The evolving understanding of cancer biology underscores the pivotal role of epigenetic modifications - heritable yet reversible changes in gene expression that do not alter the DNA sequence.

Dr. Lukas Kenner presents his research on STAT3’s dual role in prostate cancer. TissueFAXS, HistoQuest, and StrataQuest enabled whole-slide imaging and single-cell quantification.

Dr. Amirreza Mahbod presents how deep learning enhances nuclei segmentation and tackles challenges in histological image analysis.

Image-based cytometry is transforming tissue analysis by combining microscopy with flow cytometry features. It enables rapid, automated characterization of cells in their native environment, advancing pathology, oncology, and precision medicine with AI integration.

A recent study using TissueFAXS and HistoQuest revealed that xCT inhibition by erastin may trigger ferroptosis in HNSCC cells. Erk1/2 activation sensitized tumor cells to this process, suggesting novel therapeutic strategies for head and neck cancer.

Spatial tissue cytometry preserves cells in their native environment, enabling single-cell analysis and spatial insights into tissue organization. Discover how TG’s imaging and analysis platforms unlock powerful applications in research and precision medicine.

Prof. Nicolas C. Hoch, University of Sao Paulo, is presenting his research on signaling and repair of DNA damage. He and his group are utilizing the power of TissueFAXS i PLUS slide scanning and the high-end image analysis solution, StrataQuest, for their research.

StrataQuest enables high-content image analysis of IMC datasets. This case study demonstrates single-cell and proximity measurements across 30 markers within one tissue section for comprehensive phenotyping.

This white paper details the first in-depth tissue cytometry analysis of CD3+ T-cell subsets in COVID-19 lungs. Using TissueFAXS PLUS and StrataQuest, researchers uncovered dysfunctional CD8+ T cells and expansion of cytotoxic CD4+ T cells driving impaired immunity.

Dr. Thomas Diefenbach and colleagues at the Ragon Institute analyzed B and T cell populations in COVID-19 patient lymph nodes using TissueFAXS and StrataQuest. Their microscopy and image analysis revealed disrupted germinal centers and impaired humoral immunity.

Claire Vinel, PhD (Queen Mary University London), presents her Nature Communications study on epigenetic mechanisms in glioblastoma. The work highlights Treg recruitment via glycosaminoglycans and identifies druggable, patient-specific targets using integrated transcriptome and methylome analysis.

A study in The Journal of Clinical Investigation (Mvaja et al.) shows the limited potential of duodenal CD8+ T cells in people living with HIV. High-content immunophenotyping was performed using TissueFAXS i PLUS and TissueQuest single-cell analysis.

Multispectral cytometry resolves spectral overlap to enable accurate, high-parameter analysis of cells and tissues. Learn how this technology, paired with spectral unmixing and advanced imaging, expands applications from cancer research to immunotherapy.

Collins et al. (Ragon Institute, Harvard/MIT/MGH) reveal key virologic and immunologic factors of durable HIV control. HIV+ lymph nodes were visualized via RNAScope and acquired using TissueFAXS Q (Cell Press).

Researchers at University of Regensburg identified a tissue-resident Treg subpopulation linked to wound healing. StrataQuest image analysis quantified epidermal repair processes in the stratum corneum.