Activated Erk 1/2 Kinases Decrease Cell Viability Caused by Erastin

Savic et al. studied the role of Erk 1/2 kinases in ferroptosis induction in HNSCC. They found erastin to be a potent ferroptosis inducer, strongly dependent on Erk 1/2 activity. IHC-stained samples were quantified using TissueFAXS and HistoQuest.