, mouse model, compound heterozygous, hypokalemia, Slc12a3 [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Gitelman syndrome
A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging
Nature Biomedical Engineering (Nature) China, 19 December 2022
Biological Methods
Key words: Biomedical engineering, Magnetic resonance imaging [more]
Organism: Pig
Tissue: Liver
Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies
Frontiers in Pharmacology (Frontiers Media S.A.) The Netherlands, 18 December 2022
Neuroscience
Key words: asthma, cholinergic, neuron, organ-on-chip, stem cell [more]
Cell Line: Airway cholinergic neurons
Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice
Nature Communications (Nature) Singapore, USA, UK, 17 December 2022
Aging
Key words: Ageing, Muscle stem cells, Skeletal muscle [more]
Organism: Mouse
Tissue: Muscle
Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10
Cancer Letters (Elsevier) USA, 17 December 2022
Oncology
Key words: KRAS, Non-small cell lung cancer, Pcdh10, Gene regulation, Miz1 [more]
Organism: Mouse
Tissue: Lung
FOXM1 increases hTERT protein stability and indicates poor prognosis in gastric cancer
Neoplasia (Elsevier) China, 16 December 2022
Oncology
Key words: Gastric cancer, FOXM1, hTERT, ubiquitination, Wnt/β-catenin [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
Distribution and Toxicity of Submicron Plastic Particles in Mice
Environmental Toxicology and Pharmacology (Elsevier) Taiwan, 15 December 2022
Toxicology
Key words: Submicron microplastics, Oral gavage, Number concentration, Flow cytometry, Oxidative stress, Inflammation [more]
Organism: Mouse
Tissue: Lung
Synergistic cytotoxicity of perifosine and ABT‐737 to colon cancer cells
Journal of Cellular and Molecular Medicine (Wiley) Czech Republic, 15 December 2022
Oncology
Tissue: Spheroid
Cell Line: HT-29 and HCT-116 human adenocarcinoma cells
Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Austria, Germany, 10 December 2022
Immunology, Microbiology
Key words: Atherosclerosis, ICAM-1, Extracellular adherence protein, Neutrophils, NET [more]
Organism: Mouse
Tissue: Heart
Pathological State: Staphylococcus aureus Infection
Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells
Virologica Sinica (Elsevier) China, 10 December 2022
Virology
Key words: Myosin IIA (MYH9), Influenza A virus (IAV), vRNP activity, Virus-host interactions, Virus entry [more]
Cell Line: MDCK cells
A Proof-of-Concept Preclinical Study Using a Novel Thermal Insulation Device in a Porcine Kidney Auto-Transplantation Model
International Journal of Molecular Sciences (MDPI) Germany, Japan, 09 December 2022
Transplantation Medicine
Key words: kidney transplantation, organ insulation, ischemic reperfusion injury [more]
Organism: Pig
Tissue: Kidney
The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer's disease mouse model
Alzheimer's Research & Therapy (Springer) The Netherlands, 09 December 2022
Neuroscience
Key words: Alzheimer's disease, APP/PS1 mice, Hibernation-derived compound, SUL-138, Chromanols, Long-term potentiation, Hippocampus-dependent contextual fear memory, Amyloid-beta plaques, Mass-spectrometry, Mitochondria, Fatty acid metabolism [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer's disease
Angiotensin-converting enzyme 2 in human plasma and lung tissue
Blood Pressure (Taylor & Francis) China, 09 December 2022
Cardiology
Key words: ACE2, plasma, lung, tissue, hypertension
Fumarate hydratase inhibits non‑small cell lung cancer metastasis via inactivation of AMPK and upregulation of DAB2
Oncology Letters (Spandidos Publications) Taiwan, 09 December 2022
Oncology
Organism: Human
Tissue: Lung
Pathological State: Cancer
Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer
International Journal of Molecular Sciences (MDPI) Japan, USA, 08 December 2022
Oncology
Key words: drebrins, lymphocytes, tumor-infiltrating, lung neoplasms, tumor microenvironment, prognosis [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Effects of a Phytogenic Supplement Containing Olive By-Product and Green Tea Extracts on Growth Performance, Lipid Metabolism, and Hepatic Antioxidant Capacity in Largemouth Bass (Micropterus salmoides) Fed a High Soybean Meal Diet
Antioxidants (MDPI) China, Spain, 07 December 2022
Zoology
Key words: largemouth bass, soybean meal, phytogenic feed additive, antioxidant capacity, lipid metabolism [more]
Organism: Bass Fish
Tissue: Liver
Hybrid Transcytosis Nanopomegranates for Sensitizing Breast Cancer Radiotherapy in Deep Tumor Tissue
Nano Research (Scipen) China, 07 December 2022
Oncology
Key words: Breast cancer, transcytosis, hybrid nanopomegranate, hypoxia alleviation, radiosensitization [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
HMGB1 Promotes In Vitro and In Vivo Skeletal Muscle Atrophy through an IL-18-Dependent Mechanism
Cells (MDPI) Taiwan, 06 December 2022
Pharmacology
Key words: HMGB1, IL-18, inflammation, myogenesis, skeletal muscle atrophy [more]
Organism: Mouse
Tissue: Muscle
Role of Artificial Intelligence in Cancer Diagnosis and Drug Development
Combinatorial Chemistry & High Throughput Screening (Ingenta conect) , 02 December 2022
Oncology
Key words: Cancer, artificial intelligence, computational approach, deep learning, drug development, machine learning
Sex-based difference in response to recombinant human bone morphogenetic protein-2 in a rat posterolateral fusion model
Spine (Ingenta conect) USA, 01 December 2022
Key words: BMP, BMP-2, bone, healing, regeneration, rhBMP-2, sex, sex-dependent differences, spinal fusion, spine