Customer Publications (A total of 2946 papers published)

Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients

YT Wu, HY Tay, JT Yang, HH Liao, YS Ma, YH Wei

Journal of Biomedical Science (Springer) Taiwan, 09 September 2023

Neuroscience

Key words: AMPARs, Disease modeling, Electrophysiological activity, Excitatory neurons, iPSCs, MERRF syndrome, mtDNA mutation, Neurological defect, Synaptic plasticity, Synaptophysin [more]

Formin protein FMNL1 is a biomarker for tumor-infiltrating immune cells and associated with well immunotherapeutic response

G Lu, H Wang, R Xu, J Xu, F An, H Xu, H Nie, J Mei, Q Zhan, Q Zhang

Journal of Cancer (Ivyspring International Publisher) China, 09 September 2023

Oncology

Key words: FMNL1, bioinformatics, biomarker, cancer, mQIF [more]

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

C Li, Y Lin, Y Chen, X Song, X Zheng, J Li, J He, X Chen, C Huang, W Wang, J Wu, J Wu, J Gao, Z Tu, XJ Li, S Yan, S Li

Advanced Science (Wiley) China, 08 September 2023

Neuroscience, Cell Biology

Key words: HD KI-140Q mice, intravenous injection, lysosome, mini-intrabody, mu-tant huntingtin, SM3, stereotaxic injection [more]

Neutrophil extracellular traps are involved in the occurrence of interstitial lung disease in a murine experimental autoimmune myositis model

L Bai, J Zhu, W Ma, F Li, P Zhao, S Zhang

Clinical and Experimental Immunology (Oxford Academic) China, 08 September 2023

Immunology

Key words: idiopathic inflammatory myopathy (IIMs), experimental autoimmune myositis (EAM), interstitial lung disease (ILD), neutrophil extracellular traps (NETs) [more]

Genomic and Phenotypic Biomarkers for Precision Medicine Guidance in Advanced Prostate Cancer

F Davoudi, A Moradi, TM Becker, JG Lock, B Abbey, D Fontanarosa, A Haworth, J Clements, RC Ecker, J Batra

Current Treatment Options in Oncology (Springer) Australia, Iran, Austria, 08 September 2023

Oncology

Key words: Advanced prostate cancer, Genotypic biomarkers, Phenotypic biomarkers, Precision medicine

Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors

Y Chen, T Yamamoto, Y Takahashi, T Moro, T Tajima, Y Sakaguchi, N Sakata, A Yokoyama, S Hijioka, A Sada, Y Tabata, R Ohki

Cell Death & Disease (Nature) Japan, 07 September 2023

Oncology, Endocrinology

Key words: Cancer models, Neuroendocrine cancer [more]

Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC

X Zhou, J An, R Kurilov, B Brors, K Hu, T Peccerella, S Roessler, K Pfütze, A Schulz, S Wolf, N Hohmann, D Theile, M Sauter, J Burhenne, S Ei, U Heger, O Strobel, ST Barry, C Springfeld, C Tjaden, F Bergmann, M Büchler, T Hackert, F Fortunato, JP Neoptolemos, P Bailey

Nature Cancer (Nature) Germany, Japan, Austria, UK, Portugal, 07 September 2023

Oncology

Key words: Cancer, Pancreatic cancer, Tumour biomarkers [more]

Correlation of tumor-associated macrophage infiltration in glioblastoma with magnetic resonance imaging characteristics: a retrospective cross-sectional study

Q Zhou, C Xue, J Man, P Zhang, X Ke, J Zhao, B Zhang, J Zhou

Quantitative Imaging in Medicine and Surgery (AME Publishing Company) China, 07 September 2023

Oncology, Microscopy

Key words: Glioblastoma (Gb), tumor-associated macrophage (TAM), magnetic resonance imaging (MRI), tumor microenvironment [more]

PTBP1 plays an important role in the development of gastric cancer

Z Chu, M Zhu, Y Luo, Y Hu, X Feng, H Wang, M Sunagawa, Y Liu

Cancer Cell International (BMC) China, Japan, 05 September 2023

Oncology

Key words: PTBP1:Polypyrimidine Tract binding protein 1, Gastric cancer, Proliferation, Actin cytoskeleton remodeling, PTBP1 Cas9-KO mouse model [more]

Genomic and Transcriptomic Landscape of an Oral Squamous Cell Carcinoma Mouse Model for Immunotherapy

YM Lee, CL Hsu, YH Chen, DL Ou, C Hsu, CT Tan

Cancer Immunology Research (AACR) Taiwan, 05 September 2023

Oncology, Immunology

[more]

Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activation

CJ Shen, RH Chan, BW Lin, NC Li, YH Huang, WC Chang, BK Chen

Theranostics (Ivyspring International Publisher) Taiwan, 05 September 2023

Oncology

Key words: multigene mutant CRC, oleic acid, IL-8, KRAS activation, metastasis [more]

SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells

Y Wang, JM Wang, Y Xiao, XB Hu, SY Zheng, JL Fu, L Zhang, YW Gan, XM Liang, DWC Li

Aging (Impact Journals) China, 04 September 2023

Ophthalmology

Key words: lens, cataract, apoptosis, DBC1, p53, oxidative stress [more]

The combination of NDUFS1 with CD4+ T cell infiltration predicts favorable prognosis in kidney renal clear cell carcinoma

D Wu, L He, Z Xu, RF Tian, XY Fan, J Fan, J Ai, HJ Bian, WJ Qin, J Qin, L Li

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 04 September 2023

Nephrology

Key words: kidney renal clear cell carcinoma, NDUFS1, survival, hsa-miR-320b, CD4+ T cell infiltration [more]

Platinum Twin and Triplet Drugs Improve Chemoimmunotherapy

Y Hao, R Li, W Pan, S Tian, Y Min

Journal of Medicinal Chemistry (ACS Publications) China, USA, 04 September 2023

Oncology, Pharmacology

[more]

NETs induce persistent lung tissue damage via thromboinflammation without altering virus resolution in a mouse coronavirus model

M Salzmann, P Gibler, P Haider, M Brekalo, R Plasenzotti, T Filip, R Nistelberger, B Hartmann, J Wojta, C Hengstenberg, BK Podesser, JB Kral-Pointer, PJ Hohensinner

Journal of Thrombosis and Haemostasis (Elsevier) Austria, 04 September 2023

Pulmonology, Immunology, SARS-CoV-2

Key words: Neutrophil Extracellular Traps, Oxidative Stress, Post-Acute COVID-19 Syndrome, Thromboinflammation, Thrombosis [more]

Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

X Zheng, C Huang, Y Lin, B Han, Y Chen, C Li, J Li, Y Ding, X Song, W Wang, W Liang, J Wu, J Wu, J Gao, C Wei, X Zhang, T Zhuchi, Y Sen

Signal Transduction and Targeted Therapy (Nature) China, 04 September 2023

Genetics

Key words: Experimental models of disease, Genetic engineering [more]

Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4+ T cells through regulating type 2 conventional dendritic cells

J Luo, S Pang, Z Hui, H Zhao, S Xu, W Yu, L Yang, Q Sun, X Hao, F Wie, J Wang, X Ren

Theranostics (Ivyspring) China, 04 September 2023

Oncology, Pharmacology

Key words: STING, ADU-S100, Tim-3, DC, Cancer immunotherapy [more]

Anti-tumor effects of deubiquitinating enzyme inhibitor PR-619 in human chondrosarcoma through reduced cell proliferation and endoplasmic reticulum stress-related apoptosis

WC Lin, YL Chiu, KL Kuo, PM Chow, CH Hsu, SM Liao, JR Dong, SC Chang, SW Liu, TJ Liu, FS Hsu, KC Wang, YC Lin, CC Chang, KY Huang

American Journal of Cancer Research (e-Century Publishing) Taiwan, 03 September 2023

Oncology

Key words: Deubiquitinating enzyme, chondrosarcoma, apoptosis, endoplasmic reticulum stress [more]

Plasmon-activated water as a therapeutic strategy in Alzheimer's disease by altering gut microbiota

CH Cheng, YC Liu, YCSH Yang, KJ Lin, D Wu, YR Liu, CC Chang, CT Hong, CJ Hu

Aging (Impact Journals) Taiwan, 02 September 2023

Neuroscience, Gastroenterology

Key words: Alzheimer’s disease, plasmon-activated water, fecal microbiota transplantation, microbiota, beta amyloid, tau [more]

Impact of apolipoprotein A1 on tumor immune microenvironment, clinical prognosis and genomic landscape in hepatocellular carcinoma

Y Wang, S Chen, X Xiao, F Yang, J Wang, H Zong, Y Gao, C Huang, X Xu, M Fang, X Zhang, C Gao

Precision Clinical Medicine (Oxford Academic) China, The Netherlands, 02 September 2023

Oncology

[more]

Mesenchymal stem cells promote polarization of M2 macrophages in mice with acute-on-chronic liver failure via Mertk/JAK1/STAT6 signaling

Z Li, J Chen, J Zhang, Z Lei, L Wu, S Meng, J Wang, J Xiong, DN Lin, Jz Wang, ZL Gao, BL Lin

Stem Cells (Oxford Academic) China, 02 September 2023

Stem Cell Research, Hepathology

Key words: mesenchymal stem cell, acute-on-chronic liver failure, macrophage, polarization, Mertk, JAK1/STAT6 [more]

Escherichia coli adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4

W Zhang, L Xu, X Zhang, J Xu, JO Jin

Frontiers in Immunology (Frontiers Media S.A.) China, South Korea, 01 September 2023

Immunology

Key words: fimH, macrophage polarization, toll-like receptor 4, myeloid differentiation factor 2, tumor-associated macrophage [more]

Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma

L Pang, M Dunterman, S Guo, F Khan, Y Liu, E Taefi, A Bahrami, C Geula, WH Hsu, C Horbinski, CD James, P Chen

Nature Immunology (Nature) USA, 31 August 2023

Oncology, Immunology

Key words: Cancer immunotherapy, Immunosurveillance, Stem cells, Tumour immunology [more]

The Cooperative Human Tissue Network of the National Cancer Institute: Supporting cancer research for 35 years

SJ McCall, IA Lubensky, CA Moskaluk, A Parwani, K Radin, NC Ramirez, Z Von Menchhofen, MK Washington, VA LiVolsi

Molecular Cancer Therapeutics (AACR) USA, 30 August 2023

Oncology

Engineering tumoral vascular leakiness with gold nanoparticles

MI Setyawati, Q Wang, N Ni, JK Tee, K Ariga, PC Ke, HK Ho, Y Wang, DT Leong

Nature Communications (Nature) Singapore, China, Japan, Australia, 30 August 2023

Oncology, Nanomedicine

Key words: Cancer, Nanoscale materials [more]

FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth

M Yu, W Wu, Y Sun, H Yan, L Zhang, Z Wang, Y Gong, T Wang, Q Li, J Song, M Wang, J Zhang, Y Tang, J Zhan, H Zhang

Cell Reports (Cell Press) China, 29 August 2023

Oncology

Key words: CDK4, CP: Cancer, CP: Molecular biology, CRC, FRMD8, MDM2, RB. [more]

Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling

L Chen, L Zhang, G Jin, Y Liu, N Guo, H Sun, Y Jiang, X Zhang, G He, G Lv, J Yang, X Tu, T Dong, H Liu, J An, G Si, Z Kang, H Li, S Yi, G Chen, W Liu, Y Yang, J Ou

Cell Reports (Cell Press) China, 29 August 2023

Hepathology

Key words: 5-aminolevulinate, CP: Immunology, CP: Metabolism, CX3CR1, P53, hepatectomy, hepatocyte proliferation, insulin-like growth factor 1, liver regeneration, liver zonation, macrophage polarization, partial liver transplantation [more]

Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

X Ma, Q Wang, C Sun, I Agarwal, H Wu, J Chen, C Zhao, G Qi, Q Teng, C Yuan, S Yan, J Peng, R Li, K Song, Q Zhang, B Kong

Cell Reports (Cell Press) China, 29 August 2023

Oncology, Immunology

Key words: IFN-β signaling, T cell exhaustion, TCF19, endometrial cancer, immune checkpoint blockade therapy, microsatellite instable [more]

Single-cell transcriptomics reveals granzyme K–expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD

R Aoyagi, T Maehara, R Koga, R Munemura, T Tomonaga, Y Murakami, A Doi, H Yamamoto, T Kiyoshima, S Kawano, S Nakamura

Journal of Allergy and Clinical Immunology (Elsevier) Japan, 29 August 2023

Immunology

Key words: Single-cell RNA sequencing, IgG4-related disease, germinal center, granzyme K, T follicular helper cells, T follicular regulatory cells [more]

The rs1421085 variant within FTO promotes brown fat thermogenesis

Z Zhang, N Chen, N Yin, R Liu, Y He, D Li, M Tong, A Gao, P Lu, Y Zhao, H Li, J Zhang, D Zhang, W Gu, J Hong, W Wang, L Qi, G Ning, J Wang

Nature Metabolism (Nature) China, USA, 29 August 2023

Endocrinology

Key words: Fat metabolism, Genome-wide association studies, Mechanisms of disease [more]

Mitochondrial integrated stress response controls lung epithelial cell fate

SH Han, M Lee, Y Shin, R Giovanni, RP Chakrabarty, MM Herrerias, LA Dada, AS Flozak, PA Reyfman, B Khuder, CR Reczek, L Gao, J Lopéz-Barneo, CJ Gottardi, GR Scott Budinger, NS Chandel

Nature (Nature) USA, South Korea, Spain, 28 August 2023

Pulmonology

Key words: Differentiation, Metabolomics [more]

Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4+ T cells through regulating type 2 conventional dendritic cells

J Luo, S Pang, Z Hui, H Zhao, S Xu, W Yu, L Yang, Q Sun, X Hao, F Wei, J Wang, X Ren

Theranostics (Ivyspring International Publisher) China, 25 August 2023

Oncology, Immunology

Key words: STING, ADU-S100, Tim-3, DC, Cancer immunotherapy [more]

Anti-angiogenic therapy using the multi-tyrosine kinase inhibitor Regorafenib enhances tumor progression in a transgenic mouse model of ß-cell carcinogenesis

MJ Egidi, S Krug, J Haybaeck, P Michl, H Griesmann

British Journal of Cancer (Nature) Germany, Austria, 24 August 2023

Oncology

Key words: Pancreatic cancer, Target validation, Tumour angiogenesis [more]

Clinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence

Y Zhang, Y Bai, XX Ma, JK Song, Y Luo, XY Fei, Y Ru, Y Luo, JS Jiang, Z Zhang, D Yang, TT Xue, HP Zhang, TY Liu, YW Xiang, L Kuai, YQ Liu, B Li

Cell Death & Disease (Nature) China, 24 August 2023

Oncology

Key words: Melanoma, Prognostic markers [more]

PNU-74654 Induces Cell Cycle Arrest and Inhibits EMT Progression in Pancreatic Cancer

TL Chien, YC Wu, HL Lee, WW Sung, CY Yu, YC Chang, CC Lin, CC Wang, MC Tsai

Medicina (MDPI) Taiwan, 24 August 2023

Oncology, Pharmacology

Key words: pancreatic adenocarcinoma, β-catenin, WNT, cell cycle arrest, migration [more]

Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress

ZY Yang, XC Yan, L Liang, CC Gao, PR Zhang, Y Liu, JX Sun, B Ruan, JL Duan, RN Wang, XX Feng, B Che T Xiao, H Han

The Journal of Clinical Investigation (Am Soc Clin Investig) China, 22 August 2023

Oncology

Key words: SPEN, rDNA, nucleolar stress, pRNA, endothelial cells, tumor vessels [more]

Chemotherapy-induced nanovaccines implement immunogenicity equivalence for improving cancer chemoimmunotherapy

R Li, Y Hao, K Roche, G Chen, W Pan, AZ Wang, Y Min

Biomaterials (Elsevier) China, USA, 21 August 2023

Oncology, Pharmacology

Key words: Chemoimmunotherapy, Nanovaccines, Neoantigens, Damage associated molecular patterns, Anti-PD-1 [more]

Integrative Evaluation of the Clinical Significance Underlying Protein Arginine Methyltransferases in Hepatocellular Carcinoma

Y Jiang, S Wei, JM Koo, HJ Kim, W Park, Y Zhang, H Guo, KT Ha, CM Oh, JS Kang, JH Jeong, D Ryu, KJ Kim, Y Jo

Cancers (MDPI) China, South Korea, 20 August 2023

Oncology

Key words: protein arginine methyltransferase, protein methylation, hepatocellular carcinoma, T cell exhaustion, tissue microarray, prognostic marker [more]

Cellular Membrane-Engineered Nanovesicles as a Three-Stage Booster to Target the Lesion Core

F Huang, Y Du, Y Chen, Z Qiu, Z Wang, Y Fan, Y Shi, Z Li, K Yang, W Cui, W Jin

Advanced Materials (Wiley) China, 17 August 2023

Pharmacology, Nanomedicine

High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach

CM Hsu, KC Chang, TM Chuang, ML Chu, PW Lin, HS Liu, SY Kao, YC Liu, CT Huang, MH Wang, TJ Yeh, YC Gau, JS Du, HC Wang, SF Cho, CE Hsiao, Y Tsai, SY Hsiao, LC Hung, CH Yen, HH Hsiao

Cancers (MDPI) Taiwan, USA, 17 August 2023

Oncology, Pharmacology

Key words: DLBCL, G9a/EHMT2, niclosamide, autophagy, immunohistochemistry, TissueFAXS PLUS, HistoQuest [more]

Alveolar Ridge Augmentation with a Novel Combination of 3D-Printed Scaffolds and Adipose-Derived Mesenchymal Stem Cells—A Pilot Study in Pigs

CS Lau, J Chua, S Prasadh, J Lim, L Saigo, BT Goh

Biomedicines (MDPI) Singapore, USA, 16 August 2023

Tissue Engineering

Key words: alveolar ridge augmentation, 3D-printed scaffolds, adipose-derived mesenchymal stem cells, tissue engineering, pig model [more]

An Engineered Adeno-Associated Virus Capsid Mediates Efficient Transduction of Pericytes and Smooth Muscle Cells of the Brain Vasculature

SH Ramirez, JF Hale, S McCarthy, CL Cardenas, KN Udeni Galpayage Dona, KS Hanlon, E Hudry, D De La Cruz, C Ng, S Das, DM Nguyen, J Nammour, RE Bennett, AM Andrews, PL Musolino, CA Maguire

Human Gene Therapy (Mary Ann) USA, 16 August 2023

Neuroscience, Pharmacology

Key words: adeno-associated virus vector, pericytes, smooth muscle cells [more]

The putative protein kinase Stk36 is essential for ciliogenesis and CSF flow by associating with Ulk4

H Zhang, M Yang, J Zhang, L Li, T Guan, J Liu, X Gong, F Yang, S Shen, M Liu, Y Han

The FASEB Journal (Wiley) China, Ireland, 16 August 2023

Neuroscience

Key words: ependymal cells, hydrocephalus, motile cilia, Stk36, Ulk4, ventriculomegaly [more]

Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response

S Tan, Z Wang, N Li, X Guo, Y Zhang, H Ma, X Peng, Y Zhao, C Li, L Gao, T Li, X Lian, C Ma

Cell Death & Differentiation (Nature) China, 15 August 2023

Oncology, Immunology

Key words: Cancer microenvironment, Inflammation [more]

Obstruction of the Tear Drainage Altered Lacrimal Gland Structure and Function

B Xiao, D Guo, R Liu, M Tu, Z Chen, Y Zheng, C Liu, L Liang

Investigative Opthalmology & Visual Science (iovs.arvojournals.org) China, 12 August 2023

Ophthalmology

[more]

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

J Pencik, C Philippe, M Schlederer, E Atas, M Pecoraro, S Grund-Gröschke, WJ Li, A Tracz, I Heidegger, S Lagger, K Trachtová, M Oberhuber, E Heitzer, O Aksoy, HA Neubauer, B Wingelhofer, A Orlova, N Witzeneder, T Dillinger, E Redl, G Greiner, D D’Andrea, JR Östman, S Tangermann, I Hermanova, G Schäfer, F Sternberg, EE Pohl, C Sternberg, A Varady, J Horvath, D Stoiber, TI Malcolm, SD Turner, EE Parkes, B Hantusch, G Egger, S Rose-John, V Poli, S Jain, CWD Armstrong, G Hoermann, V Goffin, F Aberger, R Moriggl, A Carracedo, C McKinney, RD Kennedy, H Klocker, MR Speicher, DG Tang, AA Moazzami, DM Heery, M Hacker, L Kenner

Molecular Brain (BMC) Austria, USA, Switzerland, Czech Republic, Sweden, Spain, UK, Italy, France, 12 August 2023

Oncology

Key words: STAT3, mTORC1, AR, Prostate Cancer, LKB1, AMPK, CREB, Metformin [more]

Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery

K Wuputra, MH Tsai, K Kato, CC Ku, JB Pan, YH Yang, S Saito, CC Wu, YC Lin, KH Cheng, KK Kuo, M Noguchi, Y Nakamura, T Yoshioka, DC Wu, CSn Lin, KK Yokoyama

Inflammation and Regeneration (BMC) Taiwan, Japan, 11 August 2023

Cell Biology

Key words: Antioxidation, Aryl hydrocarbon receptor, Dioxin responsive element, Nuclear factor (erythroid-derived 2)-like 2 transcription factor, Jun dimerization protein 2, Oxidative stress, Reactive oxygen species, Transcriptional regulation

FK506-Binding Protein Like (FKBPL) Regulates Hypoxia-induced Factor-α and Restores Endothelial Function and Vascular Integrity in Ischaemia-induced Angiogenesis

L McClements, S Ghorbanpour, S Cartland, S Seth, R Ecker, C Richards, K McGrath, L Cole, M Warkiani, M Kavurma

Heart, Lung and Circulation (Elsevier) Australia, Austria, 10 August 2023

Cardiology

Case report: genetic and immune microenvironmental characteristics of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis who achieved complete remission after treatment with PD-1 inhibitor

Y Song, J Long, X Su, Z Chen, Y He, W Shao, B Wang, C Chen

Frontiers in Immunology (Frontiers Media S.A.) China, 09 August 2023

Oncology, Pharmacology

Key words: MSS, rectal cancer, hepatopulmonary metastasis, immunotherapy, tumor immune microenvironment [more]

Compartmentalized Nano-MOFs as Co-delivery Systems for Enhanced Antitumor Therapy

W Duan, L Hang, Y Ma, Q Wang, X Tang, W Jiang, Y Wu, W Lv, Y Wang

ACS Applied Materials & Interfaces (ACS Publications) China, 08 August 2023

Oncology, Pharmacology

Key words: bioactive macromolecules compartmentalized structures nano-metal-organic frameworks co-delivery cancer therapy [more]

Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity

A Serrano‐Benitez, SE Wells, L Drummond-Clarke, LC Russo, JC Thomas, GA Leal, M Farrow, JM Edgerton, S Balasubramanian, M Yang, C Frezza, A Gautam, J Brazina, K Burdova, NC Hoch, SP Jackson, KW Caldecott

The EMBO Journal (EMBO Press) UK, Brazil, Germany, 07 August 2023

Cell Biology

Key words: bioactive macromolecules, compartmentalized structures, nano-metal-organic frameworks, co-delivery, cancer therapy [more]

Bj-PRO-10c, as an allosteric regulator of argininosuccinate synthase, is a potential therapy for neuroblastoma metastasis

F Coutinho, LMF Guimarães, R Seeger, APJ Santos, T Glaser, D Yamamoto, L Lacerda, V Arnaud-Sampaio, CVT Rossini, I Rabelo, NM de Medeiros, D Ramos Truzzi, M Aparecida Juliano, L Juliano, H Ulrich, C Lameu

Toxicon (Elsevier) Brazil, 06 August 2023

Oncology, Pharmacology

Key words: Metastasis, Nitric oxide, Proline-rich peptide, Neuroblastoma, Tumor progression [more]

Unveiling nature's potential weapon: Magnolol's role in combating bladder cancer by upregulating the miR-124 and inactivating PKC-δ/ERK axis

FT Hsu, WL Liu, SR Lee, LB Jeng, JH Chen

Phytomedicine (Elsevier) Taiwan, 05 August 2023

Oncology, Pharmacology

Key words: Bladder cancer, ERK, Magnolol, miR-124-3p, NF-κB, PKCδ [more]

Aberrant expression of IL-17A in mast cells contributes to the pathogenesis of hidradenitis suppurativa

CB Chu, CC Yang, YY Hsueh, PC Chen, YK Hong, YY Kuo, SJ Tsai

British Journal of Dermatology (Oxford Academic) Taiwan, 04 August 2023

Dermatology

[more]

The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity

X Sun, L He, H Liu, RF Thorne, T Zeng, L Liu, B Zhang, M He, Y Huang, M Li, E Gao, M Ma, C Cheng, F Meng, C Lang, H Li, W Xiong, S Pan, D Ren, B Dang, Y Yang, M Wu, L Liu

Cell Metabolism (Cell Press) China, 04 August 2023

Oncology

Key words: diapause-like state, chemotherapy insensitivity, colorectal cancer, histone lactylation, polyploidy, glycolysis, SMC4 [more]

Evaluation of the prognostic and therapeutic potential of inhibin beta B for oral squamous cell carcinoma

YY Chung, SJ Cheng, HH Ko, WY Shie, HYE Chou

Journal of Dental Science (Elsevier) Taiwan, 04 August 2023

Oncology

Key words: INHBB, Menin, Oral squamous cell carcinoma, Prognostic factor [more]

Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2‐dependent mechanism

WJ Ni, H Zhou, H Lu, NN Ma, BB Hou, W Li, FX Kong, JT Yu, R Hou, J Jin, JG Wen, T Zhang, XM Meng

Clinical and Translational Medicine (Wiley) China, 03 August 2023

Nephrology

Key words: chronic kidney disease, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2),methyltransferase-like 3 (METTL3),N6-methyladenosine (m6A), renal fibrosis, traditional Chinese medicine [more]

Single-cell landscape of immune cells in human livers affected by HBV-related cirrhosis

Q Bai, X Hong, H Lin, X He, R Li, M Hassan, H Berger, F Tacke, C Engelmann, T Hu

JHEP Reports (Elsevier) China, Germany, UK, 03 August 2023

Immunology, Hepathology

Key words: Hepatitis B, Cirrhosis, Liver, Single-cell RNAseq, Immune cell [more]

Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis

CX Lim, A Redl, L Kleissl, RV Pandey, C Mayerhofer, T El Jammal, M Mazic, K Gonzales, N Sukhbaatar, T Krausgruber, C Bock, M Hengstschlager, A Calender, Y Pacheco, G Stary, T Weichhart

American Journal of Respiratory and Critical Care Medicine (ATS Journals) Austria, France, 01 August 2023

Immunology, Endocrinology

Key words: directed evolution, estrogen receptor, nuclear receptors, Saccharomyces cerevisiae, synthetic biology, tamoxifen

Selection, identification and crystal structure of shark-derived single-domain antibodies against a green fluorescent protein

YL Chen, XX Xie, P Zheng, C Zhu, H Ma, Z Khalid, YJ Xie, YZ Dang, Y Ye, N Sheng, N Zhong, WH Lei, C Zhang, LJ Zhang, T Jin, MJ Cao

International Journal of Biological Macromolecules (Elsevier) China, 01 August 2023

Microscopy

Key words: Chiloscyllium plagiosum, Green fluorescent protein, Variable domain of new antigen receptors, Phage display, Crystal structure, Immunostaining [more]

Maternal di-(2-ethylhexyl) phthalate exposure elicits offspring IFN-λ upregulation: Insights from birth cohort, murine model, and in vitro mechanistic analysis

FC Kuo, ML Tsai, ST Wu, SS Li, CF Wu, SL Wang, MWY Chan, JL Suen, MT Wu, CH Hung

Food and Chemical Toxicology (Elsevier) Taiwan, 31 July 2023

Toxicology

Key words: IFNλ, di-(2-ethylhexyl) phthalate, Bronchial epithelium, Dendritic cell, PPARs, Histone modification

Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents

M Xia, BN Agca, T Yoshida, J Choi, U Amjad, K Bose, N Keren, S Zukerman, MJ Cima, AM Graybiel, HN Schwerdt

Biosensors and Bioelectronics (Elsevier) USA, 30 July 2023

Neuroscience

Key words: Neural interface, Microelectrode array, Neurochemical probes, Dopamine sensors, Fast scan cyclic voltammetry, Striatum, Parkinson’s disease, Carbon fiber electrodes [more]

Farnesoid X receptor activation inhibits pancreatic carcinogenesis

Z Xu, Z Huang, Y Zhang, H Sun, U Hinz, U Heger, M Loos, FJ Gonzalez, T Hackert, F Bergmann, F Fortunato

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Germany, USA, 27 July 2023

Oncology

Key words: Pancreatic ductal adenocarcinoma, Pancreatic carcinogenesis, Farnesoid X receptor, Bile acid [more]

The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis

L Shmuel-Galia, F Humphries, T Vierbuchen, Z Jiang, N Santos, J Johnson, B Shklyar, L Joannas, N Mustone, S Sherman, D Ward, J Houghton, CE Baer, A O'Hara, J Henao-Mejia, K Hoebe, KA Fitzgerald

Cell Metabolism (Cell Press) USA, Israel, 25 July 2023

Gastroenterology

Key words: intestinal inflammation, colitis, IBD, mucosal inflammation, lncRNA, ncRNA, mitochondria, Krebs cycle, OXPHOS, complex I, mtROS [more]

Choice of Polymer, but Not Mesh Structure Variation, Reduces the Risk of Bacterial Infection with Staphylococcus aureus In Vivo

SM Schmitz, MJ Helmedag, A Kroh, D Heise, U Klinge, A Lambertz, MW Hornef, UP Neumann, RM Eickhoff

Biomedicines (MDPI) Germany, 24 July 2023

Tissue Engineering

Key words: mesh infection, hernia, foreign body reaction, mesh material, mesh structure [more]

B7-H3 confers stemness characteristics to gastric cancer cells by promoting glutathione metabolism through AKT/pAKT/Nrf2 pathway

L Xia, Y Chen, J Li, J Wang, K Shen, A Zhao, H Jin, G Zhang, Q Xi, S Xia, T Shi, R Li

Chinese Medical Journal (mednexus.org) China, 24 July 2023

Oncology

[more]

TRAF3/STAT6 axis regulates macrophage polarization and tumor progression

JH Shi, LN Liu, DD Song, WW Liu, C Ling, FX Wu, TT Wang, B Liu, NP Cui, ZY Ni

Cell Death & Differentiation (Nature) China, 21 July 2023

Oncology

Key words: Cancer microenvironment, Signal transduction, Ubiquitylation [more]

Microenvironmental and cell intrinsic factors governing human cDC2 differentiation and monocyte reprogramming

M Lang, C Krump, A Meshcheryakova, C Tam-Amersdorfer, E Schwarzenberger, C Passegger, S Connolly, D Mechtcheriakova, H Strobl

Frontiers in Immunology (Frontiers Media S.A.) Austria, 19 July 2023

Immunology

Key words: dendritic cell, Langerhans cell, transcriptional reprogramming, lineage decision, epidermal signaling, inflammatory skin disease [more]

Human intestine and placenta exhibit tissue-specific expression of RAGE isoforms

K Schwertner, K Gelles, J Leitner, P Steinberger, C Gundacker, R Vrticka, K Hoffmann-Sommergruber, I Ellinger, S Geiselhart

Heliyon (Cell Press) Austria, 18 July 2023

Reproductive Medicine

Key words: RAGE, Innate immune receptor, Alternative splicing, Small intestine, Colon, Placenta, Antibody validation [more]

Aged-Signal-Eliciting Nanoparticles Stimulated Macrophage-Mediated Programmed Removal of Inflammatory Neutrophils

K Chen, Z Zhang, Z Fang, J Zhang, Q Liu, W Dong, Y Liu, Y Wang, J Wang

ACS Nano (ACS Publications) China, 17 July 2023

Nanomedicine

Key words: Biomimetic nanoparticles programmed cell removal aged signal activated neutrophils inflammation treatment [more]

Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter

R Zhang, S Chen, Z Wang, L Ye, Y Jiang, M Li, X Jiang, H Peng, Z Guo, L Chen, R Zhang, Y Niu, M Ashner, D Li, W Chen

Environmental Health Perspectives (EHP) China, USA, 17 July 2023

Pulmonology

[more]

FOXM1 is critical for the fitness recovery of chromosomally unstable cells

F Pan, S Chocarro, M Ramos, Y Chen, AA de la Vega, K Somogyi, R Sotillo

Cell Death & Disease (Nature) Germany, 14 July 2023

Oncology

Key words: Cancer, Cell biology [more]

S100A5 Attenuates Efficiency of Anti‐PD‐L1/PD‐1 Immunotherapy by Inhibiting CD8+ T Cell‐Mediated Anti‐Cancer Immunity in Bladder Carcinoma

H Li, J Chen, Z Li, M Chen, Z Ou, M Mo, R Wang, S Tong, P Liu, Z Cai, C Zhang, Z Liu, D Deng, J Liu, C Cheng, J Hu, X Zu

Advanced Science (Wiley) China, 06 July 2023

Oncology, Immunology

[more]

A risk prognostic model for patients with esophageal squamous cell carcinoma basing on cuproptosis and ferroptosis

J Li, J Liu, J Li, A Feng, Y Nie, Z Yang, W Zhang

Journal of Cancer Research and Clinical Oncology (Springer) China, 05 July 2023

Oncology

Key words: Ferroptosis, Cuproptosis, Esophageal cancer, Clinicopathologic features, Tumor immune microenvironment [more]

Late Effects of Chronic Low Dose Rate Total Body Irradiation on the Heart Proteome of ApoE−/− Mice Resemble Premature Cardiac Ageing

O Azimzadeh, J Merl-Pham, V Subramanian, K Oleksenko, F Krumm, M Mancuso, E Pasquali, IB Tanaka III, S Tanaka, MJ Atkinson, S Tapio, S Moerti

Cancers (MDPI) Germany, USA, Italy, Japan, Germany, 29 June 2023

Cardiology

Key words: ionising radiation, TBI, chronic exposure, cardiovascular disease, ageing, proteomics, PPARα, TGFβ, SIRT, AMPK, heart, oxidative stress [more]

Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2

FJ Cheng, CY Ho, TS Li, Y Chen, YL Yeh, YL Wei, TK Huynh, BR Chen, HY Ko, CS Hsueh, M Tan, YC Wu, HC Huang, CH Tang, CH Chen, CY Tu, WC Huang

Cell & Bioscience (Springer) Taiwan, 28 June 2023

Pharmacology, SARS-CoV-2

Key words: Artemisia argyi, Eriodictyol, Umbelliferone, TMPRSS2, ACE2, SARS-CoV-2 variants [more]

Prognostic and immune infiltration significance of ARID1A in TCGA molecular subtypes of gastric adenocarcinoma

Z Zhang, Q Li, S Sun, J Ye, Z Li, Z Cui, Q Liu, Y Zhang, S Xiong, S Zhang

Cancer Medicine (Wiley) China, Japan, 27 June 2023

Oncology

Key words: ARID1A, gastric adenocarcinoma, immune infiltration, prognosis, TCGA subtype [more]

Extrafollicular IgD-CD27-CXCR5-CD11c-DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19

H Allard-Chamard, N Kaneko, A Bertocchi, N Sun, J Boucau, HH Kuo, JR Farmer, C Perugino, VS Mahajan, SJH Murphy, K Premo, T Diefenbach, M Ghebremichael, G Yuen, A Kotta, Z Akman, M Lichterfeld, BD Walker, XG Yu, M Moriyama, S Pillai

Cell Reports (Cell Press) USA, Canada, Japan, 27 June 2023

Immunology, SARS-CoV-2

Key words: double-negative B cells, DN3 B cells, extrafollicular B cells, COVID-19 pathogenesis, IgG4-related disease, inflammatory fibrosis, B cell depletion in disease, T-B collaboration in disease [more]

Mesenchymal progenitor cells from non-inflamed versus inflamed synovium post-ACL injury present with distinct phenotypes and cartilage regeneration capacity

RJ Krawetz, L Larijani, JM Corpuz, N Ninkovic, N Das, A Olsen, N Mohtadi, A Rezansoff, A Dufour

Stem Cell Research & Therapy (BMC) Canada, 25 June 2023

Stem Cell Research

Key words: Mesenchymal progenitor cells, Osteoarthritis, Inflammation, ACL injury [more]

An integrative analysis of lipidomics and transcriptomics in various mouse brain regions in response to real-ambient PM2. 5 exposure

S Qin, H Zeng, Q Wu, Q Li, M Zeeshan, L Ye, Y Jiang, M Li, R Zhang, W Chen, WC Chou, GH Dong, DC Li, XW Zeng

Science of The Total Environment (Elsevier) China, USA, 24 June 2023

Neuroscience

Key words: Fine particulate matter, Neurotoxicity, Multi-omics, Brain regions, Bile acid biosynthesis [more]

Crosstalk between myeloid and B cells shapes the distinct microenvironments of primary and secondary liver cancer

Z Chen, G Zhang, X Ren, Z Yao, Q Zhou, X Ren, S Chen, L Xu, K Sun, Q Zeng, M Kuang, DM Kuang, S Peng

Cancer Research (AACR) China, 23 June 2023

Oncology

Key words: Tumor-infiltrating B cells, Tumor microenvironment, Liver cancer [more]

A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells

A Cheng, T Xu, W You, T Wang, D Zhang, H Guo, H Zhang, X Pan, Y Wang, L Liu, K Zhang, J Shi, X Yao, J Guo, Z Yang

Nature Metabolism (Nature) China, 22 June 2023

Oncology

Key words: Cancer, Cancer metabolism, Metabolism, Mitosis [more]

Chemokine receptor CXCR7 activates AURKA and promotes neuroendocrine prostate cancer growth

G Gritsina, K Fong, X Lu, Z Lin, W Xie, S Agarwal, D Lin, GE Schiltz, H Beltran, E Corey, C Morrissey, Y Wang, JC Zhao, M Hussain, J Yu

The Journal of Clinical Investigation (Am Soc Clin Investig) USA, China, Canada, 22 June 2023

Oncology

[more]

Analysis of Aldehyde Dehydrogenase 2 as a Prognostic Marker Associated with Immune Cell infiltration and Chemotherapy Efficacy in Head and Neck Squamous Cell Carcinoma

YH Lin, YF Yang, JB Liao, TS Chang, UGS Janesha, YL Shiue

Journal of Cancer (Ivyspring International Publisher) Taiwan, 19 June 2023

Oncology, Pharmacology

Key words: Aldehyde Dehydrogenase 2, head and neck squamous cell carcinoma, human papillomavirus, tumor microenvironment, 5-fluorouracil [more]

Successful targeting in situ of an oncogenic nuclear antigen by hapten induced tumor associated autoantibodies (iTAA)

B Yu, J Zhang, Q Fu, Y Han, J Zhang, F Gao, P Jing, P Zhang, G Zheng

Scientific Reports (Nature) China, 19 June 2023

Oncology, Pharmacology

Key words: Biological techniques, Cancer, Chemical biology, Drug discovery, Immunology, Neuroscience [more]

AlF-NOTA-FAPI-04 PET/CT can predict treatment response and survival in patients receiving chemotherapy for inoperable pancreatic ductal adenocarcinoma

Z Zhu, K Cheng, Z Yun, X Zhang, X Hu, J Liu, F Wang, Z Fu, J Yue

European Journal of Nuclear Medicine and Molecular Imaging (Springer) China, 17 June 2023

Oncology

Key words: Fibroblast activation protein, Pancreatic adenocarcinoma, Metabolic tumor volume, Total lesion FAP expression [more]

TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway

W Wu, J Xu, D Gao, Z Xie, W Chen, W Li, Q Yuan, L Duan, Y Zhang, X Yang, Y Chen, Z Dong, K Liu, Y Jiang

Cell Death & Disease (Nature) China, 16 June 2023

Oncology

Key words: Immunochemistry, Oncogenes [more]

Probiotic lactic acid bacteria alleviate pediatric IBD and remodel gut microbiota by modulating macrophage polarization and suppressing epithelial apoptosis

H Hua, C Pan, X Chen, M Jing, J Xie, Y Gao, J Huang, X Chen, Y Gao, C Xu, P Li

Frontiers in Microbiology (Frontiers Media S.A.) China, 15 June 2023

Microbiology

Key words: pediatric IBD, macrophage polarization, intestinal epithelium apoptosis, Akkermansia muciniphila, Pediococcus pentosaceus CECT8330 [more]

Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration

W Xu, X Liu, W Han, K Wu, M Zhao, T Mei, B Shang, J Wu, J Luo, Y Lai, B Yang, Y Zhuo, L Lu, Y Liu, XL Tian, L Zhao

Cell Communication and Signaling (BMC) China, 14 June 2023

Ophthalmology

Key words: HTRA1, Hypoxia, HIF1α, Retinal pigment epithelium, Cell senescence, Age-related macular degeneration [more]

SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy

JBM Kamarudin, B Sun, ASC Foo, XY Lim, H Judd, X Tan, XH Tan, RB Razar, M Liu, J Zhong, JJ Chua, CWQ Ng, JCH Goh, TZ Tan, BH Parikh, X Su, AP Kumar, WY Ong, N Yamaguchi, SY Set, GW Yip, Y Zhang, DBL The

ACS Nano (ACS Publications) Singapore, Japan, 12 June 2023

Oncology, Pharmacology

Key words: Photodynamic therapy near-infrared upconversion nanoparticle implant breast cancer 5-aminolevulinic acid [more]

Cyclophilin D as a potential therapeutic target of liver ischemia/reperfusion injury by mediating crosstalk between apoptosis and autophagy

M Yang, Z Wang, J Xie, M Reyad-ul-Ferdous, S Li, Y Song

Chronic Diseases and Translational Medicine (Wiley) China, 11 June 2023

Pharmacology, Hepathology

Key words: apoptosis, autophagy, cyclophilin D, ischemia/reperfusion, necrosis, reactive oxygen species [more]

Exogenously delivered iPSCs disrupt the natural repair response of endogenous MPCs after bone injury

L Ferrie, P Premnath, A Olsen, L Larijani, BA Besler, DE Rancourt, NA Duncan, TM Underhill, RJ Krawetz

Scientific Reports (Nature) Canada, 09 June 2023

Osteology

Key words: Bone, Musculoskeletal system, Osteoporosis, Pluripotent stem cells [more]

RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer

S Zhang, J Wang, W Hu, L He, Q Tang, J Li, M Jie, X Li, C Liu, Q Ouyang, S Yang, C Hu

JCI insight (The American Society for Clinical Investigation) China, 08 June 2023

Gastroenterology, Oncology

Key words: Cancer gene therapy, Gastric cancer, Oncogenes [more]

Topical ozone accelerates diabetic wound healing by promoting re-epithelialization via activation of IGF1R-EGFR signaling

JY Lu, XQ Wang, ZB Fu, LH Gao, H Mannam, YP Xiang, YY Joo, JR Zeng, D Wang, AS Paller

Journal of Investigative Dermatology (Elsevier) China, USA, 08 June 2023

Dermatology

Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

X Wu, EAB Azizan, E Goodchild, S Garg, M Hagiyama, CP Cabrera, FL Fernandes-Rosa, S Boulkroun, JL Kuan, Z Tiang, A David, M Murakami, CA Mein, E Wozniak, W Zhao, A Marker, F Buss, RS Saleeb, J Salsbury, Y Tezuka, F Satoh, K Oki, AM Udager, DL Cohen, H Wachtel, PJ King, WM Drake, M Gurnell, J Ceral, A Ryska, M Mustangin, YP Wong, GC Tan, M Solar, M Reincke, WE Rainey, RS Foo, Y Takaoka, SA Murray, MC Zennaro, F Beuschlein, A Ito, MJ Brown

Nature Genetics (Nature) UK, Malaysia, Japan, France, Singapore, Germany, USA, Czech Republic, Switzerland, 08 June 2023

Cardiology

Key words: Genetics research, Translational research [more]

Integrated Transcriptome and Metabolome Dynamic Analysis of Galls Induced by the Gall Mite Aceria pallida on Lycium barbarum Reveals the Molecular Mechanism Underlying Gall Formation and Development

M Yang, H Li, H Qiao, K Guo, R Xu, H Wei, J Wei, S Liu, C Xu

International Journal of Molecular Sciences (MDPI) China, 07 June 2023

Agricultural Science

Key words: plant gall, gall mite, mite–plant interaction, gall development, molecular mechanism, transcriptome, metabolome, phytohormones [more]

The role of pores in micro-zone distribution of Cd in a tropical paddy soil: Results from X-ray computed tomography combined energy dispersive spectroscopy analysis

C Wei, B Lin, B Liu, Z He, Q Li

Journal of Hazardous Materials (Elsevier) China, USA, 07 June 2023

Ecology

Key words: Cadmium, Undisturbed tropical soil, Micro-zone distribution, Air space pores, Water-holding pores [more]

Laser ablation-inductively coupled plasma-mass spectrometry analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma

A Tisza, T Klikovits, M Benej, S Torok, B Szeitz, Z Valko, MA Hoda, B Hegedus, M Bonta, W Nischkauer, K Hoetzenecker, A Limbeck, K Schelch, V Laszlo, Z Megyesfalvi, B Dome

British Journal of Clinical Pharmacology (Wiley) Hungary, Austria, Germany, Sweden, 05 June 2023

Oncology, Pharmacology

Key words: intratumoural drug distribution, laser ablation-inductively coupled plasma-mass spectrometry,mass spectrometry imaging, neoadjuvant chemotherapy, platinum, pleural mesothelioma [more]

Fluoxetine inactivates STAT3/NF-κB signaling and promotes sensitivity to cisplatin in bladder cancer

CJ Yang, ZL Tan, JD Yang, FT Hsu, CH Chiang

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 03 June 2023

Oncology

Key words: Muscles invasive bladder cancer, Fluoxetine, STAT3, NF-κB, Apoptosis [more]

Axonal mapping of the motor cranial nerves

V Tereshenko, U Maierhofer, DC Dotzauer, G Laengle, O Politikou, G Carrero Rojas, C Festin, M Luft, FJ Jaklin, LA Hruby, A Gohritz, D Farina, R Blumer, KD Bergmeister, OC Aszmann

Frontiers in Neuroanatomy (Frontiers Media S.A.) Austria, USA, Switzerland, UK, 02 June 2023

Neuroscience

Key words: facial nerve, hypoglossal nerve, masseteric nerve, facial muscles, sensory feedback, sympathetic axons, motor control, proprioception [more]

Lineage-specific accelerated sequences underlying primate evolution

X Bi, L Zhou, JJ Zhang, S Feng, M Hu, DN Cooper, J Lin, J Li, DD Wu, G Zhang

Science Advances (Science) China, UK, 01 June 2023

Evolution

[more]

E7050 Suppresses the Growth of Multidrug-Resistant Human Uterine Sarcoma by Inhibiting Angiogenesis via Targeting of VEGFR2-Mediated Signaling Pathways

TT Huang, CM Chen, SS Lin, YW Lan, HC Cheng, KB Choo, CC Wang, TH Huang, KY Chong

International Journal of Molecular Sciences (MDPI) Taiwan, USA, Malaysia, 31 May 2023

Oncology

Key words: E7050, VEGFR2, VEGF, multidrug-resistant human uterine sarcoma, angiogenesis [more]

Gastroprotective effects of Machilus zuihoensis Hayata against acidic ethanol-induced gastric ulcer in mice

SC Huang, WJ Wu, YJ Lee, MS Tsai, XZ Yan, HC Lin, PY Lai, KT Wang, JW Liao, JC Tsai

Journal of Traditional and Complementary Medicine (Elsevier) Taiwan, 31 May 2023

Gastroenterology

Key words: Gastroprotection, Mucus secretion, Antioxidation, Anti-inflammation, MAPK and NF-κB signaling pathways [more]

NQO1/CPT1A promotes the progression of pancreatic adenocarcinoma via fatty acid oxidation: NQO1/CPT1A promotes PAAD via FAO

R Xu, Y Liu, L Ma, Y Sun, H Liu, Y Yang, T Jin, D Yang

Acta Biochimica et Biophysica Sinica (Oxford University Press) China, 29 May 2023

Oncology, Endocrinology

Key words: NQO1, PAAD, metastasis, fatty acid oxidation, CPT1A [more]

Inhibition of CDK9 exhibits anticancer activity in hepatocellular carcinoma cells via targeting ribonucleotide reductase

JC Lin, TP Liu, YB Chen, TS Huang, TY Chen, PM Yang

Toxicology and Applied Pharmacology (Elsevier) Taiwan, 27 May 2023

Oncology, Pharmacology

Key words: Cyclin-dependent kinase 9, Hepatocellular carcinoma, Protein degradation, Ribonucleotide reductase [more]

Emodin, a Natural Anthraquinone, Increases Uric Acid Excretion in Rats with Potassium Oxonate-Induced Hyperuricemia

SW Hou, SJ Chen, JD Shen, HY Chen, SJ Wang, CH Wang, KM Man, PL Liu, MY Tsai, YH Chen, WC Chen

Pharmaceuticals (MDPI) Taiwan, 25 May 2023

Toxicology

Key words: uric acid, gout, emodin, potassium oxonate, traditional Chinese medicine, rats [more]

Characterization of genetic humanized mice with transgenic HLA DP401 or DRA but deficient in endogenous murine MHC class II genes upon Staphylococcus aureus pneumonia

F Li, B Niu, L Liu, M Zhu, H Yang, B Qin, X Peng, L Chen, C Xu, X Zhou

Animal Models and Experimental Medicine (Wiley) China, 23 May 2023

Pathology

[more]

Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats

Y Huang, W Sun, F Gao, H Ma, T Yuan, Z Liu, H Liu, J Hu, J Bai, X Zhang, R Wang

Biology (MDPI) China, 23 May 2023

Neuroscience, Aging

Key words: aromatase, brain-derived estrogen, neurogenesis, gliogenesis, aging [more]

M2e‐specific antibodies protect against influenza PR8 virus in an isotype and route dependent manner

T Sun, Y Wang, P Zou, Q Wang, J Liu, W Liu, J Huang, F Wu

Journal of Medical Virology (Wiley) China, 23 May 2023

Immunology, Virology

Key words: Antibody, influenza A virus, isotype, M2e, protection [more]

Enhancing de novo ceramide synthesis induced by bisphenol A exposure aggravates metabolic derangement during obesity

G Wang, X Hong, J Yu, Y Zhang, Y Li, Z Li, Z Zhu, S Yuan, X Zhang, S Wang, F Zhu, Y Wang, C Wu, P Su, T Shen

Molecular Metabolism (Elsevier) China, UK, 22 May 2023

Endocrinology

Key words: Bisphenol A, ceramide, adipose tissue inflammation, insulin resistance, myriocin [more]

Identification of cervical cancer stem cells using single-cell transcriptomes of normal cervix, cervical premalignant lesions, and cervical cancer

T Zhang, L Zhuang, M Muaibati, D Wang, A Abasi, Q Tong, D Ma, L Jin, X Huang

eBioMedicine (Elsevier) China, 22 May 2023

Stem Cell Research, Oncology

Key words: Cervical cancer, Single-cell RNA sequencing, HSIL, Microinvasive carcinoma of the cervix, Cancer stem cell, Tumor microenvironment [more]

The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage

X Zhu, W Liu, X Tang, Y Chen, X Ge, Q Ke, X Liang, Y Gan, Y Zheng, M Zou, M Deng, Y Liu, DWC Li, L Gong

Journal of Neuroinflammation (Springer) China, 22 May 2023

Ophthalmology

Key words: Retinal degeneration, BET, Neuroinflammation, PROTAC, cGAS-STING, Microglia/macrophage [more]

APP/PS1 Gene-Environmental Cadmium Interaction Aggravates the Progression of Alzheimer's Disease in Mice via the Blood-Brain Barrier, Amyloid-β, and Inflammation

J Liu, Y Xie, Y Lu, Z Zhao, Z Zhuang, L Yang,, H Huang, H Li, Z Mao, S Pi, F Chen, Y He

Journal of Alzheimer's Disease (IOS Press) China, 20 May 2023

Neuroscience

Key words: Alzheimer’s disease, APP/PS1 gene, blood-brain barrier, cadmium, gene-environment interaction, inflammatory response

Increased number and domain of interlaminar astrocytes in layer I of the temporal cortex in epilepsy

N Zhou, Z Fan, Y Tong, X Xiao, Y Xie, Z Qi, L Chen

Neuropathology and Applied Neurobiology (Wiley) China, 20 May 2023

Neuroscience

Key words: Interlaminar astrocytes, Chaslin’s gliosis, Astrocyte domain, Temporal cortex, Epilepsy [more]

NLRP3‐Dependent Crosstalk between Pyroptotic Macrophage and Senescent Cell Orchestrates Trauma‐Induced Heterotopic Ossification During Aberrant Wound Healing

J Li, X Wang, Z Yao, F Yuan, H Liu, Z Sun, Z Yuan, G Luo, X Yao, H Cui, B Tu, Z Sun, C Fan

Advanced Science (Wiley) China, 19 May 2023

Osteology

[more]

Targeting CD44 variant 5 with an antibody-drug conjugate is an effective therapeutic strategy for intrahepatic cholangiocarcinoma

Y Bei, J He, X Dong, Y Wang, S Wang, W Guo, C Cai, Z Xu, J Wei, B Liu, N Zhang, P Shen

Cancer Research (AACR) China, Ireland, 19 May 2023

Pharmacology, Oncology

Key words: intrahepatic cholangiocarcinoma, CD44 variant 5, antibody-drug conjugate, PDX [more]

Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression-and anxiety-like behavior in mice

R Wang, ZH Liu, N Bi, X Gu, C Huang, R Zhou, H Liu, HL Wang

Ecotoxicology and Environmental Safety (Elsevier) China, 19 May 2023

Neuroscience, Toxicology

Key words: Bisphenol A (BPA), Depression- and anxiety-like behavior, Microglial activation, Neuroinflammation, Medial prefrontal cortex (mPFC) [more]

Cytolytic CD8+ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes

DR Collins, J Hitschfel, JM Urbach, GH Mylvaganam, NL Ly, U Arshad, ZJ Racenet, AG Yanez, TJ Diefenbach, BD Walker

Science Immunology (Science) USA, Germany, 19 May 2023

Immunology, Virology

[more]

Following nanoparticle uptake by cells using high-throughput microscopy and the deep-learning based cell identification algorithm Cellpose

B Yang, CJ Richards, TB Gandek, I de Boer, IA Zuazo, E Niemeijer, C Aberg

Frontiers in Nanotechnology (Frontiers Media S.A.) , 18 May 2023

Nanomedicine, Medical Image Analysis

Key words: nanoparticles, cell uptake, fluorescence microscopy, high-throughput, machine learning, image segmentation, modelling, Cellpose [more]

Peptide-Functionalized and Drug-Loaded Tomato Bushy Stunt Virus Nanoparticles Counteract Tumor Growth in a Mouse Model of Shh-Dependent Medulloblastoma

L Marchetti, F Novelli, B Tanno, S Leonardi, VM Hizam, C Arcangeli, L Santi, S Baschieri, C Lico, M Mancuso

International Journal of Molecular Sciences (MDPI) Italy, 17 May 2023

Pharmacology, Oncology

Key words: TBSV NPs, drug delivery system, doxorubicin, preclinical study, Ptch1+/− mice, MB therapy [more]

Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma

Y Wang, X Xiang, H Chen, L Zhou, S Chen, G Zhang, X Liu, X Ren, J Liu, M Kuang, J Jiang, J She, Z Zhang, R Xue, H Jiang, J Wang, S Peng

Cell Reports Medicine (Cell Press) China, 16 May 2023

Immunology, Oncology

[more]

Short‐term toll‐like receptor 9 inhibition leads to left ventricular wall thinning after myocardial infarction

M Lenz, A Kiss, P Haider, M Salzmann, M Brekalo, KA Krychtiuk, O Hamaza, K Huber, C Hengstenberg, BK Podesser, J Wojta, PJ Hohensinner, WS Speidl

ESC Heart Failure (Wiley) Austria, 16 May 2023

Pharmacology, Cardiology

Key words: CXCR2, Infarction, Ischaemia–reperfusion, Neutrophils, TLR9 [more]

Effects of Therapeutic Hypothermia on Macrophages in Mouse Cochlea Explants

W Bader, C Steinacher, HT Fischer, R Glueckert, J Schmutzhard, A Schrott-Fischer

International Journal of Molecular Sciences (MDPI) Austria, 16 May 2023

Otolaryngology

Key words: cochlea implant, IBA1, F4/80, CD163, CD45, immune response, inner ear, hypothermia [more]

High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway

N Zhang, YQ Wang, C Sun, Y Shi, LG Hou, M Yao, M Hu, XM Wang, PP Ma, WJ Li, LL Jiang

American Journal of Cancer Research (e-Century Publishing) China, 15 May 2023

Oncology

Key words: Peroxisomal D-bifunctional protein, hepatocellular carcinoma, HepG2, apoptosis, energy metabolism, PI3K/AKT pathway [more]

Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-κB signaling pathway activation in aged mice

Y Yao, D Lin, Y Chen, L Liu, Y Wu, X Zheng

Inflammation Research (Springer) China, 15 May 2023

Aging

Key words: Microglia, Neuroinflammation, Postoperative cognitive dysfunction, Fluoxetine, Toll-like receptor 4 [more]

Characterization of Early and Late Damage in a Mouse Model of Pelvic Radiation Disease

R Vitali, F Palone, I De Stefano, C Fiorente, F Novelli, E Pasquali, E Fratini, M Tanori, S Leonardi, B Tanno, E Colantoni, S Soldi, S Galletti, M Grimaldi, AG Morganti, L Fuccio, S Pazzaglia, C Pioli, M Mancuso, L Vesci

International Journal of Molecular Sciences (MDPI) Italy, 15 May 2023

Radiotherapy

Key words: mouse model, intestinal damage, ionizing radiation, intestinal stem cells, fecal markers [more]

Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice

C Wang, B Zhao, J Zhai, A Wang, N Cao, T Liao, R Su, L He, Y Li, X Pei, Y Jia, W Yue

Cell Death & Disease (Nature) China, 12 May 2023

Stem Cell Research

Key words: Mesenchymal stem cells, Stem-cell research [more]

Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity

M Cui, Q He, Z Wang, Y Yu, H Gao, Z Liu, H Peng, H Wang, X Zhang, D Li, L Chen, X Xing, Y Xiao, W Chen, Q Wang

Environmental Pollution (Elsevier) China, 12 May 2023

Gastroenterology

Key words: Nanoplastics, Intestinal barrier, Tight junction protein, Mucin2, IL-10 [more]

Inactivation of EGFR/ERK/NF‐κB signalling associates with radiosensitizing effect of 18β‐glycyrrhetinic acid on progression of hepatocellular carcinoma

YC Liu, CH Lin, KT Chen, DW Lai, FT Hsu

Journal of Cellular and Molecular Medicine (Wiley) Taiwan, 12 May 2023

Oncology

Key words: 18β- Glycyrrhetinic acid, epidermal growth factor receptor, ERK, hepatocellular carcinoma, NF-κB, radiotherapy [more]

Inactivation of EGFR/ERK/NF-? B signalling associates with radiosensitizing effect of 18ß-glycyrrhetinic acid on progression of hepatocellular carcinoma

L Yu-Chang, CH Lin, KT Chen, DW Lai, FT Hsu

Journal of Cellular and Molecular Medicine (Wiley) Taiwan, 12 May 2023

Oncology

Key words: 18β- Glycyrrhetinic acid, epidermal growth factor receptor, ERK, hepatocellular carcinoma, NF- κB, radiotherapy [more]

Stromal and intratumoral T cell infiltration in head and neck squamous cell carcinoma

D Krum, S Rösch, G Dyckhoff, R Warta, PK Plinkert, C Herold-Mende

Laryngo-Rhino-Otologie (thieme-connect.com) Germany, 12 May 2023

Immunology, Oncology

[more]

Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study

TC Lin, YC Tsai, YA Chen, TH Young, CC Wu, YH Chiang, CH Kao, APH Huang, KY Chen, LK Tsai

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) Taiwan, 11 May 2023

Neuroscience

Key words: cerebrospinal fluid, intracerebral hemorrhage (ICH), neurogenesis, subventricular zone (SVZ), brain-derived neurotrophic factor (BDNF) [more]

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8+ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

A Rezapour, D Rydbeck, F Byvald, V Tasselius, G Danielsson, E Angenete, U Yrlid

OncoImmunology (Taylor & Francis) Sweden, 10 May 2023

Immunology, Oncology

Key words: Granzyme B, γδ T cells, Immunoscore, Type I Interferon, MxA, Neoadjuvant treatment, Rectal Cancer, Tumor infiltrating lymphocytes [more]

Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancer

AL Berr, K Wiese, G Dos Santos, CM Koch, KR Anekalla, M Kidd, JM Davis, Y Cheng, YS Hu, KM Ridge

Oncogene (Nature) USA, 09 May 2023

Oncology

Key words: Cell death, Intermediate filaments, Non-small-cell lung cancer [more]

Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

HK So, H Kim, J Lee, CL You, CE Yun, HJ Jeong, EJ Jin, Y Jo, D Ryu, GU Bae, JS Kang

Research (AAAS) South Korea, 09 May 2023

Neuroscience

[more]

Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain

CY Ding, YT Ding, H Ji, YY Wang, X Zhang, DM Yin

Cell & Bioscience (BMC) China, 05 May 2023

Neuroscience

Key words: Neuregulin 1, Cre-reporting mice, Olfactory bulb, Striatum, Cerebral cortex, Hippocampus, Hypothalamus, cerebellum, axon projection [more]

Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC

M Li, L Duan, W Wu, W Li, L Zhao, A Li, X Lu, X He, Z Dong, K Liu, Y Jiang

Oncogenesis (Nature) China, 05 May 2023

Oncology

Key words: Cancer prevention, Oesophageal cancer, Target identification, Target validation [more]

Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis

T Zhou, Y Xie, X Hou, W Bai, X Li, Z Liu, Q Man, J Sun, D Fu, J Yan, Z Zhang, Y Wang, H Wang, W Jiang, S Gao, T Zhao, A Chang, X Wang, H Sun, X Zhang, S Yang, C Huang, J Hao, J Liu

Journal of Experimental & Clinical Cancer Research (BMC) China, USA, 04 May 2023

Oncology

Key words: Pancreatic cancer, Organoids, High-throughput drug screening, c-Jun, Irbesartan [more]

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

L Chibaya, KC Murphy, KD DeMarco, S Gopalan, H Liu, CN Parikh, Y Lopez-Diaz, M Faulkner, J Li, JP Morris IV, YJ Ho, SK Chana, J Simon, W Luan, A Kulick, E de Stanchina, K Simin, LJ Zhu, TG Fazzio, SW Lowe, M Ruscetti

Nature Cancer (Nature) USA, 04 May 2023

Oncology

Key words: Cancer, Immunosurveillance, Pancreatic cancer, Senescence, Targeted therapies [more]

Renewal of Oligodendrocyte Lineage Reverses Dysmyelination and CNS Neurodegeneration Through Corrected N-acetylaspartate Metabolism

A Lotun, D Li, H Xu, Q Su, S Tuncer, J Sanmiguel, M Mooney, CE Baer, R Ulbrich, SJ Eyles, L Strittmayer, LJ Hayward, DJ Gessler

Progress in Neurobiology (Elsevier) USA, China, Germany, 04 May 2023

Neuroscience

Key words: CNS, Neurodegeneration, Demyelination, Gene therapy, AAV, Canavan disease, N-acetylaspartate, Oligodendrocytes, Neurons [more]

Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer

M Wang, CA Wisniewski, C Xiong, P Chhoy, HL Goel, A Kumar, LJ Zhu, R Li, PA St.Louis, LM Ferreira, H Pakula, Z Xu, M Loda, Z Jiang, MA Brehm, AM Mercurio

Science Translational Medicine (Science) USA, 03 May 2023

Immunology, Oncology

[more]

The ICAM-1 ligand HRV-A89 is internalized independently of clathrin-mediated endocytosis and its capsid reaches late endosomes

B Pfanzagl

Virology (Elsevier) Austria, 03 May 2023

Cell Biology

Key words: Arf6, Chlorpromazine, Endocytosis, ICAM-1, Imipramine, Rhinovirus [more]

Androgen therapy does not prevent bone loss and arterial calcifications in male rats with chronic kidney disease

K David, V Dubois, A Verhulst, V Sommers, V Sommers, D Schollaert, L Deboel, K Moermans, G Carmeliet, P D’Haese, D Vanderschueren, F Claessens, P Evenepoel, B Decallonne , D Schollaert , L Deboel , K Moermans , G Carmeliet , P D’Haese , D Vanderschueren V Sommers , D Schollaert , L Deboel , K Moermans , G Carmeliet , P D’Haese , D Vanderschueren , F Claessens , P Evenepoel , and B Decallonne

Journal of Endocrinology (Society for Endocrinology) Belgium, 02 May 2023

Endocrinology, Hepathology

Key words: androgen replacement therapy, chronic kidney disease, hypogonadism, bone loss, arterial calcification [more]

Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain

E Stroo, L Janssen, O Sin, W Hogewerf, M Koster, L Harkema, SA Youssef, N Beschorner, AHG Wolters, B Bakker, L Becker, Lilian Garrett, S Marschall, SM Hoelter, W Wurst, H Fuchs, V Gailus-Durner, M Hrabe de Angelis, A Thathiah, F Foijer, B van de Sluis, J van Deursen, M Jucker, A de Bruin, EAA Nollen

Life Science Alliance (Life Science Alliance) The Netherlands, Portugal, Germany, Belgium, USA, 02 May 2023

Neuroscience, Developmental Biology

[more]

Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses

MM Pillat, AC Ayupe, G Juvenal, C Meinerz, T Glaser, D Vieira da Silva Pellegrina, D Souza Paiva, CF Mello, B Monteiro Longo, E Moraes Reis, H Ulrich

Stem Cell Reviews and Reports (Springer) Brazil, 02 May 2023

Immunology, Neuroscience

Key words: Neural progenitor cells, Cytokines, Degenerative disease, Neural development, Neuroinflammation [more]

Reshaping fish intestinal microbiota and facilitating barrier function by ZnO nanoparticles

S Ma, WX Wang

Environmental Science: Nano (Royal Society of Chemistry) China, 01 May 2023

Nanomedicine, Zoology

[more]

Therapeutic efficacy of a MMAE-based anti-DR5 drug conjugate Oba01 in preclinical models of pancreatic cancer

C Zheng, D Zhou, W Li, Y Duan, M Xu, J Liu, J Cheng, Y Xiao, H Xiao, T Gan, J Liang, D Zheng, L Wang, S Zhang

Cell Death & Disease (Nature) China, 29 April 2023

Oncology, Pharmacology

Key words: Preclinical research, Targeted therapies [more]

Expression-based subtypes define pathologic response to neoadjuvant immune-checkpoint inhibitors in muscle-invasive bladder cancer

AG Robertson, K Meghani, LF Cooley, KA McLaughlin, LA Fall, Z Yu, MA Castro, CS Groeneveld, A de Reyniès, VI Nazarov, VO Tsvetkov, B Choy, D Raggi, L Marandino, F Montorsi, T Powles, A Necchi, JJ Meeks

Nature Communications (Nature) Canada, USA, Brazil, France, USA, Italy, UK, 27 April 2023

Oncology

Key words: Bladder cancer, Tumour immunology [more]

Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma

TY Hsieh, WW Sung, YC Chang, CY Yu, LY Lu, C Dong, TH Lee, SL Chen

Aging (Impact Journals) Taiwan, 21 April 2023

Pharmacology, Oncology

Key words: melatonin, bladder cancer, apoptosis, NF-κB, HIF-1α [more]

Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms

YT Magalhaes, VK Boell, GD Cardella, FL Forti

Cell Death & Disease (Nature) Brazil, 21 April 2023

Oncology

Key words: Cytoskeleton, DNA damage and repair [more]

BiTE‐Secreting CAR‐γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors

SW Huang, CM Pan, YC Lin, MC Chen, Y Chen, CI Jan, CC Wu, FY Lin, ST Wang, CY Lin, WH Huang, YT Chiang, WC Tsai, YH Chiu, TH Lin, SC Chiu, DY Cho

Advanced Science (Wiley) Taiwan, 20 April 2023

Oncology, Pharmacology

[more]

Association of Neutrophil Extracellular Traps with Fistula Healing in Patients with Complex Perianal Fistulizing Crohn’s Disease

D Cao, K Qian, Y Zhao, J Hong, H Chen, X Wang, N Yang, C Zhang, J Cao, K Jia, G Wu, M Zhu, J Shen, Y Zhang, Z Cui, Z Wang

Journal of Crohn's and Colitis (Oxford Academic) China, 19 April 2023

Gastroenterology

Key words: Perianal fistulising Crohn’s disease; fistula healing; neutrophil extracellular traps. [more]

Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

O Leddy, FM White, BD Bryson

Elife (eLife Sciences Publications) USA, 19 April 2023

Immunology, Virology

[more]

BushenHuoxue decoction suppresses M1 macrophage polarization and prevents LPS induced inflammatory bone loss by activating AMPK pathway

S Chen, L Tao, F Zhu, Z Wang, Q Zhuang, Y Li, Y Yang, C Feng, H Shi, J Shi, L Zhu, L Xiao, D Geng, Z Wang

Heliyon (Cell Press) China, 19 April 2023

Immunology

Key words: Inflammatory bone loss, Bushen huoxue decoction, Inflammation, Macrophage polarization, Bone immune regulation [more]

Targeting YAP1 ameliorates progesterone resistance in endometriosis

SC Lin, WN Li, SC Lin, HT Hou, YC Tsai, TC Lin, MH Wu, SJ Tsai

Human Reproduction (Oxford Academic) Taiwan, 18 April 2023

Reproductive Medicine

Key words: YAP1, miR-21-5p, PGR, progesterone resistance, endometriosis [more]

IKKα inhibition re-sensitizes acquired adriamycin-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis

J Liao, Q Qin, F Lv, Z Huang, B Lian, C Wei, Q Mo, QX Tan

Scientific Reports (Nature) China, 17 April 2023

Oncology, Pharmacology

Key words: Cancer, Chemical biology, Diseases, Genetics [more]

Adiponectin reverses β‐Cell damage and impaired insulin secretion induced by obesity

AC Munhoz, JDC Serna, EA Vilas‐Boas, CC Caldeira da Silva, TG Santos, FC Mosele, SL Felisbino, VR Martins, AJ Kowaltowski

Aging Cell (Wiley) Brazil, 14 April 2023

Endocrinology

Key words: adiponectin, calorie restriction, diabetes, obesity, oxidative phosphorylation [more]

Upregulation of dendrocyte-expressed seven transmembrane protein is associated with unfavorable outcomes in differentiated thyroid cancer

JJ Lee, YC Hsu, WC Huang, SP Cheng

Endocrine (Springer) Taiwan, 14 April 2023

Oncology, Pharmacology

Key words: DCSTAMP, Recurrence, Survival, Thyroid cancer, Immunohistochemistry [more]

Single-cell transcriptome analysis revealed the immune profile of PD-1 blockade in gallbladder carcinoma liver metastasis

L Xie, Z Ning, Y Hua, P Wang, Z Meng

Hepatology Communications (Wiley) China, 14 April 2023

Oncology

[more]

Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity

VA Onofrei, E Anisie, CL Zamfir, A Ceasovschih, M Constantin, F Mitu, ED Grigorescu, AD Petroaie, DV Timofte

Journal of Clinical Medicine (MDPI) Romania, 14 April 2023

Endocrinology, Oncology

Key words: arterial stiffness, adipokines, morbid obesity, cardiovascular risk, perivascular adipose tissue [more]

The effects of mild hypothermia on the electrode insertion trauma in a murine whole organ cochlea culture

J Schmutzhard, W Bader, T Gottfried, D Dejaco, R Glückert, J Dudas, A Schrott-Fischer

Frontiers in Neuroscience (Frontiers Media S.A.) Austria, 13 April 2023

Pathology

Key words: hypothermia, whole organ cochlea culture, electrode insertion trauma, cochlear implant, sensorineural hearing loss, hearing rehabilitation [more]

Yellow mealworm (Tenebrio Molitor) enhances intestinal immunity in largemouth bass (Micropterus salmoides) via the NFκB/survivin signaling pathway

C Ge, X Liang, X Wu, J Wang, H Wang, Y Qin, M Xue

Fish & Shellfish Immunology (Elsevier) China, 11 April 2023

Zoology

Key words: Yellow mealworm, Largemouth bass, Intestinal immunity, NFκBp65, Survivin [more]

Axonal mapping of motor and sensory components within the ulnar nerve and its branches

V Tereshenko, U Maierhofer, LA Hruby, J Klepetko, DC Dotzauer, O Politikou, G Laengle, M Luft, C Festin, R Blumer, KD Bergmeister, OC Aszmann

Journal of Neurosurgery (American Association of Neurological Surgeons) Austria, 07 April 2023

Neuroscience

Key words: axon count, flexor carpi ulnaris muscle, flexor digitorum profundus muscle, nerve transfer, deep branch of the ulnar nerve, superficial branch of the ulnar nerve, peripheral nerve, anatomy [more]

Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia

Q Jiang, J Stachelscheid, J Bloehdorn, A Pacholewska, C Markus A, F Grotenhuijs, TA Müller, O Onder, P Wagle, CD Herling, M Kleppe, Z Wang, KR Coombes, S Robrecht, PS Dalvi, BA Lungu, P Mayer, LV Abruzzo, J Altmüller, BS Gathof, T Persigehl, K Fischer, BMC Jebaraj, H Young Rienhoff Jr, RC Ecker, Y Zhao, CJ Bruns, S Stilgenbauer, KSJ Elenitoba-Johnson, M Hallek, MR Schweiger, M Odenthal, E Vasyutina, M Herling

Blood (ASH Publications) Germany, USA, China, Romania, Austria, Australia, 06 April 2023

Oncology

Key words: chronic lymphocytic leukemia, TCL1A, KDM1A, epigenetics, histone modulation [more]

Neuroprotective effects of resistance physical exercise on the APP/PS1 mouse model of Alzheimer's disease

HC Campos, DE Ribeiro, D Hashiguchi, DY Hukuda, C Gimenes, D Suchecki, RM Arida, H Ulrich, B Monteiro Longo

Frontiers in Neuroscience (Frontiers Media S.A.) Brazil, 06 April 2023

Pharmacology, Neuroscience

Key words: Alzheimer’s disease, resistance exercise, locomotor activity, corticosterone, amyloid-beta precursor protein [more]

Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis

N Das, LGN de Almeida, A Derakhshani, D Young, K Mehdinejadiani, P Salo, A Rezansoff, GD Jay, CP Sommerhoff, TA Schmidt, R Krawetz, A Dufour

Nature Communications (Nature) Canada, USA, Germany, 06 April 2023

Osteology

Key words: Biochemical networks, Proteases, Proteolysis, Rheumatology [more]

Prognostic values of tissue-resident CD8+ T cells in human hepatocellular carcinoma and intrahepatic cholangiocarcinoma

L Chen, H Huang, Z Huang, J Chen, Y Liu, Y Wu, A Li, J Ge, Z Fang, B Xu, X Zheng, C Wu

World Journal of Surgical Oncology (BMC) China, 06 April 2023

Oncology

Key words: Hepatocellular carcinoma, Intrahepatic Cholangiocarcinoma, Multicolor immunohistochemistry, Prognosis, Tissue-resident CD103+CD8+T cells [more]

Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma

T Zhou, Q Man, X Li, Y Xie, X Hou, H Wang, J Yan, X Wei, W Bai, Z Liu, J Liu, J Hao

Cancer Biology & Medicine (China Anti-Cancer Association) China, 05 April 2023

Oncology, Machine Learning

Key words: Artificial intelligence, CD8, CSCs, tumor budding, PDAC, nomogram [more]

Hypoxia switches TET1 from being tumor-suppressive to oncogenic

Q Yang, H Dang, J Liu, X Wang, J Wang, X Lan, M Ji, M Xing, P Hou

Oncogene (Nature) China, 05 April 2023

Oncology

Key words: Cancer microenvironment, Oncogenes [more]

Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses

Q Zeng, S Wang, M Li, S Wang, C Guo, X Ruan, R Watanabe, Y Lai, Y Huang, X Yin, C Zhang, B Chen, N Yang, H Zhang

Cell Metabolism (Cell Press) China, Japan, 04 April 2023

Immunology

Key words: CD36, acetylcholine, autoreactive B cell responses, choline acetyltransferase, fibroblastic reticular cells, lipid metabolism, mitochondrial respiration, spleen, systemic lupus erythematosus [more]

Molecules of senescent glial cells differentiate Alzheimer's disease from ageing

L Dai, F Gao, Q Wang, X Lv, Z Cheng, Y Wu, X Chai, H Zetterberg, K Blennow, AI Levey, J Shi, Y Shen

Journal of Neurology, Neurosurgery & Psychiatry (BMJ Journals) China, Sweden, UK, USA, 04 April 2023

Neuroscience

[more]

Red blood cell extracellular vesicles deliver therapeutic siRNAs to skeletal muscles for treatment of cancer cachexia

B Peng, Y Yang, Z Wu, R Tan, TT Pham, EYM Yeo, M Pirisinu, MK Jayasinghe, TC Pham, K Liang, N Shyh-Chang, MTN Le

Molecular Therapy (Cell Press) Singapore, China, 04 April 2023

Oncology

Key words: extracellular vesicles, cancer cachexia, siRNA, RNA delivery, myostatin, malonyl-CoA decarboxylase [more]

Characterization and Advancement of an Evaluation Method for the Treatment of Spontaneous Osteoarthritis in STR/ort Mice: GRGDS Peptides as a Potential Treatment for Osteoarthritis

MF Chen, CC Hu, YH Hsu, YT Chiu, KL Chen, SWN Ueng, Y Chang

Biomedicines (MDPI) Taiwan, 02 April 2023

Osteology

Key words: Osteoarthritis, STR/ort, cartilage, matrix metallopeptidase-13, SRY-box transcription factor 91 [more]

A Deep-Learning-Computed Cancer Score for the Identification of Human Hepatocellular Carcinoma Area Based on a Six-Colour Multiplex Immunofluorescence Panel

A Dievernich, J Stegmaier, P Achenbach, S Warkentin, T Braunschweig, UP Neumann, U Klinge

Cells (MDPI) Germany, The Netherlands, 02 April 2023

Osteology, Machine Learning

Key words: hepatocellular carcinoma, HCC, convolutional neural network, CNN, U-net, multiplex, fluorescence, immunofluorescence, microscopy, cancer score [more]

Analysis of Single- and Double-Stranded DNA Damage in Osteoblastic Cells after Hyperbaric Oxygen Exposure

N Schönrock, F Tillmans, S Sebens, W Kähler, S Klapa, B Rieger, H Scherthan, A Koch

Antioxidants (MDPI) Germany, USA, 01 April 2023

Pharmacology

Key words: oxidative stress; DNA damage; osteoblasts; gamma-H2AX; hyperbaric hyperoxia; comet assay; DSBs [more]

Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue

N Chen, M Yuan, NN Zhang, M Chen, R Liu, J Wang, P Lu

iScience (Cell Press) China, 01 April 2023

Cell Biology

Key words: β-catenin, UCP1, thermogenesis, beige adipocytes, energy expenditure [more]

DARPP‐32 cells and neuropil define striosomal system and isolated matrix cells in human striatum

CJ Arasaratnam, JJ Song, T Yoshida, MA Curtis, AM Graybiel, RLM Faull, HJ Waldvogel

Journal of Comparative Neurology (Wiley) New Zealand, USA, 31 March 2023

Neuroscience

Key words: DARPP-32, spinyprojectionneurons, striatum, striosomes [more]

High bacillary burden and the ESX-1 type VII secretion system promote MHC class I presentation by Mycobacterium tuberculosis infected macrophages to CD8 T-cells

D Mott, J Yang, C Baer, K Papavinasasundaram, CM Sassetti, SM Behar

The Journal of Immunology (AHA Journals) USA, 31 March 2023

Immunology, Microbiology

Optimizing culturing conditions in patient derived 3D primary slice cultures of head and neck cancer

M do Carmo Greier, A Runge, J Dudas, L Carpentari, VH Schartinger, A Randhawa, M Mayr, M Petersson, H Riechelmann

Frontiers in Oncology (Frontiers Media S.A.) Austria, 30 March 2023

Biological Methods, Oncology

Key words: head and neck cancer, tumor microenvironment, cultured neoplastic cells, platelet rich fibrin, culture media [more]

Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy

T Dong, ZQ Zhang, LH Sun, W Zhang, Z Zhu, L Lin, Lin Yang, A Lv, C Liu, Q Li, RF Yang, X Zhang, Y Niu, HZ Chen, DP Liu, WM Tong

Brain Pathology (Wiley) China, 28 March 2023

Neuroscience

Key words: antioxidant, Mic60, mitochondria, mitochondrial encephalomyopathies, neurodegeneration, reactive oxygen species [more]

CD226 identifies functional CD8+ T cells in the tumor microenvironment and predicts a better outcome for human gastric cancer

H Huang, Z Huang, J Ge, J Yang, J Chen, B Xu, S Wu, X Zheng, L Chen, X Zhang, J Jiang

Frontiers in Immunology (Frontiers Media S.A.) China, 28 March 2023

Oncology, Gastroenterology

Key words: CD226, CD8+ T cells, multi-color immunohistochemical staining, prognosis, gastric cancer [more]

Protective effects of resveratrol on the ethanol‐induced disruption of retinogenesis in pluripotent stem cell‐derived organoids

H Li, L Gao, Z Ye, J Du, W Li, L Liang, Q Zeng, J Xi, W Yue, Z Li

FEBS Open Bio (Wiley) China, 27 March 2023

Ophthalmology

Key words: ethanol, fetal alcohol syndrome, PI3K-AKT signalling, resveratrol, retinal organoids [more]

Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages

X Li, X Chen, S Gong, J Zhao, C Yao, H Zhu, R Xiao, Y Qin, R Li, N Sun, X Li, F Dong, T Zhao, Y Pan, J Yang

Theranostics (Ivyspring International Publisher) China, 27 March 2023

Immunology, Oncology

Key words: Platelets, TAMs, CRC, PSGL-1/JNK/STAT1, C5a/C5aR1 [more]

Functional Peptide-Loaded Gelatin Nanoparticles as Eyedrops for Cornea Neovascularization Treatment

YC Chu, HW Fang, YY Wu, YJ Tang, EH Hsieh, Y She, CY Chang, IC Lin, YJ Chen, GS Liu, CL Tseng

International Journal of Nanomedicine (Taylor & Francis) Taiwan, Australia, 23 March 2023

Nanomedicine, Ophthalmology

Key words: gp91 peptide, gelatin, nanoparticles, ocular retention, control release, corneal neovascularization, eye drops [more]

Occurrence, risk assessment, and in vitro and in vivo toxicity of antibiotics in surface water in China

C Zhang, Y Chen, S Chen, X Guan, Y Zhong, Q Yang

Ecotoxicology and Environmental Safety (Elsevier) China, 22 March 2023

Toxicology, Ecology

Key words: Antibiotics, Environmental pollution, Surface water, Intestinal flora, Oxidative stress [more]

Dual-Ratiometric Magnetic Resonance Tunable Nanoprobe with Acidic-microenvironment-responsive Property to Enhance the Visualization of Early Tumor Pathological Changes

R Cao, N Tang, Y Zhu, A Chen, Y Li, R Ge, Y Li, Z Huang, J Guo, J Deng, H Lu, Z Lu, H Forgham, TP Davis, R Qiao, Z Wang

Nano Research (Sciopen) China, USA, Australia, 22 March 2023

Nanomedicine, Oncology

Key words: ratiometric nanoprobe, dually activatable, microenvironment visualization, early diagnosis, pathological changes [more]

Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization

D Chen, N Hu, S Xing, L Yang, F Zhang, S Guo, S Liu, X Ma, X Liang, H Ma

Journal of Ovarian Research (BMC) China, 21 March 2023

Reproductive Medicine

Key words: Placental mesenchymal stem cells, Premature ovarian insufficiency, Macrophage, Inflammasome, NLRP3, Interferon-γ, Pyroptosis [more]

Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy

GS Dunlap, D DiToro, J Henderson, SI Shah, M Manos, M Severgnini, A Weins, I Guleria, PA Ott, N Murakami, DA Rao

Nature Communications (Nature) USA, 21 March 2023

Immunology, Transplantation Medicine

Key words: Graft-versus-host disease, Immunotherapy, Kidney, Transplant immunology, Tumour immunology [more]

Analysis of the mechanism underlying diabetic wound healing acceleration by Calycosin-7-glycoside using network pharmacology and molecular docking

J Chen, H Ma, Y Meng, Q Liu, Y Wang, Y Lin, D Yang, W Yao, Y Wang, X He, P Li

Phytomedicine (Elsevier) China, 20 March 2023

Pharmacology

Key words: Diabetic wound healing, Calycosin-7-glucoside, Mitochondrial metabolism, Macrophage polarization, Network pharmacology, Molecular docking [more]

Intrinsic RIG-I restrains STAT5 activation to modulate anti-tumor activity of CD8+ T cells

X Jiang, J Lin, C Shangguan, X Wang, B Xiang, J Chen, H Guo, W Zhang, J Zhang, Y Shi, J Zhu, H Yang

The Journal of Clinical Investigation (American Society for Journal of Clinical Investigation) China, 16 March 2023

Immunology, Oncology

Key words: RIG-I, Tumor-infiltrating CD8+ , T cell, STAT5 activation, Colon cancer [more]

Thorium (IV) Triggers Ferroptosis through Disrupting Iron Homeostasis and Heme Metabolism in the Liver Following Oral Ingestion

M Ma, R Wang, M Xu

Journal of Hazardous Materials (Elsevier) China, 15 March 2023

Hepathology

Key words: Thorium, Hepatotoxicity, Ferroptosis, Iron homeostasis, Heme metabolism [more]

Fast and sensitive GCaMP calcium indicators for imaging neural populations

Y Zhang, M Rózsa, Y Liang, D Bushey, Z Wei, J Zheng, D Reep, GJ Broussard, A Tsang, G Tsegaye, S Narayan, CJ Obara, JX Lim, R Patel, R Zhang, MB Ahrens, GC Turner, SSH Wang, WL Korff, ER Schreiter, K Svoboda, JP Hasseman, I Kolb, LL Looger

Nature (Nature) USA, 15 March 2023

Neuroscience

Key words: Fluorescent proteins, Neural circuits [more]

Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer

Z Valko, Z Megyesfalvi, A Schwendenwein, C Lang, S Paku, N Barany, B Ferencz, A Horvath-Rozsas, I Kovacs, E Schlegl, V Pozonec, K Boettiger, M Rezeli, G Marko-Varga, F Renyi-Vamos, M Alireza Hoda, T Klikovits, K Hoetzenecker, Michael Grusch, V Laszlo, B Dome, K Schelch

British Journal of Cancer (Nature) Austria, Hungary, Sweden, 14 March 2023

Oncology

Key words: Small-cell lung cancer [more]

Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma

J Chen, K Liu, Y Luo, M Kang, J Wang, G Chen, J Qi, W Wu, B Wang, Y Han, L Shi, K Wang, X Han, X Ma, W Liu, Y Ding, L Wang, H Liang, L Wang, J Chen

Gastroenterology (Elsevier) China, USA, 14 March 2023

Oncology

Key words: Gastric Cancer, T-Cell State, CXCL13, Immune Checkpoint Blockade [more]

Expression of Checkpoint Molecules in the Tumor Microenvironment of Intrahepatic Cholangiocarcinoma: Implications for Immune Checkpoint Blockade Therapy

L Heij, J Bednarsch, X Tan, M Rosin, S Appinger, K Reichel, D Pecina, M Doukas, RM Van Dam, J Garcia Vallejo, F ulmer, S Lang, T Luedde, FG Rocha, S Sivakumar, UP Neumann

Cells (MDPI) Germany, The Netherlands, USA, UK, 09 March 2023

Oncology, Immunology

Key words: cholangiocarcinoma, tumor microenvironment, checkpoint molecules, multiplexed imaging, immunotherapy [more]

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

VN Hariharan, M Shin, CW Chang, D O'Reilly, A Biscans, K Yamada, Z Guo, M Somasundaran, Q Tang, K Monopoli, PM Krishnamurthy, G Devi, N McHugh, DA Cooper, D Echeverria, J Cruz, IL Chan, P Liu, SY Lim, J McConnell, S Prakash Singh, S Hildebrand, J Sousa, SM Davis, Z Kennedy, C Ferguson, BMD Godinho, Y Thillier, J Caiazzi, S Ly, M Muhuri, K Kelly, F Humphries, A Cousineau, KM Parsi, Q Li, Y Wang, R Maehr, G Gao, D Korkin, WM McDougall, RW Finberg, KA Fitzgerald, JP Wang, JK Watts, A Khvorova

PNAS (Proceedings of the National Academy of Sciences of the United States of America) USA, 09 March 2023

SARS-CoV-2, Immunology

Key words: SARS-COV-2, antisense oligos, small interfering RNAs, mouse model, lung [more]

Effects of paraprobiotics on bile acid metabolism and liver health in largemouth bass (Micropterus salmoides) fed a cottonseed protein concentrate-based diet

X Xie, X Liang, H Wang, Q Zhu, J Wang, Y Chang, E Leclercq, M Xue, J Wang

Animal Nutrition (Elsevier) China, France, 07 March 2023

Zoology

Key words: Cottonseed protein concentrate, Multi-yeast strain fractions, Micropterus salmoides, Liver health, Bile acid metabolism, Gut microbiota [more]

In Situ Formation of Injectable Gelatin Methacryloyl (GelMA) Hydrogels for Effective Intraocular Delivery of Triamcinolone Acetonide

C Shen, X Zhao, Z Ren, B Yang, X Wang, A Hu, J Hu

International Journal of Molecular Sciences (MDPI) China, 04 March 2023

Pharmacology

Key words: gelatin methacryloyl, triamcinolone acetonide, retina hydrogel system, hydrogel drug release, intraocular drug delivery, injectable gel [more]

The protective effect of cannabinoids against colorectal cancer cachexia through modulation of inflammation and immune responses

SK Ng, DJ Chung, LC Chang, CK Luo, SH Jwo, YH Lee, JS Lin, CH Wang, TT Wei

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 03 March 2023

Immunology, Oncology

Key words: Colorectal cancer cachexia, Cytokines, Cannabinoids, CD8+ T cell, Cannabinoid receptor 2 [more]

Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration

LW Lin, SW Wang, WC Huang, TK Huynh, CY Lai, CY Ko, YC Fong, JJ Lee, SF Yang, CH Tang

Cells (MDPI) Taiwan, 03 March 2023

Aging

Key words: melatonin, endothelial progenitor cells, vascular endothelial growth factor (VEGF), platelet-derived growth factor-BB (PDGF-BB), angiogenesis, neovascular age-related macular degeneration [more]