Customer Publications (A total of 3040 papers published)

Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma

T Tashiro, K Imamura, Y Tomita, D Tamanoi, A Takaki, K Sugahara, R Sato, K Saruwatari, S Sakata, M Inaba, S Ushijima, N Hirata, T Sakagami

International Journal of Molecular Sciences (MDPI) Japan, USA, 19 December 2020

Oncology

Key words: Anaplastic Lymphoma Kinase (ALK), B Cell, Heterogeneity, Immune Checkpoint, Large Cell Neuroendocrine Carcinoma (LCNEC), Neuroendocrine Tumors (NET), Regulatory T-Cells (Tregs), Programmed Death-Ligand 1 (PD-L1), Tumor-Infiltrating Lymphocyte (TIL), Tumor-Immune Microenvironments (TIME) [more]

Parp1-Dependent DNA Double-Strand Break Repair in Irradiated Late Pachytene Spermatocytes

E A Ahmed, A M Alzahrani, H Scherthan

DNA and Cell Biology (Mary Ann Liebert Inc.) Saudi Arabia, Egypt, Germany, 18 December 2020

Reproductive Medicine

Key words: Alternative NHEJ, DNA Repair, First Meiotic Prophase, γ-H2AX, Homologous Recombination, Parp1, Spermatogenesis [more]

Differential mast cell phenotypes in benign versus cancer tissues and prostate cancer oncologic outcomes

H Hempel Sullivan, JP Maynard, CM Heaphy, J Lu, AM De Marzo, TL Lotan, CE Joshu, KS Sfanos

The Journal of Pathology (Wiley) USA, 18 December 2020

Oncology

Key words: Prostate Cancer, Mast Cells, Metastases, CXCR4, TFE3, KIT, Microenvironment [more]

ZFHX3 Knockdown Dysregulates Mitochondrial Adaptations to Tachypacing in Atrial Myocytes through Enhanced Oxidative Stress and Calcium Overload

B Lkhagva, YK Lin, YC Chen, WL Cheng, S Higa, YH

Acta Physiologica (Wiley) Taiwan, Japan, 17 December 2020

Physiology

Key words: Atrial Fibrillation, Calcium, Mitochondria, Tachypacing, ZFHX3 [more]

CD4+ CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum

H Allard-Chamard, F Alsufyani, N Kaneko, K Xing, C Perugino, VS Mahajan, JL Wheat, GS Deepe Jr, J Loyd and S Pillai

The Journal of Immunology (American Association of Immunologists) Canada, Saudi Arabia, Japan, USA, 16 December 2020

Immunology

[more]

Tribbles Pseudokinase 3 Contributes to Cancer Stemness of Endometrial Cancer Cells by Regulating β-Catenin Expression

WL Wang, GC Hong, PJ Chien, YH Huang, HT Lee, PH Wang, YC Lee, WW Chang

Cancers (MDPI) Taiwan, 15 December 2020

Oncology

Key words: Tribbles Pseudokinase 3, Endometrial Cancer, Cancer Stem Cells, β-Catenin, Epithelial–Mesenchymal Transition [more]

Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

TJ Hark, NR Rao, C Castillon, T Basta, S Smukowski, H Bao, A Upadhyay, E Bomba-Warczak, T Nomura, ET O'Toole, GP Morgan, L Ali, T Saito, C Guillermier, TC Saido, ML Steinhauser, MHB Stowell, ER Chapman, A Contractor, JN Savas

Cell Systems (Cell Press) USA, Japan, 15 December 2020

Neuroscience

Key words: Alzheimer's Diseasea, Myloid Beta, Synaptic Dysfunction, Presynapse, Synaptic Vesicles, Proteostasis, Mass Spectrometry, Proteomics, APP Knockin Mice [more]

Multicohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors

K Ando, A Ozonoff, SY Lee, M Viosine, JT Parker, R Nakanishi, S Nishimura, J Yang, Z Grace, B Tran, TJ Diefenbach, Y Maehara, H Yasui, T Irino, R Salgia, M Terashima, P Gibbs, RK Ramanathan, E Oki, M Mori, M Kulke, K Hartshorn, A Bharti

Clinical Colorectal Cancer (Elsevier) USA, Japan, Australia, 10 December 2020

Oncology

[more]

Spatiotemporal Up-Regulation of Mu Opioid Receptor 1 in Striatum of Mouse Model of Huntington's Disease Differentially Affecting Caudal and Striosomal Regions

R Morigaki, JH Lee, T Yoshida, C Wüthrich, D Hu, JR Crittenden, A Friedman, Y Kubota, AM Graybiel

Frontiers in Neuroanatomy (Frontiers Media S.A.) USA, Japan, 10 December 2020

Neuroscience

Key words: Mu Opioid Receptors, Huntington's Disease, Neostriatum, Movement Disorders, Mood Disorders, Animal Models of Human Disorders, Striosome [more]

Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro

L Elena Sima, A Bonciu, M Baciu, I Anghel, LN Dumitrescu, L Rusen, V Dinca

Nanomaterials (MDPI) Romania, 09 December 2020

Nanomedicine

Key words: Zirconia, Mesenchymal Stem Cells, Micro-Nano Topography, Osteogenic Differentiation, Bone-Anchored Hearing Aid (BAHA) [more]

The effect of dietary supplementation with high-or low-dose omega-3 fatty acid on inflammatory pathology after traumatic brain injury in rats

EK Black, JK Phillips, J Seminetta, J Bailes, JM Lee, JD Finan

Translational Neuroscience (degruyter) USA, 09 December 2020

Neuroscience

Key words: Dietary Supplementation, Docosahexanoic Acid, Eicosapentaenoic Acid, Neuroinflammation, Neuroprotection, Omega-3 Fatty Acid, Traumatic Brain Injury [more]

Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis

W Kang, Q Wang, Y Dai, H Wang, M Wang, J Wang, D Zhang, P Sun, T Qi, X Jin, Z Cui

Cell Death & Disease (Nature) China, 07 December 2020

Oncology

Key words: Bladder Cancer, Long Non-Coding RNAs, Oncogenesis [more]

Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients

H Wang, C Feng, M Lu, B Zhang, Y Xu, Q Zeng, J Xi, J Zhou, X Ying, J Zhang, W Yue, X Pei

Translational Oncology (Elsevier) China, 06 December 2020

Oncology

Key words: Liver Cancer, Single-Cell Transcriptome, Cancer-Distinct Fibroblast, SPARCL1 [more]

Lactic acidosis interferes with toxicity of perifosine to colorectal cancer spheroids: multimodal imaging analysis

B Pavlatovská, M Machálková, P Brisudová, A Pruška, K Štěpka, J Michálek, T Nečasová, P Beneš, J Šmarda, J Preisler, M Kozubek, J Navrátilová

Frontiers in Oncology (Frontiers Media S.A.) Czech Republic, Switzerland, China, 04 December 2020

Oncology

Key words: Perifosine, Akt Kinase, Tumor Environment, Lactic Acidosis, Alkalization, Signal Co-Registration, Mass Spectrometry Imaging, Colorectal Cancer [more]

AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

G Caluori, E Odehnalova, T Jadczyk, M Pesl, I Pavlova, L Valikova, S Holzinger, V Novotna, V Rotrekl, A Hampl, M Crha, D Cervinka, Z Starek

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) Czech Republic, France, Poland, Germany, 03 December 2020

Cardiology

Key words: Pulsed Field Ablation, Irreversible Electroporation (IRE), Radiofrequency Ablation, Atrial Fibrillation, Ventricular Arrhythmia (VA), Preclinical Cardiology [more]

Shear stress-exposed pulmonary artery endothelial cells fail to upregulate HSP70 in chronic thromboembolic pulmonary hypertension

W Salibe-Filho, TLS Araujo, EG Melo, LBCT Coimbra, MS Lapa, MMP Acencio, O Freitas-Filho, VL Capelozzi, LR Teixeira, CJCS Fernandes, F Biscegli Jatene, FRM Laurindo, M Terra-Filho

PLoS One (PLOS) Brazil, 03 December 2020

Cardiology

Key words: Shear Stresses, Endothelial Cells, Heat Shock Response, Pulmonary Arteries, Peas, Flow Cytometry, Nitric Oxide, Pulmonary Hypertension [more]

Infiltration of metastatic lymph nodes with PD-1+ T cells is associated with improved disease-free and overall survival in resected N+ NSCLC

S Wang, Y Song, MA Morse, P Sun, G Qiao, X Wang, X Zhou, A Hobeika, J Ren, HK Lyerly

American Journal of Cancer Research (e-Century Publishing Corporation) China, USA, 01 December 2020

Oncology

Key words: NSCLC, Metastatic Lymph Node, T Cell Subsets, PD-1, TIM-3 [more]

The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients

G Spanier, I Ugele, F Nieberle, L Symeou, S Schmidhofer, A Brand, J Meier, S Spoerl, R Krupar, P Rümmele, P Siska, K Renner, K Peter, M Gerken, P Beckhove, TE Reichert, M Kreutz, K Singer

Cancer Letters (Elsevier) Germany, 01 December 2020

Oncology

Key words: OSCC, Diabetes Mellitus, TIL, Metabolism, Prognosis [more]

p21‐activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1

H Huang, Q Xue, X Du, J Cui, J Wang, D Cheng, J Li, Y Zheng, G Huang, K Zhang, K Liu, J Lu, J Zhao, X Chen, Z Dong, X Li

Molecular Carcinogenesis (Wiley) China, 01 December 2020

Oncology

Key words: Cell Proliferation, Esophageal Squamous Cell Carcinoma, LASP1, Metastasis, PAK4 [more]

Cross-Reactive Effects of Vaccines: Heterologous Immunity between Tetanus and Chlamydia

M Stojanovic, I Lukic, E Marinkovic, A Kovacevic, R Miljkovic, J Tobias, I Schabussova, M Zlatovic, T Barisani-Asenbauer, U Wiedermann, A Inic-Kanada

Vaccines (MDPI) Serbia, Austria, 01 December 2020

Immunology

Key words: Vaccination, Heterologous Immunity, Antibodies, Tetanus, Chlamydia, Cross-Reactivity [more]

Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats

W Wang, X Liu, Z Yang, H Shen, L Liu, Y Yu, T Zhang

Frontiers in Neuroscience (Frontiers Media S.A.) China, 30 November 2020

Neuroscience

Key words: Levodopa, Hippocampus, Global Cerebral Ischemia Reperfusion Injury, Structural Synaptic Plasticity, Cognitive Function [more]

Characterization of epithelial cells, connective tissue cells and immune cells in human upper airway mucosa by immunofluorescence multichannel image cytometry: a pilot study

AI Giotakis, J Dudas, R Glueckert, D Dejaco, J Ingruber, F Fleischer, V innerhofer, L Pinggera, L Bektic-Tadic, SAM Gabriel, H Riechelmann

Histochemistry and Cell Biology (Springer) Austria, 29 November 2020

Medical Image Analysis

Key words: Image Cytometry, Fluorescent Antibody Technique, Immunohistochemistry, Nasal Mucosa, Sinusitis [more]

MicroRNA-146a suppresses tumor malignancy via targeting vimentin in esophageal squamous cell carcinoma cells with lower fibronectin membrane assembly

HY Chang, CH Lee, YS Li, JT Huang, SH Lan, YF Wang, WW Lai, YC Wang, YJ Lin, HS Liu, HC Cheng

Journal of Biomedical Science (BMC) Taiwan, 28 November 2020

Oncology

Key words: ESCC, MiR-146a, Vimentin, Cell Migration, Invasion [more]

Lactobacillus Attenuate the Progression of Pancreatic Cancer Promoted by Porphyromonas Gingivalis in K-rasG12D Transgenic Mice

SM Chen, LJ Hsu, HL Lee, CP Lin, SW Huang, CJL Lai, CW Lin, WT Chen, YJ Chen, YC Lin, CC Yang, MS Jan

Cancers (MDPI) Taiwan, 26 November 2020

Oncology

Key words: Caerulein, Lactobacillus, Pancreatic Ductal Adenocarcinoma, Porphyromonas Gingivalis, Transforming Growth Factor-β [more]

Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages

YY Wang, HD Chen, S Lo, YK Chen, YC Huang, S CS Hu, YC Hsieh, AC Hung, MF Hou, SS F Yuan

Cancers (MDPI) Taiwan, UK, 26 November 2020

Oncology

Key words: Visfatin, Breast Cancer, Tumor-Associated Macrophages, CXCL1 [more]

Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice

K Han, X Jin, X Guo, G Cao, S Tian, Y Song, Y Zuo, P Yu, G Gao, YZ Chang

Free Radical Biology and Medicine (Elsevier) China, 26 November 2020

Neuroscience

Key words: Nrf2, Motor Dysfunction, Brain Iron Metabolism, Oxidative Stress, FPN1 [more]

Neuropathology changed by 3-and 6-months low-level PM 2.5 inhalation exposure in spontaneously hypertensive rats

HC Chuang, HC Chen, PJ Chai, HT Liao, CF Wu, CL Chen, MK Jhan, HI Hsieh, KY Wu, TF Chen, TJ Cheng

Particle and Fibre Toxicology (Springer) Taiwan, 26 November 2020

Neuroscience

Key words: Air Pollution, Autophagy, Central Nervous System Toxicity, Particulate Matter, Tau [more]

Electric Pulse Responsive Magnetic Nanoclusters Loaded with Indoleamine 2, 3-Dioxygenase Inhibitor for Synergistic Immuno-Ablation Cancer Therapy

B Yu, W Zhang, K Kwak, H Choi, DH Kim

ACS Applied Materials & Interfaces (ACS Publications) USA, 25 November 2020

Oncology

Key words: Local Ablation, Irreversible Electroporation, Indoleamine 2, 3-Dioxygenase Inhibitor, Magnetic Nanoparticles, Immunotherapy [more]

Development of Rift valley fever encephalitis in rats is mediated by early infection of olfactory epithelium and neuroinvasion across the cribriform plate

DA Boyles, MM Schwarz, JR Albe, CM Mcmillen, KJ O'Malley, DS Reed, AL Hartman

Journal of General Virology (Microbiology Society) USA, 24 November 2020

Virology

Key words: Aerosol, Cribriform Plate, Encephalitis, Olfactory Bulb, Pathogenesis, Rift Valley Fever Virus [more]

Time-resolved analysis of Staphylococcus aureus invading the endothelial barrier

EJM Raineri, H Yedavally, A Salvati, JM van Dijl

Virulence (Taylor & Francis) The Netherlands, 22 November 2020

Microbiology

Key words: Staphylococcus Aureus, MRSA, Endothelium, Invasion, Intracellular [more]

Type II natural killer T cells contribute to protection against systemic methicillin-resistant Staphylococcus aureus infection

S Genardi, L Visvabharathy, L Cao, E Morgun, Y Cui, C Qi, YH Chen, L Gapin, E Berdyshev, CR Wang

Frontiers in Immunology (Frontiers Media S.A.) USA, 18 November 2020

Immunology

Key words: Staphylococcus Aureus, Natural Killer T Cells, CD1, Lipid Antigens, Cytokine, Knockout Mice [more]

Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease

J Strobl, RV Pandey, T Krausgruber, N Bayer, L Kleissl, B Reininger, P Vieyra-Garcia, P Wolf, MM Jentus, M Mitterbauer, W Rabitsch, G Stingl, C Bock, G Stray

Science Translational Medicine (AAAS) Austria, 18 November 2020

Dermatology

[more]

Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

A Li, Y Ling, Z Song, X Cheng, L Ding, R Jiang, W Fu, Y Liu, H Hu, S Yuan, J Chen, C Zhu, J Fan, J Wang, Y Jin, M Zhang, L Zhu, P Sun, L Zhang, R Qin, W Zhang, C Qiu, Y Shen, L Zhang, Z Shi, C Zhao, T Zhu, H Lu, H Zhang, J Xu

The Journal of Infectious Diseases (Oxford Academic) China, 17 November 2020

SARS-CoV-2

Key words: IL-37, SARS-CoV-2, COVID-19, Inflammation, Clinical Outcomes [more]

Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model

A Ramírez-Fernández, L Urbina-Treviño, G Conte, M Alves, B Rissiek, A Durner, N Scalbert, J Zhang, T Magnus, F Koch-Nolte, N Plesnila, JM Deussing, T Engel, R Kopp, A Nicke

Scientific Reports (Nature) Germany, Ireland, 16 November 2020

Neuroscience

Key words: Biological Techniques, Molecular Biology, Neuroscience [more]

HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age‐dependent changes

M Luque, A Schrott‐Fischer, J Dudas, E Pechriggl, E Brenner, H Rask-Andersen, W Liu, R Glueckert

Journal of Neuroscience Research (Wiley) Austria, 12 November 2020

Neuroscience

Key words: Auditory Development, Auditory Neuron Diversity, Axon Initial Segment, HCN Channels, Prestin, RRID:AB_90725, RRID:AB_2039906, RRID:AB_2302038, RRID:AB_2313584, RRID:AB_2313726, RRID:AB_2336419, RRID:AB_2336420, RRID:AB_2336790, RRID:AB_2340477, RRID:AB_2340452, RRID:AB_2340593, RRID:AB_2341028, RRID:AB_2617143, RRID:AB_2756625, RRID:AB_2756742, RRID:SCR_002865, RRID:SCR_013652, RRID:SCR_014823, Sound Coding, Spiral Ganglion Neurons, Voltage Gated [more]

Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

M Hara-Chikuma, M Tanaka, AS Verkman, M Yasui

Nature Communications (Nature) Japan, USA, 09 November 2020

Hepatology

Key words: Molecular Drug Discovery, Liver Diseases, Molecular Medicine [more]

CO2-Responsive Water-Soluble Conjugated Polymers for In Vitro and In Vivo Biological Imaging

CC Cheng, YC Lai, YT Shieh, YH Chang, AW Lee, JK Chen, DJ Lee, JY Lai

Biomacromolecules (ACS Publications) Taiwan, 06 November 2020

Bioimaging

[more]

Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19

Y Liu, J Lv, J Liu, M Li, J Xie, Q Lv, W Deng, N Zhou, Y Zhou, J Song, P Wang, C Qin, WM Tong, B Huang

Cell Research (Nature) China, 06 November 2020

Immunology, SARS-CoV-2

Key words: Immunology, Innate Immunity [more]

Evidence for a non-stochastic two-field hypothesis for persistent skin cancer risk

RL Konger, L Ren, RP Sahu, E Derr-Yellin, YL Kim

Scientific Reports (Nature) USA, 05 November 2020

Oncology

Key words: Cancer Microenvironment, Cancer Models, Skin Cancer, Squamous Cell Carcinoma [more]

Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14

R Widhalm, I Ellinger, S Granitzer, M Forsthuber, R Bajtela, K Gelles, PY Hartig, M Hengstschläger, H Zeisler, H Salzer, C Gundacker

Metallomics (Royal Society of Chemistry) Austria, 04 November 2020

Reproductive Medicine

[more]

Metformin chlorination byproducts in drinking water exhibit marked toxicities of a potential health concern

R Zhang, Y He, L Yao, J Chen, S Zhu, X Rao, P Tang, J You, G Hua, L Zhang, F Ju, L Wu

Environment International (Elsevier) China, 03 November 2020

Toxicology

Key words: Metformin, Metformin Chlorination Byproduct, Drinking Water, Toxicity, Public Health [more]

Effect of route of administration on the efficacy of dendritic cell vaccine in PDAC mice

J Yang, A Eresen, J Shangguan, Q Ma, Z Zhang, V Yaghmai

American Journal of Cancer Research (e-Century Publishing Corporation) USA, 01 November 2020

Oncology

Key words: Pancreatic Cancer, Dendritic Cell, Route of Administration [more]

Therapeutic Efficacy of GC1118, a Novel Anti-EGFR Antibody, against Glioblastoma with High EGFR Amplification in Patient-Derived Xenografts

K Lee, H Koo, Y Kim, D Kim, E Son, H Yang, Y Lim, M Hur, H Won Lee, S Won Choi, DH Nam

Cancers (MDPI) South Korea, 31 October 2020

Oncology

Key words: Glioblastoma, Epidermal Growth Factor Receptor, Monoclonal, Xenograft, Amplification [more]

P2Y2 receptor activation promotes esophageal cancer cells proliferation via ERK1/2 pathway

A Zaparte, AR Cappellari, CA Brandão, JB de Souza, TJ Borges, LW Kist, MR Bogo, LF Zerbini, LF Ribeiro Pinto, T Glaser, MCB Goncalves, Y Naaldijk, H Ulrich, FB Morrone

European Journal of Pharmacology (Elsevier) Brazil, USA, South Africa, 31 October 2020

Oncology

Key words: Esophageal Cancer, Purinergic System, Nucleotide, P2Y2R, Proliferation, Signaling Pathways [more]

Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia–reperfusion injury

R Wang, M Wang, J Zhou, Z Dai, G Sun, X Sun

Journal of Advanced Research (Elsevier) China, 31 October 2020

Cardiology

Key words: Calenduloside E, Myocardial Ischemia-Reperfusion Injury, L-Type Calcium Channelscalcium Overload, Bcl2-Associated Athanogene 3 [more]

B Cell Activating Factor (BAFF) Is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats

L Steines, H Poth, M Herrmann, A Schuster, B Banas, T Bergler

International Journal of Molecular Sciences (MDPI) Germany, 28 October 2020

Nephrology

Key words: Tertiary Lymphoid Organs, Kidney Transplantation, B Cells, BAFF [more]

Proteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model

RM Boteanu, VI Suica, L Ivan, F Safciuc, E Uyy, E Dragan, SM Croitoru, V Grumezescu, M Chiritoiu, LE Sima, C Vlagioiu, G Socol, F Antohe

Scientific Reports (Nature) Romania, 28 October 2020

Osteology

Key words: Bioinformatics, Biological Models, Fracture Repair, Immunological Techniques, Mass Spectrometry, Microscopy, Proteomic Analysis [more]

Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma

PL Yarova, P Huang, MW Schepelmann, R Bruce, R Ecker, R Nica, V Telezhkin, D Traini, L Gomes dos Reis, EJ Kidd, WR Ford, KJ Broadley, BM Kariuki, CJ Corrigan, JPT Ward, PJ Kemp, D Riccardi

The Journal of Pharmacology and Experimental Therapeutics (ASPET) UK, Austria, Australia, 28 October 2020

Pharmacology

[more]

Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model

A Friedman, E Hueske, SM Drammis, SET Arana, ED Nelson, CW Carter, S Delcasso, RX Rodriguez, H Lutwak, KS DiMarco, Q Zhang, LI Rakocevic, D Hu, JK Xiong, J Zhao, LG Gibb, T Yoshida, CA Siciliano, TJ Diefenbach, C Ramakrishnan, K Deisseroth, AM Graybiel

CELL (Cell Press) USA, 27 October 2020

Neuroscience

Key words: Corticostriatal, Approach-Avoidance, Cost-Benefit, Decision-Making, Utility, Subjective Value, Motivation, Parvalbumin Interneurons, VGluT1, Excitation-Inhibition Balance [more]

The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer

F Mungenast, A Meshcheryakova, A Beer, M Salzmann, D Tamandl, T Gruenberger, P Pietschmann, O Koperek, P Birner, I Kirsch, H Robins, M Mittlboeck, M Jaritz, M Bergmann, P Zimmermann, D Mechtcheriakova

Cancers (MDPI) Austria, Switzerland, 25 October 2020

Oncology

Key words: Lymphoid Structures,  Colonic Mucosa,  Metastatic Colorectal Cancer,  Immuno-Oncology,  B Lymphocytes,  Germinal Center,  Tissue Image Cytometry,  B-Cell Clonality,  Compendium-Wide Analysis,  Patient Stratification Strategy [more]

Cross‐section modified and highly elastic sutures reduce tissue incision and show comparable biocompatibility: in‐vitro and in‐vivo evaluation of novel thermoplastic urethane surgical threads

M Helmedag, D Heise, R Eickhoff, KM Kossel, T Gries, S Jockenhoevel, UP Neumann, CD Klink, A Lambertz

Journal of Biomedical Materials Research: Part B (Wiley) Germany, 24 October 2020

Tissue Engineering

Key words: Animal Trials, Biocompatibility, Elastic Sutures, Surface Modified Surgical Threads, Thermoplastic Polyurethane, Tissue Incision [more]

Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

N Jacob, K Kumagai, JP Abraham, Y Shimodaira, Y Ye, J Luu, AY Blackwood, SL Castanon, DT Stamps, LS Thomas, R Gonsky, DQ Shih, KS Michelsen, SR Targan

Scientific Reports (Nature) USA, 23 October 2020

Immunology, Gastroenterology

Key words: Cytokines, Gastroenterology, Immunology, Inflammation, Inflammatory Bowel Disease [more]

Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma

A Makarevic, C Rapp, S Dettling, D Reuss, C Jungk, A Abdollahi, A van Deimling, A Unterberg, C Herold-Mende, R Warta

International Journal of Molecular Sciences (MDPI) Germany, 21 October 2020

Neuroscience

Key words: Lower-Grade Glioma, T-Cell Infiltration, TissueFAXS, Primary Tumors, Recurrent Tumors, Radiotherapy [more]

Impaired autophagy increases susceptibility to endotoxin-induced chronic pancreatitis

L Xia, Z Xu, X Zhou, F Bergmann, N Grabe, MW Büchler, JP Neoptolemos, T Hackert, G Kroemer, F Fortunato

Cell Death & Disease (Nature) Germany, 21 October 2020

Gastroenterology

Key words: Acute Pancreatitis, Chronic Pancreatitis [more]

Tissue remodeling macrophages morphologically dominate at the interface of polypropylene surgical meshes in the human abdomen

A Dievernich, P Achenbach, L Davies, U Klinge

Hernia (Springer) Germany, UK, 18 October 2020

Tissue Engineering

Key words: Foreign Body Reaction, Macrophage, Collagen, Mesh, Fluorescence Microscopy [more]

CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy

Y Bei, N Cheng, T Chen, Y Shu, Y Yang, N Yang, X Zhou, B Liu, J Wie, Q Liu, W Zheng, W Zhang, H Su, WG Zhu, J Ji, P Shen

Advanced Science (Wiley) China, 15 October 2020

Oncology

Key words: Cancer Stem Cells, CD44 Variants, CDK5, Immune Checkpoint Blockade, PPARγ Phosphorylation, Triple‐Negative Breast Cancer, Tumor Microenvironment [more]

Poly (ADP-ribose) polymerase inhibitor treatment as a novel therapy attenuating renal ischemia-reperfusion injury

HR Jang, K Lee, J Jeon, JR Kim, JE Lee, GY Kwon, YG Kim, DJ Kim, JW Ko, W Huh

Frontiers in Immunology (Frontiers Media S.A.) South Korea, Italy, France, 14 October 2020

Immunology

Key words: Acute Kidney Injury, Ischemia-Reperfusion Injury, Poly(ADP-Ribose) Polymerase (PARP) Inhibitor, Parthanatos, Inflammation, Translational Immunology [more]

Two Polyurethane Adhesives for PVDF Fixation Show Superior Biocompatibility in a Rat Model

D Heise, Y Mirlas, M Helmedag, R Eickhoff, A Kroh, A Lambertz, CD Klink, UP Neumann, U Klinge, R Tolba

Journal of Investigative Surgery (Taylor & Francis) Germany, The Netherlands, 14 October 2020

Tissue Engineering

Key words: Mesh Fixation, Polyurethane Adhesive, Incisional Hernia [more]

FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

L Qiu, L Hu, H Wang, J Li, X Ruan, B Sun, J Zhi, X Zheng, L Gu, M Gao, P Kong, J Zhang

Cell Death & Disease (Nature) China, 09 October 2020

Oncology

Key words: Apoptosis, Macroautophagy [more]

Immune contexture analysis in immuno‐oncology: applications and challenges of multiplex fluorescent immunohistochemistry

R Shakya, TH Nguyen, N Waterhouse, R Khanna

Clinical & Translational Immunology (Wiley) Australia, 07 October 2020

Immunology

Key words: FCS Express Image Cytometry, Immune Profiling, Multiplexed Fluorescent Immunohistochemistry, Quantitative Digital Pathology, Tumor Microenvironment, Vectra

Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring: role for AREG-induced EGFR signaling

K Lkhagvadorj, Z Zeng, J Song, M Reinders-Luinge, W Kooistra, S Song, S Krauss-Etschmann, BN Melgert, J Cao, MN Hylkema

APSselect (American Physiological Society) The Netherlands, Mongolia, Germany, China, 06 October 2020

Pulmonology

Key words: Amphiregulin, Epithelial Cell Differentiation, Lung Organoids, Prenatal Smoke Exposure [more]

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency

M Werner-Klein, A Grujovic, C Irlbeck, M Obradović, M Hoffmann, H Koerkel-Qu, X Lu, S Treitschke, C Köstler, C Botteron, K Weidele, C Werno, B Polzer, S Kirsch, M Gužvić, J Warfsmann, K Honarnejad, Z Czyz, G Feliciello, I Blochberger, S Grunewald, E Schneider, G Haunschild, N Patwary, S Guetter, S Huber, B Rack, N Harbeck, S Buchholz, P Rümmele, N Heine, S Rose-John, CA Klein

Nature Communications (Nature) Germany, Switzerland, 05 October 2020

Oncology

Key words: Breast Cancer, Cancer [more]

Innovations present in the primate interneuron repertoire

FM Krienen, M Goldman, Q Zhang, RCH del Rosario, M Florio, R Machold, A Saunders, K Levandowski, H Zaniewski, B Schuman, C Wu, A Lutservitz, CD Mullally, N Reed, E Bien, L Bortolin, M Fernandez-Otero, JD Lin, A Wysoker, J Nemesh, D Kulp, M Burns, V Tkachev, R Smith, CA Walsh, J Dimidschstein, B Rudy, LS Kean, S Berretta, G Fishell, G Feng, SA McCarroll

Nature (Nature) USA, 30 September 2020

Neuroscience

Key words: Evolutionary Biology, Genetics of The Nervous System, Transcriptomics [more]

Peptide-Based TNF-α-Binding Decoy Therapy Mitigates Lipopolysaccharide-Induced Liver Injury in Mice

CY Chang, HJ Hsu, J Foo, HJ Shih, CJ Huang

Pharmaceuticals (MDPI) Taiwan, 29 September 2020

Hepatology

Key words: TNF-α, Necroptosis, Pyroptosis, Apoptosis, Autophagy, Mitochondrial Injury [more]

Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes

HT Wu, L Kang, YC Su, HY Ou, FY Chan, BH Su, YS Wang, CL Wu, AL Shiau, P Wu

Clinical Science (Portland Press) Taiwan, UK, 25 September 2020

Endocrinology

Key words: Fibrosis, Gestational Diabetes, Placenta, Prothymosin α, Trophoblast [more]

A Systemic Prime–Intrarectal Pull Strategy Raises Rectum-Resident CD8+ T Cells for Effective Protection in a Murine Model of LM-OVA Infection

Q He, L Jiang, K Cao, L Zhang, X Xie, S Zhang, X Ding, Y He, M Zhang, C Zhao, X Zhang, J Xu

Frontiers in Immunology (Frontiers Media S.A.) China, 24 September 2020

Immunology

Key words: Mucosal Immune Response, Rectum TRM, Prime–Pull Vaccination Strategy, HIV, Listeria Monocytogenes [more]

Discoidin Domain Receptors 1 Inhibition Alleviates Osteoarthritis via Enhancing Autophagy

HC Chou, CH Chen, LY Chou, TL Cheng, L Kang, SC Chuang, YS Lin, ML Ho, YH Wang, SY Lin, CZ Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 23 September 2020

Rheumatology

Key words: Discoidin Domain Receptors 1 (Ddr1), Osteoarthritis (OA), Autophagy, Apoptosis, Terminal Differentiation [more]

Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury

X Zhang, Y Jing, C Qin, C Liu, D Yang, F Gao, M Yang, L Du, J Li

Journal of Cellular and Molecular Medicine (Wiley) China, 17 September 2020

Neuroscience

Key words: Apoptosis, Autophagic Flux, Decompression, Mechanical Stress, mTOR, Spinal Cord Injury [more]

Two common polymorphic variants of OATP4A1 as potential risk factors for colorectal cancer

V Buxhofer‑Ausch, O Német, M Sheikh, H Andrikovics, A Reiner, C Ausch, D Mechtcheriakova, A Tordai, A Gleiss, C Özvegy‑laczka, W Jäger, T Thalhammer

Oncology Letters (Spandidos Publications) Austria, Hungary, 17 September 2020

Oncology

[more]

Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins through BIP

J Chen, Z Chen, M Liu, T Qiu, D Feng, C Zhao, S Zhang, X Zhang, J Xu

mBio (American Society for Microbiolgy) China, 15 September 2020

Virology

Key words: BIP, Placental Alkaline Phosphatase, Zika Virus, Placental Trophoblast Cells [more]

IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models

SW Lu, HC Pan, YH Hsu, KC Chang, LW Wu, WY Chen, MS Chang

Nature Communications (Nature) Taiwan, 14 September 2020

Oncology

Key words: Interleukins, Pancreatic Cancer [more]

In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP) 1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta

S Granitzer, I Ellinger, R Khan, K Gelles, R Widhalm, M Hengstschläger, H Zeisler, G Desoye, L Tupova, M Ceckova, H Salzer, C Gundacker

Archives of Toxicology (Springer) Austria, Czech Republic, 11 September 2020

Toxicology

Key words: Multidrug Resistance-Associated Protein 1, Methyl Mercury, HTR-8/Svneo, MDCKII, Oxidative Stress, Human Placenta [more]

The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix

S Taylor, M Whitfield, J Barratt, A Didangelos

The Journal of Immunology (American Association of Immnologists) UK, 11 September 2020

Immunology

[more]

Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury

S Lu, Y Tian, Y Luo, X Xu, W Ge, G Sun, X Sun

Journal of Advanced Research (Elsevier) China, 09 September 2020

Cardiology

Key words: Myocardial Ischemia-Reperfusion, Macrophage, Iminostilbene, Pyruvate Kinase M2 [more]

Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis

Z Guan, Z Chen, S Fu, L Dai, Y Shen

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China, 03 September 2020

Neuroscience

Key words: Alzheimer's Disease, Progranulin, Aβ, BACE1, Microglia [more]

Integrin VLA-4 as a PET imaging biomarker of hyper-adhesion in transgenic sickle mice

LA Perkins, L Nyiranshuti, L Little-Ihrig, JD Latoche, KE Day, Q Zhu, S Tavakoli, P Sundd, EM Novelli, CJ Anderson

Blood Advances (ASH Publications) USA, 03 September 2020

Cardiology

Key words: Adhesions, Biological Markers, Diagnostic Imaging, Integrins, Mice, Monoclonal Antibodies, Positron-Emission Tomography, Selectins, Flow Cytometry, Femur [more]

Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft

M Enayati, S Puchhammer, J Iturri, C Grasl, C Kaun, S Baudis, I Walter, H Schima, R Liska, J Wojta, JL Toca-Herrera, BK Podesser, H Bergmeister

Journal of the Mechanical Behavior of Biomedical Materials (Elsevier) Austria, 03 September 2020

Tissue Engineering

Key words: Biodegradation, Mechanical Stability, Macrophages, Thermoplastic Polyurethane, Cell Culture, Rat Model [more]

Murine induced pluripotent stem cell‐derived neuroimmune cell culture models emphasize opposite immune‐effector functions of interleukin 13‐primed microglia and macrophages in terms of neuroimmune toxicity

A Quarta, T Meese, Z Pieters, E Van Breedam, D Le Blon, J Van Broeckhoven, S Hendrix, H Goossens, N Hens, Z Berneman, F Van Nieuwerburgh, P Ponsaerts

GLIA (Wiley) Belgium, Germany, Spain, The Netherlands, 31 August 2020

Neuroscience

Key words: Bioluminescence Imaging, Interleukin 13, iPSC, Macrophages, Microglia, Neurotoxicity, Transcriptome [more]

The Secretome of Stressed Peripheral Blood Mononuclear Cells Increases Tissue Survival in a Rodent Epigastric Flap Model

S Hacker, R Mittermayr, D Traxler, C Keibl, A Resch, S Salminger, H Leiss, P Hacker, C Gabriel, B Golabi, R Pauzenberger, P Slezak, M Laggner, M Mildner, W Michlits, HJ Ankersmit

Bioengineering & Translational Medicine (Wiley) Austria, 30 August 2020

Tissue Engineering

Key words: Secretome, Angiogenesis, Flap Surgery, Necrosis Reconstructive Surgery, Tissue Regeneration [more]

Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential‐dependent NET‐formation

M Reithofer, J Karacs, J Strobl, C Kitzmüller, D Polak, K Seif, M Kamalov, CFW Becker, G Greiner, K Schmetterer

The FASEB Journal (Wiley) Austria, 29 August 2020

Cardiology

Key words: Aluminium Hydroxide, Vaccine, Adjuvant, Innate Response, Neutrophils, NET [more]

Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation

Y Zhou, M Yan, R Pan, Z Wang, X Tao, C Li, T Xia, X Liu, Q Chang

Journal of Ethnopharmacology (Elsevier) China, 28 August 2020

Neuroscience

Key words: Depression, Radix Polygalae, Chronic Restraint Stress, Autophagy, Neuroinflammation [more]

Topography-Mediated Myotube and Endothelial Alignment, Differentiation, and Extracellular Matrix Organization for Skeletal Muscle Engineering

AM Almonacid Suarez, MGL Brinker, LA Brouwer, I van der Ham, MC Harmsen, P van Rijn

Polymers (MDPI) The Netherlands, 28 August 2020

Tissue Engineering

Key words: Myoblasts, Topography, Vascularization, Endothelial Cells, Skeletal Muscle, Extracellular Matrix [more]

Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor

L Iamartino, T Elajnaf, K Gall, J David, T Manhardt, P Heffeter, M Grusch, S Derdak, S Baumgartner-Parzer, M Schepelmann, E Kallay

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (Elsevier) Austria, 27 August 2020

Oncology

Key words: Calcium-Sensing Receptor, Calcimimetic, Colorectal Cancer, Inflammation, Intestine [more]

The Effects of Skin Lesion Segmentation on the Performance of Dermatoscopic Image Classification

A Mahbod, P Tschandl, G Langs, R Ecker, I Ellinger

Computer Methods and Programs in Biomedicine (Elsevier) Austria, 26 August 2020

Medical Image Analysis

Key words: Skin Cancer, Dermatoscopy, Medical Image Analysis, Deep Learning, Effect of Segmentation on Classification

Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

JK Sa, N Chang, HW Lee, HJ Cho, M Ceccarelli, L Cerulo, J Yin, SS Kim, FP Caruso, M Lee, D Kim, YT Oh, Y Lee, NG Her, B Min, HJ Kim, DE Jeong, HM Kim, H Kim, S Chung, HG Woo, J Lee, DS Kong, HJ Seol, JI Lee, J Kim, WY Park, Q Wang, Erik P Sulman, AB Heimberger, M Lim, JB Park, A Iavarone, RGW Verhaak, DH Nam

Genome Biology (BMC) South Korea, Italy, China, USA, 26 August 2020

Oncology

[more]

Hindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption

R Gong, S Xu, A Hermundstad, Y Yu, SM Sternson

CELL (Cell Press) USA, 24 August 2020

Neuroscience

Key words: Hunger, Thirst, Palatability, Locus Coeruleus, Locus Ceruleus, periLC, Ingestive Behavior, Appetite, In Vivo Calcium Imaging, GRIN Lens [more]

Interruption of vascular endothelial growth factor receptor 2 signaling induces a proliferative pulmonary vasculopathy and pulmonary hypertension

MP Winter, S Sharma, J Altmann, V Seidl, A Panzenböck, A Alimohammadi, T Zelniker, B Redwan, F Nagel, D Santer, A Stieglbauer, B Podesser, M Sibilia, T Helbich, G Prager, A Ilhan-Mutlu, M Preusser, IM Lang

Basic Research in Cardiology (Springer) Austria, Germany, 23 August 2020

Pulmonology

Key words: Pulmonary Hypertension, VEGFR-2, FLK, Kdr, Murine Model [more]

Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19

N Kaneko, HH Kuo, J Boucau, JR Farmer, H Allard-Chamard, VS Mahajan, A Piechocka-Trocha, K Lefteri, M Osborn, J Bals, YC Bartsch, N Bonheur, TM Caradonna, J Chevalier, F Chowdhury, TJ Diefenbach, K Einkauf, J Fallon, J Feldman, KK Finn, P Garcia-Broncano, C Adijaya Hartana, BM Hauser, C Jiang, P Kaplonek, M Karpell, EC Koscher, X Lian, H Liu, J Liu, NL Ly, AR Michell, Y Rassadkina, K Seiger, L Sessa, S Shin, N Singh, W Sun, X Sun, HJ Ticheli, MT Waring, AL Zhu, G Alter, JZ Li, D Lingwood, AG Schmidt, M Lichterfeld, BD Walker, XG Yu, RF Padera Jr, S Pillai

CELL (Cell Press) USA, Canada, 19 August 2020

SARS-CoV-2

Key words: SARS-CoV-2, COVID-19, T Follicular Helper Cells, Germinal Centers, Double-Negative B Cells, Extra-Follicular B Cells, Plasmablasts, Humoral Immunity, TNF-α, Cytokine Dysregulation [more]

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

R Vatapalli, V Sagar, Y Rodriguez, JC Zhao, K Unno, S Pamarthy, B Lysy, J Anker, H Han, YA Yoo, M Truica, ZR Chalmers, F Giles, J Yu, D Chakravarti, B Carneiro, SA Abdulkadir

Nature Communications (Nature) USA, 19 August 2020

Oncology

Key words: Epigenomics, Prostate Cancer, Targeted Therapies [more]

Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer

V Stary, B Wolf, D Unterleuthner, J List, M Talic, J Längle, A Beer, J Strobl, G Stary, H Dolznig, M Bergman

Journal for ImmunoTherapy of Cancer (BMJ Journals) Austria, 18 August 2020

Oncology

Key words: Macrophages, Radiotherapy, Tumor Microenvironment [more]

Epithelial cell–specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice

HC Do-Umehara, C Chen, Q Zhang, AV Misharin, H Abdala-Valencia, SM Casalino-Matsuda, PA Reyfman, KR Anekalla, FJ Gonzalez-Gonzalez, MA Sala, C Peng, P Wu, CCL Wong, R Kalhan, A Bharat, H Perlman, KM Ridge, JI Sznajder, PHS Sporn, NS Chandel, J Yu, X Fu, I Petrache, R Tuder, GRS Budinger, J Liu

Science Advances (AAAS) USA, China, 14 August 2020

Immunology

[more]

Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring-Role for AREG-induced EGFR signaling.

K Lkhagvadorj, Z Zeng, J Song, M Reinders-Luinge, W Kooistra, S Song

American Journal of Physiology (APS Journals) The Netherlands, China, 12 August 2020

Pulmonology

Key words: Prenatal Smoke Exposure, Epithelial Cell Differentiation, Amphiregulin, Lung Organoids [more]

Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression

CC Lin, IY Kuo, LT Wu, WH Kuan, SY Liao, J Jen, YE Yang, CW Tang, YR Chen, YC Wang

Theranostics (Ivyspring International Publisher) Taiwan, 08 August 2020

Oncology

Key words: Lung Cancer, Kras, Shh, Transcription, Angiogenesis [more]

The effects of CYP24A1 on clinicopathological features and the prognosis of pancreatic ductal adenocarcinoma

W Gao, TF Wang, W Yi, WM Tong

Translational Cancer Research (AME Publishing Company) China, 08 August 2020

Oncology

Key words: CYP24A1, Pancreatic Cancer, Prognosis [more]

Human FBXL8 Is a Novel E3 Ligase Which Promotes BRCA Metastasis by Stimulating Pro-Tumorigenic Cytokines and Inhibiting Tumor Suppressors

SC Chang, W Hsu, ECY Su, CS Hung, JL Ding

Cancers (MDPI) Taiwan, Singapore, 07 August 2020

Oncology

Key words: FBXL8 SCF E3 Ubiquitin Ligase, CCND2, IRF5, Breast Cancer (BRCA) And Metastasis, Pro-Tumorigenic Microenvironment [more]

Pyramidal shaped ceria nano-biointerfaces for studying the early bone cell response

AF Bonciu, S Orobeti, LE Sima, M Icriverzi, M Filipescu, A Moldovan, A Popescu, V Dinca, M Dinescu

Applied Surface Science (Elsevier) Romania, 06 August 2020

Biomaterials

Key words: Pyramidal Shaped Ceria Nano-Biointerfaces, PLD, Cells Response [more]

Sodium Cholate Bile Acid-Stabilized Ferumoxytol-Doxorubicin-Lipiodol Emulsion for Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

K Kwak, B Yu, SK Mouli, AC Larson, DH Kim

Journal of Vascular and Interventional Radiology (Elsevier) USA, 06 August 2020

Oncology

[more]

Light‐emitting diode irradiation induces AKT/mTOR‐mediated apoptosis in human pancreatic cancer cells and xenograft mouse model

YM Kim, SH Ko, YI Shin, Y Kim, T Kim, J Jung, SY Lee, NG Kim, KJ Park, JH Ryu

Journal of Cellular Physiology (Wiley Online Library) South Korea, 04 August 2020

Oncology

Key words: AKT/mTOR Pathway, Apoptosis, LED Irradiation, Pancreatic Cancer, Tumor Growth [more]

Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

M Srivastava, Y Zhang, J Chen, D Sirohi, A Miller, Y Zhang, Z Chen, H Lu, J Xu, RJ Kuhn, WA Tao

Nature Communications (Nature) USA, China, 04 August 2020

Virology

Key words: Chemical Tools, Proteomics, Virus–Host Interactions [more]

Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes

YJ Huang, TH Huang, VK Yadav, M Rachmawati Sumitra, DTW Tzeng, PL Wie, JW Shih, ATH Wu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, China, 01 August 2020

Oncology

Key words: Colon Cancer Stem Cells, Tumor Microenvironment, 5-FU Resistance, Tumorsphere Derived Exosomes, Β-Catenin/STAT3/MiR-1246 Signaling, Ovatodiolide [more]

Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells

A Yawer, E Sychrová, P Labohá, J Raška, T Jambor, P Babica, I Sovadinová

Toxicology and Applied Pharmacology (Elsevier) Czech Republic, Slovakia, 31 July 2020

Endocrinology

Key words: Connexins, Endocrine-Disrupting Chemicals, Gap Junctional Intercellular Communication, Leydig Cells, Reproductive Toxicants, Steroidogenesis [more]

A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model

IJ Su, HY Chang, HC Wang, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan, 30 July 2020

Neuroscience

Key words: Alzheimer's Disease Therapy, Curcumin Analog, TML-6, Aging, Bioavailability [more]

Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin

L Molcan, A Maier, A Zemančíková, K Gelles, J Török, M Zeman, I Ellinger

Cellular and Molecular Neurobiology (Springer) Slovakia, Austria, 30 July 2020

Cardiology

Key words: Rat Melatonin Receptor MT1, Melatonin, Mesenteric Artery (MA), Perivascular Fat Tissue (PVAT), Neurogenic Contraction [more]

Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy

J Ye, S Lu, M Wang, W Ge, H Liu, Y Qi, J Fu, Q Zhang, B Zhang, G Sun, X Sun

Frontiers in Pharmacology (Frontiers Media S.A.) China, 30 July 2020

Cardiology

Key words: Myocardial Ischemia Reperfusion Injury, Hydroxysafflor Yellow A, NLRP3, Autophagy, AMPK [more]

NHF-derived carbon dots: prevalidation approach in breast cancer treatment

CE Tiron, G Luta, M Butura, F Zugun-Eloae, CS Stan, A Coroaba, EL Ursu, G Dumitrita Stanciu, A Tiron

Scientific Reports (Nature) Romania, 29 July 2020

Oncology

Key words: Cancer, Drug Development, Medical Research, Oncology, Preclinical Research, Translational Research [more]

BMI1-Mediated Pemetrexed Resistance in Non-Small Cell Lung Cancer Cells Is Associated with Increased SP1 Activation and Cancer Stemness

HT Shen, PJ Chien, SH Chen, GT Sheu, MS Jan, BY Wang, WW Chang

Cancers (MDPI) Taiwan, 27 July 2020

Oncology

Key words: BMI1, SP1, Pemetrexed Resistance, Non Small Cell Lung Cancer, Cancer Stem Cells, Epithelial–Mesenchymal Transition [more]

A general method to optimize and functionalize red-shifted rhodamine dyes

JB Grimm, AN Tkachuk, L Xie, H Choi, B Mohar, N Falco, K Schaefer, R Patel, Q Zheng, Z Liu, J Lippincott-Schwartz, TA Brown, LD Lavis

Nature Methods (Nature) USA, 27 July 2020

Biological Methods

Key words: Chemical Biology, Chemical Tools, Fluorescence Imaging, Imaging [more]

Ready to go 3D? A semi-automated protocol for microwell spheroid arrays to increase scalability and throughput of 3D cell culture testing

A Basu, A Dydowiczová, JE Trosko, L Bláha, P Babica

Toxicology Mechanisms and Methods (Taylor & Francis) Czech Republic, USA, 26 July 2020

Biological Methods

[more]

Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents–Implications for oxidative UV damage

C Kremslehner, A Miller, R Nica, IM Nagelreiter, MS Narzt, B Golabi, V Vorstandlechner, M Mildner, J Lachner, E Tschachler, F Ferrara, K Klavins, M Schlosserer, J Grillari, A Haschemi, F Gruber

Redox Biology (Elsevier) Austria, Italy, USA, 19 July 2020

Dermatology

[more]

Enterocyte-Based Bioassay via Quantitative Combination of Proinflammatory Sentinels Specific to 8-keto-trichothecenes

SH Park, Y Moon

Frontiers in Immunology (Frontiers Media S.A.) South Korea, 16 July 2020

Immunology

Key words: 8-Keto-Trichothecene, Ribotoxic Stress, Inflammation, Epithelium, Reporter Biomonitoring [more]

Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets

P Haider, JB Kral-Pointner, J Mayer, M Richter, C Kaun, C Brostjan, W Ellenberg, MB Fischer, WS Spledl, C Hengstenberg, K Huber, J Wojta, P Hohensinner

Arteriosclerosis, Thrombosis and Vascular Biology (American Heart Association) Austria, 16 July 2020

Cardiology

Key words: Aortic Aneurysm, Extracellular Traps, Humans, Macrophages, Thrombosis [more]

Pre-and post-irradiation mild hyperthermia enabled by NIR-II for sensitizing radiotherapy

Q Li, L Hang, W Jiang, J Dou, L Xiao, X Tang, Y Yao, Y Wang

Biomaterials (Elsevier) China, 14 July 2020

Biomaterials

Key words: Au Nanobipyramids, Second Near-Infrared Window, Mild Hyperthermia, Radiotherapy [more]

Antidiabetic activity in vitro and in vivo of BDB, protein tyrosine phosphatase 1B selective inhibitor from Rhodonela conferviodes

J Luo, M Zheng, B Jiang, C Li, S Guo, L Wang, X Li, R Yu, D Shi

British Journal of Pharmacology (Wiley) China, 14 July 2020

Pharmacology

Key words: Bromophenol, PTP1B Inhibitor, Selectivity, Cell Permeability, Oral Bioavailability [more]

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

D Dems, R Freeman, T Coradin, SI Stupp, C Aime

Acta Biomaterialia (SSRN) France, USA, 13 July 2020

Biomaterials

Key words: Peptide Amphiphile, Silica Particles, Nanobiocomposites, Hybrid Biomaterials, Clustering [more]

Lycopene Inhibit IMQ-Induced Psoriasis-Like Inflammation by Inhibiting ICAM-1 Production in Mice

CM Shih, CK Hsieh, CY Huang, CY Huang, KH Wang, TH Fong, NTT Trang, KT Liu, AW Lee

Polymers (MDPI) Taiwan, 09 July 2020

Dermatology

Key words: Lycopene, Psoriasis [more]

Using Cytometry for Investigation of Purinergic Signaling in Tumor‐Associated Macrophages

VF Arnaud‐Sampaio, ILA Rabelo, CA Bento, T Glaser, J Bezerra, R Coutinho-Silva, H Ulrich, C Lameu

Cytometry Part A (Wiley) Brazil, 07 July 2020

Oncology

Key words: Macrophage, TAM, Cancer Stem Cells, Purines, ATP, Purinergic System, EMT, Image Cytometry [more]

Multimodal single‐cell analysis reveals distinct radioresistant stem‐like and progenitor cell populations in murine glioma

J Alexander, QC LaPlant, SS Pattwell, F Szulzewsky, PJ Cimino, FP Caruso, P Pugliese, Z Chen, F Chardon, AJ Hill, C Spurrell, D Ahrendsen, A Pietras, LM Starita, D Hambardzumyan, A Iavarone, J Shendure, EC Holland

GLIA (Wiley) USA, Italy, Sweden, 04 July 2020

Neuroscience

Key words: Glioma, Glioma Stem Cells, Myeloid Cells, Radiation Response, Radioresistance, Single‐Cell RNA Sequencing, SP Analysis [more]

Catching Common Cold Virus with a Net: Pyridostatin Forms Filaments in Tris Buffer That Trap Viruses—A Novel Antiviral Strategy?

A Real-Hohn, R Zhu, H Ganjian, N Ibrahim, P Hinterdorfer, H Kowalski, D Blaas

Viruses (MDPI) Austria, Sweden, 04 July 2020

Virology

Key words: Enterovirus, Rhinovirus, Pyridostatin, Filament, Extracellular Traps [more]

Fewer tumour-specific PD-1+ CD8+ TILs in high-risk “Infiltrating” HPV− HNSCC

K Xu, Y Fu, Y Han, R Xia, S Xu, S Duan, Z Zhang, J Li

British Journal of Cancer (Nature) China, 03 July 2020

Oncology

Key words: Head and Neck Cancer, Tumour Immunology [more]

Slug Is A Surrogate Marker of Epithelial to Mesenchymal Transition (EMT) in Head and Neck Cancer

TB Steinbichler, J Dudas, J Ingruber, R Glueckert, S Sprung, F Fleischer, N Cidlinsky, D Dejaco, B Kofler, AI Giotakis, II Skvortsova, H Riechelmann

Journal of Clinical Medicine (MDPI) Austria, 30 June 2020

Oncology

Key words: Image Cytometry, p16, p53, Cancer Stem Cells, E-Cadherin, β -Catenin, EMT, Head and Neck Cancer [more]

Functional characterization of the basal amygdala-dorsal BNST pathway during contextual fear conditioning

JS Russell, S Trouche, LG Reijmers

eNeuro (Society for Neuroscience) USA, 29 June 2020

Neuroscience

Key words: Contextual Fear, Fear Memorybasal Amygdala, Bed Nucleus of The Stria Terminalis, Neural Circuits, Encoding, Fear Engram [more]

Tissues derived from reprogrammed Wharton's jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus

CM Kong, A Subramanian, SU Gan, A Biswas, B Ariff, CY Fong

Stem Cell Research (Elsevier) Singapore, 26 June 2020

Stem Cell Research

Key words: Gestational Diabetes Mellitus, Induced Pluripotent Stem Cells, Reprogramming, Wharton's Jelly Stem Cells, Pancreatic Cells [more]

Comparison between paramagnetic and CD71 magnetic activated cell sorting of fetal nucleated red blood cells from the maternal blood

D Nemescu, D Constantinescu, V Gorduza, A Carauleanu, L Caba, DB Navolan

Journal of Clinical Laboratory Analysis (Wiley) Romania, 25 June 2020

Biological Methods

Key words: CD71, Fluorescent in Situ Hybridization, Magnetic‐Activated Cell Sorting, Nucleated Red Blood Cells, Prenatal Diagnosis [more]

BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer

YC Hsu, CW Luo, WL Huang, CC Wu, CL Chou, CI Chen, SJ Chang, CY Chai, HC Wang, TY Chen, CF Li, MR Pan

Radiotherapy and Oncology (Elsevier) Taiwan, 24 June 2020

Radiotherapy, Oncology

Key words: BMI1, CCRT, Rectal Cancers, Radioresistance [more]

The chemokine lymphotactin and its recombinant variants in oral cancer cell regulation

AZ Abdullah Zubir, SA Whawell, TS Wong, SA Khurram

Oral Diseases (Wiley) UK, 19 June 2020

Oncology

Key words: Cancer‐Associated Fibroblast, Lymphotactin, Oral Squamous Cell Carcinoma, Tumour Microenvironment, XCR1 [more]

p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection

H Ishida, A Kasajima, F Fujishima, R Akaishi, S Ueki, Y Yamazaki, Y Onodera, X Gao, H Okamoto, Y Taniyama, T Kanei, H Sasano

Virchows Archiv (Springer) Japan, Australia, Germany, 16 June 2020

Oncology

Key words: Esophagus, Small-Cell Carcinoma, Poorly Differentiated Squamous Cell Carcinoma, Basaloid Squamous Cell Carcinoma, P16, Human Papillomavirus [more]

Reciprocal Regulation Between Indoleamine 2, 3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells

HY Low, YC Lee, YJ Lee, HL Wang, YI Chen, PJ Chien, ST Li, WW Chang

Cancers (MDPI) Taiwan, 12 June 2020

Oncology, Stem Cell Research

Key words: IDO1, Notch1, Radiation, Cervical Cancer, Cancer Stem Cells [more]

Tumor Microenvironment Targeting Nano–Bio Emulsion for Synergistic Combinational X‐Ray PDT with Oncolytic Bacteria Therapy

W Park, S Cho, D Kang, JH Han, JH Park, B Lee, J Lee, DH Kim

Advanced Healthcare Materials (Wiley) South Korea, USA, 11 June 2020

Oncology, Nanomedicine

Key words: Bacteriolytic Therapy, Nano–Bio Emulsions, Scintillating Nanoparticles, Tumor Microenvironments, X‐Ray Photodynamic Therapy (PDT) [more]

Regulatory T cells promote adipocyte beiging in subcutaneous adipose tissue

W Fang, Z Deng, F Benadjaoud, D Yang C Yang, GP Shi

The FASEB Journal (Wiley) USA, China, 08 June 2020

Immunology

Key words: Epididymal White Adipose Tissue, Gonadal White Adipose Tissue, Macrophage Polarization, Regulatory T Cell, Subcutaneous Adipose Tissue, Uncoupling Protein‐1

Yttrium-90 Radioembolization and Tumor Hypoxia: Gas-challenge BOLD Imaging in the VX2 Rabbit Model of Hepatocellular Carcinoma

AC Gordon, SB White, VL Gates, D Procissi, KR Harris, Y Yang, Z Zhang, W Li, T Lyu, X Huang, RA Omary, R Salem, RJ Lewandowski, AC Larson

Academic Radiology (Elsevier) USA, 07 June 2020

Radiotherapy, Oncology

Key words: Oxygenation, Hepatic Radioembolization, Magnetic Resonance Imaging, Yttrium-90 [more]

A prominent environmental endocrine disruptor, 4-nonylphenol, promotes endometriosis development via plasmacytoid dendritic cells

P Sharma, HH Tzeng, JYL Lee, EM Tsai, JL Suen

Molecular Human Reproduction (Oxford Academic) Taiwan, 04 June 2020

Reproductive Medicine

Key words: CD36, Endometriosis, Environmental Endocrine Disruptor, Estrous Cycle, IL-10, 4-Nonylphenol, Plasmacytoid Dendritic Cell [more]

A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure

H Shawer, E Aiyelaagbe, C Clowes, SC Lean, Y Lu, KE Kadler, A Kerby, MR Dilworth, KE Hentges, AEP Heazell

PLoS One (PLOS) UK, 03 June 2020

Reproductive Medicine

Key words: Mouse Models, Stillbirths, Embryos, Placenta, Fetal Death, Myocardium, Heart, Giant Cells [more]

GPRC5A reduction contributes to pollutant benzo [a] pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients

Z Huang, S Wang, Y Liu, L Fan, Y Zeng, H Han, H Zhang, X Yu, Y Zhang, D Huang, Y Wu, W Jiang, P Zhu, X Zhu, X Yi

Science of The Total Environment (Elsevier) China, 03 June 2020

Toxicology

Key words: Pulmonary Fibrosis, GPRC5A, Benzo[A]Pyrene Pollution, Epithelium, Prognosis [more]

AB0154 MERTK AND THE RESOLUTION OF INFLAMMATION IN IGG4-RELATED DISEASE

E Della Torre, L Rovati, A Monno, T Maehara, N Kaneko, M Lanzillotta, F Pedica, C Doglioni, S Pillai, A Manfredi

Annals of the Rheumatic Diseases (BMJ Journals) Italy, Japan, USA, 02 June 2020

Immunology

[more]

Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer

CS Lu, AL Shiau, BH Su, TS Hsu, CT Wang, YC Su, MS Tsai, YH Feng, YL Tseng, YT Yen, CL Wu, GS Shieh

Journal of Hematology & Oncology (Springer) Taiwan, 01 June 2020

Oncology

Key words: Lung Cancer, Oct4, M2 Macrophage, Tumor-Associated Macrophage, M-CSF [more]

CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining

U Klinge, A Dievernich, R Tolba, B Klosterhalfen, L Davies

Journal of Biomedical Materials Research: Part B (Wiley) Germany, UK, 30 May 2020

Biomaterials

Key words: Fluorescence Microscopy, Foreign Body Reaction, Lymphocyte, Macrophage, Mesh [more]

CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease

Cory A Perugino, Naoki Kaneko, Takashi Maehara, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S Mahajan, Hang Liu, Emanuel Della-Torre, Samuel J H Murphy, Musie Ghebremichael, Zachary S Wallace, Marcy B Bolster, Liam M Harvey, Geetha Mylvaganam, Yesim Tuncay, Lloyd Liang, Sydney B Montesi, Xiuwei Zhang, Akira Tinju, Keita Mochizuki, Ryusuke Munemura, Mizuki Sakamoto, Masafumi Moriyama, Seiji Nakamura, Nir Yosef, John H Stone, Shiv Pillai

Journal of Allergy and Clinical Immunology (Mosby) USA, Japan, The Netherlands, Canada, China, Italy, 29 May 2020

Immunology

Key words: IgG4-RD, CD4+CTL, CD8+CTL, Apoptosis, CD28lo, CD28(Null) [more]

Caveolar communication with xenobiotic-stalled ribosomes compromises gut barrier integrity

SH Park, J Kim, Y Moon

Communications Biology (Nature) South Korea, 27 May 2020

Gastroenterology

Key words: Biomarkers, Cell Biology, Chemokines, Inflammation, Signal Transduction [more]

Interaction of different cell types with magnesium modified by plasma electrolytic oxidation

M Echeverry-Rendon, F Echeverria, MC Harmsen

Colloids and Surfaces B: Biointerfaces (Elsevier) Colombia, The Netherlands, 26 May 2020

Biomaterials

Key words: Magnesium, PEO, Adipose-Derived Stromal, ASC, Differentiation, Cytotoxicity [more]

Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way

T Niedermair, S Schirner, RH Straub, S Grässel

Mechanisms of Ageing and  Development (Elsevier) Germany, 22 May 2020

Osteology

Key words: Bone, Osteoblast, Osteoclast, α -Calcitonin Gene-Related Peptide (α -CGRP), Osteopenia [more]

KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation

RAF Gjaltema, D Goubert, C Huisman, C del Pilar Garcia Tobilla, M Koncz, PG Jellema, D Wu, U Brouwer, A Kiss, PJ Verschure, RA Bank, MG Rots

International Journal of Molecular Sciences (MDPI) The Netherlands, Hungary, 21 May 2020

Oncology

Key words: Pigenetic Editing, KRAB, Gene Repression, PLOD2, Fibrosis, Cancer [more]

Synergistic effect of cell-derived extracellular matrix and topography on osteogenesis of mesenchymal stem cells

L Yang, L Ge, P van Rijn

ACS Applied Materials & Interfaces (ACS Publications) The Netherlands, 18 May 2020

Tissue Engineering

Key words: Extracellular Matrix, Topography, Mesenchymal Stem Cells, Osteogenic Differentiation, Mechanotransduction [more]

Biomimetic Multiscale Hierarchical Topography Enhances Osteogenic Differentiation of Human Mesenchymal Stem Cells

L Yang, L Ge, Q Zhou, T Mokabber, Y Pei, R Bron, P van Rijn

Advanced Materials Interfaces (Wiley) The Netherlands, China, 13 May 2020

Stem Cell Research

Key words: Collagen, Extracellular Matrix, Hierarchical Topography, Human Mesenchymal Stem Cells, Mechanotransduction, Osteogenic Differentiation [more]

Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome

Kim L Brunekreeft, Sterre T Paijens, Maartje CA Wouters, Fenne L Komdeur, Florine A Eggink, Joyce M Lubbers, Hagma H Workel, Elisabeth C Van Der Slikke, Noor EJ Pröpper, Ninke Leffers, Julien Adam, Harry Pijper, Annechien Plat, Arjan Kol, Hans W Nijman, Marco De Bruyn

OncoImmunology (Taylor & Francis) The Netherlands, France, Canada, 13 May 2020

Oncology, Immunology

Key words: Epithelial Ovarian Cancer, Chemotherapy, Tumor Microenvironment, Cancer Immunology, MHC-I [more]

Progesteron receptor expression in insulin producing cells of neuroendocrine neoplasms

T Tachibana, A Kasajima, T Aoki, T Tabata, K McNamara, S Yazdani, S Satoko, F Fujishima, F Motoi, M Unno, H Sasano

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Japan, Germany, 11 May 2020

Endocrinology

Key words: Neuroendocrine Neoplasm, Insulinoma, Progesteron Receptor [more]

Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program

M Granai, L Mundo, AU Akarca, MC Siciliano, H Rizvi, V Mancini, N Onyango, J Nyagol, NO Abinya, I Maha, S Margielewska, W Wi, M Bibas, PP Piccaluga, L Quintanilla-Martinez, F Fend, S Lazzi, L Leoncini, T Marafioti

Infectious Agents and Cancer (BMC) Italy, Germany, UK, Kenya, Egypt,, 06 May 2020

Oncology, Virology

Key words: Burkitt Lymphoma, Tumour Microenvironment, EBV, PD-L1, Immunotherapy, Immune Checkpoint [more]

Decoupling the Amplitude and Wavelength of Anisotropic Topography and the Influence on Osteogenic Differentiation of Mesenchymal Stem Cells Using a High-Throughput Screening Approach

L Yang, L Ge, Q Zhou, K Jurczak, P van Rijn

ACS Applied Bio Materials (ACS Publications) The Netherlands, China, 06 May 2020

Stem Cell Research

[more]

High‐Throughput Screening and Hierarchical Topography‐Mediated Neural Differentiation of Mesenchymal Stem Cells

L Yang, KM Jurczak, L Ge, P van Rijn

Advanced Healthcare Materials (Wiley Online Library) The Netherlands, 04 May 2020

Stem Cell Research

Key words: Anisotropic Topography, Hierarchical Structures, High‐Throughput Screening, Human Mesenchymal Stem Cells, Neural Differentiation [more]

The Prognostic and Predictive Value of SOX2+ Cell Densities in Patients Treated for Colorectal Cancer

TJ Miller, MJ McCoy, TF Lee-Pullen, CC Anyaegbu, C Hemmings, MK Bulsara, CF Platell

Cancers (MDPI) Australia, 29 April 2020

Oncology

Key words: SOX2, Colorectal Cancer, Chemotherapy, Prognosis, Oxaliplatin, 5-Fluorouracil, Cancer Stem Cell [more]

ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research

T Glaser, H Shimojo, DE Ribeiro, P Pereira Lopes Martins, R Pereira Beco, M Kosinski, V Fernandes Arnaud Sampaio, J Corrêa-Velloso, A Oliveira-Giacomelli, C Lameu, AP de Jesus Santos, HD Nóbrega de Souza, YD Teng, R Kageyama, H Ulrich

Molecular Psychiatry (Nature) Japan, Brazil, USA, Poland, 29 April 2020

Cell Biology, Neuroscience

Key words: Cell Biology, Diseases, Molecular Biology, Neuroscience [more]

Acute Effects of Pulmonary Exposure to Zinc Oxide Nanoparticles on Brain in Vivo 2

HC Chuang, YT Yang, HC Chen, YH Hwang, KY Wu, TF Chen, CL Chen, MK Jhan, TJ Cheng

Aerosol and Air Quality Research (AAQR) Taiwan, 25 April 2020

Nanomedicine

Key words: Autophagy, Central Nervous System, Elevated Plus Maze, Morris Water Maze, Nanoparticle, Ubiquitin. [more]

A characteristic expression pattern of core circadian genes in the diurnal tree shrew

PH Luo, YM Shu, RJ Ni, YJ Liu, JN Zhou

Neuroscience (Elsevier) China, 25 April 2020

Neuroscience

Key words: Tree Shrew, Diurnal Animal, Circadian Gene, Brain Rhythm, Peripheral Rhythm [more]

In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique

SC Liao, CY Chen, YH Hsu, CT Li, CC Hsieh, MS Tsai, MY Chan, CH Lee, SH Wang, SK NG, HK Tsou, WY Wu

Surface and Coatings Technology (Elsevier) Taiwan, 21 April 2020

Biomaterials

Key words: HiPIMS, TiN, Acrylamide Crosslinking, BMP2 Attachment, In Vitro And In Vivo Studies [more]

Characterization of CD103+ CD8+ tissue‑resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti‑PD‑1 blockade

L Han, QL Gao, XM Zhou, C Shi, GY Chen, YP Song, YJ Yao, YM Zhao, XY Wen, SL Liu, YM Qi, YF Gao

Cancer Immunology, Immunotherpay (Springer) China, 20 April 2020

Oncology, Immunology

Key words: CD103, Tissue-Resident T Cells, Tumor-Infiltrating Lymphocytes, Esophageal Squamous Cell Carcinoma [more]

The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos

ZY Chen, NJ Li, FY Cheng, JF Hsueh, CC Huang, FI Lu, TF Fu, SJ, Yan, YH Lee, YJ Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 20 April 2020

Nanomedicine

Key words: Zebrafish Embryos, Acute Toxicity, Silver Nanoparticles, Chorion Pore Size, Lysosomal Activity, Apoptosis [more]

Macrophages and Fibroblasts Differentially Contribute to Tattoo Stability

H Strandt, O Voluzan, T Niedermair, U Ritter, J Thalhamer, B Malissen, A Stoeklinger, S Henri

Dermatology (Karger) France, Germany, 19 April 2020

Dermatology

Key words: Tattoo, Macrophage, Fibroblast, Tattoo Maintenance [more]

Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit

KH Kim, SJ Lee, J Kim, Y Moon

iScience (Cell Press) South Korea, 18 April 2020

Cell Biology

Key words: CTGF/CCN2, Wnt, Ribosomal Insult, Colorectal Cancer, Tumor Niche [more]

Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma

JR Podojil, AP Glaser, D Baker, ET Courtois, D Fantini, Y Yu, V Eaton, S Sivajothi, M Chiang, A Das, KA McLauglin, P Robson, SD Miller, JJ Meeks

OncoImmunology (Taylor & Francis) USA, 16 April 2020

Oncology, Immunology

Key words: Immunotherapy, Bladder Cancer, Macrophage, T Cell, Checkpoint Inhibitor [more]

Functional diversity between HSP70 paralogs due to variable interactions with specific co-chaperones.

D Serlidaki, MAWH van Waarde, L Rohland, AS Wentink, SL Dekker, MJ Kamphuis, JM Boertien, JF Brunsting, NB Nillegoda, B Bukau, MP Mayer, HH Kampinga, S Bergink

Journal of Biological Chemistry (ASBMB) The Netherlands, Germany, 13 April 2020

Cell Biology

Key words: Hsp110, HSPA4, HSPH2, Protein Folding, Superoxide Dismutase (SOD), 70 Kilodalton Heat Shock Protein (Hsp70), Proteostasis Amyotrophic Lateral Sclerosis (ALS) (Lou Gehrig Disease), Heat Shock Protein (HSP) [more]

IFN-κ suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis

Y He, W Fu, K Cao, Q He, X Ding, J Chen, L Zhu, T Chen, L Ding, Y Yang, C Zhu, S Yuan, Z Li, C Zhao, X Zhang, J Xu

Science Signaling (AAAS) China, 07 April 2020

Immunology

[more]

EMI2 expression as a poor prognostic factor in patients with breast cancer

A Vadhan, YY Wang, SSF Yuan, YC Lee, SCS Hu, JY Huang, T Ishikawa, MF Hou

Kaohsiung Journal of Medical Sciences (Wiley) Taiwan, Japan, 06 April 2020

Oncology

Key words: Breast Cancer, EMI2 (FBXO43), Metastasis

Topography induced stiffness alteration of stem cells influences osteogenic differentiation

L Yang, Q Gao, L Ge, Q Zhou, EM Warszawik, R Bron, KW Lai, P van Rijn

Biomaterials Science (Royal Society of Chemistry) The Netherlands, China, 05 April 2020

Stem Cell Research

[more]

Loss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis

S Lee, HS Roh, SS Song, J Shin, J Lee, DH Bhang,BG Kim, SH Um, HS Jeong, KH Baek

Translational Oncology (Elsevier) South Korea, 03 April 2020

Oncology

[more]

Anti-apoptotic molecule BCL2 is a therapeutic target in steroid-refractory graft-versus-host disease

J Strobl, RV Pandey, T Kausgruber, L Kleißl, B Reininger, M Herac, N Bayer, C Krall, P Wohlfarth, M Mitterbauer, P Kalhs, W Rabitsch, C Bock, G Hopfinger, G Stary

Journal of Investigative Dermatology (Elsevier) Austria, 02 April 2020

Dermatology

[more]

Thyrotropin receptor signaling deficiency impairs spatial learning and memory in mice

S Luan, W Bi, S Shi, L Peng, Z Li, J Jiang, L Gao, Y Du, X Hou, Z He, J Zhao

Journal of Endocrinology (Society for Endocrinology) China, 01 April 2020

Endocrinology

Distinct galectin profile in inflammation-mediated cartilage damage

S Hayer, B Niederreiter, R Windhager, D Aletaha, HJ Gabius, S Toegel

Osteoarthritis and Cartilage (OARSI Journal) Austria, 01 April 2020

Osteology

[more]

Anti-VEGF Treatment Enhances CD8+ T-Cell Antitumor Activity by Amplifying Hypoxia

PE de Almeida, J Mak, G Hernandez, R Jesudason, A Herault, V Javinal, J Borneo, JM Kim, KB Walsh

Cancer Immunology Research (AACR Publications) USA, 27 March 2020

Oncology

Key words: VEGF, CD8+ T Cells, Hypoxia, Angiogenesis, Hypoxia-Inducible Factor-1a [more]

Functionalized graphene oxide thin films for anti-tumor drug delivery to melanoma cells

LE Sima, G Chiritoiu, I Negut, V Grumezescu, S Orobeti, CVA Munteanu, F Sima, E Axente

Frontiers in Chemistry (Frontiers Media S.A.) Romania, 25 March 2020

Nanomedicine

[more]

Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling

KY Lee, PW Shueng, CM Chou, BX Lin, MH Lin, DY Kuo, IL Tsai, SM Wu, CW Lin

Cancer Science (Japanese Cancer Association) Taiwan, 25 March 2020

Oncology

Key words: CD109, EGFR, Lung Cancer, Metastasis, mTOR [more]

Advancements in developing an effective and preventive dengue vaccine

K Zahid, S Shakoor, HA Sajid, S Afzal, L Ali, I Amin, M Shahid, M Idrees

Future Virology (Future Medicine) Pakistan, 24 March 2020

Virology

Key words: Aedes Mosquito, Chimeric Vaccine, Dengue Fever, Dengue Virus, Endemic, Pandemic, Public Health, Subtropical, Tropical, Vaccines

Soluble Alpha-Klotho Alleviates Cardiac Fibrosis without Altering Cardiomyocytes Renewal

WY Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 22 March 2020

Cardiology

Key words: Klotho, FGF-23, Cardiac Fibrosis, Genetic Fate Mapping [more]

Iron and advanced glycation end products: Emerging role of iron in androgen deficiency in obesity

SH Chen, KC Yuan, YC Lee, CK Shih, SH Tseng, AA Tinkov, AV Skalny, JS Chang

Antioxidants (MDPI) Taiwan, 22 March 2020

Endocrinology

Key words: Obesity, Iron, Fat, Advanced Glycation End Products, Testis, Testosterone [more]

Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors

HM Tran, KS Wu, SY Sung, CA Changou, TH Hsieh, YR Liu, YL Liu, ML Tsai, HL Lee, KL Hsieh, WC Huang, ML Liang, HH Chen, YY Lee, SC Lin, DM Ho, FC Chang, ME Chao, W Chen, SS Chu, AL Yu, Y Yen, CC Chang, TT Wong

Cancers (MDPI) Taiwan, Vietnam, 22 March 2020

Oncology

Key words: Myc- ATRTs, Protein Synthesis, Proteasome Degradation, Bortezomib, p53 [more]

Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion

AN Vidyanti, JY Hsieh, KJ Lin, YC Fang, I Setyopranoto, CJ Hu

International Journal of Molecular Sciences (MDPI) Taiwan, 21 March 2020

Neuroscience

Key words: Vascular Cognitive Impairment, Chronic Cerebral Hypoperfusion, Modified Bilateral Common Carotid Artery Occlusion, HMGB1 [more]

Analysis of sensitivity and specificity: precise recognition of neutrophils during regeneration of contused skeletal muscle in rats

J Niu, G An, Z Gu, P Li, Q Liu, R Bai, J Sun, Q Du

Forensic Sciences Research (Taylor & Francis) China, 19 March 2020

Neuroscience

Key words: Forensic Sciences, Forensic Pathology, Immunohistochemistry, TissueFaxs 200 Digital Pathological Analysis System, Parameter Optimization, Cut-Off Value Of Staining Area, Neutrophil Staining Area [more]

Autophagy attenuates high glucose-induced oxidative injury to lens epithelial cells

X Liu, X Zhao, R Cheng, Y Huang

Bioscience Reports (Portland Press) China, 18 March 2020

Endocrinology

Key words: Diabetic Cataract, High Glucose, Autophagy, Oxidative Stress, Lens [more]

MeCP2 mediates transgenerational transmission of chronic pain

W Tao, C Chen, Y Wang, W Zhou, Y Jin, Y Mao, H Wang, L Wang, W Xie, X Zhang, J Li, J Li, X Li, ZQ Tang, C Zhou, ZZ Pan, Z Zhang

Progress in Neurobiology (Elsevier) China, USA, 18 March 2020

Neuroscience

Key words: Chronic Pain, MeCP2, Primary Somatosensory Cortex, Glutamatergic Neuron, Transgenerational Transmission [more]

Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation

CC Ku, K Wuputra, K Kato, WH Lin, JB Pan, SC Tsai, CJ Kuo, KH Lee, YL Lee, YC Lin, S Saito, M Noguchi, Y Nakamura, H Miyoshi, R Eckner, K Nagata, DC Wu, CS Lin, KK Yokoyama

Scientific Reports (Nature) Taiwan, Japan, 18 March 2020

Neuroscience

Key words: Apoptosis, Molecular Neuroscience [more]

Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APC Min/+ mice

L Szeponik, P Akeus, W Rodin, S Raghavan, M Quiding-Järbrink

Cancer Immunology, Immunotherpay (Springer) Sweden, 17 March 2020

Immunology

Key words: Regulatory T Cells, APCmin/+, Colon Cancer, Tumor-Infiltrating Lymphocytes, Anti-Tumor Immunity [more]

Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

ST Li, D Huang, S Shen, Y Cai, S Xing, G Wu, Z Jiang, Y Hao, M Yuan, N Wang, L Zhu, R Yan, D Yang, L Wang, Z Liu, X Hu, R Zhou, K Qu, A Li, X Duan, H Zhang, P Gao

Nature Metabolism (Nature) China, 16 March 2020

Oncology

Key words: Cancer, Cancer Metabolism, Cell Growth [more]

Long-Term Deleterious Effects of Short-term Hyperoxia on Cancer Progression—Is Brain-Derived Neurotrophic Factor an Important Mediator? An Experimental Study

A Tiron, I Ristescu, PA Postu, CE Tiron, F Zugun-Eloae, I Grigoras

Cancers (MDPI) Romania, 14 March 2020

Oncology

Key words: Cancer Progression, Breast Cancer, Hyperoxia, Perioperative, Metastasis, BDNF, Vimentin, E-Cadherin, Epithelial Mesenchymal Transition, Angiogenesis [more]

Proteomic profiling of hepatic stellate cells in alcohol liver fibrosis reveals proteins involved in collagen production

L Yin, Y Zhang, H Shi, Y Feng, L Zhang

Alcohol (Elsevier) China, 12 March 2020

Hepatology

Key words: Ethanol, Liver, HSC, Proteomics, Collagen, Ndufv2 [more]

Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction

C Rutledge, G Cater, B McMahon, L Guo, SM Nouraie, Y Wu, F Villanueva, BA Kaufman

Cardiovascular Ultrasound (BMC) USA, 12 March 2020

Cardiology

[more]

Placental Morphology and Cellular Characteristics in Stillbirths in Women With Diabetes and Unexplained Stillbirths

A Kerby, D Shingleton, G Batra, MC Sharps, BC Baker, AEP Heazell

Archives of Pathology & Laboratory Medicine (College of American Pathologists) UK, 09 March 2020

Reproductive Medicine

[more]

PTH hypersecretion triggered by a GABA B1 and Ca 2+-sensing receptor heterocomplex in hyperparathyroidism

W Chang, CL Tu, FG Jean-Alphonse, A Herberger, Z Cheng, J Hwong, H Ho, A Li, D Wang, H Liu, AD White, I Suh, W Shen, QY Duh, E Khanafshar, DM Shoback, K Xiao, JP Vilardaga

Nature Metabolism (Nature) USA, 09 March 2020

Endocrinology

Key words: Calcium and Vitamin D, Homeostasis, Mechanisms Of Disease, Parathyroid Diseases [more]

Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement

AH Liao, KH Lin, HC Chuang, CH Tsai, YC Lin, CH Wang, CP Shih, HL Liu

Scientific Reports (Nature) Taiwan, 09 March 2020

Tissue Engineering

Key words: Biophysics, Medical Research [more]

Surface functionalization of pegylated gold nanoparticles with antioxidants suppresses nanoparticle-induced oxidative stress and neurotoxicity

X Zhang, XL Guo, X Kang, H Yang, W Guo, L Guan, H Wu, L Du

Chemical Research in Toxicology (ACS Publications) China, 05 March 2020

Toxicology

Key words: Pegylation, Gold Nanoparticle, Neurotoxicity, Drug Delivery [more]

Topography Mediated Fibroblast Cell Migration is Influenced by Direction, Wavelength, and Amplitude

L Ge, L Yang, R Bron, JK Burgess, P van Rijn

ACS Applied Bio Materials (ACS Publications) , 04 March 2020

Biomaterials

Key words: Topography, Gradient, Cell Migration, Biointerface, Wound Healing [more]

A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure

ML Cook Sangar, EJ Girard, G Hopping, C Yin, F Pakiam, MY Brusniak, E Nguyen, R Ruff, MM Gewe, K Byrnes-Blake, NW Nairn, DM Miller, C Mehlin, AD Strand, AJ Mhyre, CE Correnti, RK Strong, JA Simon, JM Olson

Science Translational Medicine (AAAS) USA, 04 March 2020

Endocrinology

[more]

Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma

K Alikhanyan, Y Chen, S Kraut, R Sotillo

Immunity, Inflammation and Disease (Wiley) Germany, 03 March 2020

Immunology, Oncology

Key words: Alveolar Macrophages, Clodronate Liposomes, EGFR Mutation, Interstitial Macrophages, Lung Cancer [more]

Artificial intelligence as the next step towards precision pathology

B Acs, M Rantalainen, J Hartman

Journal of Internal Medicine (Wiley) Sweden, 03 March 2020

Bioimaging

Key words: Artificial Intelligence, Deep Learning, Digital Image Analysis, Digital Pathology, Machine Learning, Pathology

Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes

LY Chou, CH Chen, YH Lin, SC Chuang, HC Chou, SY Lin, YC Fu, JK Chang, ML Ho, CZ Wang

The FASEB Journal (FASEB) Taiwan, 03 March 2020

Osteology

Key words: Chondrocytes, DDR1, Discoidin Domain Receptor 1, Endochondral Ossification, Skeletal Development [more]

Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

C Rapp, S Dettling, F Liu, AT Ull, R Warta, C Jungk, S Roesch, A Mock, F Sahm, M Schmidt, G Jungwirth, K Zweckberger, K Lamszus, K Gousias, AF Kessler, N Grabe, M Loehr, R Ketter, S Urbschat, C Senft, M Westphal, A Abdollahi, J Debus, A von Deimling, A Unterberg, M Simon, CC Herold-Mende

Clinical Cancer Research (AACR Publications) Germany, 02 March 2020

Oncology

Key words: Clinically Aggressive Meningioma, T-Cell Infiltration, Primary and Recurrent Tumors TILs, PD-1 [more]

Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats

YJ Wu, ME Chien, CH Huang, CC Chiang, CC Lin, CW Huang, DM Durand, KS Hsu

Experimental Neurology (Elsevier) Taiwan, USA, 29 February 2020

Neuroscience

Key words: Status Epilepticus, Seizure, Electroencephalography, Mossy Fiber Sproutin, gBrain -Derived Neurotrophic Factor, Transcranial Direct Current Stimulation [more]

The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray

ES Gruber, G Oberhuber, D Pils, T Stork, K Sinn, S Gruber, R Nica, D Kolmer, SD Turner, M Schlederer, J Widder, W Doerr, B Teleky, L Kenner

Cancers (MDPI) Austria, 29 February 2020

Oncology

Key words: Irradiated Rectal Cancer, Immunoscore, Virtual Microscopy, Digital Pathology, Tissue Microarray (TMA) [more]

Dermal fillers do not induce upregulation of NLRP3 inflammasomes or expression of inflammatory cytokines in granulomas

M Reinholz, BM Clanner‐Engelshofen, MV Heppt, E Marsela, Y Kawakami, LG Wiest, LE French, W Stolz, GG Gauglitz

Journal of Cosmetic Dermatology (Wiley) Germany, Japan, 28 February 2020

Dermatology

Key words: Caspase, Fillers, Granulomas, Inflammasome, Interleukins [more]

A transcriptionally distinct CXCL13+ CD103+ CD8+ T-cell population is associated with B-cell recruitment and neoantigen load in human cancer

H Workel, Joyce M Lubbers, Roland Arnold, Thalina M Prins, Pieter van der Vlies, Kim de Lange, Tjalling Bosse, Inge C Van Gool, Florine A Eggink, Maartje CA Wouters, Fenne L Komdeur, Elisabeth C van der Slikke, Carien L Creutzberg, Arjan Kol, Annechien Plat, Mark Glaire, David N Church, Hans W Nijman and Marco de Bruyn

Cancer Immunology Research (AACR Publications) The Netherlands, UK, Canada, 27 February 2020

Oncology

Key words: CXCL13, TGFβ1, Tertiary Lymphoid Structures, CD103+ T Cell, Immune Checkpoint Inhibitors [more]

Ultrasound-responsive neurotrophic factor-loaded microbubble-liposome complex: Preclinical investigation for Parkinson's disease treatment

CY Lin, YC Lin, CY Huang, SR Wu, CM Chen, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 27 February 2020

Neuroscience

Key words: Ultrasound (US)-Targeted Microbubble Destruction (UTMD), Gene Therapy, Blood-Brain Barrier Opening, GDNF, BDNF [more]

cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer

Y He, M Xiao, H Fu, L Chen, L Qi, D Liu, P Guo, L Chen, Y Luo, H Xiao, N Zhang, H Guo

Stem Cells (Wiley) China, 26 February 2020

Oncology

Key words: Cancer Stem Cells, CD133, CD24, CD44, cPLA2α, Epithelial‐Mesenchymal Transition [more]

Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway

H Kim, SC Cho, HJ Jeong, HY Lee, MH Jeong, JH Pyun, D Ryu, MS Kim, YS Lee, MS Kim, SC Park, YI Lee, JS Kang

Journal of Cachexia, Sarcopenia and Muscle (Wiley) South Korea, 25 February 2020

Neuroscience

Key words: Exercise Mimetic, Hypertrophic Response, Indoprofen, Muscle Wasting, Muscle Weakness, PDK1 [more]