P2X7 receptor

FEATURED PUBLICATION

P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma
Frontiers in Oncology

Arnaud-Sampaio et al. addressed the persistent problem of drug resistance in cancer and elucidated the role of the P2X7 receptor in chemoresistance, using TissueFAXS platform for image acquisition and StrataQuest software for in-depth cytometric quantifications. The paper was published in Frontiers in Oncology.

Cytotoxic CD8+ T cells may be drivers

FEATURED PUBLICATION

Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome
scientific reports

In this study, published in scientific reports Nature, Kaneko et al. investigated the role of CD4+ and CD8+ T cell subsets in salivary glands of patients with Sjögren’s syndrome. In order to perform an in-depth quantitative analysis, the power of TissueFAXS platform, and both TissueQuest and StrataQuest software were utilized.

Adverse Effects of Single

FEATURED PUBLICATION

A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells
cancers

This study from Liang et al. (University of Gothenburg) assessed phenotypic and functional characteristics of tumor infiltrating lymphocytes within colorectal liver metastases (CRLM). For the in-situ tissue cytometry analysis, with the main focus on CD103+CD8+ TRM cells, the power of TissueFAXS CHROMA and StrataQuest was utilized.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

The role of S100A9

FEATURED PUBLICATION

The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells
Cancer Immunology, Immunotherapy

Kung et al. recently published a study, in the journal Cancer, evaluating the prognostic role of S100A9 (acting as chemoattractant for circulatory monocytes) in pancreatic ductal adenocarcinoma as well as its influence on PD-L1 expression. TissueFAXS PLUS and StrataQuest were used to assess co-expression of PD-L1 and S100A9 in human PDAC tissues.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Differential localization

FEATURED PUBLICATION

Differential localization and limited cytotoxic potential of duodenal CD8+ T cells
The Journal of Clinical Investigation

In a recent study published in The Journal of Clinical Investigation, Mvaya et al. were able to demonstrate the limited potential of duodenal CD8+ T cells in tissue samples from people living with HIV. High content immunophenotyping within duodenal tissue sections was performed using TissueFAXS i PLUS and the single cell analysis software TissueQuest.

Azvudine

FEATURED PUBLICATION

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients
Signal Transduction and Targeted Therapy

Zhang et al, published a study in the journal Signal Transduction Targeted Therapy, with the main focus on the investigation of the effect of Azvudine, in SARS-CoV-2 infected rhesus macaques as well as in COVID-19 patients. The group used TissueFAXS Q as well as TissueQuest to quantify the viral load, immune-status and TUNEL staining within thymus tissues.

Functional Impairment

FEATURED PUBLICATION

Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia
Immunity

In a recent study published in the journal Immunity, Collins et al (Ragon Institute of MGH, MIT and Harvard) were able to show key immunologic and virologic parameters of durable HIV control. For high resolution visualization of the virus, lymph node tissues were marked with HIV specific RNAScope probes and acquired using TissueFAXS Q.

AC-265347 Inhibits

FEATURED PUBLICATION

AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia
International Journal of Molecular Sciences

This recently published study was conducted within the CaSR Biomedicine Training network. Gonçalves-Alves et al. were able to demonstrate the inhibitory effect of the drug AC-265347 on neuroblastoma tumor growth. Expression of various markers (Ki67, CaSR, CD44, TrkA, NF68) was assessed by using TissueFAXS PLUS and StrataQuest.

Filter publications

Customer Publications (A total of 2213 papers published)

401
Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity

V Azzimato, P Chen, E Barreby, C Morgantini, L Levi, A Vankova, J Jager, A Sulen, M Diotallevi, JX Shen, A Miller, E Ellis, M Rydén, E Näslund, A Thorell, VM Lauschke, KM Channon, MJ Crabtree, A Haschemi, Sm Craige, M Mori, F Spallotta, M Aouadi

Gastroenterology (Elsevier) Sweden, France, UK, Austria, Germany, USA, Italy, 21 August 2021

Gastroenterology

Key words: Liver, Metabolism, Oxidative Stress, miRNAs, Fumarase

Organism: Human

Tissue: Liver

Pathological State: Obesity

402
Spatially Resolved Immunometabolism to Understand Infectious Disease Progression

R Tans, S Dey, NS Dey, G Calder, P O'Toole, PM Kaye, RMA Heeren

Frontiers in Microbiology (Frontiers Media S.A.) The Netherlands, UK, 19 August 2021

Immunology

Key words: Immunometabolism, Infectious Disease, Inflammation, Granulomas, Mass Spectrometry Imaging, Spatial Transcriptomics, Multi-Omics, Leishmaniasis

403
Maternal Immune Activation Causes Social Behavior Deficits and Hypomyelination in Male Rat Offspring with an Autism-Like Microbiota Profile

GA Lee, YK Lin, JH Lai, YC Lo, YCSH Yang, SY Ye, CJ Lee, CC Wang, YH Chiang, SH Tseng

Brain Sciences (MDPI) Taiwan, 18 August 2021

Neuroscience

Key words: Autism Spectrum Disorder, Lipopolysaccharide, Maternal Immune Activation, Microbiota, Three-Chamber Test, Myelination, Brain–Gut–Microbiota Axis, Social Behavior Deficits

Organism: Rat

Tissue: Brain

404
Effects of Vitamin D-Deficient Diet on Intestinal Epithelial Integrity and Zonulin Expression in a C57BL/6 Mouse Model

CY Yeung, JSC Chiau, ML Cheng, WT Chan, CB Jiang, SW Chang, CY Liu, CW Chang, HC Lee

Frontiers in Medicine (Frontiers Media S.A.) Taiwan, 16 August 2021

Gastroenterology

Key words: Vitamin D, Gut Integrity, Tight Junction, Zonulin, Leaky Gut

Organism: Mouse

Tissue: Small Intestine, Colon

405
A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge

X He, L Ding, K Cao, H Peng, C Gu, Y Li, D Li, L Dong, X Hong, X Wang, M Fu, C Qiu, C Zhu, Z Zhang, S Song, C Wang, Z Jiang, Y Xie, Z Qi, C Zhao, P Zhao, X Zhang, J Xu

Emerging Microbes & Infections (Taylor & Francis) China, 12 August 2021

SARS-CoV-2

Key words: SARS-CoV-2, Cell-Based Vaccines, K562-S, Mouse Model, Non-Human Primate Model, Neutralizing Antibody, Protection

Organism: Human

Pathological State: COVID-19

Cell Line: K562 cells

406
Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus

D Douchi, A Yamamura, J Matsuo, YHM Lim, N Nuttonmanit, M Shimura, K Suda, S Chen, S Pang, K Kohu, T Abe, G Shioi, G Kim, A Shabbir, S Srivastava, M Unno, JBY So, M Teh, KG Yeoh, LSH Chuang, Y Ito

Gastroenterology (Elsevier) Singapore, Japan, 12 August 2021

Gastroenterology

Key words: Metaplasia, Intramucosal Dysplasia, Invasive and Metastatic Gastric Cancer, Gastric Carcinogenesis, Mouse Model

Organism: Mouse

Tissue: Stomach

Pathological State: Cancer

407
Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells

L Kappert, P Ruzicka, A Kutikhin, C De La Torre, A Fischer, M Hecker, C Arnold, T Korff

The FASEB Journal (Wiley) Germany, Russia, 12 August 2021

Cardiology

Organism: Human

Cell Line: Human Arterial Smooth Muscle Cells

408
The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells

PJ Kung, TY Lai, J Cao, LC Hsu, TC Chiang, P Ou-Yang, CY Tsai, YF Tsai, CW Lin, CC Chen, MK Tsai, YW Tien, CY Lee

Cancer Immunology, Immunotherpay (Springer) Taiwan, Australia, 10 August 2021

Oncology, Immunology

Key words: S100A9, PD-L1, Pancreatic Ductal Adenocarcinoma, PSC

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

409
Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer

E Shrestha, JB Coulter, W Guzman, B Ozbek, MM Hess, L Mummert, SE Ernst, JP Maynard, AK Meeker, CM Heaphy, MC Haffner, AM De Marzo, KS Sfanos

PNAS (United States National Academy of Sciences) USA, 10 August 2021

Oncology

Key words: Prostate Cancer, Infection, Inflammation, TMPRSS2:ERG Fusion, Colibactin

Organism: Human

Tissue: Prostate

Pathological State: Cancer

410
Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultraviolet Light–Induced Pterygium

CC Lai, SH Tseng, SM Hsu, YT Huang, CC Shieh

Investigative Ophthalmology & Visual Science (ARVO Journals) Taiwan, 09 August 2021

Ophthalmology

Key words: Pterygium, Pterygial Epithelial Cells, Toll-Like Receptor 3, Ultraviolet B, NF-κB

Organism: Human

Tissue: Eye

Pathological State: Pterygium

411
Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer

SC Wang, YC Chang, MY Wu, CY Yu, SL Chen, WW Sung

Cancers (MDPI) Taiwan, 04 August 2021

Oncology

Key words: Bladder Cancer, Azacitidine, Intravesical Instillation, TNF-R1, TRAIL-R2

Organism: Rat

Tissue: Bladder

Pathological State: Cancer

412
Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway

X Wu, Z Wang, Y Jiang, H Zhou, A Li, Y Wie, Z Bao, D Wang, J Zhao, X Chen, Y Guo, Z Dong, K Liu

Frontiers in Oncology (Frontiers Media S.A.) China, 04 August 2021

Oncology

Key words: Esophageal Squamous Cell Carcinoma, Tegaserod Maleate, Proteome, Peroxisome, Peroxisome Membrane Protein 11B, Peroxisome Membrane Protein 13, Patient-Derived Xenograft

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

413
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

LC Russo, R Tomasin, IA Matos, AC Manucci, ST Sowa, K Dale, KW Caldecott, L Lehtiö, D Schechtman, FC Meotti, A Bruni-Cardoso, NC Hoch

Journal of Biological Chemistry (ASBMB) Brazil, Finland, UK, 04 August 2021

SARS-CoV-2, Immunology

Key words: COVID-19, SARS-CoV-2, ADP-ribosylation, PARP9, DTX3L, macrodomain

Organism: Human

Pathological State: COVID-19

Cell Line: A549 lung adenocarcinoma cells

414
The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca2+ overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-γ/IP3R signaling pathway

T Gao, P Yang, D Fu, M Liu, X Deng, M Shao, J Liao, H Jiang, X Li

Aging (Impact Journals) China, 03 August 2021

Cardiology

Key words: Allicin, Apoptosis, PI3K/Akt Pathway, Myocardial Ischemia/Reperfusion, Gene Expression Profiling, Calcium Signaling Pathway, GRK2, GPCR

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Ischemia

415
Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma

M Ma, G Li, M Qi, W Jiang, R Zhou

Frontiers in Immunology (Frontiers Media S.A.) China, 03 August 2021

Immunology

Key words: Asthma, Inflammasome, HDM, Alveolar Macrophage, RRx-001, NLRP3

Organism: Mouse

Tissue: Lung

Pathological State: Asthma

416
High-Precision Quantitative Analysis Reveals Carcinoembryonic Protein Expression Differs Among Colorectal Cancer Primary Foci and Metastases to Different Sites

Y Zhu, Q Zhang, C Wei, Y Hu, H Gong, Y Liu, H Lai, Y Feng, Y Lin

Technology in Cancer Research & Treatment (SAGE Journals) China, 03 August 2021

Oncology

Key words: Carcinoembryonic Protein, Colorectal Cancer, Lymph Node Metastases, Liver Metastases, Primary Foci

Organism: Human

Tissue: Colon

Pathological State: Cancer

417
Conifer essential oils reversed amyloid beta1-42 action by modulating BDNF and ARC expression in the rat hippocampus

PA Postu, A Tiron, CE Tiron, DL Gorgan, M Mihasan, L Hritcu

CNS & Neurological Disorders (ingentaconnect) Romania, 30 July 2021

Neuroscience

Key words: Alzheimer’s disease, Pinus halepensis, Tetraclinis articulata, amyloid-beta peptide, memory, neuroprotection

Pathological State: Alzheimer's Disease

418
Causal evidence for induction of pessimistic decision-making in primates by the network of frontal cortex and striosomes

S Amemori, AM Graybiel, K Amemori

Frontiers in Neuroscience (Frontiers Media S.A.) Japan, USA, 30 July 2021

Neuroscience

Key words: Anxiety, Caudal Orbitofrontal Cortex, Pregenual Anterior Cingulate Cortex, Approach-Avoidance Conflict, Monkey, Microstimulation, Striosome Compartment, Caudate Nucleus

Organism: Monkey

Tissue: Brain

419
S-nitroso human serum albumin as a nitric oxide donor in drug-eluting vascular grafts: biofunctionality and preclinical evaluation

M Enayati, KH Schneider, C Almeria, C Grasl, C Kaun, B Messner, S Rohringer, I Walter, J Wojta, L Budinsky, BH Walpoth, H Schima, G Kager, S Hallström, BK Podesser, H Bergmeister

Acta Biomaterialia (Elsevier) Austria, Slovakia, Switzerland, 28 July 2021

Cardiology

Key words: Nitric Oxide Donor, Drug Eluting Vascular Graft, Poly-Caprolactone, Electrospinning

Organism: Rat

Tissue: Blood Vessels

Pathological State: Vascular Graft

420
Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV

AK Mattox, J Roelands, TM Saal, Y Cheng, D Rinchai, W Hendrickx, GD Young, TJ Diefenbach, AE Berger, WH Westra, JA Bishop, WC Faquin, FM Marincola, MJ Pittet, D Bedognetti, SI Pai

The American Journal of Pathology (Elsevier) USA, Qatar, The Netherlands, 23 July 2021

Virology

Organism: Human

Tissue: Tonsil

Pathological State: HPV Infection

421
Liposomal IR-780 as a Highly Stable Nanotheranostic Agent for Improved Photothermal/Photodynamic Therapy of Brain Tumors by Convection-Enhanced Delivery

YJ Lu, TS Anikumar, CC Chuang, JP Chen

Cancers (MDPI) Taiwan, 22 July 2021

Oncology

Key words: Nanomedicine, Cancer Therapy, Brain Tumor, Photothermal Therapy, Photodynamic Therapy, Liposome, IR-780, Convection Enhanced Delivery

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

422
Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning

WH Yang, JS Westman, DM Heithoff, M Sperandio, JW Cho, MJ Mahan, JD Marth

PNAS (United States National Academy of Sciences) USA, South Korea, Germany, 20 July 2021

Gastroenterology

Key words: Colitis, Neuraminidase, Inflammation

Organism: Mouse

Tissue: Small Intestine

Pathological State: Colitis

423
Electromagnetic Field‐Programmed Magnetic Vortex Nanodelivery System for Efficacious Cancer Therapy

X Liu, Y Zhang, Y Guo, W Jiao, X Gao, WSV Lee, Y Wang, X Deng, Y He, J Jiao, C Zhang, G Hu, XJ Liang, H Fan

Advanced Science (Wiley) China, Singapore, 18 July 2021

Nanomedicine, Oncology

Organism: Mouse

Tissue: Breast, Xenograft Tumor

Pathological State: Cancer

424
Effect of high fat diet on the severity and repair of lung fibrosis in mice

AE Hegab, M Ozaki, S Kagawa, K Fukunaga

Stem Cells and Development (Mary Ann Liebert Inc.) Japan, 16 July 2021

Endocrinology, Pulmonology

Key words: High Fat Diet, Fibrosis, Alveolar Type-2 Cells, Bronchioalveolar Stem Cells, Fatty Acid Oxidation

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

425
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

R Fardoos, OE Asowata, N Herbert, SK Nyquist, Y Zungu, A Singh, A Ngoepe, IM Mbano, N Mthabela, D Ramjit, F Karim, W Kuhn, FG Madela, VT Manzini, F Anderson, B Berger, TH Pers, AK Shalek, A Leslie, H Kløverpris

JCI Insight (The American Society for Clinical Investigation) Denmark, South Africa, USA, 12 July 2021

SARS-CoV-2

Key words: AIDS/HIV, Covid-19

Organism: Human

Tissue: Colon

Pathological State: HIV Infection

426
Down-regulation of A20 promotes immune escape of lung adenocarcinomas

K Breitenecker, M Homolya, AC Luca, V Lang, C Trenk, G Petroczi, J Mohrherr, J Horvath, S Moritsch, L Haas, M Kurnaeva, R Eferl, D Stoiber, R Moriggl, M Bilban, AC Obenauf, C Ferran, B Dome, V Laszlo, B Györffy, K Dezso, J Moldvay, E Casanova, HP Moll

Science Translational Medicine (AAAS) Austria, USA, Hungary, 07 July 2021

Oncology, Pulmonology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

427
Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle

C Romagnoli, P Sharma, R Zonefrati, G Palmini, E Lucattelli, DT Ward, I Ellinger, M Innocenti, ML Brandi

International Journal of Molecular Sciences (MDPI) Italy, UK, Austria, 06 July 2021

Osteology

Key words: Skeletal Muscle, Satellite Cells, Myogenesis, Calcium-Sensing Receptor, G Protein-Coupled Receptors

Organism: Human

Tissue: Muscle

428
Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM

KEC Blokland, H Habibie, T Borghuis, GJ Teitsma, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess

Cells (MDPI) The Netherlands, Australia, Indonesia, Canada, 29 June 2021

Pulmonology

Key words: Extracellular Matrix, Senescence, Idiopathic Pulmonary Fibrosis, Proinflammatory, Profibrotic

Organism: Human

Cell Line: Primary human lung fibroblasts

429
Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma

J Xu, N Yu, P Zhao, F Wang, J Huang, Y Cui, H Ding, Y Yang, Y Gao, L Pan, H Chang, Y Wu, B Xiang, Y Gong, X Shuai, L Hou, L Xie, T Niu, T Liu, L Zhang, W Liu, W Zhang, Y Qu, W Lin, Y Zhu, S Zhao, Y Zheng

Frontiers in Oncology (Frontiers Media S.A.) China, 29 June 2021

Oncology

Key words: Extramedullary Multiple Myeloma, MIF, Immunohistochemistry Staining, Xenograft Models, Single-Cell Sequencing

Organism: Human

Tissue: Bone Marrow

Pathological State: Cancer

430
Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo

CC Ku, K Wuputra, K Kato, JB Pan, CP Li, MH Tsai, M Noguchi, Y Nakamura, CJ Liu, TF Chan, MF Hou, S Wakana, YC Wu, CS Lin, DC Wu, KK Yokoyama

Stem Cell Research & Therapy (BMC) Taiwan, Japan, 29 June 2021

Neuroscience

Key words: Antioxidation, Cerebellum, Granule Cells, Jun Dimerization Protein 2 (Jdp2), Reactive Oxygen Species (ROS)

Organism: Mouse

Tissue: Brain

431
Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy

YX Hong, WY Wu, F Song, C Wu, GR Li, Y Wang

Aging (Impact Journals) China, 27 June 2021

Cardiology

Key words: Cardiac Senescence, Telomere Length Shortening, Mitophagy, Sirt1, Sirt6, pAMPK

Organism: Mouse

Tissue: Heart

432
Inhibition of endoplasmic reticulum stress-related autophagy attenuates MCLR-induced apoptosis in zebrafish testis and mouse TM4 cells

Z Wu, F Wang, L Hu, J Zhang, D Chen, S Zhao

Ecotoxicology and Environmental Safety (Elsevier) China, 25 June 2021

Toxicology

Key words: MCLR, Autophagy, Endoplasmic Reticulum Stress, Apoptosis, Zebrafish

Organism: Zebrafish

Tissue: Testis

433
Magneto-Activation and Magnetic Resonance Imaging of Natural Killer Cells Labeled with Magnetic Nanocomplexes for the Treatment of Solid Tumors

T Sim, B Choi, SW Kwon, KS Kim, H Choi, A Ross, DH Kim

ACS NANO (ACS Publications) USA, 24 June 2021

Nanomedicine

Key words: Natural Killer Cell, Magneto-Activation, Nanocomplexes, Cell Labeling, Cancer Therapy

Organism: Rat

Tissue: Liver

Pathological State: Cancer

434
Omega-Class Glutathione Transferases of Carcinogenic Liver Fluke, Clonorchis sinensis, Modulate Apoptosis and Differentiation of Host Cholangiocytes

CS Ahn, JG Kim, I Kang, Y Kong

Antioxidants (MDPI) South Korea, 24 June 2021

Parasitology

Key words: Clonorchis Sinensis, Omega-Class Glutathione Transferase, Cholangiocyte, Oxidative Stress, Programmed Cell Death, Cell Differentiation, Protein Kinase, Gene Regulation

Organism: Rat

Tissue: Liver

Pathological State: Clonorchis sinensis Infection

435
Hematological consequences of malaria in mice previously treated for visceral leishmaniasis

GF Rani, H Ashwin, N Brown, IS Hitchcock, PM Kaye

Wellcome Open Research (Wellcome Open Research) UK, 18 June 2021

Parasitology

Key words: visceral leishmaniasis, malaria, mouse models, hematology, chemotherapy, coinfection

Organism: Mouse

Tissue: Liver

Pathological State: Leishmaniasis

436
Investigating Transcriptional Dynamics Changes and Time-Dependent Marker Gene Expression in the Early Period After Skeletal Muscle Injury in Rats

K Ren, L Wang, L Wang, Q Du, J Cao, Q Jin, G An, Na Li, L Dang, Y Tian, Y Wang, J Sun

Frontiers in Genetics (Frontiers Media S.A.) China, 17 June 2021

Genetics

Key words: Time-Series RNA-Seq, Gene Expression and Regulation Landscape, Time-Related Biomarkers, Transcriptional Dynamics, Skeletal Muscle Injury

Organism: Rat

Tissue: Muscle

Pathological State: Skeletal Muscle Injury

437
DNA polymerase β deficiency promotes the occurrence of esophageal precancerous lesions in mice

J Qin, Y Zhu, Y Ding, T Niu, Y Zhang, H Wu, L Zhu, B Yuan, Y Qiao, J Lu, K Liu, Z Dong, G Jin, X Chen, J Zhao

Neoplasia (Elsevier) China, 15 June 2021

Oncology

Key words: Polβ, NMBA, Esophageal Precancerous Lesion

Organism: Mouse

Tissue: Esophagus

Pathological State: Cancer

438
Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

H Mathsyaraja, J Catchpole, B Freie, E Eastwood, E Babaeva, M Geuenich, PF Cheng, J Ayers, M Yu, N Wu, S Moorthi, KR Poudel, A Koehne, W Grady, AM Houghton, AH Berger, Y Shiio, D MacPherson, RN Eisenman

eLife (eLife Sciences Publications) USA, 11 June 2021

Oncology

439
Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice

NR Rao, JN Savas

Journal of Proteome Research (ACS Publications) USA, 09 June 2021

Cell Biology

Key words: Mass Spectrometry, Peptides and Proteins, Central Nervous System, Rodent Models, Endocytosis

Organism: Mouse

Tissue: Brain

440
A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL‐40‐IL‐13 Receptor α2 Axis

Y van Sleen, WF Jiemy, S Pringle, KSM van der Geest, WH Abdulahad, M Sandovici, E Brouwer, P Heeringa, AMH Boots

Arthritis & Rheumatology (Wiley) The Netherlands, Malaysia, 08 June 2021

Rheumatology

Organism: Human

Cell Line: Human microvascular endothelial cells

441
A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer

SC Chang, CS Hung, BX Zhang, TH Hsieh, W Hsu, JL Ding

Cancers (MDPI) Taiwan, 08 June 2021

Oncology

Key words: CCNF, FBXL8, FZR1, RRM2, E3 Ubiquitin Ligase, Breast Cancer, Metastasis

Organism: Human

Cell Line: BRCA cells

442
Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma

SA O'Connor, HM Feldman, S Arora, P Hoellerbauer, CM Toledo, P Corrin, L Carter, M Kufeld, H Bolouri, R Basom, J Delrow, JL McFaline-Figueroa, C Trapnell, SM Pollard, A Patel, PJ Paddison, CL Plaisier

Molecular Systems Biology (EMBO press) USA, UK, 08 June 2021

Neuroscience

Organism: Human

Cell Line: U5-HNSCs

443
Determining optimal clinical target volume margins in high-grade glioma based on microscopic tumor extension and magnetic resonance imaging

S Nie, Y Zhu, J Yang, T Xin, S Xue, X Zhang, J Sun, D Mu, Y Gao, Z Chen, X Ding, J Yu, M Hu

Radiation Oncology (BMC) China, 07 June 2021

Oncology

Key words: High-Grade Glioma, Macropathology, Microscopic Extension, Predictive Model, Clinical Target Volume, Radiotherapy

Organism: Human

Tissue: Brain

Pathological State: Cancer

444
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer

W Liu, Y Wang, Y Xie, T Dai, M Fan, C Li, Y Zou

Cell Death Discovery (Nature) China, 05 June 2021

Oncology

Key words: Cancer Microenvironment

Organism: Mouse

Tissue: Ovaries

Pathological State: Cancer

445
Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment

O Nebie, K Carvalho, L Barro, L Delila, E Faivre, TY Renn, M-Li Chou, YW Wu, A Niem-Redene, SY Chou, L Buée, CJ Hu, Chih-Wei Peng, D Devos, D Blum, T Burnouf

Brain (Oxford Academic) Taiwan, France, 04 June 2021

Neuroscience

Key words: Human Platelet Lysate, Traumatic Brain Injury, Neuroprotection, Neurorestoration, Neurotrophins

Organism: Mouse

Tissue: Brain

Pathological State: Traumatic Brain Injury

446
MoNuSAC2020: A Multi-organ Nuclei Segmentation and Classification Challenge

R Verma, N Kumar, A Patil, NC Kurian, S Rane, S Graham, QD Vu, M Zwager, SEA Raza, N Rajpoot, X Wu, H Chen, Y Huang, L Wang, H Jung, GT Brown, Y Liu, S Liu, SAF Jahromi, AA Khani, E Montahaei, MS Baghshah, H Behroozi, P Semkin, A Rassadin, P Dutande, R Lodaya, U Baid, B Baheti, S Talbar, A Mahbod, R Ecker, I Ellinger, Z Luo, B Dong, Z Xu, Y Yao, S Lv, M Feng, K Xu, H Zunair, AB Hamza, S Smiley, TK Yin, QR Fang, S Srivastava, D Mahapatra, L Trnavska, H Zhang, PL Narayanan, J Law, Y Yuan, A Tejomay, A Mitkari, D Koka, V Ramachandra, L Kini, A Sethi

IEEE Transactions on Medical Imaging (IEEE Xplore) USA, Canada, India, The Netherlands, China, USA, China, Iran, Russia, Austria, Taiwan, UAE, Slovakia, UK, 04 June 2021

Medical Image Analysis

Key words: Multi-Organ Dataset, Nucleus Classification, Computational Pathology, Instance Segmentation, Panoptic Quality

447
Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice

KP Hammer, J Mustroph, T Stauber, W Birchmeier, S Wagner, LS Maier

PLoS One (PLOS) Germany, 04 June 2021

Physiology

Key words: Exercise, Running, Arrhythmia, Mouse Models, Heterozygosity, Phosphorylation, Physical Activity, Sedentary Behavior

Organism: Mouse

Tissue: Heart

448
Synthetic Fibrin-Derived Bβ15-42 Peptide Delays Thrombus Resolution in a Mouse Model

S Chausheva, B Redwan, S Sharma, N Marella, K Schlossleitner, AC Mueller, P Petzelbauer, T Morris, IM Lang

Arteriosclerosis, Thrombosis and Vascular Biology (American Heart Association) Austria, Germany, 03 June 2021

Cardiology

Key words: Macrophages, Microvessels, Monocyte, Plasma, Venous Thrombosis

Organism: Human

Cell Line: Dermal microvascular endothelial cells

449
Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study

CE Tiron, E Patrașcanu, PA Postu, IC Vacarean Trandafir, A Tiron, I Grigoras

Current Issues in Molecular Biology (MDPI) Romania, 02 June 2021

Oncology

Key words: AKT, Breast Cancer, EMT, HIF, Sevoflurane, Vimentin

Organism: Human

Pathological State: Cancer

Cell Line: MCF-10A cells

450
Lactate modulates cellular metabolism through histone lactylation-mediated gene expression in non-small cell lung cancer

J Jiang, DL Huang, Y Jiang, J Hou, MY Tian, JH Li, Li Sun, YG Zhang, T Zhang, ZQ Li, ZC Li, SX Tong

Frontiers in Oncology (Frontiers Media S.A.) China, 02 June 2021

Oncology

Key words: Lactate, Lactylation, Metabolism, Gene Expression, Non-Small Cell Lung Cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

451
Disruption of Tfh: B cell interactions prevents antibody-mediated rejection in a kidney transplant model in rats: impact of calcineurin inhibitor dose

L Steines, H Poth, A Schuster, K Amann, B Banas, T Bergler

Frontiers in Immunology (Frontiers Media S.A.) Germany, 31 May 2021

Transplantation Medicine

Key words: Antibody-Mediated Rejection, Donor-Specific Antibodies, Kidney Transplantation, T Follicular Helper Cells, B Cell Activation, Calcineurin Inhibitor

Organism: Rat

Tissue: Kidney

Pathological State: Organ Transplantation

452
Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation

JP Hohensinner, M Lenz, P Haider, J Mayer, M Richter, C Kaun, L Goederle, M Brekalo, M Salzmann, S Sharma, MB Fischer, S Stojkovic, D Ramsmayer, C Hengstenberg, BK Podesser, K Huber, CJ Binder, J Wojta, WS Speidl

Biochemical Pharmacology (Elsevier) Austria, 28 May 2021

Endocrinology

Organism: Mouse

Tissue: Blood Vessels

453
Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma

JY Chen, WH Cheng, KY Lee, HP Kuo, KF Chung, CL Chen, BC Chen, CH Lin

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, UK, 27 May 2021

Pulmonology

Key words: Chronic Obstructive Asthma, Airway Fibrosis, ADAM17, EGFR, Human Lung Fibroblasts

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

454
Investigating the Impact of the Bit Depth of Fluorescence-Stained Images on the Performance of Deep Learning-Based Nuclei Instance Segmentation

A Mahbod, G Schaefer, C Löw, G Dorffner, R Ecker, I Ellinger

Diagnostics (MDPI) Austria, UK, 27 May 2021

Medical Image Analysis

Key words: Bit Depth, Nuclei Segmentation, Fluorescence Staining, Medical Image Analysis, Computational Pathology, Deep Learning

455
Magneto Mitochondrial Dysfunction Mediated Cancer Cell Death Using Intracellular Magnetic Nano-Transducers

W Park, SJ Kim, P Cheresh, J Yun, B Lee, DW Kamp, DH Kim

Biomaterials Science (Royal Society of Chemistry) USA, South Korea, 26 May 2021

Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

456
Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection

WF Garcia-Beltran, DT Claiborne, CR Maldini, M Phelps, V Vrbanac, ME Karpel, KL Krupp, KA Power, CL Boutwell, AB Balazs, AM Tager, M Altfeld, TM Allen

Frontiers in Immunology (Frontiers Media S.A.) USA, Germany, 26 May 2021

Immunology

Key words: Innate Immunity, T Cells, HIV-1, HuBLT, BLT, Humanized Mice

Organism: Mouse

Tissue: Spleen, Thymus

Pathological State: HIV Infection

457
Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response

I Vargova, L Machova Urdzikova, K Karova, B Smejkalova, T Sursal, V Cimermanova, K Turnovcova, CD Gandhi, M Jhanwar-Uniyal, P Jendelova

Biomedicines (MDPI) Czech Republic, USA, 24 May 2021

Regenerative Medicine, Neuroscience

Key words: Spinal Cord Injury, mTOR, Rapamycin, pp242, Dual Inhibition, Autophagy, Inflammation

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

458
Remdesivir Alleviates Acute Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome

L Yin, H Zhao, H Zhang, Y Li, Y Dong, H Ju, F Kong, S Zhao

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 21 May 2021

Immunology, Pharmacology

Key words: Remdesivir, NLRP3 Inflammasome or NOD-, LRR-, Pyrin Domain-Containing Protein 3 (NLRP3)Inflammasome, NF-κB, Macrophage, Acute Kidney Injury

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

459
Evaluation of a Novel Tilapia-skin Acellular Dermis Matrix Rationally Processed for Enhanced Wound Healing

D Li, WQ Sun, T Wang, Y Gao, J Wu, Z Xie, J Zhao, C He, M Zhu, S Zhang, P Wang, X Mo

Materials Science and Engineering: C (Elsevier) China, 21 May 2021

Tissue Engineering

Key words: Tilapia Skin, Decellularization, Wound Healing, Degradation, Re-Epithelialization

Organism: Pig, Rat

Tissue: Skin

460
Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-Based Novel Therapy against Endotoxemia in Mice

HJ Shih, CY Chang, M Chiang, VL Le, HJ Hsu, CJ Huang

Journal of Personalized Medicine (MDPI) Taiwan, Vietnam, 20 May 2021

Pharmacology

Key words: TNF-α, IL-1β, IL-6, Necroptosis, Pyroptosis, Apoptosis, Liver

Organism: Mouse

Tissue: Liver

Pathological State: Endotoxemia

461
Piezo2 downregulation via the Cre-lox system affects aqueous humor dynamics in mice

J Fang, F Hou, S Wu, Y Liu, L Wang, J Zhang, N Wang, K Wang, W Zhu

Molecular Vision (Emory University) China, 20 May 2021

Ophthalmology

Organism: Human

Tissue: Eye

462
Tissue image cytometry

A Meshcheryakova, F Mungenast, R Ecker, D Mechtcheriakova

Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 1 (IOP Publishing) Austria, 15 May 2021

Medical Image Analysis

463
Modulation of the anticancer activities of paclitaxel by Cremophor micelles

JL Chiang, YW Yang

International Journal of Pharmaceutics (Elsevier) Taiwan, 14 May 2021

Oncology

Key words: Cell Cycle, Cremophor, Micelle, Paclitaxel, Polyploidy

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

464
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo

YW Wu, MW Chao, HJ Tu, LC Chen, KC Hsu, JP Liou, CR Yang, SC Yen, WC HuangFu, SL Pan

Oncogenesis (Nature) Taiwan, China, 13 May 2021

Oncology

Key words: Drug Development, Drug Discovery and Development

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

465
Machine-perfused donor kidneys as a source of human renal endothelial cells

RGM Lammerts, LM Lagendijk, G Tiller, WA Dam, HL Lancaster, MR Daha, MA Seelen, BG Hepkema, RA Pol, HGD Leuvenink, G Molema, J van den Born, SP Berger

American Journal of Physiology (APS Journals) The Netherlands, 11 May 2021

Nephrology

Key words: Donation, Endothelial Cells, Kidney, Machine Perfusion, Perfusate, Transplantation

Organism: Human

Pathological State: Organ Transplantation

Cell Line: Cells derived from machine perfusates after kidney donation

466
Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures

YJ Wu, ME Chien, CC Chiang, YZ Huang, DM Durand, KS Hsu

Brain Stimulation (Elsevier) Taiwan, USA, 11 May 2021

Neuroscience

Key words: Seizure, Epilepsy, Electroencephalography (EEG), Oscillation, Interictal Spikes, Transcranial Direct Current Stimulation (tDCS)

Organism: Rat

Tissue: Brain

Pathological State: Chronic Seizures

467
Intravital mesoscopic fluorescence molecular tomography allows non-invasive in vivo monitoring and quantification of breast cancer growth dynamics

MS Ozturk, MG Montero, L Wang, LM Chaible, M Jechlinger, R Prevedel

Communications Biology (Nature) Turkey, Germany, 11 May 2021

Oncology

Key words: 3-D Reconstruction, Fluorescence Imaging, Molecular Imaging, Optical Imaging, Time-Lapse Imaging

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

468
Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase

W Mai, L Kong, H Yu, J Bao, C Song, G Qu

Bioscience Reports (Portland Press) China, 10 May 2021

Oncology

Key words: Human Osteosarcoma, Metastasis, Glycogen Synthase Kinase 3β

Organism: Human

Tissue: Bone

Pathological State: Cancer

469
Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation

J Kim, Y Moon

Communications Biology (Nature) South Korea, 10 May 2021

Oncology

Key words: Cancer Microenvironment, Pharmacodynamics

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

470
Dystrophin Deficiency Causes Progressive Depletion of Cardiovascular Progenitor Cells in the Heart

S Jelinkova, Y Sleiman, P Fojtík, F Aimond, A Finan, G Hugon, V Scheuermann, D Beckerova, O Cazorla, M Vincenti, P Amedro, S Richard, J Jaros, P Dvorak, A Lacampagne, G Carnac, V Rotrekl, AC Meli

International Journal of Molecular Sciences (MDPI) Czech Republic, France, 10 May 2021

Cardiology

Key words: Duchenne Muscular Dystrophy, mdx Mouse, Cardiovascular Progenitors, C-Kit, Genomic Instability, Dilated Cardiomyopathy

Organism: Mouse

Tissue: Heart

471
Neutralizing Anti-Interleukin-1 Receptor-Antagonist Autoantibodies Induce Inflammatory and Fibrotic Mediators in IgG4-Related Disease

JA Jarrell, MC Baker, CA Perugino, H Liu, MS Bloom, T Maehara, HH Wong, Tobias Lanz, JZ Adamska, S Kongpachith, J Sokolove, JH Stone, SS Pillai, WH Robinson

Journal of Allergy and Clinical Immunology (Elsevier) USA, Germany, 08 May 2021

Immunology

Key words: IL-1 Receptor-Antagonist (IL1-RA), IgG4-RD (IgG4-RD), Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), Multiple Sclerosis (MS), Immunoglobulin (Ig)

Organism: Human

Pathological State: Multiple Sclerosis

472
Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway

T Zhu, L Wang, W Xie, X Meng, Y Feng, G Sun, X Sun

Frontiers in Pharmacology (Frontiers Media S.A.) China, 07 May 2021

Pharmacology, Neuroscience

Key words: Ischemic Stroke, Notoginsenoside R1, Neurogenesis, Neurological Recovery, Oligodendrogenesis

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia, Reperfusion Injury

473
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice

YL Wang, YH Lee, YH Hsu, IJ Chiu, CCY Huang, CC Huang, ZC Chia, CP Lee, YF Lin, HW Chiu

Environmental Health Perspectives (National Institute of Environmental Health Sciences) Taiwan, 06 May 2021

Toxicology,Nephrology

Organism: Human

Cell Line: HK-2 cells

474
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration

O Guillermin, N Angelis, CM Sidor, R Ridgway, A Baulies, A Kucharska, P Antas, MR Rose, J Cordero, O Sansom, VSW Li, BJ Thompson

EMBO Journal (EMBO press) UK, Australia, 05 May 2021

Regenerative Medicine

Organism: Mouse

Tissue: Small Intestine

475
In Situ Maturated Early-Stage Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improve Cardiac Function by Enhancing Segmental Contraction in Infarcted Rats

D Biagi, ET Fantozzi, JC Campos-Oliveira, MV Naghetini, AF Ribeiro Jr, S Rodrigues, I Ogusuku, R Vanderlinde, M Lopes Araújo Christie, D Bastos Mello, AC Campos de Carvalho, M Valadares, E Cruvinel, R Dariolli

Journal of Personalized Medicine (MDPI) Brazil, Germany, USA, 04 May 2021

Cardiology, Stem Cell Research

Key words: Stem Cell-Therapy, Human Induced Pluripotent Stem Cells, Cardiomyocytes, Myocardial Infarction, Heart Failure, Regeneration, Cardiac Function

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Infarction

476
Effects of inverted photoperiods on the blood pressure and carotid artery of spontaneously hypertensive rats and Wistar–Kyoto rats

YL Wang, T Zhang, YG Zhang, Y Yu, F Bai, H Zhang, YF Chi

Journal of Hypertension (LWW Journals) China, 01 May 2021

Cardiology

Key words: Arterial Thrombosis, Atherosclerosis, Hypertension, Inverted Photoperiod

Organism: Rat

Tissue: Blood Vessels

Pathological State: Atherosclerosis, Hypertension

477
CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation

R Ajoy, YC Lo, MH Ho, YY Chen, Y Wang, YH Chen, C Jing-Yuan, CA Changou, YC Hsiung, HM Chen, TH Chang, CY Lee, YH Chiang, WC Chang, B Hoffer, SY Chou

Molecular Psychiatry (Nature) Taiwan, USA, 30 April 2021

Neuroscience

Key words: Neuroscience, Physiology

Organism: Mouse

Tissue: Brain

478
Development of a mechanically matched Silk Scaffolded 3D clear cell renal cell carcinoma model

A Abbott, K Bond, T Chiba, S Sims-Lucas, L Oxburgh, JM Coburn

Materials Science and Engineering: C (Elsevier) USA, 29 April 2021

Biological Materials

Key words: Scaffold, Mechanical Testing, Tissue Engineering, Cancer Modeling

Organism: Human

Tissue: Kidney

Pathological State: Cancer

479
Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction

M Muhuri, W Zhan, Y Maeda, J Li, A Lotun, J Chen, K Sylvia, I Dasgupta, M Arjomandnejad, T Nixon, AM Keeler, S Manokaran, R He, Q Su, PWL Tai, G Gao

Frontiers in Immunology (Frontiers Media S.A.) USA, 28 April 2021

Virology

Key words: Adeno-Associated Virus Vectors, microRNA, miR-BS, miR-142, miR-652-5p, miR-223-3p, Antigen Presenting Cells, Gene Therapy

Organism: Mouse

Tissue: Muscle

480
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

JH Choe, PB Watchmaker, MS Simic, RD Gilbert, AW Li, NA Krasnow, KM Downey, W Yu, DA Carrera, A Celli, J Cho, JD Briones, JM Duecker, YE Goretsky, R Dannenfelser, L Cardarelli, O Troyanskaya, SS Sidhu, KT Roybal, H Okada, WA Lim

Science Translational Medicine (AAAS) USA, Canada, 28 April 2021

Oncology

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

481
Minoxidil-coated lysozyme-shelled microbubbes combined with ultrasound for the enhancement of hair follicle growth: Efficacy in vitro and in vivo

AH Liao, YJ Huang, HC Chuang, CH Wang, CP Shih, CP Chiang

Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan, 27 April 2021

Pharmacology

Key words: Ultrasound, Cavitation, Lysozyme-Shelled Microbubbles, Minoxidil, Hair Follicle

Organism: Mouse

Tissue: Skin

482
Macrophages Inhibit Ciliary Protein Levels by Secreting BMP-2 Leading to Airway Epithelial Remodeling Under Cigarette Smoke Exposure

Z Wang, W Liang, C Ma, J Wang, X Gao, L Wie

Frontiers in Molecular Biosciences (Frontiers Media S.A.) China, 26 April 2021

Cell Biology

Key words: COPD, Cigarette Smoking, Macrophage, Bronchial Epithelial Cell, Ciliary Protein

Organism: Mouse

Tissue: Lung

483
Cells in the gut

T Skrzypek, K Ferenc, M Domino, J Olszewski, R Zabielski

Atlas of the Pig Gut (Elsevier) Poland, 23 April 2021

Gastroenterology

Key words: Stem Cells, Enterocytes, Goblet Cells, Enteroendocrine Cells, M Cells, Tuft Cells, Interstitial Cells of Cajal, Myocytes

484
Magnetic Fluid Hyperthermia as Treatment Option for Pancreatic Cancer Cells and Pancreatic Cancer Organoids

J Palzer, B Mues, R Goerg, M Aberle, SS Rensen, SWM Olde Damink, RDW Vaes, T Cramer, T Schmitz-Rode, UP Neumann, I Slabu, AA Roeth

International Journal of Nanomedicine (Dovepress) Germany, The Netherlands, 23 April 2021

Nanomedicine, Oncology

Key words: Magnetic Nanoparticles, SPION, Pancreatic Cancer, PDAC, Organoids, Magnetic Fluid Hyperthermia

Organism: Human

Pathological State: Cancer

Cell Line: PaCa-2 cells, PANC-1 cells

485
Augmentation of the insufficient tissue bed for surgical repair of hypospadias using acellular matrix grafts: A proof of concept study

D Morgante, A Radford, SK Abbas, E Ingham, R Subramaniam, J Southgate

Journal of Tissue Engineering (SAGE Journals) UK, 20 April 2021

Tissue Engineering

Key words: Acellular Matrix, Biomaterial, Surgery, Hypospadias Repair, Tissue Integration

Organism: Pig

Tissue: Penis

Pathological State: Hypospadias

486
Exposure-time-dependent subcellular staging of gold nanoparticles deposition and vesicle destruction in mice livers

XM Wang, XW Wu, XY Zhao, CW Wang, JN Zhou

Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier) China, 20 April 2021

Nanomedicine

Key words: Gold Nanoparticles, Biodistribution, Liver, Vesicle, Transmission Electron Microscopy

Organism: Mouse

Tissue: Liver

487
Cardiac Protection by Oral Sodium Thiosulfate in a Rat Model of L-NNA-Induced Heart Disease

ITN Nguyen, LM Wiggenhauser, M Bulthuis, JL Hillebrands, M Feelisch, MC Verhaar, H van Goor, JA Joles

Frontiers in Pharmacology (Frontiers Media S.A.) The Netherlands, UK, 15 April 2021

Pharmacology

Key words: Hydrogen Sulfide, Hypertension, ACE-Inhibitor, Cardiovascular Disease, Nitric Oxide

Organism: Rat

Tissue: Heart

Pathological State: Hypertension, Heart Disease

488
Contribution of Genetic Background to the Radiation Risk for Cancer and Non-Cancer Diseases in Ptch1+/–Mice

I De Stefano, S Leonardi, A Casciati, E Pasquali, P Giardullo, F Antonelli, F Novelli, G Babini, M Tanori, B Tanno, A Saran, M Mancuso, S Pazzaglia

Radiation Research (Radiation Research Society) Italy, 15 April 2021

Oncology

489
Persistent expression of interleukin‐17 and downstream effector cytokines in recalcitrant psoriatic lesions after ustekinumab treatment

BR Kim, M Kim, S Yang, CW Choi, KS Lee, SW Youn

The Journal of Dermatology (Wiley) South Korea, 15 April 2021

Dermatology

Key words: Cytokines, Interleukin‐17, Interleukin‐23, Psoriasis, Ustekinumab

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

490
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages

J Lv, Z Wang, Y Qu, H Zhu, Q Zhu, W Tong, L Bao, Q Lv, J Cong, D Li, W Deng, P Yu, J Song, WM Tong, J Liu, Y Liu, C Qin, B Huang

Cell discovery (Nature) China, 13 April 2021

SARS-CoV-2

Key words: Innate Immunity, Mechanisms of Disease

Organism: Mouse

Tissue: Lung

Pathological State: Covid-19

491
Enhancing Anti-Tumoral Potential of CD-NHF by Modulating PI3K/Akt Axis in U87 Ex Vivo Glioma Model

G Luta, M Butura, A Tiron, CE Tiron

International Journal of Molecular Sciences (MDPI) Romania, 08 April 2021

Oncology

Key words: Glioblastoma, Anti-Cancer Agent, Carbon Dots, EMT, Nanomedicine

Organism: Human

Cell Line: U87 cells

492
Next-Generation Digital Histopathology of the Tumor Microenvironment

F Mungenast, A Fernando, R Nica, B Boghiu, B Lungu, J Batra, RC Ecker

Genes (MDPI) Austria, Australia, Romania, 07 April 2021

Medical Image Analysis

Key words: Next-Generation Digital Histopathology, Tissue Cytometry, Multiplexing, RNA ISH, Cancer, Tumor Immune Microenvironment, Tumor Microenvironment

493
Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer

SH Park, K Fong, J Kim, F Wang, X Lu, Y Lee, LT Brea, K Wadosky, C Guo, SA Abdulkadir, JD Crispino, D Fang, P Ntziachristos, X Liu, X Li, Y Wan, DW Goodrich, JC Zhao, J Yu

Science Advances (AAAS) USA, 07 April 2021

Oncology

Organism: Human

Tissue: Prostate

Pathological State: Cancer

494
Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model

MA Plantz, S Minardi, JG Lyons, AC Greene, DJ Ellenbogen, M Hallman, JT Yamaguchi, S Jeong, C Yun, AE Jakus, KR Blank, RM Havey, M Muriuki, AG Patwardhan, RN Shah, WK Hsu, SR Stock, EL Hsu

Acta Biomaterialia (Elsevier) USA, 06 April 2021

Biological Materials

Key words: 3D Printing, Hydroxyapatite, Demineralized Bone Matrix, Bone Regeneration, Spine Fusion

Organism: Rat

Tissue: Spinal Cord

495
Therapeutic effect of modulating the NLRP3-regulated transforming growth factor-β signaling pathway on interstitial cystitis/bladder pain syndrome

HJ Shih, CY Chang, CH Lai, CJ Huang

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 01 April 2021

Pharmacology

Key words: Inflammation, Bladder, Inflammasome, Curcumin, Fibrosis

Organism: Mouse

Tissue: Bladder

Pathological State: Interstitial cystitis, Bladder pain syndrome

496
Human skin aging is associated with increased expression of the histone variant H2A. J in the epidermis

CE Rübe, C Bäumert, N Schuler, A Isermann, Z Schmal, M Glanemann, C Mann, H Scherthan

npj Aging and Mechanisms of Disease (Nature) Germany, France, 01 April 2021

Aging

Key words: Aging, Epigenetics

Organism: Mouse

Tissue: Skin

497
Single-cell sequencing reveals the transcriptome and TCR characteristics of pTregs and in vitro expanded iTregs

Z Hui, J Zhang, Y Zheng, L Yang, W Yu, Y An, F Wie, Y Ren

Frontiers in Immunology (Frontiers Media S.A.) China, 31 March 2021

Immunology

Key words: Single-Cell Sequencing, In Vitro, Regulatory T Cells, Colorectal Cancer, Chemokine Receptors

Organism: Human

Tissue: Colon

Pathological State: Cancer

498
Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen

A Dievernich, P Achenbach, L Davies, U Klinge

Hernia (Springer) Germany, UK, 31 March 2021

Immunology, Tissue Engineering

Key words: Foreign Body Reaction, Adaptive Immune System, Innate Immune System, Mesh, Fluorescence Microscopy

Organism: Human

Pathological State: Abdominal wall hernia

499
n-Butyl Benzyl Phthalate Exposure Promotes Lesion Survival in a Murine Endometriosis Model

P Sharma, JYL Lee, EM Tsai, Y Chang, JJ Suen

International Journal of Environmental Research and Public Health (MDPI) Taiwan, 31 March 2021

Reproductive Medicine

Key words: N-Butyl Benzyl Phthalate, CD44, Dendritic Cell, Endometriosis

Organism: Mouse

Tissue: Endometrium

Pathological State: Endometriosis

500
Therapeutic Effect of Cinnamomum osmophloeum Leaf Extract on Oral Mucositis Model Rats Induced by 5-Fluororacil via Influencing IL-1β and IL-6 Levels

A Bakar, V Ningrum, SC Lee, CT Li, CW Hsieh, SH Wang, MS Tsai

Processes (MDPI) Indonesia, Taiwan, 31 March 2021

Pharmacology

Key words: Cinnamomum Osmophloeum, Oral Mucositis, Model Rat, 5-Fluororacil, IL-1β, IL-6

Organism: Rat

Tissue: Mucosa

Pathological State: Oral Mucositis

501
Hypoxia and oxidative stress induce sterile placental inflammation in vitro

BC Baker, AEP Heazell, C Sibley, R Wright, H Bischof, F Beards, T Guevara, S Girard, RL Jones

Scientific Reports (Nature) UK, Canada, 31 March 2021

Reproductive Medicine

Key words: Developmental Biology, Diseases, Immunology, Medical Research, Pathogenesis

Organism: Mouse

Tissue: Placenta

Pathological State: Placental inflammation

502
Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

M Delacher, M Simon, L Sanderink, A Hotz-Wagenblatt, M Wuttke, K Schambeck, L Schmidleithner, S Bittner, A Pant, U Ritter, T Hehlgans, D Riegel, V Schneider, FK Groeber-Becker, A Eigenberger, C Gebhard, N Strieder, A Fischer, M Rehli, P Hoffmann, M Edinger, T Strowig, J Huehn, C Schmidl, JM Werner, L Prantl, B Brors, CD Imbusch, M Feuerer

Immunity (Cell Press) Germany, 30 March 2021

Immunology

Organism: Human

Tissue: Skin

503
Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia

O Nonn, C Fischer, S Geisberger, A El-Heliebi, T Kroneis, D Forstner, G Desoye, AC Staff, M Sugulle, R Dechend, U Pecks, M Kollmann, C Stern, JE Cartwright, GS Whitley, B Thilaganathn, C Wadsack, B Huppertz, F Herse, M Gauster

Hypertension (American Heart Association) Austria, Germany, Norway, UK, 29 March 2021

Reproductive Medicine

Key words: Candesartan, Leptin, Oxygen, Respiration, Trophoblasts

Organism: Human

Tissue: Placenta

504
Expression of CD9 on porcine lymphocytes and its relation to T cell differentiation and cytokine production

JV Milburn, A Hoog, S Winkler, KA van Dongen, J Leitner, M Patzl, A Saalmüller, K de Luca, P Steinberger, KH Mair, W Gerner

Developmental & Comparative Immunology (Elsevier) Austria, France, 27 March 2021

Immunology

Key words: Tetraspanin, CD9, Porcine, Lymphocyte, Memory

Organism: Mouse

Tissue: Lymphoid Tissue

505
Selective Denervation of the Facial Dermato-Muscular Complex in the Rat: Experimental Model and Anatomical Basis

V Tereshenko, DC Dotzauer, U Maierhofer, C Festin, M Luft, G Laengle, O Politikou, HJ Klein, R Blumer, OC Aszmann, KD Bergmeister

Frontiers in Neuroanatomy (Frontiers Media S.A.) Austria, Switzerland, 22 March 2021

Neuroscience

Key words: Facial Nerve, Trigeminal Nerve, Motor-Sensory Control, Facial Muscles, Axon Quantification, Whole-Mount Staining

Organism: Rat

Tissue: Nerves

506
Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia

L Morales-Nebreda, KA Helmin, MAT Acosta, NS Markov, JY Hu, AM Joudi, R Piseaux-Aillon, H Abdala-Valencia, Y Politanska, BD Singer

JCI Insight (The American Society for Clinical Investigation) USA, 22 March 2021

Aging

Key words: Aging, T Cells

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection, Pneumonia

507
Inhibition of vascular adhesion protein‐1 enhances the anti‐tumor effects of immune checkpoint inhibitors

T Kinoshita, MA Sayem, T Yaguchi, B Kharma, K Morii, D Kato, S Ohta, Y Mashima, H Asamura, Y Kawakami

Cancer Science (Japanese Cancer Association) Japan, Bangladesh, 18 March 2021

Oncology

Key words: CTLs, H2O2, ICIs, Immunosuppression, VAP‐1 Inhibitor

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

508
Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis

W Cui, D Liu, W Gu, B Chu

Cell Death & Differentiation (Nature) China, USA, 17 March 2021

Oncology

Key words: Cancer Metabolism, Phospholipids

Organism: Human

Tissue: Kidney

Pathological State: Cancer

509
Luteolin Modulates the NF-E2-Related Factor 2/Glutamate–Cysteine Ligase Pathway in Rats with Spinal Cord Injury

J Fu, W Xu, Y Zhang, H Sun, J Zhao

Journal of Medicinal Food (Mary Ann Liebert Inc.) China, 16 March 2021

Neuroscience

Key words: Luteolin, Nrf2/GCL Pathway, Oxidative Stress, Spinal Cord Injury

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

510
Machine perfused donor kidneys as a source of human renal endothelial cells

RGM Lammerts, LM Lagendijk, G Tiller, WA Dam, HL Lancaster, MR Daha, MA Seelen, BG Hepkema, RA Pol, HGD Leuvenink, G Molema, J van den Born, SP Berger, the COMBAT Consortium

American Journal of Physiology (APS Journals) The Netherlands, 15 March 2021

Nephrology

Key words: Kidney, Transplantation, Endothelial Cells, Machine Perfusion, Perfusate

Organism: Human

Pathological State: Organ Transplantation

Cell Line: MP-PRECs

511
Genetic Drivers of Head and Neck Squamous Cell Carcinoma: Aberrant Splicing Events, Mutational Burden, HPV Infection and Future Targets

Z Dlamini, M Alaouna, S Mbatha, A Bhayat, M Mabongo, A Chatziioannou, R Hull

Genes (MDPI) South Africa, Greece, 15 March 2021

Oncology

Key words: Head and Neck Squamous Cell Carcinoma (HNSCC), Aberrant Splicing Events, Human Papillomavirus (HPV) Infection, Non-Coding RNA (ncRNA), Methylation, Mutational Burden

Pathological State: Cancer, HPV Infection

512
A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice

HL Lee, SW Hee, CF Hsuan, W Yang, JY Huang, YL Lin, CN Hsu, JJ Hwang, SM Chen, ZZ Ding, TY Lee, YC Lin, FC Tsai, WL Su, LY Chueh, ML Hsieh, CH Chen, D Mochly-Rosen, YC Chang, LM Chuang

Antioxidants (MDPI) Taiwan, USA, 13 March 2021

Cardiology, Endocrinology

Key words: Diabetic Cardiomyopathy, 4-Hydroxy-2-Nonenal, Mitochondrial Aldehyde Dehydrogenase 2, AD-9308

Organism: Mouse

Tissue: Heart

Pathological State: Diabetes

513
MicroRNA-126 inhibits pathological retinal neovascularization via suppressing vascular endothelial growth factor expression in a rat model of retinopathy of prematurity

YY Fan, CH Liu, AL Wu, HC Chen, YJ Hsueh, KJ Chen, CC Lai, CY Huang, WC Wu

European Journal of Pharmacology (Elsevier) Taiwan, 13 March 2021

Pharmacology

Key words: miR-126, Retinal Pigment Epithelium Cells, Vascular Endothelial Growth Factor, Oxygen-Induced Retinopathy, Neovascularization, Rat

Organism: Rat

Tissue: Eye

Pathological State: Retinopathy

514
N-Acetyl Cysteine Overdose Inducing Hepatic Steatosis and Systemic Inflammation in Both Propacetamol-Induced Hepatotoxic and Normal Mice

GG Liou, CC Hsieh, YJ Lee, PH Li, MS Tsai, CT Li, SH Wang

Antioxidants (MDPI) Taiwan, 12 March 2021

Hepathology

Key words: Acetaminophen Overdose, N-Acetyl Cysteine Overdose, Two Inbred Mouse Strains, Hepatic Inflammation, Systemic Inflammation, Microvesicular Steatosis

Organism: Mouse

Tissue: Liver

Pathological State: Hepatic Steatosis, Systemic Inflammation

515
Dissecting pathways to thrombocytopenia in a mouse model of visceral leishmaniasis

GF Rani, O Preham, H Ashwin, N Brown, IS Hitchcock, PM Kaye

Blood Advances (ASH Publications) UK, 12 March 2021

Immunology

Key words: Blood Platelets, Infections, Leishmania Donovani, Leishmaniasis, Visceral, Mice, Thrombocytopenia, Drug Clearance, Thrombopoietin, Spleen, Liver

Organism: Mouse

Tissue: Liver

Pathological State: Leishmaniasis

516
CHPF Regulates the Aggressive Phenotypes of Hepatocellular Carcinoma Cells via the Modulation of the Decorin and TGF-β Pathways

CH Liu, BR Wu, YJ Ho, YH Chu, WC Hsu, TJ Tseng, JP Li, WC Liao

Cancers (MDPI) Taiwan, 12 March 2021

Oncology

Key words: Hepatocellular Carcinoma, Tumor Microenvironment, Chondroitin Polymerizing Factor, Chondroitin Sulfate, Decorin

Organism: Human

Tissue: Liver

Pathological State: Cancer

517
KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma

J Ingruber, D Savic, TB Steinbichler, S Sprung, F Fleischer, R Glueckert, G Schweigl, II Skvortsova, H Riechelmann, J Dudás

Cells (MDPI) Austria, 12 March 2021

Oncology

Key words: TissueFaxs, TWIST, ZEB, SCC-25, FaDu, UPCI-SCC090

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

518
Dietary Modification Alters the Intrarenal Immunologic Micromilieu and Susceptibility to Ischemic Acute Kidney Injury

J Jeon, K Lee, KE Yang, JE Lee, GY Kwon, W Huh, DJ Kim, YG Kim, HR Jang

Frontiers in Immunology (Frontiers Media S.A.) South Korea, 11 March 2021

Immunology, Nephrology

Key words: Diet, High-Salt Diet, High-Fat Diet, Acute Kidney Injury, Immunologic Micromilieu, Ischemia-Reperfusion Injury

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

519
Genome-wide 5-hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer

SL Wu, X Zhang, M Chang, C Huang, J Qian, Q Li, F Yuan, L Sun, X Yu, X Cui, J Jiang, M Cui, Y Liu, HW Wu, ZYLiang, X Wang, Y Niu, WM Tong, F jin

Genomics, Proteomics & Bioinformatics (Elsevier) China, 11 March 2021

Proteomics, Oncology

Key words: 5-Hydroxymethylcytosine (5hmC), Breast Cancer, Lymph Node Metastasis, MAP7D1, Biomarker

Organism: Human

Tissue: Breast, Lymphoid Tissue

Pathological State: Cancer

520
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma

P Kumthekar, CH Ko, T Paunesku, K Dixit, AM Sonabend, O Bloch, M Tate, M Schwartz, L Zuckerman, R Lezon, RV Lukas, B Jovanovic, K McCortney, H Colman, S Chen, B Lai, O Antipova, J Deng, L Li, S Tommasini-Ghelfi, LA Hurley, D Unruh, NV Sharma, M Kandpal, FM Kouri, RV Davuluri, DJ Brat, M Muzzio, M Glass, V Vijayakumar, J Heidel, FJ Giles, AK Adams, CD James, GE Woloschak, C Horbinski, AH Stegh

Science Translational Medicine (AAAS) USA, 10 March 2021

Oncology

Organism: Human

Tissue: Brain

Pathological State: Cancer

521
Aurka loss in CD19+ B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production

X Chen, C Wang, N Sun, S Pan, R Li, X Li, J Zhao, H Tong, Y Tang, J Han, J Qiao, H Qiu, H Wang, J Yang, T Ikezoe

Theranostics (Ivyspring International Publisher) China, Japan, 04 March 2021

Cell Biology

Key words: Aurora-A, Thrombopoietin, STAT3, IL-6, Megakaryocytopoiesis.

Organism: Mouse

Tissue: Spleen

522
CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment

WC Liao, HR Yen, CH Chen, YH Chu, YC Song, TJ Tseng, CH Liu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, 01 March 2021

Oncology

Key words: Breast Cancer, Chondroitin Sulfate, CHPF, Tumor Microenvironment, Syndecan-4

Organism: Human

Tissue: Breast

Pathological State: Cancer

523
Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury

S Yang, T Hu, H Liu, Y Lv, W Zhang, H Li, L Xuan, LL Gong, LH Liu

Biomedicine & Pharmacotherapy (Elsevier) China, USA, 27 February 2021

Gastroenterology

Organism: Mouse

Tissue: Small Intestine

524
Parathyroid hormone induces transition of myofibroblasts in arteriovenous fistula and increases maturation failure

CT Liu, SC Hsu, HL Hsieh, CH Chen, CY Chen, YM Sue, FY Lin, CM Shih, YT Shiu, PH Huang

Endocrinology (Oxford Academic) Taiwan, USA, 26 February 2021

Endocrinology

Key words: Arteriovenous Fistula (AVF), Fibrosis, Hemodialysis, Parathyroid Hormone (PTH)

Organism: Mouse

Tissue: Peritoneum, Muscle

525
Gastric Enzyme Supplementation Inhibits Food Allergy in a BALB/c Mouse Model

N Samadi, D Heiden, M Klems, M Salzmann, J Rohrhofer, E Weidmann, L Koidl, E Jensen-Jarolim, E Untersmayr

Nutrients (MDPI) Austria, 26 February 2021

Allergy Research

Key words: Food Allergy, Gastric Enzymes, Gastric Acid Suppression, Systemic Allergic Response, Allergy Prevention

Organism: Mouse

Tissue: Stomach

526
Genetic Background Effects on the Expression of an Odorant Receptor Gene

AG Leme Silva, MH Nagai, TS Nakahara, B Malnic

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) Brazil, 25 February 2021

Neuroscience

Key words: DNA Methylation, Odorant Receptor Gene, Olfactory Receptor Gene, Genetic Background, Gene Expression, Single Nucleotide Polymorphism

Organism: Mouse

Tissue: Nose

527
Regulation of pancreatic fibrosis by acinar cell-derived exosomal miR-130a-3p via targeting of stellate cell PPAR-γ

Q Wang, H Wang, Q Jing, Y Yang, D Xue, C Hao, W Zhang

Journal of Inflammation Research (Dovepress) China, 24 February 2021

Gastroenterology

Key words: Pancreatitis, Exosomes, miR-130a-3p, Pancreatic Fibrosis, PPAR- γ

Organism: Rat

Tissue: Pancreas

Pathological State: Pancreatitis

528
Pollen grain microscopic image classification using an ensemble of fine-tuned deep convolutional neural networks

A Mahbod, G Schaefer, R Ecker, I Ellinger

International Conference on Pattern Recognition (Springer) Austria, UK, 21 February 2021

Machine Learning

Key words: Medical Image Analysis

529
Accuracy of HPV E6/E7 mRNA examination using in situ hybridization in diagnosing cervical intraepithelial lesions

C Hui, H Bai, J Liu, X Lu, S Wang, Z Zhang, M Jin, Y Wang, Y Liu

Diagnostic Pathology (Springer) China, 19 February 2021

Pathology

Key words: Cervical Intraepithelial Neoplasia, CIN, Diagnostic Accuracy, E6/E7 mRNA, In Situ Hybridization

Organism: Human

Tissue: Cervix

Pathological State: Cervical lesions

530
T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells

Abigail E Schiff, Alice H Linder, Shillah N Luhembo, Stephanie Banning, Martin J Deymier, Thomas J Diefenbach, Amy K Dickey, Athe M Tsibris, Alejandro B Balazs, Josalyn L Cho, Benjamin D Medoff, Gerhard Walzl, Robert J Wilkinson, Wendy A Burgers, Björn Corleis, Douglas S Kwon

Scientific Reports (Nature) USA, South Africa, UK, Germany, 16 February 2021

Virology

Key words: HIV Infections, Monocytes and Macrophages, Mucosal Immunology, Retrovirus, Virology, Virus–Host Interactions

Organism: Human

Tissue: Lung

Pathological State: HIV infection

531
Imbalance of TGF-β1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness

J Ning, Y Ye, D Bu, G Zhao, T Song, P Liu, W Yu, H Wang, H Li, X Ren, G Ying, Y Zhao, J Yu

Molecular Therapy (Elsevier) China, 15 February 2021

Oncology

Organism: Human

Tissue: Liver

Pathological State: Cancer

532
Curcumin inhibits the growth of liver cancer by impairing myeloid‑derived suppressor cells in murine tumor tissues

S Tian, L Liao, Q Zhou, X Huang, P Zheng, Y Guo, T Deng, X Tian

Oncology Letters (Spandidos Publications) China, 12 February 2021

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

533
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4

T Guo, YH Bai, XJ Cheng, HB Han, H Du, Y Hu, SQ Jia, XF Xing, JF Ji

Cancer Communications (Wiley) China, 11 February 2021

Oncology

Key words: Gastric Cancer, Glucose Transporter 4, Glycolysis, Insulin Gene Enhancer Protein 1, Tumorigenesis

Organism: Human

Tissue: Stomach

Pathological State: Cancer

534
Global Analysis of Lysine Acetylome Reveals the potential role of CCL18 in non‐small cell lung cancer

S Kong, L Ding, C Fan, Y Li, C Wang, K Wang, W Xu, X Shi, Q Wu, F Wang

Proteomics (Wiley) China, 11 February 2021

Proteomics

Key words: Acetylome, CCL18, Non-Small Cell Lung Cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

535
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms

Wolf Eilenberg, Branislav Zagrapan, Sonja Bleichert, Nahla Ibrahim, Viktoria Knöbl, Annika Brandau, Luca Martelanz, Marie-Therese Grasl, Hubert Hayden, Paimann Nawrozi, Renata Rajic, Charlotte Häusler, Alexandros Potolidis, Nawa Schirwani, Andreas Scheuba, Johannes Klopf, Peter Teubenbacher, Markus P Weigl, Patrick Kirchweger, Dietrich Beitzke, Alexander Stiglbauer-Tscholakoff, Adelheid Panzenböck, Irene Lang, Lisa-Marie Mauracher, Lena Hell, Ingrid Pabinger, Marc A Bailey, D Julian A Scott, Lars Maegdefessel, Albert Busch, Ihor Huk, Christoph Neumayer, Christine Brostjan

Translational Research (Elsevier) Austria, UK, Sweden, 09 February 2021

Cardiology

Organism: Human

Tissue: Blood Vessels

Pathological State: Abdominal aortic aneurysms

536
IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer

G Jordakieva, R Bianchini, D Reichhold, J Piehslinger, A Groschopf, SA Jensen, E Mearini, G Nocentini, R Crevenna, GJ Zlabinger, SN Karagiannis, A Klaus, E Jensen-Jarolim

OncoImmunology (Taylor & Francis) Austria, Italy, UK, 08 February 2021

Oncology

Key words: IgG4, IgE, Tumor-Associated Macrophages, M2b, Allergooncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

537
Anti-inflammatory effects of Radix aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice

JH Liu, CH Hsieh, CY Liu, CW Chang, YJ Chen, TH Tsai

Journal of Ethnopharmacology (Elsevier) Taiwan, 07 February 2021

Pharmacology

Key words: 5-Fluorouracil (5-FU), Radix Aucklandiae, Intestinal Mucositis, Goblet Cell, Anti-Inflammatory

Organism: Mouse

Tissue: Small Intestine

Pathological State: Intestinal Mucositis

538
Hiltonol Cocktail Kills Lung Cancer Cells by Activating Cancer-Suppressors, PKR/OAS, and Restraining the Tumor Microenvironment

SC Chang, BX Zhang, ECY Su, WC Wu, TH Hsieh, AM Salazar, YK Lin, JL Ding

International Journal of Molecular Sciences (MDPI) Taiwan, USA, Singapore, 05 February 2021

Oncology

Key words: NSCLC (Non-Small Cell Lung Cancer), Combinatorial Treatment with Hiltonol+++ Cocktail [Hiltonol+Anti-IL6+Stattic+AG490], Tumorigenic Microenvironment, Anti- and Pro-Tumorigenic Cytokine Production, Tumor-Suppressors PKR (Protein Kinase R) And OAS (2′5′ Oligoadenylate Synthetase)

Organism: Human

Tissue: Lung

Pathological State: Cancer

539
H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice.

L Ruilian, Q Honglin, X Jun, L Jianxin, B Qingyun, C Yilin, M Haifeng

Journal of Affective Disorders (Elsevier) China, 05 February 2021

Neuroscience

Key words: Chronic Stress Stimulated Depression Model, Hippocampus, Hydrogen Sulfide, Inflammatory, Aerobic Exercise

Organism: Mouse

Tissue: Brain

540
Morphine acts on spinal dynorphin neurons to cause itch through disinhibition

E Nguyen, G Lim, H Ding, J Hachisuka, MC Ko, SE Ross

Science Translational Medicine (AAAS) USA, UK, 03 February 2021

Neuroscience

Organism: Mouse

Tissue: Skin

541
Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer

J Yang, A Eresen, J Shangguan, Q Ma, V Yaghmai, Z Zhang

OncoImmunology (Taylor & Francis) USA, 02 February 2021

Oncology

Key words: Irreversible Electroporation, Dendritic Cell Vaccine, Pancreatic Ductal Adenocarcinoma, Magnetic Resonance Imaging

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

542
Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF

K Uranowska, T Kalic, V Valtsanidis, M Kitzwögerer, H Breiteneder, C Hafner

Oncology Reports (Spandidos Publications) Austria, 02 February 2021

Oncology

Organism: Human

Cell Line: Melanoma cells

543
iTRAQ-based Quantitative Proteomic Analysis of Dural Tissues Reveals Upregulated Haptoglobin to be a Potential Biomarker of Moyamoya Disease

X Zhang, L Yin, X Jia, Y Zhang, T Liu, L Zhang

Current Proteomics (ingentaconnect) China, 01 February 2021

Proteomics

Key words: Moyamoya Disease, Dura Mater, Proteomics, iTRAQ, Haptoglobin, Strokes

544
Nerve Fibers in the Tumor Microenvironment Are Co-Localized with Lymphoid Aggregates in Pancreatic Cancer

LR Heij, X Tan, JN Kather, JM Niehues, S Sivakumar, N Heussen, G van der Kroft, SWM Olde Damink, S Lang, MR Aberle, T Luedde, NT Gaisa, J Bednarsch, DHW Liu, JPM Cleutjens, DP Modest, UP Neuman, GJ Wiltberger

Journal of Clinical Medicine (MDPI) Germany, The Netherlands, UK, Austria, 30 January 2021

Oncology

Key words: Tumor Microenvironment, Machine Learning, Nerve Fiber Density, Spatial Arrangements, Tertiary Lymphoid Structures, Pancreatic Cancer

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

545
Endothelial-Derived miR-17∼ 92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury

T Chiba, DM Cerqueira, Y Li, AJ Bodnar, E Mukherjee, K Pfister, YL Phua, K Shaikh, BT Sanders, SL Hemker, PJ Pagano, YL Wu, J Ho, S Sims-Lucas

Journal of The American Society of Nephrology (Am Soc Nephrol) USA, 29 January 2021

Nephrology

Key words: microRNA, Acute Kidney Injury, Renal Microvasculature

Pathological State: Acute Kidney Injury

546
Mer tyrosine kinase (MerTK) as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease

L Rovati, N Kaneko, F Pedica, A Monno, T Maehara, C Perugino, M Lanzillotta, S Pecetta, JH Stone, C Doglioni, AA Manfredi, S Pillai, E Della-Torre

Rheumatology (Oxford Academic) Italy, USA, Japan, 29 January 2021

Rheumatology

Key words: IgG4-Related Disease, Macrophages, MerTK, Protein S, Fibrosis

Organism: Human

Tissue: Submandibular Gland, Pancreas

Pathological State: IgG4-Related Disease

547
Effects of Nicorandil on Inflammation, Apoptosis and Atherosclerotic Plaque Progression

M Lenz, C Kaun, KA Krychtiuk, P Haider, M Brekalo, N Maier, L Goederle, CJ Binder, K Huber, C Hengstenberg, J Wojta, PJ Hohensinner, WS Speidl

Biomedicines (MDPI) Austria, 27 January 2021

Cardiology

Key words: Nicorandil, Inflammation, Apoptosis, Atherosclerosis, Plaque, Plaque Stabilization

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

548
Interleukin-24 protects against liver injury in mouse models

HH Wang, JH Huang, MH Sue, WC Ho, YH Hsu, KC Chang, MS Chang

EBioMedicine (THE LANCET) Taiwan, 25 January 2021

Hepathology

Key words: Interleukin-24, Liver Fibrosis, Thioacetamide-Induced Liver Injury, Hepatic Stellate Cells

Organism: Human

Tissue: Liver

Pathological State: Liver Fibrosis

549
Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model

CY Yeung, JSC Chiau, ML Cheng, WT Chan, SW Chang, CB Jiang, HC Lee

Gastroenterology Research and Practice (Hindawi Publishing Corporation) Taiwan, 25 January 2021

Gastroenterology

Organism: Mouse

Tissue: Small Intestine

Pathological State: Intestinal Mucositis

550
A Hepatitis B Virus-Derived Peptide Exerts an Anticancer Effect via TNF/iNOS-producing Dendritic Cells in Tumor-Bearing Mouse Model

SB Yang, MH Lee, BR Kim, YM Choi, BJ Kim

Cancers (MDPI) South Korea, 22 January 2021

Oncology

Key words: HBV-Derived Poly6 Peptide, TNF/ iNOS-Producing DCs (Tip-DCs), Type 1 Interferon (IFN-I), CD40, Cancer Immunotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

551
Androgen Plays a Carcinogenic Role in EOC via the PI3K/AKT Signaling Pathway in an AR-Dependent Manner

Y Li, S Li, Y Zhang, S Shi, S Qin, C Wang, J Du, J Ma, H Chen, H Cui

Journal of Cancer (Ivyspring International Publisher) China, 21 January 2021

Oncology

Key words: Ovarian Carcinoma, Androgen Receptor (AR), Tissue Microarray (TMA), Proliferation Promotion, PI3K/AKT Signalling Pathway

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

552
Performance and Meat Quality of Intrauterine Growth Restricted Pigs

P Matyba, T Florowski, K Dasiewicz, K Ferenc, J Olszewski, M Trela, G Galemba, M Słowiński, M Sady, D Domańska, Z Gajewski, R Zabielski

Animals (MDPI) Poland, 20 January 2021

Zoology

Key words: IUGR, Pigs, Growth Performance, Meat Quality, Sensory Evaluation

Organism: Pig

Tissue: Muscle

553
Pathological Pulmonary Vascular Remodeling is Induced by Type V Collagen in a Model of Scleroderma

RG Marangoni, BD Korman, ER Parra, APP Velosa, HV Barbeiro, V Martins, ABG dos Santos, F Soriano, WR Teodoro, PL Silva, W Tourtellotte, VL Capelozzi, J Varga, NH Yoshinari

Pathology-Research and Practice (Elsevier) Brazil, USA, 19 January 2021

Cardiology

Key words: Animal Model, Scleroderma, Collagen V, Vascular Disease, Endothelium

Organism: Rabbit

Tissue: Lung

Pathological State: Scleroderma, Vascular Disease

554
Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections

HY Park, SD Zoller, V Hegde, W Sheppard, Z Burke, G Blumstein, C Hamad, M Sprague, J Hoang, R Smith, FR Pastrana, J Czupryna, LS Miller, M López-Álvarez, M Bispo, M van Oosten, J Maarten van Dijl, KP Francis, NM Bernthal

Scientific Reports (Nature) USA, The Netherlands, 15 January 2021

Medical Imaging

Key words: Biofilms, Infectious Diseases

Pathological State: Staphylococcus aureus Infection

555
PEG-GO@ XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to …

J Zhang, L Yan, P Wei, R Zhou, C Hua, M Xiao, Y Tu, Z Gu, T Wei

European Journal of Pharmacology (Elsevier) China, USA, 14 January 2021

Oncology, Nanomedicine

Key words: Graphene Oxide, Xanthohumol, Breast Cancer Metastasis, Mitochondria, Epithelial-Mesenchymal Transition, Energy Metabolism

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

556
Macromolecular crowding as a tool to screen anti-fibrotic drugs: the Scar-in-a-Jar system revisited

NP Cavanzo, E Bigaeva, M Boersema, P Olinga, RA Bank

Frontiers in Medicine (Frontiers Media S.A.) The Netherlands, China, USA, Switzerland, 14 January 2021

Biological Methods

Key words: Macromolecular Crowding, Drug Testing, Fibrosis, Collagen, Myofibroblast

Organism: Human

Cell Line: adult primary human dermal fibroblasts

557
Mesenchymal stem cell‐glioblastoma interactions mediated via kinin receptors unveiled by cytometry

MM Pillat, Á Oliveira‐Giacomelli, M das Neves Oliveira, R Andrejew, N Turrini, J Baranova, TL Turnšek, H Ulrich

Cytometry Part A (Wiley) Brazil, 13 January 2021

Medical Image Analysis

Key words: Cytometry, Glioblastoma, Kinin Receptors, Kinin‐B1 Receptor, Kinin‐B2 Receptor, Mesenchymal Stem Cells

Organism: Human

Cell Line: Glioblastoma (U87) cells, Mesenchymal stem cell

558
Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition

YY Wang, B Zhao, MM Wu, XL Zheng, L Lin, DM Yin

Nature Communications (Nature) China, 12 January 2021

Neuroscience

Key words: Molecular Neuroscience, Schizophrenia

Organism: Mouse

Tissue: Brain

559
Stem Cell-Derived Respiratory Epithelial Cell Cultures as Human Disease Models

JC Orr, RE Hynds

American Journal of Respiratory Cell and Molecular Biology (Wiley) UK, 11 January 2021

Stem Cell Research

Key words: Respiratory Epithelium, Epithelial Cells, Cell Culture, Cloning, Stem Cells

560
Overexpression of GLUT3 promotes metastasis of triple‐negative breast cancer by modulating the inflammatory tumor microenvironment

TH Tsai, CC Yang, TC Kou, CE Yang, JZ Dai, CL Chen, CW Lin

Journal of Cellular Physiology (Wiley) Taiwan, 09 January 2021

Oncology

Key words: Glycolysis, Inflammation, Triple‐Negative Breast Cancer, Tumor Microenvironment, Tumor‐Associated Macrophage

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

561
Development and Validation of Sorafenib-eluting Microspheres to Enhance Therapeutic Efficacy of Transcatheter Arterial Chemoembolization in a Rat Model of of Hepatocellular Carcinoma

W Park, S Cho, J Ji, RJ Lewandowski, AC Larson, DH Kim

Radiology: Imaging Cancer (Royal Society of Chemistry) USA, 08 January 2021

Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

562
Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade

C Bangert, K Rindler, T Krausgruber, N Alkon, FM Thaler, H Kurz, T Ayub, D Demitras, N Fortelny, V Vorstandlechner, WM Bauer, T Quint, M Mildner, C Jonak, A Elbe-Bürger, J Griss, C Bock, PM Brunner

Science Immunology (Science) Austria, 08 January 2021

Immunology, Dermatology

Organism: Human

Tissue: Skin

Pathological State: Dermatitis

563
Differential expression of microRNA miR-150-5p in IgA nephropathy as a potential mediator and marker of disease progression.

IZA Pawluczyk, A Didangelos, SJ Barbour, L Er, JU Becker, R Martin, S Taylor, JS Bhachu, EG Lyons, R Jenkins, D Fraser, K Molyneux, J Perales-Paton, J Saez-Rodriguez, J Barratt

Kidney International (Elsevier) UK, Canada, Germany, Spain, 06 January 2021

Nephrology

Key words: IgA Nephropathy, microRNA

Organism: Human

Tissue: Kidney

Pathological State: IgA nephropathy

564
Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1

Z Liu, L Sun, Y Cai, S Shen, T Zhang, N Wang, G Wu, W Ma, ST Li, C Suo, Y Hao, WD Jia, GL Semenza, P Gao, H Zhang

Cancer Research (AACR) China, USA, 05 January 2021

Oncology

565
Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation

Tolani F Olonisakin, Tomeka Suber, Shekina Gonzalez-Ferrer, Zeyu Xiong, Hernán F Peñaloza, Rick van der Geest, Yuting Xiong, David O Osei-Hwedieh, Jesús Tejero, Matthew R Rosengart, Wendy M Mars, Daria Van Tyne, Andreas Perlegas, Samuel Brashears, Daniel B Kim-Shapiro, Mark T Gladwin, Michael A Bachman, Eldad A Hod, Claudette St Croix, Yulia Y Tyurina, Valerian E Kagan, Rama K Mallampalli, Anuradha Ray, Prabir Ray, Janet S Lee

The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, 04 January 2021

Immunology

Organism: Mouse

Tissue: Liver

566
IN VITRO CHARACTERIZATION OF HYDROXYAPATITE-BASED BIOMATERIALS, USING MESENCHYMAL STEM CELL CULTURES FROM HUMAN BONE …

LE Sima, RM Varut, O Gingu, G Sima, C Teisanu, J Neamtu

Journal of Science and Arts (Josa.ro) Romania, 30 December 2020

Biological Materials

Key words: Hydroxyapatite, Calcium Fructoborate, Mesenchymal Stem Cell, Human Bone Marrow

Organism: Human

Cell Line: Mesenchymal stem cells

567
Persistent inhibition of Candida albicans biofilm and hyphae growth on titanium by graphene nanocoating

SV Agarwalla, K Ellepola, N Silikas, AHC Neto, C Jayampath, SV Rosa

Dental Materials (Elsevier) Singapore, USA, UK, 25 December 2020

Biological Materials

Key words: Implant, Surface Free Energy, Contact Angle, Topography, Microbial Attachment, Antiadhesive Coating, Peri-Implantitis

Cell Line: C. albicans

568
Obesity is associated with shorter telomere length in prostate stromal cells in men with aggressive prostate cancer

CE Joshu, CM Heaphy, JR Barber, J Lu, R Zarinshenas, C Davis, M Han, TL Lotan, KS Sfanos, AM De Marzo, AK Meeker, EA Platz

Cancer Prevention Research (AACR) USA, 22 December 2020

Oncology

569
PD‐L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer

TJ Miller, CC Anyaegbu, TF Lee‐Pullen, LJ Spalding, CF Platell, MJ McCoy

Cancer Science (Wiley) Australia, 20 December 2020

Oncology

Key words: CD8, Colon Cancer, Dendritic Cells, PD‐L1, T Cells

570
Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma

T Tashiro, K Imamura, Y Tomita, D Tamanoi, A Takaki, K Sugahara, R Sato, K Saruwatari, S Sakata, M Inaba, S Ushijima, N Hirata, T Sakagami

International Journal of Molecular Sciences (MDPI) Japan, USA, 19 December 2020

Oncology

Key words: Anaplastic Lymphoma Kinase (ALK), B Cell, Heterogeneity, Immune Checkpoint, Large Cell Neuroendocrine Carcinoma (LCNEC), Neuroendocrine Tumors (NET), Regulatory T-Cells (Tregs), Programmed Death-Ligand 1 (PD-L1), Tumor-Infiltrating Lymphocyte (TIL), Tumor-Immune Microenvironments (TIME)

Organism: Human

Tissue: Lung

Pathological State: Cancer

571
Parp1-Dependent DNA Double-Strand Break Repair in Irradiated Late Pachytene Spermatocytes

E A Ahmed, A M Alzahrani, H Scherthan

DNA and Cell Biology (Mary Ann Liebert Inc.) Saudi Arabia, Egypt, Germany, 18 December 2020

Reproductive Medicine

Key words: Alternative NHEJ, DNA Repair, First Meiotic Prophase, γ-H2AX, Homologous Recombination, Parp1, Spermatogenesis

Organism: Human

Cell Line: Spermatocytes

572
Differential mast cell phenotypes in benign versus cancer tissues and prostate cancer oncologic outcomes

H Hempel Sullivan, JP Maynard, CM Heaphy, J Lu, AM De Marzo, TL Lotan, CE Joshu, KS Sfanos

The Journal of Pathology (Wiley) USA, 18 December 2020

Oncology

Key words: Prostate Cancer, Mast Cells, Metastases, CXCR4, TFE3, KIT, Microenvironment

Organism: Human

Tissue: Prostate

Pathological State: Cancer

573
ZFHX3 Knockdown Dysregulates Mitochondrial Adaptations to Tachypacing in Atrial Myocytes through Enhanced Oxidative Stress and Calcium Overload

B Lkhagva, YK Lin, YC Chen, WL Cheng, S Higa, YH

Acta Physiologica (Wiley) Taiwan, Japan, 17 December 2020

Physiology

Key words: Atrial Fibrillation, Calcium, Mitochondria, Tachypacing, ZFHX3

Organism: Human

Cell Line: HL‐1 cells

574
CD4+ CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum

H Allard-Chamard, F Alsufyani, N Kaneko, K Xing, C Perugino, VS Mahajan, JL Wheat, GS Deepe Jr, J Loyd and S Pillai

The Journal of Immunology (American Association of Immunologists) Canada, Saudi Arabia, Japan, USA, 16 December 2020

Immunology

Organism: Human

Tissue: Mediastinum

Pathological State: Mediastinitis

575
Tribbles Pseudokinase 3 Contributes to Cancer Stemness of Endometrial Cancer Cells by Regulating β-Catenin Expression

WL Wang, GC Hong, PJ Chien, YH Huang, HT Lee, PH Wang, YC Lee, WW Chang

Cancers (MDPI) Taiwan, 15 December 2020

Oncology

Key words: Tribbles Pseudokinase 3, Endometrial Cancer, Cancer Stem Cells, β-Catenin, Epithelial–Mesenchymal Transition

Organism: Human

Cell Line: Endometrial Cancer Cell Lines (AN3CA and HEC1A)

576
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

TJ Hark, NR Rao, C Castillon, T Basta, S Smukowski, H Bao, A Upadhyay, E Bomba-Warczak, T Nomura, ET O'Toole, GP Morgan, L Ali, T Saito, C Guillermier, TC Saido, ML Steinhauser, MHB Stowell, ER Chapman, A Contractor, JN Savas

Cell Systems (Cell Press) USA, Japan, 15 December 2020

Neuroscience

Key words: Alzheimer's Diseasea, Myloid Beta, Synaptic Dysfunction, Presynapse, Synaptic Vesicles, Proteostasis, Mass Spectrometry, Proteomics, APP Knockin Mice

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

577
Multicohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors

K Ando, A Ozonoff, SY Lee, M Viosine, JT Parker, R Nakanishi, S Nishimura, J Yang, Z Grace, B Tran, TJ Diefenbach, Y Maehara, H Yasui, T Irino, R Salgia, M Terashima, P Gibbs, RK Ramanathan, E Oki, M Mori, M Kulke, K Hartshorn, A Bharti

Clinical Colorectal Cancer (Elsevier) USA, Japan, Australia, 10 December 2020

Oncology

Organism: Human

Tissue: Stomach

Pathological State: Cancer

578
Spatiotemporal Up-Regulation of Mu Opioid Receptor 1 in Striatum of Mouse Model of Huntington's Disease Differentially Affecting Caudal and Striosomal Regions

R Morigaki, JH Lee, T Yoshida, C Wüthrich, D Hu, JR Crittenden, A Friedman, Y Kubota, AM Graybiel

Frontiers in Neuroanatomy (Frontiers Media S.A.) USA, Japan, 10 December 2020

Neuroscience

Key words: Mu Opioid Receptors, Huntington’s Disease, Neostriatum, Movement Disorders, Mood Disorders, Animal Models of Human Disorders, Striosome

Organism: Mouse

Tissue: Brain

Pathological State: Huntington's Disease

579
Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro

L Elena Sima, A Bonciu, M Baciu, I Anghel, LN Dumitrescu, L Rusen, V Dinca

Nanomaterials (MDPI) Romania, 09 December 2020

Nanomedicine

Key words: Zirconia, Mesenchymal Stem Cells, Micro-Nano Topography, Osteogenic Differentiation, Bone-Anchored Hearing Aid (BAHA)

Organism: Human

Cell Line: hMSCs

580
The effect of dietary supplementation with high-or low-dose omega-3 fatty acid on inflammatory pathology after traumatic brain injury in rats

EK Black, JK Phillips, J Seminetta, J Bailes, JM Lee, JD Finan

Translational Neuroscience (degruyter) USA, 09 December 2020

Neuroscience

Key words: Dietary Supplementation, Docosahexanoic Acid, Eicosapentaenoic Acid, Neuroinflammation, Neuroprotection, Omega-3 Fatty Acid, Traumatic Brain Injury

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

581
Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis

W Kang, Q Wang, Y Dai, H Wang, M Wang, J Wang, D Zhang, P Sun, T Qi, X Jin, Z Cui

Cell Death & Disease (Nature) China, 07 December 2020

Oncology

Key words: Bladder Cancer, Long Non-Coding RNAs, Oncogenesis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

582
Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients

H Wang, C Feng, M Lu, B Zhang, Y Xu, Q Zeng, J Xi, J Zhou, X Ying, J Zhang, W Yue, X Pei

Translational Oncology (Elsevier) China, 06 December 2020

Oncology

Key words: Liver Cancer, Single-Cell Transcriptome, Cancer-Distinct Fibroblast, SPARCL1

Organism: Human

Tissue: Liver

Pathological State: Cancer

583
Lactic acidosis interferes with toxicity of perifosine to colorectal cancer spheroids: multimodal imaging analysis

B Pavlatovská, M Machálková, P Brisudová, A Pruška, K Štěpka, J Michálek, T Nečasová, P Beneš, J Šmarda, J Preisler, M Kozubek, J Navrátilová

Frontiers in Oncology (Frontiers Media S.A.) Czech Republic, Switzerland, China, 04 December 2020

Oncology

Key words: Perifosine, Akt Kinase, Tumor Environment, Lactic Acidosis, Alkalization, Signal Co-Registration, Mass Spectrometry Imaging, Colorectal Cancer

Organism: Human

Cell Line: HT-29 and HCT-116 cells

584
AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

G Caluori, E Odehnalova, T Jadczyk, M Pesl, I Pavlova, L Valikova, S Holzinger, V Novotna, V Rotrekl, A Hampl, M Crha, D Cervinka, Z Starek

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) Czech Republic, France, Poland, Germany, 03 December 2020

Cardiology

Key words: Pulsed Field Ablation, Irreversible Electroporation (IRE), Radiofrequency Ablation, Atrial Fibrillation, Ventricular Arrhythmia (VA), Preclinical Cardiology

Organism: Pig

Tissue: Heart

585
Shear stress-exposed pulmonary artery endothelial cells fail to upregulate HSP70 in chronic thromboembolic pulmonary hypertension

W Salibe-Filho, TLS Araujo, EG Melo, LBCT Coimbra, MS Lapa, MMP Acencio, O Freitas-Filho, VL Capelozzi, LR Teixeira, CJCS Fernandes, F Biscegli Jatene, FRM Laurindo, M Terra-Filho

PLoS One (PLOS) Brazil, 03 December 2020

Cardiology

Key words: Shear Stresses, Endothelial Cells, Heat Shock Response, Pulmonary Arteries, Peas, Flow Cytometry, Nitric Oxide, Pulmonary Hypertension

Organism: Human

Pathological State: Pulmonary hypertension

Cell Line: HPAECs

586
Infiltration of metastatic lymph nodes with PD-1+ T cells is associated with improved disease-free and overall survival in resected N+ NSCLC

S Wang, Y Song, MA Morse, P Sun, G Qiao, X Wang, X Zhou, A Hobeika, J Ren, HK Lyerly

American Journal of Cancer Research (e-Century Publishing Corporation) China, USA, 01 December 2020

Oncology

Key words: NSCLC, Metastatic Lymph Node, T Cell Subsets, PD-1, TIM-3

Organism: Human

Tissue: Lung

Pathological State: Cancer

587
The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients

G Spanier, I Ugele, F Nieberle, L Symeou, S Schmidhofer, A Brand, J Meier, S Spoerl, R Krupar, P Rümmele, P Siska, K Renner, K Peter, M Gerken, P Beckhove, TE Reichert, M Kreutz, K Singer

Cancer Letters (Elsevier) Germany, 01 December 2020

Oncology

Key words: OSCC, Diabetes Mellitus, TIL, Metabolism, Prognosis

Organism: Human

Pathological State: Cancer

588
p21‐activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1

H Huang, Q Xue, X Du, J Cui, J Wang, D Cheng, J Li, Y Zheng, G Huang, K Zhang, K Liu, J Lu, J Zhao, X Chen, Z Dong, X Li

Molecular Carcinogenesis (Wiley) China, 01 December 2020

Oncology

Key words: Cell Proliferation, Esophageal Squamous Cell Carcinoma, LASP1, Metastasis, PAK4

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

589
Cross-Reactive Effects of Vaccines: Heterologous Immunity between Tetanus and Chlamydia

M Stojanovic, I Lukic, E Marinkovic, A Kovacevic, R Miljkovic, J Tobias, I Schabussova, M Zlatovic, T Barisani-Asenbauer, U Wiedermann, A Inic-Kanada

Vaccines (MDPI) Serbia, Austria, 01 December 2020

Immunology

Key words: Vaccination, Heterologous Immunity, Antibodies, Tetanus, Chlamydia, Cross-Reactivity

Organism: Human

Cell Line: Human conjunctival epithelial cell line

590
Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats

W Wang, X Liu, Z Yang, H Shen, L Liu, Y Yu, T Zhang

Frontiers in Neuroscience (Frontiers Media S.A.) China, 30 November 2020

Neuroscience

Key words: Levodopa, Hippocampus, Global Cerebral Ischemia Reperfusion Injury, Structural Synaptic Plasticity, Cognitive Function

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

591
Characterization of epithelial cells, connective tissue cells and immune cells in human upper airway mucosa by immunofluorescence multichannel image cytometry: a pilot study

AI Giotakis, J Dudas, R Glueckert, D Dejaco, J Ingruber, F Fleischer, V innerhofer, L Pinggera, L Bektic-Tadic, SAM Gabriel, H Riechelmann

Histochemistry and Cell Biology (Springer) Austria, 29 November 2020

Medical Image Analysis

Key words: Image Cytometry, Fluorescent Antibody Technique, Immunohistochemistry, Nasal Mucosa, Sinusitis

Organism: Human

Tissue: Mucosa

Pathological State: Chronic Rhinosinusitis

592
MicroRNA-146a suppresses tumor malignancy via targeting vimentin in esophageal squamous cell carcinoma cells with lower fibronectin membrane assembly

HY Chang, CH Lee, YS Li, JT Huang, SH Lan, YF Wang, WW Lai, YC Wang, YJ Lin, HS Liu, HC Cheng

Journal of Biomedical Science (BMC) Taiwan, 28 November 2020

Oncology

Key words: ESCC, MiR-146a, Vimentin, Cell Migration, Invasion

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

593
Lactobacillus Attenuate the Progression of Pancreatic Cancer Promoted by Porphyromonas Gingivalis in K-rasG12D Transgenic Mice

SM Chen, LJ Hsu, HL Lee, CP Lin, SW Huang, CJL Lai, CW Lin, WT Chen, YJ Chen, YC Lin, CC Yang, MS Jan

Cancers (MDPI) Taiwan, 26 November 2020

Oncology

Key words: Caerulein, Lactobacillus, Pancreatic Ductal Adenocarcinoma, Porphyromonas Gingivalis, Transforming Growth Factor-β

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

594
Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages

YY Wang, HD Chen, S Lo, YK Chen, YC Huang, S CS Hu, YC Hsieh, AC Hung, MF Hou, SS F Yuan

Cancers (MDPI) Taiwan, UK, 26 November 2020

Oncology

Key words: Visfatin, Breast Cancer, Tumor-Associated Macrophages, CXCL1

Organism: Human

Tissue: Breast

Pathological State: Cancer

595
Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice

K Han, X Jin, X Guo, G Cao, S Tian, Y Song, Y Zuo, P Yu, G Gao, YZ Chang

Free Radical Biology and Medicine (Elsevier) China, 26 November 2020

Neuroscience

Key words: Nrf2, Motor Dysfunction, Brain Iron Metabolism, Oxidative Stress, FPN1

Organism: Mouse

Tissue: Brain

596
Neuropathology changed by 3-and 6-months low-level PM 2.5 inhalation exposure in spontaneously hypertensive rats

HC Chuang, HC Chen, PJ Chai, HT Liao, CF Wu, CL Chen, MK Jhan, HI Hsieh, KY Wu, TF Chen, TJ Cheng

Particle and Fibre Toxicology (Springer) Taiwan, 26 November 2020

Neuroscience

Key words: Air Pollution, Autophagy, Central Nervous System Toxicity, Particulate Matter, Tau

Organism: Rat

Tissue: Brain

597
Electric Pulse Responsive Magnetic Nanoclusters Loaded with Indoleamine 2, 3-Dioxygenase Inhibitor for Synergistic Immuno-Ablation Cancer Therapy

B Yu, W Zhang, K Kwak, H Choi, DH Kim

ACS Applied Materials & Interfaces (ACS Publications) USA, 25 November 2020

Oncology

Key words: Local Ablation, Irreversible Electroporation, Indoleamine 2, 3-Dioxygenase Inhibitor, Magnetic Nanoparticles, Immunotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

598
Development of Rift valley fever encephalitis in rats is mediated by early infection of olfactory epithelium and neuroinvasion across the cribriform plate

DA Boyles, MM Schwarz, JR Albe, CM Mcmillen, KJ O'Malley, DS Reed, AL Hartman

Journal of General Virology (Microbiology Society) USA, 24 November 2020

Virology

Key words: Aerosol, Cribriform Plate, Encephalitis, Olfactory Bulb, Pathogenesis, Rift Valley Fever Virus

Organism: Rat

Tissue: Mucosa

Pathological State: Encephalitis

599
Time-resolved analysis of Staphylococcus aureus invading the endothelial barrier

EJM Raineri, H Yedavally, A Salvati, JM van Dijl

Virulence (Taylor & Francis) The Netherlands, 22 November 2020

Microbiology

Key words: Staphylococcus Aureus, MRSA, Endothelium, Invasion, Intracellular

Organism: Human

Cell Line: HUVECs

600
Type II natural killer T cells contribute to protection against systemic methicillin-resistant Staphylococcus aureus infection

S Genardi, L Visvabharathy, L Cao, E Morgun, Y Cui, C Qi, YH Chen, L Gapin, E Berdyshev, CR Wang

Frontiers in Immunology (Frontiers Media S.A.) USA, 18 November 2020

Immunology

Key words: Staphylococcus Aureus, Natural Killer T Cells, CD1, Lipid Antigens, Cytokine, Knockout Mice

Organism: Mouse

Tissue: Kidney

Pathological State: Staphylococcus aureus Infection

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