Customer Publications (A total of 3186 papers published)
Effect of high fat diet on the severity and repair of lung fibrosis in mice
Stem Cells and Development (Mary Ann Liebert Inc.) Japan, 16 July 2021
Endocrinology, Pulmonology
Key words: High Fat Diet, Fibrosis, Alveolar Type-2 Cells, Bronchioalveolar Stem Cells, Fatty Acid Oxidation [more]
Organism: Mouse
Tissue: Lung
Pathological State: Pulmonary Fibrosis
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells
JCI Insight (The American Society for Clinical Investigation) Denmark, South Africa, USA, 12 July 2021
SARS-CoV-2
Key words: AIDS/HIV, Covid-19 [more]
Organism: Human
Tissue: Colon
Pathological State: HIV Infection
Down-regulation of A20 promotes immune escape of lung adenocarcinomas
Science Translational Medicine (AAAS) Austria, USA, Hungary, 07 July 2021
Oncology, Pulmonology
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle
International Journal of Molecular Sciences (MDPI) Italy, UK, Austria, 06 July 2021
Osteology
Key words: Skeletal Muscle, Satellite Cells, Myogenesis, Calcium-Sensing Receptor, G Protein-Coupled Receptors [more]
Organism: Human
Tissue: Muscle
Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM
Cells (MDPI) The Netherlands, Australia, Indonesia, Canada, 29 June 2021
Pulmonology
Key words: Extracellular Matrix, Senescence, Idiopathic Pulmonary Fibrosis, Proinflammatory, Profibrotic [more]
Organism: Human
Cell Line: Primary human lung fibroblasts
Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo
Stem Cell Research & Therapy (BMC) Taiwan, Japan, 29 June 2021
Neuroscience
Key words: Antioxidation, Cerebellum, Granule Cells, Jun Dimerization Protein 2 (Jdp2), Reactive Oxygen Species (ROS) [more]
Organism: Mouse
Tissue: Brain
Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma
Frontiers in Oncology (Frontiers Media S.A.) China, 29 June 2021
Oncology
Key words: Extramedullary Multiple Myeloma, MIF, Immunohistochemistry Staining, Xenograft Models, Single-Cell Sequencing [more]
Organism: Human
Tissue: Bone Marrow
Pathological State: Cancer
Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy
Aging (Impact Journals) China, 27 June 2021
Cardiology
Key words: Cardiac Senescence, Telomere Length Shortening, Mitophagy, Sirt1, Sirt6, pAMPK [more]
Organism: Mouse
Tissue: Heart
Inhibition of endoplasmic reticulum stress-related autophagy attenuates MCLR-induced apoptosis in zebrafish testis and mouse TM4 cells
Ecotoxicology and Environmental Safety (Elsevier) China, 25 June 2021
Toxicology
Key words: MCLR, Autophagy, Endoplasmic Reticulum Stress, Apoptosis, Zebrafish [more]
Organism: Zebrafish
Tissue: Testis
Magneto-Activation and Magnetic Resonance Imaging of Natural Killer Cells Labeled with Magnetic Nanocomplexes for the Treatment of Solid Tumors
ACS NANO (ACS Publications) USA, 24 June 2021
Nanomedicine
Key words: Natural Killer Cell, Magneto-Activation, Nanocomplexes, Cell Labeling, Cancer Therapy [more]
Organism: Rat
Tissue: Liver
Pathological State: Cancer
Omega-Class Glutathione Transferases of Carcinogenic Liver Fluke, Clonorchis sinensis, Modulate Apoptosis and Differentiation of Host Cholangiocytes
Antioxidants (MDPI) South Korea, 24 June 2021
Parasitology
Key words: Clonorchis Sinensis, Omega-Class Glutathione Transferase, Cholangiocyte, Oxidative Stress, Programmed Cell Death, Cell Differentiation, Protein Kinase, Gene Regulation [more]
Organism: Rat
Tissue: Liver
Pathological State: Clonorchis sinensis Infection
Hematological consequences of malaria in mice previously treated for visceral leishmaniasis
Wellcome Open Research (Wellcome Open Research) UK, 18 June 2021
Parasitology
Key words: visceral leishmaniasis, malaria, mouse models, hematology, chemotherapy, coinfection [more]
Organism: Mouse
Tissue: Liver
Pathological State: Leishmaniasis
Investigating Transcriptional Dynamics Changes and Time-Dependent Marker Gene Expression in the Early Period After Skeletal Muscle Injury in Rats
Frontiers in Genetics (Frontiers Media S.A.) China, 17 June 2021
Genetics
Key words: Time-Series RNA-Seq, Gene Expression and Regulation Landscape, Time-Related Biomarkers, Transcriptional Dynamics, Skeletal Muscle Injury [more]
Organism: Rat
Tissue: Muscle
Pathological State: Muscle Injury
DNA polymerase β deficiency promotes the occurrence of esophageal precancerous lesions in mice
Neoplasia (Elsevier) China, 15 June 2021
Oncology
Key words: Polβ, NMBA, Esophageal Precancerous Lesion [more]
Organism: Mouse
Tissue: Esophagus
Pathological State: Cancer
Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness
eLife (eLife Sciences Publications) USA, 11 June 2021
Oncology
Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice
Journal of Proteome Research (ACS Publications) USA, 09 June 2021
Cell Biology
Key words: Mass Spectrometry, Peptides and Proteins, Central Nervous System, Rodent Models, Endocytosis [more]
Organism: Mouse
Tissue: Brain
A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL‐40‐IL‐13 Receptor α2 Axis
Arthritis & Rheumatology (Wiley) The Netherlands, Malaysia, 08 June 2021
Rheumatology
Organism: Human
Cell Line: Human microvascular endothelial cells
A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer
Cancers (MDPI) Taiwan, 08 June 2021
Oncology
Key words: CCNF, FBXL8, FZR1, RRM2, E3 Ubiquitin Ligase, Breast Cancer, Metastasis [more]
Organism: Human
Cell Line: BRCA cells
Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma
Molecular Systems Biology (EMBO press) USA, UK, 08 June 2021
Neuroscience
Organism: Human
Cell Line: U5-HNSCs
Determining optimal clinical target volume margins in high-grade glioma based on microscopic tumor extension and magnetic resonance imaging
Radiation Oncology (BMC) China, 07 June 2021
Oncology
Key words: High-Grade Glioma, Macropathology, Microscopic Extension, Predictive Model, Clinical Target Volume, Radiotherapy [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer
Cell Death Discovery (Nature) China, 05 June 2021
Oncology
Key words: Cancer Microenvironment [more]
Organism: Mouse
Tissue: Ovaries
Pathological State: Cancer
Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment
Brain (Oxford Academic) Taiwan, France, 04 June 2021
Neuroscience
Key words: Human Platelet Lysate, Traumatic Brain Injury, Neuroprotection, Neurorestoration, Neurotrophins [more]
Organism: Mouse
Tissue: Brain
Pathological State: Traumatic Brain Injury
MoNuSAC2020: A Multi-organ Nuclei Segmentation and Classification Challenge
IEEE Transactions on Medical Imaging (IEEE Xplore) USA, Canada, India, The Netherlands, China, USA, China, Iran, Russia, Austria, Taiwan, UAE, Slovakia, UK, 04 June 2021
Medical Image Analysis
Key words: Multi-Organ Dataset, Nucleus Classification, Computational Pathology, Instance Segmentation, Panoptic Quality
Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice
PLoS One (PLOS) Germany, 04 June 2021
Physiology
Key words: Exercise, Running, Arrhythmia, Mouse Models, Heterozygosity, Phosphorylation, Physical Activity, Sedentary Behavior [more]
Organism: Mouse
Tissue: Heart
Synthetic Fibrin-Derived Bβ15-42 Peptide Delays Thrombus Resolution in a Mouse Model
Arteriosclerosis, Thrombosis and Vascular Biology (American Heart Association) Austria, Germany, 03 June 2021
Cardiology
Key words: Macrophages, Microvessels, Monocyte, Plasma, Venous Thrombosis [more]
Organism: Human
Cell Line: Dermal microvascular endothelial cells
Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study
Current Issues in Molecular Biology (MDPI) Romania, 02 June 2021
Oncology
Key words: AKT, Breast Cancer, EMT, HIF, Sevoflurane, Vimentin [more]
Organism: Human
Pathological State: Cancer
Cell Line: MCF-10A cells
Lactate modulates cellular metabolism through histone lactylation-mediated gene expression in non-small cell lung cancer
Frontiers in Oncology (Frontiers Media S.A.) China, 02 June 2021
Oncology
Key words: Lactate, Lactylation, Metabolism, Gene Expression, Non-Small Cell Lung Cancer [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Disruption of Tfh: B cell interactions prevents antibody-mediated rejection in a kidney transplant model in rats: impact of calcineurin inhibitor dose
Frontiers in Immunology (Frontiers Media S.A.) Germany, 31 May 2021
Transplantation Medicine
Key words: Antibody-Mediated Rejection, Donor-Specific Antibodies, Kidney Transplantation, T Follicular Helper Cells, B Cell Activation, Calcineurin Inhibitor [more]
Organism: Rat
Tissue: Kidney
Pathological State: Organ Transplantation
Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation
Biochemical Pharmacology (Elsevier) Austria, 28 May 2021
Endocrinology
Organism: Mouse
Tissue: Blood Vessels
Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma
Biomedicine & Pharmacotherapy (Elsevier) Taiwan, UK, 27 May 2021
Pulmonology
Key words: Chronic Obstructive Asthma, Airway Fibrosis, ADAM17, EGFR, Human Lung Fibroblasts [more]
Organism: Mouse
Tissue: Lung
Pathological State: Pulmonary Fibrosis
Investigating the Impact of the Bit Depth of Fluorescence-Stained Images on the Performance of Deep Learning-Based Nuclei Instance Segmentation
Diagnostics (MDPI) Austria, UK, 27 May 2021
Medical Image Analysis
Key words: Bit Depth, Nuclei Segmentation, Fluorescence Staining, Medical Image Analysis, Computational Pathology, Deep Learning
Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection
Frontiers in Immunology (Frontiers Media S.A.) USA, Germany, 26 May 2021
Immunology
Key words: Innate Immunity, T Cells, HIV-1, HuBLT, BLT, Humanized Mice [more]
Organism: Mouse
Tissue: Spleen, Thymus
Pathological State: HIV Infection
Magneto Mitochondrial Dysfunction Mediated Cancer Cell Death Using Intracellular Magnetic Nano-Transducers
Biomaterials Science (Royal Society of Chemistry) USA, South Korea, 26 May 2021
Oncology
Organism: Rat
Tissue: Liver
Pathological State: Cancer
Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response
Biomedicines (MDPI) Czech Republic, USA, 24 May 2021
Regenerative Medicine, Neuroscience
Key words: Spinal Cord Injury, mTOR, Rapamycin, pp242, Dual Inhibition, Autophagy, Inflammation [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Remdesivir Alleviates Acute Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome
Frontiers in Immunology (Frontiers Media S.A.) China, USA, 21 May 2021
Immunology, Pharmacology
Key words: Remdesivir, NLRP3 Inflammasome or NOD-, LRR-, Pyrin Domain-Containing Protein 3 (NLRP3)Inflammasome, NF-κB, Macrophage, Acute Kidney Injury [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Acute Kidney Injury
Evaluation of a Novel Tilapia-skin Acellular Dermis Matrix Rationally Processed for Enhanced Wound Healing
Materials Science and Engineering: C (Elsevier) China, 21 May 2021
Tissue Engineering
Key words: Tilapia Skin, Decellularization, Wound Healing, Degradation, Re-Epithelialization [more]
Organism: Pig, Rat
Tissue: Skin
Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-Based Novel Therapy against Endotoxemia in Mice
Journal of Personalized Medicine (MDPI) Taiwan, Vietnam, 20 May 2021
Pharmacology
Key words: TNF-α, IL-1β, IL-6, Necroptosis, Pyroptosis, Apoptosis, Liver [more]
Organism: Mouse
Tissue: Liver
Pathological State: Endotoxemia
Piezo2 downregulation via the Cre-lox system affects aqueous humor dynamics in mice
Molecular Vision (Emory University) China, 20 May 2021
Ophthalmology
Organism: Human
Tissue: Eye
Tissue image cytometry
Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 1 (IOP Publishing) Austria, 15 May 2021
Medical Image Analysis
Modulation of the anticancer activities of paclitaxel by Cremophor micelles
International Journal of Pharmaceutics (Elsevier) Taiwan, 14 May 2021
Oncology
Key words: Cell Cycle, Cremophor, Micelle, Paclitaxel, Polyploidy [more]
Organism: Mouse
Tissue: Allograft Tumor
Pathological State: Cancer
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo
Oncogenesis (Nature) Taiwan, China, 13 May 2021
Oncology
Key words: Drug Development, Drug Discovery and Development [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Intravital mesoscopic fluorescence molecular tomography allows non-invasive in vivo monitoring and quantification of breast cancer growth dynamics
Communications Biology (Nature) Turkey, Germany, 11 May 2021
Oncology
Key words: 3-D Reconstruction, Fluorescence Imaging, Molecular Imaging, Optical Imaging, Time-Lapse Imaging [more]
Organism: Mouse
Tissue: Breast
Pathological State: Cancer
Machine-perfused donor kidneys as a source of human renal endothelial cells
American Journal of Physiology (APS Journals) The Netherlands, 11 May 2021
Nephrology
Key words: Donation, Endothelial Cells, Kidney, Machine Perfusion, Perfusate, Transplantation [more]
Organism: Human
Pathological State: Organ Transplantation
Cell Line: Cells derived from machine perfusates after kidney donation
Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures
Brain Stimulation (Elsevier) Taiwan, USA, 11 May 2021
Neuroscience
Key words: Seizure, Epilepsy, Electroencephalography (EEG), Oscillation, Interictal Spikes, Transcranial Direct Current Stimulation (tDCS) [more]
Organism: Rat
Tissue: Brain
Pathological State: Chronic Seizures
Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation
Communications Biology (Nature) South Korea, 10 May 2021
Oncology
Key words: Cancer Microenvironment, Pharmacodynamics [more]
Organism: Mouse
Tissue: Colon
Pathological State: Cancer
Dystrophin Deficiency Causes Progressive Depletion of Cardiovascular Progenitor Cells in the Heart
International Journal of Molecular Sciences (MDPI) Czech Republic, France, 10 May 2021
Cardiology
Key words: Duchenne Muscular Dystrophy, mdx Mouse, Cardiovascular Progenitors, C-Kit, Genomic Instability, Dilated Cardiomyopathy [more]
Organism: Mouse
Tissue: Heart
Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase
Bioscience Reports (Portland Press) China, 10 May 2021
Oncology
Key words: Human Osteosarcoma, Metastasis, Glycogen Synthase Kinase 3β [more]
Organism: Human
Tissue: Bone
Pathological State: Cancer
Neutralizing Anti-Interleukin-1 Receptor-Antagonist Autoantibodies Induce Inflammatory and Fibrotic Mediators in IgG4-Related Disease
Journal of Allergy and Clinical Immunology (Elsevier) USA, Germany, 08 May 2021
Immunology
Key words: IL-1 Receptor-Antagonist (IL1-RA), IgG4-RD (IgG4-RD), Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), Multiple Sclerosis (MS), Immunoglobulin (Ig) [more]
Organism: Human
Pathological State: Multiple Sclerosis
Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway
Frontiers in Pharmacology (Frontiers Media S.A.) China, 07 May 2021
Pharmacology, Neuroscience
Key words: Ischemic Stroke, Notoginsenoside R1, Neurogenesis, Neurological Recovery, Oligodendrogenesis [more]
Organism: Rat
Tissue: Brain
Pathological State: Cerebral Ischemia
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice
Environmental Health Perspectives (National Institute of Environmental Health Sciences) Taiwan, 06 May 2021
Toxicology,Nephrology
Organism: Human
Cell Line: HK-2 cells
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration
EMBO Journal (EMBO press) UK, Australia, 05 May 2021
Regenerative Medicine
Organism: Mouse
Tissue: Small Intestine
In Situ Maturated Early-Stage Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improve Cardiac Function by Enhancing Segmental Contraction in Infarcted Rats
Journal of Personalized Medicine (MDPI) Brazil, Germany, USA, 04 May 2021
Cardiology, Stem Cell Research
Key words: Stem Cell-Therapy, Human Induced Pluripotent Stem Cells, Cardiomyocytes, Myocardial Infarction, Heart Failure, Regeneration, Cardiac Function [more]
Organism: Rat
Tissue: Heart
Pathological State: Myocardial Infarction
Effects of inverted photoperiods on the blood pressure and carotid artery of spontaneously hypertensive rats and Wistar–Kyoto rats
Journal of Hypertension (LWW Journals) China, 01 May 2021
Cardiology
Key words: Arterial Thrombosis, Atherosclerosis, Hypertension, Inverted Photoperiod [more]
Organism: Rat
Tissue: Blood Vessels
Pathological State: Atherosclerosis, Hypertension
CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation
Molecular Psychiatry (Nature) Taiwan, USA, 30 April 2021
Neuroscience
Key words: Neuroscience, Physiology [more]
Organism: Mouse
Tissue: Brain
Development of a mechanically matched Silk Scaffolded 3D clear cell renal cell carcinoma model
Materials Science and Engineering: C (Elsevier) USA, 29 April 2021
Biomaterials
Key words: Scaffold, Mechanical Testing, Tissue Engineering, Cancer Modeling [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction
Frontiers in Immunology (Frontiers Media S.A.) USA, 28 April 2021
Virology
Key words: Adeno-Associated Virus Vectors, microRNA, miR-BS, miR-142, miR-652-5p, miR-223-3p, Antigen Presenting Cells, Gene Therapy [more]
Organism: Mouse
Tissue: Muscle
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine (AAAS) USA, Canada, 28 April 2021
Oncology
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
Minoxidil-coated lysozyme-shelled microbubbes combined with ultrasound for the enhancement of hair follicle growth: Efficacy in vitro and in vivo
Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan, 27 April 2021
Pharmacology
Key words: Ultrasound, Cavitation, Lysozyme-Shelled Microbubbles, Minoxidil, Hair Follicle [more]
Organism: Mouse
Tissue: Skin
Macrophages Inhibit Ciliary Protein Levels by Secreting BMP-2 Leading to Airway Epithelial Remodeling Under Cigarette Smoke Exposure
Frontiers in Molecular Biosciences (Frontiers Media S.A.) China, 26 April 2021
Cell Biology
Key words: COPD, Cigarette Smoking, Macrophage, Bronchial Epithelial Cell, Ciliary Protein [more]
Organism: Mouse
Tissue: Lung
Cells in the gut
Atlas of the Pig Gut (Elsevier) Poland, 23 April 2021
Gastroenterology
Key words: Stem Cells, Enterocytes, Goblet Cells, Enteroendocrine Cells, M Cells, Tuft Cells, Interstitial Cells of Cajal, Myocytes
Magnetic Fluid Hyperthermia as Treatment Option for Pancreatic Cancer Cells and Pancreatic Cancer Organoids
International Journal of Nanomedicine (Dovepress) Germany, The Netherlands, 23 April 2021
Nanomedicine, Oncology
Key words: Magnetic Nanoparticles, SPION, Pancreatic Cancer, PDAC, Organoids, Magnetic Fluid Hyperthermia [more]
Organism: Human
Pathological State: Cancer
Cell Line: PaCa-2 cells, PANC-1 cells
Augmentation of the insufficient tissue bed for surgical repair of hypospadias using acellular matrix grafts: A proof of concept study
Journal of Tissue Engineering (SAGE Journals) UK, 20 April 2021
Tissue Engineering
Key words: Acellular Matrix, Biomaterial, Surgery, Hypospadias Repair, Tissue Integration [more]
Organism: Pig
Tissue: Penis
Pathological State: Hypospadias
Exposure-time-dependent subcellular staging of gold nanoparticles deposition and vesicle destruction in mice livers
Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier) China, 20 April 2021
Nanomedicine
Key words: Gold Nanoparticles, Biodistribution, Liver, Vesicle, Transmission Electron Microscopy [more]
Organism: Mouse
Tissue: Liver
Contribution of Genetic Background to the Radiation Risk for Cancer and Non-Cancer Diseases in Ptch1+/–Mice
Radiation Research (Radiation Research Society) Italy, 15 April 2021
Oncology
Persistent expression of interleukin‐17 and downstream effector cytokines in recalcitrant psoriatic lesions after ustekinumab treatment
The Journal of Dermatology (Wiley) South Korea, 15 April 2021
Dermatology
Key words: Cytokines, Interleukin‐17, Interleukin‐23, Psoriasis, Ustekinumab [more]
Organism: Human
Tissue: Skin
Pathological State: Psoriasis
Cardiac Protection by Oral Sodium Thiosulfate in a Rat Model of L-NNA-Induced Heart Disease
Frontiers in Pharmacology (Frontiers Media S.A.) The Netherlands, UK, 15 April 2021
Pharmacology
Key words: Hydrogen Sulfide, Hypertension, ACE-Inhibitor, Cardiovascular Disease, Nitric Oxide [more]
Organism: Rat
Tissue: Heart
Pathological State: Hypertension, Heart Disease
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages
Cell discovery (Nature) China, 13 April 2021
SARS-CoV-2
Key words: Innate Immunity, Mechanisms of Disease [more]
Organism: Mouse
Tissue: Lung
Pathological State: Covid-19
Enhancing Anti-Tumoral Potential of CD-NHF by Modulating PI3K/Akt Axis in U87 Ex Vivo Glioma Model
International Journal of Molecular Sciences (MDPI) Romania, 08 April 2021
Oncology
Key words: Glioblastoma, Anti-Cancer Agent, Carbon Dots, EMT, Nanomedicine [more]
Organism: Human
Cell Line: U87 cells
Next-Generation Digital Histopathology of the Tumor Microenvironment
Genes (MDPI) Austria, Australia, Romania, 07 April 2021
Medical Image Analysis
Key words: Next-Generation Digital Histopathology, Tissue Cytometry, Multiplexing, RNA ISH, Cancer, Tumor Immune Microenvironment, Tumor Microenvironment
Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer
Science Advances (AAAS) USA, 07 April 2021
Oncology
Organism: Human
Tissue: Prostate
Pathological State: Cancer
Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model
Acta Biomaterialia (Elsevier) USA, 06 April 2021
Biomaterials
Key words: 3D Printing, Hydroxyapatite, Demineralized Bone Matrix, Bone Regeneration, Spine Fusion [more]
Organism: Rat
Tissue: Spinal Cord
Therapeutic effect of modulating the NLRP3-regulated transforming growth factor-β signaling pathway on interstitial cystitis/bladder pain syndrome
Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 01 April 2021
Pharmacology
Key words: Inflammation, Bladder, Inflammasome, Curcumin, Fibrosis [more]
Organism: Mouse
Tissue: Bladder
Pathological State: Interstitial cystitis, Bladder pain syndrome
Human skin aging is associated with increased expression of the histone variant H2A. J in the epidermis
npj Aging and Mechanisms of Disease (Nature) Germany, France, 01 April 2021
Aging
Key words: Aging, Epigenetics [more]
Organism: Mouse
Tissue: Skin
Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen
Hernia (Springer) Germany, UK, 31 March 2021
Immunology, Tissue Engineering
Key words: Foreign Body Reaction, Adaptive Immune System, Innate Immune System, Mesh, Fluorescence Microscopy [more]
Organism: Human
Pathological State: Abdominal wall hernia
Single-cell sequencing reveals the transcriptome and TCR characteristics of pTregs and in vitro expanded iTregs
Frontiers in Immunology (Frontiers Media S.A.) China, 31 March 2021
Immunology
Key words: Single-Cell Sequencing, In Vitro, Regulatory T Cells, Colorectal Cancer, Chemokine Receptors [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
n-Butyl Benzyl Phthalate Exposure Promotes Lesion Survival in a Murine Endometriosis Model
International Journal of Environmental Research and Public Health (MDPI) Taiwan, 31 March 2021
Reproductive Medicine
Key words: N-Butyl Benzyl Phthalate, CD44, Dendritic Cell, Endometriosis [more]
Organism: Mouse
Tissue: Endometrium
Pathological State: Endometriosis
Therapeutic Effect of Cinnamomum osmophloeum Leaf Extract on Oral Mucositis Model Rats Induced by 5-Fluororacil via Influencing IL-1β and IL-6 Levels
Processes (MDPI) Indonesia, Taiwan, 31 March 2021
Pharmacology
Key words: Cinnamomum Osmophloeum, Oral Mucositis, Model Rat, 5-Fluororacil, IL-1β, IL-6 [more]
Organism: Rat
Tissue: Mucosa
Pathological State: Oral Mucositis
Hypoxia and oxidative stress induce sterile placental inflammation in vitro
Scientific Reports (Nature) UK, Canada, 31 March 2021
Reproductive Medicine
Key words: Developmental Biology, Diseases, Immunology, Medical Research, Pathogenesis [more]
Organism: Mouse
Tissue: Placenta
Pathological State: Placental inflammation
Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells
Immunity (Cell Press) Germany, 30 March 2021
Immunology
Organism: Human
Tissue: Skin
Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia
Hypertension (American Heart Association) Austria, Germany, Norway, UK, 29 March 2021
Reproductive Medicine
Key words: Candesartan, Leptin, Oxygen, Respiration, Trophoblasts [more]
Organism: Human
Tissue: Placenta
Expression of CD9 on porcine lymphocytes and its relation to T cell differentiation and cytokine production
Developmental & Comparative Immunology (Elsevier) Austria, France, 27 March 2021
Immunology
Key words: Tetraspanin, CD9, Porcine, Lymphocyte, Memory [more]
Organism: Mouse
Tissue: Lymphoid Tissue
Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia
JCI Insight (The American Society for Clinical Investigation) USA, 22 March 2021
Aging
Key words: Aging, T Cells [more]
Organism: Mouse
Tissue: Lung
Pathological State: Influenza Infection, Pneumonia
Selective Denervation of the Facial Dermato-Muscular Complex in the Rat: Experimental Model and Anatomical Basis
Frontiers in Neuroanatomy (Frontiers Media S.A.) Austria, Switzerland, 22 March 2021
Neuroscience
Key words: Facial Nerve, Trigeminal Nerve, Motor-Sensory Control, Facial Muscles, Axon Quantification, Whole-Mount Staining [more]
Organism: Rat
Tissue: Nerve
Inhibition of vascular adhesion protein‐1 enhances the anti‐tumor effects of immune checkpoint inhibitors
Cancer Science (Japanese Cancer Association) Japan, Bangladesh, 18 March 2021
Oncology
Key words: CTLs, H2O2, ICIs, Immunosuppression, VAP‐1 Inhibitor [more]
Organism: Mouse
Tissue: Colon
Pathological State: Cancer
Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis
Cell Death & Differentiation (Nature) China, USA, 17 March 2021
Oncology
Key words: Cancer Metabolism, Phospholipids [more]
Organism: Human
Tissue: Kidney
Pathological State: Cancer
Luteolin Modulates the NF-E2-Related Factor 2/Glutamate–Cysteine Ligase Pathway in Rats with Spinal Cord Injury
Journal of Medicinal Food (Mary Ann Liebert Inc.) China, 16 March 2021
Neuroscience
Key words: Luteolin, Nrf2/GCL Pathway, Oxidative Stress, Spinal Cord Injury [more]
Organism: Rat
Tissue: Spinal Cord
Pathological State: Spinal Cord Injury
Machine perfused donor kidneys as a source of human renal endothelial cells
American Journal of Physiology (APS Journals) The Netherlands, 15 March 2021
Nephrology
Key words: Kidney, Transplantation, Endothelial Cells, Machine Perfusion, Perfusate [more]
Organism: Human
Pathological State: Organ Transplantation
Cell Line: MP-PRECs
Genetic Drivers of Head and Neck Squamous Cell Carcinoma: Aberrant Splicing Events, Mutational Burden, HPV Infection and Future Targets
Genes (MDPI) South Africa, Greece, 15 March 2021
Oncology
Key words: Head and Neck Squamous Cell Carcinoma (HNSCC), Aberrant Splicing Events, Human Papillomavirus (HPV) Infection, Non-Coding RNA (ncRNA), Methylation, Mutational Burden [more]
Pathological State: Cancer, HPV Infection
A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice
Antioxidants (MDPI) Taiwan, USA, 13 March 2021
Cardiology, Endocrinology
Key words: Diabetic Cardiomyopathy, 4-Hydroxy-2-Nonenal, Mitochondrial Aldehyde Dehydrogenase 2, AD-9308 [more]
Organism: Mouse
Tissue: Heart
Pathological State: Diabetes
MicroRNA-126 inhibits pathological retinal neovascularization via suppressing vascular endothelial growth factor expression in a rat model of retinopathy of prematurity
European Journal of Pharmacology (Elsevier) Taiwan, 13 March 2021
Pharmacology
Key words: miR-126, Retinal Pigment Epithelium Cells, Vascular Endothelial Growth Factor, Oxygen-Induced Retinopathy, Neovascularization, Rat [more]
Organism: Rat
Tissue: Eye
Pathological State: Retinopathy
N-Acetyl Cysteine Overdose Inducing Hepatic Steatosis and Systemic Inflammation in Both Propacetamol-Induced Hepatotoxic and Normal Mice
Antioxidants (MDPI) Taiwan, 12 March 2021
Hepathology
Key words: Acetaminophen Overdose, N-Acetyl Cysteine Overdose, Two Inbred Mouse Strains, Hepatic Inflammation, Systemic Inflammation, Microvesicular Steatosis [more]
Organism: Mouse
Tissue: Liver
Pathological State: Hepatic Steatosis, Systemic Inflammation
Dissecting pathways to thrombocytopenia in a mouse model of visceral leishmaniasis
Blood Advances (ASH Publications) UK, 12 March 2021
Immunology
Key words: Blood Platelets, Infections, Leishmania Donovani, Leishmaniasis, Visceral, Mice, Thrombocytopenia, Drug Clearance, Thrombopoietin, Spleen, Liver [more]
Organism: Mouse
Tissue: Liver
Pathological State: Leishmaniasis
CHPF Regulates the Aggressive Phenotypes of Hepatocellular Carcinoma Cells via the Modulation of the Decorin and TGF-β Pathways
Cancers (MDPI) Taiwan, 12 March 2021
Oncology
Key words: Hepatocellular Carcinoma, Tumor Microenvironment, Chondroitin Polymerizing Factor, Chondroitin Sulfate, Decorin [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma
Cells (MDPI) Austria, 12 March 2021
Oncology
Key words: TissueFaxs, TWIST, ZEB, SCC-25, FaDu, UPCI-SCC090 [more]
Organism: Human
Tissue: Mucosa
Pathological State: Cancer
Dietary Modification Alters the Intrarenal Immunologic Micromilieu and Susceptibility to Ischemic Acute Kidney Injury
Frontiers in Immunology (Frontiers Media S.A.) South Korea, 11 March 2021
Immunology, Nephrology
Key words: Diet, High-Salt Diet, High-Fat Diet, Acute Kidney Injury, Immunologic Micromilieu, Ischemia-Reperfusion Injury [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Acute Kidney Injury
Genome-wide 5-hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer
Genomics, Proteomics & Bioinformatics (Elsevier) China, 11 March 2021
Proteomics, Oncology
Key words: 5-Hydroxymethylcytosine (5hmC), Breast Cancer, Lymph Node Metastasis, MAP7D1, Biomarker [more]
Organism: Human
Tissue: Breast, Lymphoid Tissue
Pathological State: Cancer
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma
Science Translational Medicine (AAAS) USA, 10 March 2021
Oncology
Organism: Human
Tissue: Brain
Pathological State: Cancer
Aurka loss in CD19+ B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production
Theranostics (Ivyspring International Publisher) China, Japan, 04 March 2021
Cell Biology
Key words: Aurora-A, Thrombopoietin, STAT3, IL-6, Megakaryocytopoiesis. [more]
Organism: Mouse
Tissue: Spleen
CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment
American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, 01 March 2021
Oncology
Key words: Breast Cancer, Chondroitin Sulfate, CHPF, Tumor Microenvironment, Syndecan-4 [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury
Biomedicine & Pharmacotherapy (Elsevier) China, USA, 27 February 2021
Gastroenterology
Organism: Mouse
Tissue: Small Intestine
Parathyroid hormone induces transition of myofibroblasts in arteriovenous fistula and increases maturation failure
Endocrinology (Oxford Academic) Taiwan, USA, 26 February 2021
Endocrinology
Key words: Arteriovenous Fistula (AVF), Fibrosis, Hemodialysis, Parathyroid Hormone (PTH) [more]
Organism: Mouse
Tissue: Peritoneum, Muscle
Gastric Enzyme Supplementation Inhibits Food Allergy in a BALB/c Mouse Model
Nutrients (MDPI) Austria, 26 February 2021
Allergy Research
Key words: Food Allergy, Gastric Enzymes, Gastric Acid Suppression, Systemic Allergic Response, Allergy Prevention [more]
Organism: Mouse
Tissue: Stomach
Genetic Background Effects on the Expression of an Odorant Receptor Gene
Frontiers in Cellular Neuroscience (Frontiers Media S.A.) Brazil, 25 February 2021
Neuroscience
Key words: DNA Methylation, Odorant Receptor Gene, Olfactory Receptor Gene, Genetic Background, Gene Expression, Single Nucleotide Polymorphism [more]
Organism: Mouse
Tissue: Mucosa
Regulation of pancreatic fibrosis by acinar cell-derived exosomal miR-130a-3p via targeting of stellate cell PPAR-γ
Journal of Inflammation Research (Dovepress) China, 24 February 2021
Gastroenterology
Key words: Pancreatitis, Exosomes, miR-130a-3p, Pancreatic Fibrosis, PPAR- γ [more]
Organism: Rat
Tissue: Pancreas
Pathological State: Pancreatitis
Pollen grain microscopic image classification using an ensemble of fine-tuned deep convolutional neural networks
International Conference on Pattern Recognition (Springer) Austria, UK, 21 February 2021
Machine Learning
Key words: Medical Image Analysis
Accuracy of HPV E6/E7 mRNA examination using in situ hybridization in diagnosing cervical intraepithelial lesions
Diagnostic Pathology (Springer) China, 19 February 2021
Pathology
Key words: Cervical Intraepithelial Neoplasia, CIN, Diagnostic Accuracy, E6/E7 mRNA, In Situ Hybridization [more]
Organism: Human
Tissue: Cervix
Pathological State: Cervical lesions
T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells
Scientific Reports (Nature) USA, South Africa, UK, Germany, 16 February 2021
Virology
Key words: HIV Infections, Monocytes and Macrophages, Mucosal Immunology, Retrovirus, Virology, Virus–Host Interactions [more]
Organism: Human
Tissue: Lung
Pathological State: HIV infection
Imbalance of TGF-β1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness
Molecular Therapy (Elsevier) China, 15 February 2021
Oncology
Organism: Human
Tissue: Liver
Pathological State: Cancer
Curcumin inhibits the growth of liver cancer by impairing myeloid‑derived suppressor cells in murine tumor tissues
Oncology Letters (Spandidos Publications) China, 12 February 2021
Oncology
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4
Cancer Communications (Wiley) China, 11 February 2021
Oncology
Key words: Gastric Cancer, Glucose Transporter 4, Glycolysis, Insulin Gene Enhancer Protein 1, Tumorigenesis [more]
Organism: Human
Tissue: Stomach
Pathological State: Cancer
Global Analysis of Lysine Acetylome Reveals the potential role of CCL18 in non‐small cell lung cancer
Proteomics (Wiley) China, 11 February 2021
Proteomics
Key words: Acetylome, CCL18, Non-Small Cell Lung Cancer [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice
Journal of Affective Disorders (Elsevier) China, 10 February 2021
Neuroscience
Key words: Chronic stress stimulated depression model, Hippocampus, Hydrogen sulfide, Inflammatory, Aerobic exercise [more]
Organism: Mouse
Tissue: Brain
Pathological State: Depression
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms
Translational Research (Elsevier) Austria, UK, Sweden, 09 February 2021
Cardiology
Organism: Human
Tissue: Blood Vessels
Pathological State: Abdominal aortic aneurysms
IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer
OncoImmunology (Taylor & Francis) Austria, Italy, UK, 08 February 2021
Oncology
Key words: IgG4, IgE, Tumor-Associated Macrophages, M2b, Allergooncology [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Anti-inflammatory effects of Radix aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice
Journal of Ethnopharmacology (Elsevier) Taiwan, 07 February 2021
Pharmacology
Key words: 5-Fluorouracil (5-FU), Radix Aucklandiae, Intestinal Mucositis, Goblet Cell, Anti-Inflammatory [more]
Organism: Mouse
Tissue: Small Intestine
Pathological State: Intestinal Mucositis
Hiltonol Cocktail Kills Lung Cancer Cells by Activating Cancer-Suppressors, PKR/OAS, and Restraining the Tumor Microenvironment
International Journal of Molecular Sciences (MDPI) Taiwan, USA, Singapore, 05 February 2021
Oncology
Key words: NSCLC (Non-Small Cell Lung Cancer), Combinatorial Treatment with Hiltonol+++ Cocktail [Hiltonol+Anti-IL6+Stattic+AG490], Tumorigenic Microenvironment, Anti- and Pro-Tumorigenic Cytokine Production, Tumor-Suppressors PKR (Protein Kinase R) And OAS (2′5′ Oligoadenylate Synthetase) [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Morphine acts on spinal dynorphin neurons to cause itch through disinhibition
Science Translational Medicine (AAAS) USA, UK, 03 February 2021
Neuroscience
Organism: Mouse
Tissue: Skin
Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF
Oncology Reports (Spandidos Publications) Austria, 02 February 2021
Oncology
Organism: Human
Cell Line: Melanoma cells
Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer
OncoImmunology (Taylor & Francis) USA, 02 February 2021
Oncology
Key words: Irreversible Electroporation, Dendritic Cell Vaccine, Pancreatic Ductal Adenocarcinoma, Magnetic Resonance Imaging [more]
Organism: Mouse
Tissue: Pancreas
Pathological State: Cancer
iTRAQ-based Quantitative Proteomic Analysis of Dural Tissues Reveals Upregulated Haptoglobin to be a Potential Biomarker of Moyamoya Disease
Current Proteomics (ingentaconnect) China, 01 February 2021
Proteomics
Key words: Moyamoya Disease, Dura Mater, Proteomics, iTRAQ, Haptoglobin, Strokes
Nerve Fibers in the Tumor Microenvironment Are Co-Localized with Lymphoid Aggregates in Pancreatic Cancer
Journal of Clinical Medicine (MDPI) Germany, The Netherlands, UK, Austria, 30 January 2021
Oncology
Key words: Tumor Microenvironment, Machine Learning, Nerve Fiber Density, Spatial Arrangements, Tertiary Lymphoid Structures, Pancreatic Cancer [more]
Organism: Mouse
Tissue: Pancreas
Pathological State: Cancer
Endothelial-Derived miR-17∼ 92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury
Journal of The American Society of Nephrology (Am Soc Nephrol) USA, 29 January 2021
Nephrology
Key words: microRNA, Acute Kidney Injury, Renal Microvasculature [more]
Pathological State: Acute Kidney Injury
Mer tyrosine kinase (MerTK) as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease
Rheumatology (Oxford Academic) Italy, USA, Japan, 29 January 2021
Rheumatology
Key words: IgG4-Related Disease, Macrophages, MerTK, Protein S, Fibrosis [more]
Organism: Human
Tissue: Submandibular Gland, Pancreas
Pathological State: IgG4-Related Disease
Effects of Nicorandil on Inflammation, Apoptosis and Atherosclerotic Plaque Progression
Biomedicines (MDPI) Austria, 27 January 2021
Cardiology
Key words: Nicorandil, Inflammation, Apoptosis, Atherosclerosis, Plaque, Plaque Stabilization [more]
Organism: Mouse
Tissue: Blood Vessels
Pathological State: Atherosclerosis
Interleukin-24 protects against liver injury in mouse models
EBioMedicine (THE LANCET) Taiwan, 25 January 2021
Hepathology
Key words: Interleukin-24, Liver Fibrosis, Thioacetamide-Induced Liver Injury, Hepatic Stellate Cells [more]
Organism: Human
Tissue: Liver
Pathological State: Liver Fibrosis
Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model
Gastroenterology Research and Practice (Hindawi Publishing Corporation) Taiwan, 25 January 2021
Gastroenterology
Organism: Mouse
Tissue: Small Intestine
Pathological State: Intestinal Mucositis
A Hepatitis B Virus-Derived Peptide Exerts an Anticancer Effect via TNF/iNOS-producing Dendritic Cells in Tumor-Bearing Mouse Model
Cancers (MDPI) South Korea, 22 January 2021
Oncology
Key words: HBV-Derived Poly6 Peptide, TNF/ iNOS-Producing DCs (Tip-DCs), Type 1 Interferon (IFN-I), CD40, Cancer Immunotherapy [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Androgen Plays a Carcinogenic Role in EOC via the PI3K/AKT Signaling Pathway in an AR-Dependent Manner
Journal of Cancer (Ivyspring International Publisher) China, 21 January 2021
Oncology
Key words: Ovarian Carcinoma, Androgen Receptor (AR), Tissue Microarray (TMA), Proliferation Promotion, PI3K/AKT Signalling Pathway [more]
Organism: Human
Tissue: Ovaries
Pathological State: Cancer
Performance and Meat Quality of Intrauterine Growth Restricted Pigs
Animals (MDPI) Poland, 20 January 2021
Zoology
Key words: IUGR, Pigs, Growth Performance, Meat Quality, Sensory Evaluation [more]
Organism: Pig
Tissue: Muscle
Pathological Pulmonary Vascular Remodeling is Induced by Type V Collagen in a Model of Scleroderma
Pathology-Research and Practice (Elsevier) Brazil, USA, 19 January 2021
Cardiology
Key words: Animal Model, Scleroderma, Collagen V, Vascular Disease, Endothelium [more]
Organism: Rabbit
Tissue: Lung
Pathological State: Scleroderma, Vascular Disease
Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections
Scientific Reports (Nature) USA, The Netherlands, 15 January 2021
Bioimaging
Key words: Biofilms, Infectious Diseases [more]
Pathological State: Staphylococcus aureus Infection
PEG-GO@ XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition
European Journal of Pharmacology (Elsevier) China, USA, 14 January 2021
Oncology, Nanomedicine
Key words: Graphene Oxide, Xanthohumol, Breast Cancer Metastasis, Mitochondria, Epithelial-Mesenchymal Transition, Energy Metabolism [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Macromolecular crowding as a tool to screen anti-fibrotic drugs: the Scar-in-a-Jar system revisited
Frontiers in Medicine (Frontiers Media S.A.) The Netherlands, China, USA, Switzerland, 14 January 2021
Biological Methods
Key words: Macromolecular Crowding, Drug Testing, Fibrosis, Collagen, Myofibroblast [more]
Organism: Human
Cell Line: adult primary human dermal fibroblasts
Mesenchymal stem cell‐glioblastoma interactions mediated via kinin receptors unveiled by cytometry
Cytometry Part A (Wiley) Brazil, 13 January 2021
Medical Image Analysis
Key words: Cytometry, Glioblastoma, Kinin Receptors, Kinin‐B1 Receptor, Kinin‐B2 Receptor, Mesenchymal Stem Cells [more]
Organism: Human
Cell Line: Glioblastoma (U87) cells, Mesenchymal stem cell
Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition
Nature Communications (Nature) China, 12 January 2021
Neuroscience
Key words: Molecular Neuroscience, Schizophrenia [more]
Organism: Mouse
Tissue: Brain
Stem Cell-Derived Respiratory Epithelial Cell Cultures as Human Disease Models
American Journal of Respiratory Cell and Molecular Biology (Wiley) UK, 11 January 2021
Stem Cell Research
Key words: Respiratory Epithelium, Epithelial Cells, Cell Culture, Cloning, Stem Cells
Overexpression of GLUT3 promotes metastasis of triple‐negative breast cancer by modulating the inflammatory tumor microenvironment
Journal of Cellular Physiology (Wiley) Taiwan, 09 January 2021
Oncology
Key words: Glycolysis, Inflammation, Triple‐Negative Breast Cancer, Tumor Microenvironment, Tumor‐Associated Macrophage [more]
Organism: Mouse
Tissue: Lung
Pathological State: Cancer
Development and Validation of Sorafenib-eluting Microspheres to Enhance Therapeutic Efficacy of Transcatheter Arterial Chemoembolization in a Rat Model of of Hepatocellular Carcinoma
Radiology: Imaging Cancer (Royal Society of Chemistry) USA, 08 January 2021
Oncology
Organism: Rat
Tissue: Liver
Pathological State: Cancer
Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade
Science Immunology (Science) Austria, 08 January 2021
Immunology, Dermatology
Organism: Human
Tissue: Skin
Pathological State: Dermatitis
Differential expression of microRNA miR-150-5p in IgA nephropathy as a potential mediator and marker of disease progression.
Kidney International (Elsevier) UK, Canada, Germany, Spain, 06 January 2021
Nephrology
Key words: IgA Nephropathy, microRNA [more]
Organism: Human
Tissue: Kidney
Pathological State: IgA nephropathy
Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1
Cancer Research (AACR Publications) China, USA, 05 January 2021
Oncology
Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation
The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, 04 January 2021
Immunology
Organism: Mouse
Tissue: Liver
IN VITRO CHARACTERIZATION OF HYDROXYAPATITE-BASED BIOMATERIALS, USING MESENCHYMAL STEM CELL CULTURES FROM HUMAN BONE …
Journal of Science and Arts (Josa.ro) Romania, 30 December 2020
Biomaterials
Key words: Hydroxyapatite, Calcium Fructoborate, Mesenchymal Stem Cell, Human Bone Marrow [more]
Organism: Human
Cell Line: Mesenchymal stem cells
Persistent inhibition of Candida albicans biofilm and hyphae growth on titanium by graphene nanocoating
Dental Materials (Elsevier) Singapore, USA, UK, 25 December 2020
Biomaterials
Key words: Implant, Surface Free Energy, Contact Angle, Topography, Microbial Attachment, Antiadhesive Coating, Peri-Implantitis [more]
Organism: C. albicans
Obesity is associated with shorter telomere length in prostate stromal cells in men with aggressive prostate cancer
Cancer Prevention Research (AACR Publications) USA, 22 December 2020
Oncology
PD‐L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer
Cancer Science (Wiley) Australia, 20 December 2020
Oncology
Key words: CD8, Colon Cancer, Dendritic Cells, PD‐L1, T Cells
Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma
International Journal of Molecular Sciences (MDPI) Japan, USA, 19 December 2020
Oncology
Key words: Anaplastic Lymphoma Kinase (ALK), B Cell, Heterogeneity, Immune Checkpoint, Large Cell Neuroendocrine Carcinoma (LCNEC), Neuroendocrine Tumors (NET), Regulatory T-Cells (Tregs), Programmed Death-Ligand 1 (PD-L1), Tumor-Infiltrating Lymphocyte (TIL), Tumor-Immune Microenvironments (TIME) [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
Parp1-Dependent DNA Double-Strand Break Repair in Irradiated Late Pachytene Spermatocytes
DNA and Cell Biology (Mary Ann Liebert Inc.) Saudi Arabia, Egypt, Germany, 18 December 2020
Reproductive Medicine
Key words: Alternative NHEJ, DNA Repair, First Meiotic Prophase, γ-H2AX, Homologous Recombination, Parp1, Spermatogenesis [more]
Organism: Human
Cell Line: Spermatocytes
Differential mast cell phenotypes in benign versus cancer tissues and prostate cancer oncologic outcomes
The Journal of Pathology (Wiley) USA, 18 December 2020
Oncology
Key words: Prostate Cancer, Mast Cells, Metastases, CXCR4, TFE3, KIT, Microenvironment [more]
Organism: Human
Tissue: Prostate
Pathological State: Cancer
ZFHX3 Knockdown Dysregulates Mitochondrial Adaptations to Tachypacing in Atrial Myocytes through Enhanced Oxidative Stress and Calcium Overload
Acta Physiologica (Wiley) Taiwan, Japan, 17 December 2020
Physiology
Key words: Atrial Fibrillation, Calcium, Mitochondria, Tachypacing, ZFHX3 [more]
Organism: Human
Cell Line: HL‐1 cells
CD4+ CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum
The Journal of Immunology (American Association of Immunologists) Canada, Saudi Arabia, Japan, USA, 16 December 2020
Immunology
Organism: Human
Tissue: Mediastinum
Pathological State: Mediastinitis
Tribbles Pseudokinase 3 Contributes to Cancer Stemness of Endometrial Cancer Cells by Regulating β-Catenin Expression
Cancers (MDPI) Taiwan, 15 December 2020
Oncology
Key words: Tribbles Pseudokinase 3, Endometrial Cancer, Cancer Stem Cells, β-Catenin, Epithelial–Mesenchymal Transition [more]
Organism: Human
Cell Line: Endometrial Cancer Cell Lines (AN3CA and HEC1A)
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals
Cell Systems (Cell Press) USA, Japan, 15 December 2020
Neuroscience
Key words: Alzheimer's Diseasea, Myloid Beta, Synaptic Dysfunction, Presynapse, Synaptic Vesicles, Proteostasis, Mass Spectrometry, Proteomics, APP Knockin Mice [more]
Organism: Mouse
Tissue: Brain
Pathological State: Alzheimer's Disease
Multicohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors
Clinical Colorectal Cancer (Elsevier) USA, Japan, Australia, 10 December 2020
Oncology
Organism: Human
Tissue: Stomach
Pathological State: Cancer
Spatiotemporal Up-Regulation of Mu Opioid Receptor 1 in Striatum of Mouse Model of Huntington's Disease Differentially Affecting Caudal and Striosomal Regions
Frontiers in Neuroanatomy (Frontiers Media S.A.) USA, Japan, 10 December 2020
Neuroscience
Key words: Mu Opioid Receptors, Huntington's Disease, Neostriatum, Movement Disorders, Mood Disorders, Animal Models of Human Disorders, Striosome [more]
Organism: Mouse
Tissue: Brain
Pathological State: Huntington's Disease
Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro
Nanomaterials (MDPI) Romania, 09 December 2020
Nanomedicine
Key words: Zirconia, Mesenchymal Stem Cells, Micro-Nano Topography, Osteogenic Differentiation, Bone-Anchored Hearing Aid (BAHA) [more]
Organism: Human
Cell Line: hMSCs
The effect of dietary supplementation with high-or low-dose omega-3 fatty acid on inflammatory pathology after traumatic brain injury in rats
Translational Neuroscience (degruyter) USA, 09 December 2020
Neuroscience
Key words: Dietary Supplementation, Docosahexanoic Acid, Eicosapentaenoic Acid, Neuroinflammation, Neuroprotection, Omega-3 Fatty Acid, Traumatic Brain Injury [more]
Organism: Rat
Tissue: Brain
Pathological State: Traumatic Brain Injury
Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis
Cell Death & Disease (Nature) China, 07 December 2020
Oncology
Key words: Bladder Cancer, Long Non-Coding RNAs, Oncogenesis [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients
Translational Oncology (Elsevier) China, 06 December 2020
Oncology
Key words: Liver Cancer, Single-Cell Transcriptome, Cancer-Distinct Fibroblast, SPARCL1 [more]
Organism: Human
Tissue: Liver
Pathological State: Cancer
Lactic acidosis interferes with toxicity of perifosine to colorectal cancer spheroids: multimodal imaging analysis
Frontiers in Oncology (Frontiers Media S.A.) Czech Republic, Switzerland, China, 04 December 2020
Oncology
Key words: Perifosine, Akt Kinase, Tumor Environment, Lactic Acidosis, Alkalization, Signal Co-Registration, Mass Spectrometry Imaging, Colorectal Cancer [more]
Organism: Human
Cell Line: HT-29 and HCT-116 cells
AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study
Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) Czech Republic, France, Poland, Germany, 03 December 2020
Cardiology
Key words: Pulsed Field Ablation, Irreversible Electroporation (IRE), Radiofrequency Ablation, Atrial Fibrillation, Ventricular Arrhythmia (VA), Preclinical Cardiology [more]
Organism: Pig
Tissue: Heart
Shear stress-exposed pulmonary artery endothelial cells fail to upregulate HSP70 in chronic thromboembolic pulmonary hypertension
PLoS One (PLOS) Brazil, 03 December 2020
Cardiology
Key words: Shear Stresses, Endothelial Cells, Heat Shock Response, Pulmonary Arteries, Peas, Flow Cytometry, Nitric Oxide, Pulmonary Hypertension [more]
Organism: Human
Pathological State: Pulmonary hypertension
Cell Line: HPAECs
Infiltration of metastatic lymph nodes with PD-1+ T cells is associated with improved disease-free and overall survival in resected N+ NSCLC
American Journal of Cancer Research (e-Century Publishing Corporation) China, USA, 01 December 2020
Oncology
Key words: NSCLC, Metastatic Lymph Node, T Cell Subsets, PD-1, TIM-3 [more]
Organism: Human
Tissue: Lung
Pathological State: Cancer
The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients
Cancer Letters (Elsevier) Germany, 01 December 2020
Oncology
Key words: OSCC, Diabetes Mellitus, TIL, Metabolism, Prognosis [more]
Organism: Human
Pathological State: Cancer
p21‐activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1
Molecular Carcinogenesis (Wiley) China, 01 December 2020
Oncology
Key words: Cell Proliferation, Esophageal Squamous Cell Carcinoma, LASP1, Metastasis, PAK4 [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Cross-Reactive Effects of Vaccines: Heterologous Immunity between Tetanus and Chlamydia
Vaccines (MDPI) Serbia, Austria, 01 December 2020
Immunology
Key words: Vaccination, Heterologous Immunity, Antibodies, Tetanus, Chlamydia, Cross-Reactivity [more]
Organism: Human
Cell Line: Human conjunctival epithelial cell line
Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats
Frontiers in Neuroscience (Frontiers Media S.A.) China, 30 November 2020
Neuroscience
Key words: Levodopa, Hippocampus, Global Cerebral Ischemia Reperfusion Injury, Structural Synaptic Plasticity, Cognitive Function [more]
Organism: Rat
Tissue: Brain
Pathological State: Cerebral Ischemia
Characterization of epithelial cells, connective tissue cells and immune cells in human upper airway mucosa by immunofluorescence multichannel image cytometry: a pilot study
Histochemistry and Cell Biology (Springer) Austria, 29 November 2020
Medical Image Analysis
Key words: Image Cytometry, Fluorescent Antibody Technique, Immunohistochemistry, Nasal Mucosa, Sinusitis [more]
Organism: Human
Tissue: Mucosa
Pathological State: Chronic Rhinosinusitis
MicroRNA-146a suppresses tumor malignancy via targeting vimentin in esophageal squamous cell carcinoma cells with lower fibronectin membrane assembly
Journal of Biomedical Science (BMC) Taiwan, 28 November 2020
Oncology
Key words: ESCC, MiR-146a, Vimentin, Cell Migration, Invasion [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Lactobacillus Attenuate the Progression of Pancreatic Cancer Promoted by Porphyromonas Gingivalis in K-rasG12D Transgenic Mice
Cancers (MDPI) Taiwan, 26 November 2020
Oncology
Key words: Caerulein, Lactobacillus, Pancreatic Ductal Adenocarcinoma, Porphyromonas Gingivalis, Transforming Growth Factor-β [more]
Organism: Human
Tissue: Pancreas
Pathological State: Cancer
Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages
Cancers (MDPI) Taiwan, UK, 26 November 2020
Oncology
Key words: Visfatin, Breast Cancer, Tumor-Associated Macrophages, CXCL1 [more]
Organism: Human
Tissue: Breast
Pathological State: Cancer
Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice
Free Radical Biology and Medicine (Elsevier) China, 26 November 2020
Neuroscience
Key words: Nrf2, Motor Dysfunction, Brain Iron Metabolism, Oxidative Stress, FPN1 [more]
Organism: Mouse
Tissue: Brain
Neuropathology changed by 3-and 6-months low-level PM 2.5 inhalation exposure in spontaneously hypertensive rats
Particle and Fibre Toxicology (Springer) Taiwan, 26 November 2020
Neuroscience
Key words: Air Pollution, Autophagy, Central Nervous System Toxicity, Particulate Matter, Tau [more]
Organism: Rat
Tissue: Brain
Electric Pulse Responsive Magnetic Nanoclusters Loaded with Indoleamine 2, 3-Dioxygenase Inhibitor for Synergistic Immuno-Ablation Cancer Therapy
ACS Applied Materials & Interfaces (ACS Publications) USA, 25 November 2020
Oncology
Key words: Local Ablation, Irreversible Electroporation, Indoleamine 2, 3-Dioxygenase Inhibitor, Magnetic Nanoparticles, Immunotherapy [more]
Organism: Mouse
Tissue: Xenograft Tumor
Pathological State: Cancer
Development of Rift valley fever encephalitis in rats is mediated by early infection of olfactory epithelium and neuroinvasion across the cribriform plate
Journal of General Virology (Microbiology Society) USA, 24 November 2020
Virology
Key words: Aerosol, Cribriform Plate, Encephalitis, Olfactory Bulb, Pathogenesis, Rift Valley Fever Virus [more]
Organism: Rat
Tissue: Mucosa
Pathological State: Encephalitis
Time-resolved analysis of Staphylococcus aureus invading the endothelial barrier
Virulence (Taylor & Francis) The Netherlands, 22 November 2020
Microbiology
Key words: Staphylococcus Aureus, MRSA, Endothelium, Invasion, Intracellular [more]
Organism: Human
Cell Line: HUVECs
Type II natural killer T cells contribute to protection against systemic methicillin-resistant Staphylococcus aureus infection
Frontiers in Immunology (Frontiers Media S.A.) USA, 18 November 2020
Immunology
Key words: Staphylococcus Aureus, Natural Killer T Cells, CD1, Lipid Antigens, Cytokine, Knockout Mice [more]
Organism: Mouse
Tissue: Kidney
Pathological State: Staphylococcus aureus Infection
Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease
Science Translational Medicine (AAAS) Austria, 18 November 2020
Dermatology
Organism: Human
Tissue: Skin
Pathological State: Graft-versus-host disease
Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
The Journal of Infectious Diseases (Oxford Academic) China, 17 November 2020
SARS-CoV-2
Key words: IL-37, SARS-CoV-2, COVID-19, Inflammation, Clinical Outcomes [more]
Organism: Mouse
Tissue: Lung
Pathological State: COVID-19
Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model
Scientific Reports (Nature) Germany, Ireland, 16 November 2020
Neuroscience
Key words: Biological Techniques, Molecular Biology, Neuroscience [more]
Organism: Mouse
Tissue: Brain
HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age‐dependent changes
Journal of Neuroscience Research (Wiley) Austria, 12 November 2020
Neuroscience
Key words: Auditory Development, Auditory Neuron Diversity, Axon Initial Segment, HCN Channels, Prestin, RRID:AB_90725, RRID:AB_2039906, RRID:AB_2302038, RRID:AB_2313584, RRID:AB_2313726, RRID:AB_2336419, RRID:AB_2336420, RRID:AB_2336790, RRID:AB_2340477, RRID:AB_2340452, RRID:AB_2340593, RRID:AB_2341028, RRID:AB_2617143, RRID:AB_2756625, RRID:AB_2756742, RRID:SCR_002865, RRID:SCR_013652, RRID:SCR_014823, Sound Coding, Spiral Ganglion Neurons, Voltage Gated [more]
Organism: Mouse, Human
Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
Nature Communications (Nature) Japan, USA, 09 November 2020
Hepathology
Key words: Molecular Drug Discovery, Liver Diseases, Molecular Medicine [more]
Organism: Mouse
Tissue: Bone Marrow
Pathological State: Liver Injury
CO2-Responsive Water-Soluble Conjugated Polymers for In Vitro and In Vivo Biological Imaging
Biomacromolecules (ACS Publications) Taiwan, 06 November 2020
Bioimaging
Organism: Zebrafish
Tissue: Whole Organism
Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19
Cell Research (Nature) China, 06 November 2020
Immunology, SARS-CoV-2
Key words: Immunology, Innate Immunity [more]
Organism: Mouse
Tissue: Lung
Pathological State: Covid-19
Evidence for a non-stochastic two-field hypothesis for persistent skin cancer risk
Scientific Reports (Nature) USA, 05 November 2020
Oncology
Key words: Cancer Microenvironment, Cancer Models, Skin Cancer, Squamous Cell Carcinoma [more]
Organism: Mouse
Tissue: Skin
Pathological State: Cancer
Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14
Metallomics (Royal Society of Chemistry) Austria, 04 November 2020
Reproductive Medicine
Organism: Human
Tissue: Placenta
Metformin chlorination byproducts in drinking water exhibit marked toxicities of a potential health concern
Environment International (Elsevier) China, 03 November 2020
Toxicology
Key words: Metformin, Metformin Chlorination Byproduct, Drinking Water, Toxicity, Public Health [more]
Organism: Mouse
Tissue: Small Intestine
Effect of route of administration on the efficacy of dendritic cell vaccine in PDAC mice
American Journal of Cancer Research (e-Century Publishing Corporation) USA, 01 November 2020
Oncology
Key words: Pancreatic Cancer, Dendritic Cell, Route of Administration [more]
Organism: Mouse
Tissue: Pancreas
Pathological State: Cancer
Therapeutic Efficacy of GC1118, a Novel Anti-EGFR Antibody, against Glioblastoma with High EGFR Amplification in Patient-Derived Xenografts
Cancers (MDPI) South Korea, 31 October 2020
Oncology
Key words: Glioblastoma, Epidermal Growth Factor Receptor, Monoclonal, Xenograft, Amplification [more]
Organism: Mouse
Tissue: Brain
Pathological State: Cancer
P2Y2 receptor activation promotes esophageal cancer cells proliferation via ERK1/2 pathway
European Journal of Pharmacology (Elsevier) Brazil, USA, South Africa, 31 October 2020
Oncology
Key words: Esophageal Cancer, Purinergic System, Nucleotide, P2Y2R, Proliferation, Signaling Pathways [more]
Organism: Human
Tissue: Esophagus
Pathological State: Cancer
Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia–reperfusion injury
Journal of Advanced Research (Elsevier) China, 31 October 2020
Cardiology
Key words: Calenduloside E, Myocardial Ischemia-Reperfusion Injury, L-Type Calcium Channelscalcium Overload, Bcl2-Associated Athanogene 3 [more]
Organism: Rat
Tissue: Heart
Pathological State: Myocardial Ischemia
B Cell Activating Factor (BAFF) Is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats
International Journal of Molecular Sciences (MDPI) Germany, 28 October 2020
Nephrology
Key words: Tertiary Lymphoid Organs, Kidney Transplantation, B Cells, BAFF [more]
Organism: Rat
Tissue: Kidney
Pathological State: Organ Transplantation
Proteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model
Scientific Reports (Nature) Romania, 28 October 2020
Osteology
Key words: Bioinformatics, Biological Models, Fracture Repair, Immunological Techniques, Mass Spectrometry, Microscopy, Proteomic Analysis [more]
Organism: Human
Cell Line: Human mesenchymal stem cells (hMSCs)
Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma
The Journal of Pharmacology and Experimental Therapeutics (ASPET) UK, Austria, Australia, 28 October 2020
Pharmacology
Organism: Mouse
Tissue: Lung
Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model
CELL (Cell Press) USA, 27 October 2020
Neuroscience
Key words: Corticostriatal, Approach-Avoidance, Cost-Benefit, Decision-Making, Utility, Subjective Value, Motivation, Parvalbumin Interneurons, VGluT1, Excitation-Inhibition Balance [more]
Organism: Mouse
Tissue: Brain
Pathological State: Huntington's Disease
The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer
Cancers (MDPI) Austria, Switzerland, 25 October 2020
Oncology
Key words: Lymphoid Structures, Colonic Mucosa, Metastatic Colorectal Cancer, Immuno-Oncology, B Lymphocytes, Germinal Center, Tissue Image Cytometry, B-Cell Clonality, Compendium-Wide Analysis, Patient Stratification Strategy [more]
Organism: Human
Tissue: Colon
Pathological State: Cancer
Cross‐section modified and highly elastic sutures reduce tissue incision and show comparable biocompatibility: in‐vitro and in‐vivo evaluation of novel thermoplastic urethane surgical threads
Journal of Biomedical Materials Research: Part B (Wiley) Germany, 24 October 2020
Tissue Engineering
Key words: Animal Trials, Biocompatibility, Elastic Sutures, Surface Modified Surgical Threads, Thermoplastic Polyurethane, Tissue Incision [more]
Organism: Rat
Tissue: Stomach
Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo
Scientific Reports (Nature) USA, 23 October 2020
Immunology, Gastroenterology
Key words: Cytokines, Gastroenterology, Immunology, Inflammation, Inflammatory Bowel Disease [more]
Organism: Mouse
Cell Line: Mouse primary colonic fibroblasts
Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma
International Journal of Molecular Sciences (MDPI) Germany, 21 October 2020
Neuroscience
Key words: Lower-Grade Glioma, T-Cell Infiltration, TissueFAXS, Primary Tumors, Recurrent Tumors, Radiotherapy [more]
Organism: Human
Tissue: Brain
Pathological State: Cancer
Impaired autophagy increases susceptibility to endotoxin-induced chronic pancreatitis
Cell Death & Disease (Nature) Germany, 21 October 2020
Gastroenterology
Key words: Acute Pancreatitis, Chronic Pancreatitis [more]
Organism: Mouse
Tissue: Pancreas
Pathological State: Pancreatitis