P2X7 receptor


P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma
Frontiers in Oncology

Arnaud-Sampaio et al. addressed the persistent problem of drug resistance in cancer and elucidated the role of the P2X7 receptor in chemoresistance, using TissueFAXS platform for image acquisition and StrataQuest software for in-depth cytometric quantifications. The paper was published in Frontiers in Oncology.

Cytotoxic CD8+ T cells may be drivers


Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome
scientific reports

In this study, published in scientific reports Nature, Kaneko et al. investigated the role of CD4+ and CD8+ T cell subsets in salivary glands of patients with Sjögren’s syndrome. In order to perform an in-depth quantitative analysis, the power of TissueFAXS platform, and both TissueQuest and StrataQuest software were utilized.

Adverse Effects of Single


A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells

This study from Liang et al. (University of Gothenburg) assessed phenotypic and functional characteristics of tumor infiltrating lymphocytes within colorectal liver metastases (CRLM). For the in-situ tissue cytometry analysis, with the main focus on CD103+CD8+ TRM cells, the power of TissueFAXS CHROMA and StrataQuest was utilized.

Adverse Effects of Single


The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes


Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution


Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging


Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

The role of S100A9


The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells
Cancer Immunology, Immunotherapy

Kung et al. recently published a study, in the journal Cancer, evaluating the prognostic role of S100A9 (acting as chemoattractant for circulatory monocytes) in pancreatic ductal adenocarcinoma as well as its influence on PD-L1 expression. TissueFAXS PLUS and StrataQuest were used to assess co-expression of PD-L1 and S100A9 in human PDAC tissues.

SynNotch-CAR T


SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Differential localization


Differential localization and limited cytotoxic potential of duodenal CD8+ T cells
The Journal of Clinical Investigation

In a recent study published in The Journal of Clinical Investigation, Mvaya et al. were able to demonstrate the limited potential of duodenal CD8+ T cells in tissue samples from people living with HIV. High content immunophenotyping within duodenal tissue sections was performed using TissueFAXS i PLUS and the single cell analysis software TissueQuest.



Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients
Signal Transduction and Targeted Therapy

Zhang et al, published a study in the journal Signal Transduction Targeted Therapy, with the main focus on the investigation of the effect of Azvudine, in SARS-CoV-2 infected rhesus macaques as well as in COVID-19 patients. The group used TissueFAXS Q as well as TissueQuest to quantify the viral load, immune-status and TUNEL staining within thymus tissues.

Functional Impairment


Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia

In a recent study published in the journal Immunity, Collins et al (Ragon Institute of MGH, MIT and Harvard) were able to show key immunologic and virologic parameters of durable HIV control. For high resolution visualization of the virus, lymph node tissues were marked with HIV specific RNAScope probes and acquired using TissueFAXS Q.

AC-265347 Inhibits


AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia
International Journal of Molecular Sciences

This recently published study was conducted within the CaSR Biomedicine Training network. Gonçalves-Alves et al. were able to demonstrate the inhibitory effect of the drug AC-265347 on neuroblastoma tumor growth. Expression of various markers (Ki67, CaSR, CD44, TrkA, NF68) was assessed by using TissueFAXS PLUS and StrataQuest.

Filter publications

Customer Publications (A total of 2213 papers published)

Cell Proliferation Volume 38, Issue 4, pages 177–203, August 2005

Cell Proliferation (Wiley) Poland, 11 August 2005


Welcome to the 15th Annual Meeting of the German Society for Cytometry, DGfZ

Cell Proliferation (Wiley) Germany, 11 August 2005


Pimecrolimus leads to an apoptosis-induced depletion of T cells but not Langerhans cells in patients with atopic dermatitis

Wolfram Hoetzenecker, Rupert Ecker, Tamara Kopp, Anton Stuetz, Georg Stingl, Adelheid Elbe-Bürger

Journal of Allergy and Clinical Immunology (Elsevier) Austria, 06 April 2005

Allergy Research

Key words: Atopic dermatitis, Langerhans cells, T cells, apoptosis, corticosteroids, pimecrolimus

Cytomics goes 3D: toward tissomics

Ecker RC, Tarnok A

Cytometry Part A (Wiley) Austria, 24 March 2005


Regenerative and predictive medicine of cardiovascular disease: The 9th Leipziger workshop and the 2nd international workshop on slide based cytometry

Dominik Lenz, Markus J Barten, Sabine Hiller, Attila Tárnok, Ulrich Sack

Cytometry Part A (Wiley) Germany, 24 February 2005


Key words: Predictive medicine, regenerative medicine, stem cells, cytomics, laser scanning cytometry

Autocrine IL-10 partially prevents differentiation of neonatal dendritic epidermal leukocytes into Langerhans cells

Souyet Chang-Rodriguez, Rupert Ecker, Georg Stingl, Adelheid Elbe-Bürger

Journal of Leukocyte Biology (JLB) Austria, 14 June 2004


Key words: Antigen presentation/processing cytokines, cytokine receptors, dendritic cells skin

Microscopy-based multicolor tissue cytometry at the single-cell level

Rupert C Ecker, Georg E Steiner

Cytometry Part A (Wiley) Austria, 17 May 2004


Key words: Cytomics, tissue cytometry, multicolor staining, quantitative histology, pattern recognition

Application of spectral imaging microscopy in cytomics and fluorescence resonance energy transfer (FRET) analysis.

Ecker RC, de Martin R, Steiner GE, Schmid JA

Journal of the International Society for Advancement of Cytometry (Wiley) Austria, 17 May 2004


Decreased hippocampal mineralocorticoid:glucocorticoid receptor ratio is associated with low birth weight in female cynomolgus macaque neonates

Shirlene X Ong, Keefe Chng, Michael J Meaney, Jan P Buschdorf

Journal of Molecular Endocrinology (Society for Endocrinology) Austria, 16 April 2004

Reproductive Medicine

Key words: Glucocorticoid receptor cynomolgus macaque low birth weight MR:GR ratio

Inhibition of restenosis by tissue factor pathway inhibitor: in vivo and in vitro evidence for suppressed monocyte chemoattraction and reduced gelatinolytic activity

Christoph W Kopp, Thomas Hölzenbein, Sabine Steiner, Rodrig Marculescu, Helga Bergmeister, Daniela Seidinger, Isabella Mosberger, Christoph Kaun, Manfred Cejna, Reinhard Horvat, Johann Wojta, Gerald Maurer, Bernd R Binder, Johannes M Breuss, Rupert C Ecker, Rainer de Martin, and Erich Minar

Blood (American Society of Hematology) Austria, 01 March 2004


Key words: VSMC proliferation and migration, vascular restenosis

Using web-based animations to teach histology

Marc AS Brisbourne, Susan S-L Chin, Erica Melnyk, David A Begg

The Anatomical Record (Wiley) Austria, 28 February 2002


Key words: Animation, computer-assisted learning, CAL, histology, Internet, education, medical, mental modeling, microscopy

Automated data acquisition by confocal laser scanning microscopy and image analysis of triple stained immunofluorescent leukocytes in tissue

Georg Erich Steiner, Rupert Christian Ecker, Gero Kramer, Felix Stockenhuber, Michael Johann Marberger

Journal of Immunological Methods (Elsevier) Austria, 17 March 2000

Medical Image Analysis

Detection of Epstein-Barr Virus in Hodgkin-Reed-Sternberg Cells: No Evidence for the Persistence of Integrated Viral Fragments in Latent Membrane Protein-1 (LMP-1)-Negative Classical Hodgkin's Disease

Andrea Staratschek-Jox, Sascha Kotkowski, Gazanfer Belge, Thomas Rüdiger, Jörn Bullerdiek, Volker Diehl, Jürgen Wolf

The American Journal of Pathology (Elsevier) Germany, 10 January 2000


Key words: Hodgkin's disease, EBV genome, in situ hybridization


TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies).
You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.