Identification of hypoxic macrophages in glioblastoma with therapeutic potential

Wang et al. used spatial transcriptomics to characterize subsets of tumor-associated macrophages (TAMs) known as monocyte-derived TAMs. They identified a cluster of hypoxia-TAM oversecreting adrenomedullin with multiplex immunostaining imaged with TissueFAXS Spectra, and StrataQuest for marker identification.