The evolving understanding of cancer biology underscores the pivotal role of epigenetic modifications - heritable yet reversible changes in gene expression that do not alter the DNA sequence.

A research group in China analyzed CD39+CD8+ T cells in esophageal squamous cell carcinoma. Based on mIF-stained samples acquired on the TissueFAXS platform, they propose these cells as new markers for diagnosis and prognosis.

Researchers demonstrate TCL1A+ B cells drive TLS formation in OSCC and serve as a positive prognostic factor using mIF and TissueFAXS imaging.

This webinar explores how tissue cytometry enables investigation of fatty liver disease, providing insights into liver pathology and immune interactions.

This study highlights how contextual imaging with multiplexed immunofluorescence and automated analysis quantifies cell density and spatial distributions in ESCC. Results reveal MRPL13’s link to CD8+ T-cell infiltration in the tumor microenvironment.

Researchers from Soochow University investigated the B7-H4/USP2a axis in lung cancer using TissueFAXS Spectra for TMA imaging and StrataQuest for protein expression analysis.

Researchers investigated HHLA2 as a prognostic marker in LSCC using multiplexed IHC on TMA cores. TissueFAXS automated imaging and StrataQuest analysis revealed HHLA2 expression across immune cell populations.

Tissue microarrays (TMAs) enable high-throughput analysis of hundreds of samples on a single slide. Combined with automated scanning and StrataQuest image analysis, TMAs streamline diagnostics, biomarker discovery, and tissue classification in research and clinics.

High-throughput tissue cytometry enables researchers to explore complex tissue microenvironments and discover novel biomarkers. With systems like TissueFAXS SL and StrataQuest analysis, large-scale scanning and advanced spatial analysis become efficient and precise.

A new study shows that combining type I interferon (MxA) expression with CD8+ T cell density can predict patient response to neoadjuvant treatment in rectal adenocarcinoma. TissueFAXS CHROMA and StrataQuest enabled precise multispectral imaging and analysis.

Pencik et al. identified STAT3 as a potential target for treating lethal metastatic prostate cancer. Tissue cytometry solutions were used to assess STAT3 and pathway markers in situ.

Dr. Rupert Ecker co-authored a review on genomic and phenotypic biomarkers guiding precision medicine in advanced prostate cancer, highlighting strategies for diagnosis, prognosis, and treatment prediction.

A recent study using TissueFAXS and HistoQuest revealed that xCT inhibition by erastin may trigger ferroptosis in HNSCC cells. Erk1/2 activation sensitized tumor cells to this process, suggesting novel therapeutic strategies for head and neck cancer.

Zhou et al. applied AI-assisted analysis to pancreatic adenocarcinoma, quantifying CD8+ TILs, cancer stem cells, and tumor budding. StrataQuest revealed immune and tumor features predictive of patient survival.

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis and its effect on CpG methylation of protease serine 3 isoforms in lung cancer. Using 7-marker multiplex staining with TissueFAXS SPECTRA and StrataQuest, they differentiated isoforms showing paradoxical effects.

Savic et al. studied the role of Erk 1/2 kinases in ferroptosis induction in HNSCC. They found erastin to be a potent ferroptosis inducer, strongly dependent on Erk 1/2 activity. IHC-stained samples were quantified using TissueFAXS and HistoQuest.

Yan et al. identified COL8A1 as a potential biomarker of poor chemotherapy response and survival in PDAC. TissueFAXS and StrataQuest enabled imaging and segmentation of tumor structures.

Wang et al. investigated RNA and protein expression of immune checkpoint molecules in glioma, highlighting prognostic value. TissueFAXS SPECTRA enabled multispectral TMA scanning, and StrataQuest was used for in-depth phenotyping.