Checkpoint Molecules Predict Response to Immunotherapy in Cancer


Checkpoint Molecules Predict Response to Immunotherapy in Cancer

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Community-developed Checklists Enhance Reproducibility of Microscopy Images


Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma


AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Characterization of the Spatial Immune Context of Lung Cancer


Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma


COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis


Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Tumor Microenvironment Characterization of Rectal Cancer


Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Adverse Effects of Single


The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes


Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution


Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging


Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T


SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer


CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 2600 papers published)

Intratumoral heterogeneity in anaplastic large cell lymphoma of non-common subtype

Dmitriy Abramov, Ilske Oschlies, Dmitriy Konovalov, Christine Damm-Welk, Wilhelm Wössmann, Wolfram Klapper

Journal of Hematopathology (Springer) Germany, Russia, 14 January 2012


Key words: Anaplastic large cell lymphoma, ALK, Digital image analysis

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

Tubular epithelial syndecan-1 maintains renal function in murine ischemia/reperfusion and human transplantation

Celie JW, Katta KK, Adepu S, Melenhorst WB, Reijmers RM, Slot EM, Beelen RH, Spaargaren M, Ploeg RJ, Navis G, van der Heide JJ, van Dijk MC, van Goor H, van den Born J

Kidney international (Elsevier) The Netherlands, 11 January 2012


Key words: kidney transplantation, proliferation, renal epithelial cell, renal ischemia-reperfusion, transplant outcomes

Organism: Mouse

Tissue: Kidney

Pathological State: Organ Transplantation

A role for Epstein–Barr viral BALF1 in facilitating tumor formation and metastasis potential

Wen-Li Hsua, Pei-Jung Chungb, Ming-Hsien Tsaia, Cicero Lee-Tian Changc, Chih-Lung Liang

Virus research (Elsevier) Taiwan, 02 January 2012

Oncology, Virology

Key words: EBV, BALF1, Transformation, Tumor, Metastasis

Organism: Mouse

Pathological State: Epstein–Barr virus Infection, Cancer

Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosis

X Yin, ME Pavone, Z Lu, JJ Wei, JJ Kim

Journal of Clinical Endocrinology and Metabolism (Oxford University Press) USA, 01 January 2012

Reproductive Medicine

Organism: Human

Tissue: Endometrium, Ovaries

Pathological State: Endometriosis

Robotic Microscopy and information technology to increase accuracy, sensitivity and availability of blood cell analyses

V Medovyi, A Pyatnitskiy

Current Microscopy Contributions to Advances in Science and Technology (FORMATEX) Russia, 01 January 2012


Key words: robotic microscopy, blood smear analysis, virtual slide, laboratory telemedicine, image cytometry, virtual microscopy, image analysis, pattern recognition, artificial intelligence

Magnetization transfer MRI in pancreatic cancer xenograft models

Weiguo Li, Zhuoli Zhang, Jodi Nicolai, Guang-Yu Yang, Reed A Omary, Andrew C Larson

Magnetic Resonance in Medicine (Wiley) USA, 28 December 2011


Key words: Magnetization transfer, fibrosis, pancreatic cancer, mouse xenograft model

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

MicroRNA-1 and microRNA-206 improve differentiation potential of human satellite cells: a novel approach for tissue engineering of skeletal muscle

M Koning, PMN Werker, DWJ van der Schaft, RA Bank, MC Harmsen

Tissue Engineering Part A (Mary Ann Liebert Inc.) The Netherlands, 20 December 2011

Regenerative Medicine

Organism: Human

Tissue: Muscle

Macrophages in human colorectal cancer are pro-inflammatory and prime T cells towards an anti-tumour type-1 inflammatory response

Siew-Min Ong, Yann-Chong Tan, Ottavio Beretta, Dongsheng Jiang, Wei-Hseun Yeap, June J Y Tai, Wing-Cheong Wong, Henry Yang, Herbert Schwarz, Kiat-Hon Lim, Poh-Koon Koh, Khoon-Lin Ling, Siew-Cheng Wong

European Journal of Immunology (Wiley) Singapore, 12 December 2011


Key words: Chemokines, cytokines, spheroid model, T-cell co-stimulation, tumour-associated macrophages (TAMs)

Organism: Human

Tissue: Colon

Pathological State: Cancer

Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease

KE Glajch, SM Fleming, DJ Surmeier, P Osten

Behavioural Brain Research (Elsevier) USA, 09 December 2011


Key words: Parkinson's disease, 6-OHDA, Mouse, Behavioral test, Sensorimotor impairment, Medial forebrain bundle

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's disease

Digital Transplantation Pathology: Combining Whole Slide Imaging, Multiplex Staining and Automated Image Analysis

K Isse, A Lesniak, K Grama, B Roysam, M I Minervini A J Demetris

American Journal of Transplantation (Wiley) USA, 04 November 2011

Transplantation Medicine

Key words: Allograft pathology, C4d, digital image, fibrosis, quantitative analysis, quantum dots, three-dimensional imaging

Gas challenge–blood oxygen level-dependent (GC-BOLD) MRI in the rat Novikoff hepatoma model

Yang Guo, Ning Jin, Rachel Klein, Jodi Nicolai, Guang-Yu Yang, Reed A Omary, Andrew C Larson

Magnetic Resonance Imaging (Elsevier) USA, 04 November 2011


Key words: Gas challenge–blood oxygen level dependent (GC-BOLD), MRI, Rat Novikoff hepatoma, Tumor angiogenesis, Tumor microvessel density

Organism: Rat

Tissue: Liver

Pathological State: Cancer

Evaluation of Functional and Structural Alterations in Muscle Tissue after Short-Term Cold Storage in a New Tissue Preservation Solution

Wille T, Gonder S, Thiermann H,Seeger T,Rauen U, Worek F

Cells Tissues Organs (Karger) Germany, 01 November 2011

Regenerative Medicine

Key words: Muscle tissue, preservation solution

Organism: Mouse

Tissue: Muscle

Epithelial Area Detection in Cytokeratin Microscopic Images Using MSER Segmentation in an Anisotropic Pyramid

Cristian Smochina, Radu Rogojanu, Vasile Manta, Walter Kropatsch

Pattern Recognition in Bioinformatics (Springer) Romania, Austria, 01 November 2011

Medical Image Analysis

Key words: Crypt segmentation, Anisotropic diffusion pyramid, MSER, Biomedical imaging, Pathology, Microscopy, Fluorescence microscopy, Image analysis

Organism: Human

Tissue: Colon

Pathological State: Cancer

Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands

Kwi Young Kang, Hyun-Ok Kim, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Dong-Il Sun, Joo Yeon Jhun, Hye Jwa Oh, Sung-Hwan Park, Ho-Youn Kim

Arthritis Research and Therapy (Springer) South Korea, 26 October 2011


Key words: Serum il-21, anti-ro ssa antibody, synovial membrane cell, labial salivary gland, il-21r expression, il-21 gene, anti-ro la antibody, salivary gland biopsy, tfh cell, ectopic germinal center, encephalitis, th17 cell, nkt cell, il-21 concentration, ductal cell

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's syndrome

Regulation of Oocyte and Cumulus Cell Interactions by Intermedin/Adrenomedullin 2

Chia Lin Chang, Hsin-Shih Wang, Yung-Kuei Soong, Shang Yu Huang, Shun Yuan Pa, Sheau Yu Teddy Hsu

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) Taiwan, USA, 18 October 2011

Reproductive Medicine

Key words: Apoptosis, Bioinformatics, Cell Compartmentation, Cyclic AMP (cAMP), G Protein-coupled Receptors (GPCR), Ovary Peptide Hormones Adrenomedullin CGRP

Organism: Mouse

Tissue: Ovaries

Sampling step importance in hierarchical semantic segmentation of microscopic images

Smochina C, Manta V, Kropatsch W

System Theory, Control, and Computing (IEEEXplore) Romania, Austria, 16 October 2011


Key words: Semantic segmentation of microscopic images

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

Tanaya Shree, Oakley C Olson, Benelita T Elie, Jemila C Kester, Alfred L Garfall, Kenishana Simpson, Katherine M Bell-McGuinn, Emily C Zabor, Edi Brogi, Johanna A Joyce

Genes and Development (CSH Press) USA, 12 October 2011


Key words: Cancer metastasis, chemotherapy, tumor microenvironment, proteolysis paclitaxel

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

Activation-Induced Cytidine Deaminase (AID)-Associated Multigene Signature to Assess Impact of AID in Etiology of Diseases with Inflammatory Component

Diana Mechtcheriakova, Yury Sobanov, Gabriele Holtappels, Erika Bajna, Martin Svoboda, Markus Jaritz, Claus Bachert, Erika Jensen-Jarolim

PLoS One (PLOS) Austria, Belgium, 03 October 2011


Key words: Immunity, inflamation

Organism: Human

Tissue: Mucosa

Pathological State: Rhinosinusitis, Nasal polyps

Evaluating the role of connexin43 in congenital heart disease: Screening for mutations in patients with outflow tract anomalies and the analysis of knock-in mouse …

GY Huang, LJ Xie, KL Linask, C Zhang, XQ Zhao, YI Yang, GM Zhou, YJ Wu, L Marquez-Rosado, DB McElhinney, E Goldmuntz, C Liu, PD Lampe, B Chatterjee, CW Lo

Journal of Cardiovascular Disease Research (Elsevier) USA, China, 01 October 2011


Key words: Connexin43, congenital heart disease, gap junction, knock-in mouse model, outflow tract, phosphorylations

Organism: Mouse

Tissue: Heart

Pathological State: Heart disease

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice

Kristina M Mueller, Jan-Wilhelm Kornfeld, Katrin Friedbichler, Leander Blaas, Gerda Egger, Harald Esterbauer, Peter Hasselblatt, Michaela Schlederer, Susanne Haindl, Kay-Uwe Wagner, David Engblom, Guenter Haemmerle, Dagmar Kratky, Veronika Sexl, Lukas Kenner, Andrey V Kozlov, Luigi Terracciano, Rudolf Zechner, Guenther Schuetz, Emilio Casanova, J Andrew Pospisilik, Markus H Heim, Richard Moriggl

Hepatology (Wiley) Austria, Germany, USA, Sweden, Switzerland, 27 September 2011


Key words: Growth hormone (GH), peroxisome proliferator, systemic lipid homeostasis

Organism: Mouse

Tissue: Liver

Pathological State: Steatosis, Cancer

Soluble gp130 Regulates Prostate Cancer Invasion and Progression in an Interleukin-6 Dependent and Independent Manner

Shahrokh F Shariat, Thomas F Chromecki, Julia Hoefer, Christopher E Barbieri, Douglas S Scherr, Pierre I Karakiewicz, Claus G Roehrborn, Francesco Montoris, Zoran Culigd, Ilaria T Cavarretta

Journal of Urology (Elsevier) USA, Austria, Italy, Canada, 23 September 2011


Key words: Prostate, prostatic neoplasms, neoplasm invasiveness, cytokine receptor gp130, biological markers

Organism: Human

Pathological State: Cancer

Cell Line: Prostate stromal cells

Angiopoietin-Like 4 Regulates Epidermal Differentiation

Mintu Pal, Ming Jie Tan, Royston-Luke Huang, Yan Yih Goh, Xiao Ling Wang, Mark Boon Yang Tang, Nguan Soon Tan

PLoS One (PLOS) Singapore, 22 September 2011


Key words: Keratinocytes, cell differentiation, epidermis, immunoblotting, biopsy, DNA transcription, messenger RNA, wound healing

Organism: Mouse

Tissue: Skin

Semantic Segmentation of Microscopic Images Using a Morphological Hierarchy

Cristian Smochina, Vasile Manta, Walter Kropatsch

Computer Analysis of Images and Patterns (Springer) Romania, Austria, 31 August 2011

Medical Image Analysis

Key words: Crypt segmentation, Morphological hierarchy, Biomedical imaging, Pathology, Microscopy

Organism: Human

Tissue: Small Intestine, Colon

Abstracts for the IFPA Meeting 2011

Placenta (Elsevier) Austria, 27 August 2011

Expression of the IGF Axis Is Decreased in Local Prostate Cancer but Enhanced after Benign Prostate Epithelial Differentiation and TGF-β Treatment

Petra Massoner, Michael Ladurner Rennau, Isabel Heidegger, Anita Kloss-Brandstätter, Monika Summerer, Eva Reichhart, Georg Schäfer, Helmut Klocker

The American Journal of Pathology (Elsevier) Austria, 26 August 2011


Key words: Insulin-like growth factor (IGF),

Organism: Human

Tissue: Prostate

Pathological State: Cancer

Higher infiltration by Th17 cells compared with regulatory T cells is associated with severe acute T-cell-mediated graft rejection

Byung Ha Chung, Hye Jwa Oh, Shang Guo Piao, In O Sun, Seok Hui Kang, Sun Ryoung Choi, Hoon Suk Park, Bum Soon Choi, Yeong Jin Choi, Cheol Whee Park, Yong-Soo Kim, Mi-La Cho and Chul Woo Yang

Experimental & Molecular Medicine (Nature) South Korea, 24 August 2011


Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation

Eva Teuling, Annika Bourgonje, Sven Veenje, Karen Thijssen, Jelle de Boer, Joeri van der Velde, Morris Swertz, Ellen Nollen

Plos Currents (PLOS) The Netherlands, 12 August 2011


Organism: Human

Cell Line: HEK293-cells

Spatiotemporal expression of SERPINE2 in the human placenta and its role in extravillous trophoblast migration and invasion

Schu-Rern Chern, Sheng-Hsiang Li, Chien-Ling Chiu, Hsiao-Ho Chang, Chih-Ping Chen, Edmund I Tsuen Chen

Reproductive Biology and Endocrinology (Springer) Taiwan, 02 August 2011

Reproductive Medicine

Key words: SERPINE2, plasminogen activator (PA) system, tissue remodeling, pregnancy, trophoblasts

Organism: Human

Tissue: Placenta

Herpesvirus Entry Mediator and Nectin-1 Mediate Herpes Simplex Virus 1 Infection of the Murine Cornea

Andrew H Karaba, Sarah J Kopp and Richard Longnecker

Journal of Virology (American Society for Microbiology) USA, 27 July 2011


Key words: Herpes, infection

Organism: Mouse

Tissue: Eye

Pathological State: Herpes simplex Infection

Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy

Jenny Yao, Xiumin Wu, Guanglei Zhuang, Ian M Kasman, Tobias Vogt, Vernon Phan, Masabumi Shibuya, Napoleone Ferrara, Carlos Bais

PNAS (PNAS) Japan, Italy, 12 July 2011


Key words: Stroma tyrosine, kinase placental growth, factor vascular, endothelial growth, factor angiogenesis

Kupffer cells support extramedullary erythropoiesis induced by nitrogen-containing bisphosphonate in splenectomized mice

Hirotada Otsuka, Hideki Yagi, Yasuo Endo, Naoko Nonaka, Masanori Nakamura

Cellular Immunology (Elsevier) Japan, 05 July 2011


Key words: Nitrogen-containing bisphosphonate (NBP), Kupffer cell, Extramedullary erythropoiesis

Organism: Mouse

Tissue: Liver, Bone

Modeling Colon Adenocarcinomas in Vitro: A 3D Co-Culture System Induces Cancer-Relevant Pathways upon Tumor Cell and Stromal Fibroblast Interaction

Helmut Dolznig, Christian Rupp, Christina Puri, Christian Haslinger, Norbert Schweifer, Elisabeth Wieser, Dontscho Kerjaschki, Pilar Garin-Chesa

The American Journal of Pathology (Elsevier) Austria, 01 July 2011


Key words: Colon adenocarcinoma, in vitro

Organism: Human

Pathological State: Cancer

Cell Line: Cancer-associated fibroblasts

The Presence and Localization of Melatonin Receptors in the Rat Aorta

Martin Schepelmann, Lubos Molcan, Hana Uhrova, Michal Zeman, Isabella Ellinger

Cellular and Molecular Neurobiology (Springer) Austria, Slovakia, 22 June 2011


Key words: Mt1 receptor, saponin, arterial stiffness, melatonin concentration, rhythmic gene expression, rat eyerenal artery, clock gene bmal1, nadph oxidase, pineal gland, nocturnal hypertension

Organism: Rat

Tissue: Blood Vessels

FTY720 Reduces Post-Ischemic Brain Lymphocyte Influx but Does Not Improve Outcome in Permanent Murine Cerebral Ischemia

Arthur Lie, Li Sun, Wei Zhou, Sönke Schwarting, Eva Mracsko, Markus Zorn, Henrike Bauer, Clemens Sommer, Roland Veltkamp

PLoS One (PLOS) Germany, 20 June 2011


Key words: Ischemic strok e, Cerebral ischemia, Lymphocytes, Cytokines, T cells, Granulocytes, White blood cells, Monocytes

An rhs gene of Pseudomonas aeruginosa encodes a virulence protein that activates the inflammasome

Vanderlene L Kung, Sonal Khare, Christian Stehlik, Elizabeth M Bacon, Ami J Hughes, Alan R Hauser

PNAS (PNAS) USA, 09 June 2011


Key words: Rhs element, YD repeat, pathogenesis

Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells

Kihyun Lee, Hee Yeon Won, Myung Ae Bae, Jeong-Ho Hong, Eun Sook Hwang

PNAS (PNAS) South Korea, 07 June 2011


Key words: Rheumatoid arthritis myeloid-derived suppressor cell

Vasculatures in Tumors Growing From Preirradiated Tissues: Formed by Vasculogenesis and Resistant to Radiation and Antiangiogenic Therapy

Fang-Hsin Chen, Chi-Shiun Chiang, Chun-Chieh Wang, Sheng-Yung Fu, Chien-Sheng Tsai, Shih-Ming Jung, Chih-Jen Wen, Chung-Chi Lee, Ji-Hong Hong

International Journal of Radiation Oncology*Biology*Physics (Elsevier) Taiwan, 27 May 2011


Key words: Radiation, Tumor bed effects, Microvascular density, Green fluorescent protein–tagged bone marrow, Antiangiogenic therapy

Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

Yvonne Dombrowski, Mark Peric, Sarah Koglin, Claudia Kammerbauer, Christine Göß, David Anz, Maren Simanski, Regine Gläser, Jürgen Harder, Veit Hornung, Richard L Gallo, Thomas Ruzicka, Robert Beschand, Jürgen Schauber

Science Translational Medicine (American Association for the Advancement of Science) Germany, USA, 11 May 2011


Key words: Psoriasis, keratinocytes, antimicrobial cathelicidin peptide LL-37,

Influence of melatonin on murine osteoclast formation in culture — Automated detection and quantification by a novel image analysis system

M Schepelmann, A Heindl, A Seewald, A Nussbaumer, G Bises, R Rogojanu, P Pietschmann, I Ellinger, T Thalhammer

Bone (Elsevier) Austria, 07 May 2011

Medical Image Analysis

Automated detection, quantification and characterization of osteoclasts in cultures using a combined image-processing and machine-learning strategy

A Heindl, M Schepelmann, R Stumberger, A Nussbaumer, c, P Pietschmann, G Bisesa, R Rogojanu, d, T Thalhammer, A Seewald, I Ellinger

Bone (Elsevier) Austria, 07 May 2011

Medical Image Analysis

Key words: Osteoclasts

The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer

Katrin Wlcek, Martin Svoboda, Juliane Riha, Susanna Zakaria, Ulrike Olszewski, Zdenek Dvorak, Franz Sellner, Isabella Ellinger, Walter Jäger, Theresia Thalhammer

Cancer Biology and Therapy (Taylor and Francis) Austria, 01 May 2011


Key words: Polypeptides, cholangiocellular carcinoma, hepatocellular carcinoma

Segmentation of cell nuclei within chained structures in microscopic images of colon sections

C Smochina, A Serban, V Manta

Proceedings of the 27th Spring Conference on Computer Graphics (Association for Computing Machinery) Romania, 30 April 2011

Medical Image Analysis

Key words: Image segmentation, biomedical imaging, nucleus segmentation.

Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis

Sotlar K, Cerny-Reiterer S, Petat-Dutter K, Hessel H, Berezowska S, Müllauer L, Valent P, Horny HP

Modern Pathology (NCBI) Germany, 24 April 2011


Key words: Neoplastic mast cells, mastocytosis, reactive mast cell hyperplasia


C Saitta, T Pollicino, G Raffa, A Bertuccio, A Barbera, A Ciancio, A Smedile, G Navarra, G Raimondo

Journal of Hepatology (Elsevier) Italy, 18 April 2011


Pathological State: Cancer


A Pelc, K Roos, M Meinhard, H Mundt, B Besenbeck, H Schulze-Bergkamen, W Stremmel, M Müller

Journal of Hepatology (Elsevier) Germany, 18 April 2011



N Rohr-Udilova, W Sieghart, R Eferl, M Peck-Radosavljevic

Journal of Hepatology (Elsevier) , 18 April 2011

Transplantation Medicine


V Salvatore, M Baron Toaldo, S Marinelli, C Palamà, L Gramantieri, M Cipone, L Bolondi, F Piscaglia

Journal of Hepatology (Elsevier) Italy, 18 April 2011


Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF-β

Jennifer Lohr, Thomas Ratliff, Andrea Huppertz, Yingzi Ge, Christine Dictus, Rezvan Ahmadi, Stefan Grau, Nobuyoshi Hiraoka, Volker Eckstein, Rupert C Ecker, Thomas Korff, Andreas von Deimling, Andreas Unterberg, Philipp Beckhove, Christel Herold-Mende

Clinical Cancer Research (AACR Publications) Germany, 08 April 2011


Key words: Tumor, flow citometry

Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets

Kounnis V, Ioachim E, Svoboda M, Tzakos A, Sainis I, Thalhammer T, Steiner G, Briasoulis E

OncoTargets and Therapy (Dove Press) Greece, Austria, 08 April 2011


Key words: organic anion-transporting polypeptides, targeted therapy, transporter

Effect of Additional Boron on Tibias of African Ostrich Chicks

Jiayue Cheng, Kemei Peng, Erhui Jin, Yong Zhang, Yan Liu, Ningbo Zhang, Hui Song, Huazhen Liu, Zhonglin Tang

Biological Trace Element Research (Springer) China, 02 April 2011

Biological Materials

Key words: Ostrich chick, cortical bone thickness, bone volume fraction, boron intake, trabecular bone microarchitecture, boron addition, ovx rat, boron content, dietary boron bone strength, calcium phosphate, bone turnover, drinking water, bone mass

SERPINE2, an inhibitor of plasminogen activators, is highly expressed in the human endometrium during the secretory phase

Robert Kuo-Kuang Lee, Chi-Chen Fan, Yuh-Ming Hwu, Chung-Hao Lu, Ming-Huei Lin, Ying-Jie Chen, Sheng-Hsiang Li

Reproductive Biology and Endocrinology (Springer) Taiwan, 23 March 2011

Reproductive Medicine

Key words: protease nexin-1, plasminogen activators (PAs), SERPIN inhibitors, menstrual cycle

Hypoxia promotes proliferation of human myogenic satellite cells: a potential benefactor in tissue engineering of skeletal muscle

Merel Koning, Paul MN Werker, Marja JA van Luyn, and Martin C Harmsen

Tissue Engineering Part A (Mary Ann Liebert Inc.) The Netherlands, 23 March 2011

Regenerative Medicine

Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA, CEACAM) families, but striking identity of the CEA receptors will impact …

Marlene Weichselbaumer, Michael Willmann, Martin Reifinger, Josef Singer, Erika Bajna, Yuriy Sobanov, Diana Mechtcherikova, Edgar Selzer, Johann G Thalhammer, Robert Kammerer, Erika Jensen-Jarolim

Plos Currents (PLOS) Austria, Germany, 16 March 2011


Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2-: H2O2 Ratio and Confers Anoikis Resistance to Tumors

Pengcheng Zhu, Ming Jie Tan, Royston-Luke Huang, Chek Kun Tan, Han Chung Chong, Mintu Pal, Chee Ren Ivan Lam, Petra Boukamp, Jiun Yit Pan, Suat Hoon Tan, Sander Kersten, Hoi Yeung Li, Jeak Ling Ding, and Nguan Soon Tan

Cancer Cell (Cell Press) Singapore, 14 March 2011


Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages

Anne-Marie Kuhn, Nico Tzieply, Martina Victoria Schmidt, Andreas von Knethen, Dmitry Namgaladze, Masayuki Yamamoto, Bernhard Brüne

Free Radical Biology and Medicine (Elsevier) Germany, Japan, 05 March 2011


Key words: Foam cell, OxLDL, Nrf2, C/EBP, Desensitized phagocytes, Free radicals

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

Shilpee Dutt, Anupama Narla, Katherine Lin, Ann Mullally, Nirmalee Abayasekara, Christine Megerdichian, Frederick H Wilson, Treeve Currie, Arati Khanna-Gupta, Nancy Berliner, Jeffery L Kutok, Benjamin L Ebert

Blood (American Society of Hematology) USA, 03 March 2011


Key words: Flow citometry, cell cycle analysis

Mast Cell 5-Lipoxygenase Activity Promotes Intestinal Polyposis in APCΔ468 Mice

Eric C Cheon, Khashayarsha Khazaie, Mohammad W Khan, Matthew J Strouch, Seth B Krantz, Joseph Phillips, Nichole R Blatner, Laura M Hix, Ming Zhang, Kristen L Dennis, Mohammed R Salabat, Michael Heiferman, Paul J Grippo, Hidayatullah G Munshi, Elias Gounaris, David J Bentrem

Cancer Research (AACR Publications) USA, 01 March 2011


Key words: Arachidonic acid metabolism, colon carcinogenesis, hematopoietic 5-lipoxygenase (5LO), myeloid-derived suppressor cells (MDSCs)

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

Arthur Liesz, Wei Zhou, Éva Mracskó, Simone Karcher, Henrike Bauer, Sönke Schwarting, Li Sun, Dunja Bruder, Sabine Stegemann, Adelheid Cerwenka, Clemens Sommer, Alexander H Dalpke, Roland Veltkamp

Brain (Oxford University Press) Germany, 25 February 2011


Key words: Brain ischaemia, T cellVLA-4VCAM-1, inflammation

In Vitro Dedifferentiation of Melanocytes from Adult Epidermis

Bernadett Kormos, Nóra Bels, Attila Bebes, Gábor Szabad, Sarolta Bacsa, Márta Széll, Lajos Kemény, Zsuzsanna Bata-Csörg

PLoS One (PLOS) Hungary, 23 February 2011


Key words: Melanocyts, Ultraviolet, Keratinocytes, Nestin, Cell differentiation, Protein expression, Adults, Epidermis

Single chain anti-c-Met antibody conjugated nanoparticles for in vivo tumor-targeted imaging and drug delivery

Ruei-Min Lu, Yu-Ling Chang, Min-Shan Chen, Han-Chung Wu

Biomaterials (Elsevier) Taiwan, 08 February 2011

Medical Imaging

Key words: c-Met, Phage display, scFv, Drug delivery system, Immunoliposome

Pathological State: Cancer

Adeno-associated virus-mediated anti-DR5 chimeric antibody expression suppresses human tumor growth in nude mice

Fujia Lv, Yuhe Qiu, Yaxi Zhang, Shilian Liu, Juan Shi, Yanxin Liu, Dexian Zheng

Cancer Letters (Elsevier) China, 08 February 2011


Key words: Chimeric antibody, Death receptor 5, Gene transfer, Cancer therapy

Clinical and Cytological Effects of Pimecrolimus Cream 1% after Resolution of Active Atopic Dermatitis Lesions by Topical Corticosteroids: A Randomized Controlled Trial

Bangert C, Strober BE, Cork M, Ortonne J-P, Luger T, Bieber T, Ferguson A, Ecker RC, Kopp T, Weise-Riccardi S, Guettner A, Stingl G

Dermatology (Karger) Austria, USA, UK, France, Germany, 01 February 2011


Key words: Skin biopsies, dendritic cells, Langerhans cells, T cells, betamethasone-17α-valerate-induced AD

Irreversible electroporation in the liver: contrast-enhanced inversion-recovery MR imaging approaches to differentiate reversibly electroporated penumbra from Irreversibly Electroporated Ablation Zones

Yang Guo, Yue Zhang, Grace M Nijm, Alan V Sahakian, Guang-Yu Yang, Reed A Omary, Andrew C Larson

Radiology (Radiological Society of North America) USA, 01 February 2011


α-Catulin knockdown induces senescence in cancer cells

LC Fan, WF Chiang, CH Liang, YT Tsai, TY Wong, KC Chen, TM Hong, YL Chen

Oncogene (Nature) Taiwan, 31 January 2011


Key words: Cancer, Gene regulation, Oncogenesis, Senescence

Entry of a heparan sulphate-binding HRV8 variant strictly depends on dynamin but not on clathrin, caveolin, and flotillin

Abdul Ghafoor Khan, Angela Pickl-Herk, Leszek Gajdzik, Thomas C Marlovits, Renate Fuchs, Dieter Blaas

Virology (Elsevier) Austria, 22 January 2011


Key words: Rhinovirus, Endocytosis, Dynamin, Macropinocytosis, Entry inhibitors, Endocytic pathway, Heparan sulphate, ICAM-1, Clathrin

Perifosine and CCI 779 Co-Operate to Induce Cell Death and Decrease Proliferation in PTEN-Intact and PTEN-Deficient PDGF-Driven Murine Glioblastoma

Kenneth L Pitter, Craig J Galbán, Stefanie Galbán, Omid Saeed-Tehrani, Fei Li, Nikki Charles, Michelle S Bradbury, Oren J Becher, Thomas L Chenevert, Alnawaz Rehemtulla, Brian D Ross, Eric C Holland, Dolores Hambardzumyan

PLoS One (PLOS) USA, 18 January 2011


Key words: Glioma, Magnetic resonance imaging, Glioma cells, Adenocarcinomas, Cell death, In vivo imaging, Apoptosis

Detection of Nucleated Red Blood Cells in Maternal Circulation by Magnetic Sorting and in situ Hybridization

D Nemescu, D Constantinescu, V Martiniuc…

Gineco+ro () Romania, 01 January 2011

Reproductive Medicine

Key words: prenatal diagnosis, erythroblast, CD71, magnetic-activated cell sorting (MACS), flu o res cent in situ hybridization (FISH)

Novel Molecular Strategy Tests, Issued by Laparoscopy, That Can Predict the Progression and Severity of Endometriotic Disease

JB de la Joliniere, G Lesec, C Real, JM Ayoubi

Journal of Minimally Invasive Gynecology (AAGL) France, 01 January 2011

Reproductive Medicine

Enhanced sensitivity to Botulinum type A neurotoxin of human neuroblastoma SH-SY5Y cells after differentiation into mature neuronal cells

C Rasetti-Escargueil, CB Machado, R Preneta-Blanc

The Botulinum Journal (InderScience Publishers) UK, 01 January 2011


Key words: BoNT, Botulinum neurotoxin, neurotransmitter release, SH-SY5Y cell line, human neuroblastoma cells, differentiation, cell based assay, synaptic vesicles recycling.

Principles of Osteoimmunology

P Pietschmann

Principles of Osteoimmunology (Springer) Austria, 01 January 2011



Goian, L, Veliceasa, B, Tărniceriu, Cristina Claudia, Frâncu, L L

Romanian Journal of Functional and Clinical, Macro- and Microscopical Anatomy and of Anthropology () Romania, 01 January 2011



L Goian, CC Tărniceriu, LL Francu

Romanian Journal of Functional and Clinical, Macro- and Microscopical Anatomy and of Anthropology () Romania, 01 January 2011


Multifunctional hollow nanoparticles based on graft-diblock copolymers for doxorubicin delivery

Pei-Lin Lu, Yi-Chun Chen,Ta-Wei Ou, Hung-Hao Chen, Hsieh-Chih Tsai, Chih-Jen Wen, Chun-Liang Lo, Shiaw-Pyng Wey, Kun-Ju Lin,Tzu-Chen Yen, Ging-Ho Hsiu

Biomaterials (Elsevier) Taiwan, 22 December 2010

Biological Materials

Key words: Multifunctional hollow nanoparticles, Intracellular drug delivery, Cancer targeting, SPECT/CT imaging, Cancer therapy

Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans

Sabine Lagger, Dominique Meunier, Mario Mikula, Reinhard Brunmeir, Michaela Schlederer, Matthias Artaker, Oliver Pusch, Gerda Egger, Astrid Hagelkruys, Wolfgang Mikulits, Georg Weitzer, Ernst W Muellner, Martin Susani, Lukas Kenner, Christian Seiser

EMBO Journal (EMBO Press) Austria, 20 December 2010


Key words: Cancer treatment chromatinepigeneticsHDAC inhibitorshistone modifications

Lysophosphatidylcholine‐mediated functional inactivation of syndecan‐4 results in decreased adhesion and motility of dendritic cells

Johannes Bühligen, Mirko Himmel, Carl Gebhardt, Jan C Simon, Wolfgang Ziegler, Marco Averbeck

Journal of Cellular Physiology (Wiley) Germany, 15 December 2010

Cell Biology

Loss of ATM/Chk2/p53 Pathway Components Accelerates Tumor Development and Contributes to Radiation Resistance in Gliomas

Massimo Squatrito, Cameron W Brennan, Karim Helmy, Jason T Huse, John H Petrini, Eric C Holland

Cancer Cell (Cell Press) USA, 13 December 2010


Key words: Glioblastoma mutliforme, DNA-damage response, ionizing radiation in vivo

Somatic Mutations throughout the Entire Mitochondrial Genome Are Associated with Elevated PSA Levels in Prostate Cancer Patients

Anita Kloss-Brandstätter, Georg Schäfer, Gertraud Erhart, Alexander Hüttenhofer, Stefan Coassin, Christof Seifarth, Monika Summerer, Jasmin Bektic, Helmut Klocker, Florian Kronenberg

American Journal of Human Genetics (Elsevier) Austria, 02 December 2010


Key words: Somatic mitochondrial DNA (mtDNA) mutations, mitochondrial genes MT-CO2, MT-CO3, MT-ATP6, and MT-ND6, human mitochondrial genome

Neuronal hyperexcitability and seizures are associated with changes in glial–neuronal interactions in the hippocampus of a mouse model of epilepsy with mental retardation

Torun Melø, Paolo Bigini, Ursula Sonnewald, Silvia Balosso, Alfredo Cagnotto, Sara Barbera, Sarah Uboldi, Annamaria Vezzani, Tiziana Mennini

Journal of Neurochemistry (Wiley) Norway, Italy, 19 November 2010


Key words: 13C nuclear magnetic resonance spectroscopy, astrocytes and microglia, glutamate and GABA, hippocampus, neuronal ceroid lipofuscinosis, seizures

Semi-automatic identification of punching areas for tissue microarray building: the tubular breast cancer pilot study

Federica Viti, Ivan Merelli, Mieke Timmermans, Michael den Bakker, Francesco Beltrame, Peter Riegman, Luciano Milanesi

BMC Bioinformatics (Springer) Italy, The Netherlands, 18 November 2010

Medical Image Analysis

Key words: Pixel Intensity, Pathological Region, Virtual Microscope, Donor Block, Unaffected Area

Nuclear localization of Nm23-H1 in head and neck squamous cell carcinoma is associated with radiation resistance

Haeng Ran Park, Se-Heon Kim, Sei Young Lee, Ji Min Sung, Ae Ran Park, Suki Kang, Baek Gil Kim, Yoon Pyo Choi, Yong-Bae Kim, Nam Hoon Cho

Cancer (Wiley) South Korea, 18 November 2010


Key words: Nm23-H1, nuclear localization, radiation resistance, head and neck squamous cell carcinoma, predictor

Standards and impact of hematopathology in myelodysplastic syndromes (MDS)

Peter Valent, Attilio Orazi, Guntram Büsche, Annette Schmitt-Gräff, Tracy I George, Karl Sotlar, Berthold Streubel, Christine Beham-Schmid, Sabine Cerny-Reiterer, Otto Krieger, Arjan van de Loosdrecht, Wolfgang Kern, Kiyoyuki Ogata, Friedrich Wimazal, Judit Csomor, Judit Varkonyi, Wolfgang R Sperr, Martin Werner, Hans Kreipe, Horny Hans-Peter

Oncotarget (Impact Journals) Austria, Germany, Hungary, USA, Japan, The Netherlands, 16 November 2010


Key words: MDS, hematopathology, diagnostic criteria, prognostication

p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons

An-Hsun Chou, An-Chi Lin, Kue-Yi Hong, Su-Huei Hu, Ying-Ling Chen, Ju-Yu Chen, Hung-Li Wang

Neurochemistry International (Elsevier) Taiwan, 16 November 2010


Key words: Spinocerebellar ataxia type 3, Polyglutamine-expanded ataxin-3, Cerebellum, Pontine nuclei, Bax,

The role of collagen receptors Endo180 and DDR-2 in the foreign body reaction against non-crosslinked collagen and gelatin

Qingsong Ye, Martin C Harmsen, Yijin Ren, Ruud A Bank

Biomaterials (Elsevier) The Netherlands, China, Australia, 10 November 2010

Biological Materials

Key words: Collagen, Gelatin, Endo180, DDR-2, Foreign body reaction, Giant cells

Highly malignant intra-hepatic metastatic hepatocellular carcinoma in rats

Y Guo, R Klein, RA Omary, GY Yang, AC Larson

American Journal of Translational Research (e-Century Publishing Corporation) USA, 01 November 2010


Key words: Hepatocellular carcinoma (HCC), rodent model, orthotopic implantation, N1-S1 rat HCC cell line, McARH7777 rat HCC cell line, MRI, histopathology

Spatiotemporal expression of the serine protease inhibitor, SERPINE2, in the mouse placenta and uterus during the estrous cycle, pregnancy, and lactation

Schu-Rern Chern, Sheng-Hsiang Li, Chung-Hao Lu, Edmund I Tsuen Chen

Reproductive Biology and Endocrinology (Springer) Taiwan, 27 October 2010

Reproductive Medicine

Key words: Estrous Cycle, Mouse Uterus, Trophoblast Giant Cell, Pregnant Uterus, Ectoplacental Cone

The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection

Huajie Bu, Stefanie Bormann, Georg Schäfer, Wolfgang Horninger, Petra Massoner, Antje Neeb, Vinoth-Kumar Lakshmanan, Danilo Maddalo, Andrea Nestl, Holger Sültmann, Andrew CB Cato, Helmut Klocker

The Prostate (Wiley) Austria, Germany, 13 October 2010


Key words: Urine prostate cancer marker, cell migration, cell-cycle progression, invasion, metastasis

Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid

Mansour Mohamadzadeh, Erika A Pfeiler, Jeffrey B Brown, Mojgan Zadeh, Matthew Gramarossa, Elizabeth Managlia, Praveen Bere, Bara Sarraj, Mohammad W Khan, Krishna Chaitanya Pakanati, M Javeed Ansari, Sarah O'Flaherty, Terrence Barrett, Todd R Klaenhammer

PNAS (PNAS) USA, 12 October 2010

Immunology, Microbiology

Key words: Antiinflammatory lactobacilli Toll-like receptor 2 innate immunity


Anticancer Research (Anticancer Research) Greece, 10 October 2010


Key words: Antitumor lymphocytes, ES cells, bioluminiscence imaging

Endo180 and MT1-MMP are involved in the phagocytosis of collagen scaffolds by macrophages and is regulated by interferon-gamma

Ye Q, Xing Q, Ren Y, Harmsen MC, Bank RA

European Cells and Materials (NCBI) The Netherlands, 07 October 2010

Regenerative Medicine

Key words: Hexamethylenediisocyanate, glutaraldehyde cross-linked sheep collagen,

Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

Tatsuaki Mizutani, Nina Neugebauer, Eva M Putz, Nadine Moritz, Olivia Simma, Eva Zebedin-Brandl, Dagmar Gotthardt, Wolfgang Warsch, Eva Eckelhart, Hans-Peter Kantner, Ulrich Kalinke, Stefan Lienenklaus, Siegfried Weiss, Birgit Strobl, Mathias Müller, Veronika Sexl, Dagmar Stoiber

OncoImmunology (Taylor and Francis) Austria, Germany, 01 October 2010


Key words: IFNAR1, IFNß, NK cells, leukemia, tumor surveillance

Transcriptional coactivators p300 and CBP stimulate estrogen receptor-beta signaling and regulate cellular events in prostate cancer

Jan Bouchal, Frédéric R Santer, Philipp PS Höschele, Eva Tomastikova, Hannes Neuwirt, Zoran Culig

The Prostate (Wiley) Austria, Czech Republic, 21 September 2010


Key words: Transcriptional coactivators, prostate cancer, estrogen receptor-ß, migration, genistein

Physicochemical characterization and in vivo bioluminescence imaging of nanostructured lipid carriers for targeting the brain: apomorphine as a model drug

Shu-Hui Hsu, Chih-Jen Wen, S A Al-Suwayeh, Hui-Wen Chang, Tzu-Chen Yen, Jia-You Fang

Nanotechnology (IOP Science) Taiwan, 08 September 2010


Key words: Drug administration, Fluorescence microscopy, Drug release, Nuclear magnetic resonance, Brain Aqueous solutions, Saline Particle size, Transmission electron microscopy, Fluorescence, Nanoparticles Water Bioluminescence

Towards a versatile automated cell-detection system for science and diagnostics

Heindl, A, Dekan, S, Ellinger, I, Seewald, AK

Engineering in Medicine and Biology Society (IEEEXplore) Austria, 04 September 2010

Medical Image Analysis

Key words: Pixel, Proteins, Algorithm design and analysis, Histograms, Microscopy, Software tools

Self-assembling peptide amphiphile promotes plasticity of serotonergic fibers following spinal cord injury

Vicki M Tysseling, Vibhu Sahni, Eugene T Pashuck, Derin Birch, Amy Hebert, Catherine Czeisler, Samuel I Stupp, John A Kessler

Journal of Neuroscience Research (Wiley) USA, 03 September 2010


Key words: Spinal cord injury, nanotechnology, biomaterials, regeneration, serotonin

Pathological State: Spinal Cord Injury

TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

Zhan Yao, Silvia Fenoglio, Ding Cheng Gao, Matthew Camiolo, Brendon Stiles, Trine Lindsted, Michaela Schlederer, Chris Johns, Nasser Altorki, Vivek Mittal, Lukas Kenner, Raffaella Sordella

PNAS (PNAS) USA, 31 August 2010


Key words: Epidermal growth-factor receptor nonsmall cell lung cancer

Segmentation of cell nuclei within complex configurations in images with colon sections

Rogojanu, R, Bises, G, Smochina, C, Manta, V

Intelligent Computer Communication and Processing (IEEEXplore) Austria, Romania, 28 August 2010

Medical Image Analysis

Key words: Nuclei segmentation

MR imaging to assess immediate response to irreversible electroporation for targeted ablation of liver tissues: preclinical feasibility studies in a rodent model

Yue Zhang, Yang Guo, Ann B Ragin, Robert J Lewandowski, Guang-Yu Yang, Grace M Nijm, Alan V Sahakian, Reed A Omary, Andrew C Larson

Radiology (Radiological Society of North America) USA, 01 August 2010

Biological Methods

Tissue Microarrays in Cancer Research

Toby C Cornish, Angelo M De Marzo

Modern Molecular Biology (Springer) USA, 29 July 2010


Key words: Tissue microarrays, formalin fixed, paraffin embedded tissue

Automated Analysis of Tissue Microarrays

Marisa Dolled-Filhart, Mark Gustavson, Robert L Camp, David L Rimm, John L Tonkinson, Jason Christiansen

Tissue Microarrays (Springer) USA, 21 July 2010

Medical Image Analysis

Key words: Immunohistochemistry, Automated analysis, AQUA, Tissue microarrays, Quantitative analysis, Biomarkers, Immunofluorescence

Neurons and Neuronal Stem Cells Survive in Glucose-Free Lactate and in High Glucose Cell Culture Medium During Normoxia and Anoxia

Sascha Wohnsland, Heinrich F Bürgers, Wolfgang Kuschinsky, Martin H Maurer

Neurochemical Research (Springer) Germany, Austria, 03 July 2010


Key words: Global cerebral ischemia, hippocampal slice culture, glucose group, normoxic group, lactate concentration, organotypic slice culture, neuronal cell death, glucose deprivation, papain, neural progenitor cell, brain lactate, ketone body, iodide uptake, cortical neuron, rat pup

419 V600EB-RAF cooperates in Epithelial to Mesenquimal Transition regulating E-Cadherin and ILK-1 expression through the MEK/ERK-MAPK pathway

P Baquero, I Sánchez-Hernández, A Chiloeches

European Journal of Cancer (Elsevier) , 28 June 2010


418 Differences in radiation, cisplatin, and cetuximab sensitivity between subpopulations of head and neck cancer cells

C Nilsson, L La Fleur, K Roberg

European Journal of Cancer (Elsevier) , 28 June 2010


417 A c-Myc induced gene expression signature in human germinal center B cells predicts subtypes of aggressive non-Hodgkin Lymphoma

A Schrader, S Bentink, R Spang, D Lenze, M Hummel, M Kuo, P Murray, L Trümper, D Kube, M Vockerodt

European Journal of Cancer (Elsevier) , 28 June 2010


416 Characterization and quantification of macrophages in colorectal cancer by an automated cell system

R Rogojanu, I Mesteri, I Ellinger, T Talhammer, E Kallay, A Heindl, A Seewald, G Bises

European Journal of Cancer (Elsevier) Austria, 28 June 2010

Medical Image Analysis

A Rat Model for Pressure Induced Deep Tissue Injury

Fang Lin, Mauli Modi, Briana Reprogle, Mike Bajema, Ziyan Wang, Gordon Kaskin, Mohsen Makhsous

ASME 2010 Summer Bioengineering Conference (ASME) USA, 16 June 2010

Biological Methods

Key words: Pressure, Biological tissues, Wounds

An advanced approach for the characterization of dendritic cell-induced T cell proliferation in situ

Christian Florian, Thomas Barth, Anja K Wege, Daniela N Männel, Uwe Ritter

Immunobiology (Elsevier) Germany, 09 June 2010


Key words: BrdU incorporation, fluorochromes, lymph node, proliferation, T cells, TissueQuest

Neuropathologic and Biochemical Changes During Disease Progression in Liver X Receptor B_/_ Mice, A Model of Adult Neuron Disease

P Bigini, KR Steffensen, A Ferrario, L Diomede

Journal of Neuropathology and Experimental Neurology (American Association of Neuropathologists) USA, 01 June 2010


Key words: Amytrophic lateral sclerosis, Cholesterol, CNS Inflammation, Glial cells, Liver X receptors, Motor neurons, Spinal neurons

Pathological State: Amyotrophic lateral sclerosis

Neuropathologic and Biochemical Changes During Disease Progression in Liver X Receptor β−/− Mice, A Model of Adult Neuron Disease

Paolo Bigini, Knut R Steffensen, Anna Ferrario, Luisa Diomede, Giovanni Ferrara, Sara Barbera, Sonia Salzano, Elena Fumagalli, Pietro Ghezzi, Tiziana Mennini, Jan-Åke Gustafsson

Journal of Neuropathology and Experimental Neurology (Oxford University Press) USA, 01 June 2010


Key words: Amyotrophic lateral sclerosis, Cholesterol, CNS inflammation, Glial cells, Liver X receptors, Motor neurons, Spinal neurons

Pathological State: Amyotrophic lateral sclerosis

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Frank Weinberg, Robert Hamanaka, William W Wheaton, Samuel Weinberg, Joy Joseph, Marcos Lopez, Balaraman Kalyanaraman, Gökhan M Mutlu, G R Scott Budinger, Navdeep S Chandel

PNAS (PNAS) USA, 11 May 2010


Key words: Warburg Effect glutamine glycolysis lung cancer complex III

Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

Benelita Tina Elie, Vasilena Gocheva, Tanaya Shree, Stacie A Dalrymple, Leslie J Holsinger, Johanna A Joyce

Biochimie (Elsevier) USA, 04 May 2010


Key words: Cancer, Cysteine cathepsin, Protease, Therapy

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

Prakash G Chandak, Branislav Radovic, Elma Aflaki, Dagmar Kolb, Marlene Buchebner, Eleonore Fröhlich, Christoph Magnes, Frank Sinner, Guenter Haemmerle, Rudolf Zechner, Ira Taba, Sanja Levak-Fran, Dagmar Kratky

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) Austria, USA, 27 April 2010

Cell Biology

Key words: ATP, Fatty Acid, Metabolism Glucose Lipase Lipid, Droplet Macrophage, Phagocytosis, Triacylglycerol

Automated segmentation of tissue images for computerized IHC analysis

S Di Cataldo, E Ficarra, A Acquaviva, E Macii

Computer Methods and Programs in Biomedicine (Elsevier) Italy, 01 April 2010

Medical Image Analysis

Key words: Immunohistochemistry, Tissue images, Tissue segmentation, Nuclear segmentation, Image processing

Rapid Pharmacokinetic and Biodistribution Studies Using Cholorotoxin-Conjugated Iron Oxide Nanoparticles: A Novel Non-Radioactive Method

Michelle Jeung-Eun Lee, Omid Veiseh, Narayan Bhattarai, Conroy Sun, Stacey J Hansen, Sally Ditzler, Sue Knoblaugh, Donghoon Lee, Richard Ellenbogen, Miqin Zhang, James M Olson

PLoS One (PLOS) USA, 04 March 2010

Medical Imaging

Key words: Nanoparticles, Spleen, Fluorescence imaging, Kidneys, Pharmacokinetics, Liver, Bone marrow, Iron oxides

Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing Cholangitis

Markus Mair, Gernot Zollner, Doris Schneller, Monica Mustean, Peter Fickert Judith Gumhol, Christian Schuste, Andrea Fuchsbichler, Martin Bilban, Stefanie Tauber, Harald Esterbauer, Lukas Kenner, Valeria Poli, Leander Blaas, Jan Wilhelm Kornfeld, Emilio Casanova, Wolfgang Mikulits, Michael Trauner, Robert Eferl

Gastroenterology (Elsevier) Austria, Germany, Italy, 26 February 2010


Key words: Stat3, Liver, Conditional Mouse Model, Cholestasis

Pathological State: Cholangitis

PI3Kγ Protects from Myocardial Ischemia and Reperfusion Injury through a Kinase-Independent Pathway

Bernhard J Haubner, G Gregory Neely, Jakob G J Voelkl, Federico Damilano, Keiji Kuba, Yumiko Imai, Vukoslav Komnenovic, Agnes Mayr, Otmar Pachinger, Emilio Hirsch, Josef M Penninger, Bernhard Metzler

PLoS One (PLOS) Austria, Italy, 22 February 2010


Key words: Reperfusion, Heart, Inflammation, Reperfusion injury, Infarction, Cardiac ventricles, Bone marrow cells, Bone marrow transplantation

Roles of hypoxia-inducible factor-1α (HIF-1α) versus HIF-2α in the survival of hepatocellular tumor spheroids

Heidi Menrad, Christian Werno, Tobias Schmid, Ekaterini Copanaki, Thomas Deller, Nathalie Dehne,Bernhard Brüne

Hepatology (Wiley) Germany, 19 February 2010


Key words: Hypoxia-inducible factors, hypoxic stress, tumor tissues, hepatocellular carcinoma, proapoptotic Bax

BMPR1a and BMPR1b Signaling Exert Opposing Effects on Gliosis after Spinal Cord Injury

Vibhu Sahni, Abhishek Mukhopadhyay, Vicki Tysseling, Amy Hebert, Derin Birch, Tammy L Mcguire, Samuel I Stupp, John A Kessler

Journal of Neuroscience (SFN) USA, 03 February 2010


Key words: Spinal cord injury, bone morphogenetic protein, Western blot analysis

Pathological State: Spinal Cord Injury

Human Rhinovirus 14 Enters Rhabdomyosarcoma Cells Expressing ICAM-1 by a Clathrin-, Caveolin-, and Flotillin-Independent Pathway

Abdul Ghafoor Khan, Angela Pickl-Herk, Leszek Gajdzik, Thomas C Marlovits, Renate Fuchs, Dieter Blaas

Journal of Virology (American Society for Microbiology) Austria, 03 February 2010


Key words: Rhynovirus

Neutralization of Osteopontin Inhibits Obesity-Induced Inflammation and Insulin Resistance

Florian W Kiefer, Maximilian Zeyda, Karina Gollinger, Birgit Pfau, Angelika Neuhofer, Thomas Weichhart, Marcus D Säemann, René Geyeregger, Michaela Schlederer, Lukas Kenner, Thomas M Stulnig

Diabetes (Diabetes Journals) Austria, 27 January 2010


Key words: Obesity, osteopontin, insulin sensitivity, fatty acid synthase (FAS), sterol regulatory element–binding protein-1c

Pathological State: Obesity

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

Vasilena Gocheva, Hao-Wei Wang, Bedrick B Gadea, Tanaya Shree, Karen E Hunter, Alfred L Garfall, Tara Berman, Johanna A Joyce

Genes and Development (CSH Press) USA, 15 January 2010


Key words: Tumor-associated macrophage, tumor microenvironment, cysteine cathepsin protease, interleukin-4 invasion

Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study

Satya Khuon, Luke Liang, Robert W Dettman, Peter H S Sporn, Robert B Wysolmerski, Teng-Leong Chew

Journal of Cell Science (The Company of Biologists) USA, 12 January 2010


Key words: FRET imaging, Cytoskeletal signaling, Endothelium, Transcellular invasion, Tumor intravasation, Vascular engineering

Management of recurrence of symptoms of gastroesophageal reflux disease: synergistic effect of rebamipide with5 mg lansoprazole

N Yoshida, K Kamada, N Tomatsuri, T Suzuki, T Takagi, H Ichikawa, T Yoshikawa

Digestive diseases and Sciences (Springer) , 01 January 2010

Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice

Lisa Sevenich, Uta Schurigt, Kathrin Sachse, Mieczyslaw Gajda, Fee Werner, Sebastian Müller, Olga Vasiljeva, Anne Schwinde, Nicole Klemm, Jan Deussing, Christoph Peters, Thomas Reinheckel

PNAS (PNAS) Germany, 22 December 2009


Key words: Lysosome mammary, adenocarcinoma, mouse model protease

In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium

Karin Montet-Abou, Jean-Luc Daire, Jean-Noël Hyacinthe, Manuel Jorge-Costa, Kerstin Grosdemange, François Mach, Alke Petri-Fink, Heinrich Hofmann, Denis R Morel, Jean-Paul Vallée, Xavier Montet

European Heart Journal (Oxford University Press) Switzerland, 19 December 2009


Key words: Magnetic resonance imaging, Iron oxide nanoparticles, Inflammation, Myocardial infarction

Carbogen Gas–Challenge BOLD MR Imaging in a Rat Model of Diethylnitrosamine-induced Liver Fibrosis

Ning Jin, Jie Deng, Tamuna Chadashvili, Yue Zhang, Yang Guo, Zhuoli Zhang, Guang-Yu Yang, Reed A Omary, Andrew C Larson

Radiology (Radiological Society of North America) USA, 14 December 2009


Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement

Alexander T Bauer, Heinrich F Bürgers, Tamer Rabie, Hugo H Marti

Journal of Cerebral Blood Flow and Metabolism (SAGE Journals) Germany, 09 December 2009


Key words: blood–brain barrier, hypoxia, in vivo, matrix metalloproteinase, occludin, vascular permeability

Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells

Frédéric R Santer, Kamilla Malinowska, Zoran Culig, Ilaria T Cavarretta

Endocrine-Related Cancer (Society for Endocrinology) Austria, 04 December 2009


Key words: IL-6 receptor, phosphotidylinositol 3-kinase, prostate cancer,

Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice

Monica Musteanu, Leander Blaas, Markus Mair, Michaela Schlederer, Martin Bilban Stefanie Tauber, Harald Esterbauer,Mathias Mueller, Emilio Casanova, Lukas Kenner, Valeria Poli, Robert Eferl

Gastroenterology (Elsevier) Austria, Italy, 04 December 2009


Key words: APC, CEACAM1, Colorectal Cancer

Mimotope vaccination for therapy of allergic asthma: anti-inflammatory effects in a mouse model

J Wallmann, MM Epstein, P Singh, R Brunner, K Szalay, L El-Housseini, I Pali-Scholl, E Jensen-Jarolim

Clinical and Experimental Allergy (Wiley) Austria, 02 December 2009

Allergy Research

Key words: T lymphocytes, grass pollen allergens, Keyhole limpet haemocyanin (KLH)

Disruption of the growth hormone—Signal transducer and activator of transcription 5—Insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis

Leander Blaas, Jan-Wilhelm Kornfeld, Daniel Schramek, Monica Musteanu, Gernot Zollner, Judith Gumhold, Franziska van Zijl, Doris Schneller, Harald Esterbauer, Gerda Egger, Markus Mair, Lukas Kenner, Wolfgang Mikulits, Robert Eferl, Richard Moriggl, Josef Penninger, Michael Trauner, Emilio Casanova

Hepatology (Wiley) Austria, 30 November 2009


Key words: Liver Failure, Cirrhosis, Portal Hypertension

Pathological State: Liver Fibrosis

Transient Protective Effect of B-Vitamins in Experimental Epilepsy in the Mouse Brain

Tamer Rabie, Wolfgang Mühlhofer, Thomas Bruckner, Anna Schwab, Alexander T Bauer, Manfred Zimmermann, Dieter Bonke, Hugo H Marti, Johannes Schenkel

Journal of Molecular Neuroscience (Springer) Germany, 24 September 2009


Key words: Kainate administration, bcl-2 mrna expression, pyridoxine, kainate injection, tunel-positive cell, neuronal cell death, hippocampal ca3 region, genomic dna methylation, bcl-2 protein, dentate gyrus, follicular lymphoma, glutamate receptor, cognitive dysfunction, dead cell, saline-treated mouse

Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling

Pamina Pflegerl, Paul Vesely, Brigitte Hantusch, Michaela Schlederer, Rainer Zenz, Elke Janig, Günter Steiner, Arabella Meixner, Peter Petzelbauer, Peter Wolf, Afschin Soleiman, Gerda Egger, Richard Moriggl, Tadamitsu Kishimoto, Erwin F Wagner, Lukas Kenner

PNAS (PNAS) Austria, Spain, Japan, 15 September 2009


Key words: Epidermis IL-6R systemic lupus erythematosus

The potential role of c-Jun activation in patients with cutaneous lichen planus

Zuzana Marceková, Michael J Flaig, Maja Kekuš, Thomas Ruzicka, Rudolf A Rupec

Experimental Dermatology (Wiley) Germany, 15 September 2009


Key words: C-Jun activation, immunohistochemistry, lichen planus, squamous cell carcinoma

Expression of sulfotransferases and sulfatases in human breast cancer: Impact on resveratrol metabolism

Michaela Miksits, Katrin Wlcek, Martin Svoboda, Theresia Thalhammer, Isabella Ellinger, Gabriele Stefanzl, Charles N Falany, Thomas Szekeres, Walter Jaeger

Cancer Letters (Elsevier) Austria, USA, 10 September 2009


Key words: Resveratrol, Sulfation, Breast cancer, SULTs, Sulfatases, PCR, Immunofluorescence

COP1 contributes to UVB-induced signaling in human keratinocytes

Agnes Kinyo, Zsuzsanna Kiss-Laszlo, Szabolcs Hambalko, Attila Bebes, Maria Kiss, Marta Szell, Zsuzsanna Bata-Csörgo, Ferenc Nagy, Lajos Kemeny

Journal of Investigative Dermatology (Elsevier) Hungary, UK, 10 September 2009


The relationship between collagen scaffold cross-linking agents and neutrophils in the foreign body reaction

Qingsong Ye, Martin C Harmsen, Marja JA van Luyn, Ruud A Bank

Biomaterials (Elsevier) The Netherlands, China, Australia, 09 September 2009

Regenerative Medicine

Key words: Matrix metalloproteinase, Foreign body reaction, Giant cell formation, Phagocytosis, Interferon-gamma, Neutrophils

Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways

Martin Puhr, Frédéric R Santer, Hannes Neuwirt, Martin Susani, Jeffrey A Nemeth, Alfred Hobisch, Lukas Kenner, Zoran Culig

Cancer Research (AACR Publications) Austria, USA, 08 September 2009


Key words: Prostate cancer suppressor of cytokine signaling apoptosis extrinsic and intrinsic pathways

Organizational Issues in Providing High-Quality Human Tissues and Clinical Information for the Support of Biomedical Research

Walter C Bell, Katherine C Sexton, William E Grizzle

Cancer Gene Profiling (Springer) USA, 06 August 2009


Key words: Human tissu, e Tissue banking, Tissue repository, Research infrastructure, IRB HIPAA

From virtual microscopy to systems pathology

Niels Grabe, Peter Schirmacher

Virchows Archiv (Springer) Germany, 04 August 2009


Vitamin D Analogs Differentially Control Antimicrobial Peptide/“Alarmin”Expression in Psoriasis

Mark Peric, Sarah Koglin, Yvonne Dombrowski, Katrin Groß, Eva Bradac, Amanda Büchau, Andreas Steinmeyer, Ulrich Zügel, Thomas Ruzicka, Jürgen Schauber

PLoS One (PLOS) Germany, 22 July 2009


Key words: Vitamin D, Keratinocytes, Psoriasis, Inflammation, ERK signaling cascade, Small interfering RNAs, Antimicrobials, Biopsy

Pathological State: Psoriasis

Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility

Petra Massoner, Daniela Colleselli, Andrea Matscheski, Haymo Pircher, Stephan Geley, Pidder Jansen Dürr, Helmut Klocker

Endocrine-Related Cancer (Bioscientifica) Austria, 09 June 2009


Key words: Prostate cancer, insulin-like growth factor (IGF), western-blot analysis

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

Andreas Weigert, Susanne Schiffmann, Divya Sekar, Stephanie Ley, Heidi Menrad, Christian Werno, Sabine Grosch, Gerd Geisslinger, Bernhard Brüne

International Journal of Cancer (Wiley) Germany, 28 May 2009


Key words: Cancer, angiogenesis, macrophages, sphingolipids, inflammation

Suppressor of Cytokine Signaling (SOCS)-1 Is Expressed in Human Prostate Cancer and Exerts Growth-Inhibitory Function through Down-Regulation of Cyclins and Cyclin-Dependent Kinases

Hannes Neuwirt, Martin Puhr, Frédéric R Santer, Martin Susani, Wolfgang Doppler, Gemma Marcias, Veronika Rauch, Maria Brugger, Alfred Hobisch, Lukas Kenner, Zoran Culig

The American Journal of Pathology (Elsevier) Austria, 01 May 2009


Key words: Prostate cancer, gastric carcinoma, neck cancer, melanoma, chronic myleoid leukemia

Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis

Franco Fortunato, Heinrich Bürgers, Frank Bergmann, Peter Rieger, Markus W Büchler, Guido Kroemer, Jens Werner

Gastroenterology (Elsevier) Germany, France, 09 April 2009


Organism: Rat

Tissue: Pancreas

Pathological State: Pancreatitis

Coexpression of the melatonin receptor 1 and nestin in human breast cancer specimens

O Rögelsperger, C Ekmekcioglu, W Jäger, M Klimpfinger, R Königsberg, D Krenbek, F Sellner, T Thalhammer

Journal of Pineal Research (Wiley) Austria, 30 March 2009


Key words: Breast cancer, MT1–nestin coexpression, immunofluorescence, quantification, TissueQuest

Organism: Human

Tissue: Breast

Pathological State: Cancer

Technical and Methodological Basics of Slide-Based Cytometry

Mittag A Bocsi J, Laffers W, Gerstner AOH

Cellular Diagnostics (Karger) Germany, 11 March 2009


Monocytes/macrophages in kidney allograft intimal arteritis: no association with markers of humoral rejection or with inferior outcome

Nicolas Kozakowski, Georg A Böhmig, Markus Exner, Afschin Soleiman, Nicole Huttary, Katalin Nagy-Bojarszky, Rupert C Ecker, Željko Kikic, Heinz Regele

Nephrology Dialysis Transplantation (Oxford University Press) Austria, 17 February 2009

Transplantation Medicine

Key words: Intimal arteritis, kidney allograft, lymphocyte, macrophage, monocyte

Organism: Human

Tissue: Blood Vessels

Pathological State: Allogeneic Transplantation

Human Rhinovirus Type 2 Uncoating at the Plasma Membrane Is Not Affected by a pH Gradient but Is Affected by the Membrane Potential

Ursula Berka, Abdul Khan, Dieter Blaas, Renate Fuchs

Journal of Virology (American Society for Microbiology) Austria, 04 February 2009


Organism: Human

Pathological State: Rhinovirus Infection

Cell Line: HeLa cells

Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions

Verónica-Haydée Lugo-Martínez, Constance S Petit, Stéphane Fouquet, Johanne Le Beyec, Jean Chambaz, Martine Pinçon-Raymond, Philippe Cardot, Sophie Thenet

Gastrointestinal and Liver Physiology (APS Journals) France, 01 February 2009


Key words: Intestinal epithelium

Organism: Mouse

Tissue: Small Intestine

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

Arthur Liesz, Elisabeth Suri-Payer, Claudia Veltkamp, Henrike Doerr, Clemens Sommer, Serge Rivest, Thomas Giese and Roland Veltkamp

Nature Medicine (Nature) Germany, Canada, 25 January 2009

Immunology, Neuroscience

Organism: Mouse

Cell Line: Regulatory T cells, Lymphocytes, Granulocytes, Microglia

The role of nanoparticle size in hemocompatibility

Andrea Mayer, Maria Vadon, Beate Rinner, Alexandra Novak, Reinhold Wintersteigerc, Eleonore Fröhlich

Toxicology (Elsevier) Austria, 22 January 2009


Key words: Nanotoxicology, Human blood, In vitro test system, Polystyrene particles, Particle siz, Surface charge, Nanoparticles

Organism: Human

Cell Line: Whole Blood

The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor

Andrea Ecker, Olivia Simma, Andrea Hoelbl, Lukas Kenner, Hartmut Beug, Richard Moriggl, Veronika Sexl

Frontiers in Bioscience (Frontiers Media S.A.) Austria, 01 January 2009


Organism: Mouse

Tissue: Lung, Salivary Gland, Liver, Kidney, Heart

Pathological State: Cancer

Expression of hemoglobin in rodent neurons

Dominik W Schelshorn, Armin Schneider, Wolfgang Kuschinsky, Daniela Weber, Carola Krüger, Tanjew Dittgen, Heinrich F Bürgers, Fatemeh Sabouri, Nikolaus Gassler, Alfred Bach, Martin H Maurer

Journal of Cerebral Blood Flow and Metabolism (SAGE Journals) Germany, 31 December 2008


Key words: erythropoietin, hemoglobin, hypoxia, mouse, neuron, rat

IL-17A Enhances Vitamin D3-Induced Expression of Cathelicidin Antimicrobial Peptide in Human Keratinocytes

Mark Peric, Sarah Koglin, Song-Min Kim, Shin Morizane, Robert Besch, Jörg C Prinz, Thomas Ruzicka, Richard L Gallo and Jürgen Schauber

The Journal of Immunology (American Association of Immunologists) USA, Germany, 15 December 2008


Key words: Immunofluorescence

Experimental COPD induced by solid combustible burn smoke in rats: a study of the emphysematous changes of the pulmonary parenchyma

ED Murărescu, F Eloae-Zugun, MS Mihailovici

Romanian Journal of Morphology and Embryology () Romania, 25 November 2008


Key words: emphysema, rat experimental model, COPD in non-smokers.

Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

Noria Harir, Cédric Boudot, Katrin Friedbichler, Karoline Sonneck, Rudin Kondo, Séverine Martin-Lannerée, Lukas Kenner, Marc Kerenyi, Saliha Yahiaoui, Valérie Gouilleux-Gruart, Jean Gondry, Laurence Bénit, Isabelle Dusanter-Fourt, Kaïss Lassoued, Peter Valent, Richard Moriggl, Fabrice Gouilleux

Blood (American Society of Hematology) France, 15 September 2008


Key words: Mast cells, Sense and antisense oligonucleotides,

d-Asb11 is an essential mediator of canonical Delta–Notch signalling

Sander H Diks, Maria A Sartori da Silva, Jan-Luuk Hillebrands, Robert J Bink, Henri H Versteeg, Carina van Rooijen, Anke Brouwers, Ajay B Chitnis, Maikel P Peppelenbosch and Danica Zivkovic

Nature Cell Biology (Nature) The Netherlands, USA, 07 September 2008

Cell Biology

Key words: Cell Biology, d-Asb11, Delta–Notch signalling

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

Kazuyoshi Takeda, Yuko Kojim, Kenichi Ikejim, Kenichi Harada, Shunhei Yamashina, Kyoko Okumur, Tomonori Aoyam, Steffen Fres, Hiroko Ieka, Nicole M Haynes, Erika Cretne, Hideo Yagita, Noriyoshi Sueyoshi, Nobuhiro Sato, Yasuni Nakanuma, Mark J Smyth, Ko Okumura

PNAS (PNAS) USA, 05 August 2008


Key words: Cholangitis primary, sclerosing cholangitis

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1

Robert Eferl, Peter Hasselblatt, Martina Rath, Helmut Popper, Rainer Zenz, Vukoslav Komnenovic, Maria-Helena Idarraga, Lukas Kenner, Erwin F Wagner

PNAS (PNAS) USA, 29 July 2008


Key words: Fra-2 transgenic mouse, idiopathic pulmonary, fibrosis, osteopontin, pulmonary arterial, hypertension fibrosis, mouse model

Apoptosis resistance in breast cancer stem cells through the regulation of Bcl2

Z Madjd, A Zare Mehrjerdi, A Sharifi, S Molanaei, S Zohoorian, M Asadi Lari

European Journal of Cancer (Elsevier) , 10 July 2008


Regulation of matrix metalloproteinases and tissue inhibitor of metalloproteinases by cobalt chloride-stimulated hypoxia in primary and metastatic breast cancer cells

WY Lee, F Ou-Yang, MF Hou, SF Yang, SC Huang

European Journal of Cancer (Elsevier) , 10 July 2008


Biodistribution and kinetics of the novel selective oncolytic adenovirus M1 after systemic administration

X Huang, L Zhuang, Y Cao, Q Gao, Z Han, D Tang, H Xing, J Zhou, D Ma

European Journal of Cancer (Elsevier) , 10 July 2008


Melatonin Receptor (MT1) and Nestin Coexpression: an indicator of more advanced breast cancer?

O Rögelsperger, C Ekmekcioglu, M Svoboda, R Königsberg, M Klimpfinger, W Jäger, T Thalhammer

European Journal of Cancer (Elsevier) Austria, 10 July 2008


Insulin-like growth factor binding protein-3 (IGFBP-3) in the prostate and in prostate cancer: Local production, distribution and secretion pattern indicate a role in stromal-epithelial interaction

Petra Massoner, Petra Haag, Christof Seifarth, Andreas Jurgeit, Hermann Rogatsch, Wolfgang Doppler, Georg Bartsch, Helmut Klocker

The Prostate (Wiley) Austria, 05 May 2008


Key words: IGFBP-3, prostate cancer, stromal-epithelial interaction, expression, secretion

A standards based ontological approach to information handling for use by organizations providing human tissue for research

Mary E Edgerton, Carl Morrison, Virginia A LiVolsi, Christopher A Moskaluk, Stephen J Qualman, M Kay Washington, William E Grizzle

Cancer Informatics (SAGE Journals) USA, 10 April 2008

Biological Methods

Acute anoxia stimulates proliferation in adult neural stem cells from the rat brain

Heinrich F Bürgers, Dominik W Schelshorn, Wolfgang Wagner, Wolfgang Kuschinsky, Martin H Maurer

Experimental Brain Research (Springer) Germany, 11 March 2008


Key words: Stem cell marker, arythroid progenitor, ogd group, neural stem cell

Lithium Promotes Adult Neural Progenitor Differentiation Via GSK3ß-Dependent Signaling Pathways

Heinrich F Bürgers, Dominik W Schelshorn, Wolfgang Kuschinsky and Martin H Maurer

The Open Enzyme Inhibition Journal () Germany, 02 January 2008

Cell Biology

Key words: Adult neural progenitor cell, Lithium, Two-dimensional gel electrophoresis, Rat.

Protein expression differs between neural progenitor cells from the adult rat brain subventricular zone and olfactory bulb

Martin H Maurer, Robert E Feldmann Jr, Heinrich F Bürgers, Wolfgang Kuschinsky

BMC Neuroscience (Springer) Germany, 01 January 2008


Key words: Neural progenitor cells, neuroblasts, GFAP-positive cells

Transplantation of adult neural progenitor cells transfected with vascular endothelial growth factor rescues grafted cells in the rat brain

Martin H Maurer, Christine Thomas, Heinrich F Bürgers, and Wolfgang Kuschinsky

International Journal of Biological Sciences (NCBI) Germany, 03 December 2007

Stem Cell Research

Key words: neural progenitor cell, neurosphere, transplantation, BrdU, Vascular Endothelial Growth Factor, VEGF.

Automated recognition of cell phenotypes in histology images based on membrane- and nuclei-targeting biomarkers

Bilge Karaçali, Alexandra P Vamvakidou, Aydin Tözeren

BMC Medical Imaging (Springer) USA, 07 September 2007

Medical Image Analysis

Key words: Histology, biomarkers

Chronische Inflammation als Promotor-und Behandlungstarget bei benigner Prostatahyperplasie (BPH) und beim Prostatakarzinom

G Kramer, D Mitteregger, A Maj-Hes, S Sevchenco, W Brozek

Der Urologe (Springer) Austria, 02 August 2007


Induction of Autophagy Does Not Affect Human Rhinovirus Type 2 Production

Marianne Brabec-Zaruba, Ursula Berka, Dieter Blaas, Renate Fuchs

Journal of Virology (American Society for Microbiology) Austria, 01 August 2007


Key words: Rhynovirus

Interactive Atlas of Histology: A Tool for Self-Directed Learning, Practice, and Self-Assessment

EZ Goubran, SP Vinjamury

Journal of Chiropractic Education () , 01 April 2007

Key words: atlases [publication type], chiropractic, education, histology, technology

Is Benign Prostatic Hyperplasia (BPH) an Immune Inflammatory Disease?

Gero Kramer, Dieter Mitteregger, Michael Marberger

European Urology (Elsevier) Austria, 11 December 2006


Key words: Autoimmunity, Benign prostatic hyperplasia, Chronic inflammation, Cytokines, Immune response, Infection

Pathological State: Prostatic Hyperplasia

Glycogen synthase kinase 3β (GSK3β) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone

MH Maurer, JO Brömme, RE Feldmann, A Järve, F Sabouri, HF Bürgers, DW Schelshorn, C Krüger, A Schneider, W Kuschinsky

Journal of Proteome Research (ACS Publications) Germany, 03 November 2006

Cell Biology

Key words: Neural stem cell • Neurosphere • Glycogen Synthase Kinase 3â • Two-dimensional gel electrophoresis • Rat • Subventricular zone

Microbubble-enhanced ultrasound to deliver an antisense oligodeoxynucleotide targeting the human androgen receptor into prostate tumours

Petra Haaga, Ferdinand Frauscherb, Johann Gradlb, Alexander Seitzb, Georg Schäferc, Jonathan R Lindnerd, Alexander L Klibanove, Georg Bartscha, Helmut Klockera, Iris E Eder

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, USA, 20 October 2006


Key words: Antisense oligonucleotides, Androgen receptor, Microbubbles, Ultrasound, Prostate cancer


K Tieman, L Stanbridge, H Rippon, N Maitland

European Urology (Elsevier) , 16 September 2006


Key words: Tumor, prostate


V Berge, H Ramberg, T Eide, A Svindland, KA Taskén

European Urology (Elsevier) , 16 September 2006



K Pfeil, C Seifarth, G Schäfer, G Steiner, R Rogojanu, G Gaillard, C Nowak, H Klocker

European Urology (Elsevier) , 16 September 2006



P Wikström, N Ohlson, A Bergh, P Stattin

European Urology (Elsevier) , 16 September 2006


Key words: Prostate cancer

3D parallel coordinate systems--a new data visualization method in the context of microscopy-based multicolor tissue cytometry

Streit M, Ecker RC, Osterreicher K, Steiner GE, Bischof H, Bangert C, Kopp T, Rogojanu R

Journal of the International Society for Advancement of Cytometry (Wiley) Austria, 05 May 2006


Key words: Polychromatic cells, automated microscopy-based multicolor tissue cytometry

An improved method for discrimination of cell populations in tissue sections using microscopy-based multicolor tissue cytometry

Ecker RC, Rogojanu R, Streit M, Oesterreicher K, Steiner GE

Journal of the International Society for Advancement of Cytometry (Wiley) Austria, 14 February 2006


Key words: Tissue citometry,

Fast Automatic Segmentation of Nuclei in Microscopy Images of Tissue Sections

Laurain V, Ramoser H, Nowak C, Steiner GE, Ecker R

Engineering in Medicine and Biology Society (IEEEXplore) Austria, 18 January 2006

Medical Image Analysis

Key words: Nuclei, microscopy images, segmentation

Leukocyte segmentation and classification in blood-smear images

Ramoser H, Adv Comput Vision GmbH, Wien, Laurain V, Bischof H, Ecker R

Engineering in Medicine and Biology Society (IEEEXplore) Austria, 18 January 2006


Systems biology and clinical cytomics: The 10th Leipziger workshop and the 3rd international workshop on slide-based cytometry

Attila Tárnok, Günther K Valet, Frank Emmrich

Cytometry Part A (Wiley) Germany, 20 December 2005


Key words: Predictive medicine, cytomics, biocomplexity, laser scanning cytometry, scanning fluorescence microscopy

Cell Proliferation Volume 38, Issue 4, pages 204–214, August 2005

Cell Proliferation (Wiley) Germany, 11 August 2005


Cell Proliferation Volume 38, Issue 4, pages 177–203, August 2005

Cell Proliferation (Wiley) Poland, 11 August 2005


Welcome to the 15th Annual Meeting of the German Society for Cytometry, DGfZ

Cell Proliferation (Wiley) Germany, 11 August 2005


Pimecrolimus leads to an apoptosis-induced depletion of T cells but not Langerhans cells in patients with atopic dermatitis

Wolfram Hoetzenecker, Rupert Ecker, Tamara Kopp, Anton Stuetz, Georg Stingl, Adelheid Elbe-Bürger

Journal of Allergy and Clinical Immunology (Elsevier) Austria, 06 April 2005

Allergy Research

Key words: Atopic dermatitis, Langerhans cells, T cells, apoptosis, corticosteroids, pimecrolimus

Cytomics goes 3D: toward tissomics

Ecker RC, Tarnok A

Cytometry Part A (Wiley) Austria, 24 March 2005


Regenerative and predictive medicine of cardiovascular disease: The 9th Leipziger workshop and the 2nd international workshop on slide based cytometry

Dominik Lenz, Markus J Barten, Sabine Hiller, Attila Tárnok, Ulrich Sack

Cytometry Part A (Wiley) Germany, 24 February 2005


Key words: Predictive medicine, regenerative medicine, stem cells, cytomics, laser scanning cytometry

Autocrine IL-0 partially prevents differentiation of neonatal dendritic epidermal leukocytes into Langerhans cells

Souyet Chang-Rodriguez, Rupert Ecker, Georg Stingl, Adelheid Elbe-Bürger

Journal of Leukocyte Biology (JLB) Austria, 04 June 2004


Key words: Antigen presentation/processing cytokines, cytokine receptors, dendritic cells skin

Microscopy-based multicolor tissue cytometry at the single-cell level

Rupert C Ecker, Georg E Steiner

Cytometry Part A (Wiley) Austria, 07 May 2004


Key words: Cytomics, tissue cytometry, multicolor staining, quantitative histology, pattern recognition

Application of spectral imaging microscopy in cytomics and fluorescence resonance energy transfer (FRET) analysis.

Ecker RC, de Martin R, Steiner GE, Schmid JA

Journal of the International Society for Advancement of Cytometry (Wiley) Austria, 07 May 2004


Decreased hippocampal mineralocorticoid:glucocorticoid receptor ratio is associated with low birth weight in female cynomolgus macaque neonates

Shirlene X Ong, Keefe Chng, Michael J Meaney, Jan P Buschdorf

Journal of Molecular Endocrinology (Society for Endocrinology) Austria, 06 April 2004

Reproductive Medicine

Key words: Glucocorticoid receptor cynomolgus macaque low birth weight MR:GR ratio

Inhibition of restenosis by tissue factor pathway inhibitor: in vivo and in vitro evidence for suppressed monocyte chemoattraction and reduced gelatinolytic activity

Christoph W Kopp, Thomas Hölzenbein, Sabine Steiner, Rodrig Marculescu, Helga Bergmeister, Daniela Seidinger, Isabella Mosberger, Christoph Kaun, Manfred Cejna, Reinhard Horvat, Johann Wojta, Gerald Maurer, Bernd R Binder, Johannes M Breuss, Rupert C Ecker, Rainer de Martin, and Erich Minar

Blood (American Society of Hematology) Austria, 10 March 2004


Key words: VSMC proliferation and migration, vascular restenosis

Using web-based animations to teach histology

Marc AS Brisbourne, Susan S-L Chin, Erica Melnyk, David A Begg

The Anatomical Record (Wiley) Austria, 28 February 2002


Key words: Animation, computer-assisted learning, CAL, histology, Internet, education, medical, mental modeling, microscopy

Detection of Epstein-Barr Virus in Hodgkin-Reed-Sternberg Cells: No Evidence for the Persistence of Integrated Viral Fragments in Latent Membrane Protein- (LMP-)-Negative Classical Hodgkin's Disease

Andrea Staratschek-Jox, Sascha Kotkowski, Gazanfer Belge, Thomas Rüdiger, Jörn Bullerdiek, Volker Diehl, Jürgen Wolf

The American Journal of Pathology (Elsevier) Germany, 10 October 2000


Key words: Hodgkin's disease, EBV genome, in situ hybridization

Automated data acquisition by confocal laser scanning microscopy and image analysis of triple stained immunofluorescent leukocytes in tissue

Georg Erich Steiner, Rupert Christian Ecker, Gero Kramer, Felix Stockenhuber, Michael Johann Marberger

Journal of Immunological Methods (Elsevier) Austria, 07 March 2000

Medical Image Analysis


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