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Customer Publications (A total of 1853 papers published)

401
Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma

K Alikhanyan, Y Chen, S Kraut, R Sotillo

Immunity, Inflammation and Disease (Wiley) Germany, 03 March 2020

Immunology, Oncology

Key words: Alveolar Macrophages, Clodronate Liposomes, EGFR Mutation, Interstitial Macrophages, Lung Cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

402
Artificial intelligence as the next step towards precision pathology

B Acs, M Rantalainen, J Hartman

Journal of Internal Medicine (Wiley) Sweden, 03 March 2020

Medical Imaging

Key words: Artificial Intelligence, Deep Learning, Digital Image Analysis, Digital Pathology, Machine Learning, Pathology

403
Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes

LY Chou, CH Chen, YH Lin, SC Chuang, HC Chou, SY Lin, YC Fu, JK Chang, ML Ho, CZ Wang

The FASEB Journal (FASEB) Taiwan, 03 March 2020

Osteology

Key words: Chondrocytes, DDR1, Discoidin Domain Receptor 1, Endochondral Ossification, Skeletal Development

Organism: Mouse

Tissue: Bone

404
Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Carmen Rapp, Steffen Dettling, Fang Liu, Anna Theresa Ull, Rolf Warta, Christine Jungk, Saskia Roesch, Andreas Mock, Felix Sahm, Melissa Schmidt, Gerhard Jungwirth, Klaus Zweckberger, Katrin Lamszus, Konstaninos Gousias, Almuth F. Kessler, Niels Grabe, Mario Loehr, Ralf Ketter, Steffi Urbschat, Christian Senft, Manfred Westphal, Amir Abdollahi, Juergen Debus, Andreas von Deimling, Andreas Unterberg, Matthias Simon and Christel C. Herold-Mende

Clinical Cancer Research (AACR) Germany, 02 March 2020

Oncology

Key words: Clinically Aggressive Meningioma, T-Cell Infiltration, Primary and Recurrent Tumors TILs, PD-1

Organism: Human

Tissue: Brain

Pathological State: Cancer

405
The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray

ES Gruber, G Oberhuber, D Pils, T Stork, K Sinn, S Gruber, R Nica, D Kolmer, SD Turner, M Schlederer, J Widder, W Doerr, B Teleky, L Kenner

Cancers (MDPI) Austria, 29 February 2020

Oncology

Key words: Irradiated Rectal Cancer, Immunoscore, Virtual Microscopy, Digital Pathology, Tissue Microarray (TMA)

Organism: Human

Tissue: Colon

Pathological State: Cancer

406
Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats

YJ Wu, ME Chien, CH Huang, CC Chiang, CC Lin, CW Huang, DM Durand, KS Hsu

Experimental Neurology (Elsevier) Taiwan, USA, 29 February 2020

Neuroscience

Key words: Status Epilepticus, Seizure, Electroencephalography, Mossy Fiber Sproutin, gBrain -Derived Neurotrophic Factor, Transcranial Direct Current Stimulation

Organism: Rat

Tissue: Brain

Pathological State: Seizures

407
Dermal fillers do not induce upregulation of NLRP3 inflammasomes or expression of inflammatory cytokines in granulomas

Markus Reinholz, Benjamin M. Clanner‐Engelshofen, Markus V. Heppt, Enklajd Marsela, Yoshio Kawakami, Luitgard G. Wiest, Lars E. French, Wilhelm Stolz, Gerd G. Gauglitz

Journal of Cosmetic Dermatology (Wiley) Germany, Japan, 28 February 2020

Dermatology

Key words: Caspase, Fillers, Granulomas, Inflammasome, Interleukins

Organism: Human

Tissue: Skin

408
A transcriptionally distinct CXCL13+ CD103+ CD8+ T-cell population is associated with B-cell recruitment and neoantigen load in human cancer

Hagma H Workel, Joyce M Lubbers, Roland Arnold, Thalina M Prins, Pieter van der Vlies, Kim de Lange, Tjalling Bosse, Inge C Van Gool, Florine A Eggink, Maartje CA Wouters, Fenne L Komdeur, Elisabeth C van der Slikke, Carien L Creutzberg, Arjan Kol, Annechien Plat, Mark Glaire, David N Church, Hans W Nijman and Marco de Bruyn

Cancer immunology Research (AACR) The Netherlands, UK, Canada, 27 February 2020

Oncology

Key words: CXCL13, TGFβ1, Tertiary Lymphoid Structures, CD103+ T Cell, Immune Checkpoint Inhibitors

Organism: Human

Pathological State: Cancer

409
Ultrasound-responsive neurotrophic factor-loaded microbubble-liposome complex: Preclinical investigation for Parkinson's disease treatment

CY Lin, YC Lin, CY Huang, SR Wu, CM Chen, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 27 February 2020

Neuroscience

Key words: Ultrasound (US)-Targeted Microbubble Destruction (UTMD), Gene Therapy, Blood-Brain Barrier Opening, GDNF, BDNF

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's disease

410
cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer

Y He, M Xiao, H Fu, L Chen, L Qi, D Liu, P Guo, L Chen, Y Luo, H Xiao, N Zhang, H Guo

STEM CELLS (Wiley) China, 26 February 2020

Oncology

Key words: Cancer Stem Cells, CD133, CD24, CD44, cPLA2α, Epithelial‐Mesenchymal Transition

Organism: Human

Tissue: Uterus

Pathological State: Cancer

411
Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway

H Kim, SC Cho, HJ Jeong, HY Lee, MH Jeong, JH Pyun, D Ryu, MS Kim, YS Lee, MS Kim, SC Park, YI Lee, JS Kang

Journal of Cachexia , Sarcopenia and Muscle (Wiley) South Korea, 25 February 2020

Neuroscience

Key words: Exercise Mimetic, Hypertrophic Response, Indoprofen, Muscle Wasting, Muscle Weakness, PDK1

Organism: Mouse

Tissue: Muscle

412
Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations

P Chen, S Lou, ZH Huang, Z Wang, QH Shan, Y Wang, Y Yang, X Li, H Gong, Y Jin, Z Zhang, JN Zhou

Neuron (Cell Press) China, 25 February 2020

Neuroscience

Key words: Corticotropin-Releasing Factor Neurons, Prefrontal Cortex, Behavioral Style Selection, Social Defeat Stress

Organism: Mouse

Tissue: Brain

413
Sox2 induces tumorigenesis and angiogenesis of early-stage esophageal squamous cell carcinoma through secretion of Suprabasin

Kiichi Takahashi, Naoki Asano, Akira Imatani, Yutaka Kondo, Masashi Saito, Akio Takeuchi, Xiaoyi Jin, Masahiro Saito, Waku Hatta, Kiyotaka Asanuma, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

Carcinogenesis (Oxford University Press) Japan, 14 February 2020

Oncology

Key words: Sox2, Esophageal Cancer, Suprabasin, Carcinogenesis, Angiogenesis

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

414
The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental Study on Porcine Models

Tomáš Andrašina, Josef Jaroš, Tomáš Jůza, Tomáš Rohan, Dalibor Červinka, Michal Crha, Vlastimil Válek & Nahum S. Goldberg

Cardiovascular and Interventional Radiology (Springer) Czech Republic, Israel, 13 February 2020

Cardiology

Key words: Liposomal Doxorubicin, Radiofrequency Ablation, Irreversible Electroporation

Organism: Pig

Tissue: Liver

415
The Impact of Cand1 in Prostate Cancer

Andrea Eigentler, Piotr Tymoszuk, Johanna Zwick, Arndt A. Schmitz, Andreas Pircher, Florian Kocher, Andreas Schlicker, Ralf Lesche, Georg Schäfer, Igor Theurl, Helmut Klocker, Isabel Heidegger

Cancers (MDPI) Austria, Germany, 12 February 2020

Oncology

Key words: Prostate Cancer, Cand1, Cancer Aggressiveness, Survival, Tumor Recurrence, Mutation, Enzalutamide Resistance

Organism: Human

Tissue: Prostate

Pathological State: Cancer

416
Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance

J Dudas, A Ladanyi, J Ingruber, TB Steinbichler, H Riechelmann

Cells (MDPI) Austria, Hungary, 12 February 2020

Oncology

Key words: Silibinin, MRX34, PD-L1, NRF2, Krüppel-Like Factors (KLFs), Neurotrophin

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

417
MRI radiomics for early prediction of response to vaccine therapy in a transgenic mouse model of pancreatic ductal adenocarcinoma

A Eresen, J Yang, J Shangguan, Y Li, S Hu, C Sun, Y Velichko, V Yaghmai, AB Benson, Z Zhang

Journal of Translational Medicine (BMC) USA, China, 10 February 2020

Gastroenterology

Key words: Dendritic Cell Vaccine, Machine Learning, Magnetic Resonance Imaging, Pancreatic Ductal Adenocarcinoma, Radiomics

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

418
Single cell approaches to address adipose tissue stromal cell heterogeneity

EA Rondini, JG Granneman

Biochemical Journal (Portland Press) USA, 06 February 2020

Endocrinology

Key words: Plasticity, Single Cell RNA-Seq, Stromal Cells, White Adipose Tissue

419
Acquisition of chromosome instability is a mechanism to evade oncogene addiction

L Salgueiro, C Buccitelli, K Rowald, K Somogyi, S Kandala, JO Korbel, R Sotillo

EMBO Molecular Medicine (EMBO press) Germany, 06 February 2020

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

420
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability

WC Liao, CK Liao, TJ Tseng, YJ Ho, YR Chen, KH Lin, TJ Lai, CT Lan, KC Wie, CH Liu

Oncogenesis (Nature) Taiwan, 04 February 2020

Oncology

Key words: CNS Cancer, Growth Factor Signalling

Organism: Human

Tissue: Brain

Pathological State: Cancer

421
Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy

Y Luo, S Lu, Y Gao, K Yang, D Wu, X Xu, G Sun, X Sun

Aging (Impact Journals) China, 31 January 2020

Cardiology

Key words: Atherosclerosis, Macrophage Polarization, Autophagy, Sirt1, Araloside C

Organism: Mouse

Tissue: Heart

Pathological State: Atherosclerosis

422
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I

F Bufalieri, M Caimano, L Lospinoso Severini, I Basili, F Paglia, L Sampirisi, E loricchio, M Petroni, G Canettieri, A Santoro, L D'Angelo, P Infante, L Di Marcotullio

Cancers (MDPI) Italy, 30 January 2020

Oncology

Key words: Glioblastoma Multiforme (GB), Ubiquitylation, E3-Ligase, MEX3A, RIG-I

Organism: Human

Pathological State: Cancer

Cell Line: glioblastoma A-172 cells

423
Unidirectional rotating molecular motors dynamically interact with adsorbed proteins to direct the fate of mesenchymal stem cells

Q Zhou, J Chen, Y Luan, PA Vainikka, S Thallmair, SJ Marrink, BL Fering, P van Rijn

Science Advances (AAAS) China, The Netherlands, 29 January 2020

Biological Materials

Organism: Human

Cell Line: hBM-MSCs Cells

424
Cytotoxic CD4+ T lymphocytes may induce epithelial cell apoptosis in systemic sclerosis

Takashi Maehara, Naoki Kaneko, Cory Adam Perugino, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S. Mahajan, Hang Liu, Samuel J.H. Murphy, Musie Ghebremichael, David A. Fox, Aimee S. Payne, Robert Lafyatis, John H. Stone, Dinesh Khanna, and Shiv Pillai

Journal of Clinical Investigation (American Society of Clinical Investigation) USA, Japan, The Netherlands, Canada, China, 28 January 2020

Immunology

Organism: Human

Tissue: Skin

425
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas

J He, Z Huang, M He, J Liao, Q Zhang, S Wang, L Xie, L Ouyang, HP Koeffler, D Yin, A Liu

Molecular Cancer (BMC) China, USA, 28 January 2020

Oncology

Key words: Circ-MAPK4, P38/MAPK Signaling Pathway, MiR-125a-3p, Gliomas, Apoptosis

Organism: Mouse

Tissue: Xenograft Tumor, Brain

Pathological State: Cancer

426
Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice

N Ran, X Gao, X Dong, J Li, C Lin, M Geng, HF Yin

Biomaterials (Elsevier) China, 25 January 2020

Biological Materials

Key words: Exosome, Duchenne Muscular Dystrophy, Myostatin, Propeptide

Organism: Rat

Tissue: Muscle, Liver, Kidney

427
The Establishment of Esophageal Precancerous Lesion Model by Using p53 Conditional Knockout Mouse in Esophageal Epithelium

L Zhu, Y Xu, X Chen, J Qin, T Niu, Y Zhu, Y Jiang, S Zhao, K Liu, J Lu, G Jin, J Ma

BioMed Research International (Hindawi Publishing Corporation) China, 25 January 2020

Oncology

Organism: Mouse

Tissue: Esophagus

428
Surfactant expression defines an inflamed subtype of lung adenocarcinoma brain metastases that correlates with prolonged survival

Kolja Pocha, Andreas Mock, Carmen Rapp, Steffen Dettling, Rolf Warta, Christoph Geisenberger, Christine Jungk, Leila R Martins, Niels Grabe, David Reuss, Jürgen Debus, Andreas von Deimling, Amir Abdollahi, Andreas Unterberg and Christel C Herold-Mende

Clinical Cancer Research (AACR) Germany, 17 January 2020

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

429
Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation

E Jo, HJ Jang, KE Yang MS Jang, YH Huh, HS Yoo, JS Park, IK Jang, SJ Park

BMC Complementary Medicine and Therapies (BMC) South Korea, 13 January 2020

Oncology

Key words: Apoptosis, TNF-α, TNFR1, NF-κB, C. Militaris

Organism: Human

Cell Line: SKOV-3 Cells

430
High Extra-tumoral Mast Cell Counts are Associated with a Higher Risk of Adverse Prostate Cancer Outcomes

HH Sullivan, CM Heaphy, I Kulac, N Cuka, J Lu, JR Barber, AM De Marzo, TL Lotan, CE Joshu, KS Sfanos

Cancer Epidemiology, Biomarkers & Prevention (AACR) USA, 13 January 2020

Oncology

431
Novel titanium-apatite hybrid scaffolds with spongy bone-like micro architecture intended for spinal application: In vitro and in vivo study

MD Vlad, EF Aguado, SG González, IC Ivanov, EV Sindilar, I Poeata, AS Iencean, M Butnaru, ER Avadanei, J Lopez Lopez

Materials Science and Engineering: C (Elsevier) Romania, Spain, 11 January 2020

Biological Materials

Key words: Titanium-Apatite Hybrid Scaffolds, Osteogenic Biomimetic Porous Scaffolds, Hydroxyapatite Bioactive Matrix, Bone Restoration, Spinal Fusion, Additive Manufacturing

Organism: Human

Cell Line: Osteoblasts

432
Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model

D Muschter, L Fleischhauer, S Taheri, AF Schilling, H Clausen-Schaumann, S Grässel

Bone (Elsevier) Germany, 08 January 2020

Osteology

Key words: Osteoarthritis, Destabilization of The Medial Meniscus, Substance P, Alpha- Calcitonin Gene-Related Peptide, Bone, Cartilage

Organism: Mouse

Tissue: Bone

433
Racial difference in prostate cancer cell telomere lengths in men with higher-grade prostate cancer: a clue to the racial disparity in prostate cancer outcomes

CM Heaphy, CE Joshu, JR Barber, C Davis, R Zarinshenas, AM De Marzo, TL Lotan, KS Sfanos, AK Meeker, EA Platz

Cancer Epidemiology, Biomarkers & Prevention (AACR) USA, 08 January 2020

Oncology

434
Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer

CW Chang, HC Lee, LH Li, JS Chiang Chiau, TE Wang, WH Chuang, MJ Chen, HY Wang, SC Shih, CY Liu, TH Tsai, YJ Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 08 January 2020

Oncology, Microbiology

Key words: FOLFOX, Fecal Microbiota Transplant, Intestinal Mucositis, Apoptosis, Gut Microbiota

Organism: Mouse

Tissue: Small Intestine

Pathological State: Cancer

435
Impact of the Sensory and Sympathetic Nervous System on Fracture Healing in Ovariectomized Mice

T Niedermair, RH Straub, C Brochhausen, S Grässel

International Journal of Molecular Sciences (MDPI) Germany, 08 January 2020

Neuroscience

Key words: Fracture, Substance P, Alpha-CGRP, Sympathectomy, Sympathetic Nerve Fibers, Ovariectomy, Sensory Nervous System, Bone Repair, Bone Remodeling

Organism: Mouse

Tissue: Bone

436
Efficient Labeling Of Mesenchymal Stem Cells For High Sensitivity Long-Term MRI Monitoring In Live Mice Brains

AAA Ali, RA Shahror, KY Chen

International Journal of Nanomedicine (Dove Press) Taiwan, 08 January 2020

Nanomedicine

Key words: Iron Oxide Nanoparticles, FGF21, Regenerative Medicine, Tracking of Cells, Non-Invasive Imaging Modality

Organism: Human

Cell Line: Mesenchymal Stem Cells

437
Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway

D Liu, H Wang, Y Zhang, Z Zhang

Drug Design, Development and Therapy (Dove Press) China, 07 January 2020

Neuroscience

Key words: Cerebral Ischemia/Reperfusion Injury, Chlorogenic Acid, Oxidative Stress, Neuroprotection, NF-E2-Related Factor 2 Pathway

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

438
The MyoD family inhibitor domain-containing protein enhances the chemoresistance of cancer stem cells in the epithelial state by increasing β-catenin activity

CJ Chen, CJ Yang, SF Yang, MS Huang, YP Liu

Oncogene (Nature) Taiwan, 07 January 2020

Oncology

Key words: Non-Small Lung Cancer, Prognostic

Organism: Human

Tissue: Lung

Pathological State: Cancer

439
TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior

CH Chu, JS Chen, PC Chuang, CH Su, ZL Chan, ZJ Zang, ZT Chiang, PW Gean, HS Sun

The FASEB Journal (Wiley) Taiwan, 07 January 2020

Neuroscience

Key words: Guanine Nucleotide Exchange Factor (GEF), Hyperlocomotion, Neuroplasticity, Serotonergic Fiber, Serotonin (5‐HT), TIAM2

Organism: Mouse

Tissue: Brain

440
Microvascular Disease in Chronic Thromboembolic Pulmonary Hypertension: Hemodynamic Phenotyping and Histomorphometric Assessment

Christian Gerges, Mario Gerges, Richard Friewald, Pierre Fesler, Peter Dorfmüller, Smriti Sharma, Kristof Karlocai, Nika Skoro-Sajer, Johannes Jakowitsch, Bernhard Moser, Shahrokh Taghavi, Walter Klepetko, Irene M. Lang

Circulation (American Heart Association) Austria, Germany, France, Hungary, 03 January 2020

Cardiology

Key words: Chronic Thromboembolic Pulmonary Hypertension, Upstream Resistance, Pulmonary Vascular Resistance, Pulmonary Arterial Compliance, Microvascular Disease

Organism: Human

Tissue: Lung

441
Anti-BAFF treatment interferes with humoral responses in a model of renal transplantation in rats

L Steines, H Poth, A Schuster, EK Geissler, K Amann, B Banas, T Bergler

Transplantation (Wolters Kluwer) Germany, 01 January 2020

Transplantation Medicine

Organism: Rat

Tissue: Kidney

442
Effects of neoadjuvant FOLFIRONOX and gemcitabine-based chemotherapy on cancer cell survival and death in patients with pancreatic ductal adenocarcinoma

L Xie, L Xia, U Klaiber, M Sachsenmaier, U Hinz, F Bergmann, O Strobel, MW Büchler, JP Neoptolemos, F Fortunato, T Hackert

Oncotarget (Impact Journals) Germany, 31 December 2019

Oncology

Key words: autophagy, cell death, stroma, neoadjuvant therapy, prognosis

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

443
Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo

JH Chen, I Chiang, FT Hsu

Cancers (MDPI) Taiwan, 30 December 2019

Oncology

Key words: Magnolol, Sorafenib, AKT, Hepatocellular carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

444
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra

YC Kao, WY Wei, KJ Tsai, LC Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 27 December 2019

Neuroscience

Key words: high-fat diet (HFD), dopamine (DA), Parkinson disease (PD), peroxisome proliferator-activated receptor (PPAR)

Organism: Mouse

Tissue: Brain

445
Nanoplatforms with Remarkably Enhanced Absorption in the Second Biological Window for Effective Tumor Thermo-Radiotherapy

C Zhang, D Men, T Zhang, Y Yu, J Xiang, G Jiang, and L Han

ACS Applied Materials & Interfaces (ACS Publications) China, 25 December 2019

Nanomedicine

Key words: Copper sulfide, Gold, Second near-infrared window, Thermo-radiotherapy, Synergistic effect

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

446
Heat-killed Mycobacterium paragordonae therapy exerts an anti-cancer immune response via enhanced immune cell mediated oncolytic activity in xenograft mice model

SY Lee, SB Yang, YM Choi, SJ Oh, BJ Kim, YH Kook, BJ Kim

Cancer Letters (Elsevier) South Korea, 23 December 2019

Oncology

Key words: Cancer immnotherapy, Natural killer cells, Dendritic cells, Interleukin-12

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

447
Dendritic cells treated with a prostaglandin I2 analog, iloprost, promote antigen-specific regulatory T cell differentiation in mice

TH Wong, RJ Gau, YF Chen, HH Shen, CTY Lin, SL Chen, JL Suen

International Immunopharmacology (Elsevier) Taiwan, 23 December 2019

Immunology

Key words: Allergic inflammation, Prostaglandin I2, mPEG-PLGA hydrogel, Regulatory T-cell, Tolerogenic dendritic cell, PD-L1

Organism: Mouse

Tissue: Lung

448
Switching to a Healthy Diet Prevents the Detrimental Effects of Western Diet in a Colitis-Associated Colorectal Cancer Model

C Gröschel, M Prinz-Wohlgenannt, I Mesteri, S Karuthedom George, L Trawnicek, D Heiden, A Aggarwal, S Tennakoon, M Baumgartner, C Gasche, M Lang, R Marculescu, T Manhardt, M Schepelmann, E Kallay

Nutrients (MDPI) Austria, Germany, 23 December 2019

Oncology, Gastroenterology

Key words: inflammatory bowel disease, colitis-associated cancer, microbiome, western diet, vitamin D, non-alcoholic fatty liver disease, CYP24A1, Wnt pathway, aberrant crypt foci, mucosal regeneration

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

449
Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer

JY Huang, YY Wang, S Lo, LM Tseng, DR Chen, YC Wu, MF Hou, SSF Yuan

Cancers (MDPI) Taiwan, 20 December 2019

Oncology

Key words: Breast cancer, Visfatin, Adipose-derived stem cells (ADSCs), GDF15

Organism: Human

Tissue: Breast

Pathological State: Cancer

450
Modulating Macrophage Phenotype by Sustained MicroRNA Delivery Improves Host‐Implant Integration

J Lin, I Mohamed, PH Lin, H Shirahama, U Milbreta, JL Sieow, Y Peng, M Bugiani, SC Wong, H Levinson, SY Chew

Advanced Healthcare Materials (Wiley) Singapore, USA, The Netherlands, 18 December 2019

Tissue Engineering

Key words: Electrospinning, Fibrous capsule formation, Gene silencing, RNA interference, Tissue engineering

Organism: Mouse

451
Rhubarb-evoke Mucus Secretion through Aggregation and Degranulation of Mast cell in the colon of Rat: in vivo and ex vivo studies

D Wu, X Xue, C Gao, Y Liu, T Wang, L Li, X Tong, F Li, J Xu

Scientific Reports (Nature) China, 18 December 2019

Gastroenterology

Key words: Gastroenterology, Physiology

452
Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence

M Jäger, C De la Torre, C Arnold, J Kohlhaas, L Kappert, M Hecker, A Feldner, T Korff

Experimental Cell Research (Elsevier) Germany, 16 December 2019

Tissue Engineering

Key words: TGF, Vascular smooth muscle cells, Differentiation, 3D culture

Organism: Human

Cell Line: HUASMCs

453
Effects of Circadian Rhythm Disorder on the Hippocampus of SHR and WKY Rats

YL Wang, YG Zhang, WZ Wang, X Liu, YF Chi, JF Lei, BG Zhang, T Zhang

Neurobiology of Learning and Memory (Elsevier) China, 16 December 2019

Neuroscience

Key words: Circadian rhythm disorder, Hypertension, Cognition, Hippocampus

Organism: Rat

Tissue: Brain

Pathological State: Circadian Rhythm Disorder

454
Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice

T Elajnaf, L Iamartino, I Mesteri, C Müller, M Bassetto, T Manhardt, S Baumgartner-Parzer, E Kallay, M Schepelmann

Nutrients (MDPI) Austria, Germany, UK, 16 December 2019

Gastroenterology

Key words: IBD, Colitis, Inflammation, Calcium, Mucin

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

455
Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations

Daniel Y. Zhang, Crismita Dmello, Li Chen, Victor A. Arrieta, Edgar Gonzalez-Buendia, J. Robert Kane, Lisa P. Magnusson, Aneta Baran, C. David James, Craig Horbinski, Alexandre Carpentier, Carole Desseaux, Michael Canney, Miguel Muzzio, Roger Stupp and Adam M. Sonabend

Clinical Cancer Research (AACR) USA, Mexico, France, 12 December 2019

Oncology

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

456
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice

Katherine C. Wood , Brittany G. Durgin , Heidi M. Schmidt , Scott A. Hahn , Jeffrey J. Baust , Tim Bachman , Dario A. Vitturi , Samit Ghosh , Solomon F. Ofori-Acquah , Ana L. Mora , Mark T. Gladwin , Adam C. Straub

Blood Advances (ASH Publications) USA, 10 December 2019

Cardiology

Organism: Mouse

Tissue: Heart

457
Targeting FOXA1-mediated repression of TGF-b signaling suppresses castration-resistant prostate cancer progression

Song B, Park SH, Zhao JC, Fong KW, Li S, Lee Y, Yang YA, Sridhar S, Lu X, Abdulkadir SA, Vessella RL, Morrissey C, Kuzel TM, Catalona W, Yang X, Yu J

JCI insight (American Society of Clinical Investigation) USA, 04 December 2019

Oncology

Key words: Genetics, Oncology, Prostate Cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

458
Molecular Pattern and Density of Axons in the Long Head of the Biceps Tendon and the Superior Labrum

S Boesmueller, R Blumer, B Gesslbauer, L Hirtler, C Fialka, R Mittermayr

Journal of Clinical Medicine (MDPI) Austria, 03 December 2019

Physiology

Key words: axons, pain, long head of the biceps tendon, superior labrum, SLAP

Organism: Human

Tissue: Connective Tissue

459
Early appearance of key transcription factors influence the spatiotemporal development of the human inner ear

LJ Chacko, C Sergi, T Eberharter, J Dudas, H Rask-Anderson, R Hoermann, H Fritsch, N Fischer, R Glueckert, A Schrott-Fischer

Cell and Tissue Research (Springer) Austria, Canada, Sweden, 02 December 2019

Developmental Biology

Key words: Inner ear, Human, Transcription factors, Immunohistochemistry, SOX2, TAK1, GATA3, Electron microscopy

Organism: Human

Tissue: Bone

460
PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes

MH Jeong, HJ Jeong, BY Ahn, JH Pyun, I Kwon, H Cho, JS Kang

Cell Death & Disease (Nature) South Korea, 02 December 2019

Cardiology

Key words: Cell death, Heart failure

Organism: Mouse

Tissue: Heart

461
Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease: A case report

T Maehara, R Munemura, M Shimizu, N Kakizoe, N Kaneko, Y Murakami, M Masafumi, T Kiyoshima, S Kawano, S Nakamura

Medicine (Wolters Kluwer) Japan, USA, 01 December 2019

Immunology

Key words: CD4+ T cell, CD4+ GATA3+ T cell, IgE, Kimura disease, mast cell

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Kimura Disease

462
Histologic Analysis of Sensory and Motor Axons in Branches of the Human Brachial Plexus

LM Mioton, GA Dumanian, A Gregory, M de la Garza, JH Ko

Plastic and Reconstructive Surgery (American Society of Plastic Surgeons) USA, 01 December 2019

Regenerative Medicine

Organism: Human

Tissue: Nerves

463
Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI

T Chiba, KD Peasley, KR Cargill, KV Maringer, SS Bharathi, E Mukherjee, Y Zhang, A Holtz, N Basisty, SD Yagobian, B Schilling, ES Goetzman, S Sims-Lucas

Journal of The American Society of Nephrology (American Society of Nephrology) USA, 29 November 2019

Nephrology

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

464
Development of Kaempferol-Loaded Gelatin Nanoparticles for the Treatment of Corneal Neovascularization in Mice

YL Chuang, HW Fang, A Ajitsaria, KH Chen, CY Su, GS Liu, CL Tseng

Pharmaceutics (MDPI) Taiwan, Australia, 28 November 2019

Nanomedicine

Key words: gelatin nanoparticles, kaempferol, corneal neovascularization, anti-angiogenesis, human umbilical vascular endothelial cells (HUVECs)

Organism: Mouse

Tissue: Eye

465
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

Lercher A, Bhattacharya A, Popa AM, Caldera M, Schlapansky MF, Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner JS, Vitko D, Pinter T, Genger JW, Orlova A, Pikor N, Reil D, Ozsvár-Kozma M, Kalinke U, Ludewig B, Moriggl R, Bennett KL, Menche J, Cheng PN, Schabbauer G, Trauner M, Klavins K, Bergthaler A

Immunity (Elsevier) Austria, USA, Switzerland, Germany, China, 26 November 2019

Immunology

Key words: CD8 T cells, hepatitis, hepatocyte, immunometabolism, infection, inflammation, interferons, liver, urea cycle, virus

Organism: Mouse

Tissue: Liver

466
DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

SC Lai, YT Su, CC Chi, YC Kuo, KF Lee, YC Wu, PC Lan, MH Yang, TS Chang, YH Huang

Jornal of Experimental & Clinical Cancer Research (BMC) Taiwan, 26 November 2019

Oncology

Key words: , Interleukin-6, Phospho-STAT3, OCT4, DNMT3b, Drug resistance, Hepatocellular carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

467
Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice

CM Smith, MK Proulx, R Lai, MC Kiritsy, TA Bell, P hock, FP de Villena, MT Ferris, RE Baker, SM Behar, CM Sassetti

mBio (American Society for Microbiology) USA, 26 November 2019

Microbiology

Key words: Mycobacterium tuberculosis, adaptive immunity, Collaborative Cross mice, host genetics, host response, host-pathogen interactions

Organism: Mouse

Tissue: Lung

Pathological State: M. Tuberculosis Infection

468
Promising Therapeutic Efficacy of GC1118, an Anti-EGFR Antibody, against KRAS Mutation-Driven Colorectal Cancer Patient-Derived Xenografts

HW Lee, E Son, K Lee, Y Lee, Y Kim, JC Lee, Y Lim, M Hur, D Kim, DH Nam

International Journal of Molecular Sciences (MDPI) South Korea, 24 November 2019

Oncology

Key words: colorectal cancer, patient-derived xenograft, EGFR-targeting therapeutic antibody, KRAS mutation, PI3K/mTOR/AKT inhibitor

Organism: Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

469
Translational interest of immune profiling

PN Pushparaj

Precision Medicine for Investigators, Practitioners and Providers (Elsevier) Saudi Arabia, 22 November 2019

Immunology

Key words: Biomarkers, Immunoprofiling, Multiplex Immunohistochemistry, Novel Therapies, Next Generation Sequencing, Protein Arrays, Translational Research, xMAP Assays

470
Cordycepin inhibits human ovarian cancer by inducing autophagy and apoptosis through Dickkopf-related protein 1/β-catenin signaling

HJ Jang, KE Yang, IH Hwang, YH Huh, DJ Kim, KS Yoo, SJ Park, IS Jang

American Journal of Translational Regulation (NCBI) South Korea, 15 November 2019

Oncology

Key words: Apoptosis, Dickkopf-related protein 1, β-catenin, autophagy, cordycepin

Organism: Human

Pathological State: Cancer

Cell Line: SKOV-3, OVCAR-3

471
Influence of Platelet Lysate on 2D and 3D Amniotic Mesenchymal Stem Cell Cultures

M Pasztorek, E Rossmanith, C Mayr, F Hauser, J Jacak, A Ebner, V Weber, MB Fischer

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) Austria, 15 November 2019

Regenerative Medicine

Key words: mesenchymal stem cells, stress fibers, mitochondrial dynamics, platelet lysate, membrane elasticity

Organism: Human

Cell Line: hMSCs

472
Endoplasmic reticulum stress-mediated basolateral amygdala GABAergic neuron injury is associated with stress-induced mental disorders in rats

S Wang, W Shi, G Zhang, X Zhang, C Ma, K Zhao, B Cong, Y Li

Frontiers in cellular Neuroscience (NCBI) China, Usa, Mexico, 14 November 2019

Neuroscience

Key words: stress, amygdala, GABAergic neurons, mental disorder, endoplasmic reticulum stress

Organism: Rat

Tissue: Brain

473
Large‐scale Production of LGR5‐positive Bipotential Human Liver Stem Cells

Kerstin Schneeberger, Natalia Sánchez‐Romero, Shicheng Ye, Frank G. van Steenbeek, Loes A. Oosterhoff, Iris Pla Palacin,Chen Chen, Monique E. van Wolferen, Gilles van Tienderen, Ruby Lieshout, Haaike Colemonts‐Vroninks, Imre Schene, Ruurdtje Hoekstra, Monique M.A. Verstegen, Luc J.W. van der Laan, Louis C. Penning, Sabine A. Fuchs, Hans Clevers, Joery De Kock, Pedro M. Baptista, Bart Spee

Hepatology (AASLD) The Netherlands, Spain, Belgium, 12 November 2019

Hepathology

Key words: Liver organoids, suspension culture, spinner flask, hepatocyte differentation, tissue engineering

Organism: Human

Tissue: Liver

474
Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection

PL Brazee, L Morales-Nebreda, ND Magani, JGN Garcia, AV Misharin, KM Ridge, GRS Budinger, K Iwai, LA Dada, JI Sznajder

Journal of Clinical Investigation (American Society of Clinical Investigation) USA, Japan, 12 November 2019

Immunology

Organism: Mouse

Tissue: Lung

Pathological State: Infulenza Infection

475
P2Y6 and P2X7 receptor antagonism exerts neuroprotective/neuroregenerative effects in an animal model of Parkinson's disease

Á Oliveira-Giacomelli, CM Albino, HD Nobrega de Souza, J Correa-Velloso, AP de Jesus Santos, J Baranova, H Ulrich

Frontiers in cellular Neuroscience (Frontiers Media S.A.) Brazil, 08 November 2019

Neuroscience

Key words: purinergic receptors, Brilliant Blue G, P2X7 receptor, MRS2578, P2Y6 receptor, Parkinson’s disease, microglia

Organism: Rat

Tissue: Brain

Pathological State: Prakinson's Disease

476
A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer

L Ding, J Li, C Wu, F Yan, X Li, S Zhang

Journal of Materials Chemistry B (Royal Society of Chemistry) China, 08 November 2019

Nanomedicine, Oncology

Organism: Human

Pathological State: Cancer

Cell Line: MDA-MB-231 cells, MCF-7 cells and HeLa cells

477
Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival

S Lu, D Wu, G Sun, F Geng, Y Shen, J Tan, X Sun, Y Luo

Pharmaceutical Biology (Taylor & Francis) China, 07 November 2019

Gastroenterology

Key words: Periplaneta americana L., gastric diseases, IGF-1/PTEN/Akt signalling, KFX

Organism: Rat

Tissue: Stomach

Pathological State: Gastric Ulcer

478
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis

CM Mazur, JJ Woo, CS Yee, AJ Fields, C Acevedo, KN Bailey, S Kaya, TW Fowler, JC Lotz, A Dang, AC Kuo, TP Vail, T Alliston

Bone research (Nature) USA, 05 November 2019

Osteology

Key words: Bone, Bone quality and biomechanics, Pathogenesis

Organism: Human

Tissue: Bone

479
Well Plate Integrated Topography Gradient Screening Technology for Studying Cell‐Surface Topography Interactions

TAB van der Boon, L Yang, L Li, DE Cordova, Galvan, Q Zhou, J e Boer, P van Rijn

Advanced Biosystems (Wiley) The Netherlands, China, 04 November 2019

Biological Materials

Key words: Biointerfaces, gradients, high-throughput screening, stem cells surface topography

Organism: Human

Cell Line: hBM-MSCs

480
Mapping of c-Fos expression in male tree shrew forebrain

RJ Ni, J Wang, YM Shu, L Xu, JN Zhou

Neuroscience letters (Elsevier) China, 03 November 2019

Neuroscience

Key words: Aversive stimulus, Prefrontal cortex, Lateral septal nucleus, Bed nucleus of the stria terminalis, Hypothalamus, Amygdala

Organism: Tree Shrew

Tissue: Brain

481
Dendritic cell immunotherapy induces anti-tumor effect in a transgenic mouse model of pancreatic ductal adenocarcinoma

J Yang, S Hu, J Shangguan, A Eresen, Y Li, L Pan, Q Ma, Y Velichko, J Wang, C Hu, V Yagmai, Z Zhang

American Journal of Cancer Research (NCBI) USA, China, 01 November 2019

Oncology

Key words: Pancreatic ductal adenocarcinoma, DC-based immunotherapy, magnetic resonance imaging

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

482
Phospholipase D2 in prostate cancer: protein expression changes with Gleason score

AR Noble, K Hogg, R Suman, DM Berney, S Bourgoin, NJ Maitland, MG Rumsby

British journal of Cancer (Nature) UK, Canada, 01 November 2019

Oncology

Key words: Cell growth, Prostate cancer, Time-lapse imaging

Organism: Human

Tissue: Prostate

Pathological State: Cancer

483
A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer

HW Chiu, YL Yeh, SY Ho, YH Wu, B Wang Jr, WJ Huang, YS Ho, YJ Wang, LC Chen, SH Tu

Cancers (MDPI) Taiwan, 01 November 2019

Oncology

Key words: histone deacetylase inhibitor, aggresome, radiation, autophagy, triple-negative breast cancer

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

484
Directional topography gradients drive optimum alignment and differentiation of human myoblasts

AMA Suarez, Q Zhou, P van Rijn, MC Harmsen

Journal of Tissue Engineering and Regenerative Medicine (Wiley) The Netherlands, 01 November 2019

Regenerative Medicine

Key words: Myoblasts, Myotubes, Polydimethylsiloxane (PDMS), Tissue Engineering, Topography Gradient

Organism: Human

Cell Line: Myoblasts

485
Responsive exosome nano‐bioconjugates for synergistic cancer therapy

W Nie, G Wu, J Zhang, LL Huang, J Ding, A Jiang, Y Zhang, Y Liu, J Li, K Pu, HY Xie

Angewandte Chemie (Wiley) China, Singapore, 31 October 2019

Nanomedicine

Key words: Exosome, immunotherapy, antibodies, cancer, nanoconjugate

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

486
Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

KQ Fan, YY Li, HL Wang, XT Mao, JX Guo, F Wang, LJ Huang, YN Li, XY Ma, ZJ Gao, W Chen, DD Qian, WJ Xue, Q Cao, L Zhang, L Shen, L Zhang, C Tong, JY Zhong, W Lu, L Lu, KM Ren, G Zhong, Y Wang, M Tang, XH Feng, RJ Chai, J Jin

CELL (Cell Press) China, 31 October 2019

Neuroscience

Key words: T cell, stress, leukotriene B4, anxiety, purine metabolism, amygdala, AdorA1, IRF-1, xanthine

Organism: Mouse

Cell Line: CD4 T Cells

487
Distribution of Tyrosine‐Hydroxylase‐Immunoreactive Neurons in the Hypothalamus of Tree Shrews

ZH Huang, RJ Ni, PH Luo, JN Zhou

Journal of Comparative Neurology (Wily) China, 31 October 2019

Neuroscience

Key words: Tyrosine hydroxylase, Hypothalamus, Immunohistochemistry, RRID: AB_2201526, Vasopressin, Aromatic L-amino acid decarboxylase

Organism: Tree Shrew

Tissue: Brain

488
Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model

S Sudirman, CS Lai, YL Yan, HI Yeh, ZL Kong

Scientific Reports (Nature) Taiwan, 23 October 2019

Endocrinology

Key words: Experimental models of disease, Immunology

Organism: Mouse

Tissue: Heart, Kidney

Pathological State: Diabetes Type 2

489
Nasal Pneumococcal Density is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens

Elena Mitsi , Beatriz Carniel , Jesús Reiné , Jamie Rylance , Seher Zaidi , Alessandra Soares-Schanoski , Victoria Connor , Andrea M Collins , Andreas Schlitzer , Elissavet Nikolaou , Carla Solórzano , Sherin Pojar , Helen Hill , Angela D Hyder-Wright , Kondwani C Jambo , Marco R Oggioni , Megan De Ste Croix , Stephen B Gordon , Simon P Jochems , and Daniela M Ferreira

American Journal of Respiratory and Critical Care Medicine (ATS Journals) UK, Brazil, Germany, Malawi, The Netherlands, 18 October 2019

Immunology

Key words: Nasopharygeal colonization, Microaspiration, Alveolar macrophages, Controlled Human Infection model, CD4+ T cells

Organism: Human

Cell Line: BAL Cells

490
Human Mesenchymal Stem Cell Response to Lactoferrin-based Composite Coatings

M Icriverzi, A Bonciu, L Rusen, LE Sima, S Brajnicov, A Cimpean, RW Evans, V Dinca, A Roseanu

Materials (MDPI) Romania, UK, 18 October 2019

Biological Materials

Key words: mesenchymal stem cells, osteogenic differentiation, lactoferrin, polymer composite

Organism: Human

Cell Line: hMSCs

491
Facile and efficient encapsulation of antimicrobial peptides via crosslinked DNA nanostructures and their application in wound therapy

S Obuobi, HKL Tay, NDT Tram, V Selvarajan, J Singh Khara, Y Wang, PLR Ee

Journal of Controlled Release (Elsevier) Singapore, 16 October 2019

Nanomedicine

Key words: DNA hydrogel, S. aureus infection, Wound healing, Antimicrobial peptides, Controlled release, Electrostatic interactions

Organism: Mouse

Tissue: Skin

Pathological State: Wound

492
Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

MK Graham, J Kim, J Da, JA Brosnan-Cashman, A Rizzo, JA Baena Del Valle, L Chia, M Rubenstein, C Davis, Q Zheng, L Cope, M Considine, MC Haffner, AM De Marzo, AK Meeker, CM Heaphy

Molecular Cancer  Research (AACR) USA, 14 October 2019

Oncology

Key words: ATRX, TERC, Telomeres, Alternative lengthening of telomeres, Cancer, Prostate cancer, telomerase, gene knockout, CRISPR/Cas

Organism: Human

Pathological State: Cancer

Cell Line: LAPC-4 Cells

493
Comparing the Osteogenic Potentials and Bone Regeneration Capacities of Bone Marrow and Dental Pulp Mesenchymal Stem Cells in a Rabbit Calvarial Bone Defect Model

YC Lee, YH Chan, SC Hsieh, WZ Lew, SW Feng

International Journal of Molecular Sciences (MDPI) Taiwan, 10 October 2019

Regenerative Medicine

Key words: mesenchymal stem cells, dental pulp stem cells, bone marrow stem cells, bone regeneration, calvarial defect

Organism: Rabbit

Tissue: Bone

494
Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis

HT Liu, TE Wang, YT Hsu, CC Chou, KH Huang, CC Hsu, HJ Liang, HW Chang, TH Lee, PS Tsai

Antioxidants (MDPI) Taiwan, 09 October 2019

Biological Materials

Key words: honokiol, cisplatin, kidney injury, oxidative stress, apoptosis, nanotechnology

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

495
Loss of smooth muscle CYB5R3 amplifies angiotensin II–induced hypertension by increasing sGC heme oxidation

BG Durgin, SA Hahn, HM Schmidt, MP Miller, N Hafeez, I Mathar, D Freitag, P Sandner, AC Straub

JCI insight (American Society of Clinical Investigation) Germany, USA, 03 October 2019

Cardiology

Key words: Vascular Biology, Guanylate cyclase, Hypertension, Nitric oxide

Organism: Mouse

Tissue: Heart, Blood Vessels

Pathological State: Hypertension

496
Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β1-42 Oligomers

LS Wang, X Tao, XM Liu, YF Zhou, MD Zhang, YH Liao, RL Pan, Q Chang

Frontiers in Pharmacology (Frontiers Media S.A.) China, 24 September 2019

Pharmacology

Organism: Mouse

Tissue: Brain

497
Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8

HC Wang, YL Lin, CC Hsu, YJ Chao, YC Hou, TJ Chiu, PH Huang, MJ Tang, LT Chen, YS Shan

Theranostics (NCBI) Taiwan, 23 September 2019

Oncology

Key words: pancreatic cancer, PSC, stiffness, organotypic coculture, PAI-1

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

498
A Method for Predicting the Success of Pulsinell's Four-Vessel Occlusion Rat Model by LDF Monitoring of Cerebral Blood Flow Decline

W Wang, X Liu, H Lu, L Liu, Y Wang, Y Yu, T Zhang

Journal of Neuroscience Methods (Elsevier) China, 20 September 2019

Neuroscience

Key words: Global cerebral ischemia-reperfusion injury, Laser Doppler flowmetry, Pulsinelli's four-vessel occlusion method, cerebral blood flow decline

Organism: Rat

Tissue: Brain

499
Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats

CY Chang, HJ Shih, IT Huang, PS Tsai, KY Chen, CJ Huang

International Journal of Molecular Sciences (MDPI) Taiwan, 18 September 2019

Cardiology

Key words: Right heart failure, oxidation, mitochondria, inflammation, inflammasomes, apoptosis

Organism: Rat

Tissue: Lung

Pathological State: Hypertension

500
Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model

S Hu, C Sun, B Wang, K Zhou, L Pan, J Shangguan, V Yaghmai, M Figini, Z Zhang

Journal of Vascular and Interventional Radiology (Elsevier) China, 18 September 2019

Oncology

Organism: Rabbit

Tissue: Liver

Pathological State: Cancer

501
Disruption of mitochondrial homeostasis with artemisinin unravels anti-angiogenesis effects via auto-paracrine mechanisms

KH Tsui, MY Wu, LT Lin, ZH Wen, YH Li, PY Chu, CJ Li

Theranostics (NCBI) Taiwan, USA, 17 September 2019

Endocrinology

Key words: artemisinin, mitochondria, VEGF, angiogenesis, auto-paracrine

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

502
Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation

A Quarta, D Le Blon, T D'aes, Z Pieters, SH Taj, F Miro-Mur, E Luyckx, E Van Breedam, J Daans, H Goossens, S Dewilde, N Hens, V Pasque, AM Planas, M Hoehn, Z Berneman, P Ponsaerts

Brain, Behavior, and Immunity (Elsevier) Belgium, Germany, Spain, The Netherlands, 13 September 2019

Immunology, Neuroscience

Key words: iPSC, Microglia, Macrophages, Stroke, Neuroinflammation, Interleukin (IL) 13, Polarisation, Classical activation, Alternative activation

Organism: Mouse

Tissue: Brain

503
The Effect of Wharton Jelly-Derived Mesenchymal Stromal Cells and Their Conditioned Media in the Treatment of a Rat Spinal Cord Injury

Milada Chudickova ,Irena Vackova ,Lucia Machova Urdzikova ,Pavlina Jancova ,Kristyna Kekulova ,Monika Rehorova ,Karolina Turnovcova ,Pavla Jendelova and Sarka Kubinova

International Journal of Molecular Sciences (MDPI) Czech Republic, 12 September 2019

Neuroscience

Key words: spinal cord injury, mesenchymal stem cells, Wharton’s jelly, conditioned medium, cell secretome, cell therapy

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

504
Next-generation computational tools for interrogating cancer immunity

F Finotello, D Rieder, H Hackl, Z Trajanoski

Nature Reviews Genetics (Nature) Austria, 12 September 2019

Oncology

Key words: Antigen presentation, Cancer genetics, Cancer genomics, Cancer immunotherapy, Computational biology and bioinformatics, Tumor immunology

505
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

X Wu, C Lei, T Xia, X Zhong, Q Yang, HB Shu

Nature communications (Nature) China, 11 September 2019

Immunology

Key words: Bacterial Infection, Innate immune cells, Pattern recognition receptors, Ubiquitylation

Organism: Mouse

Tissue: Lung

506
Region-specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation

G Gussak, A Pfenniger, L Wren, M Gilani, W Zhang, S Yoo, DA Johnson, A Burrell, B Benefield, G Knight, BP Knight, R Passman, JJ Goldberger, G Aistrup, JA Wasserstrom, Y Shiferaw, R Arora

JCI Insight (American Society of Clinical Investigation) USA, 10 September 2019

Neuroscience

Organism: Dog

Tissue: Heart

507
Region specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation

Georg Gussak, Anna Pfenniger, Lisa M. Wren, Mehul Gilani, Wenwei Zhang, Shin Yoo, David A. Johnson, Amy Burrell, Brandon Benefield, Gabriel M. Knight, Bradley P. Knight, Rod Passman, Jeffrey J. Goldberger, Gary Aistrup, J. Andrew Wasserstrom, Yohannes Shiferaw, and Rishi Arora

The Journal of Clinical Investigation (Am Soc Clin Investig) USA, 10 September 2019

Cardiology

Organism: Mouse

Tissue: Heart

508
Calcium‐sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice

Cheng Z, Li A, Tu CL, Santa Maria C, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W

Journal of Bone and Mineral Research (Wiley) USA, 09 September 2019

Osteology

Key words: chondrogenesis, osteogenesis, endochondral bone formation, cartilage, chondrocyte, osteoblast, CaSR knockout, unfixed fracture, fracture healing

509
Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection

J Kim, Y Moon

Nutrients (MDPI) South Korea, 08 September 2019

Immunology

Key words: Gut health, Probiotics, Caenorhabditis elegans, Epithelial barrier infection

Organism: Mouse

Tissue: Colon

Pathological State: Worm Infestation

510
Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation

BG Durgin, SA Hahn, HM Schmidt, MP Miller, N Hafeez, I Mathar, D Freitag, P Sandner, AC Straub

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, Germany, 05 September 2019

Cardiology

Organism: Mouse

Tissue: Heart

511
ATMIN is a tumor suppressor gene in lung adenocarcinoma

Hanna Foster, E. Josue Ruiz, Christopher Moore, Gordon W H Stamp, Emma L Nye, Ningning Li, Yihang Pan, Yulong He, Julian Downward, Axel Behrens

Cancer Research (AACR) UK, 03 September 2019

Oncology

512
Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer

TT Wei, YT Lin, SP Tang, CK Luo, CT Tsai, CT Shun, CC Chen

Oncogene (Nature) Taiwan, 02 September 2019

Oncology

Key words: Cancer therapeutic resistance, Tumor angiogenesis

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Cancer

513
Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models

M Lee, YS Kim, K Lee, M Kang, H Shin, JW Oh, H Koo, D Kim, Y Kim, DS Kong, DH Nam, H Won Lee

Cancers (MDPI) South Korea, 31 August 2019

Oncology

Key words: glioblastoma, patient-derived glioblastoma stem-like cells, semi- and pseudotyped-retroviral replicating vector, dual suicide gene therapy, bystander effect

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

514
The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain

E Nasyrov, KA Nolan, RH Wenger, HH Marti, R Kunze

The FASEB Journal (FASEB) Germany, Switzerland, 30 August 2019

Neuroscience

Key words: PHD, HIF, VEGF, Adrenomedullin, Cerebral angiogenesis

Organism: Mouse

Tissue: Brain

515
Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics

JWJ Ong, KS Tan, SG Ler, J Gunaratne, H Choi, JE Seet, VTK Chow

Cells (MDPI) Singapore, 26 August 2019

Pulmonology

Key words: influenza, pneumonia, lung regeneration, stem cells, comparative quantification, P63, KRT5, proliferating alveolar type II cells, proteomics

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

516
Macrophage HIF‐2α regulates tumor‐suppressive Spint1 in the tumor microenvironment

Rosa M. Susen, Rebekka Bauer, Catherine Olesch, Dominik C. Fuhrmann, Annika F. Fink, Nathalie Dehne, Arpit Jain, Ingo Ebersberger, Tobias Schmid, Bernhard Brüne

Molecular Carcinogenesis (Wiley) Germany, 22 August 2019

Oncology

Key words: HAI‐1, HGF, hypoxia, proliferation, tumor‐associated macrophages

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

517
Nononcogenic restoration of the intestinal barrier by E. coli–delivered human EGF

M Yu, J Kim, JH Ahn, Y Moon

The Journal of Clinical Investigation (Am Soc Clin Investig) South Korea, 22 August 2019

Microbiology

Organism: Mouse

Tissue: Small Intestine

Pathological State: Colitis

518
Microstimulation of primate neocortex targeting striosomes induces negative decision-making

S Amemori, K Amemori, T Yoshida, GK Papageorgiou, R Xu, H Shimazu, R Desimone, AM Graybiel

European Journal of Neuroscience (Wiley) USA, 20 August 2019

Neuroscience

Key words: anterior cingulate cortex, approach-avoidance, microstimulation, orbitofrontal cortex, striatum

Organism: Monkey

Tissue: Brain

519
Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity

Z Tang, S Cheng, Y Sun, Y Zhang, X Xiang, Z Ouyang, X Zhu, B Wang, M Hei

Experimental Neurology (Elsevier) China, 20 August 2019

Neuroscience

Key words: Hypoxia-ischemia(HI), Neuroprotection, Brain injuries, Hippocampus, Toll-like receptor 4, Rat model

Organism: Rat

Tissue: Brain

Pathological State: Hypoxic-Ischemic Brain Damage

520
IL‐10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis

JL Suen, Y Chang, YS Shiu, CY Hsu, P Sharma, CC Chiu, YJ Chen, TC Hour, EM Tsai

The Journal of Pathology (Wiley) Taiwan, 16 August 2019

Reproductive Medicine

Key words: Angiogenesis, Endometriosis, IL-10, Plasmacytoid dendritic cell, Zebrafish

Organism: Human, Mouse

Tissue: Endometrium

Pathological State: Endometriosis

521
Targeting the IL-17 receptor using liposomal spherical nucleic acids as topical therapy for psoriasis

H Liu, RS Kang, K Bagnowski, JM Yu, S Radecki, WL Daniel, BR Anderson, S Nallagatla, A Schook, R Agarwal, DA Giljohann, AS Paller

Journal of Investigative Dermatology (Elsevier) USA, 15 August 2019

Dermatology

Pathological State: Psoriasis

522
JAK‐STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression

Julian Mohrherr, Marcel Haber, Kristina Breitenecker, Petra Aigner, Stefan Moritsch, Viktor Voronin, Robert Eferl, Richard Moriggl, Dagmar Stoiber, Balázs Győrffy, Luka Brcic, Viktória László, Balázs Döme, Judit Moldvay, Katalin Dezső, Martin Bilban, Helmut Popper, Herwig P. Moll, Emilio Casanova

International Journal of Cancer (Wiley) Austria, Hungary, 12 August 2019

Oncology

Key words: non-small cell lung cancer, lung adenocarcinoma (AC), Kirsten rat sarcoma viral proto-oncogene (K-RAS), Janus kinase (JAK), ruxolitinib, cell-line derived xenografts, genetically engineered mouse models, tumor microenvironment (TME), tumor promotinginflammation

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

523
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway

P Guan, ZM Sun, N Wang, J Zhou, LF Luo, YS Zhao, ES Ji

Life Science (Elsevier) China, 11 August 2019

Cardiology

Key words: Resveratrol, Chronic intermittent hypoxia, Cardiac hypertrophy, mTOR

Organism: Rat

Tissue: Heart

Pathological State: Cardiac hypertrophy

524
Antibiotics drive microbial imbalance and vitiligo development in mice

Emilia R. Dellacecca, Cormac Cosgrove, Zhussipbek Mukhatayev, Suhail Akhtar, Victor H. Engelhard, Alfred W. Rademaker, Katherine Knight, I. Caroline Le Poole

Journal of Investigative Dermatology (Elsevier) USA, Kazakhstan, 09 August 2019

Dermatology

Key words: Vitiligo, Microbiome, Pseudomonas, T cells

Organism: Mouse

Tissue: Small Intestine, Colon

Pathological State: Vitiligo

525
Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys

S Taylor, K Pieri, P Nanni, J Tica, J Barratt, A Didangelos

Journal of Autoimmunity (Elsevier) UK, 09 August 2019

Immunology

Key words: IgA nephropathy (IgAN), PEBP4, Urine, Proteomics, Biomarker, B-Cells

Organism: Human

Tissue: Kidney

Pathological State: IgA nephropathy

526
Overexpression of Histone H3 Lysine 27 Trimethylation Is Associated with Aggressiveness and Dedifferentiation of Thyroid Cancer

CC Tsai, MN Chien, YC Chang, JJ Lee, SH Dai, SP Cheng

Endocrine Pathology (Springer) Taiwan, 08 August 2019

Oncology

Key words: H3K27me3, EZH2, Thyroid cancer, Immunohistochemistry

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

527
Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15

Y Guo, JL Ayers, KT Carter, T Wang, SK Maden, D Edmonds, PP Newcomb, C Li, C Ulrich, M Yu, WM Grady

Aging cell (Wiley) USA, 06 August 2019

Cell Biology

Key words: Colon organoids, Colorectal cancer, GDF15, microenivronment, senescence

Organism: Human

Tissue: Colon

Pathological State: Cancer

528
Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment

JY Chen, YS Lai, PY Chu, SH Chan, LH Wang, WC Hung

Cancers (MDPI) Taiwan, 06 August 2019

Oncology

Key words: vascular endothelial growth factor-C, CXC chemokine receptor 2, lymphovascular niche, myeloid-derived suppressor cells

Organism: Human

Tissue: Breast

Pathological State: Cancer

529
Analysis of Telomere Lengths in p53 Signatures and Incidental Serous Tubal Intraepithelial Carcinomas Without Concurrent Ovarian Cancer

S Asaka, C Davis, SF Lin, TL Wang, CM Heaphy, IM Shih

The American journal Surgical Pathology (Wolters Kluwer) USA, 01 August 2019

Oncology

Key words: ovarian cancer precursor, fallopian tube, p53 signature, serous tubal intraepithelial carcinoma, telomere

530
Increased ILC3s associated with higher levels of IL-1 aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

Tzu‐Yi Chan, Chia‐Liang Yen, Ya‐Fang Huang, Pei‐Chi Lo, Peter A. Nigrovic, Chia‐Ying Cheng, Wei‐Zhi Wang, Szu‐Yu Wu, Chi‐Chang Shieh

European Journal of Immunology (Wiley) Taiwan, Japan, USA, 26 July 2019

Rheumatology

Key words: Innate lymphoid cells, Chronic granulomatous disease, NADPH oxidase, Reactive oxygen species, Serum-induced arthritis

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Arthritis

531
Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns

Yung-Ning Yang, Yu-Chen S.H. Yang, I-Hsuan Lin, Ying-Yu Chen, Hung-Yun Lin, Chien-Yi Wu, Yu-Tsun Su, Yao-Jong Yang, San-Nan Yang, Jau-Ling Suen

Food and Chemical Toxicology (Elsevier) Taiwan, USA, 26 July 2019

Toxicology

Key words: Di-(2-ethylhexyl) phthalate, Intravenous infusion, Microbiota, Anti-HBsAg-IgM, Newborn

532
An Amyloid-β Targeting Chemical Exchange Saturation Transfer Probe for In Vivo Detection of Alzheimer's Disease

R Wang, C Wang, Z Dai, Y Chen, Z Shen, G Xiao, Y Chen, JN Zhou, Z Zhuang, R Wu

ACS Chemical Neuroscience (ACS Publications) China, 25 July 2019

Neuroscience

Key words: Alzheimer’s disease, Amyloid-β, Magnetic resonance imaging, Chemical exchange saturation transfer, Angiopep-2

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s disease

533
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci & Lucia Di Marcotullio

Nature Communications (Nature) Italy, France, USA, UK, 24 July 2019

Oncology

Key words: Cancer, Molecular biology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

534
Synergistic effect of NELL-1 and an ultra-low dose of BMP-2 on spinal fusion

Miss Ling Liu, Dr. Wing Moon Raymond Lam, Mrs. Mathanapriya Naidu Zheng Yang, Dr. Ming Wang, Dr. Xiafei Ren, Dr. Tao Hu, Kumarsing Amit Ramruttun, Prof. Kang Ting, Prof. James Cho-Hong Goh, Prof. Hee Kit Wong

Tissue Engineering Part A (Mary Ann Liebert Inc.) Singapore, China, 24 July 2019

Regenerative Medicine

Organism: Pig

Cell Line: BMSC

535
DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing

Huafeng Zhang, Songge Xing, Zhaoyong Li, Wenhao Ma, Xiaoping He, Shengqi Shen, Haoran Wei, Shi-Ting Li, Ying Shu, Linchong Sun, Xiuying Zhong, Yuhao Huangfu, Lanhong Su, Junru Feng, Xiaozhang Zhang, Ping Gao and Wei-Dong Jia

Cancer Research (AACR) China, 22 July 2019

Oncology

Key words: HCC, DIS3L2, hnRNP U, Alternative splicing, Rac1b

Organism: Human

Tissue: Liver

Pathological State: Cancer

536
Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus

I Simitsidellis, AE Zufiaurre, O Kelepouri, Elisabeth O’Flaherty, Douglas A. Gibson, Philippa T. K. Saunders

Journal of Endocrinology (bioscientifica) Ireland, 18 July 2019

Reproductive Medicine

Key words: Uterus, Endometrium, Androgen, SARM, Andarine, GTx-024, Enobosarm, 15 Ostarine, Danazol, DHT

Organism: Mouse

Tissue: Uterus

537
Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

CY Hung, TI Hsu, JY Chuang, TP Su, WC Chang, JJ Hung

Molecular Neurobiology (Springer) Taiwan, USA, 18 July 2019

Neuroscience

Key words: Sp1, Astrocyte, Neurite outgrowth, Synaptogenesis

Organism: Mouse

Tissue: Brain

538
Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction

Thomas M. Hofbauer, Andreas Mangold, Thomas Scherz, Veronika Seidl, Adelheid Panzenböck, Anna S. Ondracek, Julian Müller, Matthias Schneider, Thomas Binder, Lena Hell, Irene M. Lang

Basic research in Cardiology (Springer) Austria, 16 July 2019

Cardiology

Key words: ST-segment elevation myocardial infarction, Neutrophil extracellular traps, Fibrocytes Thrombosis

Organism: Human

Tissue: Heart

539
Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface

Caroline M. Weight, Cristina Venturini, Sherin Pojar, Simon P. Jochems, Jesús Reiné, Elissavet Nikolaou, Carla Solórzano, Mahdad Noursadeghi, Jeremy S. Brown, Daniela M. Ferreira & Robert S. Heyderman

Nature Communications (Nature) UK, 16 July 2019

Microbiology, Immunology

Key words: Infection, Innate immunity, Pathogens, Respiratory tract diseases

Organism: Human

Pathological State: Streptococcus pneumoniae infection

Cell Line: Mucosal cells

540
B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease

Emanuel Della-Torre, Elena Rigamonti, Cory Perugino, Simona Baghai-Sain, Na Sun, Naoki Kaneko, Takashi Maehara, Lucrezia Rovati, Maurilio Ponzoni, Raffaella Milani, Marco Lanzillotta, Vinay Mahajan, Hamid Mattoo, Ivan Molineris, Vikram Deshpande, j John H. Stone, Massimo Falconi, Angelo A. Manfredi, Shiv Pillai,

Journal of Allergy and Clinical Immunology (Elsevier) Italy, USA, Japan, 15 July 2019

Allergy Research

Key words: IgG4, IgG4-related disease, B cells, plasmablasts, fibrosis, fibroblasts, rituximab, lysyl oxidase homolog 2, plateletderived growth factor

Organism: Human

Tissue: Pancreas, Lymphoid Tissue,

Pathological State: Fibrosis

541
Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond

TB Steinbichler, D Savic, D Dejaco, A Romani, B Kofler, II Skvortsova, H Riechelmann, J Dudas

Cancer Microenvironment (Springer) Austria, 11 July 2019

Oncology

Key words: IL-6, EMT, JAK/STAT3/Snail signalling, radiochemotherapy, therapy resistance, conditioned medium

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

542
The Lymphoma-Associated Macrophages-To-Hodgkin-Reed-Sternberg Cells Ratio Is A Poor Prognostic Factor In Classic Hodgkin Lymphoma Patients

V Procházka, T Papajík, T Dýšková, M Dihel, S Brychtová, Z Prouzová, E Kriegová, M Lukášová, V Hanáčková

Clinical Lymphoma Myeloma and Leukemia (Elsevier) Czech Republic, 05 July 2019

Oncology

Key words: Hodgkin lymphoma, macrophage, prognosis, microenvironment

Organism: Human

Pathological State: Cancer

543
miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Hsin-Yi Chen, Yaw-Dong Lang, Han-Nan Lin, Yun-Ru Liu, Chun-Chieh Liao, André Wendindondé Nana, Yun Yen & Ruey-Hwa Chen

Scientific Reports (Nature) Taiwan, 04 July 2019

Oncology

Key words: Colon cancer, Metastasis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

544
Entrapment of N-Hydroxyphthalimide Carbon Dots in Different Topical Gel Formulations: New Composites with Anticancer Activity

CL Savin, C Tiron, E Carasevici, CS Stan, SA Ibanescu, BC Simionescu, CA Peptu

Pharmaceutics (MDPI) Romania, 01 July 2019

Oncology

Key words: composite, N-hydroxyphthalimide, carbon dots, polymer gels, antitumoral activity

Organism: Human

Cell Line: MDA-MB-231 cells

545
Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

Tetsuya Akiyama, Naoki Suzuki, Mitsuru Ishikawa, Koki Fujimori, Takefumi Sone, Jiro Kawada, Ryo Funayama, Fumiyoshi Fujishima, Shio Mitsuzawa, Kensuke Ikeda, Hiroya Ono, Tomomi Shijo, Shion Osana, Matsuyuki Shirota, Tadashi Nakagawa, Yasuo Kitajima, Ayumi Nishiyama, Rumiko Izumi, Satoru Morimoto, Yohei Okada, Takayuki Kamei, Mayumi Nishida, Masahiro Nogami, Shohei Kaneda, Yoshiho Ikeuchi, Hiroaki Mitsuhashi, Keiko Nakayama, Teruo Fujii, Hitoshi Warita, Hideyuki Okano, Masashi Aoki, Masashi Aoki

EBioMedicine (Elsevier) Japan, 29 June 2019

Neuroscience

Key words: Amyotrophic lateral sclerosis (ALS), Fused in sarcoma (FUS), Axon branching, Fos-B, Nerve organoid, Human-induced pluripotent stem cell (hiPSC)-derived motor neuron

Organism: Human

Tissue: Spinal Cord

Pathological State: ALS

546
Fbxw7 increases CCL2/7 in CX3CR1hi macrophages to promote intestinal inflammation

Jia He, Yinjing Song, Gaopeng Li, Peng Xiao, Yang Liu, Yue Xue, Qian Cao, Xintao Tu, Ting Pan, Zhinong Jiang, Xuetao Cao, Lihua Lai, and Qingqing Wang

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 27 June 2019

Immunology

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

547
Amelioration of Experimentally Induced Arthritis by Reducing Reactive Oxygen Species Production through the Intra-Articular Injection of Water-Soluble Fullerenol

WS Kuo, CT Weng, JH Chen, CL Wu, AL Shiau, JL Hsieh, EC So, PT Wu, SY Chen

Nanomaterials (MDPI) China, Taiwan, 23 June 2019

Nanomedicine

Key words: experimental arthritis, intra-articular injection, reactive oxygen species, rheumatoid arthritis, water-soluble fullerenol

Organism: Rat

Tissue: Bone, Connective Tissue

Pathological State: Arthritis

548
Cytotoxic T-cells and their activation status are independent prognostic markers in meningiomas

Carmen Rapp, Steffen Dettling, Fang Liu, Anna Theresa Ull, Rolf Warta, Christine Jungk, Saskia Roesch, Andreas Mock, Felix Sahm, Melissa Schmidt, Gerhard Jungwirth, Klaus Zweckberger, Katrin Lamszus, Konstaninos Gousias, Almuth F Kessler, Niels Grabe, Mario Löhr, Ralf Ketter, Steffi Urbschat, Christian Senft, Manfred Westphal, Amir Abdollahi, Jürgen Debus, Andreas von Deimling, Andreas Unterberg, Matthias Simon and Christel C Herold-Mende

Clinical Cancer Research (AACR) Germany, 21 June 2019

Immunology, Oncology

Key words: Clinically aggressive meningioma, T-cell infiltration, primary and recurrent tumors TILs, PD-1

Organism: Human

Tissue: Brain

Pathological State: Cancer

549
Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets

Barbara Thaler, Nagyung Baik, Philipp J. Hohensinner, Johanna Baumgartner, Adelheid Panzenböck, Stefan Stojkovic, Svitlana Demyanets, Ihor Huk, Gersina Rega-Kaun, Christoph Kaun, Manfred Prager, Michael B. Fischer, Kurt Huber, Walter S. Speidl, Robert J. Parmer, Lindsey A. Miles, Johann Wojta

Blood (American Society of Hematology) Austria, USA, 20 June 2019

Cardiology

Organism: Human

Tissue: Adipose Tissue

550
Specific inhibition of the classical complement pathway prevents C3 deposition along the dermal-epidermal junction in bullous pemphigoid

Patricia Colchete Freire, Cristina Herraez Muñoz, Ulla Derhaschnig, Christian Schoergenhofer, Christa Firbas, Graham C. Parry, Sandip Panicker, James C. Gilbert, Georg Stingl, Bernd Jilma, Peter Maximilian Heil

Journal of Investigative Dermatology (Elsevier) Austria, USA, 20 June 2019

Dermatology

551
Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

C Yang, P Sun, M Deng, P Loughran, W Li, Z Yi, S Li, XH Zhang, J Fan, TR Billar, MJ Scott

Cell Death & Disease (Nature) USA, China, 17 June 2019

Hepathology

Key words: Cell death and immune response, Innate immunity

Organism: Mouse

Tissue: Liver

Pathological State: Liver Injury

552
C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice

Tobias Ackermann, Götz Hartleben, Christine Müller, Guido Mastrobuoni, Marco Groth, Britt A. Sterken, Mohamad A. Zaini, Sameh A. Youssef, Hidde R. Zuidhof, Sara R. Krauss, Gertrud Kortman, Gerald de Haan, Alain de Bruin, Zhao-Qi Wang, Matthias Platzer, Stefan Kempa & Cornelis F. Calkhoven

Nature Communications Biology (Nature) The Netherlands, Germany, 14 June 2019

Oncology

Key words: Cancer metabolism, Cell growth

Organism: Mouse

Tissue: Bone Marrow

553
Fc glycan-mediated regulation of placental antibody transfer

Madeleine F. Jennewein, Ilona Goldfarb, Sepideh Dolatshahi, Cormac Cosgrove, Francesca J. Noelette, Marina Krykbaeva, Jishnu Das, Aniruddh Sarkar, Matthew J. Gorman, Stephanie Fischinger, Carolyn M. Boudreau, Joelle Brown, Jennifer H. Cooperrider, Jasneet Aneja, Todd J. Suscovich, Barney S. Graham, Georg M. Lauer, Tessa Goetghebuer, Arnaud Marchant, Douglas Lauffenburger, Arthur Y. Kim, Laura E. Riley, Galit Alter

CELL (Cell Press) USA, Belgium, 13 June 2019

Reproductive Medicine, Immunology

Key words: antibody functionality, antibody glycosylation, trans-placental transfer, maternal vaccination, ADCC, neonatal immunology

Organism: Human

Tissue: Placenta

554
The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism

RL Konger, E Derr-Yellin, N Ermatov, L Ren, RP Sahu

Molecules (MDPI) USA, 11 June 2019

Oncology, Immunology

Key words: peroxisome proliferator activated receptor gamma, rosiglitazone, T-cells, myeloid cells, anti-tumor immunity

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

555
Optimisation of multiplex immunofluorescence for a non-spectral fluorescence scanning system

CC Anyaegbu, TF Lee-Pullen, TJ Miller, TN Abel, CF Platell, MJ McCoy

Journal of Immunological Methods (Elsevier) Australia, 08 June 2019

Medical Imaging

Key words: Fluorescence microscopy, Imaging, Immunohistochemistry, T cells, Colorectal

Organism: Human

Tissue: Colon

556
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

Amanda Ardain, Racquel Domingo-Gonzalez, Shibali Das, Samuel W. Kazer, Nicole C. Howard, Alveera Singh, Mushtaq Ahmed, Shepherd Nhamoyebonde, Javier Rangel-Moreno, Paul Ogongo, Lan Lu, Duran Ramsuran, Maria de la Luz Garcia-Hernandez, Tyler K. Ulland, Matthew Darby, Eugene Park, Farina Karim, Laura Melocchi, Rajhmun Madansein, Kaylesh Jay Dullabh, Micah Dunlap, Nancy Marin-Agudelo, Takashi Ebihara, Thumbi Ndung’u, Deepak Kaushal, Alexander S. Pym, Jay K. Kolls, Adrie Steyn, Joaquín Zúñiga, William Horsnell, Wayne M. Yokoyama, Alex K. Shalek, Henrik N. Kløverpris, Marco Colonna, Alasdair Leslie & Shabaana A. Khader

Nature (Nature) South Africa, USA, Kenya, Mexico, UK, Denmark, 05 June 2019

Immunology

Key words: Innate lymphoid cells, Tuberculosis

Organism: Human

Tissue: Lung

Pathological State: Tuberculosis

557
Role of the PI3K‑mTOR autophagy pathway in nerve damage in rats with intermittent hypoxia‑aggravated whole brain ischemia

X Guo, Y Liu, Y Zhao, R Fan, Y Bai, X Guo, J Li, CX Chen

Molecular Medicine Reports (Spandidos Publications) China, 04 June 2019

Neuroscience

Organism: Rat

Tissue: Brain

Pathological State: Ischemia

558
Heat-killed Mycobacterium tuberculosis prime-boost vaccination induces myeloid-derived suppressor cells with spleen dendritic cell-killing capability

Eliana Ribechini, Ina Eckert, Andreas Beilhack, Nelita Du Plessis, Gerhard Walzl, Ulrike Schleicher, Uwe Ritter, and Manfred B. Lutz

The Journal of Clinical Investigation (American Society for Clinical Investigation) Germany, South Africa, 04 June 2019

Immunology

Organism: Mouse

Cell Line: BM-MDSCs and BM-DCs cell

559
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Yueming Zhu, Xianghui Zou, Angela E. Dean, Joseph O’ Brien, Yucheng Gao, Elizabeth L. Tran, Seong-Hoon Park, Guoxiang Liu, Matthew B. Kieffer, Haiyan Jiang, Melissa E. Stauffer, Robert Hart, Songhua Quan, Karla J. F. Satchell, Nobuo Horikoshi, Marcelo Bonini, David Gius

Nature Communications (Nature) USA, South Korea, 03 June 2019

Oncology

Key words: Breast cancer, Cancer, Enzyme mechanisms

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

560
Abnormal expression of b10 cell frequencies: possible relation to pathogenesis and disease severity of aplastic anemia

L Gu, B Fu, X Sui, H Xu

Revista da Associação Médica Brasileira (SciELO Brasil) China, 03 June 2019

Hematology

Key words: Anemia, Aplastic, B-Lymphocytes, Regulatory, Interleukin-10

Organism: Human

Cell Line: Bone marrow-derived mononuclear cells

561
Micro RNA‐133 Suppresses ZFHX 3‐dependent Atrial Remodeling and Arrhythmia

WL Cheng, YH Kao, TF Chao, YK Lin, SA Chen, YJ Chen

Acta Physiologica (Wiley) Taiwan, 01 June 2019

Cardiology

Key words: atrial ectopy, cardiac remodelling, connexin43, MicroRNA‐133, Wnt/calcium signalling, ZFHX3

Organism: Mouse

Tissue: Heart

Pathological State: Arrhythmia

562
AIF-regulated oxidative phosphorylation supports lung cancer development

Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J. Cronin, Zhigang She, Franz Quehenberger, Helmut Popper, Lukas Kenner, Jody J. Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer & Josef M. Penninger

Cell Research (Nature) China, Austria, France, Germany, Canada, Belgium, Sweden, 27 May 2019

Oncology

Key words: Mechanisms of disease, Non-small-cell lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

563
Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

H Tsugawa, C Kato, H Mori, J Matsuzaki, K Kameyama, H Saya, M Hatakeyama, M Suematsu, H Suzuki

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) Japan, 27 May 2019

Oncology, Microbiology

Key words: Autophagy, CagA, Cancer Stem Cells, CD44v9, Eradication Therapy

Organism: Human

Tissue: Stomach

Pathological State: Cancer

564
LINGO-1 deficiency promotes nerve regeneration through reduction of cell apoptosis, inflammation, and glial scar after spinal cord injury in mice

LJ Huang, G Li, Y Ding, JH Sun, TT Wu, W Zhao, YS Zeng

Experimental Neurology (Elsevier) China, 25 May 2019

Neuroscience

Key words: LINGO-1 knockout, Spinal cord injury, Cell apoptosis, Inflammation, Glial scar, Nerve regeneration

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

565
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

Matthew K.Tobin, Kianna Musaraca, Ahmed Disouky, Aashutosh Shetti, Abdullah Bheri, William G.Honer, Namhee Kim, Robert J. Dawe, David A. Bennett, Konstantinos Arfanakis, Orly Lazarov

Cell Stem Cell (Cell Press) USA, 23 May 2019

Neuroscience

Key words: human neurogenesis, adult neurogenesis, neural stem cells, neurogenesis in aging, cognitive dysfunction, aging, Alzheimer’s disease

Organism: Human

Tissue: Brain

Pathological State: Alzheimer's Disease

566
Near-Infrared Fluorescent Endoscopic Image-guided Photothermal Ablation Therapy of Colorectal Cancer using Dual-modal Gold Nanorods Targeting Tumor Infiltrating Innate Immune Cells in Transgenic TS4 CRE/APCloxΔ468 Mouse Model

Elias Gournaris, Wooram Park, Soojeong Cho, David J Bentrem, Andrew C. Larson, Dong-Hyun Kim

ACS Applied Materials and Interfaces (ACS Publications) USA, 22 May 2019

Oncology

Key words: colon cancer, endoscopic image-guided therapy, nanomedicine, interventional oncology, photothermal therapy

Organism: Mouse

Tissue: Colon

Pathological State: Polyps

567
High Activation Of STAT5A Drives Peripheral T-Cell Lymphoma And Leukemia

Barbara Maurer, Harini Nivarthi, Bettina Wingelhofer, Ha Thi Than Pham, Michaela Schlederer, Tobias Suske, Reinhard Grausenburger, Ana-Iris Schiefer, Michaela Prchal-Murphy, Doris Chen, Susanne Winkler, Olaf Merkel, Christoph Kornauth, Maximilian Hofbauer, Birgit Hochgatterer, Gregor Hoermann, Andrea Hoelbl-Kovacic, Jana Prochazkova, Cosimo Lobello, Abbarna A. Cumaraswamy, Johanna Latzka, Melitta Kitzwögerer, Andreas Chott, Andrea Janikova, Šárka Pospíšilova, Joanna I. Loizou, Stefan Kubicek, Peter Valent, Thomas Kolbe, Florian Grebien, Lukas Kenner, Patrick T. Gunning, Robert Kralovics, Marco Herling, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard Moriggl

Haematologica (The Ferrata Sorti Foundation) Austria, Czech Republic, Germany, Canada, 21 May 2019

Oncology

Key words: Hematopoiesis, Lymphocytes, Lymphoproliferative Disorders, PTCLSTAT5

Organism: Mouse

Tissue: Lymphoid Tissue

Pathological State: Cancer

568
The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury

Barbora Svobodova, Anna Kloudova, Jiri Ruzicka, Ludmila Kajtmanova, Leos Navratil, Radek Sedlacek, Tomas Suchy, Meena Jhanwar-Uniyal, Pavla Jendelova & Lucia Machova Urdzikova

Scientific Reports (Nature) Czech Republic, USA, 21 May 2019

Regenerative Medicine

Key words: Spinal cord diseases, Spinal cord injury

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

569
Growth and cellular patterning during fetal human inner ear development studied by a correlative imaging approach

Lejo Johnson Chacko, David Wertjanz, Consolato Sergi, Jozsef Dudas, Natalie Fischer, Theresa Eberharter, Romed Hoermann, Rudolf Glueckert, Helga Fritsch, Helge Rask-Andersen, Anneliese Schrott-Fischer and Stephan Handschuh

BMC Developmental Biology (Springer) Austria, 20 May 2019

Developmental Biology

Organism: Human

Tissue: Bone

570
Nano-formulated Curcumin (LipodisqTM) modulates the local inflammatory response, reduces glial scar and preserves the white matter after spinal cord injury in rats

P Krupa, B Svobodova, J Dubisova, S Kubinova, P Jendelova, L Machova Urdzikova

Neuropharmacology (Elsevier) Czech Republic, 17 May 2019

Nanomedicine

Key words: Spinal cord injury, Nanocurcumin, Inflammatory response, Neuroregeneration, Astrogliosis, Axonal growth

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

571
Amentoflavone Effectively Blocked the Tumor Progression of Glioblastoma via Suppression of ERK/NF-B Signaling Pathway

FT Hsu, IT Chiang, YC Kuo, TC Hsia, CC Lin, YC Liu, JG Chung

The American Journal of Chinese Medicine (World Scientific) Taiwan, 17 May 2019

Oncology

Key words: Amentoflavone, Glioblastoma, Anticancer, ERK, NF-κB

Organism: Mouse

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

572
Potential Effects of CXCL9 and CCL20 on Cardiac Fibrosis in Patients with Myocardial Infarction and Isoproterenol-Treated Rats

CF Lin, CJ Su, JH Liu, ST Chen, HL Huang, SL Pan

Journal of Clinical Medicine (MDPI) Taiwan, 11 May 2019

Cardiology

Key words: myocardial infarction, cardiac fibrosis, CXCL9, CCL20, isoproterenol

Organism: Rat

Tissue: Heart

Pathological State: Cardiac Fibrosis

573
In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field

PW Nagle, MJ van Goethem, M Kempers, H Kiewit, A Knopf, JA Langendijk, S Brandenburg, P van Luijk, RP Coppes

Radiotherapy and Oncology (Elsevier) The Netherlands, 11 May 2019

Oncology

Key words: Protons, MRI, Tumor, Normal tissue, Organoids

Organism: Human

Cell Line: Human embryonic kidney cells (HEK293) and human lung adenocarcinoma cells (A549)

574
Effects of Hydroxychloroquine on the Human Placenta–Findings from In Vitro Experimental Data and a Systematic Review

RE Scott, SL Greenwood, DJL Hayes, BC Baker, RL Jones, AEP Heazell

Reproductive Toxicology (Elsevier) UK, 10 May 2019

Reproductive Medicine

Key words: Hydroxychloroquine, Placenta, TLRs, TLR 7, TLR 9, Inflammation, Toxicology, Safety, Pregnancy, SLEAPS

Organism: Human

Tissue: Placenta

575
Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

Kimberly M. Cirelli, Diane G. Carnathan, Bartek Nogal, Jacob T. Martin, Oscar L. Rodriguez, Amit A. Upadhyay, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Federico Viviano, Catherine Nakao, Matthias G. Pauthner, Samantha Reiss, Christopher A. Cottrell, Melissa L. Smith, Raiza Bastidas, William Gibson, Amber N. Wolabaugh, Mariane B. Melo, Benjamin Cossette, Venkatesh Kumar, Nirav B. Patel, Talar Tokatlian, Sergey Menis, Daniel W. Kulp, Dennis R. Burton, Ben Murrell, William R. Schief, Steven E. Bosinger, Andrew B. Ward, Corey T. Watson, Guido Silvestri, Darrell J. Irvine, Shane Crotty

CELL (Cell Press) USA, Sweden, 09 May 2019

Immunology

Key words: HIV vaccine, non-human primates, rhesus macaque genome, FNA, GC- TFH, memory B cells, somatic hypermutation, affinity maturation, immune complexes

Organism: Mouse

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

576
Multimodal [18F]FDG PET/CT is a direct readout for inflammatory bone repair: a longitudinal study in TNFα transgenic mice

Silvia Hayer, Markus Zeilinger, Volker Weiss , Monika Dumanic , Markus Seibt , Birgit Niederreiter ,Tetyana Shvets , Florian Pichler ,Wolfgang Wadsak , Bruno K. Podesser, Thomas H. Helbich, Marcus Hacker, Josef S. Smolen, Kurt Redlich , Markus Mitterhauser

Journal of Bone and Mineral Research (Wiley) Austria, 07 May 2019

Osteology

Key words: µPET/CT, 18F‐FDG, 18F‐NaF, bone healing, experimental arthritis, TNF blockade

Organism: Human

Tissue: Bone, Connective Tissue

577
Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis

GR Liguori, Q Zhou, TTA Liguori, GG Barros, PT Kühn, LF Moreira, P van Rijn, MC Harmsen

Stem Cells International (Hindawi Publishing Corporation) The Netherlands, Brazil, China, 05 May 2019

Stem Cell Research

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

578
CD11b+ cells markedly express the itch cytokine interleukin‐31 in polymorphic light eruption

V Patra, J Strobl, A Gruber‐Wackernagel, P Vieyra-Garcia, G Stary, P wolf

British Journal of Dermatology (Wiley) Austria, 03 May 2019

Dermatology

Organism: Human

Tissue: Skin

579
Endoplasmic reticulum stress is involved in stress-induced hypothalamic neuronal injury in rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK pathways

S Yi, K Chen, L Zhang, W Shi, Y Zhang, S Niu, M Jia, B Cong, Y Li

Frontiers in cellular Neuroscience (Frontiers Media S.A.) China, 03 May 2019

Neuroscience

Key words: hypothalamus, stress, neuronal injury, PERK-ATF4-CHOP pathway, IRE1-ASK1-JNK pathway

Organism: Rat

Tissue: Brain

Pathological State: Stress-Induced Hypothalamic Neuronal Injury

580
Positive PD‑L1 expression is predictive for patients with advanced EGFR wild‑type non‑small cell lung cancer treated with gemcitabine and cisplatin

Y Qiu, J Jiang, M Zhang, Y Qin

Oncology Letters (Spandidos Publications) China, 02 May 2019

Oncology

Key words: programmed death ligand-1, checkpoint, immunotherapy, non-small cell lung cancer, prognosis

Organism: Human

Tissue: Lung

Pathological State: Cancer

581
Exosomal transfer of bone marrow mesenchymal stem cells-derived miR340 attenuates endometrial fibrosis

B Xiao, Y Zhu, J Huang, T Wang, F Wang, S Sun

Biology Open (The Company of Biologists) China, 01 May 2019

Stem Cell Research

Organism: Rat

Tissue: Uterus

Pathological State: Endometriosis

582
An improved method of culturing somatotropic cells from rat adenohypophysis

J Mao, Y Bao, F Mei, X Liao, F Liu, L Zhou, B Qiu, S Qi

Tissue and Cell (Elsevier) China, 30 April 2019

Biological Methods

Key words: Pericytes, Improved method, Primary culture, Somatotropic cells

Organism: Rat

Cell Line: Pericytes

583
Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

HC Lin, YH Ching, CC Huang, PC Pao, WC Chang, TJ Kao, YC Lee

Journal of Biomedical Science (Springer) Taiwan, 26 April 2019

Neuroscience

Key words: Promyelocytic leukemia zinc finger, Plzf, luxoid mice, Cortical neuron

Organism: Mouse

Tissue: Brain

584
Wound Age Estimation by Neutrophil Migration Distance.

QQ Liu, HM Guo, L Wang, HL Lu, QX Du, RF Bai, JH Sun, YY Wang

Fa yi xue za zhi (Europe PMC) China, 25 April 2019

Immunology

585
Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production

HW Liao, TH Huang, YH Chang, HH Liou, YH Chou, YM Sue, PH Hung, YT Chang, PC Ho, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan, 25 April 2019

Osteology, Nephrology

Key words: exercise, chronic kidney disease, osteoporosis, sclerostin, chronic kidney disease–mineral bone disorder

Organism: Rat

Tissue: Bone

Pathological State: Kidney Disease

586
Th2-TRMs maintain life-long allergic memory in experimental asthma in mice

B Bosnjak, S Kazemi, LM Altenburger, G Mokrovic, MM Epstein

Frontiers in Immunology (Frontiers Media S.A.) Austria, 24 April 2019

Immunology

Organism: Mouse

Tissue: Lung

Pathological State: Asthma

587
YWHAE promotes proliferation, metastasis, and chemoresistance in breast cancer cells

YF Yang, YC Lee, YY Wang, CH Wang, MF Hou, SS Yuan

Kaohsiung journal of Medical Sciences (Wiley) Taiwan, 18 April 2019

Oncology

Key words: 14‐3‐3ε, breast cancer, chemoresistance, YWHAE

Organism: Human

Tissue: Breast

Pathological State: Cancer

588
Toll‑like receptor 4 plays a tumor‑suppressive role in cutaneous squamous cell carcinoma

Erina Mikami, Mitsuhiro Kudo, Ryuji Ohashi, Kiyoko Kawahara, Yoko Kawamoto, Kiyoshi Teduka, Takenori Fujii, Taeko Kitamura, Shoko Kure, Kousuke Ishino, Takashi Sakatani, Ryuichi Wada, Hidehisa Saeki, Zenya Naito

International Journal of Oncology (Spandidos Publications) Japan, 17 April 2019

Oncology

Key words: Toll-like receptor 4, cutaneous squamous cell carcinoma, differentiation, CD44, migration, invasion, filopodia

Organism: Human

Tissue: Skin

Pathological State: Cancer

589
Functional CD3+ CD8+ PD-1-T cells accumulation and PD-L1 expression increases during tumor invasion in DCIS of the breast

S Lv, S Wang, G Qiao, X Wang, X Zhou, F Yan, Y Li, S Wang, MA Morse, A Hobeika, J Ren, HK Lyerly

Clinical Breast Cancer (Elsevier) China, USA, 16 April 2019

Oncology

Key words: DCIS, Opal technique PDl-1, PD-1, immune, microenvironment

Organism: Human

Tissue: Breast

Pathological State: Cancer

590
Low cd8+ t cell infiltration and high pd-l1 expression are associated with level of cd44+/cd133+ cancer stem cells and predict an unfavorable prognosis in pancreatic cancer

YC Hou, YJ Chao, MH Hsieh, HL Tung, HC Wang, YS Shan

Cancers (MDPI) Taiwan, 15 April 2019

Oncology

Key words: pancreatic cancer, T cells, cancer stem cells, CD8, PD-L1, CD44, CD133, immunotherapy

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

591
Metastatic Colorectal Cancer Rewrites Metabolic Program Through a Glut3-YAP-dependent Signaling Circuit

CC Kuo, HH Ling, MC Chiang, CH Chung, WY Lee, CY Chu, YC Wu, CH Chen, YW Lai, IL Tsai, CH Cheng, CW Lin

Theranostics (Ivyspring) Taiwan, 13 April 2019

Oncology

Key words: cancer metabolism, colorectal cancer, glucose transporter, metastasis, YAP

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

592
Interrelations of Sphingolipid and Lysophosphatidate Signaling With Immune System in Ovarian Cancer

Anastasia Meshcheryakova, Martin Svoboda, Markus Jaritz, Felicitas Mungenast, Martina Salzmann, Dietmar Pils, Dan Cacsire Castillo-Tong, Gudrun Hager, Andrea Wolf, Elena Ioana Braicu, Jalid Sehouli, Sandrina Lambrechts, Ignace Vergote, Sven Mahner, Peter Birner, Philip Zimmermann, David N. Brindley, Georg Heinze, Robert Zeillinger, Diana Mechtcheriakova

Computational and Structural Biotechnology Journal (Elsevier) Austria, Germany, Belgium, Switzerland, Canada, 10 April 2019

Oncology

Key words: Sphingolipid/lysophosphatidate system, On-site immune response, Patient-specific expression data sets, Integrative analysis algorithm, Patient stratification, From systems biology to systems medicine

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

593
Au Nanoparticles with Enzyme-Mimicking Activities Ornamented ZIF-8 for Highly Efficient Photodynamic Therapy

Y Ma, Y Zhu, XF Tang, L Hang, W Jiang, M Li, M Khan, YZ You, YC Wang

Biomaterials Science (Royal Society of Chemistry) China, 04 April 2019

Nanomedicine

Key words: AuNPs nanozyme, nano metal-organic frameworks, tumor hypoxia, photodynamic therapy

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

594
Associations between hepatitis etiology and immune cell infiltration in or around hepatocellular carcinoma

Yu-Yun Shao, Min-Shu Hsieh, Yun-Ting Tsai, Ying-Chun Shen, Zhong-Zhe Lin, Ann-Lii Cheng, Chih-Hung Hsu

Cancer Research (AACR) USA, 03 April 2019

Oncology, Virology

Organism: Human

Tissue: Liver

Pathological State: Cancer

595
The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats

Hsiang-Chun Lee, Yi-Lin Shiou, Shih-Jie Jhuo, Chia-Yuan Chang, Po-Len Liu, Wun-Jyun Jhuang, Zen-Kong Dai, Wei-Yu Chen, Yun-Fang Chen and An-Sheng Lee

Cardiovascular Diabetology (Springer) Taiwan, 01 April 2019

Cardiology

Key words: SGLT2 inhibitor Empagliflozin Hypertensive Heart failure Cardiac fibrosis Hemodynamics High-fat PPARα ACADM

Organism: Rat

Tissue: Heart

Pathological State: Fibrosis

596
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells

Miroslav Boudny, Jana Zemanova, Prashant Khirsariya, Marek Borsky, Jan Verner, Jana Cerna, Alexandra Oltova, Vaclav Seda, Marek Mraz, Josef Jaros, Zuzana Jaskova, Michaela Spunarova, Yvona Brychtova, Karel Soucek, Stanislav Drapela, Marie Kasparkova, Jiri Mayer, Kamil Paruch, Martin Trbusek

Haematologica (Ferrata Storti Foundation) Czech Republic, 01 April 2019

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

597
Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells

TT Huang, YW Lan, CM Chen, YF Ko, DM Ojcius, J Martel, JD Young, KY Chong

Scientific Reports (Nature) Taiwan, USA, Malaysia, 26 March 2019

Oncology

Key words: Drug development, Lung cancer

Organism: Mouse

Tissue: Lung

598
PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma

Yong Jae Shin, Jason K. Sa, Yeri Lee, Donggeon Kim, Nakho Chang, Hee Jin Cho, Miseol Son, Michael Y.T. Oh, Kayoung Shin, Jin-Ku Lee, Jiwon Park, Yoon Kyung Jo, Misuk Kim, Patrick J. Paddison, Vinay Tergaonkar, Jeongwu Lee , Do-Hyun Nam

Journal of Experimental Medicine (Rockefeller University Press) South Korea, China, USA, 21 March 2019

Oncology, Cell Biology

Key words: Solid Tumors, Neuroscience

Organism: Human

Tissue: Brain

Pathological State: Cancer

599
Designing pH-Triggered Drug Release Iron Oxide Nanocomposites for MRI Guided Photothermal-Chemoembolization Therapy of Liver Orthotopic Cancer

F Liu, X Li, Y Li, Y Qi, H Yuan, J He, W Li, M Zhou

Biomaterials Science (Royal Society of Chemistry) China, 19 March 2019

Nanomedicine

Key words: pH-Triggered Drug Release, Iron Oxide Nanocomposites, MRI, Photothermal-Chemoembolization Therapy, Liver Orthotopic Cancer

Organism: Rat

Tissue: Liver

Pathological State: Cancer

600
γδT cells suppress liver fibrosis via strong cytolysis and enhanced NK cell-mediated cytotoxicity against hepatic stellate cells

M Liu, Y Hu, Y Yuan, Z Tian, C Zhang

Frontiers in Immunology (Frontiers Media S.A.) China, Germany, Belgium, USA, 15 March 2019

Immunology

Key words: fibrosis, γδT cell, NKp46, cytotoxicity, γδT1, γδT17, CD137, cell crosstalk

Organism: Mouse

Tissue: Liver

Pathological State: Fibrosis

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