09. November 2021

What is Quantitative Histopathology?

Histopathology is the scientific branch focusing on assessment of diseases by examining stained biological tissue sections, particularly in human subjects. This field can give immense insight into biological and medical areas of study. With advancing technology and innovative capabilities, laboratories can gain more insights in the pathobiology of diseases every day.
One major target for researchers dealing with histopathological data is the quantitation of morphology and specific markers within cells and tissue samples. This blog post will review what quantitative histopathology is, its wider applications, and why products to conduct quantitative histopathology procedures effectively are necessary.

Defining Quantitative Histopathology
Quantitative histopathology is the area of histopathology concerned with measuring quantities or amounts specific markers of tissue and cell specimens. This field requires extremely meticulous and high performing processes to accurately quantify the complex microscopic building blocks that make up biological tissue.
Quantitative histopathology is often performed using tissue cytometers and requires high functioning imaging capabilities to visualize and analytical capabilities to analyse various tissue related parameters properly. Quantitative histopathology can provide information on tissue and cellular structures as well as changes due to diseases, making it invaluable to the scientific research, medical and health communities.

Applications of Quantitative Histopathology
Due to quantitative histopathology revealing valuable insight into tissue and cellular structure and function, it is of use to a wide range of health and medical applications. For example, quantitative histopathology’s visualization and quantitation techniques are relevant to cancer diagnosis or even personalized medical treatments.
Histopathologists commonly perform biopsies and examine tissue samples and changes to cells due to disease or illness. With these results, doctors may diagnose a disease in a patient and use the information to then develop a specialized therapy plan based on the individual cellular changes in the patient’s body tissues.
Furthermore, quantitative histopathology is very valuable in the biomedical research realm. For instance, this technique was used in the study of Miller et al. to analyze tissues of colorectal cancer patients to assess the prognostic and predictive value of cell densities with the cancer-related transcription factor SOX2. This research contributed knowledge to the cancer and stem cell research fields as well as the chemotherapy industry. Therefore, it is evident that high performing, efficient, and accurate technological methods are necessary to meet the imaging and analytical needs of quantitative histopathology.

Quantitative Histopathology with TissueGnostics
Tissue Gnostics offers the TissueFAXS series of tissue cytometers optimized to meet a wide variety of tissue analysis needs. For example, the TissueFAXS Q and SL Q Systems engage in high performance confocal imaging and TissueFAXS SPECTRA and TissueFAXS CHROMA provide multispectral imaging with advanced software technology.
TissueFAXS is compatible with TissueGnostics StrataQuest, an image processing solution capable of advanced digital contextual image analysis. As a leading expert in tissue cytometry, TissueGnostics offers clients full control over the quantitation process with the many advantages of the aforementioned products described in more detail on our website.
TissueGnostics is a pioneer in tissue cytometry, offering the ability to engage in the many possibilities of quantitative histopathology. If you are interested in learning more about quantitative histopathology solutions, please do not hesitate to contact a member of the TissueGnostics team today.



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