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Visualize and assess phenotypes and spatial distribution across entire slides.
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Our modular and scalable whole slide imaging systems are built to evolve with your research, offering high image quality and precision.
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Use predefined pipelines and advanced image analysis options to tackle even the most complex research questions.
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Collaborate with a committed team of experts for tailored solutions, from pipeline optimization to unique customization.
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Explore complex datasets with integrated dimensionality reduction tools to uncover relationships and drive meaningful conclusions.
Explore Our Imaging and Analysis Solutions
"TissueFAXS and its analysis software deliver publication-quality imaging and robust data, empowering innovative research beyond classical image analysis."
"TissueFAXS enables state-of-the-art multiplex analysis of protein expression and tissue localization, making it my preferred tool for cancer research for over a decade."
"StrataQuest is a flexible and invaluable tool for analyzing the immune microenvironment in cancer research, perfectly tailored to our specific needs."
"Our TissueFAXS system has been indispensable since 2008, offering high-throughput imaging, precise cell quantification, and robust technical support, loved by all our users."
"TissueFAXS and StrataQuest have revolutionized our biocompatibility studies, offering unparalleled precision in imaging, quantification, and multiplex fluorescence microscopy."
"For 13 years, TissueFAXS has enabled groundbreaking discoveries in immune cell complexity, transforming our understanding of cancer pathomechanisms."
TissueFAXS revolutionized histopathology with AI-driven technology, supporting our vision to advance precision oncology in Africa."
Latest News and Events
The IF Cellular Microenvironment App allows to determine the cellular phenotype of specific IF-stained cell populations.
TG ACADEMY WEBINAR
Dr. Henning Ulrich
University of Sao Paulo
Our newest prodct Colubris, an All-in-one, platform for the acquisition, management, visualisation and analysis of imaging data is lauching soon!
In research, techniques like immuno-fluorescence staining combined with tissue cytometry are crucial for studying biology.
A recent study revealed important information on how cytolytic CD8+ T cells are central in determining long-term viral control.
Explore our online database of reference publications
Dr. Rupert Ecker, CEO of TissueGnostics, has achieved a remarkable milestone by gracing the cover of the World's Leader Magazine.
REDI Fellow Jyotsna Batra successfully completes her fellowship with TissueGnostics to battle prostate cancer.
Explore our analysis solutions in our Strataquest Appcenter and get inspired by the variety of applications.
Read What Our Customers Are Publishing
FEATURED PUBLICATION
Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.
FEATURED PUBLICATION
QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.
FEATURED PUBLICATION
To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.
FEATURED PUBLICATION
In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.
FEATURED PUBLICATION
Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.
FEATURED PUBLICATION
Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.
FEATURED PUBLICATION
Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.
FEATURED PUBLICATION
Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.
FEATURED PUBLICATION
Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.
FEATURED PUBLICATION
In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.
FEATURED PUBLICATION
In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.
FEATURED PUBLICATION
A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.
FEATURED PUBLICATION
Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.
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Cytometry encompasses several methods for investigating cells, such as their count, cell cycle state, phenotype, morphology, size ...
We have a lot of exciting plans to share for our big birthday, but we also have many important milestones to reflect on and remember...
The IHC Immune Status in Situ App uses the AI classifier to segment tissue into morphological entities such as tumor, stroma, and lymphocyte clusters. It further identifies single cells ...
Explore our online database of reference publications to find tout how tissue cytometry can elevate your research
Explore our vast catalog of analysis solutions in our Strataquest Appcenter and get inspired by the variety of applications.
Medical University
of Vienna
Read about tissue cytometry's potential in understanding the complexities of cell populations in the tissue environment
