Customer Publications (A total of 2600 papers published)

Freshwater cyanotoxin cylindrospermopsin has detrimental stage-specific effects on hepatic differentiation from human embryonic stem cells

Tereza Vanova, Jan Raska, Pavel Babica, Iva Sovadinova, Michaela Kunova Bosakova, Petr Dvorak Ludek Blaha, Vladimir Rotrekl

Toxicological Sciences (Oxford University Press) Czech Republic, 30 November 2018

Stem Cell Research

Key words: cylindrospermopsin, hepatic differentiation, human embryonic stem cells, liver, cyanotoxin [more]

Pterostilbene Attenuates Hexavalent Chromium-Induced Allergic Contact Dermatitis by Preventing Cell Apoptosis and Inhibiting IL-1β-Related NLRP3 Inflammasome Activation

Bour-Jr Wang, Hui-Wen Chiu, Yong-Lin Lee, Chia-Yi Li, Ying-Jan Wang, and Yu-Hsuan Lee

Journal of Clinical Medicine (MDPI) Taiwan, 27 November 2018

Allergy Research

Key words: Hexavalent chromium, pterostilbene, endoplasmic reticulum stress, inflammatory cytokines, NLRP3 inflammasome, allergic contact dermatitis [more]

ONECUT2 Is a Targetable Master Regulator of Lethal Prostate Cancer That Suppresses the Androgen Axis

Mirja Rotinen, Sungyong You, Julie Yang, Simon G Coetzee, Mariana Reis-Sobreiro, Wen-Chin Huang, Fangjin Huang, Xinlei Pan, Alberto Yáñez, Dennis J Hazelett, Chia-Yi Chu, Kenneth Steadman, Colm M Morrissey, Peter S Nelson, Eva Corey, Leland W K Chung, Stephen J Freedland, Dolores Di Vizio, Isla P Garraway, Ramachandran Murali, Beatrice S Knudsen & Michael R Freeman

Nature Medicine (Nature) USA, Taiwan, 26 November 2018

Oncology

Immune Cell and Cell Cluster Phenotyping, Quantitation, and Visualization Using In Silico Multiplexed Images and Tissue Cytometry

Kim RM Blenman, Marcus W Bosenberg

Cytometry Part A (Wiley) USA, 23 November 2018

Cytometry

Key words: immune cells, cell clusters, quantitative imaging, multiplexed histology, tissue cytometry, TissueFAXS in silico analysis, FFPE [more]

PD-L1 expression and the prognostic significance in gastric cancer: a retrospective comparison of three PD-L1 antibody clones (SP142, 28–8 and E1L3N)

Jing Ma, Jianhui Li, Meirui Qian, Weili Han, Miaomiao Tian, Zengshan Li, Zhe Wang, Shuixiang He and Kaichun Wu

Diagnostic Pathology (Springer) China, 21 November 2018

Oncology

Key words: Programmed cell death ligand 1, Immunohistochemistry, H-score, Multiplexed immunofluorescence [more]

MicroRNA-451a overexpression induces accelerated neuronal differentiation of Ntera2/D1 cells and ablation affects neurogenesis in microRNA-451a-/- mice

Christa Trattnig, Muammer Üçal, Carmen Tam-Amersdorfer, Angela Bucko, Ulrike Zefferer, Gerda Grünbacher, Markus Absenger-Novak, Kristin Anna Öhlinger, Klaus Kraitsy, Daniel Hamberger, Ute Schaefer, Silke Patz

PLoS One (PLOS) Austria, 21 November 2018

Neuroscience

Key words: Neuronal differentiation, Neurites, Cell differentiation, Neurospheres, MicroRNAs, Neural networks, Fluorescence microscopy, Nestin [more]

Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging

Annunziata N Crupi, Jordan S Nunnelee, David J Taylor, Amandine Thomas, Jean-Philippe Vit, Celine E Riera 5, Roberta A Gottlieb, Helen S Goodridge

Aging (Impact Journals) USA, 18 November 2018

Physiology

Key words: Aging, glycolytic, mitochondria, oxidative, sarcopenia, skeletal muscle [more]

Generation of human iPSCs from human prostate cancer-associated fibroblasts IBPi002-A

Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Daniela Kurfűrstová, Radek Vrtěl, Vladimír Študent, Lucie Jurečková, Volodymyr Porokh, Aleš Hampl, Karel Souček

Stem Cell Research (Elsevier) Czech Republic, 16 November 2018

Stem Cell Research

Key words: induced stem cells, iPSCs, prostate fibroblasts, IBPi00-2 [more]

Effect of dentin matrix components on the mineralization of human mesenchymal stromal cells

Dr Xenos Petridis, Mr Bas Pieter Beems, Dr Phillip Tomson, Dr Ben Scheven, Dr Ben Giepmans, Dr Jeroen Kuipers, Dr Luc van der Sluis, Dr Martin C Harmsen

Tissue Engineering Part A (Mary Ann Liebert Inc.) The Netherlands, UK, 16 November 2018

Regenerative Medicine

Key words: dental pulp, dentin matrix, mesenchymal stromal cells, mineralization, tissue engineering, umbilical cord [more]

Hepatocellular carcinoma-targeted nanoparticles for cancer therapy

Chien-Hsun Wu, Chun-Hsin Lan, Kuan-Lin Wu, Yao‑Ming Wu, Wann-Neng Jane, Michael Hsiao, Han-Chung Wu

International Journal of Oncology (Spandidos Publications) Taiwan, 16 November 2018

Oncology

[more]

Semi-Automated and Manual Methods for Counting Cells Expressing P75 Receptor in Endometriotic Lesions

Dewanto Agung, Sun Xiaoyan, Dudas Jozsef, Gluekert Rudolf, Schrott-Fischer Anneliese, W D Ludwig, Seeber Beata

International Conference on Science and Technology-Computer (ICST) () Indonesia, Austria, 12 November 2018

Cytometry

Key words: Observers, Immune system, Software, Lesions, Manuals, Biomedical imaging, Tools

Novel Protective Effects of Cistanche Tubulosa Extract Against Low-Luminance Blue Light-Induced Degenerative Retinopathy

Man-Ru Wua, Cheng-Hui Lina, Jau-Der Hob, George Hsiaoc, Yu-Wen Cheng

Cellular Physiology and Biochemistry (Karger) Taiwan, 07 November 2018

Ophthalmology

Key words: Cistanche tubulosa extract • Blue light • Apoptosis • Retinal pigment epithelial cells [more]

Increased frequency of systemic pro-inflammatory Vδ1+ γδ T cells in HIV elite controllers correlates with gut viral load

Gregory S Olson, Sarah W Moore, James M Richter, John J Garber, Brittany A Bowman, Crystal A Rawlings, Meaghan Flagg, Björn Corleis and Douglas S Kwon

Scientific Reports (Nature) USA, 07 November 2018

Immunology, Virology

Key words: Chronic inflammation, Gammadelta T cells, HIV infections, Infection, Mucosal immunology [more]

Loss of BAP1 expression is associated with genetic mutation and can predict outcomes in gallbladder cancer

Takashi Hirosawa, Masaharu Ishida, Kentaro Ishii, Keigo Kanehara, Katsuyoshi Kudo, Shinobu Ohnuma, Takashi Kamei, Fuyuhiko Motoi, Takeshi Naitoh, Florin M Selaru, Michiaki Unno

PLoS One (PLOS) Japan, USA, 05 November 2018

Oncology

Key words: DNA methylation, Small interfering RNAs, Polymerase chain reaction, Methylation, Mutation detection, Prognosis, DNA sequence analysis, Nonsense mutation [more]

Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice

Caroline Arnold, Anja Feldner, Maren Zappe, Dorde Komljenovic, Carolina De La Torre, Philipp Ruzicka, Markus Hecker, Wolfgang Neuhofer, and Thomas Korff

The FASEB Journal (FASEB) Germany, 01 November 2018

Regenerative Medicine

Key words: hypertension, wall stress, transcriptome [more]

Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow-and pressure-induced arterial remodeling in mice

Caroline Arnold, Anja Feldner, Maren Zappe, Dorde Komljenovic, Carolina De La Torre, Philipp Ruzicka, Markus Hecker, Wolfgang Neuhofer, and Thomas Korff

The FASEB Journal (FASEB) Germany, 01 November 2018

Cardiology

Key words: hypertension, wall stress, transcriptome [more]

Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis

Helen Ashwin, Karin Seifert, Sarah Forrester, Najmeeyah Brown, Sandy MacDonald, Sally James, Dimitris Lagos, Jon Timmis, Jeremy C Mottram, Simon L Croft, Paul M Kaye

Wellcome Open Research (Wellcome Open Research) UK, 29 October 2018

Parasitology

Key words: Leishmania, infection, host response, transcriptomics, immunopathology [more]

Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy

Ying Zhoua, Mrinmoy Maitib, Amit Sharmac, Miae Won, Le Yu, Lan Xi, Miao, Jinwoo Shin, Arup Podder, Kondapa Naidu Bobba, Jiyou Han, Sankarprasad Bhuniya, Jong Seung Kim

Journal of Controlled Release (Elsevier) China, India, South Korea, 28 October 2018

Oncology

Key words: molecular hypoxia, theranostic, tumor-specific imaging, [more]

PI3K: A master regulator of brain metastasis‐promoting macrophages/microglia

Raquel Blazquez Darius Wlochowitz Alexander Wolff Stefanie Seitz Astrid Wachter Julia Perera‐Bel Annalen Bleckmann Tim Beißbarth Gabriela Salinas Markus J Riemenschneider Martin Proescholdt Matthias Evert Kirsten Utpatel Laila Siam Bawarjan Schatlo Marko Balkenhol Christine Stadelmann Hans‐Ulrich Schildhaus Ulrike Korf Eileen Reinz Stefan Wiemann Elena Vollmer Mathias Schulz Uwe Ritter Uwe K Hanisch Tobias Pukrop

GLIA (Wiley) Germany, 25 October 2018

Oncology

Key words: Astrocytes, BKM120, brain metastasis, macrophages, microglia, PI3K, RPPA [more]

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Wei-TaChen, Wei-Tse Hsu, Meng-Hua Yen, Chun A Changou, Chia-Li Han, Yu-Ju Chen, Ji-Yen Cheng, Tzu-Hao Chang, Oscar Kuang-Sheng Lee, Jennifer Hui-Chun Ho

Biomaterials (Elsevier) Taiwan, 23 October 2018

Stem Cell Research

Key words: β-catenin, Cardiovascular, Laminar shear, Mesenchymal stem cells, Wnt [more]

Gene expression profiling in a mouse model of Dravet syndrom

Nicole AHawkins, Jeffrey DCalhoun, Alexandra MHuffman, Jennifer AKearney

Experimental Neurology (Elsevier) USA, 19 October 2018

Neuroscience

Key words: Epilepsy, Epileptic encephalopathy, Gene expression, RNA-seq, Seizure, Voltage-gated sodium channel [more]

Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation

Janaina M Alves, Antonio H Martins, Claudiana Lameu, Talita Glaser, Nawal M Boukli, Vinicius Bassaneze, Rafael Dariolli, Isis C Nascimento, Poliana C M Martins, Héllio D N de Souza, José Eduardo Krieger, Dulce E Casarini, Vicencia M Sales, João B Pesquero, Henning Ulrich

Stem Cell Reviews and Reports (Springer) USA, Brazil, 18 October 2018

Stem Cell Research

Key words: Mouse myoblast differentiation, Muscle repair, Kinin-B2 receptor, HOE-140 [more]

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

Mera vCohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit

CELL (Cell Press) Israel, Austria, Sweden, 11 October 2018

Cell Biology

Key words: immune systemsingle-cell RNA sequencinglungbasophilsalveolar macrophagescellular interactiondevelopmentsignaling [more]

Early Immunologic Response of Irreversible Electroporation versus Cryoablation in a Rodent Model of Pancreatic Cancer

Sarah B White, MD, MS, FSIR, Zhouli Zhang, MD, PhD, Jeane Chen, PhD, Venkateswara R Gogineni, PhD, and Andrew C Larson, PhD

Journal of Vascular and Interventional Radiology (Elsevier) USA, 11 October 2018

Immunology

Key words: irreversible electroporation, Cryoablation, Pancreatic Cancer [more]

Transforming growth factor beta 1 mediates the low-frequency vertical vibration enhanced production of tenomodulin and type I collagen in rat Achilles tendon

Chia-Hsin Chen, Yi-Hsiung Lin, Chung-Hwan Chen, Yan-Hsiung Wang, Ming-Long Yeh, Tsung-Lin Cheng, Chau-Zen Wang

PLoS One (PLOS) Taiwan, 11 October 2018

Cell Biology

Key words: Tendons, Collagens, Gene expression, Stiffness, Vibration, Mechanical properties, Enzyme-linked immunoassays, Polymerase chain reaction [more]

Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis

Yang WH, Heithoff DM, Aziz PV, Haslund-Gourley B, Westman JS, Narisawa S, Pinkerton AB, Millán JL, Nizet V, Mahan MJ, Marth JD

Cell Host and Microbe (Cell Press) USA, 10 October 2018

Immunology, Microbiology

Key words: glycosylation, sepsis, neuraminidase, Toll-like receptor 4, alkaline phosphatase, Ashwell-Morell receptor, lipopolysaccharide, inflammation [more]

Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors

Hye Jung Baek, Sun Eui Kim, Jong Kwang Kim, Dong Hoon Shin, Tae Hyun Kim, Kwang Gi Kim, Chu-Xia Deng, Sang Soo Kim

International Journal of Biological Sciences (Ivyspring International Publisher) South Korea, China, 10 October 2018

Oncology

Key words: BRCA1, AKT, MK-2206, precision medicine [more]

Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells

Kang-Hao Liang, Hsien-Cheng Tso, Shao-Hsi Hung, I-I Kuan, Jun-Kai Lai, Feng-Yi Ke, Yi-Ting Chuang, I-Ju Liu, Yi-Ping Wang, Ruey-Hwa Chen, Han-Chung Wu

Cancer Letters (Elsevier) Taiwan, 01 October 2018

Oncology

Key words: Epithelial cell adhesion molecule, Regulated intramembrane proteolysis, β-catenin, HIF1α [more]

Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

Quan-Liang Jian​, Wei-Chun HuangFu​, Yen-Hua Lee, I-Hsuan Liu​

The Journal of Life and Environmental Sciences (PeerJ) Taiwan, 01 October 2018

Osteology

Key words: Aging,  Cartilage,  Osteoarthritis,  Tissue homeostasis,  Chondrocyte [more]

Gd-EOB-DTPA DCE-MRI biomarkers in a rabbit model of liver fibrosis

Yang Ji, Chuanshan Zhang, Zhe Huang, Xia Wang, Lina Yue, Meimei Gao, Huiling Hu, Qinjun Su, Yuedong Han, Bin Liu, Ding Yang, Zhanliang Su, Zhuoli Zhang

American Journal of Translational Research (e-Century Publishing Corporation) China, USA, 30 September 2018

Hepathology

Key words: Liver fibrosis, animal, magnetic resonance imaging, pathology [more]

Modified Ginseng Extract Induces Apoptosis in HepG2 Cancer Cells by Blocking the CXCL8-Mediated Akt/Nuclear Factor-κB Signaling Pathway

Zhen Yang Cui, Eunbi Jo, Hyun Jin Jang, In-Hu Hwang, Kyung-Bok Lee, Hwa-Seung Yoo, Soo Jung Park, Mi-Kyung Jung, Yeon Wol Lee and Ik-Soon Jang

The American Journal of Chinese Medicine (World Scientific) South Korea, 27 September 2018

Oncology

Key words: Modified Regular Ginseng Extract, MRGX, C-X-C Motif Chemokine Ligand 8, Liver Cancer, Akt, Nuclear Factor-κB, Apoptosis [more]

Development of Decellularized Cornea by Organic acid Treatment for Corneal Regeneration

Mr HungJun Lin, Dr TsungJen Wang, Miss TingWei Li, Dr YaoYuan Chang, Prof Ming Thau Sheu, Prof Yi-You Huang, Dr Der-Zen Liu

Tissue Engineering Part A (Mary Ann Liebert Inc.) Taiwan, 22 September 2018

Regenerative Medicine

Key words: cornea, decellularized scaffold, extracellular matrix, xenograft, corneal transplantation. [more]

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

Jacqueline A Brosnan-Cashman, Ming Yuan, Mindy K Graham, Anthony J Rizzo, Kaylar M Myers, Christine Davis, Rebecca Zhang, David M Esopi, Eric H Raabe, Charles G Eberhart, Christopher M Heaphy, Alan K Meeker

PLoS One (PLOS) USA, 18 September 2018

Oncology

Key words: Telomeres, Cloning, Glioma cells, Glioma, DNA cloning, Immunoblotting, Vector cloning, Polymerase chain reaction [more]

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

Bohumil Fafilek, Lukas Balek, Michaela Kunova Bosakova, Miroslav Varecha, Alexandru Nita, Tomas Gregor, Iva Gudernova, Jitka Krenova, Somadri Ghosh, Martin Piskacek, Lucie Jonatova, Nicole H Cernohorsky, Jennifer T Zieba, Michal Kostas, Ellen Margrethe Haugsten, Jørgen Wesche, Christophe Erneux, Lukas Trantirek, Deborah Krakow, and Pavel Krejc

Science Signaling (American Association for the Advancement of Science) Czech Republic, Belgium, USA, Norway, 18 September 2018

Cell Biology

Key words: SHIP2, ERK activation, FGF receptors, Src kinases [more]

Activation of estrogen receptor alpha induces beiging of adipocytes

Roberta SSantos, Aaron PFrank, Luciana AFátima, Biff FPalmer, Deborah JClegg

Molecular Metabolism (Elsevier) USA, 15 September 2018

Cell Biology

Key words: Beige adipocytes, Lipolysis, Estrogen receptor alpha (ERα), Obesity, Type II diabetes mellitus (T2DM) [more]

Cellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model

Helen N Schwerdt, Elizabeth Zhang, Min Jung Kim, Tomoko Yoshida, Lauren Stanwicks, Satoko Amemori, Huseyin E Dagdeviren, Robert Langer, Michael J Cima and Ann M Graybiel

Communications Biology (Nature) USA,, 12 September 2018

Neuroscience

Key words: Diagnostic markers, Neurochemistry, Parkinson's disease, Sensors and probes [more]

Synthetic α5β1 integrin ligand PHSRN is proangiogenic and neuroprotective in cerebral ischemic stroke

Cheng-Chun Wu, Liang-Chao Wang, Yu-Tin Su, Wei-Yen Wie, Kuen-Jer Tsai

Biomaterials (Elsevier) Taiwan, 11 September 2018

Biological Materials

Key words: Stroke, Fibronectin, PHSRN, α5β1, Angiogensis, Neurogenesis, VEGF [more]

Factor Xa inhibition by rivaroxaban regulates fibrogenesis in human atrialfibroblasts with modulation of nitric oxide synthesis and calciumhomeostasis

Cheng-Chih Chung, Yung-Kuo Lin, Yao-Chang Chen, Yu-Hsun Kao, Yung-Hsin Yeh, Yi-Jen Chen

Journal of Molecular and Cellular Cardiology (Elsevier) Taiwan, 10 September 2018

Physiology

Key words: Fibroblasts, Fibrosis, Rivaroxaban, Protease-activated receptor, Atrial fibrillation, Stroke [more]

Phenethyl Isothiocyanate Inhibits In Vivo Growth of Xenograft Tumors of Human Glioblastoma Cells

Yu-Cheng Chou, Meng-Ya Chang, Hsu-Tung Lee, Chiung-Chyi Shen, Tomor Harnod, Yea-Jiuan Liang, Rick Sai-Chuen Wu, Kuang-Chi Lai, Fei-Ting Hsu, Jing-Gung Chung

Molecules (MDPI) Taiwan, 10 September 2018

Oncology

Key words: phenethyl isothiocyanate, apoptosis, xenograft, caspase, glioblastoma [more]

Androgen receptor expression inversely correlates with immune cell infiltration in human epidermal growth factor receptor 2–positive breast cancer

Johan M van Rooijen, Si-Qi Qiu, Hetty Timmer-Bosscha, Bert van der Vegt, James E Boers, Carolien P Schröder, Elisabeth GE de Vries

European Journal of Cancer (Elsevier) The Netherlands, China, 09 September 2018

Oncology

Key words: Androgen receptor expression, HER2-positive metastatic breast cancer, Immune cell infiltration, Trastuzumab resistance [more]

TLR7 agonist attenuates acetylcholine‐induced, Ca2+‐dependent ionic currents in swine tracheal submucosal gland cells

Shunichi Gamo, Tsutomu Tamada, Koji Murakami, Soshi Muramatsu, Hidemi Aritake, Masayuki Nara, Itsuro Kazama, Tatsuma Okazaki, Hisatoshi Sugiura, Masakazu Ichinose

Experimental Physiology (Wiley) Japan, 08 September 2018

Physiology

Key words: CaCC, COPD, hypersecretion, R837, submucosal glands [more]

Inhibitory control of prefrontal cortex by the claustrum

Jesse Jackson, Mahesh M Karnani, Boris V Zemelman, Denis Burdakov, Albert K Lee

Neuron (Cell Press) USA, UK, Canada, 05 September 2018

Neuroscience

Key words: claustrum prefrontal NPY PV neocortex feed-forward inhibition microcircuit neurogliaform cell somatostatin interneuron VIP [more]

Oxidized Low-Density Lipoprotein-Deteriorated Psoriasis Is Associated with the Upregulation of Lox-1 Receptor and Il-23 Expression In Vivo and In Vitro

Chun-Ming Shih, Chien-Yu Huang, Kuo-Hsien Wang, Chun-Yao Huang, Po-Li Wei, Yu-Jia Chang, Chi-Kun Hsieh, Kuan-Ting Liu, Ai-Wei Lee

International Journal of Molecular Sciences (MDPI) Taiwan, 03 September 2018

Dermatology

Key words: oxLDL,  LOX-1,  psoriasis [more]

Enhanced Sternal Healing via Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel

Masafumi Shibata, Gen Takagi, Mitsuhiro Kudo, Jiro Kurita, Yoko Kawamoto, Yasuo Miyagi, Mikimoto Kanazashi, Takashi Sakatani, Zenya Naito, Yasuhiko Tabata, Masaaki Miyamoto, and Takashi Nitta

Tissue Engineering Part A (Mary Ann Liebert Inc.) Japan, 01 September 2018

Regenerative Medicine

[more]

Amentoflavone Inhibits Hepatocellular Carcinoma Progression Through Blockage of ERK/NF-ĸB Activation

Kun-Ching Lee, Wei-Ting Chen, Yu-Chang Liu, Song-Shei Lin, Fei-Ting Hsu

in vivo: international journal of experimental and clinical pathophysiology and drug research (International Institute of Anticancer Research) Taiwan, 01 September 2018

Oncology

Key words: Amentoflavone, hepatocellular carcinoma, extracellular signal-regulated kinase, nuclear factor-kappaB, bioluminescence imaging. [more]

The tree shrew cerebellum atlas: Systematic nomenclature, neurochemical characterization and afferent projections

Rong‐Jun Ni Zhao‐Huan Huang Peng‐Hao Luo Xiao‐Hong Ma Tao Li Jiang‐Ning Zhou

Journal of Comparative Neurology (Wiley) China, 29 August 2018

Neuroscience

Key words: cerebellar nuclei, lobule fissure, inferior olive, Purkinje cell, calbindin, RRID: AB_476894 [more]

Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction

Po-Hung Hsu, Ya-Tin Lin, Yi-Hsiu Chung, Kun-Ju Lin, Liang-Yo Yang, Tzu-Chen Yen and Hao-Li Liu

Scientific Reports (Nature) Taiwan, 27 August 2018

Neuroscience

Key words: Alzheimer's disease, eBiomedical engineering, Blood–brain barrier, Drug delivery, Translational research, GSK-3, Amyloid-Beta Plaque [more]

Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats

Shang-Cheng Huang, Tzu-Ling Li, Yen-Hsien Lee, Yu-Wen E Dai, Yu-Chun Chen Ling-Ling Hwang

Scientific Reports (Nature) Taiwan, 23 August 2018

Cardiology

Key words: Hypertension, Hypothalamus [more]

NFAT5 isoform C controls biomechanical stress responses of vascular smooth muscle cells

Maren Zappe, Anja Feldner, Caroline Arnold, Carsten Sticht, Markus Hecker and Thomas Korff

Frontiers in Physiology (Frontiers Media S.A.) Germany, 23 August 2018

Cardiology

Key words: NFAT5, TonEBP, hypertension, transcriptional regulation, vascular smooth muscle cells, wall stress [more]

Photoperiodic Flower Mimicking Metallic Nanoparticles for Image-Guided Medicine Applications

S Cho, B Lee, W Park, X Huang, DH Kim

ACS Applied Materials & Interfaces (ACS Publications) USA, 22 August 2018

Radiotherapy

Key words: metallic nanoparticles, radiosensitizers, image-guided radiotherapy, radiation, cancer therapy [more]

Optimization of an Anti-NMDA Receptor Autoantibody Diagnostic Bioassay

NC Chiu, YJ Lin, RF Tzang, YS Li, HJ Lin, S Das, CG Chen, CC Chen, K Hsu

Circulation (NCBI) Taiwan, Denmark, Sweden, 22 August 2018

Neuroscience

Key words: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, autoantibody (autoAb), autoimmune encephalitis, schizophrenia, diagnostic test, fluorescein isothiocyanate (FITC), Alexa Fluor 488, antigen (Ag) [more]

Lack of DNA damage response at low radiation doses in adult stem cells contributes to organ dysfunction

Peter W Nagle, Nynke A Hosper, Lara Barazzuol, Anne L Jellema, Mirjam Baanstra, Marc-Jan van Goethem, Sytze Brandenburg, Ulrich Giesen, Johannes A Langendijk, Peter van Luijk and Rob P Coppes

Clinical Cancer Research (AACR Publications) The Netherlands, 22 August 2018

Oncology

Key words: DNA Damage, Radiation, Stem Cells, Organ Dysfunction, Radiotherapy [more]

Striatal Microstimulation Induces Persistent and Repetitive Negative Decision-Making Predicted by Striatal Beta-Band Oscillation

Ken-ichi Amemori, Satoko Amemori,Daniel J Gibson and Ann M Graybie

Neuron (Cell Press) USA, 22 August 2018

Neuroscience

Key words: approach-avoidance conflict, basal ganglia, beta oscillation, caudate nucleus, cost-benefit decisions, emotion, macaque, motivation, primate, value judgment [more]

Modified Methacrylate Hydrogels Improve Tissue Repair after Spinal Cord Injury

Aleš Hejčl, Jiří Růžička, Kristýna Kekulová 1, Barbora Svobodová, Vladimír Proks, Hana Macková, Kateřina Jiránková, Kristýna Kárová, Lucia Machová Urdziková, Šárka Kubinová, Jiří Cihlář, Daniel Horák and Pavla Jendelová

International Journal of Molecular Sciences (MDPI) Czech Republic, 22 August 2018

Regenerative Medicine

Key words: spinal cord injury, hydrogel, connective tissue, neurofilaments, locomotor test, plantar test [more]

Secreted products of oral bacteria and biofilms impede mineralization of apical papilla stem cells in TLR-, species-, and culture-dependent fashion

Xenos Petridis,Luc W M van der Sluis,1 René J B Dijkstra,1 Marja G L Brinker, Henny C van der Mei,and Martin C Harmsen

Scientific Reports (Nature) The Netherlands, 21 August 2018

Immunology, Microbiology

Key words: Mesenchymal stem cells, Oral diseases, biofilms [more]

Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature

Tej Pratap Singh,Pablo A Vieyra-Garcia,Karin Wagner,Josef Penninger,Peter Wolf

Cell Death & Disease (Nature) Austria, 06 August 2018

Oncology

Key words: Cbl-b deficiency, UVB, skin damage, inflammation, gene signature [more]

Expression and modulation of S100A4 protein by human mast cells

Rossana Domenis, David Pilutti, Maria Orsaria, Stefania Marzinotto, Veronica Candotti, Giulia Bosisio, Michela Bulfoni, Maria Elisabetta Ruaro, Carla Di Loreto, Vincenzo Della Mea, Eleonora Toffoletti, Ambrogio PLondero, Laura Mariuzzi, Giorgia Gri

Cellular Immunology (Elsevier) Italy, 04 August 2018

Immunology

Key words: Immunofluorescence Tryptase Metalloproteinase Mast cells biology siRNA [more]

Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine

Chang‐Bin Liu De‐Gang Yang Xin Zhang Wen‐Hao Zhang Da‐Peng Li Chao Zhang Chuan Qin Liang‐Jie Du Jun Li Feng Gao Jie Zhang Zhen‐Tao Zuo Ming‐Liang Yang Jian‐Jun Li

CNS Neuroscience and Therapeutics (Wiley) China, 03 August 2018

Neuroscience

Key words: canine model, diffusion tensor imaging, gray matter, pathological degeneration, spinal cord injury, white matter [more]

Crumpled Aluminum Hydroxide Nanostructures as a Microenvironment Dysregulation Agent for Cancer Treatment

MI Lerner, G Mikhaylov, AA Tsukanov, Aleksandr S Lozhkomoev, Elazar Gutmanas, Irena Gotman, Andreja Bratovs, Vito Turk‡ Boris Turk, Sergey G Psakhye, and Olga Vasiljeva

Nano Letters (ACS Publications) Russia, Israel, Slovenia, 02 August 2018

Nanomedicine

Key words: aluminum hydroxide, cancer treatment, Crumpled nanosheets, ion balance, molecular dynamics simulation, tumor microenvironment [more]

Plk1 overexpression suppresses tumor development by inducing chromosomal instability

Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañés, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres and Rocío Sotillo

Nature Communications (Nature) Spain, Germany, UK, 01 August 2018

Oncology

Key words: Cancer, Cell biology [more]

SCID/NOD mice model for 5-FU induced intestinal mucositis: Safety and effects of probiotics as therapy

LawrenceHuangabJen-ShiuChiang ChiaucMei-LienChengcWai-TaoChanaChuen-BinJiangadSzu-WenChangaChun-YanYeungaeHung-ChangLee

Pediatrics and Neonatology (Elsevier) Taiwan, 26 July 2018

Gastroenterology

Key words: SCID, cytokines, fluorouracil, mucositis, probiotics [more]

Trehalose to cryopreserve human pluripotent stem cells

Aikaterini Ntaia , Alberto La Spadab , Pasquale De Blasioa , Ida Biunno

Stem Cell Research (Elsevier) Italy, 25 July 2018

Stem Cell Research

Key words: Cryopreservation, Trehalose, Pluripotent stem cells [more]

Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells

YT Wu, KT Chi, YW Lan, JC Chan, YS Ma, YH Wie

Free Radical Research (Taylor and Francis) Taiwan, 23 July 2018

Stem Cell Research

Key words: Adipogenesis, antioxidant defence, human mesenchymal stem cells, insulin resistance, mitochondrial bioenergetics, Sirt3 [more]

Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells

Anja Weber,Helmut Klocker,Herbert Oberacher,Erich Gnaiger,Hannes Neuwirt,Natalie Sampson and Iris E Eder

International Journal of Molecular Sciences (MDPI) Austria, 21 July 2018

Oncology

Key words: Na+-dicarboxylate transporter, acidic tumor microenvironment, mitochondria, oxidative phosphorylation, prostate cancer, succinate [more]

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Mario Mauthe, Idil Orhon, Cecilia Rocchi, Xingdong Zhou, Morten Luhr, Kerst-Jan Hijlkema, Robert P Coppes, Nikolai Engedal, Muriel Mari and Fulvio Reggiori

Autophagy (Taylor and Francis) The Netherlands, 20 July 2018

Cell Biology

Key words: Autophagy, Golgi, bafilomycin A1, degradative compartments, fusion, lysosomal degradation, lysosomal inhibitors [more]

Prognostic and predictive values of immune infiltrate in patients with head and neck squamous cell carcinoma

Xue-MeiZhang Ling-JunSong JuanShenHao YueYa-QinHanChen LingYangShi YunLiuJia WenDengYue JiangGuo HuiFu

Human Pathology (Elsevier) China, 20 July 2018

Oncology

Key words: Head and Neck Squamous Cell Carcinoma, Immunoscore, Prognosis and Predictive, Tumor Infiltrating Lymphocytes [more]

Significant therapeutic effects of adult human multipotent neural cells on spinal cord injury

KH Lee, HJ Pyeon, H Nam, JS Won, JY Hwang, KA Lee, JY Yeon, SC Hong, DH Nam, K Lee, SH Lee, KM Joo

Stem Cell Research (Elsevier) South Korea, 19 July 2018

Stem Cell Research

Key words: Spinal cord injuries, Adult stem cells, Neural stem cells, Microvasculature, Chemokine1 [more]

Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition

Ján Remšík Lucia Binó Zuzana Kahounová Gvantsa Kharaishvili Šárka Šimečková Radek Fedr Tereza Kučírková Sára Lenárt Ximena Maria Muresan Eva Slabáková

Carcinogenesis (Oxford University Press) Czech Republic, 16 July 2018

Oncology

Key words: phenotype, cancer, carcinoma, epithelium, heterogeneity, antigens, cell lines, membrane glycoproteins, breast, neoplasms, prostate, transcription factor, prostate cancer, carcinogenesis, e-cadherin, tumor progression, epithelial to mesenchymal transition, molecular targeted therapy, tumor cells, malignant [more]

Enhancement of chondrogenesis of adipose-derived stem cells in HA-PNIPAAm-CL hydrogel for cartilage regeneration in rabbits

Chau-Zen Wang,Rajalakshmanan Eswaramoorthy,Tzu-Hsiang Lin,Chung-Hwan Chen,Yin-Chih Fu,Chih-Kuang Wang,Shun-Cheng Wu,Gwo-Jaw Wang, Je-Ken Chang,corresponding author Mei-Ling Ho

Scientific Reports (Nature) Taiwan, 12 July 2018

Regenerative Medicine

Key words: Biomaterials, Regeneration, hydrogel, cartilage [more]

Synergistic Cross‐Talk of Hedgehog and Interleukin‐6 Signaling Drives Growth of Basal Cell Carcinoma

Christina Sternberg Wolfgang Gruber Markus Eberl Suzana Tesanovic Manuela Stadler Dominik P Elmer Michaela Schlederer Sandra Grund Simone Roos

International Journal of Cancer (Wiley) Austria, 10 July 2018

Oncology

Key words: GLI signaling, GLI transcription factors, STAT transcription factors, basal cell carcinoma, hedgehog, interleukin-6 signaling [more]

Expression of serine peptidase inhibitor Kunitz type 1 in differentiated thyroid cancer

Chien-Liang LiuPo-Sheng YangMing-Nan ChienYuan-Ching ChangChi-Hsin LinShih-Ping Cheng

Histochemistry and Cell Biology (Springer) Taiwan, 10 July 2018

Oncology

Key words: Serine protease inhibitor, Hepatocyte growth factor, Thyroid cancer Invasion [more]

TERT Promoter Mutations in Solitary Fibrous Tumor

Elizabeth G Demicco Khalida Wani Davis Ingram Michael Wagner Robert G Maki Anthony Rizzo Alan Meeker Alexander J Lazar Wei‐Lien Wang

HistoPathology (Wiley) USA, 09 July 2018

Oncology

Key words: ATRX, DAXX, metastasis, outcome, prognosis, risk assessment, solitary fibrous tumour, telomerase reverse transcriptase [more]

Development of a Novel Orthogonal Double Gradient for High‐Throughput Screening of Mesenchymal Stem Cells–Materials Interaction

Qihui Zhou Lu Ge Carlos F Guimarães Philipp T Kühn Liangliang Yang Patrick van Rijn

Advanced Materials Interfaces (Wiley) The Netherlands, 04 July 2018

Biological Materials

Key words: high‐throughput screening, orthogonal double gradient, stem cell, stiffness, wettability [more]

Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo

Yi‐Shih Ma Jen‐Jyh Lin Chin‐Chung Lin Jin‐Cherng Lien Shu‐Fen Peng Ming‐Jen Fan Fei‐Ting Hsu Jing‐Gung Chung

Environmental Toxicology (Wiley) Taiwan, 04 July 2018

Oncology

Key words: benzyl isothiocyanate, human brain glioblastoma multiforme GBM 8401 cell, in vivo, nude mice, xenograft tumor [more]

Antrodia cinnamomea produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway

Tsung-TengHuang Ying-WeiLan Yun-FeiKo Chuan-MuChen Hsin-ChihLaijkDavid MOjcius JanMartel John DYoung Kowit-YuChong

Journal of Ethnopharmacology (Elsevier) Taiwan, 28 June 2018

Cell Biology

Key words: Antrodia cinnamomea, Anti-angiogenic activity, Endothelial cells, VEGFR2, STAT3 [more]

Dynamics of tissue ingrowth in SIKVAV-modified highly superporous PHEMA scaffolds with oriented pores after bridging a spinal cord transection

Aleš Hejčl, Jiří Růžička Vladimír Proks, Hana Macková, Šárka Kubinová Dmitry Tukmachev,Jiří Cihlář Daniel Horák Pavla Jendelová

Journal of Materials Science: Materials in Medicine (Springer) Czech Republic, 25 June 2018

Regenerative Medicine

Key words: tissue ingrowth, SIKVAV, superporous, PHEMA scaffolds, oriented pores, spinal cord injury, mesenchymal stem cells (MSCs) [more]

Neuroplastic change of cytoskeleton in inferior colliculus after auditory deafferentation

Jae JoonHanaHo SunLeebcMin-HyunPark

Hearing Research (Elsevier) South Korea, 23 June 2018

Neuroscience

Key words: Auditory deafferentation, Deafness, SMI-32, Neurofilament heavy chain, Inferior colliculus [more]

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes

Guadalupe Navarro, Camille Allard, Jamie J Morford, Weiwei Xu, Suhuan Liu, Adrien JR Molinas, Sierra M Butcher, Nicholas HF Fine, Manuel Blandino-Rosano, Venkata N Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A Jacobson, Prasad V Katakam,David J Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok,and Franck Mauvais-Jarvis

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 21 June 2018

Oncology

Key words: Beta cells, Diabetes, Endocrinology, Metabolism, Sex hormones [more]

Afatinib restrains K-RAS–driven lung tumorigenesis

Herwig P Moll, Klemens Pranz, Monica Musteanu, Beatrice Grabner, Natascha Hruschka, Julian Mohrherr

Science Translational Medicine (American Association for the Advancement of Science) Austria, 20 June 2018

Oncology

Key words: Afatinib, K-RAS, lung cancer, pan-ERBB, tyrosine kinase inhibitors [more]

Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis

Kumud RPoudel MinnaRoh-Johnson AllenSu ThuongHo HarithaMathsyaraja SarahAnderson William MGrady Cecilia BMoens MaraliceConacci-Sorrell Robert NEisenman

Developmental Cell (Cell Press) USA, 18 June 2018

Oncology

Key words: BAR domain, PTEN, Rac1, TIAM1, cell migration, endocytosis, endophilin, membrane remodeling, metastasis [more]

Endothelial colony forming cells from human umbilical cord blood improved severe erectile dysfunction in obese type II diabetic rats

Abrar Al-Mahmood Siddiqueea , P Ganesan Adaikana, , Lang Chu Laua , Baharudin Bin Saida , Mark Chongb , Jerry Chanc , Swee Hin Teoh

Life Science (Elsevier) Singapore, 18 June 2018

Reproductive Medicine

Key words: Severe erectile dysfunction, Human endothelial colony forming cells, Intracavernosal pressure, Zucker diabetic fatty rats [more]

Quantitative measurement of breast carcinoma fibrosis for the prediction in the risk of bone metastasis

Chong Sun, Bin Wang, Jianmin Li, Junjie Shangguan, Matteo Figini, Kang Zhou, Liang Pan, Quanhong Ma, Zhuoli Zhang

American Journal of Translational Research (e-Century Publishing Corporation) China, 15 June 2018

Oncology

Key words: Invasive breast carcinoma, bone metastasis, collagen deposition, early prediction [more]

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

Sander C Steenbeek, Thang V Pham, Joep de Ligt, Anoek Zomer, Jaco C Knol, Sander R Piersma, Tim Schelfhorst, Rick Huisjes, Raymond M Schiffelers, Edwin Cuppen, Connie R Jimenez, Jacco van Rheenen

EMBO Journal (EMBO press) The Netherlands, 15 June 2018

Oncology

Key words: Cre‐LoxP, extracellular vesicles, intratumoral heterogeneity, intravital microscopy, signaling networks [more]

Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts

Tanja Niedermair, Stephan Schirner, Raphael Seebröker, Rainer H Straub, Susanne Grässel

Scientific Reports (Nature) Germany, 15 June 2018

Physiology

Key words: Substance P, bone remodeling, osteoblasts, osteoclasts, Bone, Mechanisms of disease [more]

Synergistic Antitumor Effect of Oligogalacturonides and Cisplatin on Human Lung Cancer A549 Cells

Cian-Song Huang, Ai-Chun Huang, Ping-Hsiu Huang, Diana Lo, Yuh-Tai Wang, Ming-Chang Wu

International Journal of Molecular Sciences (MDPI) Taiwan, 14 June 2018

Oncology

Key words: adjuvant therapy, cisplatin, oligogalacturonides, synergistic effect [more]

Nerve Growth Factor (NGF)—Receptor Survival Axis in Head and Neck Squamous Cell Carcinoma

József Dudás, Wolfgang Dietl, Angela Romani, Susanne Reinold, Rudolf Glueckert, Anneliese Schrott-Fischer, Daniel Dejaco, Lejo Johnson Chacko, Raphaela Tuertscher, Volker Hans Schartinger, Herbert Riechelmann

International Journal of Molecular Sciences (MDPI) Austria, 14 June 2018

Oncology

Key words: TissueFaxs, cell cycle arrest, cytokeratin, necrosis [more]

Breast Cancer Histological Image Classification Using Fine-Tuned Deep Network Fusion

A Mahbod, I Ellinger, R Ecker, Ö Smedby, C Wang

International Conference Image Analysis and Recognition (Springer) , 06 June 2018

Key words: Breast cancer Histological images Classification Deep learning

Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

Somayyeh Hamzei Taj, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Alessandra Quarta, Jelle Praet, Annemie Van der Linden, Peter Ponsaerts, Mathias Hoehn

Journal of Neuroinflammation (Springer) Germany, 04 June 2018

Immunology

Key words: Interleukin 13, Mesenchymal stem cells, Microglia/macrophage polarization, Neuroinflammation, Stroke [more]

Novel Conducting and Biodegradable Copolymers with Noncytotoxic Properties toward Embryonic Stem Cells

Aruã C da Silva, Ana Teresa S Semeano, André H B Dourado, Henning Ulrich, Susana I Cordoba de Torresi

ACS OMEGA (ACS Publications) Brazil, 31 May 2018

Stem Cell Research

Key words: Cell and Molecular biology, Conducting polymers, Environmental biology, Polyesters [more]

Hierarchical Multiplexing Nanodroplets for Imaging-Guided Cancer Radiotherapy via DNA Damage Enhancement and Concomitant DNA Repair Prevention

Wei Jiang, Quan Li, Liang Xiao, Jiaxiang Dou, Yi Liu, Wenhao Yu, Yinchu Ma, Xiaoqiu Li, Ye-Zi You, Zhuting Tong, Hang Liu, Hui Liang, Ligong Lu, Xiaoding Xu, Yandan Yao, Guoqing Zhang, Yucai Wang, and Jun Wang

ACS NANO (ACS Publications) China, 29 May 2018

Nanomedicine

Key words: cancer radiotherapy, DNA damage and repair, hierarchical nanostructure, multimodal imaging, tumor hypoxia [more]

Acellular vascular matrix grafts from human placenta chorion: Impact of ECM preservation on graft characteristics, protein composition and in vivo performance

Karl H Schneider, Marjan Enayati, Christian Grasl, Ingrid Walter, Lubos Budinsky, Gabriel Zebic, Christoph Kaun, Anja Wagner, Klaus Kratochwill, Heinz Redl, Andreas Teuschl, Bruno K Podesser, Helga Bergmeister

Biomaterials (Elsevier) Austria, 29 May 2018

Regenerative Medicine

Key words: Decellularized matrix, Human placenta, Small diameter vascular grafts, Cell migration, Biocompatibility [more]

Identification of galectin-3 as an autoantigen in patients with IgG4-related disease

Cory A Perugino, Sultan B AlSalem, Hamid Mattoo, Emanuel Della-Torre, Vinay Mahajan, Gayathri Ganesh, Hugues Allard-Chamard, Zachary Wallace, Sydney B Montesi, Johannes Kreuzer, Wilhelm Haas, John H Stone, Shiv Pillai

Journal of Allergy and Clinical Immunology (Elsevier) UK, USA, Italy, 29 May 2018

Immunology

Key words: IgG4-related disease, plasmablast, autoantigen, galectin-3, autoantibody [more]

Allocation of Interferon Gamma mRNA Positive Cells in Caecum Hallmarks a Protective Trait Against Histomonosis

Fana Alem Kidane, Taniya Mitra, Patricia Wernsdorf, Michael Hess, Dieter Liebhart

Frontiers in Immunology (Frontiers Media S.A.) Austria, 28 May 2018

Immunology

Key words: Histomonas meleagridis, histomonosis, image analysis, immunofluorescence, in situ hybridization, interferon gamma, interleukin-13, vaccination [more]

The overexpression of Fra1 disorders the inflammatory cytokine secretion by mTEC of myasthenia gravis thymus

Q‐R Li W‐P Ni N‐J Lei J‐Y Yang X‐Y Xuan P‐P Liu G‐M Gong F Yan Y‐S Feng R Zhao Y Du

Scandinavian journal of Immunology (Blackwell Publishing Inc.) China, 28 May 2018

Neuroscience

Key words: Fos-related antigen-1, inflammatory cytokine, medulla thymic epithelial cells, myasthenia gravis [more]

Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke

Ewelina Kurtys Cindy Casteels Caroline C Real Ulrich L M Eisel J Martin Verkuyl Laus M Broersen Hans C Klein Rudi A J O Dierckx Janine Doorduin Erik F J de Vries

CNS Neuroscience and Therapeutics (Wiley) The Netherlands, 27 May 2018

Neuroscience

Key words: PET imaging, neuroinflammation, nutrition, photothrombotic stroke [more]

Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI-PEG20 treatment in CCA cell lines

Somphon Roeksomtawin, Panida Navasumrit, Somchamai Waraprasit, Varabhorn Parnlob, Thaniya Sricharunrat, Vajarabhongsa Bhudhisawasdi, Niramol Savaraj, Mathuros Ruchirawat

Oncology Letters (Spandidos Publications) Thailand, 24 May 2018

Oncology

Key words: Ki-67, arginine deprivation, argininosuccinate synthetase, cholangiocarcinoma, pegylated arginine deiminase [more]

Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway

Zhen Yang Cui, Soo Jung Park, Eunbi Jo, In-Hu Hwang, Kyung-Bok Lee, Sung-Woo Kim, Dae Joon Kim, Jong Chun Joo, Seok Hoon Hong, Min-Goo Lee and Ik-Soon Jang

Cell Death Discovery (Nature) South Korea, USA, 23 May 2018

Oncology

[more]

BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling

Yueh-Hua Chung, Ying-Hsien Huang, Tien-Huei Chu, Chun-Lin Chen, Pey-Ru Lin, Shih-Chung Huang, Deng-Chyang Wu, Chao-Cheng Huang, Tsung-Hui Hu, Ying-Hsien Kao and Ming-Hong Tai

Laboratory Investigation (Nature) Taiwan, 22 May 2018

Hepathology

Key words: BMP-2, liver fibrosis, TGF-β1 signaling [more]

Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis

Henning Ulrich, Mariusz Z Ratajczak, Gabriela Schneider, Elena Adinolfi, Elisa Orioli, Enéas G Ferrazoli, Talita Glaser, Juliana Corrêa-Velloso, Poliana C M Martins, Fernanda Coutinho, Ana P J Santos, Micheli M Pillat, Ulrich Sack, Claudiana Lameu

Frontiers in Pharmacology (Frontiers Media S.A.) Brazil, 18 May 2018

Oncology

Key words: bone marrow, bradykinin, metastasis, neuroblastoma, purinergic system [more]

Lactobacillus casei Variety rhamnosus Probiotic Preventively Attenuates 5-Fluorouracil/Oxaliplatin-Induced Intestinal Injury in a Syngeneic Colorectal Cancer Model

Ching-Wei Chang, Chia-Yuan Liu, Hung-Chang Lee, Yen-Hua Huang, Li-Hui Li, Jen-Shiu Chiang Chiau, Tsang-En Wang, Cheng-Hsin Chu, Shou-Chuan Shih, Tung-Hu Tsai, Yu-Jen Chen

Frontiers in Microbiology (Frontiers Media S.A.) Taiwan, 15 May 2018

Oncology

Key words: FOLFOX, Lactobacillus, apoptosis, gut microbiota, intestinal mucositis [more]

Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice

Zheng-HuaWangZhan-ShengHu

Biomedicine & Pharmacotherapy (Elsevier) China, 14 May 2018

Oncology

Key words: Gastric cancer, Catalpol, Migration, Apoptosis and ROS, DDP [more]

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

Amelie Griveau, GiorgioS eano, Samuel J Shelton, Robert Kupp, Arman Jahangiri, Kirsten Obernier, Shanmugarajan Krishnan, Olle R Lindberg, Tracy J Yuen, An-Chi Tien, Jennifer KSabo, Nancy Wang, Ivy Chen, Jona sKloepper, Louis Larrouquere, Mitrajit Ghosh, Itay Tirosh, Emmanuelle Huillard, Arturo Alvarez-Buylla, Michael C Oldham, Anders I Persson, William A Weiss, Tracy T Batchelor, Anat Stemmer-Rachamimov, Mario LSuvà, Joanna J Phillips, Manish K Aghi, Shwetal Mehta, Rakesh K Jain, David H Rowitch

Cancer Cell (Cell Press) USA, 14 May 2018

Oncology

Key words: Olig2, Wnt, angiogenesis, astrocyte, blood-brain barrier, glioma, invasiveness, oligodendrocyte precursor, p53, vessel co-option [more]

Hematological findings in non-treated and gamma-irradiated mice deficient for MIC-1/GDF15.

M HOFER, Z HOFEROVÁ, J REMŠÍK, M NOVÁKOVÁ, J PROCHÁZKOVÁ, R FEDR, J KOHOUTEK, L DUŠEK, A HAMPL, K SOUČEK

Physiological Research (BioMed Central) Czech Republic, 10 May 2018

Hematology

Key words: GDF15 knockout mice, hematopoiesis, ionizing radiation, stress-induced cytokine [more]

DNA damage predicts prognosis and treatment response in colorectal liver metastases superior to immunogenic cell death and T cells

Johannes Laengle, Judith Stift, Agnes Bilecz, Brigitte Wolf, Andrea Beer, Balazs Hegedus, Stefan Stremitzer, Patrick Starlinger, Dietmar Tamandl, Dietmar Pils, Michael Bergmann

Theranostics (Ivyspring International Publisher) Austria, 10 May 2018

Oncology

Key words: DNA damage, calreticulin, immunogenic cell death, colorectal liver metastases [more]

Regorafenib inhibits tumor progression through suppression of ERK/NF-κB activation in hepatocellular carcinoma bearing mice

Mao-Chi Weng, Mei-Hui Wang, Jai-Jen Tsai, Yu-Cheng Kuo, Yu-Chang Liu, Fei-Ting Hsu, Hsin-Ell Wang

Bioscience Reports (Kluwer Academic Publishers) Taiwan, 05 May 2018

Oncology

Key words: Bioluminescence imaging, Regorafenib, apoptosis, hepatocellular carcinoma, nuclear factor kappaB [more]

Effects of chitosan and chitosan N-acetylcysteine solutions on conjunctival epithelial cells

N Schuerer, E Stein, A Inic-Kanada, E Ghasemian, Marijana Stojanovic, Jacqueline Montanaro, Nora Bintner, Christine Hohenadl, Robert Sachsenhofer, Talin Barisani-Asenbauera

Journal of EuCornea (Elsevier) Austria, Serbia, 02 May 2018

Ophthalmology

Key words: Chitosan Chitosan-N-acetylcysteine Uptake Conjunctival epithelial cells Drug delivery [more]

Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor‐suppressing phenotype

Hong‐Tai Tzeng Ching‐Chin Su Chih‐Peng Chang Wu‐Wei Lai Wu‐Chou Su Yi‐Ching Wang

International Journal of Cancer (Wiley) Taiwan, 01 May 2018

Oncology

Key words: Rab37, ST2, exocytosis, macrophage, tumor microenvironment [more]

Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the Akt‑GSK3β and MAPK/ERK signaling cascades

Xiaona Wang Yanyan Zhu Lili Zhu Xinhuan Chen Yanyan Xu Yafei Zhao Yingzhe Shao Feng Li Yanan Jiang Jing Lu Youtian Huang Xiaobin Chang Juan Zhang Xiang Li Kangdong Liu Mingyao Zhao Ziming Dong Jimin Zhao

Oncology Reports (Demetrios A. Spandidos Ed. and Pub.) China, 23 April 2018

Oncology

Key words: Eupatilin, human esophageal cancer, TE1 cells, Akt‑GSK3β, MAPK/ERK [more]

Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1

Aline Yen LingWanga Charles Yuen YungLoh Shyi-JouChen Huang-KaiKao Cheng-HungLin Sheng-HaoChuang Chin-MingLee Huey-KangSytwu Fu-ChanWei

Molecular Immunology (Elsevier) Taiwan, 23 April 2018

Immunology

Key words: Allograft tolerance, B lymphocyte-induced maturation protein, T cells [more]

IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury

Wei-Yu Chen, Jenq-Lin Yang, Yi-Hsiu Wu, Lung-Chih Li, Ru-Fang Li, Ya-Ting Chang, Lo-Hsin Dai, Wan-Chen Wang, Ya-Jen Chang

Experimental & Molecular Medicine (Nature) Taiwan, 20 April 2018

Nephrology

Key words: IL-33/ST2 axis, hyperplasia, renal injury, unilateral ureteral obstruction (UUO) [more]

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Stuart Horswell, Tim Chambers

CELL (Cell Press) UK, 19 April 2018

Oncology

Key words: branched evolution, cancer evolution, chromosome instability, deterministic evolution, intratumor heterogeneity, linear evolution, metastasis, punctuated evolution, renal cell cancer, tumor diversity [more]

Tumor-induced generation of splenic erythroblast-like Ter-cells promotes tumor progression

Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, Fan J, Zhou W, Qiu S, Zhang Y, Dong T, Li N, Jiang Z, Zhu H, Zhang Q, Ma Y, Zhang Q, Wang Q, Yu Y, Li N, Cao X

CELL (Cell Press) China, 19 April 2018

Oncology

Key words: Ter-119, Ter-cell, artemin, cancer immunotherapy, erythroblast-like, hepatocellular carcinoma, prognosis biomarker [more]

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Tim Chambers, Jose I Lopez, David Nicol

CELL (Cell Press) UK, 19 April 2018

Oncology

Key words: chromosome instability, cytoreductive nephrectomy, evolution of metastasis, loss of 9p, metastasectomy, metastasis, oligometastasis, renal cell cancer, solitary metastasis [more]

Conditional depletion of GSK3b protects oligodendrocytes from apoptosis and lessens demyelination in the acute cuprizone model

Bin Xing Lauren E Brink Kelly Maers Mara L Sullivan Richard J Bodnar Donna B Stolz Franca Cambi

GLIA (Wiley) USA, 18 April 2018

Neuroscience

Key words: GSK3b, cell death, glia, multiple sclerosis [more]

CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer

Teresa PRaposoabMireia SuecaComescAdeyemiIdowuaBoraAgitaJamesHassallabWakkasFadhilabRobertNicadRupertEckerdTakashiYaoeMohammadIlyas

Experimental & Molecular Medicine (Elsevier) UK, 11 April 2018

Oncology

Key words: CD10, NEP, CALLA, Colorectal cancer, Epithelial-mesenchymal transition, Metastasis [more]

Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma

Patrick J Cimino Youngmi Kim Hua-Jun Wu Jes Alexander, Hans-Georg Wirsching Frank Szulzewsky,1 Ken Pitter,7 Tatsuya Ozawa,1,8 Jiguang Wang,9,10,16 Julio Vazquez,11 Sonali Arora,1 Raul Rabadan Ross Levine Franziska Michor and Eric C Holland

Genes and Development (Cold Spring Harbor Laboratory Press) USA, 09 April 2018

Oncology

Key words: glioblastoma, HoxA, homeobox RCAS, chromosome 7 gain [more]

Photodynamic Effect of Methylene Blue and Low Level Laser Radiation in Head and Neck Squamous Cell Carcinoma Cell Lines

Barbara Kofler, Angela Romani, Christian Pritz, Teresa Bernadette Steinbichler, Volker Hans Schartinger, Herbert Riechelmann, Jozsef Dudas

International Journal of Molecular Sciences (MDPI) Austria, 07 April 2018

Oncology

Key words: TissueFaxs, head and neck carcinoma, methylene blue, photodynamic therapy [more]

The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivo

Takashi Maehara, Hamid Mattoo, Vinay S Mahajan, Samuel JH Murphy, Grace J Yuen, Noriko Ishiguro, Miho Ohta, Masafumi Moriyama, Takako Saeki, Hidetaka Yamamoto, Masaki Yamauchi, Joe Daccache, Tamotsu Kiyoshima, Seiji Nakamura, John H Stone, Shiv Pillai

Life Science () USA, Japan, 05 April 2018

Immunology

Key words: T follicular helper (TFH), BATF+, IgG4 class switching, Sjögren's syndrome, secondary lymphoid organs [more]

Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice

Hanna Kuk,Caroline Arnold,Andreas H Wagner,Markus Hecker,Carsten Sticht, and Thomas Korff

Frontiers in Physiology (Frontiers Media S.A.) Germany, 04 April 2018

Physiology

Key words: endothelial cells, spider veins, venous hypertension, venous remodeling, wall stress [more]

Cordyceps militaris Extract Inhibits the NF-κB pathway and Induces Apoptosis through MKK7-JNK Signaling Activation in TK-10 Human Renal Cell Carcinoma

SJ Park, HJ Jang, IH Hwang, JM Kim, E Jo, MG Lee, IS Jang, J Cheon Joo

Natural Product Communications (SAGE Journals) South Korea, 01 April 2018

Oncology

Key words: Cordyceps militaris, Apoptosis, NF-κB, MKK7, JNK, TK-10 [more]

Amentoflavone enhances the therapeutic efficacy of sorafenib by inhibiting anti-apoptotic potential and potentiating apoptosis in hepatocellular carcinoma in vivo

JJ Tsai, FT Hsu, PJ Pan, CW Chen, YC Kuo

Anticancer Research (International Institute of Anticancer Research) Taiwan, 01 April 2018

Oncology

Key words: Amentoflavone sorafenib hepatocellular carcinoma ERK AKT apoptosis [more]

Periostin antisense oligonucleotide suppresses bleomycin‐induced formation of a lung premetastatic niche for melanoma

Takashi Semba Eiji Sugihara Nagisa Kamoshita Sayaka Ueno Keitaro Fukuda Masafumi Yoshino Kazumasa Takao Kazunori Yoshikawa Kenji Izuhara Yoshimi Arima Makoto Suzuki Hideyuki Saya

Cancer Science (Wiley) Japan, 31 March 2018

Oncology

Key words: antisense oligonucleotide, lung fibrosis, melanoma, periostin, premetastatic niche [more]

MRI‐guided interventional natural killer cell delivery for liver tumor treatment

Zhanliang Su, Xifu Wang, Linfeng Zheng, Tianchu Lyu, Matteo Figini, Bin Wang, Daniel Procissi, Junjie Shangguan, Chong Sun, Liang Pan, Lei Qin, Bin Zhang, Yury Velichko, Riad Salem, Vahid Yaghmai, Andrew C Larson, Zhuoli Zhang

Cancer Medicine (Wiley) USA, 30 March 2018

Oncology

Key words: Adoptive transfer immunotherapy, hepatocellular carcinoma, interventional oncology, magnetic resonance imaging, natural killer cell [more]

Collagen morphology influences macrophage shape and marker expression in vitro

Gwenda F Vasse, Philipp T Kühn, Qihui Zhou, Shardul A Bhusari, Catharina Reker-Smit, Barbro N Melgert, Patrick van Rijn

Journal of Immunology and Regenerative Medicine (Elsevier) The Netherlands, 30 March 2018

Immunology

Key words: Extracellular matrix, Collagen type I, Pulmonary fibrosis, Ym1, CD206, Migration [more]

Olaparib is effective in combination with, and as maintenance therapy after, first‐line endocrine therapy in prostate cancer cells

Gertrud E Feiersinger1，Kristina Trattnig1, Peter D Leitner, Fabian Guggenberger,Alexander Oberhuber, Sarah Peer, Martin Hermann, Ira Skvortsova, Jana Vrbkova, Jan Bouchal, Zoran Culig and Fred eric R Santer

Molecular Oncology (Wiley) Austria, 15 March 2018

Oncology

Key words: PARP inhibition, combination therapy, endocrine therapy, maintenance therapy, olaparib, prostate cancer [more]

Loss of Neuroglobin Expression Alters Cdkn1a/Cdk6-Expression Resulting in Increased Proliferation of Neural Stem Cells

Evi Luyckx, Wendy Van Leuven, Daniel Andre, Alessandra Quarta, Kristien Reekmans, Erik Fransen, Luc Moens, Thomas Hankeln, Peter Ponsaerts, and Sylvia Dewilde

Stem Cells and Development (Mary Ann Liebert Inc.) Belgium, Germany, 15 March 2018

Stem Cell Research

Key words: neuroglobin – cell cycle – transcriptomics – neural stem cells [more]

Effects of iota-carrageenan on ocular Chlamydia trachomatis infection in vitro and in vivo

Aleksandra Inic-Kanada, Elisabeth Stein, Marijana Stojanovic, Nadine Schuerer, Ehsan Ghasemian, Ana Filipovic, Emilija Marinkovic, Dejana Kosanovic, Talin Barisani-Asenbauer

Journal of Applied Phycology (Kluwer Academic Publishers) Austria, 13 March 2018

Microbiology

Key words: Carrageenan, Trachoma, Natural products, Chlamydia [more]

Prostaglandin E2 Is Required for BMP4-Induced Mesoderm Differentiation of Human Embryonic Stem Cells

Bowen Zhang,1,2,3 Lijuan He,1,2,3 Yiming Liu,1,2 Jing Zhang,1,2 Quan Zeng,1,2 Sihan Wang,1,2 Zeng Fan,1,2 Fang Fang Lin Chen Yang Lv Jiafei Xi Wen Yue Yanhua Li and Xuetao Pei

Stem Cell Reports (Cell Press) China, 13 March 2018

Stem Cell Research

Key words: prostaglandin E2, cyclooxygenase-1, BMP4, mesoderm, differentiation, human embryonic stem cells, β-catenin, [more]

Atlas of the Striatum and Globus Pallidus in the Tree Shrew: Comparison with Rat and Mouse

Rong-Jun Ni，Zhao-Huan Huang，Yu-Mian Shu，Yu Wang Tao Li， Jiang-Ning Zhou

Neuroscience Bulletin (Springer) China, 05 March 2018

Neuroscience

Key words: Striatum, Globus pallidus, Basal ganglia, Reconstruction, Rodent, Parvalbumin [more]

Novel platforms of multiplexed immunofluorescence for study of paraffin tumor tissues

Edwin Roger Parra

Journal of Cancer Treatment and Diagnosis (Sciaccess Publishers) USA, 01 March 2018

Cytometry

Key words: Multiplexed proteins identification Immunofluorescence Signal Amplification Spatial Cell Distribution Image Analysis

4:20 PM Abstract No. 350 Interferon-gamma-eluting microspheres for MRI-guided immunotherapy of liver cancer

WParkAGordonSChoXHuangKHarrisZZhangALarsonDKim

Journal of Vascular and Interventional Radiology (Elsevier) USA, 01 March 2018

Oncology

[more]

In vitro behavior of human mesenchymal stem cells on poly(N-isopropylacrylamide) based biointerfaces obtained by matrix assisted pulsed laser evaporation

Madalina Icriverzi, Laurentiu Rusen, Livia Elena Sima, Antoniu Moldovan, Simona Brajnicov, Anca Bonciu, Natalia Mihailescu, Maria Dinescu, Anisoara Cimpean, Anca Roseanu, Valentina Dinca

Applied Surface Science (Elsevier) Romania, 28 February 2018

Cell Biology

Key words: pNIPAM coatings, MAPLE, mesenchymal stem cells [more]

[18F]FEPPA: Improved Automated Radiosynthesis, Binding Affinity, and Preliminary in Vitro Evaluation in Colorectal Cancer

Neydher Berroterán-Infante, Theresa Balber, Petra Fürlinger, Michael Bergmann, Rupert Lanzenberger, Marcus Hacker, Markus Mitterhauser and Wolfgang Wadsak

ACS Medicinal Chemistry Letters (ACS Publications) Austria, 21 February 2018

Radiotherapy

Key words: Affinity, autoradiography, colorectal cancer, FEPPA, radiosynthesis, TSPO [more]

CXCL5 facilitates melanoma cell-neutrophil interaction and lymph node metastasis

Ana Soler Cardona, Agnes Forsthuber, Katharina Lipp, Stefanie Ebersbergr, Magdalena Heinz, Klaudia Schossleitner, Elisabeth Buchberger, Mario Gröger, Peter Petzelbauer, Christoph Hoeller, Erwin Wagner, Robert Loewe

Journal of Investigative Dermatology (Elsevier) Austria, 21 February 2018

Dermatology

Key words: CXCL5, melanoma cells, chemokine mRNA expression [more]

Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain

Yi-Chao Lee, Ying-Chao Chang, Chia-Ching Wu,Chao-Ching Huang

Molecular Neurobiology (Springer) Taiwan, 19 February 2018

Neuroscience

Key words: Neonatal brain injury, neurovascular protection, hypoxia-preconditioned, human umbilical vein endothelial cells, hypoxia-inducible factor 1-alpha [more]

Inflammatory Monocytes Drive Influenza A Virus–Mediated Lung Injury in Juvenile Mice

Bria M Coates, Kelly L Staricha, Clarissa M Koch, Yuan Cheng, Dale K Shumaker, G R Scott Budinger, Harris Perlman, Alexander V Misharin and Karen M Ridge

The Journal of Immunology (American Association of Immunologists) USA, 14 February 2018

Immunology

Key words: Influenza A virus (IAV), NLRP3 inflammasome, cytokines, monocytes [more]

Preclinical In Vitro and In Vivo Evaluation of [18F]FE@SUPPY for Cancer PET Imaging: Limitations of a Xenograft Model for Colorectal Cancer

T Balber, JSinger, N Berroterán-Infante, M Dumanic, L Fetty, J Fazekas-Singer, C Vraka, L Nics, M Bergmann, K Pallitsch, H Spreitzer, W Wadsak, M Hacker, E Jensen-Jarolim, H Viernstein, and M Mitterhauser,

Contrast Media and Molecular Imaging (Wiley) Austria, 13 February 2018

Oncology

Key words: [18F]FE@SUPPY, Cancer PET Imaging, Colorectal Cancer [more]

Calcium signaling mediates five types of cell morphological changes to form neural rosettes

Hana Hříbková, Marta Grabiec, Dobromila Klemová, Iva Slaninová, Yuh-Man Sun

Journal of Cell Science (The Company of Biologists) Czech Republic, 12 February 2018

Neuroscience

Key words: Embryonic stem cells, neural stem cell niche, neural rosette formation, calcium, neurogenesis, adherens junctions, cytoskeleton proteins [more]

Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers

Junko Ohtsuka, Hiroko Oshima, Issei Ezawa, Ryo Abe, Masanobu Oshima and Rieko Ohki

Scientific Reports (Nature) Japan, 02 February 2018

Oncology

Key words: Gastric cancer, p53 mutations, tumour-suppressor proteins [more]

Angiogenin Attenuates Scar Formation in Burn Patients by Reducing Fibroblast Proliferation and Transforming Growth Factor β1 Secretion

SC Pan, CH Lee, CL Chen, WY Fang, LW Wu

Annals of Plastic Surgery (LWW Journals) Taiwan, 01 February 2018

Regenerative Medicine

Key words: angiogenin, fibroblast, scar, Smad2, transforming growth factor β1 [more]

Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of “luminal” muscle-invasive bladder cancers

Simon C Baker, Volker M Arlt, Radek Indra, Madeleine Joel, Marie Stiborová, Ian Eardley, Niaz Ahmad, Wolfgang Otto, Maximilian Burger, Peter Rubenwolf, David H Phillips, Jennifer Southgate

Molecular Carcinogenesis (Wiley) UK, 01 February 2018

Oncology

Key words: Urothelium, carcinogens, normal human urothelial (NHU) cells, EROD activity [more]

Grey matter OPCs are less mature and less sensitive to IFNγ than white matter OPCs: consequences for remyelination

Dennis H Lentferink, Jacomien M Jongsma, Inge Werkman and Wia Baron

Scientific Reports (Nature) The Netherlands, 01 February 2018

Neuroscience

Key words: Multiple sclerosis (MS), central nervous system, oligodendrocyte progenitor cells (OPCs) [more]

Assessing the selective therapeutic efficacy of superparamagnetic erlotinib nanoparticles in lung cancer by using quantitative magnetic resonance imaging and a nuclear factor kappa-B reporter gene system

Fei-Ting Hsu, Hua-Shan Liu, Ahmed Atef Ahmed Ali, Ping-Huei Tsai, Yu-Chieh Kao, Chia-Feng Lu, Hsu-Shan Huang Cheng-Yu Chen

Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier) Taiwan, 31 January 2018

Nanomedicine

Key words: Erlotinib, superparamagnetic iron oxide, magnetic resonance imaging, nuclear factor-κBNon-small-cell lung cancer [more]

Expression of cystatin C in the female reproductive tract and its effect on human sperm capacitation

Robert Kuo-Kuang Lee, Huan-Chin Tseng, Yuh-Ming Hwu, Chi-Chen Fan, Ming-Huei Lin, Jhih-Jie Yu, Ling-Yu Yeh and Sheng-Hsiang Li

Reproductive Biology and Endocrinology (Springer) Taiwan, 30 January 2018

Reproductive Medicine

Key words: Cystatin C (CST3), seminal plasma, sperm protein tyrosine phosphorylation [more]

SPK1-transfected UCMSC has better therapeutic activity than UCMSC in the treatment of experimental autoimmune encephalomyelitis model of Multiple sclerosis

Yun-Liang Wang, Peng Xue, Chun-Yang Xu, Zhen Wang, Xin-Shan Liu, Lin-Lin Hua, Hong-Ying Bai, Zhi-Lei Zeng, Hai-Feng Duan and Jin-Feng Li

Scientific Reports (Nature) China, 29 January 2018

Neuroscience

Key words: Multiple Sclerosis (MS), central nervous system, permanent neurological damage, cytokine [more]

AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling

Jian Chen, Yi-feng Yang, Yu Yang, Peng Zou, Jun Chen, Yongquan He, Sai-lan Shui, Yan-ru Cui, Ru Bai, Ya-jun Liang, Yunwen Hu, Biao Jiang, Lu Lu, Xiaoyan Zhang, Jia Liu and Jianqing Xu

Nature Microbiology (Nature) China, 29 January 2018

Microbiology

Key words: Zika virus (ZIKV), neonatal microcephaly, Guillain–Barré syndrome, AXL [more]

Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis

J B Wechsler, A Szabo, C L Hsu, R A Krier-Burris, H A Schroeder, M Y Wang, R G Carter, T E Velez, L M Aguiniga, J B Brown, M L Miller, B K Wershil, T A Barrett and P J Bryce

Mucosal Immunology (Nature) USA, 24 January 2018

Immunology

[more]

Injectable hydroxyphenyl derivative of hyaluronic acid hydrogel modified with RGD as scaffold for spinal cord injury repair

Kristyna Zaviskova, Dmitry Tukmachev, Jana Dubisova, Irena Vackova, Ales Hejcl, Julie Bystronova, Martin Pravda, Ivana Scigalkova, Romana Sulakova, Vladimir Velebny, Lucie Wolfova, Sarka Kubinova

Journal of Biomedical Materials Research (Wiley) Czech Republic, 23 January 2018

Regenerative Medicine

Key words: Hydrogel, spinal cord injury (SCI), hydroxyphenyl derivative of hyaluronic acid (HA-PH) [more]

CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells

Santosh Kumar Singh, Manoj K Mishra, Isam-Eldin A Eltoum, Sejong Bae, James W Lillard Jr and Rajesh Singh

Scientific Reports (Nature) USA, 22 January 2018

Oncology

Key words: Pancreatic cancer (PC), CCR5, CCL5, F-actin polymerization [more]

Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet

Fanny Herisson, Iris Zhou, Jerome Mawet, E Du, Arnavaz H Barfejani, Tao Qin, Marilyn J Cipolla, Philip Z Sun, Natalia S Rost, Cenk Ayata

Journal of Cerebral Blood Flow and Metabolism (SAGE Journals) USA, 19 January 2018

Oncology

Key words: Animal models, hypertension, posterior cerebral reversible encephalopathy, cerebral blood flow, white matter [more]

Simvastatin induces G1 arrest by up-regulating GSK3β and down-regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells

Ming-Jenn Chen, An-Ching Cheng, Ming-Fen Lee, Yi-Chiang Hsu

Journal of Cellular Physiology (Wiley) Taiwan, 15 January 2018

Oncology

Key words: Simvastatin (SIM), colorectal cancer (CRC), CDK4/cyclin D1 [more]

Canine macrophages can like human macrophages be in vitro activated toward the M2a subtype relevant in allergy

Ina Herrmanna, Jelena Gotovina, Judit Fazekas-Singera, Michael BFischer, Karin Hufnagl, Rodolfo Bianchini, Erika Jensen-Jarolima

Developmental & Comparative Immunology (Elsevier) Austria, 10 January 2018

Immunology

Key words: Allergy, canine, comparative, DH82M1 macrophage, M2a macrophage, polarization [more]

Formation of nanotubular TiO2 structures with varied surface characteristics for biomaterial applications

Robinson Aguirre, Mónica Echeverry-Rendón, David Quintero, Juan G Castaño, Martin C Harmsen, Sara Robledo, Félix Echeverría E

Journal of Biomedical Materials Research (Wiley) Colombia, 09 January 2018

Biological Materials

Key words: Anodization, titanium, nanotubular TiO2, counterion [more]

Physical-chemical characterization and biological assessment of simple and lithium-doped biological-derived hydroxyapatite thin films for a new generation of metallic implants

ACPopescu, PEFlorian, GEStan, GPopescu-Pelin, IZgura, MEnculescu, FNOktard, RTrusca, LESima, ARoseanu, LDuta

Applied Surface Science (Elsevier) Romania, Turkey, 06 January 2018

Regenerative Medicine

Key words: Biological-derived hydroxyapatite, Lithium doping, Pulsed Laser Deposition, Sustainable resources, In vitro assessment [more]

Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?

Jiri Ruzicka, Lucia Machova Urdzikova, Barbora Svobodova, Anubhav G Amin, Kristyna Karova, Jana Dubisova, Kristyna Zaviskova, Sarka Kubinova, Meic Schmidt, Meena Jhanwar-Uniyal, and Pavla Jendelova

Neural Regeneration Research (Publishing House of Neural Regeneration Research) Czech Republic, USA, 01 January 2018

Regenerative Medicine

Key words: spinal cord injury,  epigallocatechin gallate,  curcumin,  inflammatory response,  neural regeneration [more]

Zinc finger protein 143 expression is closely related to tumor malignancy via regulating cell motility in breast cancer

AR Paek, JY Mun, KM Hong, J Lee, DW Hong, HJ You

BMB Reports (NCBI) South Korea, 31 December 2017

Oncology

Key words: Invasive ductal carcinoma, Metastasis, Motility, ZNF143 [more]

AKT3 drives adenoid cystic carcinoma development in salivary glands

Katalin Zboray, Julian Mohrherr, Patricia Stiedl, Klemens Pranz, Laura Wandruszka, Beatrice Grabner, Robert Eferl, Richard Moriggl, Dagmar Stoiber, Kazuhito Sakamoto, Kay-Uwe Wagner, Helmut Popper, Emilio Casanova, Herwig P Moll

Cancer Medicine (Wiley) Austria, 28 December 2017

Oncology

Key words: AKT3, adenoid cystic carcinoma, MMTV-tTA mouse model, oncogene addiction, salivary gland cancer [more]

A benchmark for comparing precision medicine methods in thyroid cancer diagnosis using tissue microarrays

Ching-Wei Wang, Yu-Ching Lee, Evelyne Calista, Fan Zhou, Hongtu Zhu, Ryohei Suzuki, Daisuke Komura, Shumpei Ishikawa, Shih-Ping Cheng

Bioinformatics (Oxford University Press) Taiwan, USA, Japan, 23 December 2017

Biological Methods

Key words: precision medicine, cancer diagnosis, tissue microarray [more]

Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways

Lu Ji, Bing Zhong, Xi Jiang, Fei Mao, Gang Liu, Bin Song, Cheng-Yuan Wang, Yong Jiao, Jiang-Ping Wang, Zhi-Bin Xu, Xing Li, and Bo Zhan

Oncotarget (Impact Journals) China, 22 December 2017

Oncology

Key words: human bladder cancer, Actein (ACT), autophagy and apoptosis, ROS and JNK, AKT [more]

Recurrent infection progressively disables host protection against intestinal inflammation

WH Yang, DM Heithoff, PV Aziz, M Sperandio, V Nizet, MJ Mahan, JD Marth

Science (American Association for the Advancement of Science) USA, Germany, 22 December 2017

Immunology

Key words: Recurrent infection, host protection, intestinal inflammation [more]

CD151, A Novel Host Factor of Nuclear Export Signaling in Influenza Virus Infection

Yongkang Qiao, Yan Ya, Kai Sen Tan, Sheryl SL Tan, Ju Ee Seet, Thiruma Valavan Arumugam, Vincent TK Chow, De Yun Wang

Journal of Allergy and Clinical Immunology (Elsevier) Singapore, 21 December 2017

Immunology

Key words: Influenza A virus (IAV), CD151, nuclear export, host innate immunity, inflammasome, IAV severity [more]

Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy

Louisa Kühne, Bettina Jung, Helen Poth, Antonia Schuster, Simone Wurm, Petra Ruemmele, Bernhard Banas, Tobias Bergler

BMC Immunology (BioMed Central) Germany, 19 December 2017

Immunology

Key words: Donor specific antibodies, humoral rejection, renal transplantation, non-adherence, leukocyte infiltration, BAFF [more]

Mitochondrial ROS activates ERK/autophagy pathway as a protected mechanism against deoxypodophyllotoxin-induced apoptosis

Sang-Hun Kim, Kwang-Youn Kim, Sul-Gi Park, Sun-Nyoung Yu, Young-Wook Kim, Hyo-Won Nam, Hyun-Hee An, Young-Woo Kim, and Soon-Cheol Ahn

Oncotarget (Impact Journals) South Korea, USA, 19 December 2017

Oncology

Key words: Deoxypodophyllotoxin, apoptosis, autophagy, mitochondrial ROS, ERK [more]

Magnolol inhibits venous remodeling in mice

Hanna Kuk, Caroline Arnold, Ralph Meyer, Markus Hecker and Thomas Korff

Scientific Reports (Nature) Germany, 19 December 2017

Cardiology

Key words: Magnolol, venous vasculature, endothelial cells, varicose/spider veins, peripheral vascular disease [more]

Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release

Raluca Ianchis, Claudia M Ninciuleanu, Ioana C Gifu, Elvira Alexandrescu, Raluca Somoghi, Augusta R Gabor, Silviu Preda, Cristina L Nistor, Sabina Nitu, Cristian Petcu, Madalina Icriverzi, Paula E Florian and Anca M Roseanu

Nanomaterials (MDPI) Romania, 13 December 2017

Nanomedicine

Key words: hydrogel, clay, nanocomposites, biocompatibility [more]

18F-FDG PET Biomarkers Help Detect Early Metabolic Response to Irreversible Electroporation and Predict Therapeutic Outcomes in a Rat Liver Tumor Model

Xifu Wang, Zhanliang Su, Tianchu Lyu, Matteo Figini, Daniel Procissi, Junjie Shangguan, Chong Sun, Bin Wang, Na Shang, Shanzhi Gu, Quanhong Ma, Andrew C Gordon, Kai Lin, Jian Wang, Robert J Lewandowski, Riad Salem, Vahid Yaghmai, Andrew C Larson, Zhuoli Zhang

Radiology (Radiological Society of North America) USA, China, 12 December 2017

Radiotherapy, Oncology

Key words: 18F-FDG PET, Biomarkers, Metabolic Response, Irreversible Electroporation, Liver Tumor [more]

Comparison of MOLLI, shMOLLLI, and SASHA in discrimination between health and disease and relationship with histologically derived collagen volume fraction

Nicholas Child, Gonca Suna, Darius Dabir, May-Lin Yap, Toby Rogers, Misha Kathirgamanathan, Eduardo Arroyo-Ucar, Rocio Hinojar, Islam Mahmoud, Christopher Young, Olaf Wendler, Manuel Mayr, Banher Sandhu, Geraint Morton, Marion Muhly-Reinholz, Stefanie Dimmeler, Eike Nagel, Valentina O Puntmann

European Heart Journal (Oxford University Press) UK, Germany, Spain, 11 December 2017

Cardiology

Key words: T1 mapping, MOLLI, shMOLLI, SASHA, collagen, aortic valve stenosis, myocardium, troponin, myocardial fibrosis, collagen, respiratory care units, therapeutic equivalency, transverse spin relaxation time [more]

INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis

Shin-Ai Lee, Han-Sae Lee, Shin-Kyoung Hur, Sang Won Kang, Goo Taeg Oh, Daekee Lee, and Jongbum Kwon

Oncotarget (Impact Journals) South Korea, 06 December 2017

Oncology

Key words: INO80 chromatin remodeling complex, colon cancer, APC Min mouse model, replication stress, apoptosis [more]

Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer

An Ning Cheng, Chi-Chen Fan, Yu-Kang Lo, Cheng-Liang Kuo, Hui-Chun Wang, I-Hsin Lien, Shu-Yu Lin, Chung-Hsing Chen, Shih Sheng Jiang, I-Shou Chang, Hsueh-Fen Juan, Ping-Chiang Lyu and Alan Yueh-Luen Lee

Scientific Reports (Nature) Taiwan, 05 December 2017

Oncology

Key words: Phosphorylation, cancer therapeutic resistance, Cdc7-Dbf4 kinase, stress [more]

Nocturnal resveratrol administration inhibits chemically induced breast cancer formation in rats

T KISKOVA, V DEMECKOVA, Z JENDZELOVSKA, M KIKTAVA, K VENGLOVSKA, M BOHMDORFER, W JAGER, T THALHAMMER

JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (Polish Physiological Society) Slovakia, Austria, 01 December 2017

Oncology

Key words: resveratrol, circadian rhythm, carcinogenesis, breast cancer, immunity, reactive oxygen species [more]

IgE autoreactivity in bullous pemphigoid: eosinophils and mast cells as major targets of pathogenic immune reactants

PC Freire, CH Muñoz, G Stingl

British Journal of Dermatology (Wiley) Austria, 28 November 2017

Dermatology

Key words: Bullous pemphigoid (BP), urticarial eruptions, IgG, IgE [more]

Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs)

Simona Grasso, Ariane Neumann, Irene MLang, Michael Etscheid, Marenvon Köckritz-Blickwede, Sandip MKanse

Thrombosis Research (Elsevier) Austria, Germany, Norway, 21 November 2017

Cell Biology

Key words: NETs, FSAP, thrombosis, inflammation [more]

Analysis of anti-TNF-induced skin lesions reveals strong Th1 activation with some distinct immunological characteristics

E Stoffel, H Maier, E Riedl, M-C Brüggen, B Reininger, M Schaschinger, C Bangert, E Guenova, G Stingl, PM Brunner

British Journal of Dermatology (Wiley) Austria, USA, 16 November 2017

Dermatology

Key words: Psoriasiform, eczematous eruptions, anti-TNF-α therapy, IFN-γ [more]

Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making

Alexander Friedman, Daigo Homma, Bernard Bloem, Leif GGibb, Ken-ichi Amemori, Dan Hu, Sebastien Delcasso, Timothy FTruong, Joyce Yang, Adam SHood, Katrina AMikofalvy, Dirk WBeck, Norah Nguyen, Erik DNelson, Sebastian EToro Arana, Ruth HVorder Bruegge, Ki AGoosens, Ann MGraybiel

CELL (Cell Press) USA, 16 November 2017

Neuroscience

Key words: Striatum, basal ganglia, cost-benefit, prefrontal cortex, optogenetics, prelimbic cortex, parvalbumin-positive interneurons, fast-spiking interneuron, sexcitation-inhibition balance [more]

Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation

Amanda R Noble, Norman J Maitland, Daniel M Berney and Martin G Rumsby

British Journal of Cancer (Nature) UK, 14 November 2017

Oncology

Key words: Phospholipases, mTOR, PKB/Akt, prostate cancer (PCa), benign prostatic hyperplasia (BPH) [more]

Controlled release of liposome-encapsulated temozolomide for brain tumour treatment by convection-enhanced delivery

Chung-Yin Lin, Rui-Jin Li, Chiung-Yin Huang, Kuo-Chen Wei

Journal of Drug Targeting (Taylor and Francis) Taiwan, 14 November 2017

Oncology

Key words: Convention-enhanced delivery, drug delivery, liposome, temozolomide, brain tumour [more]

Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways

Daniel L Bourque, Taufiqur Rahman Bhuiyan, Diane P Genereux, Rasheduzzaman Rashu, Crystal N Ellis, Fahima Chowdhury, Ashraful I Khan, Nur Haq Alam, Anik Paul Lazina Hossain, Leslie M Mayo-Smith, Richelle C Charles, Ana A Weil, Regina C LaRocque, Stephen B Calderwood, Edward T Ryan, Elinor K Karlsson, Firdausi Qadri and Jason B Harris

Infection and Immunity (American Society for Microbiology) USA, 13 November 2017

Immunology

Key words: Vibrio cholerae infection, cholera, Caco-2 or THP-1 cells [more]

Digital image analysis in breast pathology—from image processing techniques to artificial intelligence

Stephanie Robertson, Hossein Azizpour, Kevin Smith, Johan Hartman

Translational Research (Elsevier) Sweden, 07 November 2017

Oncology

Key words: Breast cancer, histopathology, biomarker, artificial intelligence (AI) [more]

Cyclin D1 promoter -56 and -54 bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen's disease

Wei-Ting Liao, Huey-Ling You, Chee-Yin Chai, Chih-Hung Lee, Cheng-Che E Lang, Shun-Jen Chang, Chu-Ling Yui, Hsin-Su Yu

Journal of Dermatological Science (Elsevier) Taiwan, 31 October 2017

Oncology

Key words: Arsenic-induced Bowen's disease, cyclin D1 un-methylation, aneuploidy, predictor, invasive progression [more]

HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues

Talha Qaiser,Abhik Mukherjee, Chaitanya Reddy PB, Sai D Munugoti, Vamsi Tallam, Tomi Pitkäaho, Taina Lehtimäki, Thomas Naughton, Matt Berseth, Aníbal Pedraza, Ramakrishnan Mukundan, Matthew Smith, Abhir Bhalerao, Erik Rodner, Marcel Simon, Joachim Denzler, Chao-Hui Huang, Gloria Bueno, David Snead, Ian O Ellis, Mohammad Ilyas, Nasir Rajpoot

Histopathology (Wiley) UK, 27 October 2017

Medical Image Analysis

Key words: Human epidermal growth factor receptor 2 (HER2), IHC, invasive breast cancer (BCa)

CCR7 Is Important for Mesangial Cell Physiology and Repair

Simone Wurm, Andreas Steege, Eva-Maria Rom-Jurek, Claudia R van Roeyen, Armin Kurtz, Bernhard Banas, Miriam C Banas

Journal of Histochemistry & Cytochemistry (SAGE Journals) Germany, 27 October 2017

Oncology

Key words: Homeostatic chemokine receptor CCR7, human mesangial cells, glomerulogenesis, mesangial biology [more]

Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion

Juan Zhang, Yu Zhang, Wenshuang Wu, Fang Wang, Xinyu Liu, Guanghou Shui and Chunlai Nie

Cell Death & Disease (Nature) China, 26 October 2017

Oncology

Key words: Guanylate-binding protein 2 (GBP2), interferon-γ (IFN-γ), mitochondrial fission, shRNA [more]

The Pericytic Phenotype of Adipose Tissue-derived Stromal Cells is Promoted by NOTCH2

Vincenzo Terlizzi, Matthias Kolibabka, Janette Kay Burgess, Hans Peter Hammes, Martin Conrad Harmsen

Stem Cells (Wiley) Germany, The Netherlands, 25 October 2017

Stem Cell Research

Key words: Diabetic retinopathy (DR), adipose tissue‐derived stromal cells (ASC), NOTCH2, human umbilical cord vein endothelial cells (HUVEC) [more]

The natural compound 2,3,5,4′-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway

En-Yuan Lin, Uyanga Bayarsengee, Ching-Chiung Wang, Yung-Hsiao Chiang, Chao-Wen Cheng

Environmental Toxicology (Wiley) Taiwan, 24 October 2017

Toxicology

Key words: Tetrahydroxystilbene-2-O-β-d-glucoside (THSG), Polygoni Multiflori, adriamycin (AD), quinone oxidoreductase (NQO)-1 [more]

Initial graft size and not the innate immune response limit survival of engrafted neural stem cells

Stefanie Vogel, Markus Aswendt, Melanie Nelles, Nadine Henn, Gabriele Schneider, Mathias Hoehn

Journal of Tissue Engineering and Regenerative Medicine (Wiley) Germany, 22 October 2017

Neuroscience

Key words: Transplantation of neural stem cells (NSCs), Luc2 and copGFP, bioluminescence imaging (BLI) [more]

Tumor angiogenesis and bone metastasis - Correlation in invasive breast carcinoma

Chong Sun, Jianmin Li, Bin Wang, Junjie Shangguan, Matteo Figini, Na Shang, Liang Pan, Zhuoli Zhang

Journal of Immunological Methods (Elsevier) USA, 21 October 2017

Oncology

Key words: Breast carcinoma, bone metastasis, tumor angiogenesis, pathological biomarkers [more]

The non-canonical ubiquitin activating enzyme UBA6 suppresses epithelial-mesenchymal transition of mammary epithelial cells

X Liu, L Sun, DB Gursel, C Cheng, S Huang, AW Rademaker, SA Khan, J Yin, H Kiyokawa

Oncotarget (Impact Journals) USA, 20 October 2017

Oncology

Key words: ubiquitination, breast cancer, EMT, Rho GTPase, cell cycle [more]

TDP-43 proteolysis is associated with astrocyte reactivity after traumatic brain injury in rodents

Chih-Yuan Huang, Yi-Che Lee, Ping-Chia Li, Po-Chou Liliang, Kang Lu, Kuo-Wei Wang, Li-Ching Chang, Li-Yen Shiu, Ming-Feng Chen, Yuan-Ting Sun, Hao-kuang Wang

Journal of Neuroimmunology (Elsevier) Taiwan, 20 October 2017

Neuroscience

Key words: Astrocyte, astrogliosis, traumatic brain injury, transactivation response DNA-binding protein 43 [more]

Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease

Rik Mencke, Geert Harms, Jill Moser, Matijs van Meurs, Arjan Diepstra, Henri G Leuvenink, and Jan-Luuk Hillebrands

The Journal of Clinical Investigation (American Society for Clinical Investigation) The Netherlands, 19 October 2017

Nephrology

Key words: Aging, Nephrology, Chronic kidney disease, RNA processing [more]

Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression

In-Hu Hwang, Seung Yoon Oh, Hyun-Jin Jang, Eunbi Jo, Jong Cheon Joo, Kyung-Bok Lee, Hwa-Seung Yoo, Mi Young Lee, Soo Jung Park, Ik-Soon Jang

PLoS One (PLOS) South Korea, 18 October 2017

Oncology

Key words: Cellular FLICE inhibitory protein (c-FLIP), NF-κB, apoptosis, cordycepin [more]

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J Herold, Andreas Strasser and Andreas Villunger

Nature Communications (Nature) Austria, Australia, 18 October 2017

Immunology

Key words: Tet-On/Off system, BCL2 overexpression, CRISPR/Cas9, RNA interference (RNAi) [more]

Lactobacillus gasseri attenuates allergic airway inflammation through PPARγ activation in dendritic cells

Miao-Hsi Hsieh, Ren-Long Jan, Lawrence Shih-Hsin Wu, Pei-Chi Chen, Hui-Fang Kao,Wen-Shuo Kuo, Jiu-Yao Wang

Journal of Molecular Medicine (Springer) Taiwan, 14 October 2017

Allergy Research

Key words: Allergy asthma, lactic acid bacillus, peroxisome proliferator-activated receptor gamma (PPARγ), dendritic cells [more]

GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis

Jing Qin, Arend H Sikkema, Kristine van der Bij, Jenny C de Jonge, Karin Klappe, Vera Nies, Johan W Jonker, Jan Willem Kok, Dick Hoekstra and Wia Baron

Journal of Neuroscience (SFN) The Netherlands, 11 October 2017

Neuroscience

Key words: Fibronectin, ganglioside, multiple sclerosis, oligodendrocyte, remyelination [more]

Actein induces apoptosis in leukemia cells through suppressing RhoA/ROCK1 signaling pathway

Wen-Di Zhou, Xiang Wang, Xing-Zhen Sun, Jian Hu, Rong-Rong Zhang, Ze Hong

International Journal of Oncology (Spandidos Publications) China, 10 October 2017

Oncology

Key words: Actein, apoptosis, leukemia, RhoA/ROCK1 signaling pathway [more]

Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection

Shu-Wen Wan, Pei-Wei Chen, Chin-Yu Chen, Yen-Chung Lai, Ya-Ting Chu, Chia-Yi Hung, Han Lee, Hsuan Franziska Wu, Yung-Chun Chuang, Jessica Lin, Chih-Peng Chang, Shuying Wang, Ching-Chuan Liu, Tzong-Shiann Ho, Chiou-Feng Lin, Chien-Kuo Lee, Betty A Wu-Hsieh, Robert Anderson, Trai-Ming Yeh and Yee-Shin Lin

The Journal of Immunology (American Association of Immunologists) Taiwan, 10 October 2017

Immunology

Key words: Dengue virus (DENV), dengue fever, DENV nonstructural protein 1 (NS1) [more]

Linarin sensitizes tumor necrosis factor-related apoptosis (TRAIL)-induced ligand-triggered apoptosis in human glioma cells and in xenograft nude mice

Zan-feng Xu, Xiao-ke Sun, Ying Lan, Chao Han, Yong-dong Zhang, Gang Chen

Biomedicine & Pharmacotherapy (Elsevier) China, 06 October 2017

Oncology

Key words: TRAIL, glioma, linarin (LIN), apoptosis, ROS generation [more]

PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs

Austin K Mattox, Jina Lee, William H Westra, Robert H Pierce, Ronald Ghossein, William C Faquin, Thomas J Diefenbach, Luc G Morris, Derrick T Lin, Lori J Wirth, Armida Lefranc-Torres, Eiichi Ishida, Patrick D Chakravarty, Lauren Johnson, Yang C Zeng, Huabiao Chen, Mark C Poznansky, Neil M Iyengar and Sara I Pai

Cancer Research (AACR Publications) USA, 25 September 2017

Oncology

Key words: Oral tongue squamous cell carcinoma (OTSCC), PD-1, tumor microenvironment (TME), tumor-infiltrating lymphocytes (TIL) [more]

The microRNA ame-miR-279a regulates sucrose responsiveness of forager honey bees (Apis mellifera)

Fang Liu, Tengfei Shi, Wei Yin, Xin Su, Lei Qi, Zachary YHuang, Shaowu Zhang, Linsheng Yu

Insect Biochemistry and Molecular Biology (Elsevier) USA, China, 20 September 2017

Zoology

Key words: microRNA, honey bee, proboscis extension reflex, sucrose responsiveness, division of labour [more]

Axonal components of nerves innervating the human arm

Bernhard Gesslbauer, Laura A Hruby, Aidan D Roche, Dario Farina, Roland Blumer, Oskar C Aszmann

Annals of Neurology (Wiley) Austria, 20 September 2017

Neuroscience

Key words: Nerves, sensory and motir axons, spinal cord, neurofilament [more]

Role of BDNF and neurotrophic receptors in human inner ear development

LJ Chacko, MJF Blumer, E Pechrigg, H Rask-Andersen, W Dietl, A Haim, H Fritsch, R Glueckert, J Dudas, A Schrott-Fischer

Cell and Tissue Research (Springer) Austria, Seweden, 19 September 2017

Developmental Biology

Key words: Inner ear, Human, BDNF, Neurotrophin receptors, In situ hybridization [more]