Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 401 - 410 of 3476
401
Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway

R Wang, X Zhang, H Ye, X Yang, Y Zhao, L Wu, H Liu, Y Wen, Y Wang, M Yu, C Ma, L Wang

Cardiovascular Diabetology (Springer) China , 02 November 2024

Cardiology

Key words: Diabetic cardiomyopathy, Ferroptosis, FGF21, Ferritin, ATF4, Type 2 diabetes mellitus

Organism: Mouse

Tissue: Heart

Pathological State: Diabetes

402
Lycium barbarum polysaccharide alleviates ferroptosis in Sertoli cells through NRF2/SLC7A11/GPX4 pathway and ameliorates DEHP-induced male reproductive damage in mice

H Yang, L Ding, B Xu, Z Zhang, W Dai, T He, L Liu, X Du, X Fu

International Journal of Biological Macromolecules (Elsevier) China , 02 November 2024

Reproductive Medicine

Key words: Di-(2-ethylhexyl)phthalate, Lycium Barbarum polysaccharide, Sertoli cells, Ferroptosis, NRF2/SLC7A11/GPX4 pathway

Organism: Mouse

Tissue: Testis

Pathological State: Ferroptosis

403
Mechanism of central analgesia in rats with myofascial pain syndrome by intervention of “trigger points” with stagnant moving needles

L Zhao, Y Chen, Y Wang, Z Li, Q Zhang, B Gou

Chinese Journal of Tissue Engineering Research (CJTER) China , 02 November 2024

Pharmacology

Key words: myofascial pain syndrome, myofascial trigger points, stagnant moving needle, central analgesia, brain-derived neurotrophic factor, periaqueductal gray

Organism: Rat

Tissue: Brain

404
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway

Q Geng, W Wu, M Yang, F Gu, W Cai, Y Qin, L Wie, H Wang, N Li,

Heliyon (Cell) China , 01 November 2024

Osteology

Key words: Guilu Erxian glue, Chondrocyte, Apoptosis, Knee osteoarthritis, ATF6/GRP78/CHOP signaling pathway

Organism: Rat

Pathological State: Arthritis

Cell Line: Chondrocytes

405
Rational development of fingolimod nano-embedded microparticles as nose-to-brain neuroprotective therapy for ischemic stroke

X Zhang, G Su, Z Shao, HW Chan, S Li, S Chow, CK Tsang, SF Chow

Drug Delivery and Translational Research (Springer) China , 01 November 2024

Neuroscience

Key words: Nose-to-brain drug delivery, Neuroprotection, Ischemic stroke, Fingolimod, Nanoparticles, Particle engineering, Nasal powder

Organism: Mouse

Tissue: Brain

Pathological State: Ischemia

406
Regulatory Roles of NAMPT and NAD+ Metabolism in Uterine Leiomyoma Progression: Implications for ECM Accumulation, Stemness, and Microenvironment

YF Chiang, KC Huang, TC Huang, HY Chen, M Ali, A Al-Hendy, PS Huang, SM Hsia

Redox Biology (Elsevier) Taiwan , 31 October 2024

Reproductive Medicine

Key words: Uterine leiomyoma, NAMPT, NAD, Extracellular matrix

Organism: Human

Tissue: Uterus

Pathological State: Uterine Leiomyoma

407
How the extra X chromosome impairs the development of male fetal germ cells

Y Lu, M Qin, Q He, L Hua, X Qi, M Yang, Q Guo, X Liu, Z Zhang, F Xu, L Ding, Y Wu, C Zhang, D Zhai, Q Liu, J Li, P Yuan, X Shi, X Wang, C Zhao, Y Lian, R Li, Y Wie, L Yan, P Yuan, J Qiao

Nature (Nature) China , 30 October 2024

Reproductive Medicine

Key words: Disease Model, Embryonic germ cells

Organism: Human

Tissue: Gonad

Pathological State: Klinefelter syndrome

408
Ferroptosis-related gene signature for predicting prognosis and identifying potential therapeutic drug in EGFR wild-type lung adenocarcinoma

C Zhang, Q Wu, H Yang, H Zhang, C Liu, B Yang, Q Hu

Communications Biology (Nature) China , 30 October 2024

Oncology

Key words: Molecular medicine, Non-small-cell lung cancer, Prognostic markers

Organism: Human

Tissue: Lung

Pathological State: Cancer

409
Spinal cord neural stem cells derived from human embryonic stem cells promote synapse regeneration and remyelination in spinal cord injury model rats

X Wang, X Hu, Y Xie, T Zhao, L Liu, C Liu

European Journal of Neuroscience (Wiley Online Library) China , 29 October 2024

Neuroscience

Key words: BAF45D, human spinal cord neural stem cells, MBP, spinal cord injury, synaptophysin

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

410
Abnormal outer and inner retina in a mouse model of Huntington's disease with age

D Yang, C Huang, X Guo, Y Li, J Wu, Z Zhang, S Yan, Y Xu

Frontiers in Aging Neuroscience (frontiers) China , 28 October 2024

Neuroscience

Key words: Huntington’s disease, R6/1, mutant huntingtin, retina, photoreceptor, ganglion cell, bipolar cell, optic nerve

Organism: Mouse

Tissue: Brain

Pathological State: Huntington's Diseas

Results 401 - 410 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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