Breast cancer continues to affect millions of people around the world—and for most, the diagnosis involves a hormone receptor-positive subtype.

TissueGnostics proudly participated in the recent mid-term meeting and first doctoral school of the Horizon Europe Marie Skłodowska-Curie Doctoral Network (DN) project eRaDicate.

TG joins SMART CRC as an industrial partner. This $238M initiative accelerates curative therapies for cancer, heart disease, Alzheimer’s, arthritis, and age-related conditions.

The evolving understanding of cancer biology underscores the pivotal role of epigenetic modifications - heritable yet reversible changes in gene expression that do not alter the DNA sequence.

Dr. Diana Mechtcheriakova, Medical University of Vienna, presents research on lymphoid structures in systemic immunity and anti-cancer responses, with applications in colorectal cancer.

A new study shows PD-1+ Treg/CTL ratio combined with TLS predicts prognosis and treatment response in gastric cancer using mIF, TissueFAXS, and StrataQuest.

A research group in China analyzed CD39+CD8+ T cells in esophageal squamous cell carcinoma. Based on mIF-stained samples acquired on the TissueFAXS platform, they propose these cells as new markers for diagnosis and prognosis.

Researchers demonstrate TCL1A+ B cells drive TLS formation in OSCC and serve as a positive prognostic factor using mIF and TissueFAXS imaging.

Frontiers in Medicine launches a call for papers on cancer organoid co-culture models, with Prof. Uwe Ritter, Dr. Talita Glaser and Dr. Rupert Ecker (CEO, TissueGnostics) as topic editors. Deadline: 03.09.2025.

Researchers from Soochow University investigated the B7-H4/USP2a axis in lung cancer using TissueFAXS Spectra for TMA imaging and StrataQuest for protein expression analysis.

Researchers combined spatial transcriptomics and multiplexed staining with TissueFAXS Spectra to identify a new CAF subset linked to stemness. StrataQuest enabled single-cell detection and tissue classification.

In HNSCC, CD8+ T-cell infiltration is often impaired. Chuwen Li et al. used mIF, TissueFAXS Spectra, and StrataQuest to image and analyze the spatial distribution of Gal9+ CAFs and CD8+ T cells, complementing prior spatial transcriptomics.

The newest StrataQuest supports in-depth neighborhood analysis with exportable data for statistics. It includes manifold learning (t-SNE, UMAP, SONG), violin plots, 3D diagrams, and other tools that give full control of data.

Dr. Qu Jiang (Leipzig) presents new findings on the oncogenic role of KDM1A in CLL. Using StrataQuest, her team quantified IF-stained murine spleen sections to assess leukemic burden after Kdm1a knockdown.

Researchers investigated HHLA2 as a prognostic marker in LSCC using multiplexed IHC on TMA cores. TissueFAXS automated imaging and StrataQuest analysis revealed HHLA2 expression across immune cell populations.

Wang et al. used spatial transcriptomics to characterize subsets of tumor-associated macrophages (TAMs) known as monocyte-derived TAMs. They identified a cluster of hypoxia-TAM oversecreting adrenomedullin, confirmed by multiplex immunostaining with TissueFAXS Spectra imaging platform, and StrataQuest image analysis software was employed for marker identification.

Dr. Lukas Kenner, Medical University of Vienna, discusses the impact of micro- and nanoplastic particles on human health, in particular potential effect on cancer development.

The eRaDicate project was launched to test novel nuclear-receptor targeting drugs as anti-cancer agents, such as the retinoic acid receptor (RAR) and the vitamin D receptor (VDR) using a variety of molecular biology methods. TissueGnostics is the official industry beneficiary of the project.