Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Filter publications

Customer Publications (A total of 2889 papers published)

1401
A characteristic expression pattern of core circadian genes in the diurnal tree shrew

PH Luo, YM Shu, RJ Ni, YJ Liu, JN Zhou

Neuroscience (Elsevier) China, 25 April 2020

Neuroscience

Key words: Tree Shrew, Diurnal Animal, Circadian Gene, Brain Rhythm, Peripheral Rhythm

Organism: Tree Shrew

Tissue: Brain

1402
In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique

SC Liao, CY Chen, YH Hsu, CT Li, CC Hsieh, MS Tsai, MY Chan, CH Lee, SH Wang, SK NG, HK Tsou, WY Wu

Surface and Coatings Technology (Elsevier) Taiwan, 21 April 2020

Biomaterials

Key words: HiPIMS, TiN, Acrylamide Crosslinking, BMP2 Attachment, In Vitro And In Vivo Studies

Organism: Mouse

Tissue: Skin

1403
Characterization of CD103+ CD8+ tissue‑resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti‑PD‑1 blockade

L Han, QL Gao, XM Zhou, C Shi, GY Chen, YP Song, YJ Yao, YM Zhao, XY Wen, SL Liu, YM Qi, YF Gao

Cancer Immunology, Immunotherpay (Springer) China, 20 April 2020

Oncology, Immunology

Key words: CD103, Tissue-Resident T Cells, Tumor-Infiltrating Lymphocytes, Esophageal Squamous Cell Carcinoma

Organism: Mouse

Tissue: Skin

Pathological State: Cancer

1404
The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos

ZY Chen, NJ Li, FY Cheng, JF Hsueh, CC Huang, FI Lu, TF Fu, SJ, Yan, YH Lee, YJ Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 20 April 2020

Nanomedicine

Key words: Zebrafish Embryos, Acute Toxicity, Silver Nanoparticles, Chorion Pore Size, Lysosomal Activity, Apoptosis

Organism: Zebrafish

Tissue: Whole Organism

1405
Macrophages and Fibroblasts Differentially Contribute to Tattoo Stability

H Strandt, O Voluzan, T Niedermair, U Ritter, J Thalhamer, B Malissen, A Stoeklinger, S Henri

Dermatology (Karger) France, Germany, 19 April 2020

Dermatology

Key words: Tattoo, Macrophage, Fibroblast, Tattoo Maintenance

Organism: Human

Tissue: Skin

1406
Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit

KH Kim, SJ Lee, J Kim, Y Moon

iScience (Cell Press) South Korea, 18 April 2020

Cell Biology

Key words: CTGF/CCN2, Wnt, Ribosomal Insult, Colorectal Cancer, Tumor Niche

Organism: Human

Cell Line: HCT8 and HCT116 cells

1407
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma

JR Podojil, AP Glaser, D Baker, ET Courtois, D Fantini, Y Yu, V Eaton, S Sivajothi, M Chiang, A Das, KA McLauglin, P Robson, SD Miller, JJ Meeks

OncoImmunology (Taylor & Francis) USA, 16 April 2020

Oncology, Immunology

Key words: Immunotherapy, Bladder Cancer, Macrophage, T Cell, Checkpoint Inhibitor

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1408
Functional diversity between HSP70 paralogs due to variable interactions with specific co-chaperones.

D Serlidaki, MAWH van Waarde, L Rohland, AS Wentink, SL Dekker, MJ Kamphuis, JM Boertien, JF Brunsting, NB Nillegoda, B Bukau, MP Mayer, HH Kampinga, S Bergink

Journal of Biological Chemistry (ASBMB) The Netherlands, Germany, 13 April 2020

Cell Biology

Key words: Hsp110, HSPA4, HSPH2, Protein Folding, Superoxide Dismutase (SOD), 70 Kilodalton Heat Shock Protein (Hsp70), Proteostasis Amyotrophic Lateral Sclerosis (ALS) (Lou Gehrig Disease), Heat Shock Protein (HSP)

Organism: Human

Cell Line: HEK293 Cells

1409
IFN-κ suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis

Y He, W Fu, K Cao, Q He, X Ding, J Chen, L Zhu, T Chen, L Ding, Y Yang, C Zhu, S Yuan, Z Li, C Zhao, X Zhang, J Xu

Science Signaling (AAAS) China, 07 April 2020

Immunology

Organism: Mouse

Tissue: Lung

1410
EMI2 expression as a poor prognostic factor in patients with breast cancer

A Vadhan, YY Wang, SSF Yuan, YC Lee, SCS Hu, JY Huang, T Ishikawa, MF Hou

Kaohsiung Journal of Medical Sciences (Wiley) Taiwan, Japan, 06 April 2020

Oncology

Key words: Breast Cancer, EMI2 (FBXO43), Metastasis

1411
Topography induced stiffness alteration of stem cells influences osteogenic differentiation

L Yang, Q Gao, L Ge, Q Zhou, EM Warszawik, R Bron, KW Lai, P van Rijn

Biomaterials Science (Royal Society of Chemistry) The Netherlands, China, 05 April 2020

Stem Cell Research

Organism: Human

Cell Line: hBM-MSCs

1412
Loss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis

S Lee, HS Roh, SS Song, J Shin, J Lee, DH Bhang,BG Kim, SH Um, HS Jeong, KH Baek

Translational Oncology (Elsevier) South Korea, 03 April 2020

Oncology

Organism: Human

Cell Line: Endothelial Cells

1413
Anti-apoptotic molecule BCL2 is a therapeutic target in steroid-refractory graft-versus-host disease

J Strobl, RV Pandey, T Kausgruber, L Kleißl, B Reininger, M Herac, N Bayer, C Krall, P Wohlfarth, M Mitterbauer, P Kalhs, W Rabitsch, C Bock, G Hopfinger, G Stary

Journal of Investigative Dermatology (Elsevier) Austria, 02 April 2020

Dermatology

Organism: Human

Tissue: Skin

1414
Thyrotropin receptor signaling deficiency impairs spatial learning and memory in mice

S Luan, W Bi, S Shi, L Peng, Z Li, J Jiang, L Gao, Y Du, X Hou, Z He, J Zhao

Journal of Endocrinology (Society for Endocrinology) China, 01 April 2020

Endocrinology

1415
Distinct galectin profile in inflammation-mediated cartilage damage

S Hayer, B Niederreiter, R Windhager, D Aletaha, HJ Gabius, S Toegel

Osteoarthritis and Cartilage (OARSI Journal) Austria, 01 April 2020

Osteology

Organism: Mouse

Tissue: Joint Tissue, Bone

Pathological State: Arthritis

1416
Anti-VEGF Treatment Enhances CD8+ T-Cell Antitumor Activity by Amplifying Hypoxia

PE de Almeida, J Mak, G Hernandez, R Jesudason, A Herault, V Javinal, J Borneo, JM Kim, KB Walsh

Cancer Immunology Research (AACR Publications) USA, 27 March 2020

Oncology

Key words: VEGF, CD8+ T Cells, Hypoxia, Angiogenesis, Hypoxia-Inducible Factor-1a

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1417
Functionalized graphene oxide thin films for anti-tumor drug delivery to melanoma cells

LE Sima, G Chiritoiu, I Negut, V Grumezescu, S Orobeti, CVA Munteanu, F Sima, E Axente

Frontiers in Chemistry (Frontiers Media S.A.) Romania, 25 March 2020

Nanomedicine

Organism: Human

Cell Line: HDF cells, NHEM cells

1418
Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling

KY Lee, PW Shueng, CM Chou, BX Lin, MH Lin, DY Kuo, IL Tsai, SM Wu, CW Lin

Cancer Science (Japanese Cancer Association) Taiwan, 25 March 2020

Oncology

Key words: CD109, EGFR, Lung Cancer, Metastasis, mTOR

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

1419
Advancements in developing an effective and preventive dengue vaccine

K Zahid, S Shakoor, HA Sajid, S Afzal, L Ali, I Amin, M Shahid, M Idrees

Future Virology (Future Medicine) Pakistan, 24 March 2020

Virology

Key words: Aedes Mosquito, Chimeric Vaccine, Dengue Fever, Dengue Virus, Endemic, Pandemic, Public Health, Subtropical, Tropical, Vaccines

1420
Soluble Alpha-Klotho Alleviates Cardiac Fibrosis without Altering Cardiomyocytes Renewal

WY Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 22 March 2020

Cardiology

Key words: Klotho, FGF-23, Cardiac Fibrosis, Genetic Fate Mapping

Organism: Mouse

Tissue: Heart

1421
Iron and advanced glycation end products: Emerging role of iron in androgen deficiency in obesity

SH Chen, KC Yuan, YC Lee, CK Shih, SH Tseng, AA Tinkov, AV Skalny, JS Chang

Antioxidants (MDPI) Taiwan, 22 March 2020

Endocrinology

Key words: Obesity, Iron, Fat, Advanced Glycation End Products, Testis, Testosterone

Organism: Rat

Tissue: Liver, Testis

Pathological State: Obesity

1422
Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors

HM Tran, KS Wu, SY Sung, CA Changou, TH Hsieh, YR Liu, YL Liu, ML Tsai, HL Lee, KL Hsieh, WC Huang, ML Liang, HH Chen, YY Lee, SC Lin, DM Ho, FC Chang, ME Chao, W Chen, SS Chu, AL Yu, Y Yen, CC Chang, TT Wong

Cancers (MDPI) Taiwan, Vietnam, 22 March 2020

Oncology

Key words: Myc- ATRTs, Protein Synthesis, Proteasome Degradation, Bortezomib, p53

Organism: Human, Mouse

Tissue: Brain, Xenograft Tumor

1423
Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion

AN Vidyanti, JY Hsieh, KJ Lin, YC Fang, I Setyopranoto, CJ Hu

International Journal of Molecular Sciences (MDPI) Taiwan, 21 March 2020

Neuroscience

Key words: Vascular Cognitive Impairment, Chronic Cerebral Hypoperfusion, Modified Bilateral Common Carotid Artery Occlusion, HMGB1

Organism: Mouse

Tissue: Brain

1424
Analysis of sensitivity and specificity: precise recognition of neutrophils during regeneration of contused skeletal muscle in rats

J Niu, G An, Z Gu, P Li, Q Liu, R Bai, J Sun, Q Du

Forensic Sciences Research (Taylor & Francis) China, 19 March 2020

Neuroscience

Key words: Forensic Sciences, Forensic Pathology, Immunohistochemistry, TissueFaxs 200 Digital Pathological Analysis System, Parameter Optimization, Cut-Off Value Of Staining Area, Neutrophil Staining Area

Organism: Rat

Tissue: Muscle

1425
Autophagy attenuates high glucose-induced oxidative injury to lens epithelial cells

X Liu, X Zhao, R Cheng, Y Huang

Bioscience Reports (Portland Press) China, 18 March 2020

Endocrinology

Key words: Diabetic Cataract, High Glucose, Autophagy, Oxidative Stress, Lens

Organism: Mouse

Tissue: Eye

1426
MeCP2 mediates transgenerational transmission of chronic pain

W Tao, C Chen, Y Wang, W Zhou, Y Jin, Y Mao, H Wang, L Wang, W Xie, X Zhang, J Li, J Li, X Li, ZQ Tang, C Zhou, ZZ Pan, Z Zhang

Progress in Neurobiology (Elsevier) China, USA, 18 March 2020

Neuroscience

Key words: Chronic Pain, MeCP2, Primary Somatosensory Cortex, Glutamatergic Neuron, Transgenerational Transmission

Organism: Mouse

Tissue: Brain

1427
Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation

CC Ku, K Wuputra, K Kato, WH Lin, JB Pan, SC Tsai, CJ Kuo, KH Lee, YL Lee, YC Lin, S Saito, M Noguchi, Y Nakamura, H Miyoshi, R Eckner, K Nagata, DC Wu, CS Lin, KK Yokoyama

Scientific Reports (Nature) Taiwan, Japan, 18 March 2020

Neuroscience

Key words: Apoptosis, Molecular Neuroscience

Organism: Mouse

Tissue: Brain

1428
Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APC Min/+ mice

L Szeponik, P Akeus, W Rodin, S Raghavan, M Quiding-Järbrink

Cancer Immunology, Immunotherpay (Springer) Sweden, 17 March 2020

Immunology

Key words: Regulatory T Cells, APCmin/+, Colon Cancer, Tumor-Infiltrating Lymphocytes, Anti-Tumor Immunity

Organism: Mouse

Tissue: Small Intestine

Pathological State: Cancer

1429
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

ST Li, D Huang, S Shen, Y Cai, S Xing, G Wu, Z Jiang, Y Hao, M Yuan, N Wang, L Zhu, R Yan, D Yang, L Wang, Z Liu, X Hu, R Zhou, K Qu, A Li, X Duan, H Zhang, P Gao

Nature Metabolism (Nature) China, 16 March 2020

Oncology

Key words: Cancer, Cancer Metabolism, Cell Growth

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

1430
Long-Term Deleterious Effects of Short-term Hyperoxia on Cancer Progression—Is Brain-Derived Neurotrophic Factor an Important Mediator? An Experimental Study

A Tiron, I Ristescu, PA Postu, CE Tiron, F Zugun-Eloae, I Grigoras

Cancers (MDPI) Romania, 14 March 2020

Oncology

Key words: Cancer Progression, Breast Cancer, Hyperoxia, Perioperative, Metastasis, BDNF, Vimentin, E-Cadherin, Epithelial Mesenchymal Transition, Angiogenesis

Cell Line: human MDA-MB-231 and murine 4T1 TNBC cell lines

1431
Proteomic profiling of hepatic stellate cells in alcohol liver fibrosis reveals proteins involved in collagen production

L Yin, Y Zhang, H Shi, Y Feng, L Zhang

Alcohol (Elsevier) China, 12 March 2020

Hepathology

Key words: Ethanol, Liver, HSC, Proteomics, Collagen, Ndufv2

Organism: Rat

Tissue: Liver

Pathological State: Liver Fibrosis

1432
Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction

C Rutledge, G Cater, B McMahon, L Guo, SM Nouraie, Y Wu, F Villanueva, BA Kaufman

Cardiovascular Ultrasound (BMC) USA, 12 March 2020

Cardiology

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Infarction

1433
Placental Morphology and Cellular Characteristics in Stillbirths in Women With Diabetes and Unexplained Stillbirths

A Kerby, D Shingleton, G Batra, MC Sharps, BC Baker, AEP Heazell

Archives of Pathology & Laboratory Medicine (College of American Pathologists) UK, 09 March 2020

Reproductive Medicine

Organism: Human

Tissue: Placenta

Pathological State: Diabetes

1434
PTH hypersecretion triggered by a GABA B1 and Ca 2+-sensing receptor heterocomplex in hyperparathyroidism

W Chang, CL Tu, FG Jean-Alphonse, A Herberger, Z Cheng, J Hwong, H Ho, A Li, D Wang, H Liu, AD White, I Suh, W Shen, QY Duh, E Khanafshar, DM Shoback, K Xiao, JP Vilardaga

Nature Metabolism (Nature) USA, 09 March 2020

Endocrinology

Key words: Calcium and Vitamin D, Homeostasis, Mechanisms Of Disease, Parathyroid Diseases

Organism: Mouse

Tissue: Thyroid

1435
Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement

AH Liao, KH Lin, HC Chuang, CH Tsai, YC Lin, CH Wang, CP Shih, HL Liu

Scientific Reports (Nature) Taiwan, 09 March 2020

Tissue Engineering

Key words: Biophysics, Medical Research

Organism: Mouse

Tissue: Skin

1436
Surface functionalization of pegylated gold nanoparticles with antioxidants suppresses nanoparticle-induced oxidative stress and neurotoxicity

X Zhang, XL Guo, X Kang, H Yang, W Guo, L Guan, H Wu, L Du

Chemical Research in Toxicology (ACS Publications) China, 05 March 2020

Toxicology

Key words: Pegylation, Gold Nanoparticle, Neurotoxicity, Drug Delivery

Organism: Mouse

Tissue: Brain

1437
Topography Mediated Fibroblast Cell Migration is Influenced by Direction, Wavelength, and Amplitude

L Ge, L Yang, R Bron, JK Burgess, P van Rijn

ACS Applied Bio Materials (ACS Publications) , 04 March 2020

Biomaterials

Key words: Topography, Gradient, Cell Migration, Biointerface, Wound Healing

Organism: Human

Cell Line: Fibroblasts

1438
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure

ML Cook Sangar, EJ Girard, G Hopping, C Yin, F Pakiam, MY Brusniak, E Nguyen, R Ruff, MM Gewe, K Byrnes-Blake, NW Nairn, DM Miller, C Mehlin, AD Strand, AJ Mhyre, CE Correnti, RK Strong, JA Simon, JM Olson

Science Translational Medicine (AAAS) USA, 04 March 2020

Endocrinology

Organism: Human

Tissue: Joint Tissue

1439
Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma

K Alikhanyan, Y Chen, S Kraut, R Sotillo

Immunity, Inflammation and Disease (Wiley) Germany, 03 March 2020

Immunology, Oncology

Key words: Alveolar Macrophages, Clodronate Liposomes, EGFR Mutation, Interstitial Macrophages, Lung Cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

1440
Artificial intelligence as the next step towards precision pathology

B Acs, M Rantalainen, J Hartman

Journal of Internal Medicine (Wiley) Sweden, 03 March 2020

Bioimaging

Key words: Artificial Intelligence, Deep Learning, Digital Image Analysis, Digital Pathology, Machine Learning, Pathology

1441
Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes

LY Chou, CH Chen, YH Lin, SC Chuang, HC Chou, SY Lin, YC Fu, JK Chang, ML Ho, CZ Wang

The FASEB Journal (FASEB) Taiwan, 03 March 2020

Osteology

Key words: Chondrocytes, DDR1, Discoidin Domain Receptor 1, Endochondral Ossification, Skeletal Development

Organism: Mouse

Tissue: Bone

1442
Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

C Rapp, S Dettling, F Liu, AT Ull, R Warta, C Jungk, S Roesch, A Mock, F Sahm, M Schmidt, G Jungwirth, K Zweckberger, K Lamszus, K Gousias, AF Kessler, N Grabe, M Loehr, R Ketter, S Urbschat, C Senft, M Westphal, A Abdollahi, J Debus, A von Deimling, A Unterberg, M Simon, CC Herold-Mende

Clinical Cancer Research (AACR Publications) Germany, 02 March 2020

Oncology

Key words: Clinically Aggressive Meningioma, T-Cell Infiltration, Primary and Recurrent Tumors TILs, PD-1

Organism: Human

Tissue: Brain

Pathological State: Cancer

1443
Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats

YJ Wu, ME Chien, CH Huang, CC Chiang, CC Lin, CW Huang, DM Durand, KS Hsu

Experimental Neurology (Elsevier) Taiwan, USA, 29 February 2020

Neuroscience

Key words: Status Epilepticus, Seizure, Electroencephalography, Mossy Fiber Sproutin, gBrain -Derived Neurotrophic Factor, Transcranial Direct Current Stimulation

Organism: Rat

Tissue: Brain

Pathological State: Seizures

1444
The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray

ES Gruber, G Oberhuber, D Pils, T Stork, K Sinn, S Gruber, R Nica, D Kolmer, SD Turner, M Schlederer, J Widder, W Doerr, B Teleky, L Kenner

Cancers (MDPI) Austria, 29 February 2020

Oncology

Key words: Irradiated Rectal Cancer, Immunoscore, Virtual Microscopy, Digital Pathology, Tissue Microarray (TMA)

Organism: Human

Tissue: Colon

Pathological State: Cancer

1445
Dermal fillers do not induce upregulation of NLRP3 inflammasomes or expression of inflammatory cytokines in granulomas

M Reinholz, BM Clanner‐Engelshofen, MV Heppt, E Marsela, Y Kawakami, LG Wiest, LE French, W Stolz, GG Gauglitz

Journal of Cosmetic Dermatology (Wiley) Germany, Japan, 28 February 2020

Dermatology

Key words: Caspase, Fillers, Granulomas, Inflammasome, Interleukins

Organism: Human

Tissue: Skin

1446
A transcriptionally distinct CXCL13+ CD103+ CD8+ T-cell population is associated with B-cell recruitment and neoantigen load in human cancer

H Workel, Joyce M Lubbers, Roland Arnold, Thalina M Prins, Pieter van der Vlies, Kim de Lange, Tjalling Bosse, Inge C Van Gool, Florine A Eggink, Maartje CA Wouters, Fenne L Komdeur, Elisabeth C van der Slikke, Carien L Creutzberg, Arjan Kol, Annechien Plat, Mark Glaire, David N Church, Hans W Nijman and Marco de Bruyn

Cancer Immunology Research (AACR Publications) The Netherlands, UK, Canada, 27 February 2020

Oncology

Key words: CXCL13, TGFβ1, Tertiary Lymphoid Structures, CD103+ T Cell, Immune Checkpoint Inhibitors

Organism: Human

Pathological State: Cancer

1447
Ultrasound-responsive neurotrophic factor-loaded microbubble-liposome complex: Preclinical investigation for Parkinson's disease treatment

CY Lin, YC Lin, CY Huang, SR Wu, CM Chen, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 27 February 2020

Neuroscience

Key words: Ultrasound (US)-Targeted Microbubble Destruction (UTMD), Gene Therapy, Blood-Brain Barrier Opening, GDNF, BDNF

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's Disease

1448
cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer

Y He, M Xiao, H Fu, L Chen, L Qi, D Liu, P Guo, L Chen, Y Luo, H Xiao, N Zhang, H Guo

Stem Cells (Wiley) China, 26 February 2020

Oncology

Key words: Cancer Stem Cells, CD133, CD24, CD44, cPLA2α, Epithelial‐Mesenchymal Transition

Organism: Human

Tissue: Uterus

Pathological State: Cancer

1449
Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway

H Kim, SC Cho, HJ Jeong, HY Lee, MH Jeong, JH Pyun, D Ryu, MS Kim, YS Lee, MS Kim, SC Park, YI Lee, JS Kang

Journal of Cachexia, Sarcopenia and Muscle (Wiley) South Korea, 25 February 2020

Neuroscience

Key words: Exercise Mimetic, Hypertrophic Response, Indoprofen, Muscle Wasting, Muscle Weakness, PDK1

Organism: Mouse

Tissue: Muscle

1450
Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations

P Chen, S Lou, ZH Huang, Z Wang, QH Shan, Y Wang, Y Yang, X Li, H Gong, Y Jin, Z Zhang, JN Zhou

Neuron (Cell Press) China, 25 February 2020

Neuroscience

Key words: Corticotropin-Releasing Factor Neurons, Prefrontal Cortex, Behavioral Style Selection, Social Defeat Stress

Organism: Mouse

Tissue: Brain

1451
Sox2 induces tumorigenesis and angiogenesis of early-stage esophageal squamous cell carcinoma through secretion of Suprabasin

K Takahashi, N Asano, A Imatani, Y Kondo, M Saito, A Takeuchi, X Jin, M Saito, W Hatta, K Asanuma, K Uno, T Koike, A Masamune

Carcinogenesis (Oxford University Press) Japan, 14 February 2020

Oncology

Key words: Sox2, Esophageal Cancer, Suprabasin, Carcinogenesis, Angiogenesis

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

1452
The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental Study on Porcine Models

T Andrašina, J Jaroš, T Jůza, T Rohan, D Červinka, M Crha, V Válek, NS Goldberg

CardioVascular and Interventional Radiology (Springer) Czech Republic, Israel, 13 February 2020

Cardiology

Key words: Liposomal Doxorubicin, Radiofrequency Ablation, Irreversible Electroporation

Organism: Pig

Tissue: Liver

1453
The Impact of Cand1 in Prostate Cancer

A Eigentler, P Tymoszuk, J Zwick, AA Schmitz, A Pircher, F Kocher, A Schlicker, R Lesche, G Schäfer, I Theurl, H Klocker, I Heidegger

Cancers (MDPI) Austria, Germany, 12 February 2020

Oncology

Key words: Prostate Cancer, Cand1, Cancer Aggressiveness, Survival, Tumor Recurrence, Mutation, Enzalutamide Resistance

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1454
Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance

J Dudas, A Ladanyi, J Ingruber, TB Steinbichler, H Riechelmann

Cells (MDPI) Austria, Hungary, 12 February 2020

Oncology

Key words: Silibinin, MRX34, PD-L1, NRF2, Krüppel-Like Factors (KLFs), Neurotrophin

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

1455
MRI radiomics for early prediction of response to vaccine therapy in a transgenic mouse model of pancreatic ductal adenocarcinoma

A Eresen, J Yang, J Shangguan, Y Li, S Hu, C Sun, Y Velichko, V Yaghmai, AB Benson, Z Zhang

Journal of Translational Medicine (BMC) USA, China, 10 February 2020

Gastroenterology

Key words: Dendritic Cell Vaccine, Machine Learning, Magnetic Resonance Imaging, Pancreatic Ductal Adenocarcinoma, Radiomics

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

1456
Single cell approaches to address adipose tissue stromal cell heterogeneity

EA Rondini, JG Granneman

Biochemical Journal (Portland Press) USA, 06 February 2020

Endocrinology

Key words: Plasticity, Single Cell RNA-Seq, Stromal Cells, White Adipose Tissue

1457
Acquisition of chromosome instability is a mechanism to evade oncogene addiction

L Salgueiro, C Buccitelli, K Rowald, K Somogyi, S Kandala, JO Korbel, R Sotillo

EMBO Molecular Medicine (EMBO press) Germany, 06 February 2020

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1458
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability

WC Liao, CK Liao, TJ Tseng, YJ Ho, YR Chen, KH Lin, TJ Lai, CT Lan, KC Wie, CH Liu

Oncogenesis (Nature) Taiwan, 04 February 2020

Oncology

Key words: CNS Cancer, Growth Factor Signalling

Organism: Human

Tissue: Brain

Pathological State: Cancer

1459
Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy

Y Luo, S Lu, Y Gao, K Yang, D Wu, X Xu, G Sun, X Sun

Aging (Impact Journals) China, 31 January 2020

Cardiology

Key words: Atherosclerosis, Macrophage Polarization, Autophagy, Sirt1, Araloside C

Organism: Mouse

Tissue: Heart

Pathological State: Atherosclerosis

1460
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I

F Bufalieri, M Caimano, L Lospinoso Severini, I Basili, F Paglia, L Sampirisi, E loricchio, M Petroni, G Canettieri, A Santoro, L D'Angelo, P Infante, L Di Marcotullio

Cancers (MDPI) Italy, 30 January 2020

Oncology

Key words: Glioblastoma Multiforme (GB), Ubiquitylation, E3-Ligase, MEX3A, RIG-I

Organism: Human

Pathological State: Cancer

Cell Line: glioblastoma A-172 cells

1461
Unidirectional rotating molecular motors dynamically interact with adsorbed proteins to direct the fate of mesenchymal stem cells

Q Zhou, J Chen, Y Luan, PA Vainikka, S Thallmair, SJ Marrink, BL Fering, P van Rijn

Science Advances (AAAS) China, The Netherlands, 29 January 2020

Biomaterials

Organism: Human

Cell Line: hBM-MSCs Cells

1462
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas

J He, Z Huang, M He, J Liao, Q Zhang, S Wang, L Xie, L Ouyang, HP Koeffler, D Yin, A Liu

Molecular Cancer (BMC) China, USA, 28 January 2020

Oncology

Key words: Circ-MAPK4, P38/MAPK Signaling Pathway, MiR-125a-3p, Gliomas, Apoptosis

Organism: Mouse

Tissue: Xenograft Tumor, Brain

Pathological State: Cancer

1463
Cytotoxic CD4+ T lymphocytes may induce epithelial cell apoptosis in systemic sclerosis

T Maehara, N Kaneko, CA Perugino, H Mattoo, J Kers, H Allard-Chamard, VS Mahajan, H Liu, SJH Murphy, M Ghebremichael, DA Fox, AS Payne, R Lafyatis, JH Stone, D Khanna, S Pillai

The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, Japan, The Netherlands, Canada, China, 28 January 2020

Immunology

Organism: Human

Tissue: Skin

1464
The Establishment of Esophageal Precancerous Lesion Model by Using p53 Conditional Knockout Mouse in Esophageal Epithelium

L Zhu, Y Xu, X Chen, J Qin, T Niu, Y Zhu, Y Jiang, S Zhao, K Liu, J Lu, G Jin, J Ma

BioMed Research International (Hindawi Publishing Corporation) China, 25 January 2020

Oncology

Organism: Mouse

Tissue: Esophagus

1465
Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice

N Ran, X Gao, X Dong, J Li, C Lin, M Geng, HF Yin

Biomaterials (Elsevier) China, 25 January 2020

Biomaterials

Key words: Exosome, Duchenne Muscular Dystrophy, Myostatin, Propeptide

Organism: Rat

Tissue: Muscle, Liver, Kidney

1466
Surfactant expression defines an inflamed subtype of lung adenocarcinoma brain metastases that correlates with prolonged survival

K Pocha, A Mock, C Rapp, S Dettling, R Warta, C Geisenberger, C Jungk, LR Martins, N Grabe, D Reuss, J Debus, A von Deimling, A Abdollahi, A Unterberg, CC Herold-Mende

Clinical Cancer Research (AACR Publications) Germany, 17 January 2020

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

1467
Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation

E Jo, HJ Jang, KE Yang MS Jang, YH Huh, HS Yoo, JS Park, IK Jang, SJ Park

BMC Complementary Medicine and Therapies (BMC) South Korea, 13 January 2020

Oncology

Key words: Apoptosis, TNF-α, TNFR1, NF-κB, C. Militaris

Organism: Human

Cell Line: SKOV-3 Cells

1468
High Extra-tumoral Mast Cell Counts are Associated with a Higher Risk of Adverse Prostate Cancer Outcomes

HH Sullivan, CM Heaphy, I Kulac, N Cuka, J Lu, JR Barber, AM De Marzo, TL Lotan, CE Joshu, KS Sfanos

Cancer Epidemiology, Biomarkers & Prevention (AACR Publications) USA, 13 January 2020

Oncology

1469
Novel titanium-apatite hybrid scaffolds with spongy bone-like micro architecture intended for spinal application: In vitro and in vivo study

MD Vlad, EF Aguado, SG González, IC Ivanov, EV Sindilar, I Poeata, AS Iencean, M Butnaru, ER Avadanei, J Lopez Lopez

Materials Science and Engineering: C (Elsevier) Romania, Spain, 11 January 2020

Biomaterials

Key words: Titanium-Apatite Hybrid Scaffolds, Osteogenic Biomimetic Porous Scaffolds, Hydroxyapatite Bioactive Matrix, Bone Restoration, Spinal Fusion, Additive Manufacturing

Organism: Human

Cell Line: Osteoblasts

1470
Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer

CW Chang, HC Lee, LH Li, JS Chiang Chiau, TE Wang, WH Chuang, MJ Chen, HY Wang, SC Shih, CY Liu, TH Tsai, YJ Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 08 January 2020

Oncology, Microbiology

Key words: FOLFOX, Fecal Microbiota Transplant, Intestinal Mucositis, Apoptosis, Gut Microbiota

Organism: Mouse

Tissue: Small Intestine

Pathological State: Cancer

1471
Impact of the Sensory and Sympathetic Nervous System on Fracture Healing in Ovariectomized Mice

T Niedermair, RH Straub, C Brochhausen, S Grässel

International Journal of Molecular Sciences (MDPI) Germany, 08 January 2020

Neuroscience

Key words: Fracture, Substance P, Alpha-CGRP, Sympathectomy, Sympathetic Nerve Fibers, Ovariectomy, Sensory Nervous System, Bone Repair, Bone Remodeling

Organism: Mouse

Tissue: Bone

1472
Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model

D Muschter, L Fleischhauer, S Taheri, AF Schilling, H Clausen-Schaumann, S Grässel

Bone (Elsevier) Germany, 08 January 2020

Osteology

Key words: Osteoarthritis, Destabilization of The Medial Meniscus, Substance P, Alpha- Calcitonin Gene-Related Peptide, Bone, Cartilage

Organism: Mouse

Tissue: Bone

1473
Racial difference in prostate cancer cell telomere lengths in men with higher-grade prostate cancer: a clue to the racial disparity in prostate cancer outcomes

CM Heaphy, CE Joshu, JR Barber, C Davis, R Zarinshenas, AM De Marzo, TL Lotan, KS Sfanos, AK Meeker, EA Platz

Cancer Epidemiology, Biomarkers & Prevention (AACR Publications) USA, 08 January 2020

Oncology

1474
Efficient Labeling Of Mesenchymal Stem Cells For High Sensitivity Long-Term MRI Monitoring In Live Mice Brains

AAA Ali, RA Shahror, KY Chen

International Journal of Nanomedicine (Dove Press) Taiwan, 08 January 2020

Nanomedicine

Key words: Iron Oxide Nanoparticles, FGF21, Regenerative Medicine, Tracking of Cells, Non-Invasive Imaging Modality

Organism: Human

Cell Line: Mesenchymal Stem Cells

1475
Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway

D Liu, H Wang, Y Zhang, Z Zhang

Drug Design, Development and Therapy (Dove Press) China, 07 January 2020

Neuroscience

Key words: Cerebral Ischemia/Reperfusion Injury, Chlorogenic Acid, Oxidative Stress, Neuroprotection, NF-E2-Related Factor 2 Pathway

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

1476
The MyoD family inhibitor domain-containing protein enhances the chemoresistance of cancer stem cells in the epithelial state by increasing β-catenin activity

CJ Chen, CJ Yang, SF Yang, MS Huang, YP Liu

Oncogene (Nature) Taiwan, 07 January 2020

Oncology

Key words: Non-Small Lung Cancer, Prognostic

Organism: Human

Tissue: Lung

Pathological State: Cancer

1477
TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior

CH Chu, JS Chen, PC Chuang, CH Su, ZL Chan, ZJ Zang, ZT Chiang, PW Gean, HS Sun

The FASEB Journal (Wiley) Taiwan, 07 January 2020

Neuroscience

Key words: Guanine Nucleotide Exchange Factor (GEF), Hyperlocomotion, Neuroplasticity, Serotonergic Fiber, Serotonin (5‐HT), TIAM2

Organism: Mouse

Tissue: Brain

1478
Microvascular Disease in Chronic Thromboembolic Pulmonary Hypertension: Hemodynamic Phenotyping and Histomorphometric Assessment

C Gerges, M Gerges, R Friewald, P Fesler, P Dorfmüller, S Sharma, K Karlocai, N Skoro-Sajer, J Jakowitsch, B Moser, S Taghavi, W Klepetko, IM Lang

Circulation (American Heart Association) Austria, Germany, France, Hungary, 03 January 2020

Cardiology

Key words: Chronic Thromboembolic Pulmonary Hypertension, Upstream Resistance, Pulmonary Vascular Resistance, Pulmonary Arterial Compliance, Microvascular Disease

Organism: Human

Tissue: Lung

1479
Anti-BAFF treatment interferes with humoral responses in a model of renal transplantation in rats

L Steines, H Poth, A Schuster, EK Geissler, K Amann, B Banas, T Bergler

Transplantation (Wolters Kluwer) Germany, 01 January 2020

Transplantation Medicine

Organism: Rat

Tissue: Kidney

1480
Effects of neoadjuvant FOLFIRONOX and gemcitabine-based chemotherapy on cancer cell survival and death in patients with pancreatic ductal adenocarcinoma

L Xie, L Xia, U Klaiber, M Sachsenmaier, U Hinz, F Bergmann, O Strobel, MW Büchler, JP Neoptolemos, F Fortunato, T Hackert

Oncotarget (Impact Journals) Germany, 31 December 2019

Oncology

Key words: autophagy, cell death, stroma, neoadjuvant therapy, prognosis

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

1481
Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo

JH Chen, I Chiang, FT Hsu

Cancers (MDPI) Taiwan, 30 December 2019

Oncology

Key words: Magnolol, Sorafenib, AKT, Hepatocellular carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1482
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra

YC Kao, WY Wei, KJ Tsai, LC Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 27 December 2019

Neuroscience

Key words: high-fat diet (HFD), dopamine (DA), Parkinson disease (PD), peroxisome proliferator-activated receptor (PPAR)

Organism: Mouse

Tissue: Brain

1483
Nanoplatforms with Remarkably Enhanced Absorption in the Second Biological Window for Effective Tumor Thermo-Radiotherapy

C Zhang, D Men, T Zhang, Y Yu, J Xiang, G Jiang, and L Han

ACS Applied Materials & Interfaces (ACS Publications) China, 25 December 2019

Nanomedicine

Key words: Copper sulfide, Gold, Second near-infrared window, Thermo-radiotherapy, Synergistic effect

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1484
Dendritic cells treated with a prostaglandin I2 analog, iloprost, promote antigen-specific regulatory T cell differentiation in mice

TH Wong, RJ Gau, YF Chen, HH Shen, CTY Lin, SL Chen, JL Suen

International Immunopharmacology (Elsevier) Taiwan, 23 December 2019

Immunology

Key words: Allergic inflammation, Prostaglandin I2, mPEG-PLGA hydrogel, Regulatory T-cell, Tolerogenic dendritic cell, PD-L1

Organism: Mouse

Tissue: Lung

1485
Heat-killed Mycobacterium paragordonae therapy exerts an anti-cancer immune response via enhanced immune cell mediated oncolytic activity in xenograft mice model

SY Lee, SB Yang, YM Choi, SJ Oh, BJ Kim, YH Kook, BJ Kim

Cancer Letters (Elsevier) South Korea, 23 December 2019

Oncology

Key words: Cancer immnotherapy, Natural killer cells, Dendritic cells, Interleukin-12

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

1486
Switching to a Healthy Diet Prevents the Detrimental Effects of Western Diet in a Colitis-Associated Colorectal Cancer Model

C Gröschel, M Prinz-Wohlgenannt, I Mesteri, S Karuthedom George, L Trawnicek, D Heiden, A Aggarwal, S Tennakoon, M Baumgartner, C Gasche, M Lang, R Marculescu, T Manhardt, M Schepelmann, E Kallay

Nutrients (MDPI) Austria, Germany, 23 December 2019

Oncology, Gastroenterology

Key words: inflammatory bowel disease, colitis-associated cancer, microbiome, western diet, vitamin D, non-alcoholic fatty liver disease, CYP24A1, Wnt pathway, aberrant crypt foci, mucosal regeneration

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

1487
Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer

JY Huang, YY Wang, S Lo, LM Tseng, DR Chen, YC Wu, MF Hou, SSF Yuan

Cancers (MDPI) Taiwan, 20 December 2019

Oncology

Key words: Breast cancer, Visfatin, Adipose-derived stem cells (ADSCs), GDF15

Organism: Human

Tissue: Breast

Pathological State: Cancer

1488
Modulating Macrophage Phenotype by Sustained MicroRNA Delivery Improves Host‐Implant Integration

J Lin, I Mohamed, PH Lin, H Shirahama, U Milbreta, JL Sieow, Y Peng, M Bugiani, SC Wong, H Levinson, SY Chew

Advanced Healthcare Materials (Wiley) Singapore, USA, The Netherlands, 18 December 2019

Tissue Engineering

Key words: Electrospinning, Fibrous capsule formation, Gene silencing, RNA interference, Tissue engineering

Organism: Mouse

1489
Rhubarb-evoke Mucus Secretion through Aggregation and Degranulation of Mast cell in the colon of Rat: in vivo and ex vivo studies

D Wu, X Xue, C Gao, Y Liu, T Wang, L Li, X Tong, F Li, J Xu

Scientific Reports (Nature) China, 18 December 2019

Gastroenterology

Key words: Gastroenterology, Physiology

1490
Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence

M Jäger, C De la Torre, C Arnold, J Kohlhaas, L Kappert, M Hecker, A Feldner, T Korff

Experimental Cell Research (Elsevier) Germany, 16 December 2019

Tissue Engineering

Key words: TGF, Vascular smooth muscle cells, Differentiation, 3D culture

Organism: Human

Cell Line: HUASMCs

1491
Effects of Circadian Rhythm Disorder on the Hippocampus of SHR and WKY Rats

YL Wang, YG Zhang, WZ Wang, X Liu, YF Chi, JF Lei, BG Zhang, T Zhang

Neurobiology of Learning and Memory (Elsevier) China, 16 December 2019

Neuroscience

Key words: Circadian rhythm disorder, Hypertension, Cognition, Hippocampus

Organism: Rat

Tissue: Brain

Pathological State: Circadian Rhythm Disorder

1492
Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice

T Elajnaf, L Iamartino, I Mesteri, C Müller, M Bassetto, T Manhardt, S Baumgartner-Parzer, E Kallay, M Schepelmann

Nutrients (MDPI) Austria, Germany, UK, 16 December 2019

Gastroenterology

Key words: IBD, Colitis, Inflammation, Calcium, Mucin

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

1493
Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations

DY Zhang, C Dmello, Li Chen, VA Arrieta, E Gonzalez-Buendia, JR Kane, LP Magnusson, A Baran, CD James, C Horbinski, A Carpentier, C Desseaux, M Canney, M Muzzio, R Stupp, AM Sonabend

Clinical Cancer Research (AACR Publications) USA, Mexico, France, 12 December 2019

Oncology

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

1494
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice

KC Wood, BG Durgin, HM Schmidt, SA Hahn, JJ Baust, T Bachman, DA Vitturi, S Ghosh, SF Ofori-Acquah, AL Mora, MT Gladwin, AC Straub

Blood Advances (ASH Publications) USA, 10 December 2019

Cardiology

Organism: Mouse

Tissue: Heart

1495
Targeting FOXA1-mediated repression of TGF-b signaling suppresses castration-resistant prostate cancer progression

B Song, SH Park, JC Zhao, KW Fong, S Li, Y Lee, YA Yang, S Sridhar, X Lu, SA Abdulkadir, RL Vessella, C Morrissey, TM Kuzel, W Catalona, X Yang, J Yu

JCI Insight (American Society of Clinical Investigation) USA, 04 December 2019

Oncology

Key words: Genetics, Oncology, Prostate Cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1496
Molecular Pattern and Density of Axons in the Long Head of the Biceps Tendon and the Superior Labrum

S Boesmueller, R Blumer, B Gesslbauer, L Hirtler, C Fialka, R Mittermayr

Journal of Clinical Medicine (MDPI) Austria, 03 December 2019

Physiology

Key words: axons, pain, long head of the biceps tendon, superior labrum, SLAP

Organism: Human

Tissue: Connective Tissue

1497
Early appearance of key transcription factors influence the spatiotemporal development of the human inner ear

LJ Chacko, C Sergi, T Eberharter, J Dudas, H Rask-Anderson, R Hoermann, H Fritsch, N Fischer, R Glueckert, A Schrott-Fischer

Cell and Tissue Research (Springer) Austria, Canada, Sweden, 02 December 2019

Developmental Biology

Key words: Inner ear, Human, Transcription factors, Immunohistochemistry, SOX2, TAK1, GATA3, Electron microscopy

Organism: Human

Tissue: Bone

1498
PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes

MH Jeong, HJ Jeong, BY Ahn, JH Pyun, I Kwon, H Cho, JS Kang

Cell Death & Disease (Nature) South Korea, 02 December 2019

Cardiology

Key words: Cell death, Heart failure

Organism: Mouse

Tissue: Heart

1499
Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease: A case report

T Maehara, R Munemura, M Shimizu, N Kakizoe, N Kaneko, Y Murakami, M Masafumi, T Kiyoshima, S Kawano, S Nakamura

Medicine (Wolters Kluwer) Japan, USA, 01 December 2019

Immunology

Key words: CD4+ T cell, CD4+ GATA3+ T cell, IgE, Kimura disease, mast cell

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Kimura Disease

1500
Histologic Analysis of Sensory and Motor Axons in Branches of the Human Brachial Plexus

LM Mioton, GA Dumanian, A Gregory, M de la Garza, JH Ko

Plastic and Reconstructive Surgery (American Society of Plastic Surgeons) USA, 01 December 2019

Regenerative Medicine

Organism: Human

Tissue: Nerves

1501
Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI

T Chiba, KD Peasley, KR Cargill, KV Maringer, SS Bharathi, E Mukherjee, Y Zhang, A Holtz, N Basisty, SD Yagobian, B Schilling, ES Goetzman, S Sims-Lucas

Journal of The American Society of Nephrology (American Society of Nephrology) USA, 29 November 2019

Nephrology

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

1502
Development of Kaempferol-Loaded Gelatin Nanoparticles for the Treatment of Corneal Neovascularization in Mice

YL Chuang, HW Fang, A Ajitsaria, KH Chen, CY Su, GS Liu, CL Tseng

Pharmaceutics (MDPI) Taiwan, Australia, 28 November 2019

Nanomedicine

Key words: gelatin nanoparticles, kaempferol, corneal neovascularization, anti-angiogenesis, human umbilical vascular endothelial cells (HUVECs)

Organism: Mouse

Tissue: Eye

1503
DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

SC Lai, YT Su, CC Chi, YC Kuo, KF Lee, YC Wu, PC Lan, MH Yang, TS Chang, YH Huang

Journal of Experimental & Clinical Cancer Research (BMC) Taiwan, 26 November 2019

Oncology

Key words: , Interleukin-6, Phospho-STAT3, OCT4, DNMT3b, Drug resistance, Hepatocellular carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1504
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

A Lercher, A Bhattacharya, AM Popa, M Caldera, MF Schlapansky, H Baazim, B Agerer, B Gürtl, L Kosack, P Májek, JS Brunner, D Vitko, T Pinter, JW Genger, A Orlova, N Pikor, D Reil, M Ozsvár-Kozma, U Kalinke, B Ludewig, R Moriggl, KL Bennett, J Menche, PN Cheng, G Schabbauer, M Trauner, K Klavins, A Bergthaler

Immunity (Elsevier) Austria, USA, Switzerland, Germany, China, 26 November 2019

Immunology

Key words: CD8 T cells, hepatitis, hepatocyte, immunometabolism, infection, inflammation, interferons, liver, urea cycle, virus

Organism: Mouse

Tissue: Liver

Pathological State: LCMV Infection

1505
Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice

CM Smith, MK Proulx, R Lai, MC Kiritsy, TA Bell, P hock, FP de Villena, MT Ferris, RE Baker, SM Behar, CM Sassetti

mBio (American Society for Microbiology) USA, 26 November 2019

Microbiology

Key words: Mycobacterium tuberculosis, adaptive immunity, Collaborative Cross mice, host genetics, host response, host-pathogen interactions

Organism: Mouse

Tissue: Lung

Pathological State: Tuberculosis

1506
Promising Therapeutic Efficacy of GC1118, an Anti-EGFR Antibody, against KRAS Mutation-Driven Colorectal Cancer Patient-Derived Xenografts

HW Lee, E Son, K Lee, Y Lee, Y Kim, JC Lee, Y Lim, M Hur, D Kim, DH Nam

International Journal of Molecular Sciences (MDPI) South Korea, 24 November 2019

Oncology

Key words: colorectal cancer, patient-derived xenograft, EGFR-targeting therapeutic antibody, KRAS mutation, PI3K/mTOR/AKT inhibitor

Organism: Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

1507
Translational interest of immune profiling

PN Pushparaj

Precision Medicine for Investigators, Practitioners and Providers (Elsevier) Saudi Arabia, 22 November 2019

Immunology

Key words: Biomarkers, Immunoprofiling, Multiplex Immunohistochemistry, Novel Therapies, Next Generation Sequencing, Protein Arrays, Translational Research, xMAP Assays

1508
Influence of Platelet Lysate on 2D and 3D Amniotic Mesenchymal Stem Cell Cultures

M Pasztorek, E Rossmanith, C Mayr, F Hauser, J Jacak, A Ebner, V Weber, MB Fischer

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) Austria, 15 November 2019

Regenerative Medicine

Key words: mesenchymal stem cells, stress fibers, mitochondrial dynamics, platelet lysate, membrane elasticity

Organism: Human

Cell Line: hMSCs

1509
Cordycepin inhibits human ovarian cancer by inducing autophagy and apoptosis through Dickkopf-related protein 1/β-catenin signaling

HJ Jang, KE Yang, IH Hwang, YH Huh, DJ Kim, KS Yoo, SJ Park, IS Jang

American Journal of Translational Regulation (NCBI) South Korea, 15 November 2019

Oncology

Key words: Apoptosis, Dickkopf-related protein 1, β-catenin, autophagy, cordycepin

Organism: Human

Pathological State: Cancer

Cell Line: SKOV-3, OVCAR-3

1510
Endoplasmic reticulum stress-mediated basolateral amygdala GABAergic neuron injury is associated with stress-induced mental disorders in rats

S Wang, W Shi, G Zhang, X Zhang, C Ma, K Zhao, B Cong, Y Li

Frontiers in Cellular Neuroscience (NCBI) China, Usa, Mexico, 14 November 2019

Neuroscience

Key words: stress, amygdala, GABAergic neurons, mental disorder, endoplasmic reticulum stress

Organism: Rat

Tissue: Brain

1511
Large‐scale Production of LGR5‐positive Bipotential Human Liver Stem Cells

K Schneeberger, N Sánchez‐Romero, S Ye, FG van Steenbeek, LA Oosterhoff, I Pla Palacin, C Chen, ME van Wolferen, G van Tienderen, R Lieshout, H Colemonts‐Vroninks, I Schene, R Hoekstra, MMA Verstegen, LJW van der Laan, LC Penning, SA Fuchs, H Clevers, J De Kock, PM Baptista, B Spee

Hepatology (AASLD) The Netherlands, Spain, Belgium, 12 November 2019

Hepathology

Key words: Liver organoids, suspension culture, spinner flask, hepatocyte differentation, tissue engineering

Organism: Human

Tissue: Liver

1512
Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection

PL Brazee, L Morales-Nebreda, ND Magani, JGN Garcia, AV Misharin, KM Ridge, GRS Budinger, K Iwai, LA Dada, JI Sznajder

The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, Japan, 12 November 2019

Immunology

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection

1513
P2Y6 and P2X7 receptor antagonism exerts neuroprotective/neuroregenerative effects in an animal model of Parkinson's disease

Á Oliveira-Giacomelli, CM Albino, HD Nobrega de Souza, J Correa-Velloso, AP de Jesus Santos, J Baranova, H Ulrich

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) Brazil, 08 November 2019

Neuroscience

Key words: purinergic receptors, Brilliant Blue G, P2X7 receptor, MRS2578, P2Y6 receptor, Parkinson's disease, microglia

Organism: Rat

Tissue: Brain

Pathological State: Parkinson's Disease

1514
A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer

L Ding, J Li, C Wu, F Yan, X Li, S Zhang

Journal of Materials Chemistry B (Royal Society of Chemistry) China, 08 November 2019

Nanomedicine, Oncology

Organism: Human

Pathological State: Cancer

Cell Line: MDA-MB-231 cells, MCF-7 cells and HeLa cells

1515
Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival

S Lu, D Wu, G Sun, F Geng, Y Shen, J Tan, X Sun, Y Luo

Pharmaceutical Biology (Taylor & Francis) China, 07 November 2019

Gastroenterology

Key words: Periplaneta americana L., gastric diseases, IGF-1/PTEN/Akt signalling, KFX

Organism: Rat

Tissue: Stomach

Pathological State: Gastric Ulcer

1516
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis

CM Mazur, JJ Woo, CS Yee, AJ Fields, C Acevedo, KN Bailey, S Kaya, TW Fowler, JC Lotz, A Dang, AC Kuo, TP Vail, T Alliston

Bone research (Nature) USA, 05 November 2019

Osteology

Key words: Bone, Bone quality and biomechanics, Pathogenesis

Organism: Human

Tissue: Bone

1517
Well Plate Integrated Topography Gradient Screening Technology for Studying Cell‐Surface Topography Interactions

TAB van der Boon, L Yang, L Li, DE Cordova, Galvan, Q Zhou, J e Boer, P van Rijn

Advanced Biosystems (Wiley) The Netherlands, China, 04 November 2019

Biomaterials

Key words: Biointerfaces, gradients, high-throughput screening, stem cells surface topography

Organism: Human

Cell Line: hBM-MSCs

1518
Mapping of c-Fos expression in male tree shrew forebrain

RJ Ni, J Wang, YM Shu, L Xu, JN Zhou

Neuroscience letters (Elsevier) China, 03 November 2019

Neuroscience

Key words: Aversive stimulus, Prefrontal cortex, Lateral septal nucleus, Bed nucleus of the stria terminalis, Hypothalamus, Amygdala

Organism: Tree Shrew

Tissue: Brain

1519
Dendritic cell immunotherapy induces anti-tumor effect in a transgenic mouse model of pancreatic ductal adenocarcinoma

J Yang, S Hu, J Shangguan, A Eresen, Y Li, L Pan, Q Ma, Y Velichko, J Wang, C Hu, V Yagmai, Z Zhang

American Journal of Cancer Research (NCBI) USA, China, 01 November 2019

Oncology

Key words: Pancreatic ductal adenocarcinoma, DC-based immunotherapy, magnetic resonance imaging

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

1520
Phospholipase D2 in prostate cancer: protein expression changes with Gleason score

AR Noble, K Hogg, R Suman, DM Berney, S Bourgoin, NJ Maitland, MG Rumsby

British Journal of Cancer (Nature) UK, Canada, 01 November 2019

Oncology

Key words: Cell growth, Prostate cancer, Time-lapse imaging

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1521
A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer

HW Chiu, YL Yeh, SY Ho, YH Wu, B Wang Jr, WJ Huang, YS Ho, YJ Wang, LC Chen, SH Tu

Cancers (MDPI) Taiwan, 01 November 2019

Oncology

Key words: histone deacetylase inhibitor, aggresome, radiation, autophagy, triple-negative breast cancer

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

1522
Directional topography gradients drive optimum alignment and differentiation of human myoblasts

AMA Suarez, Q Zhou, P van Rijn, MC Harmsen

Journal of Tissue Engineering and Regenerative Medicine (Wiley) The Netherlands, 01 November 2019

Regenerative Medicine

Key words: Myoblasts, Myotubes, Polydimethylsiloxane (PDMS), Tissue Engineering, Topography Gradient

Organism: Human

Cell Line: Myoblasts

1523
Responsive exosome nano‐bioconjugates for synergistic cancer therapy

W Nie, G Wu, J Zhang, LL Huang, J Ding, A Jiang, Y Zhang, Y Liu, J Li, K Pu, HY Xie

Angewandte Chemie (Wiley) China, Singapore, 31 October 2019

Nanomedicine

Key words: Exosome, immunotherapy, antibodies, cancer, nanoconjugate

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1524
Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

KQ Fan, YY Li, HL Wang, XT Mao, JX Guo, F Wang, LJ Huang, YN Li, XY Ma, ZJ Gao, W Chen, DD Qian, WJ Xue, Q Cao, L Zhang, L Shen, L Zhang, C Tong, JY Zhong, W Lu, L Lu, KM Ren, G Zhong, Y Wang, M Tang, XH Feng, RJ Chai, J Jin

CELL (Cell Press) China, 31 October 2019

Neuroscience

Key words: T cell, stress, leukotriene B4, anxiety, purine metabolism, amygdala, AdorA1, IRF-1, xanthine

Organism: Mouse

Cell Line: CD4 T Cells

1525
Distribution of Tyrosine‐Hydroxylase‐Immunoreactive Neurons in the Hypothalamus of Tree Shrews

ZH Huang, RJ Ni, PH Luo, JN Zhou

Journal of Comparative Neurology (Wily) China, 31 October 2019

Neuroscience

Key words: Tyrosine hydroxylase, Hypothalamus, Immunohistochemistry, RRID: AB_2201526, Vasopressin, Aromatic L-amino acid decarboxylase

Organism: Tree Shrew

Tissue: Brain

1526
Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model

S Sudirman, CS Lai, YL Yan, HI Yeh, ZL Kong

Scientific Reports (Nature) Taiwan, 23 October 2019

Endocrinology

Key words: Experimental models of disease, Immunology

Organism: Mouse

Tissue: Heart, Kidney

Pathological State: Diabetes

1527
Nasal Pneumococcal Density is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens

E Mitsi, B Carniel, J Reiné, J Rylance, S Zaidi, A Soares-Schanoski, V Connor, A M Collins, A Schlitzer, E Nikolaou, C Solórzano, S Pojar, H Hill, AD Hyder-Wright, KC Jambo, MR Oggioni, M De Ste Croix, SB Gordon, SP Jochems, DM Ferreira

American Journal of Respiratory and Critical Care Medicine (ATS Journals) UK, Brazil, Germany, Malawi, The Netherlands, 18 October 2019

Immunology

Key words: Nasopharygeal colonization, Microaspiration, Alveolar macrophages, Controlled Human Infection model, CD4+ T cells

Organism: Human

Cell Line: BAL Cells

1528
Human Mesenchymal Stem Cell Response to Lactoferrin-based Composite Coatings

M Icriverzi, A Bonciu, L Rusen, LE Sima, S Brajnicov, A Cimpean, RW Evans, V Dinca, A Roseanu

Materials (MDPI) Romania, UK, 18 October 2019

Biomaterials

Key words: mesenchymal stem cells, osteogenic differentiation, lactoferrin, polymer composite

Organism: Human

Cell Line: hMSCs

1529
Facile and efficient encapsulation of antimicrobial peptides via crosslinked DNA nanostructures and their application in wound therapy

S Obuobi, HKL Tay, NDT Tram, V Selvarajan, J Singh Khara, Y Wang, PLR Ee

Journal of Controlled Release (Elsevier) Singapore, 16 October 2019

Nanomedicine

Key words: DNA hydrogel, S. aureus infection, Wound healing, Antimicrobial peptides, Controlled release, Electrostatic interactions

Organism: Mouse

Tissue: Skin

Pathological State: Staphylococcus aureus Infection

1530
Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

MK Graham, J Kim, J Da, JA Brosnan-Cashman, A Rizzo, JA Baena Del Valle, L Chia, M Rubenstein, C Davis, Q Zheng, L Cope, M Considine, MC Haffner, AM De Marzo, AK Meeker, CM Heaphy

Molecular Cancer Research (AACR Publications) USA, 14 October 2019

Oncology

Key words: ATRX, TERC, Telomeres, Alternative lengthening of telomeres, Cancer, Prostate cancer, telomerase, gene knockout, CRISPR/Cas

Organism: Human

Pathological State: Cancer

Cell Line: LAPC-4 Cells

1531
Comparing the Osteogenic Potentials and Bone Regeneration Capacities of Bone Marrow and Dental Pulp Mesenchymal Stem Cells in a Rabbit Calvarial Bone Defect Model

YC Lee, YH Chan, SC Hsieh, WZ Lew, SW Feng

International Journal of Molecular Sciences (MDPI) Taiwan, 10 October 2019

Regenerative Medicine

Key words: mesenchymal stem cells, dental pulp stem cells, bone marrow stem cells, bone regeneration, calvarial defect

Organism: Rabbit

Tissue: Bone

1532
Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis

HT Liu, TE Wang, YT Hsu, CC Chou, KH Huang, CC Hsu, HJ Liang, HW Chang, TH Lee, PS Tsai

Antioxidants (MDPI) Taiwan, 09 October 2019

Biomaterials

Key words: honokiol, cisplatin, kidney injury, oxidative stress, apoptosis, nanotechnology

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

1533
Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β1-42 Oligomers

LS Wang, X Tao, XM Liu, YF Zhou, MD Zhang, YH Liao, RL Pan, Q Chang

Frontiers in Pharmacology (Frontiers Media S.A.) China, 24 September 2019

Pharmacology

Organism: Mouse

Tissue: Brain

1534
Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8

HC Wang, YL Lin, CC Hsu, YJ Chao, YC Hou, TJ Chiu, PH Huang, MJ Tang, LT Chen, YS Shan

Theranostics (NCBI) Taiwan, 23 September 2019

Oncology

Key words: pancreatic cancer, PSC, stiffness, organotypic coculture, PAI-1

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

1535
A Method for Predicting the Success of Pulsinell's Four-Vessel Occlusion Rat Model by LDF Monitoring of Cerebral Blood Flow Decline

W Wang, X Liu, H Lu, L Liu, Y Wang, Y Yu, T Zhang

Journal of Neuroscience Methods (Elsevier) China, 20 September 2019

Neuroscience

Key words: Global cerebral ischemia-reperfusion injury, Laser Doppler flowmetry, Pulsinelli's four-vessel occlusion method, cerebral blood flow decline

Organism: Rat

Tissue: Brain

1536
Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats

CY Chang, HJ Shih, IT Huang, PS Tsai, KY Chen, CJ Huang

International Journal of Molecular Sciences (MDPI) Taiwan, 18 September 2019

Cardiology

Key words: Right heart failure, oxidation, mitochondria, inflammation, inflammasomes, apoptosis

Organism: Rat

Tissue: Lung

Pathological State: Heart Failure, Hypertension

1537
Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model

S Hu, C Sun, B Wang, K Zhou, L Pan, J Shangguan, V Yaghmai, M Figini, Z Zhang

Journal of Vascular and Interventional Radiology (Elsevier) China, 18 September 2019

Oncology

Organism: Rabbit

Tissue: Liver

Pathological State: Cancer

1538
Disruption of mitochondrial homeostasis with artemisinin unravels anti-angiogenesis effects via auto-paracrine mechanisms

KH Tsui, MY Wu, LT Lin, ZH Wen, YH Li, PY Chu, CJ Li

Theranostics (NCBI) Taiwan, USA, 17 September 2019

Endocrinology

Key words: artemisinin, mitochondria, VEGF, angiogenesis, auto-paracrine

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1539
Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation

A Quarta, D Le Blon, T D'aes, Z Pieters, SH Taj, F Miro-Mur, E Luyckx, E Van Breedam, J Daans, H Goossens, S Dewilde, N Hens, V Pasque, AM Planas, M Hoehn, Z Berneman, P Ponsaerts

Brain, Behavior, and Immunity (Elsevier) Belgium, Germany, Spain, The Netherlands, 13 September 2019

Immunology, Neuroscience

Key words: iPSC, Microglia, Macrophages, Stroke, Neuroinflammation, Interleukin (IL) 13, Polarisation, Classical activation, Alternative activation

Organism: Mouse

Tissue: Brain

1540
The Effect of Wharton Jelly-Derived Mesenchymal Stromal Cells and Their Conditioned Media in the Treatment of a Rat Spinal Cord Injury

M Chudickova, I Vackova, L Machova Urdzikova, P Jancova, K Kekulova, M Rehorova, K Turnovcova, P Jendelova, S Kubinova

International Journal of Molecular Sciences (MDPI) Czech Republic, 12 September 2019

Neuroscience

Key words: spinal cord injury, mesenchymal stem cells, Wharton's jelly, conditioned medium, cell secretome, cell therapy

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

1541
Next-generation computational tools for interrogating cancer immunity

F Finotello, D Rieder, H Hackl, Z Trajanoski

Nature Reviews Genetics (Nature) Austria, 12 September 2019

Oncology

Key words: Antigen presentation, Cancer genetics, Cancer genomics, Cancer immunotherapy, Computational biology and bioinformatics, Tumor immunology

1542
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

X Wu, C Lei, T Xia, X Zhong, Q Yang, HB Shu

Nature Communications (Nature) China, 11 September 2019

Immunology

Key words: Bacterial Infection, Innate immune cells, Pattern recognition receptors, Ubiquitylation

Organism: Mouse

Tissue: Lung

1543
Region-specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation

G Gussak, A Pfenniger, L Wren, M Gilani, W Zhang, S Yoo, DA Johnson, A Burrell, B Benefield, G Knight, BP Knight, R Passman, JJ Goldberger, G Aistrup, JA Wasserstrom, Y Shiferaw, R Arora

JCI Insight (American Society of Clinical Investigation) USA, 10 September 2019

Neuroscience

Organism: Dog

Tissue: Heart

1544
Calcium‐sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice

Z Cheng, A Li, CL Tu, C Santa Maria, N Szeto, A Herberger, TH Chen, F Song, J Wang, X Liu, DM Shoback, W Chang

Journal of Bone and Mineral Research (Wiley) USA, 09 September 2019

Osteology

Key words: chondrogenesis, osteogenesis, endochondral bone formation, cartilage, chondrocyte, osteoblast, CaSR knockout, unfixed fracture, fracture healing

1545
Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection

J Kim, Y Moon

Nutrients (MDPI) South Korea, 08 September 2019

Immunology

Key words: Gut health, Probiotics, Caenorhabditis elegans, Epithelial barrier infection

Organism: Mouse

Tissue: Colon

Pathological State: Worm Infestation

1546
Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation

BG Durgin, SA Hahn, HM Schmidt, MP Miller, N Hafeez, I Mathar, D Freitag, P Sandner, AC Straub

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, Germany, 05 September 2019

Cardiology

Organism: Mouse

Tissue: Heart

1547
ATMIN is a tumor suppressor gene in lung adenocarcinoma

H Foster, E Josue Ruiz, C Moore, GWH Stamp, EL Nye, N Li, Y Pan, Y He, J Downward, A Behrens

Cancer Research (AACR Publications) UK, 03 September 2019

Oncology

1548
Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer

TT Wei, YT Lin, SP Tang, CK Luo, CT Tsai, CT Shun, CC Chen

Oncogene (Nature) Taiwan, 02 September 2019

Oncology

Key words: Cancer therapeutic resistance, Tumor angiogenesis

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Cancer

1549
Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models

M Lee, YS Kim, K Lee, M Kang, H Shin, JW Oh, H Koo, D Kim, Y Kim, DS Kong, DH Nam, H Won Lee

Cancers (MDPI) South Korea, 31 August 2019

Oncology

Key words: glioblastoma, patient-derived glioblastoma stem-like cells, semi- and pseudotyped-retroviral replicating vector, dual suicide gene therapy, bystander effect

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1550
The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain

E Nasyrov, KA Nolan, RH Wenger, HH Marti, R Kunze

The FASEB Journal (FASEB) Germany, Switzerland, 30 August 2019

Neuroscience

Key words: PHD, HIF, VEGF, Adrenomedullin, Cerebral angiogenesis

Organism: Mouse

Tissue: Brain

1551
Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics

JWJ Ong, KS Tan, SG Ler, J Gunaratne, H Choi, JE Seet, VTK Chow

Cells (MDPI) Singapore, 26 August 2019

Pulmonology

Key words: influenza, pneumonia, lung regeneration, stem cells, comparative quantification, P63, KRT5, proliferating alveolar type II cells, proteomics

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

1552
Macrophage HIF‐2α regulates tumor‐suppressive Spint1 in the tumor microenvironment

RM Susen, R Bauer, C Olesch, DC Fuhrmann, AF Fink, N Dehne, A Jain, I Ebersberger, T Schmid, B Brüne

Molecular Carcinogenesis (Wiley) Germany, 22 August 2019

Oncology

Key words: HAI‐1, HGF, hypoxia, proliferation, tumor‐associated macrophages

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

1553
Nononcogenic restoration of the intestinal barrier by E. coli–delivered human EGF

M Yu, J Kim, JH Ahn, Y Moon

The Journal of Clinical Investigation (Am Soc Clin Investig) South Korea, 22 August 2019

Microbiology

Organism: Mouse

Tissue: Small Intestine

Pathological State: Colitis

1554
Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity

Z Tang, S Cheng, Y Sun, Y Zhang, X Xiang, Z Ouyang, X Zhu, B Wang, M Hei

Experimental Neurology (Elsevier) China, 20 August 2019

Neuroscience

Key words: Hypoxia-ischemia(HI), Neuroprotection, Brain injuries, Hippocampus, Toll-like receptor 4, Rat model

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

1555
Microstimulation of primate neocortex targeting striosomes induces negative decision-making

S Amemori, K Amemori, T Yoshida, GK Papageorgiou, R Xu, H Shimazu, R Desimone, AM Graybiel

European Journal of Neuroscience (Wiley) USA, 20 August 2019

Neuroscience

Key words: anterior cingulate cortex, approach-avoidance, microstimulation, orbitofrontal cortex, striatum

Organism: Monkey

Tissue: Brain

1556
IL‐10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis

JL Suen, Y Chang, YS Shiu, CY Hsu, P Sharma, CC Chiu, YJ Chen, TC Hour, EM Tsai

The Journal of Pathology (Wiley) Taiwan, 16 August 2019

Reproductive Medicine

Key words: Angiogenesis, Endometriosis, IL-10, Plasmacytoid dendritic cell, Zebrafish

Organism: Human, Mouse

Tissue: Endometrium

Pathological State: Endometriosis

1557
Targeting the IL-17 receptor using liposomal spherical nucleic acids as topical therapy for psoriasis

H Liu, RS Kang, K Bagnowski, JM Yu, S Radecki, WL Daniel, BR Anderson, S Nallagatla, A Schook, R Agarwal, DA Giljohann, AS Paller

Journal of Investigative Dermatology (Elsevier) USA, 15 August 2019

Dermatology

Pathological State: Psoriasis

1558
JAK‐STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression

J Mohrherr, M Haber, K Breitenecker, P Aigner, S Moritsch, V Voronin, R Eferl, R Moriggl, D Stoiber, B Győrffy, L Brcic, V László, B Döme, J Moldvay, K Dezső, M Bilban, H Popper, HP Moll, E Casanova

International Journal of Cancer (Wiley) Austria, Hungary, 12 August 2019

Oncology

Key words: non-small cell lung cancer, lung adenocarcinoma (AC), Kirsten rat sarcoma viral proto-oncogene (K-RAS), Janus kinase (JAK), ruxolitinib, cell-line derived xenografts, genetically engineered mouse models, tumor microenvironment (TME), tumor promotinginflammation

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

1559
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway

P Guan, ZM Sun, N Wang, J Zhou, LF Luo, YS Zhao, ES Ji

Life Science (Elsevier) China, 11 August 2019

Cardiology

Key words: Resveratrol, Chronic intermittent hypoxia, Cardiac hypertrophy, mTOR

Organism: Rat

Tissue: Heart

Pathological State: Cardiac Hypertrophy

1560
Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys

S Taylor, K Pieri, P Nanni, J Tica, J Barratt, A Didangelos

Journal of Autoimmunity (Elsevier) UK, 09 August 2019

Immunology

Key words: IgA nephropathy (IgAN), PEBP4, Urine, Proteomics, Biomarker, B-Cells

Organism: Human

Tissue: Kidney

Pathological State: IgA nephropathy

1561
Antibiotics drive microbial imbalance and vitiligo development in mice

ER Dellacecca, C Cosgrove, Z Mukhatayev, S Akhtar, VH Engelhard, AW Rademaker, K Knight, IC Le Poole

Journal of Investigative Dermatology (Elsevier) USA, Kazakhstan, 09 August 2019

Dermatology

Key words: Vitiligo, Microbiome, Pseudomonas, T cells

Organism: Mouse

Tissue: Small Intestine, Colon

Pathological State: Vitiligo

1562
Overexpression of Histone H3 Lysine 27 Trimethylation Is Associated with Aggressiveness and Dedifferentiation of Thyroid Cancer

CC Tsai, MN Chien, YC Chang, JJ Lee, SH Dai, SP Cheng

Endocrine Pathology (Springer) Taiwan, 08 August 2019

Oncology

Key words: H3K27me3, EZH2, Thyroid cancer, Immunohistochemistry

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

1563
Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15

Y Guo, JL Ayers, KT Carter, T Wang, SK Maden, D Edmonds, PP Newcomb, C Li, C Ulrich, M Yu, WM Grady

Aging Cell (Wiley) USA, 06 August 2019

Cell Biology

Key words: Colon organoids, Colorectal cancer, GDF15, microenivronment, senescence

Organism: Human

Tissue: Colon

Pathological State: Cancer

1564
Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment

JY Chen, YS Lai, PY Chu, SH Chan, LH Wang, WC Hung

Cancers (MDPI) Taiwan, 06 August 2019

Oncology

Key words: vascular endothelial growth factor-C, CXC chemokine receptor 2, lymphovascular niche, myeloid-derived suppressor cells

Organism: Human

Tissue: Breast

Pathological State: Cancer

1565
Analysis of Telomere Lengths in p53 Signatures and Incidental Serous Tubal Intraepithelial Carcinomas Without Concurrent Ovarian Cancer

S Asaka, C Davis, SF Lin, TL Wang, CM Heaphy, IM Shih

The American journal Surgical Pathology (Wolters Kluwer) USA, 01 August 2019

Oncology

Key words: ovarian cancer precursor, fallopian tube, p53 signature, serous tubal intraepithelial carcinoma, telomere

1566
Increased ILC3s associated with higher levels of IL-1 aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

Tzu‐Yi Chan, Chia‐Liang Yen, Ya‐Fang Huang, Pei‐Chi Lo, Peter A Nigrovic, Chia‐Ying Cheng, Wei‐Zhi Wang, Szu‐Yu Wu, Chi‐Chang Shieh

European Journal of Immunology (Wiley) Taiwan, Japan, USA, 26 July 2019

Rheumatology

Key words: Innate lymphoid cells, Chronic granulomatous disease, NADPH oxidase, Reactive oxygen species, Serum-induced arthritis

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Arthritis

1567
Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns

YN Yang, YCSH Yang, IH Lin, YY Chen, HY Lin, CY Wu, YT Su, YJ Yang, SN Yang, JL Suen

Food and Chemical Toxicology (Elsevier) Taiwan, USA, 26 July 2019

Toxicology

Key words: Di-(2-ethylhexyl) phthalate, Intravenous infusion, Microbiota, Anti-HBsAg-IgM, Newborn

1568
An Amyloid-β Targeting Chemical Exchange Saturation Transfer Probe for In Vivo Detection of Alzheimer's Disease

R Wang, C Wang, Z Dai, Y Chen, Z Shen, G Xiao, Y Chen, JN Zhou, Z Zhuang, R Wu

ACS Chemical Neuroscience (ACS Publications) China, 25 July 2019

Neuroscience

Key words: Alzheimer's disease, Amyloid-β, Magnetic resonance imaging, Chemical exchange saturation transfer, Angiopep-2

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

1569
Synergistic effect of NELL-1 and an ultra-low dose of BMP-2 on spinal fusion

Miss Ling Liu, Dr Wing Moon Raymond Lam, Mrs Mathanapriya Naidu Zheng Yang, Dr Ming Wang, Dr Xiafei Ren, Dr Tao Hu, Kumarsing Amit Ramruttun, Prof Kang Ting, Prof James Cho-Hong Goh, Prof Hee Kit Wong

Tissue Engineering Part A (Mary Ann Liebert Inc.) Singapore, China, 24 July 2019

Regenerative Medicine

Organism: Pig

Cell Line: BMSC

1570
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci & Lucia Di Marcotullio

Nature Communications (Nature) Italy, France, USA, UK, 24 July 2019

Oncology

Key words: Cancer, Molecular biology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1571
DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing

Huafeng Zhang, Songge Xing, Zhaoyong Li, Wenhao Ma, Xiaoping He, Shengqi Shen, Haoran Wei, Shi-Ting Li, Ying Shu, Linchong Sun, Xiuying Zhong, Yuhao Huangfu, Lanhong Su, Junru Feng, Xiaozhang Zhang, Ping Gao and Wei-Dong Jia

Cancer Research (AACR Publications) China, 22 July 2019

Oncology

Key words: HCC, DIS3L2, hnRNP U, Alternative splicing, Rac1b

Organism: Human

Tissue: Liver

Pathological State: Cancer

1572
Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus

I Simitsidellis, AE Zufiaurre, O Kelepouri, Elisabeth O'Flaherty, Douglas A Gibson, Philippa T K Saunders

Journal of Endocrinology (bioscientifica) Ireland, 18 July 2019

Reproductive Medicine

Key words: Uterus, Endometrium, Androgen, SARM, Andarine, GTx-024, Enobosarm, 15 Ostarine, Danazol, DHT

Organism: Mouse

Tissue: Uterus

1573
Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

CY Hung, TI Hsu, JY Chuang, TP Su, WC Chang, JJ Hung

Molecular Neurobiology (Springer) Taiwan, USA, 18 July 2019

Neuroscience

Key words: Sp1, Astrocyte, Neurite outgrowth, Synaptogenesis

Organism: Mouse

Tissue: Brain

1574
Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction

TM Hofbauer, A Mangold, T Scherz, V Seidl, A Panzenböck, AS Ondracek, J Müller, M Schneider, T Binder, L Hell, IM Lang

Basic Research in Cardiology (Springer) Austria, 16 July 2019

Cardiology

Key words: ST-segment elevation myocardial infarction, Neutrophil extracellular traps, Fibrocytes Thrombosis

Organism: Human

Tissue: Heart

1575
Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface

CM Weight, C Venturini, S Pojar, SP Jochems, J Reiné, E Nikolaou, C Solórzano, M Noursadeghi, JS Brown, DM Ferreira, RS Heyderman

Nature Communications (Nature) UK, 16 July 2019

Microbiology, Immunology

Key words: Infection, Innate immunity, Pathogens, Respiratory tract diseases

Organism: Human

Pathological State: Streptococcus Infection

Cell Line: Mucosal cells

1576
B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease

E Della-Torre, E Rigamonti, C Perugino, S Baghai-Sain, N Sun, N Kaneko, T Maehara, L Rovati, M Ponzoni, R Milani, M Lanzillotta, V Mahajan, H Mattoo, I Molineris, V Deshpande, JH Stone, M Falconi, AA Manfredi, S Pillai

Journal of Allergy and Clinical Immunology (Elsevier) Italy, USA, Japan, 15 July 2019

Allergy Research

Key words: IgG4, IgG4-related disease, B cells, plasmablasts, fibrosis, fibroblasts, rituximab, lysyl oxidase homolog 2, plateletderived growth factor

Organism: Human

Tissue: Pancreas, Lymphoid Tissue,

Pathological State: IgG4-Related Disease

1577
Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond

TB Steinbichler, D Savic, D Dejaco, A Romani, B Kofler, II Skvortsova, H Riechelmann, J Dudas

Cancer Microenvironment (Springer) Austria, 11 July 2019

Oncology

Key words: IL-6, EMT, JAK/STAT3/Snail signalling, radiochemotherapy, therapy resistance, conditioned medium

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

1578
The Lymphoma-Associated Macrophages-To-Hodgkin-Reed-Sternberg Cells Ratio Is A Poor Prognostic Factor In Classic Hodgkin Lymphoma Patients

V Procházka, T Papajík, T Dýšková, M Dihel, S Brychtová, Z Prouzová, E Kriegová, M Lukášová, V Hanáčková

Clinical Lymphoma Myeloma and Leukemia (Elsevier) Czech Republic, 05 July 2019

Oncology

Key words: Hodgkin lymphoma, macrophage, prognosis, microenvironment

Organism: Human

Pathological State: Cancer

1579
miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

HY Chen, YD Lang, HN Lin, YR Liu, CC Liao, A Wendindondé Nana, Y Yen, R-Hwa Chen

Scientific Reports (Nature) Taiwan, 04 July 2019

Oncology

Key words: Colon cancer, Metastasis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1580
Entrapment of N-Hydroxyphthalimide Carbon Dots in Different Topical Gel Formulations: New Composites with Anticancer Activity

CL Savin, C Tiron, E Carasevici, CS Stan, SA Ibanescu, BC Simionescu, CA Peptu

Pharmaceutics (MDPI) Romania, 01 July 2019

Oncology

Key words: composite, N-hydroxyphthalimide, carbon dots, polymer gels, antitumoral activity

Organism: Human

Cell Line: MDA-MB-231 cells

1581
Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

Tetsuya Akiyama, Naoki Suzuki, Mitsuru Ishikawa, Koki Fujimori, Takefumi Sone, Jiro Kawada, Ryo Funayama, Fumiyoshi Fujishima, Shio Mitsuzawa, Kensuke Ikeda, Hiroya Ono, Tomomi Shijo, Shion Osana, Matsuyuki Shirota, Tadashi Nakagawa, Yasuo Kitajima, Ayumi Nishiyama, Rumiko Izumi, Satoru Morimoto, Yohei Okada, Takayuki Kamei, Mayumi Nishida, Masahiro Nogami, Shohei Kaneda, Yoshiho Ikeuchi, Hiroaki Mitsuhashi, Keiko Nakayama, Teruo Fujii, Hitoshi Warita, Hideyuki Okano, Masashi Aoki, Masashi Aoki

EBioMedicine (THE LANCET) Japan, 29 June 2019

Neuroscience

Key words: Amyotrophic lateral sclerosis (ALS), Fused in sarcoma (FUS), Axon branching, Fos-B, Nerve organoid, Human-induced pluripotent stem cell (hiPSC)-derived motor neuron

Organism: Human

Tissue: Spinal Cord

Pathological State: Amyotrophic Lateral Sclerosis

1582
Fbxw7 increases CCL2/7 in CX3CR1hi macrophages to promote intestinal inflammation

Jia He, Yinjing Song, Gaopeng Li, Peng Xiao, Yang Liu, Yue Xue, Qian Cao, Xintao Tu, Ting Pan, Zhinong Jiang, Xuetao Cao, Lihua Lai, and Qingqing Wang

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 27 June 2019

Immunology

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

1583
Amelioration of Experimentally Induced Arthritis by Reducing Reactive Oxygen Species Production through the Intra-Articular Injection of Water-Soluble Fullerenol

WS Kuo, CT Weng, JH Chen, CL Wu, AL Shiau, JL Hsieh, EC So, PT Wu, SY Chen

Nanomaterials (MDPI) China, Taiwan, 23 June 2019

Nanomedicine

Key words: experimental arthritis, intra-articular injection, reactive oxygen species, rheumatoid arthritis, water-soluble fullerenol

Organism: Rat

Tissue: Bone, Connective Tissue

Pathological State: Rheumatoid Arthritis

1584
Cytotoxic T-cells and their activation status are independent prognostic markers in meningiomas

Carmen Rapp, Steffen Dettling, Fang Liu, Anna Theresa Ull, Rolf Warta, Christine Jungk, Saskia Roesch, Andreas Mock, Felix Sahm, Melissa Schmidt, Gerhard Jungwirth, Klaus Zweckberger, Katrin Lamszus, Konstaninos Gousias, Almuth F Kessler, Niels Grabe, Mario Löhr, Ralf Ketter, Steffi Urbschat, Christian Senft, Manfred Westphal, Amir Abdollahi, Jürgen Debus, Andreas von Deimling, Andreas Unterberg, Matthias Simon and Christel C Herold-Mende

Clinical Cancer Research (AACR Publications) Germany, 21 June 2019

Immunology, Oncology

Key words: Clinically aggressive meningioma, T-cell infiltration, primary and recurrent tumors TILs, PD-1

Organism: Human

Tissue: Brain

Pathological State: Cancer

1585
Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets

Barbara Thaler, Nagyung Baik, Philipp J Hohensinner, Johanna Baumgartner, Adelheid Panzenböck, Stefan Stojkovic, Svitlana Demyanets, Ihor Huk, Gersina Rega-Kaun, Christoph Kaun, Manfred Prager, Michael B Fischer, Kurt Huber, Walter S Speidl, Robert J Parmer, Lindsey A Miles, Johann Wojta

Blood (American Society of Hematology) Austria, USA, 20 June 2019

Cardiology

Organism: Human

Tissue: Adipose Tissue

1586
Specific inhibition of the classical complement pathway prevents C3 deposition along the dermal-epidermal junction in bullous pemphigoid

Patricia Colchete Freire, Cristina Herraez Muñoz, Ulla Derhaschnig, Christian Schoergenhofer, Christa Firbas, Graham C Parry, Sandip Panicker, James C Gilbert, Georg Stingl, Bernd Jilma, Peter Maximilian Heil

Journal of Investigative Dermatology (Elsevier) Austria, USA, 20 June 2019

Dermatology

1587
Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

C Yang, P Sun, M Deng, P Loughran, W Li, Z Yi, S Li, XH Zhang, J Fan, TR Billar, MJ Scott

Cell Death & Disease (Nature) USA, China, 17 June 2019

Hepathology

Key words: Cell death and immune response, Innate immunity

Organism: Mouse

Tissue: Liver

Pathological State: Liver Injury

1588
C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice

Tobias Ackermann, Götz Hartleben, Christine Müller, Guido Mastrobuoni, Marco Groth, Britt A Sterken, Mohamad A Zaini, Sameh A Youssef, Hidde R Zuidhof, Sara R Krauss, Gertrud Kortman, Gerald de Haan, Alain de Bruin, Zhao-Qi Wang, Matthias Platzer, Stefan Kempa & Cornelis F Calkhoven

Nature Communications Biology (Nature) The Netherlands, Germany, 14 June 2019

Oncology

Key words: Cancer metabolism, Cell growth

Organism: Mouse

Tissue: Bone Marrow

1589
Fc glycan-mediated regulation of placental antibody transfer

Madeleine F Jennewein, Ilona Goldfarb, Sepideh Dolatshahi, Cormac Cosgrove, Francesca J Noelette, Marina Krykbaeva, Jishnu Das, Aniruddh Sarkar, Matthew J Gorman, Stephanie Fischinger, Carolyn M Boudreau, Joelle Brown, Jennifer H Cooperrider, Jasneet Aneja, Todd J Suscovich, Barney S Graham, Georg M Lauer, Tessa Goetghebuer, Arnaud Marchant, Douglas Lauffenburger, Arthur Y Kim, Laura E Riley, Galit Alter

CELL (Cell Press) USA, Belgium, 13 June 2019

Reproductive Medicine, Immunology

Key words: antibody functionality, antibody glycosylation, trans-placental transfer, maternal vaccination, ADCC, neonatal immunology

Organism: Human

Tissue: Placenta

1590
The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism

RL Konger, E Derr-Yellin, N Ermatov, L Ren, RP Sahu

Molecules (MDPI) USA, 11 June 2019

Oncology, Immunology

Key words: peroxisome proliferator activated receptor gamma, rosiglitazone, T-cells, myeloid cells, anti-tumor immunity

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1591
Optimisation of multiplex immunofluorescence for a non-spectral fluorescence scanning system

CC Anyaegbu, TF Lee-Pullen, TJ Miller, TN Abel, CF Platell, MJ McCoy

Journal of Immunological Methods (Elsevier) Australia, 08 June 2019

Bioimaging

Key words: Fluorescence microscopy, Imaging, Immunohistochemistry, T cells, Colorectal

Organism: Human

Tissue: Colon

1592
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

Amanda Ardain, Racquel Domingo-Gonzalez, Shibali Das, Samuel W Kazer, Nicole C Howard, Alveera Singh, Mushtaq Ahmed, Shepherd Nhamoyebonde, Javier Rangel-Moreno, Paul Ogongo, Lan Lu, Duran Ramsuran, Maria de la Luz Garcia-Hernandez, Tyler K Ulland, Matthew Darby, Eugene Park, Farina Karim, Laura Melocchi, Rajhmun Madansein, Kaylesh Jay Dullabh, Micah Dunlap, Nancy Marin-Agudelo, Takashi Ebihara, Thumbi Ndung'u, Deepak Kaushal, Alexander S Pym, Jay K Kolls, Adrie Steyn, Joaquín Zúñiga, William Horsnell, Wayne M Yokoyama, Alex K Shalek, Henrik N Kløverpris, Marco Colonna, Alasdair Leslie & Shabaana A Khader

Nature (Nature) South Africa, USA, Kenya, Mexico, UK, Denmark, 05 June 2019

Immunology

Key words: Innate lymphoid cells, Tuberculosis

Organism: Human

Tissue: Lung

Pathological State: Tuberculosis

1593
Role of the PI3K‑mTOR autophagy pathway in nerve damage in rats with intermittent hypoxia‑aggravated whole brain ischemia

X Guo, Y Liu, Y Zhao, R Fan, Y Bai, X Guo, J Li, CX Chen

Molecular Medicine Reports (Spandidos Publications) China, 04 June 2019

Neuroscience

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

1594
Heat-killed Mycobacterium tuberculosis prime-boost vaccination induces myeloid-derived suppressor cells with spleen dendritic cell-killing capability

Eliana Ribechini, Ina Eckert, Andreas Beilhack, Nelita Du Plessis, Gerhard Walzl, Ulrike Schleicher, Uwe Ritter, and Manfred B Lutz

The Journal of Clinical Investigation (American Society for Clinical Investigation) Germany, South Africa, 04 June 2019

Immunology

Organism: Mouse

Cell Line: BM-MDSCs and BM-DCs cell

1595
Abnormal expression of b10 cell frequencies: possible relation to pathogenesis and disease severity of aplastic anemia

L Gu, B Fu, X Sui, H Xu

Revista da Associação Médica Brasileira (SciELO Brasil) China, 03 June 2019

Hematology

Key words: Anemia, Aplastic, B-Lymphocytes, Regulatory, Interleukin-10

Organism: Human

Cell Line: Bone marrow-derived mononuclear cells

1596
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Yueming Zhu, Xianghui Zou, Angela E Dean, Joseph O' Brien, Yucheng Gao, Elizabeth L Tran, Seong-Hoon Park, Guoxiang Liu, Matthew B Kieffer, Haiyan Jiang, Melissa E Stauffer, Robert Hart, Songhua Quan, Karla J F Satchell, Nobuo Horikoshi, Marcelo Bonini, David Gius

Nature Communications (Nature) USA, South Korea, 03 June 2019

Oncology

Key words: Breast cancer, Cancer, Enzyme mechanisms

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

1597
Micro RNA‐133 Suppresses ZFHX 3‐dependent Atrial Remodeling and Arrhythmia

WL Cheng, YH Kao, TF Chao, YK Lin, SA Chen, YJ Chen

Acta Physiologica (Wiley) Taiwan, 01 June 2019

Cardiology

Key words: atrial ectopy, cardiac remodelling, connexin43, MicroRNA‐133, Wnt/calcium signalling, ZFHX3

Organism: Mouse

Tissue: Heart

Pathological State: Arrhythmia

1598
AIF-regulated oxidative phosphorylation supports lung cancer development

Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J Cronin, Zhigang She, Franz Quehenberger, Helmut Popper, Lukas Kenner, Jody J Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer & Josef M Penninger

Cell Research (Nature) China, Austria, France, Germany, Canada, Belgium, Sweden, 27 May 2019

Oncology

Key words: Mechanisms of disease, Non-small-cell lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

1599
Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

H Tsugawa, C Kato, H Mori, J Matsuzaki, K Kameyama, H Saya, M Hatakeyama, M Suematsu, H Suzuki

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) Japan, 27 May 2019

Oncology, Microbiology

Key words: Autophagy, CagA, Cancer Stem Cells, CD44v9, Eradication Therapy

Organism: Human

Tissue: Stomach

Pathological State: Cancer

1600
LINGO-1 deficiency promotes nerve regeneration through reduction of cell apoptosis, inflammation, and glial scar after spinal cord injury in mice

LJ Huang, G Li, Y Ding, JH Sun, TT Wu, W Zhao, YS Zeng

Experimental Neurology (Elsevier) China, 25 May 2019

Neuroscience

Key words: LINGO-1 knockout, Spinal cord injury, Cell apoptosis, Inflammation, Glial scar, Nerve regeneration

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

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