Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 1 - 10 of 3293
01
Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer's disease

ZJ Yan, M Ye, J Li, DF Zhang, YG Yao

Molecular Neurodegeneration (BMC) China , 31 May 2025

Neuroscience

Key words: Alzheimer’s disease, Choroid plexus, Single-cell transcriptome, Lipid accumulation, Neuroinflammation

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimers

02
PMN recruitment in inflammatory lung injury models follows classical transendothelial migration paradigms requiring PECAM-1 and CD99

ME Haynes, E Arias, DP Sullivan, WA Muller

Lung Cellular and Molecular Physiology (american physiological society) USA , 30 May 2025

Pulmonology

Key words: Inflammatory cascade; polymorphonuclear cells; pulmonary inflammation; transmigration; PECAM-1; CD99

Organism: Mouse

Tissue: Lung

Pathological State: Lung Injury

03
Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer

D Zhou, E Tang, W Wang, Y Xiao, J Huang, J Liu, C Zheng, K Zhang, R Hu, F Wang, P Xiong, X Chu, W Li, D Liu, X Zeng, D Zheng, L Wang, Y Zheng, S Zhang

Cell Reports Medicine (Cell) China , 30 May 2025

Oncology

Key words: advanced colorectal cancer, DR5, CDK4, antibody-drug conjugate, Oba01, abemaciclib, synergetic effect

Organism: Human

Tissue: Colon

Pathological State: Cancer

04
Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights

SSF Yuan, A Vadhan, HDH Nguyen, PY Chen, CH Tseng, CH Wu, YC Chen, YC Wu, SC Hu, S Lo, MF Hou, YY Wang

Cancer & Metabolism (Springer) Taiwan , 29 May 2025

Oncology

Key words: Cancer Metabolism, Breast Cancer, Cancer Biology, Cancers, Energy Metabolism, Oncology

Organism: Human

Tissue: Breast

Pathological State: Cancer

05
High-altitude hypoxia exacerbates chemotherapy-induced myelosuppression by lowering serum G-CSF/GM-CSF and regulating apoptosis and proliferation

J Shi, F Zhao, T Qiu, D Ren, Z Li, J Ma, J Zhao

Discover Oncology (Springer) China , 28 May 2025

Oncology, Pharmacology

Key words: High-altitude hypoxia, Chemotherapy, Myelosuppression, Hematopoietic function

Organism: Mouse

Tissue: Bone

Pathological State: Hypoxia

06
Notable influences of estrogen and sex-specific microenvironment in colorectal cancer revealed by single-cell transcriptome analysis

Y Zheng, C Yang, G Xiao, M Lei, P Qin, H Chen, H Lin

International Journal of Medical Sciences (Ivyspring) China , 28 May 2025

Oncology

Key words: Colorectal cancer, Sex, Estrogen, Single-cell RNA sequencing, Tumor microenvironment

Organism: Human

Tissue: Colon

Pathological State: Cancer

07
Cleavage of the Meckel-Gruber syndrome protein TMEM67 by ADAMTS9 uncouples Wnt signaling and ciliogenesis

M Ahmed, S Fischer, KL Robert, KI Lange, MW Stuck, S Best, CA Johnson, GJ Pazour, OE Blacque, S Nandadasa

Nature Communications (Nature) USA, UK, Ireland , 28 May 2025

Cell Biology

Key words: Ciliogenesis, Mechanisms of disease, Polycystic kidney disease

Organism: Mouse

Tissue: Kidney, Heart

Pathological State: Meckel-Gruber syndrome

08
Targeting CDH11 with Celecoxib and Derivatives to Suppress Esophageal Squamous Cell Carcinoma Proliferation and Invasion

L Xiao, B Yang, Y Zhou, J Zhang, X Zhang, W Yang, M Sun, M Li, X Zhao, F Tian

Pathology -Research and Practice (Elsevier) China , 27 May 2025

Oncology

Key words: Esophageal squamous cell carcinoma, Cadherin-11, Celecoxib, 2, 5-DiMethyl Celecoxib

Organism: Human

Pathological State: Cancer

Cell Line: KYSE150

09
Synergistic reproductive toxicity of microcystin-LR and polystyrene micro/nano-plastics in male zebrafish

J Duan, Y Xiao, W Wang, Y Yuan, W Ju, B Wu, L Hu, X Tuo, M Jiang, S Zhao

Ecotoxicology and Environmental Safety (Elsevier) China , 26 May 2025

Reproductive Medicine

Key words: Microcystin-LR, PSMPs/PSNPs, Oxidative stress, DNA damage, Mitochondrial damage

Organism: Fish

Tissue: Testis

Pathological State: Chemical Exposure

10
BACE1 Inhibition Protects Against Type 2 Diabetes Mellitus by Restoring Insulin Receptor in Mice

T Lin, T Liang, Y Shen, F Gao

International Journal of Molecular Sciences (MDPI) China , 26 May 2025

Endocrinology

Key words: β-secretase 1 (BACE1); insulin receptor (InsR); insulin resistance; type 2 diabetes mellitus (T2DM); cognitive impairment

Organism: Mouse

Tissue: Liver

Pathological State: Diabetes

Results 1 - 10 of 3293
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