Customer Publications (A total of 3161 papers published)

Construction of an infectious clone for enterovirus A89 and mutagenesis analysis of viral infection and cell binding

J Yan, M Wang, X Li, J Fan, R Yu, M Kang, Y Zhang, J Xu, X Zhang, S Zhang

Microbiology Spectrum (American Society for Microbiology) China, 05 March 2024

Virology

Key words: enterovirus A89; infectious clone; reverse genetics; site mutations; subgenomic replicon [more]

Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression

F Khan, Y Lin, H Ali, L Pang, M Dunterman, WH Hsu, K Frenis, RG Rowe, DA Wainwright, K McCortney, LK Billingham, J Miska, C Horbinski, MS Lesniak, P Chen

Nature Communications (Nature) USA, 05 March 2024

Oncology

Key words: Cancer metabolism, Caner microenvironment, Monocytes and macrophages [more]

Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial-Mesenchymal Transition

L Fang, L Zhang, M Wang, Y He, J Yang, Z Huang, Y Tan, K Fang, J Li, Z Sun, Y Li, Y Tang, W Liang, H Cui, Q Zhu, Z Wu, Y Li, Y Hu, W Chen

Cancer Research (AACR) China, 04 March 2024

Oncology

[more]

FUSeg: The foot ulcer segmentation challenge

C Wang, A Mahbod, I Ellinger, A Galdran, S Gopalakrishnan, J Niezgoda, Z Yu

Information (MDPI) USA, Austria, UK, 01 March 2024

Bioimaging

Key words: semantic segmentation, chronic wounds, foot ulcers, wound segmentation, challenge, benchmark

Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition

YT Huang, YT Hsu, PY Wu, YM Yeh, PC Lin, KF Hsu, MR Shen

Journal of Experimental & Clinical Cancer Research (Springer) Taiwan, 01 March 2024

Oncology

Key words: Cingulin, Rac1, IQGAP1, Epithelial-mesenchymal transition, Cancer-predisposing variant [more]

Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis.

NS Dey, S Senaratne, V Somaratne, NP Madarasinghe, B Seneviratne, S Forrester, MMd Oca, LC Reis, S Moulik, PB Walrad, M Chatterjee, H Goto, R Wickremasinghe, D Lagos, PM Kaye, S Ranasinghe

The Journal of Clinical Investigation (American Society for Clinical Investigation) UK, Sri Lanka, Brazil, India, 01 March 2024

Dermatology

[more]

Nicotinamide phosphoribosyltransferase modulates PD-L1 in bladder cancer and enhances immunotherapeutic sensitivity

KC Chen, T Dhar, CR Chen, ECY Chen, CC Peng

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Taiwan, 29 February 2024

Oncology

Key words: Bladder cancer (BLCA); NAMPT (nicotinamide phosphoribosyltransferase); PD-L1 (programmed death ligand 1); Tumor microenvironment (TME). [more]

Triple‐negative breast cancer survival prediction using artificial intelligence through integrated analysis of tertiary lymphoid structures and tumor budding

X Hou, X Li, Y Han, H Xu, Y Xie, T Zhou, T Xue, X Qian, J Li, HC Wang, J Yan, X Guo, Y Liu, J Liu

Cancer (Wiley) China, 29 February 2024

Oncology

Key words: artificial intelligence, nomogram, tertiary lymphoid structures, triple-negative breast cancer, tumor budding [more]

Inhibition of P2X7R alleviates neuroinflammation and brain edema after traumatic brain injury by suppressing the NF-κB/NLRP3 inflammasome pathway

B Tao, J Pei, H Li, G Yang, X Shi, Z Zhang, H Wang, Z Zheng, Y Liu, J Zhang

Journal of Neurorestoratology (Elsevier) China, 29 February 2024

Neuroscience

Key words: Traumatic brain injury, Neuroinflammation, Brain edema, P2X7R, NF-κB, NLRP3 [more]

Immune microenvironment heterogeneity of concurrent adenocarcinoma and squamous cell carcinoma in multiple primary lung cancers

J Zhang, Y Huang, Y Han, D Dong, Y Cao, X Chen, D Liu, X Cheng, D Sun, H Li, Y Zhang

NPJ Precision Oncology (Nature) China, 29 February 2024

Oncology

Key words: Cnacer genomics, Cancer microenvironment, Non-small-cell lung cancer, Tumour immunology [more]

Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5

L Ding, Y Sun, Y Liang, J Zhang, Z Fu, C Ren, P Li, W Liu, R Xiao, H Wang, Z Zhang, X Yue, C Li, Z Wu, Y Feng, X Liang, C Ma, L Gao

Advanced Science (Wiley) China, 28 February 2024

Endocrinology

Key words: Gαs ubiquitination; Tipe1; deubiquitinase USP5; diabetes; islet β cell [more]

TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis

Y Li, S Luan, C Ruan, W Li, X Zhang, Z Ran, W Bi, Y Tong, L Gao, J Zhao, Y Li, Z He

Biochemical and Biophysical Research Communications (Elsevier) China, 28 February 2024

Neuroscience

Key words: Thyroid-stimulating hormone receptor (TSHR); Memory; Cognitive impairment; Wnt5a; Neurogenesis [more]

Peripheral neural interfaces: Skeletal muscles are hyper-reinnervated according to the axonal capacity of the surgically rewired nerves

V Tereshenko, DC Dotzauer, M Schmoll, L Harnoncourt, GC Rojas, L Gfrerer, KR Eberlin, WG Austen Jr., R Blumer, D Farina, OC Aszmann

Science Advances (Science) USA, Austria, UK, 28 February 2024

Neuroscience

[more]

Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice

J Hu, K He, Y Yang, C Huang, Y Dou, H Wang, G Zhang, J Wang, C Niu, G Bi, L Zhang, S Zhu

Cell Reports (Cell Press) China, 26 February 2024

Neuroscience, Nutritional science

Key words: CP: Microbiology; CP: Neuroscience; amino acid formula; depression; microbiota. [more]

Combined inhibition of HER2 and VEGFR synergistically improves therapeutic efficacy via PI3K-AKT pathway in advanced ovarian cancer

W Li, K Zhang, W Wang, Y Liu, J Huang, M Zheng, L Li, X Zhang, M Xu, G Chen, L Wang, S Zhang

Journal of Experimental & Clinical Cancer Research (Springer) China, 26 February 2024

Oncology

Key words: HER2, VEGFR, Antibody drug conjugate, RC48, Cediranib Maleate, Synergetic effect, Ovarian cancer [more]

Negative impact of ratio of the microvascular area to tumor area on the response to EGFR-TKI in non-small cell lung cancer with an EGFR mutation

M Anai, K Saruwatari, K Imamura, K Fujino, T Jodai, S Sakata, S Iyama, Y Tomita, S Saeki, H Ichiyasu, K Ikeda, M Suzuki, T Sakagami

Journal of Thoracic Disease (AME) Japan, 26 February 2024

Oncology

Key words: Non-small cell lung cancer (NSCLC), epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), microvascular area, microvascular density (MVD) [more]

Use of Atrial Fibrillation Electrograms and T1/T2 Magnetic Resonance Imaging to Define the Progressive Nature of Molecular and Structural Remodeling: A New Paradigm Underlying the Emergence of Persistent Atrial Fibrillation

M Rottmann, S Yoo, A Pfenniger, A Mikhailov, B Benefield, DA Johnson, W Zhang, AK Ghosh, D Kim, R Passman, BP Knight, DC Lee, R Arora

Journal of the American Heart Association (American Heart Association) USA, 23 February 2024

Cardiology

Key words: MRI; arrhythmias; atrial fibrillation; fibrosis; mapping; reactive oxygen species [more]

Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice

Q Wu, Q Ren, X Wang, H Bai, D Tian, G Gao, F Wang, P Yu, YZ Chang

CNS Neuroscience & Therapeutics (Wiley) China, 22 February 2024

Neuroscience

Key words: Per1; aging; circadian rhythm; clock genes; iron [more]

RBM3 Promotes Anti-inflammatory Responses in Microglia and Serves as a Neuroprotective Target of Ischemic Stroke

J Zhao, S Liu, K Li, Y Yang, Y Zhao, X Zhu

Molecular Neurobiology (Springer) China, 22 February 2024

Neuroscience

Key words: Ischemic stroke, Cold-inducible RNA-binding proteins, Small molecule zr17-2, Neuroprotection, Neuroinflammation, Microglia [more]

NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis

CY Lin, KT Lee, YY Lin, CH Tsai, CY Ko, YC Fong, SM Hou, WL Chen, CC Huang, CH Tang

International Immunopharmacology (Elsevier) Taiwan, 21 February 2024

Neuroscience

Key words: NGF; Rheumatoid arthritis; ICAM-1; M1 macrophage; TrkA [more]

Tumor histoculture captures the dynamic interactions between tumor and immune components in response to anti-PD1 in head and neck cancer

NP Basak, K Jaganathan, B Das, O Muthusamy, R M, R Malhotra, A Samal, M Nath, G MS, AP Shankar, P BV, V Pillai, M BV, J C, V K, GS K, S Govindan, S V, Jy, K R, C Bhowal, U Kumar, G K, M Malhotra, S Sankaran

Nature Communications (Nature) India, 21 February 2024

Oncology, Immunology

Key words: Cancer models, Head and neck cancer, Tumour immunology [more]

CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma

S Wei, Y Zhang, BE Kang, W Park, H Guo, S Nam, JS Kang, JH Jeong, Y Jo, D Ryu, Y Jiang, KT Ha

BMB Reports () China, South Korea, 20 February 2024

Oncology

Key words: Clinical biomarker, Cyclin-dependent kinase inhibitor 2, Hepatocellular carcinoma, T cell exhaustion, Tissue microarray

TIMP3/Wnt axis regulates gliosis of Müller glia

JH Hung, PH Tsai, WJF Aala, CC Chen, SH Chiou, TW Wong, KJ Tsai, SM Hsu, LW Wu

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Taiwan, 17 February 2024

Ophthalmology

Key words: Müller cell; Müller glia; Gliosis; Age-related macular degeneration (AMD); Laser-induced choroidal neovascularization (CNV); Proliferative diabetic retinopathy (PDR) [more]

Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model

YC Shyu, TS Huang, HS Chiu, P Sumazin, XY Lin, PC Liao, CC Liou, FC Hsu, JS Lin, CC Hsu, PH Hsu, CC Sun, CT Chen

International Journal of Molecular Science (MDPI) Taiwan, USA, 17 February 2024

Regenerative Medicine

Key words: negative pressure wound therapy (NPWT); dickkopf-related-protein1 (DKK-1); hair follicle stem cells (HFSCs); epidermal cells; inflammatory [more]

CXCR5+TIM-3-PD-1+ stem-like cytotoxic CD8+ T cells: elevated in chronic rhinosinusitis and associated with disease severity

Z Liu, Z Zhao, H Xie, N Lu, J Liu, Q Jiao

Frontiers in Immunology (Frontiers) China, 15 February 2024

Immunology

Key words: chronic rhinosinusitis, PD-1+, CXCR5+, TIM-3-, stem-like CD8+ T cells [more]

INHBA (+) cancer-associated fibroblasts generate an immunosuppressive tumor microenvironment in ovarian cancer

Y Hu, MS Recouvreux, M Haro, E Taylan, BH Taylor-Harding, AE Walts, BY Karlan, S Orsulic

NPJ Precision Oncology (Nature) USA, 15 February 2024

Oncology

Key words: Cell biology, Gynaecological cancer [more]

Quercetin Promotes Apoptosis of Gastric Cancer Cells through the EGFR-ERK Signaling Pathway

, B Zhang, J Zhu, X Wei, R Huang, Y Zhang, Q Jin

Journal of Food Biochemistry (Hindawi) China, 13 February 2024

Oncology

[more]

A Divalent Chikungunya and Zika Nanovaccine with Thermostable Self‐assembly Multivalent Scaffold LS‐SUMO

Q Li, J Zhang, Q Deng, C Liao, J Qian, Z Chen, J Lu

Advanced Healthcare Materials (Wiley) China, 10 February 2024

Virology

[more]

Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner

J Zhao, C Yao, Y Qin, H Zhu, H Guo, B Ji, X Li, N Sun, R Li, Y Wu, K Zheng, Y Pan, T Zhao, J Yang

Cell Death & Disease (Nature) China, 08 February 2024

Oncology

Key words: Cancer immunotherapy, Immunotherapy [more]

Immune checkpoint ligands expressed on mature high endothelial venules predict poor prognosis of NSCLC: have a relationship with CD8+ T lymphocytes infiltration

J Luo, X Shi, Y Liu, J Wang, H Wang, X Yang, Q Sun, Z Hui, F Wie, X Ren, H Zhao

Frontiers in Immunology (Frontiers) China, 08 February 2024

Oncology

Key words: lung cancer, immune checkpoint ligands, high endothelial venules, lymphocytes infiltration, tertiary lymphoid structures [more]

Effect of surface modification on the distribution of magnetic nanorings in hepatocellular carcinoma and immune cells

W Jiao, N Wen, S Wang, G Zhou, Q Lu, Z Su, X Wang, S Hu, Y Xie, N Zhang, X Liu

Journal of Materials Chemistry B (Royal Society of Chemistry) China, 08 February 2024

Oncology, Nanomedicine

Gene therapy corrects the neurological deficits of mice with sialidosis

WL Hwu, K Chang, YH Liu, HC Wang, NC Lee, YH Chien

Gene Therapy (Nature) Taiwan, 07 February 2024

Neuroscience

Key words: Metabolic disorders, Neurological disorders [more]

Assessment of the nano-mechanical properties of healthy and atherosclerotic coronary arteries by atomic force microscopy

F Savvopoulos, MC Keeling, D Carassiti, NA Fogell, MB Patel, J Naser, N Gavara, Rd Silva, R Krams

Journal of the Royal Society Interface (The Royal Society) Uk, Spain, 07 February 2024

Bioimaging

Key words: atomic force microscopy, coronary arteries, atherosclerosis, nano-indentation, collagen microstructure, mechnanical properties [more]

DDAH1 promotes neurogenesis and neural repair in cerebral ischemia

Q Gao, P Ni, Y Wang, P Huo, X Zhang, S Wang, F Xiao, Y Li, W Feng, J Yuan, T Zhang, Q Li, B Fan, Y Kan, Z Li, Y Qi, J Xing, Z Yang, H Cheng, X Gao, X Feng, M Xue, Y Liu, Y Luo, Z Lu, Y Zhao

Acta Pharmaceutica Sinica B (Elsevier) China, 06 February 2024

Neuroscience

Key words: DDAH1, Neurogenesis, Neural repair, ChAT, HIF-1α, Ach, Stroke, ADMA [more]

FSTL1 Accelerates Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration Through TLR4/NF-κB Pathway

X Yan, JY Ding, RJ Zhang, HQ Zhang, L Kang, CY Jia, XY Liu, CL Shen

Inflammation (Springer) China, 06 February 2024

Cell Biology

Key words: FSTL1, Cellular senescence, IVDD, TLR4/NF-κB [more]

Profiling Fibroblast Growth Factor Receptor 3 Expression Based on the Immune Microenvironment in Upper Tract Urothelial Carcinoma

K Shigeta, K Matsumoto, S Kitaoka, M Omura, K Umeda, Y Arita, S Mikami, K Fukumoo, Y Yasimizu, N Tanaka, T Taked, S Morit, T Kosaka, R Mizuno, S Hara, M Oya

European Urology Oncology (Elsevier) Japan, 05 February 2024

Oncology, Urology

Key words: Upper tract urothelial carcinoma, Fibroblast growth factor receptor 3, CD8, CD204, Immune microenvironment [more]

Periostin in Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression by Enhancing Cancer and Stromal Cell Migration

S Miyako, Y Koma, T Nakanishi, S Tsukamoto, K Yamanaka, N Ishihara, Y Azumi, S Urakami, M Shimizu, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki

The American Journal of Pathology (Elsevier) Japan, 05 February 2024

Oncology

[more]

Rapid prototyping of PMMA-based microfluidic spheroid-on-a-chip models using micromilling and vapour-assisted thermal bonding

MAM Ahmed, KM Jurczak, NS Lynn Jr, JPSH Mulder, EMJ Verpoorte, Anika Nagelkerke

Scientific Reports (Nature) The Netherlands, Czech Republic, 03 February 2024

Biological Methods

Key words: Biomedical engineering, Cancer models [more]

Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice

Y Li, C Zhang, Z Li, F Bai, Y Jing, H Ke, S Zhang, Y Yan, Y Yu

Current Issues in Molecular Biolog (MDPI) China, 01 February 2024

Neuroscience

Key words: Spinal cord injury, nicotinamide riboside, NAD+, neuroinflammation, functional recovery [more]

Modified Goldner Trichrome for Non-decalcified Mineralized Tissue Plastinated and Embedded in Resin.

C Panes, N Ponce, NE Ottone, I Valdivia-Gandur, V Beltrán, B Vásquez

International Journal of Morphology (Chilean Society of Anatomy) Chile, 01 February 2024

Biological Methods

Key words: Trichrome staining; Plastic resins; Hard Tissue histology [more]

Urban Particulate Matter Triggers Meibomian Gland Dysfunction

M Tu, R Liu, J Xue, B Xiao, J Li, L Liang

Investigative Ophthalmology & Visual Science (ARVO Journals) China, 01 February 2024

Ophthalmology

[more]

Efficacy and safety of mTOR inhibition in cutaneous sarcoidosis: a single-centre trial

A Redl, K Doberer, L Unterluggauer, L Kleissl, C Krall, C Mayerhofer, B Reininger, V Stary, N Zila, W Weninger, T Weichhart, C Bock, T Krausgruber, G Stary

The Lancet Rheumatology (The Lancet) Austria, 01 February 2024

Pharmacology

[more]

Radiotherapy Resistance of 3D Bioprinted Glioma via ITGA2/P‐AKT Signaling Pathway

D Liu, H Tian, H Li, J Nie, Z Han, G Tang, P Gao, H Cheng, X Dai

Advanced Healtcare Materials (Wiley) China, 30 January 2024

Oncology

Key words: 3D bioprinting, glioma, ITGA2, p-AKT, radiotherapy resistance [more]

Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis

W Chen, B Jin, C Cheng, H Peng, X Zhang, W Tan, R Tang, X Lian, H Diao, N Luo, X Li, J Fan, J Shi, C Yin, J Wang, S Peng, L Yu, J Li, RQ Wu, DM Kuang, GP Shi, Y Zhou, F Wang, X Jiang

Annals of the Rheumatic Diseases (BMJ Journals) China, 30 January 2024

Nephrology

[more]

Neoadjuvant chemotherapy-induced remodeling of human hormonal receptor-positive breast cancer revealed by single-cell RNA sequencing

F Jia, S Sun, J Li, W Wang, H Huang, X Hu, S Pan, W Chen, L Shen, Y Yao, S Zheng, H Chen, W Xia, H Yuan, J Zhou, T Zhang, B Zhang, J Huang

Cancer Letters (Elsevier) China, 30 January 2024

Oncology, Pharmacology

Key words: HR+ breast cancer, Neoadjuvant chemotherapy, Tumor microenvironment, Chemotherapy resistance, Single cell sequencing [more]

Neutralizing IL-16 enhances the efficacy of targeting Aurora-A therapy in colorectal cancer with high lymphocyte infiltration through restoring anti-tumor immunity

SJ Yang, ST Chang, KC Chang, BW Lin, KY Chang, YW Liu, MD Lai, LY Hung

Cell Death & Disease (Nature) Taiwan, 30 January 2024

Oncology, Immunology

Key words: Cancer, Immunology [more]

FLIP (C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress

JD Tischler, H Tsuchida, R Bosire, TT Od, A Park, RO Adeyemi

Nature Communications (Nature) USA, 29 January 2024

Oncology

Key words: Breast Cancer, Homologous recombination, Proteasome, Stalled forks [more]

The Influence of Computed Tomography Contrast Agent on Radiation-Induced Gene Expression and Double-Strand Breaks

S Schüle, F Bunert, C Hackenbroch, M Beer, P Ostheim, S Stewart, M Port, H Scherthan, M Abend

Radiation Research (Radiation Research Society) Germany, 29 January 2024

Radiology, Molecular Biology

New insight into prurigo nodularis: Proadrenomedullin N‐terminal 20 peptide mediates mouse mast cell activation via Mrgprb2

Y Shao, Z Xiao, Y Jin, Y Zhu, Y Shen, T Jin, H Tang, D Wang

Skin Research and Technology (Wiley) China, 29 January 2024

Dermatology, Immunology

Key words: chronic pruritus; mas-related G-protein-coupled receptor X2; mast cells; proadrenomedullin N-terminal 20 peptide; prurigo nodularis [more]

Downregulation of S100A11 promotes T cell infiltration by regulating cancer-associated fibroblasts in prostate cancer

D Han, C Guo, H Cheng, J Lu, Z Hou, X Zhang, Y Luo, B Zhang, W Zhao, P Shang

International Immunopharmacology (Elsevier) China, 28 January 2024

Oncology

Key words: S100A11, CAFs. T cell infiltration, Edafitinib [more]

A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs

C Wang, M Sun, C Shao, L Schlicker, Y Zhuo, Y Harim, T Peng, W Tian, N Stöffler, D Helm, Y Chu, B Fu, X Jin, JP Mallm, M Mall, Y Wu, A Schulze, HK Liu

NPJ Precision Oncology (Nature) China, Germany, 26 January 2024

Oncology, Pharmacology

Key words: Cancer genetics, CNS cancer, Drug screening, Tumour hetereogeneity [more]

Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy

YK Huang, WC Cheng, TT Kuo, JC Yang, YC Wu, HH Wu, CC Lo, CY Hsieh, SC Wong, CH Lu, WL Wu, SJ Liu, YC Li, CC Lin, CN Shen, MC Hung, JT Lin, CC Yeh, YP Sher

Nature Cancer (Nature) Taiwan, 24 January 2024

Oncology

[more]

Salvia miltiorrhiza Bunge extract and Przewalskin ameliorate Bleomycin-induced pulmonary fibrosis by inhibition of apoptosis, oxidative stress and collagen deposition via the TGF-β1 pathway

M Zeng, A Feng, Y Ren, Q Zhang, R Wang, B Zhang, M Liu, P Guo, Y Zhang, J Lyu, X Zheng

Phytomedicine (Elsevier) China, 24 January 2024

Pulmonology

Key words: Przewalskin; Pulmonary fibrosis; SPR ligand fishing; Salvia miltiorrhiza Bunge (Labiatae); Transcriptome sequencing. [more]

Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice

R Driscoll, L Hampton, NA Abraham, JD Larigan, NF Joseph, JCV Hernandez-Vega, S Geisler, FC Yang, M Deninger, DT Tran, N Khatri, BMDC Godinho, GA Kinberger, DR Montagna, WD Hirst, CL Guardado, KE Glajch, HM Arnold, CLB Gallant-Behm, A Weihofen

Scientific Reports (Nature) USA, 24 January 2024

Neuroscience

Key words: Huntington's disease, Pharmacodynamics [more]

Gut ribotoxic stress responses facilitate dyslipidemia via metabolic reprogramming: an environmental health prediction

J Kim, H Jeong, N Ray, KH Kim, Y Moon

Theranostics (Ivyspring) South Korea, 20 January 2024

Gastroenterology

Key words: Ribotoxic stress responses, human inflammatory bowel diseases, dyslipidemia, LDL receptor, deoxynivalenol [more]

Impairment of adenosine signaling disrupts early embryo development: unveiling the underlying mechanisms

T Glaser, P Martins, R Beco, CA Bento, AR Cappellari, SLB Oliveira, CA Merkel, VFS Arnaud-Sampaio, C Lameu, AM Battastini, H Ulrich

Frontiers in Pharmacology (Frontiers) Brazil, 19 January 2024

Pharmacology

Key words: purinergic signaling, ERK1/2, calcium signaling, embryonic stem cells, adenosine, caffeine [more]

IL-6 upregulates expression of LMO4 in psoriatic keratinocytes through activation of the MEK/ERK/NF-κB pathway

Z Tu, W Wei, F Zeng, W Wang, Y Zhang, Y Zhang, F Zhou, C Cai, S Zhang, H Zhou

The American Journal of Pathology (Elsevier) China, 19 January 2024

Dermatology

[more]

Differential pathogenic and molecular features in neurological infection of SARS‐CoV‐2 Omicron BA. 5.2 and BA. 2.75 and Delta

E Wang, QJ Yang, XX Xu, QC Zou, Y Long, G Ma, ZH Deng, JB Zhao, MH Li, J Zeng

Journal of Medical Virology (Wiley) China, 18 January 2024

Virology

Key words: BA.2.75, BA.5.2, Delta, hACE2 knock‐in mice, neurological dysfunction, SARS‐CoV‐2, Spike protein, γ‐secretase [more]

Strain-induced bands of Büngner formation promotes axon growth in 3D tissue-engineered constructs

C Hromada, D Szwarc-Hofbauer, MQ Nguyen, J Tomasch, M Purtscher, D Hercher, AH Teuschl-Woller

Journal of Tissue Engineering (Sage Journals) Austria, 18 January 2024

Neuroscience

[more]

Microbial colony sequencing combined with metabolomics revealed the effects of chronic hexavalent chromium and nickel combined exposure on intestinal inflammation in mice

Y Gu, S Zheng, C Huang, X Cao, P Liu, Y Zhuang, G Li, G Hu, X Gao, X Guo

Science of The Total Environment (Elsevier) China, 18 January 2024

Gastroenterology

Key words: Hexavalent chromium,Nickel, Inflammatory response, Microbiome, Metabolomics [more]

Analysis of organoid and immune cell co-cultures by machine learning-empowered image cytometry

P Stüve, B Nerb, S Harrer, M Wuttke, M Feuerer, H Junger, E Eggenhofer, B Lungu, S Laslau, U Ritter P Stüve, B Nerb, S Harrer, M Wuttke, M Feuerer, H Junger, E Eggenhofer, B Lungu, S Laslau, U Ritter

Frontiers in Medicine (Frontiers Media S.A.) Germany, Romania, 17 January 2024

Medical Image Analysis, Machine Learning

[more]

Salvia miltiorrhiza Bunge extract and Przewalskin ameliorate Bleomycin-induced pulmonary fibrosis by inhibition of apoptosis, oxidative stress and collagen …

M Zeng, A Feng, Y Ren, Q Zhang, R Wang, B Zhang, M Liu, P Guo, Y Zhang, J Lyu, X Zheng

Phytomedicine (Elsevier) China, 17 January 2024

Pharmacology, Pulmonology

Key words: Salvia miltiorrhiza Bunge (Labiatae), Przewalskin, Pulmonary fibrosis, Transcriptome sequencing, SPR ligand fishing [more]

Spatial and Single-Cell Transcriptomics Reveal a Cancer-Associated Fibroblast Subset in HNSCC That Restricts Infiltration and Antitumor Activity of CD8+ T Cells

C Li, H Guo, P Zhai, M Yan, C Liu, X Wang, C Shi, J Li, T Tong, Z Zhang, H Ma, J Zhang

Cancer Research (AACR) China, 16 January 2024

Oncology

Key words: Lymphocyte biology [more]

Myeloid zfhx3 deficiency protects against hypercapnia-induced suppression of host defense against influenza A virus

SM CasalinoMatsuda, F Chen, F GonzalezGonzalez, H Matsuda, A Nair, H AbdalaValencia, G Budinger, JT Dong, G Beitel, P Sporn

JCI insight (American Society for Clinical Investigation) USA, China, 16 January 2024

Immunology, Virology

Key words: Influenza, Innate immunity, Macrophages [more]

The effector program of human CD8 T cells supports tissue remodeling

M Delacher, L Schmidleithner, M Simon, P Stüve, L Sanderink, A Hotz-Wagenblatt, M Wuttke, K Schambeck, B Ruhland, V Hofmann, S Bittner, U Ritter, A Pant, SS Helbich, M Voss, NA Lemmermann, L Bessiri-Schake, T Bohn, A Eigenberger, AN Menevse, C Gebhard, N Strieder, H Abken, M Rehli, J Huehn, P Beckhove, T Hehlgans, H Junger, EK Geissler, L Prantl, JM Werner, C Schmidl, B Brors, CD Imbusch, M Feuerer

Journal of Experimental Medicine (Rockerfeller University Press) Germany, 16 January 2024

Oncology, Pharmacology

[more]

Spatial and Single-Cell Transcriptomics Reveal a Cancer-Associated Fibroblast Subset in HNSCC That Restricts Infiltration and Antitumor Activity of CD8+ T Cells

C Li, H Guo, P Zhai, M Yan, C Liu, X Wang, C Shi, J Li, T Tong, Z Zhang, H Ma, J Zhang

Cancer Research (AACR) China, 16 January 2024

Oncology

Key words: Lymphocyte biology [more]

FMRP regulation of aggrecan mRNA translation controls perineuronal net development

HM Van't Spijker, JD Richter

Journal of Neurochemistry (Wiley) USA, UK, 15 January 2024

Neuroscience

Key words: aggrecan, FMRP, fragile X syndrome, perineuronal net [more]

SHCBP1 Overexpression Aggravates Pancreatitis by Triggering the Loss of Primary Cilia

L Li, H Zhao, Z Li, W Shi, Z Jiao

DNA and Cell Biology (Mary Ann) China, 12 January 2024

Cell Biology

Key words: LPS; SHCBP1; acute pancreatitis; cerulein; primary cilia. [more]

Circadian misalignment impairs oligodendrocyte myelination via Bmal1 overexpression leading to anxiety and depression‐like behaviors

Y Zuo, Y Hou, Y Wang, L Yuan, L Cheng, T Zhang

Journal of Pineal Research (Wiley) China, 12 January 2024

Neuroscience

Key words: Bmal1, circadian misalignment, mood, myelin, oligodendrocyte [more]

BNIP3 in hypoxia-induced mitophagy: Novel insights and promising target for non-alcoholic fatty liver disease

M Tian, J Hou, Z Liu, Z Li, D Huang, Y Zhang, Y Ma

The International Journal of Biochemistry & Cell Biology (Elsevier) China, 11 January 2024

Hepathology

Key words: BNIP3; Hypoxia; Mitophagy; NAFLD; β-oxidation. [more]

Unraveling the Role of miR-200b-3p in Attention-Deficit/Hyperactivity Disorder (ADHD) and Its Therapeutic Potential in Spontaneously Hypertensive Rats (SHR)

TM Chang, HL Lin, CC Tzang, JA Liang, TC Hsu, BS Tzang

Biomedicines (MDPI) Taiwan, 10 January 2024

Neuroscience

Key words: taurine, attention deficit hyperactivity disorder (ADHD), neuropsychiatric disorder, microRNA (miR)-200b-3p, striatum; spontaneously hypertensive rats (SHR), inflammatory factors, spontaneous alternations [more]

Effects of Citrus depressa Hayata juice on high-fat diet-induced obesity in HBV transgenic mice

PY Chu, CL Hsu, YA Lin, YC Pan, YH Dai, YC Yu, JC Yang, WL Ma, YJL Chen, CL Lee, YC Wu

Heliyon (Cell Press) Taiwan, 10 January 2024

Nutritional science

Key words: Citrus depressa hayata, Juice, fermentation, Polyphenol, Hesperidin, High-fat diet-induced obesity, HBV, Mice [more]

Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice

X Bai, B Wang, Y Cui, S Tian, Y Zhang, L You, YZ Chang, G Gao

Journal of Neuroinflammation (Springer) China, 09 January 2024

Neuroscience

Key words: Hepcidin, Iron, Alzheimer's disease, Hippocampal neurogenesis, Cognitive dysfunction [more]

Amyloid Burden Correlates with Electrocardiographic Findings in Patients with Cardiac Amyloidosis—Insights from Histology and Cardiac Magnetic Resonance Imaging

F Duca, R Rettl, C Kronberger, M Poledniczek, C Binder, D Dalos, M Koschutnik, C Donà, D Beitzke, C Loewe, C Nitsche, C Hengstenberg, R Badr-Eslam, J Kastner, J Bergler-Klein, AA Kammerlander

Journal of Clinical Medicine (MDPI) Austria, 09 January 2024

Cardiology

Key words: cardiac amyloidosis; transthyretin amyloidosis; light chain amyloidosis; electrocardiogram; histology; T1 mapping; extracellular volume; cardiac magnetic resonance imaging [more]

PD-L1-positive circulating endothelial progenitor cells associated with immune response to PD-1 blockade in patients with head and neck squamous cell carcinoma

NW Su, SH Dai, K Hsu, KM Chang, CC Ko, CW Kao, YF Chang, CG Chen

Cancer Immunology, Immunotherapy (Springer) Taiwan, 04 January 2024

Immunology, Oncology

Key words: PD-1, PD-L1, Head and neck cancer, Circulating endothelial cell, Circulating endothelial progenitor cell [more]

Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion

R Yan, P Zhang, S Shen, Y Zeng, T Wang, Z Chen, W Ma, J Feng, C Suo, T Zhang, H Wei, Z Jiang, R Chen, S Li, X Zhong, W Jia, L Sun, C Cang, H Zhang, P Gao

Nature Immunology (Nature) China, 04 January 2024

Oncology

[more]

Knockout of Shcbp1 sensitizes immunotherapy by regulating α‐SMA positive cancer‐associated fibroblasts

Q Gu, Z Ma, Q Wang, Y Dai, W Shi, Z Jiao

Molecular Carcinogenesis (Wiley) China, 03 January 2024

Oncology, Immunology

Key words: breast cancer, CAFs, Erdafitinib, ICT, Shcbp1 [more]

OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB

W Ma, Y Sun, R Yan, P Zhang, S Shen, H Lu, Z Zhou, Z Jiang, L Ye, Q Mao, N Xiong, W Jia, L Sun, P Gao, H Zhan

Molecular Cell (Cell Press) China, 03 January 2024

Oncology

[more]

Applications of Digital Pathology in Cancer: A Comprehensive Review

M Omar, MK Alexanderani, I Valencia, M Loda, L Marchionni

Annual Review of Cancer Biology (Annual Reviews) USA, UK, 02 January 2024

Oncology

Key words: digital pathology, whole-slide imaging, deep learning, artificial intelligence, cancer research, histopathology image analysis

Function and mechanism of GBP1 in the development and progression of cervical cancer

S Wang, Y Zhang, X Ma, Y Feng

Journal of Translational Medicine (BMC) China, 02 January 2024

Oncology

Key words: Guanylate binding protein 1 (GBP1), Tumor immunity, Cervical cancer, Alternative splicing (AS), Cancer promotion [more]

Effects of poly (ADP-ribose) polymerase inhibitor treatment on the repair process of ischemic acute kidney injury

J Jeon, K Lee, HR Jang, KE Yang, CJ Lee, H Ahn, WY Park, JE Lee, GY Kwon, YG Kim, W Huh

Scientific Reports (Nature) South Korea, 02 January 2024

Nephrology

Key words: Acute kidney injury, Inflammation [more]

USP29 alleviates the progression of MASLD by stabilizing ACSL5 through K48 deubiquitination

S Hu, Z Wang, K Zhu, H Shi, F Qin, T Zhang, S Tian, Y Ji, J Zhang, J Qin, Z She, X Zhang, P Zhang, H Li

Clinical and Molecular Hepatology (Korean Association for the Study of the Liver) China, 02 January 2024

Hepathology, Molecular Biology

Key words: USP29, MASLD, ACSL5, Fatty acid β-oxidation, Deubiquitination [more]

Digitale Pathologie in Österreich

C Schatz, A Qerimi, J Haybaeck

Die Pathologie (Springer) Austria, 01 January 2024

Medical Image Analysis

Key words: Metadata whole slide images, Telepatholgy, AI, Diagnosis, whole slide images

Proteomics Analysis to Explore the Resistance Genes of Silkworm to Bombyx mori Nuclear Polyhedrosis Virus

G Ouyang, H Qian, J Sun, R Yang, T Gui, W Wang, Q Liu, A Chen

Genes (MDPI) China, 30 December 2023

Virology

Key words: B. mori, BmNPV, resistance gene, 2-DE, qRT-PCR [more]

Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury

CJ Yang, HC Chang, PC Sung, MC Ge, HY Tang, ML Cheng, HT Cheng, HH Chou, CY Lin, WR Lin, YS Lee, SY Hsieh

Cell Reports (Cell Press) Taiwan, 27 December 2023

Hepathology

[more]

In vivo imaging reveals a synchronized correlation among neurotransmitter dynamics during propofol and sevoflurane anesthesia.

GL Qiu, LJ Peng, P Wang, ZL Yang, JQ Zhang, H Liu, XN Zhu, J Rao, XS Liu

Zoological Research (search.ebscohost.com) China, 26 December 2023

Neuroscience

Key words: General anesthesia, Loss of consciousness, In vivo neurotransmitter imaging, Medial prefrontal cortex, Primary visual cortex

Electron irradiation of zein protein-loaded nano CaO2/CD for enhancing infectious diabetic wounds with adaptive hydrophobicity-to-hydrophilicity

L Zhou, S Guo, Z Dong, P Liu, W Shi, L Shen, J Yin

Materials Today Advances (Elsevier) China, 23 December 2023

Pharmacology

Key words: Diabetic wound healing, Antibacterial property, Reactive oxygen species, Inflammation suppression, Macrophage polarization, Adaptive hydrophobicity-to-hydrophilicity [more]

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

J Chen, Q Zheng, JL Hicks, L Trabzonlu, B Ozbek, , T Jones, AM Vaghasia, TC Larman, R Wang, MC Markowski, SR Denmeade, KJ Pienta, RH Hruban, ES Antonarakis, A Gupta, CV Dang, S Yegnasubramanian, AM De Marzo

JCI insight (The american society for clinical investigation) USA, 22 December 2023

Oncology

Key words: Metabolism, Oncology, Cancer, Mitochondria [more]

Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ

X Cai, R Wang, J Zhu, X Li, X Liu, G Ouyang, J Wang, Z Li, C Zhu, H Deng, W Xiao

Cell Reports (Cell Press) China, 20 December 2023

Immunology

Key words: Immunology, FIH, IKKϵ, MAVS, TBK1, TRAF3, hydroxylation, hypoxia, innate immunity, mouse, zebrafish [more]

Relationship between Aspartame-Induced Cerebral Cortex Injury and Oxidative Stress, Inflammation, Mitochondrial Dysfunction, and Apoptosis in Sprague Dawley Rats

J U-pathi, YC Yeh, CW Chen, EE Owaga, RH Hsieh

Antioxidants (MDPI) Taiwan, Kenya, 19 December 2023

Nutritional science

Key words: aspartame, inflammation, oxidative stress, mitochondrial biogenesis, apoptosis [more]

Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits

WL Septiana, W Ayudyasari, H Gunardi, JA Pawitan, GM Balachander, H Yu, RD Antarianto

In Vitro Cellular & Developmental Biology - Animal (Springer) Indonesia, Singapore, India, 18 December 2023

Hepathology

Key words: Liver organoid, iPSCs, Hepatocyte-differentiation, Transplant, Liver failure [more]

Renoprotective effects of extracellular fibroblast specific protein 1 via nuclear factor erythroid 2-related factor-mediated antioxidant activity

N Takahashi, S Yokoi, H Kimura, H Naiki, T Matsusaka, Y Yamamoto, K Nakatani, K Kasuno, M Iwano

Scientific Reports (Nature) Japan, 18 December 2023

Nephrology

Key words: Medical research, Nephrology [more]

Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling

Y Wang, M Yao, C Li, K Yang, X Qin, L Xu, S Shi, C Yu, X Meng, C Xie

Experimental Hematology & Oncology (BMC) China, 16 December 2023

Oncology

Key words: KRASG12C, c-Myc, PLK1, LncRNA, ST8SIA6-AS1, Drug resistance [more]

Melatonin exhibits partial protective effects against gemcitabine-and cisplatin-induced kidney and reproductive injuries in mice

SC Wang, HC Hsu, YC Chang, CY Yu, CT Liu, WW Sung

Aging (Impact Journals) Taiwan, 14 December 2023

Nephrology, Reproductive Medicine

Key words: melatonin, hormone, testosterone, sperm, chemotherapy [more]

In silico analyses of pan-squamous cell carcinoma unveiled the immunological implications of MRPL13, which had previously been under-recognized

Y Liang, S He, Y Tan, Q Liu, F Zhao, T Liu, C Huang, X Lu, S Zheng

Heliyon (Cell) China, 14 December 2023

Oncology, Immunology

Key words: MRPL13, Pan-squamous cell carcinoma, Bioinformatics analysis, Prognostic, CD8+ T-cell infiltration [more]

Egocentric processing of items in spines, dendrites, and somas in the retrosplenial cortex

N Cheng, Q Dong, Z Zhang, L Wang, X Chen, C Wang

Neuron (Cell Press) China, 14 December 2023

Neuroscience

Key words: retrosplenial, egocentric, dendrite, spine, goal, context, landmark [more]

Static Magnetic Field Reduces Intracellular ROS Levels and Protects Cells Against Peroxide-Induced Damage: Suggested Roles for Catalase

ECG Frachini, JB Silva, B Fornaciari, MS Baptista, H Ulrich, DFS Petri

Neurotoxicity Research (Springer) Brazil, 14 December 2023

Neuroscience

Key words: External magnetic field, Oxidative stress, Neuroprotection, SH-SY5Y cells, Cell proliferation [more]

ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-Guided Analysis

VA Arrieta, J Duerinck, KB Burdett, KJ Habashy, W Geens, A Gould, JK Schwarze, C Dmello, KS Kim, R Saganty, L Chen, A Moscona, M McCord, C Lee-Chang, CM Horbinski, H Zhang, R Stupp, B Neyns, AM Sonabend

Clinical Cancer Research (AACR) Belgium, USA, Mexico, 13 December 2023

Oncology, Pharmacology

[more]

Chlamydia suis survival in dust: First insights–A short communication

C Unterweger, M Koch, S Winkler, S Hammer, A Oppeneder, A Ladinig

Research in Veterinary Science (Elsevier) Austria, 13 December 2023

Microbiology

Key words: Chlamydia suis, Pigs, Dust, Transmission, Disinfection, Viability [more]

The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development

MF Chen, CC Hu, YH Hsu, YC Lin, KL Chen, SWN Ueng, Y Chang

Bone & Joint Research (The British Editorial Society of Bone & Joint Surgery) Taiwan, 12 December 2023

Osteology

Key words: Osteoarthritis, EDIL3, Chondrocyte, Extracellular matrix, Cartilage, osteoarthritic changes, cartilage tissues, extracellular matrix, chondrocytes, antibodies, interleukin, aggrecan, pro-inflammatory cytokines, OARSI, subchondral bone plate [more]

Differential effects of microRNAs miR‐21, miR‐99 and miR‐145 on lung regeneration and inflammation during recovery from influenza pneumonia

JWJ Ong, KS Tan, JJX Lee, JE Seet, HW Choi, SG Ler, J Gunaratne, T Narasaraju, L-T Sham, V Patzel, VT Chow

Journal of Medical Virology (Wiley Online Library) Singapore, India, UK, 12 December 2023

Pulmonology

Key words: influenza, lung regeneration, microRNAs, miR-21, mi-99a, miR-145, pneumonia, proliferating AT2 cells, RNA sequencing, stem cells [more]

Corynoline inhibits esophageal squamous cell carcinoma growth via targeting Pim-3

Y Shi, Q Yuan, Y Chen, X Li, Y Zhou, H Zhou, F Peng, Y Jiang, Y Qiao, J Zhao, C Zhang, J Wang, K Liu, Z Dong

Phytomedicine (Elsevier) China, 12 December 2023

Oncology, Pharmacology

Key words: Proviral integration site for maloney murine leukemia virus 3, corynoline, esophageal squamous cell carcinoma, proliferation, apoptosis [more]

Granzyme K–and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease

R Koga, T Maehara, R Aoyagi, R Munemura, Y Murakami, A Doi, M Kono, H Yamamoto, H Niiro, T Kiyoshima, M Tanabe, T Nakano, Y Matsukuma, M Kawano, JH Stone, S Pillai, S Nakamura, S Kawano

Journal of Allergy and Clinical Immunology (Elsevier) Japan, USA, 11 December 2023

Immunology

Key words: Single-cell RNA sequencing, IgG4-related disease, granzyme K, cytotoxic T cells, fibrosis, amphiregulin, double-negative (DN) B [more]

Hypoxia is correlated with the tumor immune microenvironment: Potential application of immunotherapy in bladder cancer

H Chen, Y Zhang, X Chen, R Xu, Y Zhu, D He, Y Cheng, Z Wang, X Qing, K Cao

Cancer Medicine (Wiley Online Library) China, 08 December 2023

Oncology, Pharmacology

Key words: bladder cancer, hypoxia, immune checkpoint inhibitorn TLR8, tumor microenviorment [more]

A breast cancer classification and immune landscape analysis based on cancer stem-cell-related risk panel

H Hu, M Zou, H Hu, Z Hu, L Jiang, D Escobar, H Zhu, W Zhan, T Yan, T Zhang

NPJ Precision Oncology (Nature) China, USA, 08 December 2023

Oncology

Key words: Cancer genomics, Prognostic markers [more]

Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis

YY Wang, KH Cheng, AC Hung, S Lo, PY Chen, YC Wu, MF Hou, SSF Yuan

International Journal of Oncology (Spandios Publications) Taiwan, 07 December 2023

Oncology, Molecular Biology

[more]

Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer

W Tang, G Li, Q Lin, Z Zhu, Z Wang, Z Wang

Journal of Translational Medicine (Springer) China, 07 December 2023

Oncology

Key words: Gastric cancer, Cholersterol metabolism, Metabolic subtypes, Immunotheerapy, Prognostic signature, Biomarkers [more]

Pro‐inflammatory cytokine IL‐6 regulates LMO4 expression in psoriatic keratinocytes via AKT/STAT3 pathway

Z Tu, W Wei, Q Xiang, W Wang, S Zhang, H Zhou

Immunity, Inflammation and Disease (Wiley Online Library) China, 06 December 2023

Dermatology, Molecular Biology

Key words: AKT, interleukin‐6, LMO4, psoriasis, STAT3 [more]

ALDOB/KAT2A interactions epigenetically modulate TGF-β expression and T cell functions in hepatocellular carcinogenesis

C Yin, C Zhang, Y Wang, G Liu, N Wang, N Liang, L Zhang, Q Tu, J Lv, H Jiang, H Ma, C Du, M Li, X He, S Chen, J Guo, S Li, J Qin, N Li, Y Tao, H Yin

Hepatology (AASLD) China, 05 December 2023

Hepathology, Oncology

[more]

Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma

J Duan, Y Zhang, R Chen, L Liang, Y Huo, S Lu, J Zhao, C Hu, Y Sun, K Yang, M Chen, Y Yu, J Ying, R Huang, X Ma, S Leaw, F Bai, Z Shen, S Cai, D Gao, J Wang, Z Wang

Cell Reports Medicine (Cell Press) China, 04 December 2023

Oncology, Pharmacology

Key words: squamous NSCLC, PD-1 blockade, biomarkers PD-L1, tumor mutational burden, gene expression signature, NRF2, tislelizumab clinical trial, immunotherapy [more]

SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats

A Shankar, CK Deal, S McCahon, K Callegari, T Seitz, L Yan, DM Drown, CT Williams

Chronobiology International (Taylor & Francis) USA, 04 December 2023

Nutritional science, Gastroenterology

Key words: Photoperiod, seasonal affective disorder, metabolic dysbiosis, non-alcoholic fatty liver disease [more]

Excessive Lipid Peroxidation in Uterine Epithelium Causes Implantation Failure and Pregnancy Loss

Y Lu, Y Shao, W Cui, Z Jia, Q Zhang, Q Zhao, ZJ Chen, J Yan, B Chu, J Yuan

Advanced Science (Wiley) China, 03 December 2023

Reproductive Medicine

[more]

A prognostic model based on Scissor+ cancer associated fibroblasts identified from bulk and single cell RNA sequencing data in head and neck squamous cell carcinoma

G Tian, J Zhang, Y Bao, Q Li, J Hou

Cellular Signalling (Elsevier) China, 03 December 2023

Oncology

Key words: HNSCC, Fibroblasts, Scissor, scRNA-seq [more]

Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway

XC Wang, XL Li, XN Ma, LD Zhang, TY Han, DK Zhang

Naunyn-Schmiedeberg's Archives of Pharmacology (Springer) China, 02 December 2023

Gastroenterology, Pharmacology

Key words: Autophagy, Dihydromyricetin, Inflammatory bowel disease, Intestinal fibrosis [more]

Downregulation of N4-acetylcytidine modification in myeloid cells attenuates immunotherapy and exacerbates hepatocellular carcinoma progression

N Xu, J Zhuo, Y Chen, R Su, H Chen, Z Zhang, Z Lian, D Lu, X Wei, S Zheng, X Xu, S Wang, Q Wei

British Journal of Cancer (Nature) China, 01 December 2023

Oncology, Pharmacology

Key words: Cancer immunotherapy, Translational research [more]

Spatiotemporal characterization of glial cell activation in an Alzheimer's disease model by spatially resolved transcriptomics

H Choi, EJ Lee, JS Shin, H Kim, S Bae, Y Choi, DS Lee

Experimental & Molecular Medicine (Nature) South Korea, 01 December 2023

Neuroscience

Key words: Alzheimer's disease, Transcriptomics, Translational research [more]

Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury

K Štepánková, M Chudíčková, Z Šimková, N Martinez-Varea, S Kubinová, L Machová Urdzíková, P Jendelová, JF Kwok

Scientific Reports (Nature) Czech Republic, UK, 29 November 2023

Neuroscience, Pharmacology

Key words: Molecular neuroscience, Regeneration and repair in the nervous system, Synaptic plasticity [more]

Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development

T Vanova, J Sedmik, J Raska, KA Cerna, P Taus, V Pospisilova, M Nezvedova, V Fedorova, S Kadakova, H Klimova, M Capandova, P Orviska, P Fojtik, S Bartova, K Plevova, Z Spacil, H Hribkova, D Bohaciakova

Cell Reports (Cell) Czech Republic, 28 November 2023

Neuroscience

[more]

Low-intensity exercise training increases systolic function of heart and MHCII low cardiac resident macrophages

G Wang, L Wang, X Wang, H Ye, W Ni, W Shao, C Dai, B Liu

Heliyon (Cell Press) China, 28 November 2023

Cardiology

Key words: Cardiac macrophage, Ejection fraction, Heart, Low-intensity exerciseInnate immunity [more]

FiCRoN, a deep learning-based algorithm for the automatic determination of intracellular parasite burden from fluorescence microscopy images

G Juez-Castillo, B Valencia-Vidal, LM Orrego, M Cabello-Donayre, L Montosa-Hidalgo, JM Pérez-Victoria

Medical Image Analysis (Elsevier) Spain, Colombia, 28 November 2023

Key words: Deep learning, Fluorescence imaging, Heme, Intracellular parasites, Leishmania

Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

A Eigentler, F Handle, S Schanung, A Degen, H Hackl, HHH. Erb, G Fotakis, J Hoefer, C Ploner, K Jöhrer, I Heidegger, A Pircher, W Klotz, M Herold, G Schäfer, Z Culig, M Puhr

Oncogene (Nature) Austria, Germany, 28 November 2023

Oncology, Pharmacology

Key words: Extracellular matrix, Extracellular signalling molecules, Hormone receptors, Prostate cancer [more]

Analysis of cells of epithelial, connective tissue and immune differentiation in HPV-positive-, HPV-negative oropharyngeal carcinoma and normal oropharyngeal tissue by immunofluorescence multiplex image cytometry: a preliminary report

AI Giotakis, A Runge, J Dudas, R Glueckert, T Gottfried, VH Schartinger, J Klarer, A Randhawa, E Caimmi, H Riechelmann

BMC cancer (Springer) Austria, USA, 27 November 2023

Oncology, Cell Biology

Key words: Image cytometry, Fluorescent antibody technique, Epithelial cells, Connective tissue, Leukocytes, Oropharyngeal neoplasms, Human papilloma virus [more]

Diverse macrophage populations contribute to distinct manifestations of human cutaneous graft-versus-host disease

J Strobl, LM Gail, L Krecu, S Madad, Lisa Kleissl, L Unterluggauer, A Redl, K Brazdilova, S Saluzzo, P Wohlfarth, HA Knaus, M Mitterbauer, W Rabitsch, M Haniffa, G Stary

British Journal of Dermatology (Oxford Academic) Austria, UK, 27 November 2023

Immunology, Dermatology

[more]

Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway

MQ Yan, BH Zhu, XH Liu, YM Yang, XY Duan, Y Wang, H Sun, M Feng, T Li, XM Liu

Cell Death & Disease (Nature) China, 27 November 2023

Reproductive Medicine

Key words: Cell proliferation, HIPPO signalling, Infertility, Mitochondria [more]

Double‐Orthogonal Gradient‐Based High‐Throughput Screening Platform for Studying Cell Response Toward Combined Physicochemical Biomaterial Properties

TAB van der Boon, LE Tromp, L Ge, L Yang, CF Guimaraes, PT Kühn, Q Zhou, RA Bank, TG van Kooten, P van Rijn

Small Science (Wiley) The Netherlands, China, 27 November 2023

Tissue Engineering

Key words: biointerfaces, combinatorial gradients, high-throughput screenings, materiobiology, stem cells [more]

Acute expression of human APOBEC3B in mice results in RNA editing and lethality

A Alonso de la Vega, NA Temiz, R Tasakis, K Somogyi, L Salgueiro, E Zimmer, M Ramos, A Diaz-Jimenez, S Chocarro, M Fernández-Vaquero, B Stefanovska, E Reuveni, U Ben-David, A Stenzinger, T Poth, M Heikenwälder, N Papavasiliou, RS Harris, R Sotillo

Genome Biology (Springer) Germany, USA, Israel, 24 November 2023

Genetics

Key words: APOBEC3B, RNA editing, Mutations, Mouse models, DNA damage [more]

Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8+ exhausted-like T cells

S Li, K Li, K Wang, H Yu, X Wang, M Shi, Z Liang, Z Yang, Y Hu, Y Li, H Li, S Cheng, L Ye, Y Yang

Nature Communications (Nature) China, 24 November 2023

Oncology, Radiotherapy

Key words: Cancer therapy, Hepatocellular carcinoma, Radiotherapy, Tumour immunology [more]

Brief Review of the Origins of Plastination

NE Ottone

Advances in Plastination Techniques (Springer) , 23 November 2023

Epoxy Sheet Plastination Technique

NE Ottone

Advances in Plastination Techniques (Springer) , 23 November 2023

Improved cardioprotective effect of 3‐nitro‐N‐methyl salicylamide solution after a prolonged preservation time of rat heart

S Wang, W Liu, S Liu, J Li, Y Geng, Y Zhao

Clinical and Experimental Pharmacology and Physiology (Wiley) China, 23 November 2023

Cardiology

[more]

Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and in vitro experiments

H Chen, J Sameshima, S Yokomizo, T Sueyoshi, H Nagano, Y Miyahara, T Sakamoto, S Fujii, T Kiyoshima, T Guy, S Nakamura, M Moriyama, N Kaneko, S Kawano

Frontiers in Immunology (Frontiers Media S.A.) Japan, UK, 23 November 2023

Immunology, Oncology

Key words: oral squamous cell carcinoma, CD4+ cytotoxic T lymphocytes, CTLA-4, T cell dysfunction, CXCL13, double negative B cells [more]

Qi Fu Yin ameliorates neuroinflammation through inhibiting RAGE and TLR4/NF-κB pathway in AD model rats

C He, W Yu, M Yang, Z Li, J Yu, D Zhong, S Deng, Z Song, S Cheng

Aging (Impact Journals) China, 22 November 2023

Neuroscience, Pharmacology

Key words: Alzheimer’s disease, traditional Chinese medicine, neuroinflammation, RAGE, TLR4/NF-κB signaling pathway [more]

Identification of tryptophan metabolism-related genes in immunity and immunotherapy in Alzheimer's disease

Z Song, ZX Wu, RS Luo, C He, Z Li, M Yang, W Yu, JW He, S Deng, S Cheng

Aging (Impact Journals) China, 20 November 2023

Immunology, Neuroscience

Key words: Alzheimer’s disease, tryptophan metabolism-related genes, DEGs, WGCNA, bioinformatics [more]

Pharmacological effects and mechanism of Maxing Shigan decoction in the treatment of Pseudomonas aeruginosa pneumonia

Y Xu, L Bao, S Cao, B Pang, J Zhang, Y Zhang, M Chen, Y Wang, Q Sun, R Zhao, S Guo, J Sun, X Cui

Journal of Ethnopharmacology (Elsevier) China, 19 November 2023

Pharmacology

[more]

Impact of Perinatal Co-exposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs (preprint)

M Lahimer, N Djekkoun, SZ Tricotteaux-Zarqaoui, A Corona, I Lafosse, HB Ali, M Ajina, V Bach, M Benkhalifa, HC Khorsi-Cauet

Toxics (MDPI) France, Tunisia, 19 November 2023

Nutritional science, Reproductive Medicine

Key words: chlorpyrifos; high-fat diet; Kisspeptin; GnRHR; ovary; testis; rat [more]

Vasari-Based Features Nomogram to Predict the Tumor-Infiltrating CD8+ T Cell Levels in Glioblastoma

C Xue, Q Zhou, B Zhang, X Ke, P Zhang, X Liu, S Li, J Deng, J Zhou

Academic Radiology (Elsevier) China, 18 November 2023

Radiotherapy, Oncology

Key words: CD8 + T cells; Glioblastoma; Magnetic resonance imaging; Visually AcceSAble Rembrandt Images. [more]

Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model

Z Zhang, N Zhang, X Lu, M Zhou, X Yan, W Gu, J Yang, Q Zhang, C Zhang, Y Gong, M Jia, X Zhang, P Ning, M Liu, X Li, X Shi, W Liu, GF Gao, G Ning, J Wang, Y Bi

Zoological Research (Oxford Academic) China, 18 November 2023

Virology

Key words: SARS-CoV-2, Diabetes, Mouse model, Heparin, Antiviral therapy [more]

Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer

S Kandala, M Ramos, LV von Voithenberg, A Diaz-Jimenez, S Chocarro, J Keding, B Brors, CD Imbusch, R Sotillo

Cell Reports (Cell Press) Germany, 17 November 2023

Oncology

Key words: CP: Cancer; CP: Cell biology; Her2(+) breast cancer; NF-κβ signaling; chromosomal instability; immune evasion; senescence-associated secretory phenotype, SASP; single-cell sequencing. [more]

Exploring CD39 and CD73 Expression as Potential Biomarkers in Prostate Cancer

CFF Gardani, EL Pedrazza, VS Paz, GG Zanirati, J Costa da Costa, R Andrejew, H Ulrich, JN Scholl, F Figueiró, L Rockenbach, F Bueno Morrone

Pharmaceuticals (MDPI) Brazil, 16 November 2023

Oncology

Key words: prostate cancer; ectonucleotidases; CD39; CD73; extracellular vesicles [more]

Structural, electrochemical, biological, and mechanical assessment of functionally graded Cr-based multilayers for enhanced metal-ceramic bond strength in dental restorations

M Dinu, CM Cotrut, T Petreus, T Hauffman, F Baciu, A Vladescu

Materials Chemistry and Physics (Elsevier) Romania, UK, Belgium, Russia, 15 November 2023

Biomaterials

Key words: Oxynitride, Cathodic arc, EIS, Cytotoxicity, Bond strength [more]

Impact of the-1T> C single-nucleotide polymorphism of the CD40 gene on the development of endothelial dysfunction in a pro-diabetic microenvironment

P Joshi, F Mohr, C Rumig, E Kliemank, G Krenning, S Kopf, M Hecker, AH Wagner

Atherosclerosis (Elsevier) Germany, The Netherlands, 14 November 2023

Endocrinology

Key words: Single nucleotide polymorphism, CD40, Endothelial cells, Endothelial-to-mesenchymal transition [more]

Transcriptional regulation of macrophage inflammation in the heart failure with preserved ejection fraction: a translational study

E Gorica, SA Mohammed, A Mengozzi, S Ambrosini, FA Wenzl, A Mongelli, F Ruschitzka, N Hamdani, S Costantino, F Paneni

European Heart Journal (Oxford Academic) , 09 November 2023

Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling

Q Wang, H Lin, C Shen, M Zhang, X Wang, M Yuan, M Yuan, S Jia, Z Cao, C Wu, B Chen, A Gao, Y Bi, G Ning, W Wang, J Wang, R Liu

Gut Microbes (Taylor & Francis) China, 09 November 2023

Gastroenterology

Key words: Microbiome, GLP-1, bile acid, TGR5, ileum, diabetes [more]

Autopsy analysis reveals increased macrophage infiltration and cell apoptosis in COVID-19 patients with severe pulmonary fibrosis

SQ Xiao, TZ Wen, XY Chen, HY Chen, Z Li, ZC He, T Luo, R Tang, WJ Fu, MF Cao, L Chen, Q Niu, S Wang, Y Lan, J Ge, QR Li, HT Guo, YX Wang, YF Ping, H Shen, Y Wang, YQ Ding, XW Bian, XH Yao

Pathology - Research and Practice (Elsevier) China, 08 November 2023

Virology

Key words: COVID-19, Respiratory failure, Histopathology, Macrophage, Apotosis [more]

Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K

Y Miyahara, H Chen, M Moriyama, K Mochizuki, N Kaneko, AR Haque, A Chinju, K Kai, M Sakamoto, N Kakizoe-Ishiguro, M Yamauchi, K Ogata, T Kiyoshima, S Kawano, S Nakamura

Scientific reports (Nature) Japan, Bangladesh, 07 November 2023

Immunology, Dermatology

Key words: Inflammation, Innate immunity, Lymphocytes, Mucosal immunology [more]

Use of Atrial Fibrillation Electrograms and T1/T2 Magnetic Resonance Imaging to Define the Progressive Nature of Molecular and Structural Remodeling–A New Paradigm Underlying the Emergence of Persistent Atrial Fibrillation

M Rottmann, S Yoo, A Pfenniger, A Mikhailov, B Benefield, DA Johnson, W Zhang, AK Ghosh, D Kim, R Passman, BP Knight, DC Lee, R Arora

Journal of the American Heart Association (AHA) USA, 06 November 2023

Cardiology

Key words: Atrial Fibrillation, Electrophysiology, Fibrosis, Magnetic Resonance Imaging (MRI), Oxidant Stress [more]

A novel lncRNA GM15416 regulates osteoblast apoptosis and differentiation through the c-Fos/Fas axis and mitigates osteoporosis

D Zhao, J He, X Zhao, X Sheng, Z Feng, X Wang, C Zhang, S Wang, B Geng, Y Xia

International Journal of Biological Macromolecules (Elsevier) China, 02 November 2023

Osteology

Key words: lncRNA GM15416, C-Fos, Osteoporosis [more]

Heterogeneity of Phase II Enzyme Ligands on Controlling the Progression of Human Gastric Cancer Organoids as Stem Cell Therapy Model

DC Wu, CC Ku, JB Pan, K Wuputra, YH Yang, CJ Liu, YC Liu, K Kato, S Saito, YC Lin, IW CHong, M Hsiao, HM Hu, CH Kuo, KK Kuo, CS Lin, KK Yokoyama

International Journal of Molecular Sciences (MDPI) Taiwan, 02 November 2023

Oncology, Stem Cell Research

Key words: cinnamaldehyde; gastric cancer development; organoids; perillaldehyde; reactive oxygen species [more]

Topical application of synthetic melanin promotes tissue repair

D Biyashev, ZE Siwicka, UV Onay, M Demczuk, D Xu, MK Ernst, ST Evans, CV Nguyen, FA Son, NK Paul, NC McCallum, OK Farha, SD Miller, NC Gianneschi, KQ Lu

NPJ Regenerative Medicine (Nature) USA, 02 November 2023

Dermatology

Key words: Biomaterials, Cell death and immune response, Trauma [more]

Group 3 innate lymphoid cells exacerbate lupus nephritis by promoting B cell activation in kidney ectopic lymphoid structures

F Li, Z Liang, H Zhong, X Hu, Z Tang, C Zhu, J Shen, X Han, R Lin, R Zheng, R Tang, H Peng, X Zheng, C Mo, P Chen, X Wang, Q Wen, J Li, X Xia, H Ye, Y Qiu, J Yu, D Fu, J Liu, R Wang, H Xie, Y Guo, X Li, J Fan, Q Liu, H Mao, W Chen, Y Zhou

Advanced Science (Wiley) China, 01 November 2023

Nephrology

[more]

Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene

Q Sun, D Liu, W Cui, H Cheng, L Huang, R Zhang, J Gu, S Liu, X Zhuang, Y Lu, B Chu, J Li

Communications Biology (Nature) China, 01 November 2023

Metabolism

Key words: Lipid peroxides, Sterols [more]

Estrogen-related genes for thyroid cancer prognosis, immune infiltration, staging, and drug sensitivity

L Zhang, M Zhou, X Gao, Y Xie, J Xiao, T Liu, X Zeng

BMC Cancer (BMC) China, 31 October 2023

Oncology

Key words: Estrogen-related genes, Estrogen-related differential expressed genes, Progression-free interval, Thyroid cancer, Immune infiltration, Clinical relevance, Drug sensitivity [more]

CD24hiCD27+ Bregs within metastatic lymph nodes promote multi-drug resistance in breast cancer

H Huang, Y Yao, L Shen, J Jiang, T Zhang, J Xiong, J Li, S Sun, S Zheng, F Jia, J Zhou, X Yu, W Chen, J Shen, W Xia, X Shao, Q Wang, J Huang, C Ni

Clinical Cancer Research (AACR) China, 31 October 2023

Oncology, Pharmacology

[more]

EXOSC5 maintains cancer stem cell activity in endometrial cancer by regulating the NTN4/integrin β1 signalling axis

YH Huang, WL Wang, PH Wang, HT Lee, WW Chang

International Journal of Biological Sciences (Ivy SPring) Taiwan, 31 October 2023

Oncology, Stem Cell Research

Key words: Endometrial carcinoma, cancer stem cells, c-MYC, EXOSC5, NTN4, integrin β1 [more]

Antigen-caged-adjuvant nanovaccines elicit potent humoral and cellular immune responses

K Chen, Z Zhang, J Zhang, Z Fang, W Dong, Y Wang, M Li

Nano Today (Elsevier) China, 31 October 2023

Immunology, Nanomedicine

[more]

Tumor-infiltrating platelets promote the growth of lung adenocarcinoma

X Li, M Li, Z Hu, L Zhou, M Zheng, D Jiao, J Qin, B Fu, X Zheng, H Wei

Translational Oncology (Elsevier) China, 27 October 2023

Oncology

Key words: NSCLC, Lung adenocarcinoma, Tumor-infiltrating platelets, Fibrinogen, Coagulation [more]

Acidosis promotes the metastatic colonization of lung cancer via remodeling of the extracellular matrix and vasculogenic mimicry

WY Shie, PH Chu, MYP Kuo, HW Chen, MT Lin, XJ Su, YL Hong, HYE Chou

International Journal of Oncology (Spandios Publications) Taiwan, 26 October 2023

Oncology

[more]

Dual antibody-aided mesoporous nanoreactor for H2O2 self-supplying chemodynamic therapy and checkpoint blockade immunotherapy in triple-negative breast cancer

YT Chen, YX Luo, SH Chan, WY Chiu, HWW Yang

Journal of Nanobiotechnology (Springer) Taiwan, 24 October 2023

Oncology, Pharmacology

Key words: Triple-negative Breast cancer (TNBC), Mesoporous nanoreactors, Chemodynamic therapy (CDT), Checkpoint blockade immunotherapy, Collaborative treatment [more]

Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imaging

DE Cohn, A Forder, EA Marshall, EA Vucic, GL Stewart, K Noureddine, WW Lockwood, CE MacAulay, M Guillaud, WL Lam

Frontiers in Immunology (Frontiers Media S.A.) Canada, USA, 23 October 2023

Oncology, Bioimaging

Key words: tumor immune microenvironment (TIME), tumor microenvironment (TME), tumor-infiltrating lymphocytes, immune checkpoint blockade, non-cell autonomous interactions, multiplexed imaging

Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice

AM Schmid, A Razim, M Wysmołek, D Kerekes, M Haunstetter, P Kohl, G Brazhnikov, N Geissler, M Thaler, E Krčmářová, M Šindelář, T Weinmayer, J Hrdý, K Schmidt, P Nejsum, B Whitehead, J Palmfeldt, S Schild, A Inić-Kanada, U Wiedermann, I Schabussova

Cell Communication and Signaling (Springer) Austria, Poland, Czech Republic, Denmark, 20 October 2023

Immunology

Key words: Allergic airway inflammation, Extracellular vesicles, Outer membrane vesicles, Microbiota and innate immunity, Nasal route of administration [more]

Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development

T Vanova, J Sedmik, J Raska, KA Cerna, P Taus, V Pospisilova, M Nezvedova, V Fedorova, S Kadakova, H Klimova, M Capandova, P Orviska, P Fojtik, S Bartova, K Plevova, Z Spacil, H Hribkova, D Bohaciakova

Cell Reports (Cell Press) Czech Republic, 20 October 2023

Neuroscience

[more]

Proteomic profiling of advanced melanoma patients to predict therapeutic response to anti-PD-1 therapy

N Zila, OM Eichhoff, I Steiner, T Mohr, A Bileck, PF Cheng, A Leitner, L Gillet, T Sajic, S Goetze, B Friedrich, P Bortel, J Strobl, R Reitermaier, SA Hogan, JM Martínez-Gómez, R Staeger, F Tuchmann, S Peters, G Stary, M Kuttke, A Elbe-Buerger, C Hoeller, R Kunstfeld, W Weninger, B Wollscheid, R Dummer, LE French, C Gerner, R Aebersold, MP Levesque, V Paulitschke

Clinical Cancer Research (AACR) Austria, Switzerland, Germany, 20 October 2023

Oncology, Pharmacology

Key words: Predictive biomarker, Immunotherapy, Serum depletion, Glycoproteomics, SWATH/DIA mass spectrometry [more]

TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD

L Sun, Y Chen, L Xia, J Wang, J Zhu, J Li, K Wang, K Shen, D Zhang, G Zhang, T Shi, W Chen

Oncogene (Nature) China, 20 October 2023

Oncology

Key words: Apoptosis, Extracellular matrix, Gastric cancer, Ubiquitylation [more]

Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma

Z Cai, L Chen, S Chen, R Fang, X Chen, W Lei

Cell Communication and Signaling (Springer) China, 18 October 2023

Oncology

Key words: Single-cell RNA sequencing, Hypopharyngeal squamous cell carcinoma, Tumor microenvironment, Extracellular matrix cancer-associated fibroblast, Precision therapy [more]

Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization

CY Ko, YY Lin, D Achudhan, JW Chang, SC Liu, CY Lai, YL Huang, CH Tsai, YC Fong, HT Chen, KT Lee, CC Huang, TK Chang, CH Tang

International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan, 18 October 2023

Osteology, Immunology

Key words: Omentin-1, Osteoarthritis, IL-4, M2 macrophage, Anti-inflammation [more]

Effect of the Functional VP1 Unique Region of Human Parvovirus B19 in Causing Skin Fibrosis of Systemic Sclerosis

DY Chen, CC Tzang, CM Liu, TM Chiu, JW Lin, PH Chuang, CW Kuo, BS Tzang, TC Hsu

International Journal of Molecular Sciences (MDPI) Taiwan, 18 October 2023

Dermatology

Key words: human parvovirus B19 (B19), systemic sclerosis (SSc), VP1 unique region (VP1u), macrophages, fibrosis [more]

Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate

O Ertunc, E Smearman, Q Zheng, JL Hicks, JA Brosnan-Cashman, T Jones, C Gomes-Alexandre, L Trabzonlu, AK Meeker, AM De Marzo, CM Heaphy

The Prostate (Wiley) USA, 17 October 2023

Oncology

Key words: chromogenic, diagnostic, in situ hybridization, prostate cancer, telomeres [more]

Danggui Shaoyao San ameliorates the lipid metabolism via the PPAR signaling pathway in a Danio rerio (zebrafish) model of hyperlipidemia

Y Wang, Y Pan, M Hou, R Luo, J He, F Lin, X Xia, P Li, C He, P He, S Cheng, Z Song

Biomedicine & Pharmacotherapy (Elsevier) China, 16 October 2023

Endocrinology

Key words: Danggui Shaoyao San, Hyperlipidemia, PPAR signaling pathway, Danio rerio, Lipid metabolism [more]

Role for NLRP3 inflammasome-mediated, Caspase1-dependent response in glaucomatous trabecular meshwork cell death and regulation of aqueous humor outflow

X Feng, Z Chen, W Cheng, C Liu, Q Liu

Heliyon (Cell) China, 15 October 2023

Ophthalmology

Key words: Pyroptosis, NLRP3, ROS, Glaucoma, Human trabecular meshwork cell [more]

Light damage induces inflammatory factors in mouse retina and vitreous humor

W Liu, X Zhu, X Ge, Y Chen, DWC Li, L Gong

Molecular Vision (Emory University) China, 15 October 2023

Ophthalmology

[more]

Hypoxic microenvironment determines the phenotypic plasticity and spatial distribution of cancer‐associated fibroblasts

JI Choi, EJ Cho, MJ Yang, HJ Noh, SH Park, S Kim, YS Kim, CO Sung, D Lee

Clinical and Translational Medicine (ncbi.nlm.nih.gov) South Korea, 14 October 2023

Oncology

[more]

Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland

Z Wang, L Zhang, B Li, J Song, M Yu, J Zhang, C Chen, J Zhan, H Zhang

Cell Death & Disease (Nature) China, 13 October 2023

Reproductive Medicine

Key words: Cell signalling, Differentiation [more]

A marmoset brain cell census reveals regional specialization of cellular identities

FM Krienen, KM Levandowski, H Zaniewski, RCH Del Rosario, ME Schroeder, M Goldman, M Weinisch, A Lufservitz, VF Beja-Glasser, C Chen, Q Zhang, KY Chan, KX Li, J Sharma, D McCormack, TW Shin, A Harrahill, E Nyase, G Mudhar, A Mauermann, A Wysoker, J Nemesh, S Kashin, J Vergara, G Chelini, J Dimidschstein, S Berretta, BE Deverman, E Boyden, SA McCarroll, G Feng

Science Advances (Science) USA, Italy, 12 October 2023

Neuroscience, Zoology

[more]

A molecular landscape of quiescence and proliferation highlights the role of Pten in mammary gland acinogenesis

R Tomasin, AM Rodrigues, AC Manucci, A Bruni-Cardoso

Journal of Cell Science (The Company of Biologists) Brazil, 11 October 2023

Cell Biology

Key words: Pten, Basement membrane, Cell cycle, Extracellular matrix, Mammary gland acinogenesis, Quiescence [more]

Donor bone marrow–derived macrophage engraftment into the central nervous system of patients following allogeneic transplantion

AM Loeb, SS Pattwell, S Meshinchi, A Bedalov, KR Loeb

Blood Advances (ASH Publications) USA, 10 October 2023

Hematology

Key words: Immunobiology and Immunotherapy, Transplantation [more]

Novel ratio-expressions of genes enables estimation of wound age in contused skeletal muscle

N Li, X Liang, X Bai, X Liang, L Dang, Q Jin, J Cao, QX Du, JH Sun

International Journal of Legal Medicine (Springer) China, 07 October 2023

Osteology

Key words: Ratio-expressions of genes, Real-time PCR, Wound age estimation, Skeletal muscle [more]

Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition

A Yu, J Hu, L Fu, G Huang, D Deng, M Zhang, Y Wang, G Shu, L Jing, H Li, X Chen, T Yang, J Wei, Z Chen, X Zu

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 06 October 2023

Oncology

[more]

Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition

A Yu, J Hu, L Fu, G Huang, D Deng, M Zhang, Y Wang, G Shu, L Jing, H Li, X Chen, T Yang, J Wei, J Luo

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 06 October 2023

Oncology

Key words: Tumor Microenvironment, Immunotherapy, Urinary Bladder Neoplasms [more]

A comprehensive strategy to strengthen bioimaging in Africa through the Africa Microscopy Initiative

MA Reiche, CA Jacobs, JS Aaron, V Mizrahi, DF Warner, TL Chew

Nature Cell Biology (Nature) South Africa, USA, 06 October 2023

Bioimaging

Key words: Imaging, Microscopy

Local reference values ​​for tissue characterization by cardiac magnetic resonanceimaging. Myocardial mapping using parametric sequences

L Gutiérrez, SA Tejera, AL Ortego, CR Secotaro, J Nerviani, JA Cubillos, JC Daza, JE Briggs, P Briggs, FA Peñafort

Revista de la Federación Argentina de Cardiología (Federación Argentina de Cardiología) Argentina, 06 October 2023

Cardiology

Key words: Tissue Characterization,T1 Mapping, T2 Mapping,extracellular volume

Acrylamide, an Air Pollutant, Enhances Allergen-Induced Eosinophilic Lung Inflammation via Group 2 Innate Lymphoid Cells

HH Su, CM Cheng, YN Yang, YW Chang, CY Li, ST Wu, CC Lin, HE Wu, JL Suen

Mucosal Immunology (Elsevier) Taiwan, 05 October 2023

Allergy Research

Key words: Acrylamide, Air pollutant, Asthma, Eosinophilic Inflammation, Group 2 innate lymphoid cell [more]

A comprehensive strategy to strengthen bioimaging in Africa though the Africa Microscopy Initiative

MA Reiche, CA Jacobs, JS Aaron, V Mizrahi, DF Warner, TL Chew

Nature Cell Biology (Nature) South Africa, 05 October 2023

Key words: Imaging, Microscopy

Development of an image processing software for quantification of histological calcification staining images

X Li, YT Chan, Y Jiang

PloS one (PLOS) China, 05 October 2023

Medical Image Analysis

Key words: Alizarin staining, Histology, Imaging techniques, Calcification, Cell staining, Hematoxylin staining, Staining Stem cells

The RBPMSCreERT2-tdTomato mouse line for studying retinal and vascular relevant diseases

G Li, Y Luo, Q Zhang, W Chen, K Lai, Y Liu, Y Zheng

Iscience (Cell Press) China, 02 October 2023

Biological Methods

Key words: Natural sciences, Biological sciences, Physiology, Biological sciences research methodologies [more]

Transitional Selves

M Chakravorty

api.taylorfrancis.com () , 01 October 2023

Donor bone marrow–derived macrophage engraftment into the central nervous system of patients following allogeneic transplantation

AM Loeb, SS Pattwell, S Meshinchi, A Bedalov, KR Loeb

Blood Advances (ASH Publications) USA, 29 September 2023

Transplantation Medicine

Key words: Immunobiology and Immunotherapy, Transplantation [more]

Activation of the p62-Keap1-Nrf2 pathway protects against oxidative stress and excessive autophagy in ovarian granulosa cells to attenuate DEHP-induced ovarian impairment in mice

B Xu, T He, H Yang, W Dai, L Liu, X Ma, J Ma, G Yang, R Si, X Du, X Fu, X Pei

Ecotoxicology and Environmental Safety (Elsevier) China, 28 September 2023

Toxicology, Reproductive Medicine

Key words: Di-(2-ethylhexyl) phthalate, Female reproductive toxicity, Ovarian granulosa cells, Excessive autophagy, Oxidative stress, P62-Keap1-Nrf2 pathway [more]

Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice

L Yang, P Lu, X Qi, Q Yang, L Liu, T Dou, Q Guan, C Yu

Iscience (Elsevier) China, 27 September 2023

Endocrinology

Key words: Physiology, Molecular biology, Neuroscience, Immunology [more]

A comparative analysis of microglial inducible Cre lines

TE Faust, PA Feinberg, C O'Connor, R Kawaguchi, A Chan, H Strasburger, M Frosch, MA Boyle, T Masuda, L Amann, KP Knobeloch, M Prinz, A Schaefer, DP Schafer

Cell Reports (Cell Press) USA, Germany, Japan, 26 September 2023

Neuroscience

Key words: Microglia, Cre/LoxP, CreER, recombination [more]

Ex Vivo Evaluation of Combination Immunotherapy Using Tumor‐Microenvironment‐on‐Chip

HY Mu, CM Lin, LA Chu, YH Lin, J Li, CY Liu, HC Huang, SL Cheng, TY Lee, HM Lee, HM Chen, YJ Tsai, Y Chen, JH Huang

Advanced Healthcare Materials (Wiley) Taiwan, 25 September 2023

Pharmacology, Oncology

ROCK inhibition reduces the sensitivity of mutant p53 glioblastoma to genotoxic stress through a Rac1-driven ROS production

YT Magalhaes, FL Forti

The International Journal of Biochemistry & Cell Biology (Elsevier) Austria, 23 September 2023

Immunology, SARS-CoV-2

Key words: Neutrophil Extracellular Traps, Oxidative Stress, Post-Acute COVID-19 Syndrome, Thromboinflammation, Thrombosis [more]

STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma

L Wang, QF Zhao, BB Yang, HJ Liang, XE Zhang, XY Zhang, WJ Yang, ZY Guo, X Xu, F Tian, QH Wu

Acta Oncologica (Taylor & Francis) China, 22 September 2023

Oncology

Key words: STAT3, EphA7, transcription, ESCC, promoter [more]

Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D

M Liu, L Liu, H Guo, X Fan, T Liu, C Xu, Z He, Y Song, L Gao, S Shao, J Zhao, P Lu

iScience (Cell Press) China, 22 September 2023

Hepathology

Effect of different sperm populations on neutrophils extracellular traps (NETs) formation in cattle

R Rivera-Concha, C Moya, M León, P Uribe, M Schulz, A Prado, A Taubert, C Hermosilla, R Sánchez, F Zambrano

Research in Veterinary Science (Elsevier) Chile, Germany, 22 September 2023

Zoology, Reproductive Medicine

Key words: Bovine, Spermatozoa, Neutrophil extracellular traps, Sperm motility [more]

Optimising multiplex immunofluorescence staining for characterising the tumour immune micro-environment

R Cohen, T Lee-Pullen, TJ Miller, K Meehan, K Fuller, MJ McCoy

Methods (Elsevier) Australia, 21 September 2023

Microscopy

Key words: Colorectal cancer, Multiplex immunofluorescence, Automated staining, Tumor immune microenvironment [more]

Platinum-Based Twin Drug Modulates Tumor-Infiltrating Immune Cells to Improve Immune Checkpoint Blockade Therapy

Y Hao, R Li, Y Min

Journal of Medicinal Chemistry (ACS Publications) China, 20 September 2023

Oncology, Immunology

[more]

The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

NN Liu, CX Yi, LQ Wei, JA Zhou, T Jiang, CC Hu, L Wang, YY Wang, Y Zou, YK Zhao, LL Zhang, YT Nie, YJ Zhu, XY Yi, LB Zeng, JQ Li, XT Huang, HB Ji, Z Kozlakidis, L Zhong, C Heeschen, XQ Zheng, C Chen, P Zhang, H Wang

Cancer Cell (Cell Press) China, France, 19 September 2023

Oncology

Key words: Aspergillus, CARD9, IL-1β, β-glucan, Intratumor mycobiome, Lung adenocarcinoma, Myeloid-Derived Suppressor Cells. [more]

Propolis as a Potential Therapeutic Agent to Counteract Age-Related Changes in Cartilage: An In Vivo Study

C Arias, B Vásquez, LA Salazar

International Journal of Molecular Sciences (MDPI) Chile, 19 September 2023

Rheumatology

Key words: Osteoarthritis, Propolis, Aging [more]

Impact of Perinatal Coexposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs

M Lahimer, N Djekkoun, S Tricotteaux-Zarqaoui, A Corona, I Lafosse, HB Ali, M Ajina, V Bach, M Benkhalifa, H Khorsi-Cauet

Toxics (MDPI) France, Tunisia, 19 September 2023

Reproductive Medicine, Endocrinology

Key words: chlorpyrifos, high-fat diet, Kisspeptin, GnRHR, ovary, testis, rat [more]

Postirradiation temperature influences DSB repair and dicentric chromosome formation—potential impact for dicentric chromosome analysis in interlaboratory comparisons

C Beinke, M Port, H Scherthan

Radiation Protection Dosimetry (Oxford Academic) Germany, 18 September 2023

Radiotherapy

[more]