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On May 3rd 2020, TissueGnostics surpassed 1,500 scientific reference publications

 Most of the 1500 research publications referencing TissueGnostics (over 50%) originated in the United States, Austria, Germany, Taiwan (China) and mainland China.

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Customer Publications (A total of 1683 papers published)

401
Amentoflavone Effectively Blocked the Tumor Progression of Glioblastoma via Suppression of ERK/NF-B Signaling Pathway

FT Hsu, IT Chiang, YC Kuo, TC Hsia, CC Lin, YC Liu, JG Chung

The American Journal of Chinese Medicine (World Scientific) Taiwan, 17 May 2019

Oncology

Key words: Amentoflavone, Glioblastoma, Anticancer, ERK, NF-κB

Organism: Mouse

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

402
Potential Effects of CXCL9 and CCL20 on Cardiac Fibrosis in Patients with Myocardial Infarction and Isoproterenol-Treated Rats

CF Lin, CJ Su, JH Liu, ST Chen, HL Huang, SL Pan

Journal of Clinical Medicine (MDPI) Taiwan, 11 May 2019

Cardiology

Key words: myocardial infarction, cardiac fibrosis, CXCL9, CCL20, isoproterenol

Organism: Rat

Tissue: Heart

Pathological State: Cardiac Fibrosis

403
In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field

PW Nagle, MJ van Goethem, M Kempers, H Kiewit, A Knopf, JA Langendijk, S Brandenburg, P van Luijk, RP Coppes

Radiotherapy and Oncology (Elsevier) The Netherlands, 11 May 2019

Oncology

Key words: Protons, MRI, Tumor, Normal tissue, Organoids

Organism: Human

Cell Line: Human embryonic kidney cells (HEK293) and human lung adenocarcinoma cells (A549)

404
Effects of Hydroxychloroquine on the Human Placenta–Findings from In Vitro Experimental Data and a Systematic Review

RE Scott, SL Greenwood, DJL Hayes, BC Baker, RL Jones, AEP Heazell

Reproductive Toxicology (Elsevier) UK, 10 May 2019

Reproductive Medicine

Key words: Hydroxychloroquine, Placenta, TLRs, TLR 7, TLR 9, Inflammation, Toxicology, Safety, Pregnancy, SLEAPS

Organism: Human

Tissue: Placenta

405
Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

Kimberly M. Cirelli, Diane G. Carnathan, Bartek Nogal, Jacob T. Martin, Oscar L. Rodriguez, Amit A. Upadhyay, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Federico Viviano, Catherine Nakao, Matthias G. Pauthner, Samantha Reiss, Christopher A. Cottrell, Melissa L. Smith, Raiza Bastidas, William Gibson, Amber N. Wolabaugh, Mariane B. Melo, Benjamin Cossette, Venkatesh Kumar, Nirav B. Patel, Talar Tokatlian, Sergey Menis, Daniel W. Kulp, Dennis R. Burton, Ben Murrell, William R. Schief, Steven E. Bosinger, Andrew B. Ward, Corey T. Watson, Guido Silvestri, Darrell J. Irvine, Shane Crotty

CELL (Cell Press) USA, Sweden, 09 May 2019

Immunology

Key words: HIV vaccine, non-human primates, rhesus macaque genome, FNA, GC- TFH, memory B cells, somatic hypermutation, affinity maturation, immune complexes

Organism: Mouse

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

406
Multimodal [18F]FDG PET/CT is a direct readout for inflammatory bone repair: a longitudinal study in TNFα transgenic mice

Silvia Hayer, Markus Zeilinger, Volker Weiss , Monika Dumanic , Markus Seibt , Birgit Niederreiter ,Tetyana Shvets , Florian Pichler ,Wolfgang Wadsak , Bruno K. Podesser, Thomas H. Helbich, Marcus Hacker, Josef S. Smolen, Kurt Redlich , Markus Mitterhauser

Journal of Bone and Mineral Research (Wiley) Austria, 07 May 2019

Osteology

Key words: µPET/CT, 18F‐FDG, 18F‐NaF, bone healing, experimental arthritis, TNF blockade

Organism: Human

Tissue: Bone, Connective Tissue

407
Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis

GR Liguori, Q Zhou, TTA Liguori, GG Barros, PT Kühn, LF Moreira, P van Rijn, MC Harmsen

Stem Cells International (Hindawi Publishing Corporation) The Netherlands, Brazil, China, 05 May 2019

Stem Cell Research

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

408
CD11b+ cells markedly express the itch cytokine interleukin‐31 in polymorphic light eruption

V Patra, J Strobl, A Gruber‐Wackernagel, P Vieyra-Garcia, G Stary, P wolf

British Journal of Dermatology (Wiley) Austria, 03 May 2019

Dermatology

Organism: Human

Tissue: Skin

409
Endoplasmic reticulum stress is involved in stress-induced hypothalamic neuronal injury in rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK pathways

S Yi, K Chen, L Zhang, W Shi, Y Zhang, S Niu, M Jia, B Cong, Y Li

Frontiers in cellular Neuroscience (Frontiers Media S.A.) China, 03 May 2019

Neuroscience

Key words: hypothalamus, stress, neuronal injury, PERK-ATF4-CHOP pathway, IRE1-ASK1-JNK pathway

Organism: Rat

Tissue: Brain

Pathological State: Stress-Induced Hypothalamic Neuronal Injury

410
Positive PD‑L1 expression is predictive for patients with advanced EGFR wild‑type non‑small cell lung cancer treated with gemcitabine and cisplatin

Y Qiu, J Jiang, M Zhang, Y Qin

Oncology Letters (Spandidos Publications) China, 02 May 2019

Oncology

Key words: programmed death ligand-1, checkpoint, immunotherapy, non-small cell lung cancer, prognosis

Organism: Human

Tissue: Lung

Pathological State: Cancer

411
Exosomal transfer of bone marrow mesenchymal stem cells-derived miR340 attenuates endometrial fibrosis

B Xiao, Y Zhu, J Huang, T Wang, F Wang, S Sun

Biology Open (The Company of Biologists) China, 01 May 2019

Stem Cell Research

Organism: Rat

Tissue: Uterus

Pathological State: Endometriosis

412
An improved method of culturing somatotropic cells from rat adenohypophysis

J Mao, Y Bao, F Mei, X Liao, F Liu, L Zhou, B Qiu, S Qi

Tissue and Cell (Elsevier) China, 30 April 2019

Biological Methods

Key words: Pericytes, Improved method, Primary culture, Somatotropic cells

Organism: Rat

Cell Line: Pericytes

413
Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

HC Lin, YH Ching, CC Huang, PC Pao, WC Chang, TJ Kao, YC Lee

Journal of Biomedical Science (Springer) Taiwan, 26 April 2019

Neuroscience

Key words: Promyelocytic leukemia zinc finger, Plzf, luxoid mice, Cortical neuron

Organism: Mouse

Tissue: Brain

414
Wound Age Estimation by Neutrophil Migration Distance.

QQ Liu, HM Guo, L Wang, HL Lu, QX Du, RF Bai, JH Sun, YY Wang

Fa yi xue za zhi (Europe PMC) China, 25 April 2019

Immunology

415
Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production

HW Liao, TH Huang, YH Chang, HH Liou, YH Chou, YM Sue, PH Hung, YT Chang, PC Ho, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan, 25 April 2019

Osteology, Nephrology

Key words: exercise, chronic kidney disease, osteoporosis, sclerostin, chronic kidney disease–mineral bone disorder

Organism: Rat

Tissue: Bone

Pathological State: Kidney Disease

416
Th2-TRMs maintain life-long allergic memory in experimental asthma in mice

B Bosnjak, S Kazemi, LM Altenburger, G Mokrovic, MM Epstein

Frontiers in Immunology (Frontiers Media S.A.) Austria, 24 April 2019

Immunology

Organism: Mouse

Tissue: Lung

Pathological State: Asthma

417
YWHAE promotes proliferation, metastasis, and chemoresistance in breast cancer cells

YF Yang, YC Lee, YY Wang, CH Wang, MF Hou, SS Yuan

Kaohsiung journal of Medical Sciences (Wiley) Taiwan, 18 April 2019

Oncology

Key words: 14‐3‐3ε, breast cancer, chemoresistance, YWHAE

Organism: Human

Tissue: Breast

Pathological State: Cancer

418
Toll‑like receptor 4 plays a tumor‑suppressive role in cutaneous squamous cell carcinoma

Erina Mikami, Mitsuhiro Kudo, Ryuji Ohashi, Kiyoko Kawahara, Yoko Kawamoto, Kiyoshi Teduka, Takenori Fujii, Taeko Kitamura, Shoko Kure, Kousuke Ishino, Takashi Sakatani, Ryuichi Wada, Hidehisa Saeki, Zenya Naito

International Journal of Oncology (Spandidos Publications) Japan, 17 April 2019

Oncology

Key words: Toll-like receptor 4, cutaneous squamous cell carcinoma, differentiation, CD44, migration, invasion, filopodia

Organism: Human

Tissue: Skin

Pathological State: Cancer

419
Functional CD3+ CD8+ PD-1-T cells accumulation and PD-L1 expression increases during tumor invasion in DCIS of the breast

S Lv, S Wang, G Qiao, X Wang, X Zhou, F Yan, Y Li, S Wang, MA Morse, A Hobeika, J Ren, HK Lyerly

Clinical Breast Cancer (Elsevier) China, USA, 16 April 2019

Oncology

Key words: DCIS, Opal technique PDl-1, PD-1, immune, microenvironment

Organism: Human

Tissue: Breast

Pathological State: Cancer

420
Low cd8+ t cell infiltration and high pd-l1 expression are associated with level of cd44+/cd133+ cancer stem cells and predict an unfavorable prognosis in pancreatic cancer

YC Hou, YJ Chao, MH Hsieh, HL Tung, HC Wang, YS Shan

Cancers (MDPI) Taiwan, 15 April 2019

Oncology

Key words: pancreatic cancer, T cells, cancer stem cells, CD8, PD-L1, CD44, CD133, immunotherapy

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

421
Metastatic Colorectal Cancer Rewrites Metabolic Program Through a Glut3-YAP-dependent Signaling Circuit

CC Kuo, HH Ling, MC Chiang, CH Chung, WY Lee, CY Chu, YC Wu, CH Chen, YW Lai, IL Tsai, CH Cheng, CW Lin

Theranostics (Ivyspring) Taiwan, 13 April 2019

Oncology

Key words: cancer metabolism, colorectal cancer, glucose transporter, metastasis, YAP

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

422
Interrelations of Sphingolipid and Lysophosphatidate Signaling With Immune System in Ovarian Cancer

Anastasia Meshcheryakova, Martin Svoboda, Markus Jaritz, Felicitas Mungenast, Martina Salzmann, Dietmar Pils, Dan Cacsire Castillo-Tong, Gudrun Hager, Andrea Wolf, Elena Ioana Braicu, Jalid Sehouli, Sandrina Lambrechts, Ignace Vergote, Sven Mahner, Peter Birner, Philip Zimmermann, David N. Brindley, Georg Heinze, Robert Zeillinger, Diana Mechtcheriakova

Computational and Structural Biotechnology Journal (Elsevier) Austria, Germany, Belgium, Switzerland, Canada, 10 April 2019

Oncology

Key words: Sphingolipid/lysophosphatidate system, On-site immune response, Patient-specific expression data sets, Integrative analysis algorithm, Patient stratification, From systems biology to systems medicine

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

423
Au Nanoparticles with Enzyme-Mimicking Activities Ornamented ZIF-8 for Highly Efficient Photodynamic Therapy

Y Ma, Y Zhu, XF Tang, L Hang, W Jiang, M Li, M Khan, YZ You, YC Wang

Biomaterials Science (Royal Society of Chemistry) China, 04 April 2019

Nanomedicine

Key words: AuNPs nanozyme, nano metal-organic frameworks, tumor hypoxia, photodynamic therapy

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

424
Associations between hepatitis etiology and immune cell infiltration in or around hepatocellular carcinoma

Yu-Yun Shao, Min-Shu Hsieh, Yun-Ting Tsai, Ying-Chun Shen, Zhong-Zhe Lin, Ann-Lii Cheng, Chih-Hung Hsu

Cancer Research (AACR) USA, 03 April 2019

Oncology, Virology

Organism: Human

Tissue: Liver

Pathological State: Cancer

425
The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats

Hsiang-Chun Lee, Yi-Lin Shiou, Shih-Jie Jhuo, Chia-Yuan Chang, Po-Len Liu, Wun-Jyun Jhuang, Zen-Kong Dai, Wei-Yu Chen, Yun-Fang Chen and An-Sheng Lee

Cardiovascular Diabetology (Springer) Taiwan, 01 April 2019

Cardiology

Key words: SGLT2 inhibitor Empagliflozin Hypertensive Heart failure Cardiac fibrosis Hemodynamics High-fat PPARα ACADM

Organism: Rat

Tissue: Heart

Pathological State: Fibrosis

426
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells

Miroslav Boudny, Jana Zemanova, Prashant Khirsariya, Marek Borsky, Jan Verner, Jana Cerna, Alexandra Oltova, Vaclav Seda, Marek Mraz, Josef Jaros, Zuzana Jaskova, Michaela Spunarova, Yvona Brychtova, Karel Soucek, Stanislav Drapela, Marie Kasparkova, Jiri Mayer, Kamil Paruch, Martin Trbusek

Haematologica (Ferrata Storti Foundation) Czech Republic, 01 April 2019

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

427
Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells

TT Huang, YW Lan, CM Chen, YF Ko, DM Ojcius, J Martel, JD Young, KY Chong

Scientific Reports (Nature) Taiwan, USA, Malaysia, 26 March 2019

Oncology

Key words: Drug development, Lung cancer

Organism: Mouse

Tissue: Lung

428
PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma

Yong Jae Shin, Jason K. Sa, Yeri Lee, Donggeon Kim, Nakho Chang, Hee Jin Cho, Miseol Son, Michael Y.T. Oh, Kayoung Shin, Jin-Ku Lee, Jiwon Park, Yoon Kyung Jo, Misuk Kim, Patrick J. Paddison, Vinay Tergaonkar, Jeongwu Lee , Do-Hyun Nam

Journal of Experimental Medicine (Rockefeller University Press) South Korea, China, USA, 21 March 2019

Oncology, Cell Biology

Key words: Solid Tumors, Neuroscience

Organism: Human

Tissue: Brain

Pathological State: Cancer

429
Designing pH-Triggered Drug Release Iron Oxide Nanocomposites for MRI Guided Photothermal-Chemoembolization Therapy of Liver Orthotopic Cancer

F Liu, X Li, Y Li, Y Qi, H Yuan, J He, W Li, M Zhou

Biomaterials Science (Royal Society of Chemistry) China, 19 March 2019

Nanomedicine

Key words: pH-Triggered Drug Release, Iron Oxide Nanocomposites, MRI, Photothermal-Chemoembolization Therapy, Liver Orthotopic Cancer

Organism: Rat

Tissue: Liver

Pathological State: Cancer

430
γδT cells suppress liver fibrosis via strong cytolysis and enhanced NK cell-mediated cytotoxicity against hepatic stellate cells

M Liu, Y Hu, Y Yuan, Z Tian, C Zhang

Frontiers in Immunology (Frontiers Media S.A.) China, Germany, Belgium, USA, 15 March 2019

Immunology

Key words: fibrosis, γδT cell, NKp46, cytotoxicity, γδT1, γδT17, CD137, cell crosstalk

Organism: Mouse

Tissue: Liver

Pathological State: Fibrosis

431
Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo

YH Hsu, HC Chuang, YH Lee, YF Lin, YJ Chen, TC Hsiao, MY Wu, HW Chiu

Free Radical Biology and Medicine (Elsevier) Taiwan, 14 March 2019

Toxicology

Key words: Nephrotoxicity, Autophagy, Apoptosis, Endoplasmic reticulum stress

Organism: Rat

Tissue: Kidney

432
ErbB3 Ligand Heregulin1 Is a Major Mitogenic Factor for Uncontrolled Lung Cancer Cell Proliferation

S Ma, S Jia, Y Ren, B Cao, X Zha, J He, C Chen

Neoplasia (Elsevier) China, 02 March 2019

Oncology

Key words: ErbB3 , Heregulin1, Lung Cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

433
Sulfasalazine could modulate the CD44v9‐xCT system and enhance cisplatin‐induced cytotoxic effects in metastatic bladder cancer

Koichiro Ogihara, Eiji Kikuchi, Shogo Okazaki, Masayuki Hagiwara,1 Toshikazu Takeda, Kazuhiro Matsumoto, Takeo Kosaka, Shuji Mikami, Hideyuki Saya, and Mototsugu Oya

Cancer Science (NCBI) Japan, 01 March 2019

Oncology

Key words: bladder cancer, CD44v9, cisplatin, metastasis, sulfasalazine

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

434
Expression of the neonatal Fc-receptor in placental-fetal endothelium and in cells of the placental immune system

T Kiskova, Y Mytsko, M Schepelmann, H Helmer, R Fuchs, M Heidi, C Wadsack, I Ellinger

Placenta (Elsevier) Austria, 28 February 2019

Reproductive Medicine

Key words: Human placenta, FcRn, syncytiotrophoblast, placental-fetal endothelial cells, placental macrophages, IgG transport

Organism: Human

Tissue: Placenta

435
High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2

S Khanal, DA Galloway

PLoS Pathogens (PLOS) USA, 28 February 2019

Virology

Key words: Immunoblotting, Oncogenes, DNA repair, Phosphorylation, Human papillomavirus, HPV-16, Cell signaling, Small interfering RNAs

Organism: Human

Pathological State: Virus Infection

Cell Line: Primary human foreskin keratinocytes (HFKs)

436
Metabolic cross-talk between human bronchial epithelial cells and internalized Staphylococcus aureus as a driver for infection

Laura M. Palma Medina, Ann-Kristin Becker, Stephan Michalik, Harita Yedavally, Elisa J.M. Raineri, Petra Hildebrandt, Manuela Gesell Salazar, Kristin Surmann, Henrike Pförtner, Solomon A. Mekonnen, Anna Salvati, Lars Kaderali, Jan Maarten van Dijl and Uwe Völker

Molecular and Cellular Proteomics (American Society for Biochemistry and Molecular Biology) Germany, The Netherlands,, 26 February 2019

Immunology

Key words: Staphylococcus aureus, in vivo proteomics, population heterogeneity, persister, bronchial epithelial cells, Apoptosis*, Autophagy Bacteria, Energy metabolism, Host-Pathogen Interaction, Infectious disease

Organism: Human

Pathological State: Bacterial Infection

Cell Line: Bronchial epithelial cells

437
Ligase 3–mediated end-joining maintains genome stability of human embryonic stem cells

Aneta Kohutova, Jan Raška, Miriama Kruta, Monika Seneklova, Tomas Barta, Petr Fojtik, Tereza Jurakova, Christi A. Walter, Ales Hampl, Petr Dvorak, and Vladimir Rotrekl

The FASEB Journal (FASEB) Czech Republic, USA, 26 February 2019

Stem Cell Research

Key words: base excision repair, PARP1, 53BP1, pluripotent stem cells, alternative DNA end-joining

Organism: Human

Cell Line: Human embryonic stem cells

438
Higher CXCL16 exodomain is associated with aggressive ovarian cancer and promotes the disease by CXCR6 activation and MMP modulation

H Mir, G Kaur, N Kapur, S Bae, JW Lillard, S Singh

Scientific Reports (Nature) USA, 21 February 2019

Oncology

Key words: Cancer, Ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

439
State-of-the-Art of Profiling Immune Contexture in the Era of Multiplexed Staining and Digital Analysis to Study Paraffin Tumor Tissues

ER Parra, A Francisco-Cruz, II Wistuba

Cancers (MDPI) USA, 20 February 2019

Medical Image Analysis

Key words: immune profiling, cancer tissues, multiplexed methodologies, image analysis, spatial analysis

440
Long noncoding RNA AOC4P regulates tumor cell proliferation and invasion by epithelial–mesenchymal transition in gastric cancer

K Zhang, C Lu, X Huang, J Cui, J Li, Y Gao, W Liang, Y Liu, Y Sun, H Liu, B Wei, L Chen

Therapeutic Advances In Gastroenterology (SAGE Journals) China, 19 February 2019

Oncology

Key words: AOC4P, long noncoding RNAs, metastasis, prognosis, stomach neoplasm

Organism: Human

Tissue: Stomach

Pathological State: Cancer

441
B-type natriuretic peptide enhances fibrotic effects via matrix metalloproteinase-2 expression in the mouse atrium in vivo and in human atrial myofibroblasts in vitro

YT Tsai, FY Lin, CS Lin, SH Loh, CY Li, CY Lin, YW Lin, CS Tsai

Translational Research (Elsevier) Taiwan, 19 February 2019

Cardiology

Key words: B-type natriuretic peptide, atrial fibrillation, matrix metalloproteinase

Organism: Mouse

Tissue: Heart

442
SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes

I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai and Yi-Ching Wang

Journal of Biological Methods (Springer) Taiwan, 18 February 2019

Oncology

Key words: SOX17, Transcription regulation, Resistance, DNA repair, Concurrent chemoradiation therapy, Esophageal cancer

Organism: Human, Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

443
Ultralong circulating choline phosphate liposomal nanomedicines for cascaded chemo-radiotherapy

X Li, Y Zhao, W Jiang, S Li, M Zhan, H Liu, C Zhang, H Liang, H Liu, L Lu, Y Wang

Biomaterials Science (Royal Society of Chemistry) China, 14 February 2019

Nanomedicine

Key words: Cascaded chemo-radiotherapy, hypoxia-activated therapy, tumor hypoxia, ultralong circulating liposome

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

444
The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental Study on Porcine Models

T Andrašina, J Jaroš, T Jůza, T Rohan, D Červinka, M Crha, V Válek, NS Goldberg

Cardiovascular and Interventional Radiology (Springer) Czech Republic, Israel, 13 February 2019

Hepathology

Key words: Liposomal doxorubicin, Radiofrequency ablation, Irreversible electroporation

Organism: Pig

Tissue: Liver

445
Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs

CM Lee, JH Liao, SH Chen, CH Yen, YC Lee, S Huang, S Huang, C Lin, VH Chang

Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan, 07 February 2019

Pulmonology

Key words: Fluorine, Rutaecarpine, Cyclooxygenase-2 , Anti-inflammatory Effects

Organism: Mouse

Tissue: Whole Organism

446
Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma

Jing Liu, Wenna Jiang, Kaili Zhao, Hongwei Wang, Tianxing Zhou, Weiwei Bai, Xiuchao Wang, Tiansuo Zhao, Chongbiao Huang, Song Gao, Tai Qin, Wenwen Yu, Bo Yang, Xin Li, Danqi Fu, Wei Tan, Shengyu Yang, He Ren, Jihui Hao

Journal of Experimental Medicine (Rockefeller University Press) China, USA, 07 February 2019

Oncology

Key words: EHF, anti-PD1 therapy, adenocarcinoma, pancreas

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

447
Generation of human iPSCs from fetal prostate fibroblasts HPrF

Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Radek Vrtěl, Lucie Jurečková, Volodymyr Porokh, Darja Páralová, Aleš Hampl, Karel Souček

Stem Cell Research (Elsevier) Czech Republic, 07 February 2019

Stem Cell Research

Key words: induced stem cells, iPSCs, prostate fibroblasts, HPrF

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

448
Multimodal imaging guides surgical management in a preclinical spinal implant infection model

Stephen D. Zoller, Howard Y. Park, Tove Olafsen, Charles Zamilpa, Zachary D.C. Burke, Gideon Blumstein, William L. Sheppard, Christopher D. Hamad, Kellyn R. Hori, Jen-Chieh Tseng, Julie Czupryna, Craig McMannus, Jason T. Lee, Mafalda Bispo, Francisco Romero Pastrana, Elisa J.M. Raineri, Jeffery F. Miller, Lloyd S. Miller, Jan Maarten van Dijl, Kevin P. Francis, Nicholas M. Bernthal

The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, The Netherlands, 07 February 2019

Osteology

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spine implant infection

449
EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke

Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H. Marti1, Thomas Korff and Reiner Kunze

Acta Neuropathologica (Springer) Germany, 05 February 2019

Neuroscience

Key words: EphB2, Ephrin-B2, Excitotoxicity, Inflammation, Ischemic stroke, NMDA

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

450
HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis

Björn Corleis, Allison N. Bucsan, Maud Deruaz, Vladimir D. Vrbanac, Antonella C. Lisanti-Park, Samantha J. Gates, Alice H. Linder, Jeffrey M. Paer, Gregory S. Olson, Brittany A. Bowman, Abigail E.S chiff, Benjamin D. Medoff, Andrew M.Tager, Andrew D. Luster, Shabaana A. Khader, Deepak Kaushal, Douglas S. Kwon

Cell Reports (Cell Press) USA, 05 February 2019

Pulmonology

Key words: HIV-1, CD4+ T cells, cell death, tuberculosis, HIV/TB co-infection, lung, BAL

Organism: Mouse

Tissue: Lung, Spleen

Pathological State: Virus Infection

451
Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade

Chien-Chun Steven Pai, John T. Huang, Xiaoqing Lu, Donald M. Simons, Chanhyuk Park, Anthony Chang, Whitney Tamaki, Eric Liu, Kole T. Roybal, Jane Seagal, Mingyi Chen, Katsunobu Hagihara, Xiao X. Wei, Michel DuPage, Serena S. Kwek, David Y. Oh, Adil Daud, Katy K. Tsai, Clint Wu, Li Zhang, Marcella Fasso, Ravi Sachidanandam, Anitha Jayaprakash, Ingrid Lin, Amy-Jo Casbon, Gillian A. Kinsbury, Lawrence Fong

Immunity (Cell Press) USA, 05 February 2019

Oncology

Key words: cancer immunotherapy IFN-γ activation-induced cell death anti-CTLA-4 anti-PD-1

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

452
Hypoxic changes to the urothelium as a bystander of end-stage bladder disease

Anna Radford, Dr Jenny Hinley, Dr Alice Pilborough, Jennifer Southgate, Ramnath Subramaniam

Journal of Pediatric Urology (Elsevier) UK, 05 February 2019

Urology

Key words: Neuropathic bladder, Hypoxia, Hypoxia-inducible factor1 alpha, Obstruction, Regenerative medicine

Organism: Human

Pathological State: Neuropathy

453
Spatiotemporal Differences in Presentation of CD8 T Cell Epitopes during Hepatitis B Virus Infection

Atefeh Khakpoor, Yi Ni, Antony Chen, Zi Zong Ho, Vincent Oei, Ninghan Yang, Reshmi Giri, Jia Xin Chow, Anthony T. Tan, Patrick T. Kennedy, Mala Maini, Stephan Urban, Antonio Bertoletti

Journal of Virology (American Society for Microbiology) Singapore, Germany, Belgium, UK, 05 February 2019

Virology

Key words: antigen presentation, CD8 T cells, chronic hepatitis B patient, HBV DNA integration, HLA class I, liver, hepatitis B virus

Organism: Human

Tissue: Liver

Pathological State: Virus Infection

454
DSE regulates the malignant characters of hepatocellular carcinoma cells by modulating CCL5/CCR1 axis

WC Liao, HR Yen, CK Liao, TJ Tseng, CT Lan, CH Liu

American Journal of Cancer Research (NCBI) Taiwan, 01 February 2019

Oncology

Key words: Dermatan sulfate, DS epimerase, hepatocellular carcinoma, tumor infiltrated lymphocyte, CCL5

Organism: Human

Tissue: Liver

Pathological State: Cancer

455
Pathology of spontaneous and immunotherapy‐induced tumor regression in a murine model of melanoma

Kim R M Blenman, Jake Wang, Shawn Cowper, Marcus Bosenberg

Pigment Cell and Melanoma Research (Wiley) USA, 31 January 2019

Oncology

Key words: melanoma, mouse models, B cells, neutrophils, Ly6B.2, histology, tumor regression, NETs

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

456
COPD and asthma therapeutics for supportive treatment in organophosphate poisoning

J Herbert, H Thiermann, F Worek, T Wille

Clinical Toxicology (Taylor and Francis) Germany, 30 January 2019

Toxicology

Key words: Organophosphate poisoning, nerve agents, PCLS, COPD, asthma

Organism: Rat

Tissue: Lung

457
Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages

Dominique Muschter , Anna-Sophie Beiderbeck , Tanja Späth, Christian Kirschneck, Agnes Schröder, Susanne Grässel

International Journal of Molecular Sciences (MDPI) Germany, 24 January 2019

Immunology

Key words: cyclic stretch, mechan-oregulation, murine macrophages, substance P, alpha-calcitonin gene-related peptide, neurokinin receptor, CGRP receptor, destabilized medial meniscus

Organism: Mouse

Pathological State: Osteoarthritis

Cell Line: Bone Marrow-derived Macrophages

458
Multiple defects sensitize p53-deficient head and neck cancer cells to the WEE1 kinase inhibition

Ahmed Diab, Micheal Kao, Keffy Kehrli, Hee Yeon Kim, Julia Sidorova and Eduardo Méndez

Molecular Cancer Research (AACR Publications) USA, 24 January 2019

Oncology

Key words: Head and neck cancer, WEE1, TP53, cell cycle, mitosis, replication stress, DNA damage

Organism: Human

Cell Line: Primary fibroblast cells (HFF4), Head and neck cancer cell line UM-SCC-74a

459
Safe Nanocomposite‐Mediated Efficient Delivery of MicroRNA Plasmids for Autosomal Dominant Polycystic Kidney Disease (ADPKD) Therapy

Yen‐Chang Tsai I‐Ling Teng Si‐Tse Jiang Yi‐Che Lee Yuan‐Yow Chiou Fong‐Yu Cheng

Advanced Healthcare Materials (Wiley) Taiwan, 23 January 2019

Nanomedicine

Key words: ADPKD, microRNA, MR,I nanoparticles, plasmid DNA

Organism: Mouse

Tissue: Kidney

Pathological State: Polycystic Kidney Disease

460
Dynamic changes in intramedullary pressure 72 hours after spinal cord injury

Xin Zhang, Chang-Bin Liu, De-Gang Yang, Chuan Qin, Xue-Chao Dong, Da-Peng Li, Chao Zhang, Yun Guo, Liang-Jie Du, Feng Gao, Ming-Liang Yang PhD , Jian-Jun Li

Neural Regeneration research (Publishing House of Neural Regeneration Research) China, 23 January 2019

Neuroscience

Key words: anesthetized, blood-spinal barrier, conscious, edema, hemorrhage, nerve regeneration, neural regeneration, pathological mechanism, pressure measurement, rabbit, secondary spinal cord injury, telemetry

Organism: Rabbit

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

461
Chronic thromboembolic pulmonary hypertension in Austria and Japan

Stella Chausheva, Akira Naito, Aiko Ogawa, Veronika Seidl, Max-Paul Winter, Smriti Sharma, Roela Sadushi-Kolici, Ioana-Alexandra Campean, Shahroukh Taghavi, Bernhard Moser, Walter Klepetko, Keiichi Ishida, Hiromi Matsubara, Seiichiro Sakao, Irene M.Lang

The Journal of thoracic and cardiovascular surgery (Elsevier) Austria, Japan, 21 January 2019

Cardiology

Key words: Chronic thromboembolic pulmonary hypertension, pulmonary endarterectomy, balloon pulmonary angioplasty,

462
Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition

Kristyna Karova, John V. Wainwright, Lucia Machova-Urdzikova, Rishikaysh V. Pisal, Meic Schmidt, Pavla JendelovaEmail author and Meena Jhanwar-UniyalEmail author

Journal of Neuroinflammation (Springer) Czech Republic, USA, 17 January 2019

Stem Cell Research

Key words: NF-κB, p65, Spinal cord injury, Stem cells transplantation, Inflammation, TNF-α,

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

463
The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

Lindsay Kosack, Bettina Wingelhofer, Alexandra Popa, Bojan Vilagos, Anna Orlova, Peter Majek, Katja Parapatics, Alexander Lercher, Benedikt Agerer, Anna Ringler, Johanna Klughammer, Mark Smyth, Kseniya Khamina, Hatoon Baazim, David A. Rosa, Jisung Park, Patrick T. Gunning, Christoph Bock, Hannah V. Siddle, Stefan Kubicek, Elizabeth P. Murchison, Keiryn L. Bennett, Richard Moriggl, View ORCID ProfileAndreas Bergthaler

Cancer Cell (Cell Press) Austria, Canada, UK, Australia, 14 January 2019

Oncology

Key words: ERBB, horizontal transmission, MHC class I, receptor tyrosine kinases, STAT3, Tasmanian devil, transmissible cancer, tumor vulnerability, systems biology xenograft

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

464
Probiotic Lactobacillus spp. Act Against Helicobacter pylori-induced Inflammation

Yi-Hsing Chen, Wan-Hua Tsai, Hui-Yu Wu, Chun-Ya Chen, Wen-Ling Yeh, Ya-Hui Chen, Hui-Ying Hsu, Wei-Wei Chen, Yu-Wen Chen, Wen-Wei Chang, Tzu-Lung Lin, Hsin-Chih Lai, Yu-Hsin Lin and Chih-Ho Lai

Journal of Clinical Medicine (MDPI) Taiwan, 14 January 2019

Microbiology

Key words: Helicobacter pylori, Lactobacillus, probiotic, inflammation

Organism: Mouse

Tissue: Stomach

Pathological State: Bacterial Infection

465
Brain-Derived Neurotrophin and TrkB in Head and Neck Squamous Cell Carcinoma

Dudás J, Riml A, Tuertscher R, Pritz C, Steinbichler TB, Schartinger VH, Sprung S, Glueckert R, Schrott-Fischer A, Johnson Chacko L, Riechelmann H

International Journal of Molecular Sciences (MDPI) Austria, 11 January 2019

Oncology

Key words: epithelial–mesenchymal transition, vimentin, cytokeratin, p53 mutation, paraffin embedding, riboprobe

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

466
An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes

Ruiying Wang, Min Wang, Shan Wang, Ke Yang, Ping Zhou, Xueheng Xie, Qi Cheng, Jingxue Ye, Guibo Sun and Xiaobo Sun

Stem Cell Research and Therapy (Springer) China, 11 January 2019

Stem Cell Research

Key words: Cardiotoxicity, Sophora tonkinensis, hiPSC-CMs, Cardio-NLCS

Organism: Human

Cell Line: Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

467
Clinical significance of c-Met and phospho-c-Met (Tyr1234/1235) in ovarian cancer

L Lim, CC Wu, YT Hsu, FJ Sun, CL Chang

Taiwanese Journal of Obstetrics and Gynecology (Elsevier) Taiwan, 09 January 2019

Oncology

Key words: c-Met, phospho-c-Met, Ovarian cancer

Organism: Human

Tissue: Breast

Pathological State: Cancer

468
High-Throughput Synapse-Resolving Two-Photon Fluorescence Microendoscopy for Deep-Brain Volumetric Imaging In Vivo

Guanghan Meng, Yajie Liang, Sarah Sarsfield, Wan-chen Jiang, Rongwen Lu, Joshua Tate Dudman, Yeka Aponte, Na Ji

eLife (eLife Sciences Publications) USA, 03 January 2019

Neuroscience

Key words: two-photon fluorescence microendoscopy, volumetric imaging, Bessel beam, hippocampus, lateral hypothalamus

Organism: Mouse

Tissue: Brain

469
Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain

Qing Yu, Ying-Zi Liu, Yan-Bing Zhu, Yao-Yi Wang, Qian Li, Dong-Min Yin

Brain Structure and Function (Springer) China, 02 January 2019

Neuroscience

Key words: Drd2, Knockin rats, Olfactory bulb, Cerebral cortex, Hippocampus 

Organism: Mouse, Rat

Tissue: Brain

470
Abundance of the Organic Anion-transporting Polypeptide OATP4A1 in Early-Stage Colorectal Cancer Patients: Association With Disease Relapse

V Buxhofer-Ausch, M Sheikh, C Ausch, S Zotter, H Bauer, M Mollik, A Reiner, A Gleiss, W Jäger, C Sebesta, S Kriwanek, T Thalhammer

Applied Immunohistochemistry & Molecular Morphology (Ingentaconnect) Austria, 01 January 2019

Oncology

Key words: OATP4A1, SLCO4A1, automated microscopic imaging system, colorectal cancer, relapse

Organism: Human

Tissue: Colon

Pathological State: Cancer

471
Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes

Natalie M Frederick, Parth V Shah, Alessandro Didonna ,Monica R Langley, Anumantha G Kanthasamy, Puneet Opal

Human Molecular Genetics (Oxford University Press) USA, 26 December 2018

Neuroscience

Key words: alleles, phenotype, dopamine, signal transduction, transcription, genetic basal ganglia dystonia homeostasis cytoskeleton embryo genes gliosis mice, knockout movement disorders rna, messenger synaptic transmission up-regulation (physiology) zinc fingers cerebellum mice transcription factor agonists antagonists haploinsufficiency nervous system development nestin protein torsion dystonia 6 loss of function mutation

Organism: Mouse

Tissue: Brain

472
Effects of cylindrospermopsin on cultured immortalized human airway epithelial cells

Barbara Kubickova, Petra Laboha, Jan-Peter Hildebrandt, Klara Hilscherová, Pavel Babica

Chemosphere (Elsevier) Czech Republic, Germany, 22 December 2018

Toxicology

Key words: Cyanobacteria, Cyanotoxin, HBE, Inhalation toxicity, MAPK

Organism: Human

Cell Line: Human bronchial epithelial cell line (HBE) 16HBE14o-cells

473
Histo-genomics: digital pathology at the forefront of precision medicine

Mark L. Graber, Mario Plebani

Diagnosis (De Gruyter) Canada, 20 December 2018

Pathology

474
Spatial mapping of myeloid cells and macrophages by multiplexed tissue staining

Joshua Saylor, Zhaoxuan Ma, Helen S. Goodridge, Fangjin Huang, Anne E. Cress, Stephen J. Pandol, Stephen L. Shiao, Adriana C. Vidal, Lily Wu, Nicholas G. Nickols, Arkadiusz Gertych and Beatrice S. Knudsen

Frontiers in Immunology (Frontiers Media S.A.) USA, 14 December 2018

Immunology

Key words: FFPE, immunofluorescence, immunohistochemistry, macrophage, multiplex, myeloid, spatial profiling

Organism: Human

Tissue: Colon, Tonsil

Pathological State: Cancer

475
Predominant Striatal Input to the Lateral Habenula in Macaques Comes from Striosomes

Simon Hong, Satoko Amemori, Emily Chung, Daniel J. Gibson, Ken-ich iAmemori , Ann M.Graybiel

Current Biology (Cell Press) USA, Japan, 13 December 2018

Neuroscience

Key words: basal ganglia, dopamine, motivation, non-human primate, mood, learning, microstimulation

Organism: Monkey

Tissue: Brain

476
Melanocyte-specific gene 1 promotes melanoma progression by enhancing the expression of Bcl-2

Hui Zhao, Guosheng Wu, Ji Zhu, Mengyan Sun, Yuchong Wang, Yongjie Fan, Kai Wu, Hongda Bi, Haiying Dai, Chuan Lv, Chunyu Xue

Oncology Letters (Spandidos Publications) China, 12 December 2018

Oncology

Key words: melanocyte-specific gene 1, melanoma, cell viability, apoptosis, Bcl-2

Organism: Human

Tissue: Skin

Pathological State: Cancer

477
The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma

Viktoria Laszlo, Zsuzsanna Valko, Judit Ozsvar, Ildiko Kovacs, Tamas Garay, Mir Alireza Hoda, Thomas Klikovits, Paul Stockhammer, Clemens Aigner, Marion Gröger, Walter Klepetko, Walter Berger, Michael Grusch, Jozsef Tovari, Irene C. Waizenegger, Balazs Dome, Balazs Hegedus

Journal of Molecular Medicine (Springer) Austria, Germany, Hungary, 11 December 2018

Oncology

Key words: Mesothelioma, Focal adhesion kinase, Tyrosine kinase inhibitor, Angiogenesis, Spheroid formation, Orthotopic xenograft

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

478
Anti-inflammatory compound curcumin and mesenchymal stem cells in the treatment of spinal cord injury in rats.

Jiri Ruzicka, Lucia Machova Urdzikova, Anna Kloudova, Anubhav G. Amin, Jana Vallova, Sarka Kubinova, Meic H. Schmidt, Meena Jhanwar‑Uniyal and Pavla Jendelova

Acta Neurobiologiae Experimentalis (Nencki Institute of Experimental Biology) Czech Republic, USA, 05 December 2018

Regenerative Medicine

Key words: Spinal cord injury, human mesenchymal stem cells, curcumin, combined therapy, inflammatory response

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

Cell Line: Human mesenchymal stem cells (hMSCs)

479
The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma

Ying Liu, Xinhua Wang, Shuang Zeng, Xiane Zhang, Jimin Zhao, Xiaoyan Zhang, Xinhuan Chen, Wanjing Yang, Yili Yang, Ziming Dong, Jingyu Zhu Xin Xu, Fang Tian

Journal of Experimental and Clinical Cancer Research (Springer) China, 05 December 2018

Oncology

Key words: Curcumin, STAT3, Esophageal squamous cell carcinoma, Apoptosis, PDX model

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

480
Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression

Bing Song, Su-Hong Park, Jonathan C. Zhao, Ka-wing Fong, Shangze Li, Yongik Lee, Yeqing A. Yang, Subhasree Sridhar, Xiaodong Lu, Sarki A. Abdulkadir, Robert L. Vessella, Colm Morrissey, Timothy M. Kuzel, William J. Catalona, Ximing J. Yang, and Jindan Yu

Journal of Clinical Investigation (American Society for Clinical Investigation) USA, China, 04 December 2018

Oncology

Key words: Genetics, Oncology, Prostate cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

481
CXCL5 as regulator of neutrophil function in cutaneous melanoma

A Forsthuber, K Lipp, L Andersen, S Ebersberger, O Grana-Castro, W Ellmeier, P Petzelbauer, BM Lichtenberger, R Loewe

Journal of Investigative Dermatology (Elsevier) Austria, Germany, Spain, 04 December 2018

Oncology, Dermatology

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

482
Extracellular vesicles from mature dendritic cells (DC) differentiate monocytes into immature DC

Stefan Schierer, Christian Ostalecki, Elisabeth Zinser, Ricarda Lamprecht, Bianca Plosnita, Lena Stich, Jan Dörrie, ProfileManfred B Lutz, ProfileGerold Schuler, ProfileAndreas S Baur

Life Science () Germany, Austria, 03 December 2018

Immunology

Key words: Medical Research, Immunology

Organism: Human, Mouse

Cell Line: Monocyte-derived dentritic cells

483
Elevated Serum Interleukin-8 Level Correlates with Cancer-Related Cachexia and Sarcopenia: An Indicator for Pancreatic Cancer Outcomes

Ya-Chin Hou , Chih-Jung Wang , Ying-Jui Chao , Hao-Yun Chen , Hao-Chen Wang, Hui-Ling Tung , Jung-Ting Lin and Yan-Shen Shan

Journal of Clinical Medicine (MDPI) Taiwan, 01 December 2018

Oncology

Key words: pancreatic cancer, cancer cachexia, sarcopenia, interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

484
Freshwater cyanotoxin cylindrospermopsin has detrimental stage-specific effects on hepatic differentiation from human embryonic stem cells

Tereza Vanova, Jan Raska, Pavel Babica, Iva Sovadinova, Michaela Kunova Bosakova, Petr Dvorak Ludek Blaha, Vladimir Rotrekl

Toxicological Sciences (Oxford University Press) Czech Republic, 30 November 2018

Stem Cell Research

Key words: cylindrospermopsin, hepatic differentiation, human embryonic stem cells, liver, cyanotoxin

Organism: Human

Cell Line: Human embryonic stem cell (hESCs)

485
Pterostilbene Attenuates Hexavalent Chromium-Induced Allergic Contact Dermatitis by Preventing Cell Apoptosis and Inhibiting IL-1β-Related NLRP3 Inflammasome Activation

Bour-Jr Wang , Hui-Wen Chiu, Yong-Lin Lee, Chia-Yi Li, Ying-Jan Wang, and Yu-Hsuan Lee

Journal of Clinical Medicine (MDPI) Taiwan, 27 November 2018

Allergy Research

Key words: Hexavalent chromium, pterostilbene, endoplasmic reticulum stress, inflammatory cytokines, NLRP3 inflammasome, allergic contact dermatitis

Organism: Mouse

Tissue: Skin

Pathological State: Dermatitis

486
ONECUT2 Is a Targetable Master Regulator of Lethal Prostate Cancer That Suppresses the Androgen Axis

Mirja Rotinen, Sungyong You, Julie Yang, Simon G. Coetzee, Mariana Reis-Sobreiro, Wen-Chin Huang, Fangjin Huang, Xinlei Pan, Alberto Yáñez, Dennis J. Hazelett, Chia-Yi Chu, Kenneth Steadman, Colm M. Morrissey, Peter S. Nelson, Eva Corey, Leland W. K. Chung, Stephen J. Freedland, Dolores Di Vizio, Isla P. Garraway, Ramachandran Murali, Beatrice S. Knudsen & Michael R. Freeman

Nature Medicine (Nature) USA, Taiwan, 26 November 2018

Oncology

487
Immune Cell and Cell Cluster Phenotyping, Quantitation, and Visualization Using In Silico Multiplexed Images and Tissue Cytometry

Kim R.M. Blenman, Marcus W. Bosenberg

Cytometry Part A (Wiley) USA, 23 November 2018

Cytometry

Key words: immune cells, cell clusters, quantitative imaging, multiplexed histology, tissue cytometry, TissueFAXS in silico analysis, FFPE

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

488
PD-L1 expression and the prognostic significance in gastric cancer: a retrospective comparison of three PD-L1 antibody clones (SP142, 28–8 and E1L3N)

Jing Ma, Jianhui Li, Meirui Qian, Weili Han, Miaomiao Tian, Zengshan Li, Zhe Wang, Shuixiang He and Kaichun Wu

Diagnostic Pathology (Springer) China, 21 November 2018

Oncology

Key words: Programmed cell death ligand 1, Immunohistochemistry, H-score, Multiplexed immunofluorescence

Organism: Human

Tissue: Stomach

Pathological State: Cancer

489
MicroRNA-451a overexpression induces accelerated neuronal differentiation of Ntera2/D1 cells and ablation affects neurogenesis in microRNA-451a-/- mice

Christa Trattnig , Muammer Üçal , Carmen Tam-Amersdorfer, Angela Bucko, Ulrike Zefferer, Gerda Grünbacher, Markus Absenger-Novak, Kristin Anna Öhlinger, Klaus Kraitsy, Daniel Hamberger, Ute Schaefer , Silke Patz

PLoS One (PLOS) Austria, 21 November 2018

Neuroscience

Key words: Neuronal differentiation, Neurites, Cell differentiation, Neurospheres, MicroRNAs , Neural networks, Fluorescence microscopy, Nestin

Organism: Mouse

Tissue: Brain

490
Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging

Annunziata N. Crupi , Jordan S. Nunnelee , David J. Taylor , Amandine Thomas , Jean-Philippe Vit , Celine E. Riera 5 , Roberta A. Gottlieb , Helen S. Goodridge

Aging (Impact Journals) USA, 18 November 2018

Physiology

Key words: Aging, glycolytic, mitochondria, oxidative, sarcopenia, skeletal muscle

Organism: Mouse

Tissue: Muscle

491
Hepatocellular carcinoma-targeted nanoparticles for cancer therapy

Chien-Hsun Wu, Chun-Hsin Lan, Kuan-Lin Wu, Yao‑Ming Wu, Wann-Neng Jane , Michael Hsiao, Han-Chung Wu

International Journal of Oncology (Spandidos Publications) Taiwan, 16 November 2018

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

492
Generation of human iPSCs from human prostate cancer-associated fibroblasts IBPi002-A

Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Daniela Kurfűrstová, Radek Vrtěl, Vladimír Študent, Lucie Jurečková, Volodymyr Porokh, Aleš Hampl, Karel Souček

Stem Cell Research (Elsevier) Czech Republic, 16 November 2018

Stem Cell Research

Key words: induced stem cells, iPSCs, prostate fibroblasts, IBPi00-2

Organism: Human

Cell Line: Induced pluripotent cells (iPSCs)

493
Effect of dentin matrix components on the mineralization of human mesenchymal stromal cells

Dr. Xenos Petridis, Mr. Bas Pieter Beems, Dr. Phillip Tomson, Dr. Ben Scheven, Dr. Ben Giepmans, Dr. Jeroen Kuipers, Dr. Luc van der Sluis, Dr. Martin C Harmsen

Tissue Engineering Part A (Mary Ann Liebert Inc.) The Netherlands, UK, 16 November 2018

Regenerative Medicine

Key words: dental pulp, dentin matrix, mesenchymal stromal cells, mineralization, tissue engineering, umbilical cord

Organism: Human

Cell Line: Dental pulp stem cells (DPSCs), Adipose tissue derived stem cells (ASCs)

494
Semi-Automated and Manual Methods for Counting Cells Expressing P75 Receptor in Endometriotic Lesions

Dewanto Agung, Sun Xiaoyan, Dudas Jozsef, Gluekert Rudolf, Schrott-Fischer Anneliese, W. D. Ludwig, Seeber Beata

() Indonesia, Austria, 12 November 2018

Cytometry

Key words: Observers,Immune system,Software,Lesions,Manuals,Biomedical imaging,Tools

495
Novel Protective Effects of Cistanche Tubulosa Extract Against Low-Luminance Blue Light-Induced Degenerative Retinopathy

Man-Ru Wua, Cheng-Hui Lina, Jau-Der Hob, George Hsiaoc, Yu-Wen Cheng

Cellular Physiology and Biochemistry (Karger) Taiwan, 07 November 2018

Ophthalmology

Key words: Cistanche tubulosa extract • Blue light • Apoptosis • Retinal pigment epithelial cells

Organism: Human

Cell Line: Retinal pigment epithelium cells (RPEs)

496
Increased frequency of systemic pro-inflammatory Vδ1+ γδ T cells in HIV elite controllers correlates with gut viral load

Gregory S. Olson, Sarah W. Moore, James M. Richter, John J. Garber, Brittany A. Bowman, Crystal A. Rawlings, Meaghan Flagg, Björn Corleis and Douglas S. Kwon

Scientific Reports (Nature) USA, 07 November 2018

Immunology, Virology

Key words: Chronic inflammation, Gammadelta T cells, HIV infections, Infection, Mucosal immunology

Organism: Human

Tissue: Small Intestine

Pathological State: Virus Infection

497
Loss of BAP1 expression is associated with genetic mutation and can predict outcomes in gallbladder cancer

Takashi Hirosawa, Masaharu Ishida , Kentaro Ishii, Keigo Kanehara, Katsuyoshi Kudo, Shinobu Ohnuma, Takashi Kamei, Fuyuhiko Motoi, Takeshi Naitoh, Florin M. Selaru, Michiaki Unno

PLoS One (PLOS) Japan, USA, 05 November 2018

Oncology

Key words: DNA methylation ,Small interfering RNAs ,Polymerase chain reaction ,Methylation ,Mutation detection ,Prognosis ,DNA sequence analysis ,Nonsense mutation

Organism: Human

Pathological State: Cancer

498
Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice

Caroline Arnold, Anja Feldner, Maren Zappe, Dorde Komljenovic, Carolina De La Torre, Philipp Ruzicka, Markus Hecker, Wolfgang Neuhofer, and Thomas Korff

The FASEB Journal (FASEB) Germany, 01 November 2018

Regenerative Medicine

Key words: hypertension, wall stress, transcriptome

Organism: Mouse

Cell Line: Primary aterial smooth muscle cells, vascular smooth muscle cells (VSMCs )

499
Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow-and pressure-induced arterial remodeling in mice

Caroline Arnold, Anja Feldner, Maren Zappe, Dorde Komljenovic, Carolina De La Torre, Philipp Ruzicka, Markus Hecker, Wolfgang Neuhofer, and Thomas Korff

The FASEB Journal (FASEB) Germany, 01 November 2018

Cardiology

Key words: hypertension, wall stress, transcriptome

Organism: Mouse

Cell Line: Vascular Smooth Muscle Cells

500
Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis

Helen Ashwin , Karin Seifert , Sarah Forrester , Najmeeyah Brown , Sandy MacDonald , Sally James , Dimitris Lagos , Jon Timmis , Jeremy C Mottram , Simon L. Croft , Paul M. Kaye

Wellcome Open Research (Wellcome Open Research) UK, 29 October 2018

Parasitology

Key words: Leishmania, infection, host response, transcriptomics, immunopathology

Organism: Mouse

Tissue: Spleen, Liver

Pathological State: Parasitic Infection

501
Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy

Ying Zhoua, Mrinmoy Maitib, Amit Sharmac, Miae Won, Le Yu, Lan Xi, Miao, Jinwoo Shin, Arup Podder, Kondapa Naidu Bobba, Jiyou Han, Sankarprasad Bhuniya, Jong Seung Kim

Journal of Controlled Release (Elsevier) China, India, South Korea, 28 October 2018

Oncology

Key words: molecular hypoxia, theranostic, tumor-specific imaging,

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

502
PI3K: A master regulator of brain metastasis‐promoting macrophages/microglia

Raquel Blazquez Darius Wlochowitz Alexander Wolff Stefanie Seitz Astrid Wachter Julia Perera‐Bel Annalen Bleckmann Tim Beißbarth Gabriela Salinas Markus J. Riemenschneider Martin Proescholdt Matthias Evert Kirsten Utpatel Laila Siam Bawarjan Schatlo Marko Balkenhol Christine Stadelmann Hans‐Ulrich Schildhaus Ulrike Korf Eileen Reinz Stefan Wiemann Elena Vollmer Mathias Schulz Uwe Ritter Uwe K. Hanisch Tobias Pukrop

GLIA (Wiley) Germany, 25 October 2018

Oncology

Key words: Astrocytes, BKM120, brain metastasis, macrophages, microglia, PI3K, RPPA

Organism: Mouse

Pathological State: Cancer

Cell Line: Monocyte‐derived macrophages (MDMs)

503
Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Wei-TaChen, Wei-Tse Hsu, Meng-Hua Yen, Chun A. Changou, Chia-Li Han, Yu-Ju Chen, Ji-Yen Cheng, Tzu-Hao Chang, Oscar Kuang-Sheng Lee, Jennifer Hui-Chun Ho

Biomaterials (Elsevier) Taiwan, 23 October 2018

Stem Cell Research

Key words: β-catenin, Cardiovascular, Laminar shear, Mesenchymal stem cells, Wnt

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

504
Gene expression profiling in a mouse model of Dravet syndrom

Nicole A.Hawkins, Jeffrey D.Calhoun, Alexandra M.Huffman, Jennifer A.Kearney

Experimental Neurology (Elsevier) USA, 19 October 2018

Neuroscience

Key words: Epilepsy, Epileptic encephalopathy, Gene expression, RNA-seq, Seizure, Voltage-gated sodium channel

Organism: Mouse

Tissue: Brain

Pathological State: Dravet Syndrome

505
Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation

Janaina M. Alves, Antonio H. Martins, Claudiana Lameu, Talita Glaser, Nawal M. Boukli, Vinicius Bassaneze, Rafael Dariolli, Isis C. Nascimento, Poliana C. M. Martins, Héllio D. N. de Souza, José Eduardo Krieger, Dulce E. Casarini, Vicencia M. Sales, João B. Pesquero, Henning Ulrich

Stem cell reviews and reports (Springer) USA, Brazil, 18 October 2018

Stem Cell Research

Key words: Mouse myoblast differentiation, Muscle repair, Kinin-B2 receptor, HOE-140

Organism: Mouse

Cell Line: Myoblast cell line - C2C12 Cells

506
Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

Mera vCohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit

CELL (Cell Press) Israel, Austria, Sweden, 11 October 2018

Cell Biology

Key words: immune systemsingle-cell RNA sequencinglungbasophilsalveolar macrophagescellular interactiondevelopmentsignaling

Organism: Mouse

Tissue: Lung

507
Early Immunologic Response of Irreversible Electroporation versus Cryoablation in a Rodent Model of Pancreatic Cancer

Sarah B. White, MD, MS, FSIR, Zhouli Zhang, MD, PhD, Jeane Chen, PhD, Venkateswara R. Gogineni, PhD, and Andrew C. Larson, PhD

Journal of Vascular and Interventional Radiology (Elsevier) USA, 11 October 2018

Immunology

Key words: irreversible electroporation, Cryoablation, Pancreatic Cancer

Organism: Mouse

Pathological State: Cancer

Cell Line: PANC-2 (Pancreatic cancer cell line)

508
Transforming growth factor beta 1 mediates the low-frequency vertical vibration enhanced production of tenomodulin and type I collagen in rat Achilles tendon

Chia-Hsin Chen, Yi-Hsiung Lin, Chung-Hwan Chen, Yan-Hsiung Wang, Ming-Long Yeh, Tsung-Lin Cheng, Chau-Zen Wang

PLoS One (PLOS) Taiwan, 11 October 2018

Cell Biology

Key words: Tendons ,Collagens ,Gene expression ,Stiffness ,Vibration ,Mechanical properties ,Enzyme-linked immunoassays ,Polymerase chain reaction

Organism: Rat

509
Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis

Yang WH, Heithoff DM, Aziz PV, Haslund-Gourley B, Westman JS, Narisawa S, Pinkerton AB, Millán JL, Nizet V, Mahan MJ, Marth JD

Cell Host and Microbe (Cell Press) USA, 10 October 2018

Immunology, Microbiology

Key words: glycosylation, sepsis, neuraminidase, Toll-like receptor 4, alkaline phosphatase, Ashwell-Morell receptor, lipopolysaccharide, inflammation

Organism: Mouse

Tissue: Liver

Pathological State: Sepsis

510
Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors

Hye Jung Baek, Sun Eui Kim, Jong Kwang Kim, Dong Hoon Shin, Tae Hyun Kim, Kwang Gi Kim, Chu-Xia Deng, Sang Soo Kim

International Journal of Biological Sciences (Ivyspring International Publisher) South Korea, China, 10 October 2018

Oncology

Key words: BRCA1, AKT, MK-2206, precision medicine

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

511
Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

Quan-Liang Jian​, Wei-Chun HuangFu​, Yen-Hua Lee, I-Hsuan Liu​

The Journal of Life and Environmental Sciences (PeerJ) Taiwan, 01 October 2018

Osteology

Key words: Aging, Cartilage, Osteoarthritis, Tissue homeostasis, Chondrocyte

Organism: Fish

Tissue: Spinal Cord

512
Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells

Kang-Hao Liang, Hsien-Cheng Tso, Shao-Hsi Hung, I.-I. Kuan, Jun-Kai Lai, Feng-Yi Ke, Yi-Ting Chuang, I-Ju Liu, Yi-Ping Wang, Ruey-Hwa Chen, Han-Chung Wu

Cancer Letters (Elsevier) Taiwan, 01 October 2018

Oncology

Key words: Epithelial cell adhesion molecule, Regulated intramembrane proteolysis, β-catenin, HIF1α

Organism: Human

Tissue: Colon

Pathological State: Cancer

513
Gd-EOB-DTPA DCE-MRI biomarkers in a rabbit model of liver fibrosis

Yang Ji, Chuanshan Zhang, Zhe Huang, Xia Wang, Lina Yue, Meimei Gao, Huiling Hu, Qinjun Su, Yuedong Han, Bin Liu, Ding Yang, Zhanliang Su, Zhuoli Zhang

American Journal of Translational Research (e-Century Publishing Corporation) China, USA, 30 September 2018

Hepathology

Key words: Liver fibrosis, animal, magnetic resonance imaging, pathology

Organism: Rabbit

Tissue: Liver

Pathological State: Fibrosis, Liver Cirrhosis

514
Modified Ginseng Extract Induces Apoptosis in HepG2 Cancer Cells by Blocking the CXCL8-Mediated Akt/Nuclear Factor-κB Signaling Pathway

Zhen Yang Cui, Eunbi Jo, Hyun Jin Jang, In-Hu Hwang, Kyung-Bok Lee, Hwa-Seung Yoo, Soo Jung Park, Mi-Kyung Jung, Yeon Wol Lee and Ik-Soon Jang

The American Journal of Chinese Medicine (World Scientific) South Korea, 27 September 2018

Oncology

Key words: Modified Regular Ginseng Extract, MRGX, C-X-C Motif Chemokine Ligand 8, Liver Cancer, Akt, Nuclear Factor-κB, Apoptosis

Organism: Human

Pathological State: Cancer

Cell Line: HepG2 (Liver carcinoma cell line)

515
Development of Decellularized Cornea by Organic acid Treatment for Corneal Regeneration

Mr. HungJun Lin, Dr. TsungJen Wang, Miss TingWei Li, Dr. YaoYuan Chang, Prof. Ming Thau Sheu, Prof. Yi-You Huang, Dr. Der-Zen Liu

Tissue Engineering Part A (Mary Ann Liebert Inc.) Taiwan, 22 September 2018

Regenerative Medicine

Key words: cornea, decellularized scaffold, extracellular matrix, xenograft, corneal transplantation.

Organism: Rabbit

Tissue: Eye

516
ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

Jacqueline A. Brosnan-Cashman, Ming Yuan, Mindy K. Graham, Anthony J. Rizzo, Kaylar M. Myers, Christine Davis, Rebecca Zhang, David M. Esopi, Eric H. Raabe, Charles G. Eberhart, Christopher M. Heaphy, Alan K. Meeker

PLoS One (PLOS) USA, 18 September 2018

Oncology

Key words: Telomeres, Cloning, Glioma cells ,Glioma ,DNA cloning ,Immunoblotting ,Vector cloning ,Polymerase chain reaction

Organism: Human

Pathological State: Cancer

Cell Line: Glioma cell lines (MOG-G-UVW, SF188, U-251 and UW479)

517
The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

Bohumil Fafilek, Lukas Balek, Michaela Kunova Bosakova, Miroslav Varecha, Alexandru Nita, Tomas Gregor, Iva Gudernova, Jitka Krenova, Somadri Ghosh, Martin Piskacek, Lucie Jonatova, Nicole H. Cernohorsky, Jennifer T. Zieba, Michal Kostas, Ellen Margrethe Haugsten, Jørgen Wesche, Christophe Erneux, Lukas Trantirek, Deborah Krakow, and Pavel Krejc

Science Signaling (American Association for the Advancement of Science) Czech Republic, Belgium, USA, Norway, 18 September 2018

Cell Biology

Key words: SHIP2, ERK activation, FGF receptors, Src kinases

Organism: Rat, Human

Pathological State: Cancer

Cell Line: U2OS (Osteosarcoma cell line), RCS cells (Cultured rat chondrosarcoma cell line)

518
Activation of estrogen receptor alpha induces beiging of adipocytes

Roberta S.Santos, Aaron P.Frank, Luciana A.Fátima, Biff F.Palmer, Deborah J.Clegg

Molecular Metabolism (Elsevier) USA, 15 September 2018

Cell Biology

Key words: Beige adipocytes, Lipolysis, Estrogen receptor alpha (ERα), Obesity, Type II diabetes mellitus (T2DM)

Organism: Mouse

Tissue: Adipose Tissue

519
Cellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model

Helen N. Schwerdt, Elizabeth Zhang, Min Jung Kim, Tomoko Yoshida, Lauren Stanwicks, Satoko Amemori, Huseyin E. Dagdeviren, Robert Langer, Michael J. Cima and Ann M. Graybiel

Communications Biology (Nature) USA,, 12 September 2018

Neuroscience

Key words: Diagnostic markers, Neurochemistry, Parkinson's disease, Sensors and probes

Organism: Rat

Tissue: Brain

520
Synthetic α5β1 integrin ligand PHSRN is proangiogenic and neuroprotective in cerebral ischemic stroke

Cheng-Chun Wu, Liang-Chao Wang, Yu-Tin Su, Wei-Yen Wie, Kuen-Jer Tsai

Biomaterials (Elsevier) Taiwan, 11 September 2018

Biological Materials

Key words: Stroke, Fibronectin, PHSRN, α5β1, Angiogensis, Neurogenesis, VEGF

Organism: Rat

Tissue: Brain

521
Factor Xa inhibition by rivaroxaban regulates fibrogenesis in human atrialfibroblasts with modulation of nitric oxide synthesis and calciumhomeostasis

Cheng-Chih Chung, Yung-Kuo Lin, Yao-Chang Chen, Yu-Hsun Kao, Yung-Hsin Yeh, Yi-Jen Chen

Journal of Molecular and Cellular Cardiology (Elsevier) Taiwan, 10 September 2018

Physiology

Key words: Fibroblasts, Fibrosis, Rivaroxaban, Protease-activated receptor, Atrial fibrillation, Stroke

Organism: Rat

Tissue: Heart

Pathological State: Fibrosis

522
Phenethyl Isothiocyanate Inhibits In Vivo Growth of Xenograft Tumors of Human Glioblastoma Cells

Yu-Cheng Chou, Meng-Ya Chang, Hsu-Tung Lee, Chiung-Chyi Shen, Tomor Harnod, Yea-Jiuan Liang, Rick Sai-Chuen Wu, Kuang-Chi Lai, Fei-Ting Hsu, Jing-Gung Chung

Molecules (MDPI) Taiwan, 10 September 2018

Oncology

Key words: phenethyl isothiocyanate, apoptosis, xenograft, caspase, glioblastoma

Organism: Mouse

Tissue: Liver, Xenograft Tumor

Pathological State: Cancer

523
Androgen receptor expression inversely correlates with immune cell infiltration in human epidermal growth factor receptor 2–positive breast cancer

Johan M. van Rooijen, Si-Qi Qiu, Hetty Timmer-Bosscha, Bert van der Vegt, James E. Boers, Carolien P. Schröder, Elisabeth G.E. de Vries

European Journal of Cancer (Elsevier) The Netherlands, China, 09 September 2018

Oncology

Key words: Androgen receptor expression, HER2-positive metastatic breast cancer, Immune cell infiltration, Trastuzumab resistance

Organism: Human

Tissue: Breast

Pathological State: Cancer

524
TLR7 agonist attenuates acetylcholine‐induced, Ca2+‐dependent ionic currents in swine tracheal submucosal gland cells

Shunichi Gamo, Tsutomu Tamada, Koji Murakami, Soshi Muramatsu, Hidemi Aritake, Masayuki Nara, Itsuro Kazama, Tatsuma Okazaki, Hisatoshi Sugiura, Masakazu Ichinose

Experimental Physiology (Wiley) Japan, 08 September 2018

Physiology

Key words: CaCC, COPD, hypersecretion, R837, submucosal glands

Organism: Pig, Human

Tissue: Lung, Spleen

525
Inhibitory control of prefrontal cortex by the claustrum

Jesse Jackson, Mahesh M. Karnani, Boris V. Zemelman, Denis Burdakov, Albert K. Lee

Neuron (Cell Press) USA, UK, Canada, 05 September 2018

Neuroscience

Key words: claustrum prefrontal NPY PV neocortex feed-forward inhibition microcircuit neurogliaform cell somatostatin interneuron VIP

Organism: Mouse

Tissue: Brain

526
Oxidized Low-Density Lipoprotein-Deteriorated Psoriasis Is Associated with the Upregulation of Lox-1 Receptor and Il-23 Expression In Vivo and In Vitro

Chun-Ming Shih, Chien-Yu Huang, Kuo-Hsien Wang, Chun-Yao Huang, Po-Li Wei, Yu-Jia Chang, Chi-Kun Hsieh, Kuan-Ting Liu, Ai-Wei Lee

International Journal of Molecular Sciences (MDPI) Taiwan, 03 September 2018

Dermatology

Key words: oxLDL, LOX-1, psoriasis

Organism: Mouse

Tissue: Skin

Pathological State: Psoriasis

527
Amentoflavone Inhibits Hepatocellular Carcinoma Progression Through Blockage of ERK/NF-ĸB Activation

Kun-Ching Lee, Wei-Ting Chen, Yu-Chang Liu, Song-Shei Lin, Fei-Ting Hsu

in vivo: international journal of experimental and clinical pathophysiology and drug research (International Institute of Anticancer Research) Taiwan, 01 September 2018

Oncology

Key words: Amentoflavone, hepatocellular carcinoma, extracellular signal-regulated kinase, nuclear factor-kappaB, bioluminescence imaging.

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

528
Enhanced Sternal Healing via Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel

Masafumi Shibata, Gen Takagi, Mitsuhiro Kudo, Jiro Kurita, Yoko Kawamoto, Yasuo Miyagi, Mikimoto Kanazashi, Takashi Sakatani, Zenya Naito, Yasuhiko Tabata, Masaaki Miyamoto, and Takashi Nitta

Tissue Engineering Part A (Mary Ann Liebert Inc.) Japan, 01 September 2018

Regenerative Medicine

Organism: Rabbit

Tissue: Bone

529
The tree shrew cerebellum atlas: Systematic nomenclature, neurochemical characterization and afferent projections

Rong‐Jun Ni Zhao‐Huan Huang Peng‐Hao Luo Xiao‐Hong Ma Tao Li Jiang‐Ning Zhou

Journal of Comparative Neurology (Wiley) China, 29 August 2018

Neuroscience

Key words: cerebellar nuclei, lobule fissure, inferior olive, Purkinje cell, calbindin, RRID: AB_476894

Organism: Tree Shrew

Tissue: Brain

530
Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction

Po-Hung Hsu, Ya-Tin Lin, Yi-Hsiu Chung, Kun-Ju Lin, Liang-Yo Yang, Tzu-Chen Yen and Hao-Li Liu

Scientific Reports (Nature) Taiwan, 27 August 2018

Neuroscience

Key words: Alzheimer's diseas, eBiomedical engineering ,Blood–brain barrier, Drug delivery, Translational research, GSK-3, Amyloid-Beta Plaque

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

531
NFAT5 isoform C controls biomechanical stress responses of vascular smooth muscle cells

Maren Zappe, Anja Feldner, Caroline Arnold, Carsten Sticht, Markus Hecker and Thomas Korff

Frontiers in Physiology (Frontiers Media S.A.) Germany, 23 August 2018

Cardiology

Key words: NFAT5, TonEBP, hypertension, transcriptional regulation, vascular smooth muscle cells, wall stress

Organism: Human

Cell Line: Human arterial smooth muscle cells (HUASMCs)

532
Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats

Shang-Cheng Huang, Tzu-Ling Li, Yen-Hsien Lee, Yu-Wen E. Dai, Yu-Chun Chen Ling-Ling Hwang

Scientific Reports (Nature) Taiwan, 23 August 2018

Cardiology

Key words: Hypertension, Hypothalamus

Organism: Rat

Tissue: Brain

533
Photoperiodic Flower Mimicking Metallic Nanoparticles for Image-Guided Medicine Applications

S Cho, B Lee, W Park, X Huang, DH Kim

ACS Applied Materials and Interfaces (ACS Publications) USA, 22 August 2018

Radiotherapy

Key words: metallic nanoparticles, radiosensitizers, image-guided radiotherapy, radiation, cancer therapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

534
Optimization of an Anti-NMDA Receptor Autoantibody Diagnostic Bioassay

NC Chiu, YJ Lin, RF Tzang, YS Li, HJ Lin, S Das, CG Chen, CC Chen, K Hsu

Circulation (NCBI) Taiwan, Denmark, Sweden, 22 August 2018

Neuroscience

Key words: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, autoantibody (autoAb), autoimmune encephalitis, schizophrenia, diagnostic test, fluorescein isothiocyanate (FITC), Alexa Fluor 488, antigen (Ag)

Organism: Human

Pathological State: Encephalitis

535
Lack of DNA damage response at low radiation doses in adult stem cells contributes to organ dysfunction

Peter W Nagle, Nynke A Hosper, Lara Barazzuol, Anne L Jellema, Mirjam Baanstra, Marc-Jan van Goethem, Sytze Brandenburg, Ulrich Giesen, Johannes A. Langendijk, Peter van Luijk and Rob P Coppes

Clinical Cancer Research (AACR Publications) The Netherlands, 22 August 2018

Oncology

Key words: DNA Damage, Radiation, Stem Cells, Organ Dysfunction, Radiotherapy

Organism: Mouse

Tissue: Thyroid, Salivary Gland

536
Modified Methacrylate Hydrogels Improve Tissue Repair after Spinal Cord Injury

Aleš Hejčl OrcID, Jiří Růžička, Kristýna Kekulová 1OrcID, Barbora Svobodová, Vladimír Proks OrcID, Hana Macková , Kateřina Jiránková , Kristýna Kárová , Lucia Machová Urdziková, Šárka Kubinová, Jiří Cihlář , Daniel Horák and Pavla Jendelová

International Journal of Molecular Sciences (MDPI) Czech Republic, 22 August 2018

Regenerative Medicine

Key words: spinal cord injury, hydrogel, connective tissue, neurofilaments, locomotor test, plantar test

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

537
Striatal Microstimulation Induces Persistent and Repetitive Negative Decision-Making Predicted by Striatal Beta-Band Oscillation

Ken-ichi Amemori, Satoko Amemori,Daniel J. Gibson and Ann M. Graybie

Neuron (Cell Press) USA, 22 August 2018

Neuroscience

Key words: approach-avoidance conflict, basal ganglia, beta oscillation, caudate nucleus, cost-benefit decisions, emotion, macaque, motivation, primate, value judgment

Organism: Pig, Human

Tissue: Brain

538
Secreted products of oral bacteria and biofilms impede mineralization of apical papilla stem cells in TLR-, species-, and culture-dependent fashion

Xenos Petridis,Luc W. M. van der Sluis,1 René J. B. Dijkstra,1 Marja G. L. Brinker, Henny C. van der Mei,and Martin C. Harmsen

Scientific Reports (Nature) The Netherlands, 21 August 2018

Immunology, Microbiology

Key words: Mesenchymal stem cells, Oral diseases, biofilms

Organism: Human

Cell Line: SCAP (Stem cells from apical papilla)

539
Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature

Tej Pratap Singh,Pablo A. Vieyra-Garcia,Karin Wagner,Josef Penninger,Peter Wolf

Cell Death & Disease (Nature) Austria, 06 August 2018

Oncology

Key words: Cbl-b deficiency, UVB, skin damage, inflammation, gene signature

Organism: Mouse, Human

Tissue: Skin

540
Expression and modulation of S100A4 protein by human mast cells

Rossana Domenis, David Pilutti, Maria Orsaria, Stefania Marzinotto, Veronica Candotti, Giulia Bosisio, Michela Bulfoni, Maria Elisabetta Ruaro, Carla Di Loreto, Vincenzo Della Mea, Eleonora Toffoletti, Ambrogio P.Londero, Laura Mariuzzi, Giorgia Gri

Cellular Immunology (Elsevier) Italy, 04 August 2018

Immunology

Key words: Immunofluorescence Tryptase Metalloproteinase Mast cells biology siRNA

Organism: Human

Tissue: Skin

Pathological State: Bladder Cyst, Crohn's Disease, Cancer

541
Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine

Chang‐Bin Liu De‐Gang Yang Xin Zhang Wen‐Hao Zhang Da‐Peng Li Chao Zhang Chuan Qin Liang‐Jie Du Jun Li Feng Gao Jie Zhang Zhen‐Tao Zuo Ming‐Liang Yang Jian‐Jun Li

CNS Neuroscience and Therapeutics (Wiley) China, 03 August 2018

Neuroscience

Key words: canine model, diffusion tensor imaging, gray matter, pathological degeneration, spinal cord injury, white matter

Organism: Dog

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

542
Crumpled Aluminum Hydroxide Nanostructures as a Microenvironment Dysregulation Agent for Cancer Treatment

MI Lerner, G Mikhaylov, AA Tsukanov, Aleksandr S. Lozhkomoev, Elazar Gutmanas, Irena Gotman, Andreja Bratovs, Vito Turk‡ Boris Turk, Sergey G. Psakhye, and Olga Vasiljeva

Nano Letters (ACS Publications) Russia, Israel, Slovenia, 02 August 2018

Nanomedicine

Key words: aluminum hydroxide, cancer treatment, Crumpled nanosheets, ion balance, molecular dynamics simulation, tumor microenvironment

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

543
Plk1 overexpression suppresses tumor development by inducing chromosomal instability

Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañés, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres and Rocío Sotillo

Nature Communications (Nature) Spain, Germany, UK, 01 August 2018

Oncology

Key words: Cancer, Cell biology

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

544
SCID/NOD mice model for 5-FU induced intestinal mucositis: Safety and effects of probiotics as therapy

LawrenceHuangabJen-ShiuChiang ChiaucMei-LienChengcWai-TaoChanaChuen-BinJiangadSzu-WenChangaChun-YanYeungaeHung-ChangLee

Pediatrics and Neonatology (Elsevier) Taiwan, 26 July 2018

Gastroenterology

Key words: SCID, cytokines, fluorouracil, mucositis, probiotics

Organism: Mouse

Tissue: Small Intestine

Pathological State: Diarrhea

545
Trehalose to cryopreserve human pluripotent stem cells

Aikaterini Ntaia , Alberto La Spadab , Pasquale De Blasioa , Ida Biunno

Stem Cell Research (Elsevier) Italy, 25 July 2018

Stem Cell Research

Key words: Cryopreservation, Trehalose, Pluripotent stem cells

Organism: Human

Cell Line: hESCs, lt-NES, hiPSCs

546
Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells

YT Wu, KT Chi, YW Lan, JC Chan, YS Ma, YH Wie

Free Radical Research (Taylor and Francis) Taiwan, 23 July 2018

Stem Cell Research

Key words: Adipogenesis, antioxidant defence, human mesenchymal stem cells, insulin resistance, mitochondrial bioenergetics, Sirt3

Organism: Human

Cell Line: adiposederived human mesenchymal stem cells

547
Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells

Anja Weber,Helmut Klocker,Herbert Oberacher,Erich Gnaiger,Hannes Neuwirt,Natalie Sampson and Iris E. Eder

International Journal of Molecular Sciences (MDPI) Austria, 21 July 2018

Oncology

Key words: Na+-dicarboxylate transporter, acidic tumor microenvironment, mitochondria, oxidative phosphorylation, prostate cancer, succinate

Organism: Human

Pathological State: Cancer

Cell Line: LNCaP, PC-3 (prostate cancer cell lines)

548
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Mario Mauthe, Idil Orhon, Cecilia Rocchi, Xingdong Zhou, Morten Luhr, Kerst-Jan Hijlkema, Robert P. Coppes, Nikolai Engedal, Muriel Mari and Fulvio Reggiori

Autophagy (Taylor and Francis) The Netherlands, 20 July 2018

Cell Biology

Key words: Autophagy, Golgi, bafilomycin A1, degradative compartments, fusion, lysosomal degradation, lysosomal inhibitors

Organism: Human

Pathological State: Cancer

Cell Line: U2OS (Osteosarcoma cell line), HeLa cells

549
Prognostic and predictive values of immune infiltrate in patients with head and neck squamous cell carcinoma

Xue-MeiZhang Ling-JunSong JuanShenHao YueYa-QinHanChen LingYangShi YunLiuJia WenDengYue JiangGuo HuiFu

Human Pathology (Elsevier) China, 20 July 2018

Oncology

Key words: Head and Neck Squamous Cell Carcinoma, Immunoscore, Prognosis and Predictive, Tumor Infiltrating Lymphocytes

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

550
Significant therapeutic effects of adult human multipotent neural cells on spinal cord injury

KH Lee, HJ Pyeon, H Nam, JS Won, JY Hwang, KA Lee, JY Yeon, SC Hong, DH Nam, K Lee, SH Lee, KM Joo

Stem Cell Research (Elsevier) South Korea, 19 July 2018

Stem Cell Research

Key words: Spinal cord injuries, Adult stem cells, Neural stem cells, Microvasculature, Chemokine1

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

551
Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition

Ján Remšík Lucia Binó Zuzana Kahounová Gvantsa Kharaishvili Šárka Šimečková Radek Fedr Tereza Kučírková Sára Lenárt Ximena Maria Muresan Eva Slabáková

Carcinogenesis (Oxford University Press) Czech Republic, 16 July 2018

Oncology

Key words: phenotype, cancer, carcinoma, epithelium, heterogeneity, antigens, cell lines, membrane glycoproteins, breast, neoplasms, prostate, transcription factor, prostate cancer, carcinogenesis, e-cadherin, tumor progression, epithelial to mesenchymal transition, molecular targeted therapy, tumor cells, malignant

Organism: Human

Tissue: Prostate, Breast

Pathological State: Cancer

552
Enhancement of chondrogenesis of adipose-derived stem cells in HA-PNIPAAm-CL hydrogel for cartilage regeneration in rabbits

Chau-Zen Wang,Rajalakshmanan Eswaramoorthy,Tzu-Hsiang Lin,Chung-Hwan Chen,Yin-Chih Fu,Chih-Kuang Wang,Shun-Cheng Wu,Gwo-Jaw Wang, Je-Ken Chang,corresponding author Mei-Ling Ho

Scientific Reports (Nature) Taiwan, 12 July 2018

Regenerative Medicine

Key words: Biomaterials, Regeneration, hydrogel, cartilage

Organism: Rabbit

Cell Line: rADSCs (rabbit adipose-derived stem cells )

553
Expression of serine peptidase inhibitor Kunitz type 1 in differentiated thyroid cancer

Chien-Liang LiuPo-Sheng YangMing-Nan ChienYuan-Ching ChangChi-Hsin LinShih-Ping Cheng

Histochemistry and Cell Biology (Springer) Taiwan, 10 July 2018

Oncology

Key words: Serine protease inhibitor , Hepatocyte growth factor , Thyroid cancer Invasion

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

554
Synergistic Cross‐Talk of Hedgehog and Interleukin‐6 Signaling Drives Growth of Basal Cell Carcinoma

Christina Sternberg Wolfgang Gruber Markus Eberl Suzana Tesanovic Manuela Stadler Dominik P. Elmer Michaela Schlederer Sandra Grund Simone Roos

International Journal of Cancer (Wiley) Austria, 10 July 2018

Oncology

Key words: GLI signaling , GLI transcription factors , STAT transcription factors, basal cell carcinoma , hedgehog, interleukin-6 signaling

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

555
TERT Promoter Mutations in Solitary Fibrous Tumor

Elizabeth G Demicco Khalida Wani Davis Ingram Michael Wagner Robert G. Maki Anthony Rizzo Alan Meeker Alexander J Lazar Wei‐Lien Wang

HistoPathology (Wiley) USA, 09 July 2018

Oncology

Key words: ATRX , DAXX , metastasis, outcome, prognosis, risk assessment, solitary fibrous tumour, telomerase reverse transcriptase

Organism: Human

Pathological State: Cancer

556
Development of a Novel Orthogonal Double Gradient for High‐Throughput Screening of Mesenchymal Stem Cells–Materials Interaction

Qihui Zhou Lu Ge Carlos F. Guimarães Philipp T. Kühn Liangliang Yang Patrick van Rijn

Advanced Materials Interfaces (Wiley) The Netherlands, 04 July 2018

Biological Materials

Key words: high‐throughput screening, orthogonal double gradient, stem cell, stiffness, wettability

Organism: Human

Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)

557
Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo

Yi‐Shih Ma Jen‐Jyh Lin Chin‐Chung Lin Jin‐Cherng Lien Shu‐Fen Peng Ming‐Jen Fan Fei‐Ting Hsu Jing‐Gung Chung

Environmental Toxicology (Wiley) Taiwan, 04 July 2018

Oncology

Key words: benzyl isothiocyanate, human brain glioblastoma multiforme GBM 8401 cell, in vivo, nude mice, xenograft tumor

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

558
Antrodia cinnamomea produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway

Tsung-TengHuang Ying-WeiLan Yun-FeiKo Chuan-MuChen Hsin-ChihLaijkDavid M.Ojcius JanMartel John D.Young Kowit-YuChong

Journal of Ethnopharmacology (Elsevier) Taiwan, 28 June 2018

Cell Biology

Key words: Antrodia cinnamomea, Anti-angiogenic activity, Endothelial cells, VEGFR2, STAT3

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

559
Dynamics of tissue ingrowth in SIKVAV-modified highly superporous PHEMA scaffolds with oriented pores after bridging a spinal cord transection

Aleš Hejčl, Jiří Růžička Vladimír Proks, Hana Macková, Šárka Kubinová Dmitry Tukmachev,Jiří Cihlář Daniel Horák Pavla Jendelová

Journal of Materials Science: Materials in Medicine (Springer) Czech Republic, 25 June 2018

Regenerative Medicine

Key words: tissue ingrowth, SIKVAV, superporous, PHEMA scaffolds, oriented pores, spinal cord injury, mesenchymal stem cells (MSCs)

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

560
Neuroplastic change of cytoskeleton in inferior colliculus after auditory deafferentation

Jae JoonHanaHo SunLeebcMin-HyunPark

Hearing Research (Elsevier) South Korea, 23 June 2018

Neuroscience

Key words: Auditory deafferentation, Deafness, SMI-32, Neurofilament heavy chain, Inferior colliculus

Organism: Rat

Tissue: Brain

Pathological State: Deafness

561
Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes

Guadalupe Navarro, Camille Allard, Jamie J. Morford, Weiwei Xu, Suhuan Liu, Adrien J.R. Molinas, Sierra M. Butcher, Nicholas H.F. Fine, Manuel Blandino-Rosano, Venkata N. Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A. Jacobson, Prasad V. Katakam,David J. Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok,and Franck Mauvais-Jarvis

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 21 June 2018

Oncology

Key words: Beta cells, Diabetes, Endocrinology, Metabolism, Sex hormones

Organism: Mouse

Tissue: Pancreas

Pathological State: Diabetes

562
Afatinib restrains K-RAS–driven lung tumorigenesis

Herwig P. Moll, Klemens Pranz, Monica Musteanu, Beatrice Grabner, Natascha Hruschka, Julian Mohrherr

Science Translational Medicine (American Association for the Advancement of Science) Austria, 20 June 2018

Oncology

Key words: Afatinib, K-RAS, lung cancer, pan-ERBB, tyrosine kinase inhibitors

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

563
Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis

Kumud R.Poudel MinnaRoh-Johnson AllenSu ThuongHo HarithaMathsyaraja SarahAnderson William M.Grady Cecilia B.Moens MaraliceConacci-Sorrell Robert N.Eisenman

Developmental Cell (Cell Press) USA, 18 June 2018

Oncology

Key words: BAR domain, PTEN, Rac1, TIAM1, cell migration, endocytosis, endophilin, membrane remodeling, metastasis

Organism: Mouse

Tissue: Whole Organism

Pathological State: Cancer

564
Endothelial colony forming cells from human umbilical cord blood improved severe erectile dysfunction in obese type II diabetic rats

Abrar Al-Mahmood Siddiqueea , P. Ganesan Adaikana, , Lang Chu Laua , Baharudin Bin Saida , Mark Chongb , Jerry Chanc , Swee Hin Teoh

Life Science (Elsevier) Singapore, 18 June 2018

Reproductive Medicine

Key words: Severe erectile dysfunction, Human endothelial colony forming cells, Intracavernosal pressure, Zucker diabetic fatty rats

Organism: Rat

Tissue: Penis

Pathological State: Erectile dysfunction

565
Quantitative measurement of breast carcinoma fibrosis for the prediction in the risk of bone metastasis

Chong Sun, Bin Wang, Jianmin Li, Junjie Shangguan, Matteo Figini, Kang Zhou, Liang Pan, Quanhong Ma, Zhuoli Zhang

American Journal of Translational Research (e-Century Publishing Corporation) China, 15 June 2018

Oncology

Key words: Invasive breast carcinoma, bone metastasis, collagen deposition, early prediction

Organism: Human

Tissue: Breast

Pathological State: Cancer

566
Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

Sander C Steenbeek, Thang V Pham, Joep de Ligt, Anoek Zomer, Jaco C Knol, Sander R Piersma, Tim Schelfhorst, Rick Huisjes, Raymond M Schiffelers, Edwin Cuppen, Connie R Jimenez, Jacco van Rheenen

EMBO Journal (EMBO press) The Netherlands, 15 June 2018

Oncology

Key words: Cre‐LoxP, extracellular vesicles, intratumoral heterogeneity, intravital microscopy, signaling networks

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

567
Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts

Tanja Niedermair, Stephan Schirner, Raphael Seebröker, Rainer H. Straub, Susanne Grässel

Scientific Reports (Nature) Germany, 15 June 2018

Physiology

Key words: Substance P, bone remodeling, osteoblasts, osteoclasts, Bone, Mechanisms of disease

Organism: Mouse

Cell Line: Osteoclast, Osteoblast

568
Synergistic Antitumor Effect of Oligogalacturonides and Cisplatin on Human Lung Cancer A549 Cells

Cian-Song Huang, Ai-Chun Huang, Ping-Hsiu Huang, Diana Lo, Yuh-Tai Wang, Ming-Chang Wu

International Journal of Molecular Sciences (MDPI) Taiwan, 14 June 2018

Oncology

Key words: adjuvant therapy, cisplatin, oligogalacturonides, synergistic effect

Organism: Human

Pathological State: Cancer

Cell Line: A549 (Lung carcinoma cells)

569
Nerve Growth Factor (NGF)—Receptor Survival Axis in Head and Neck Squamous Cell Carcinoma

József Dudás, Wolfgang Dietl, Angela Romani, Susanne Reinold, Rudolf Glueckert, Anneliese Schrott-Fischer, Daniel Dejaco, Lejo Johnson Chacko, Raphaela Tuertscher, Volker Hans Schartinger, Herbert Riechelmann

International Journal of Molecular Sciences (MDPI) Austria, 14 June 2018

Oncology

Key words: TissueFaxs, cell cycle arrest, cytokeratin, necrosis

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

570
Breast Cancer Histological Image Classification Using Fine-Tuned Deep Network Fusion

A Mahbod, I Ellinger, R Ecker, Ö Smedby, C Wang

(Springer) , 06 June 2018

Key words: Breast cancer Histological images Classification Deep learning

571
Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

Somayyeh Hamzei Taj, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Alessandra Quarta, Jelle Praet, Annemie Van der Linden, Peter Ponsaerts, Mathias Hoehn

Journal of Neuroinflammation (Springer) Germany, 04 June 2018

Immunology

Key words: Interleukin 13, Mesenchymal stem cells, Microglia/macrophage polarization, Neuroinflammation, Stroke

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

572
Novel Conducting and Biodegradable Copolymers with Noncytotoxic Properties toward Embryonic Stem Cells

Aruã C. da Silva, Ana Teresa S. Semeano, André H. B. Dourado, Henning Ulrich, Susana I. Cordoba de Torresi

ACS OMEGA (ACS Publications) Brazil, 31 May 2018

Stem Cell Research

Key words: Cell and Molecular biology, Conducting polymers, Environmental biology, Polyesters

Organism: Human

Cell Line: Human embryonic stem cells (hESCs)

573
Hierarchical Multiplexing Nanodroplets for Imaging-Guided Cancer Radiotherapy via DNA Damage Enhancement and Concomitant DNA Repair Prevention

Wei Jiang, Quan Li, Liang Xiao, Jiaxiang Dou, Yi Liu, Wenhao Yu, Yinchu Ma, Xiaoqiu Li, Ye-Zi You, Zhuting Tong, Hang Liu, Hui Liang, Ligong Lu, Xiaoding Xu, Yandan Yao, Guoqing Zhang, Yucai Wang, and Jun Wang

ACS NANO (ACS Publications) China, 29 May 2018

Nanomedicine

Key words: cancer radiotherapy, DNA damage and repair, hierarchical nanostructure, multimodal imaging, tumor hypoxia

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

574
Acellular vascular matrix grafts from human placenta chorion: Impact of ECM preservation on graft characteristics, protein composition and in vivo performance

Karl H. Schneider, Marjan Enayati, Christian Grasl, Ingrid Walter, Lubos Budinsky, Gabriel Zebic, Christoph Kaun, Anja Wagner, Klaus Kratochwill, Heinz Redl, Andreas Teuschl, Bruno K. Podesser, Helga Bergmeister

Biomaterials (Elsevier) Austria, 29 May 2018

Regenerative Medicine

Key words: Decellularized matrix, Human placenta, Small diameter vascular grafts, Cell migration, Biocompatibility

Organism: Human

Tissue: Placenta

575
Identification of galectin-3 as an autoantigen in patients with IgG4-related disease

Cory A. Perugino, Sultan B. AlSalem, Hamid Mattoo, Emanuel Della-Torre, Vinay Mahajan, Gayathri Ganesh, Hugues Allard-Chamard, Zachary Wallace, Sydney B. Montesi, Johannes Kreuzer, Wilhelm Haas, John H. Stone, Shiv Pillai

Journal of Allergy and Clinical Immunology (Elsevier) UK, USA, Italy, 29 May 2018

Immunology

Key words: IgG4-related disease, plasmablast, autoantigen, galectin-3, autoantibody

Organism: Human

Tissue: Pancreas

Pathological State: IgG4-Related Disease

576
Allocation of Interferon Gamma mRNA Positive Cells in Caecum Hallmarks a Protective Trait Against Histomonosis

Fana Alem Kidane, Taniya Mitra, Patricia Wernsdorf, Michael Hess, Dieter Liebhart

Frontiers in Immunology (Frontiers Media S.A.) Austria, 28 May 2018

Immunology

Key words: Histomonas meleagridis, histomonosis, image analysis, immunofluorescence, in situ hybridization, interferon gamma, interleukin-13, vaccination

Organism: Turkey, Chicken

Tissue: Small Intestine, Liver, Spleen

Pathological State: Parasitic Infection

577
The overexpression of Fra1 disorders the inflammatory cytokine secretion by mTEC of myasthenia gravis thymus

Q.‐R. Li W.‐P. Ni N.‐J. Lei J.‐Y. Yang X.‐Y. Xuan P.‐P. Liu G.‐M. Gong F. Yan Y.‐S. Feng R. Zhao Y. Du

Scandinavian journal of Immunology (Blackwell Publishing Inc.) China, 28 May 2018

Neuroscience

Key words: Fos-related antigen-1, inflammatory cytokine, medulla thymic epithelial cells, myasthenia gravis

Organism: Human

Tissue: Thymus

Pathological State: Myasthenia Gravis

578
Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke

Ewelina Kurtys Cindy Casteels Caroline C. Real Ulrich L. M. Eisel J. Martin Verkuyl Laus M. Broersen Hans C. Klein Rudi A. J. O. Dierckx Janine Doorduin Erik F. J. de Vries

CNS Neuroscience and Therapeutics (Wiley) The Netherlands, 27 May 2018

Neuroscience

Key words: PET imaging, neuroinflammation, nutrition, photothrombotic stroke

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

579
Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI-PEG20 treatment in CCA cell lines

Somphon Roeksomtawin, Panida Navasumrit, Somchamai Waraprasit, Varabhorn Parnlob, Thaniya Sricharunrat, Vajarabhongsa Bhudhisawasdi, Niramol Savaraj, Mathuros Ruchirawat

Oncology Letters (Spandidos Publications) Thailand, 24 May 2018

Oncology

Key words: Ki-67, arginine deprivation, argininosuccinate synthetase, cholangiocarcinoma, pegylated arginine deiminase

Organism: Human

Tissue: Liver

Pathological State: Cancer

Cell Line: Cholangiocarcinoma cell lines (RmCCA-1 and HuCCA), human fibroblast cell line (BJ-1)

580
Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway

Zhen Yang Cui, Soo Jung Park, Eunbi Jo, In-Hu Hwang, Kyung-Bok Lee, Sung-Woo Kim, Dae Joon Kim, Jong Chun Joo, Seok Hoon Hong, Min-Goo Lee and Ik-Soon Jang

Cell Death Discovery (Nature) South Korea, USA, 23 May 2018

Oncology

Organism: Human

Pathological State: Cancer

Cell Line: SKOV-3 cells

581
BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling

Yueh-Hua Chung, Ying-Hsien Huang, Tien-Huei Chu, Chun-Lin Chen, Pey-Ru Lin, Shih-Chung Huang, Deng-Chyang Wu, Chao-Cheng Huang, Tsung-Hui Hu, Ying-Hsien Kao and Ming-Hong Tai

Laboratory Investigation (Nature) Taiwan, 22 May 2018

Hepathology

Key words: BMP-2, liver fibrosis, TGF-β1 signaling

Organism: Human

Tissue: Liver

Pathological State: Hepatitis, Liver Cirrhosis

582
Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis

Henning Ulrich, Mariusz Z. Ratajczak, Gabriela Schneider, Elena Adinolfi, Elisa Orioli, Enéas G. Ferrazoli, Talita Glaser, Juliana Corrêa-Velloso, Poliana C. M. Martins, Fernanda Coutinho, Ana P. J. Santos, Micheli M. Pillat, Ulrich Sack, Claudiana Lameu

Frontiers in Pharmacology (Frontiers Media S.A.) Brazil, 18 May 2018

Oncology

Key words: bone marrow, bradykinin, metastasis, neuroblastoma, purinergic system

Organism: Human

Pathological State: Cancer

Cell Line: CHP-100 cells

583
Lactobacillus casei Variety rhamnosus Probiotic Preventively Attenuates 5-Fluorouracil/Oxaliplatin-Induced Intestinal Injury in a Syngeneic Colorectal Cancer Model

Ching-Wei Chang, Chia-Yuan Liu, Hung-Chang Lee, Yen-Hua Huang, Li-Hui Li, Jen-Shiu Chiang Chiau, Tsang-En Wang, Cheng-Hsin Chu, Shou-Chuan Shih, Tung-Hu Tsai, Yu-Jen Chen

Frontiers in Microbiology (Frontiers Media S.A.) Taiwan, 15 May 2018

Oncology

Key words: FOLFOX, Lactobacillus, apoptosis, gut microbiota, intestinal mucositis

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

584
Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice

Zheng-HuaWangZhan-ShengHu

Biomedicine and Pharmacotherapy (Elsevier) China, 14 May 2018

Oncology

Key words: Gastric cancer, Catalpol, Migration, Apoptosis and ROS, DDP

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

585
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

Amelie Griveau, GiorgioS eano, Samuel J. Shelton, Robert Kupp, Arman Jahangiri, Kirsten Obernier, Shanmugarajan Krishnan, Olle R. Lindberg, Tracy J. Yuen, An-Chi Tien, Jennifer K.Sabo, Nancy Wang, Ivy Chen, Jona sKloepper, Louis Larrouquere, Mitrajit Ghosh, Itay Tirosh, Emmanuelle Huillard, Arturo Alvarez-Buylla, Michael C. Oldham, Anders I. Persson, William A. Weiss, Tracy T. Batchelor, Anat Stemmer-Rachamimov, Mario L.Suvà, Joanna J. Phillips, Manish K .Aghi, Shwetal Mehta, Rakesh K. Jain, David H. Rowitch

Cancer Cell (Cell Press) USA, 14 May 2018

Oncology

Key words: Olig2, Wnt, angiogenesis, astrocyte, blood-brain barrier, glioma, invasiveness, oligodendrocyte precursor, p53, vessel co-option

Organism: Human, Mouse

Tissue: Brain, Xenograft Tumor

Pathological State: Cancer

586
Hematological findings in non-treated and gamma-irradiated mice deficient for MIC-1/GDF15.

M. HOFER, Z. HOFEROVÁ, J. REMŠÍK, M. NOVÁKOVÁ, J. PROCHÁZKOVÁ, R. FEDR, J. KOHOUTEK, L. DUŠEK, A. HAMPL, K. SOUČEK

Physiological Research (BioMed Central) Czech Republic, 10 May 2018

Hematology

Key words: GDF15 knockout mice, hematopoiesis, ionizing radiation, stress-induced cytokine

Organism: Mouse

Tissue: Spleen, Bone

587
DNA damage predicts prognosis and treatment response in colorectal liver metastases superior to immunogenic cell death and T cells

Johannes Laengle, Judith Stift, Agnes Bilecz, Brigitte Wolf, Andrea Beer, Balazs Hegedus, Stefan Stremitzer, Patrick Starlinger, Dietmar Tamandl, Dietmar Pils, Michael Bergmann

Theranostics (Ivyspring International Publisher) Austria, 10 May 2018

Oncology

Key words: DNA damage, calreticulin, immunogenic cell death, colorectal liver metastases

Organism: Human

Tissue: Colon

Pathological State: Cancer

588
Regorafenib inhibits tumor progression through suppression of ERK/NF-κB activation in hepatocellular carcinoma bearing mice

Mao-Chi Weng, Mei-Hui Wang, Jai-Jen Tsai, Yu-Cheng Kuo, Yu-Chang Liu, Fei-Ting Hsu, Hsin-Ell Wang

Bioscience Reports (Kluwer Academic Publishers) Taiwan, 05 May 2018

Oncology

Key words: Bioluminescence imaging, Regorafenib, apoptosis, hepatocellular carcinoma, nuclear factor kappaB

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

589
Effects of chitosan and chitosan N-acetylcysteine solutions on conjunctival epithelial cells

N Schuerer, E Stein, A Inic-Kanada, E Ghasemian, Marijana Stojanovic, Jacqueline Montanaro, Nora Bintner, Christine Hohenadl, Robert Sachsenhofer, Talin Barisani-Asenbauera

Journal of EuCornea (Elsevier) Austria, Serbia, 02 May 2018

Ophthalmology

Key words: Chitosan Chitosan-N-acetylcysteine Uptake Conjunctival epithelial cells Drug delivery

Organism: Guinea Pig

Tissue: Eye

590
Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor‐suppressing phenotype

Hong‐Tai Tzeng Ching‐Chin Su Chih‐Peng Chang Wu‐Wei Lai Wu‐Chou Su Yi‐Ching Wang

International journal of cancer (Wiley) Taiwan, 01 May 2018

Oncology

Key words: Rab37, ST2, exocytosis, macrophage, tumor microenvironment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

591
Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1

Aline Yen LingWanga Charles Yuen YungLoh Shyi-JouChen Huang-KaiKao Cheng-HungLin Sheng-HaoChuang Chin-MingLee Huey-KangSytwu Fu-ChanWei

Molecular Immunology (Elsevier) Taiwan, 23 April 2018

Immunology

Key words: Allograft tolerance, B lymphocyte-induced maturation protein, T cells

Organism: Mouse

Tissue: Skin

Pathological State: Organ Transplantation

592
Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the Akt‑GSK3β and MAPK/ERK signaling cascades

Xiaona Wang Yanyan Zhu Lili Zhu Xinhuan Chen Yanyan Xu Yafei Zhao Yingzhe Shao Feng Li Yanan Jiang Jing Lu Youtian Huang Xiaobin Chang Juan Zhang Xiang Li Kangdong Liu Mingyao Zhao Ziming Dong Jimin Zhao

Oncology Reports (Demetrios A. Spandidos Ed. and Pub.) China, 23 April 2018

Oncology

Key words: Eupatilin, human esophageal cancer, TE1 cells, Akt‑GSK3β, MAPK/ERK

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

593
IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury

Wei-Yu Chen, Jenq-Lin Yang, Yi-Hsiu Wu, Lung-Chih Li, Ru-Fang Li, Ya-Ting Chang, Lo-Hsin Dai, Wan-Chen Wang, Ya-Jen Chang

Experimental and Molecular Medicine (Nature) Taiwan, 20 April 2018

Nephrology

Key words: IL-33/ST2 axis, hyperplasia, renal injury, unilateral ureteral obstruction (UUO)

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

594
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Stuart Horswell, Tim Chambers

CELL (Cell Press) UK, 19 April 2018

Oncology

Key words: branched evolution, cancer evolution, chromosome instability, deterministic evolution, intratumor heterogeneity, linear evolution, metastasis, punctuated evolution, renal cell cancer, tumor diversity

Organism: Human

Tissue: Kidney

Pathological State: Cancer

595
Tumor-induced generation of splenic erythroblast-like Ter-cells promotes tumor progression

Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, Fan J, Zhou W, Qiu S, Zhang Y, Dong T, Li N, Jiang Z, Zhu H, Zhang Q, Ma Y, Zhang Q, Wang Q, Yu Y, Li N, Cao X

CELL (Cell Press) China, 19 April 2018

Oncology

Key words: Ter-119, Ter-cell, artemin, cancer immunotherapy, erythroblast-like, hepatocellular carcinoma, prognosis biomarker

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

596
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Tim Chambers, Jose I. Lopez, David Nicol

CELL (Cell Press) UK, 19 April 2018

Oncology

Key words: chromosome instability, cytoreductive nephrectomy, evolution of metastasis, loss of 9p, metastasectomy, metastasis, oligometastasis, renal cell cancer, solitary metastasis

Organism: Human

Tissue: Kidney

Pathological State: Cancer

597
Conditional depletion of GSK3b protects oligodendrocytes from apoptosis and lessens demyelination in the acute cuprizone model

Bin Xing Lauren E. Brink Kelly Maers Mara L. Sullivan Richard J. Bodnar Donna B. Stolz Franca Cambi

GLIA (Wiley) USA, 18 April 2018

Neuroscience

Key words: GSK3b, cell death, glia, multiple sclerosis

Organism: Mouse

Tissue: Brain

598
CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer

Teresa P.RaposoabMireia SuecaComescAdeyemiIdowuaBoraAgitaJamesHassallabWakkasFadhilabRobertNicadRupertEckerdTakashiYaoeMohammadIlyas

Experimental and Molecular Pathology (Elsevier) UK, 11 April 2018

Oncology

Key words: CD10, NEP, CALLA, Colorectal cancer, Epithelial-mesenchymal transition, Metastasis

Organism: Human

Tissue: Colon

Pathological State: Cancer

599
Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma

Patrick J. Cimino Youngmi Kim Hua-Jun Wu Jes Alexander, Hans-Georg Wirsching Frank Szulzewsky,1 Ken Pitter,7 Tatsuya Ozawa,1,8 Jiguang Wang,9,10,16 Julio Vazquez,11 Sonali Arora,1 Raul Rabadan Ross Levine Franziska Michor and Eric C. Holland

Genes and Development (Cold Spring Harbor Laboratory Press) USA, 09 April 2018

Oncology

Key words: glioblastoma, HoxA, homeobox RCAS, chromosome 7 gain

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

600
Photodynamic Effect of Methylene Blue and Low Level Laser Radiation in Head and Neck Squamous Cell Carcinoma Cell Lines

Barbara Kofler, Angela Romani, Christian Pritz, Teresa Bernadette Steinbichler, Volker Hans Schartinger, Herbert Riechelmann, Jozsef Dudas

International Journal of Molecular Sciences (MDPI) Austria, 07 April 2018

Oncology

Key words: TissueFaxs, head and neck carcinoma, methylene blue, photodynamic therapy

Organism: Human

Pathological State: Cancer

Cell Line: Detroit 562 cells (pharynx carcinoma)

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