Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 971 - 980 of 3421
971
Laser ablation-inductively coupled plasma-mass spectrometry analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma

A Tisza, T Klikovits, M Benej, S Torok, B Szeitz, Z Valko, MA Hoda, B Hegedus, M Bonta, W Nischkauer, K Hoetzenecker, A Limbeck, K Schelch, V Laszlo, Z Megyesfalvi, B Dome

British Journal of Clinical Pharmacology (Wiley) Hungary, Austria, Germany, Sweden , 05 June 2023

Oncology, Pharmacology

Key words: intratumoural drug distribution, laser ablation-inductively coupled plasma-mass spectrometry,mass spectrometry imaging, neoadjuvant chemotherapy, platinum, pleural mesothelioma

Organism: Human

Pathological State: Cancer

972
Fluoxetine inactivates STAT3/NF-κB signaling and promotes sensitivity to cisplatin in bladder cancer

CJ Yang, ZL Tan, JD Yang, FT Hsu, CH Chiang

Biomedicine & Pharmacotherapy (Elsevier) Taiwan , 03 June 2023

Oncology

Key words: Muscles invasive bladder cancer, Fluoxetine, STAT3, NF-κB, Apoptosis

Organism: Mouse

Tissue: Bladder, Allograft Tumor

Pathological State: Cancer

973
Axonal mapping of the motor cranial nerves

V Tereshenko, U Maierhofer, DC Dotzauer, G Laengle, O Politikou, G Carrero Rojas, C Festin, M Luft, FJ Jaklin, LA Hruby, A Gohritz, D Farina, R Blumer, KD Bergmeister, OC Aszmann

Frontiers in Neuroanatomy (Frontiers Media S.A.) Austria, USA, Switzerland, UK , 02 June 2023

Neuroscience

Key words: facial nerve, hypoglossal nerve, masseteric nerve, facial muscles, sensory feedback, sympathetic axons, motor control, proprioception

Organism: Human

Tissue: Nerve

974
Lineage-specific accelerated sequences underlying primate evolution

X Bi, L Zhou, JJ Zhang, S Feng, M Hu, DN Cooper, J Lin, J Li, DD Wu, G Zhang

Science Advances (Science) China, UK , 01 June 2023

Evolution

Organism: Human

Tissue: Brain

975
E7050 Suppresses the Growth of Multidrug-Resistant Human Uterine Sarcoma by Inhibiting Angiogenesis via Targeting of VEGFR2-Mediated Signaling Pathways

TT Huang, CM Chen, SS Lin, YW Lan, HC Cheng, KB Choo, CC Wang, TH Huang, KY Chong

International Journal of Molecular Sciences (MDPI) Taiwan, USA, Malaysia , 31 May 2023

Oncology

Key words: E7050, VEGFR2, VEGF, multidrug-resistant human uterine sarcoma, angiogenesis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

976
Gastroprotective effects of Machilus zuihoensis Hayata against acidic ethanol-induced gastric ulcer in mice

SC Huang, WJ Wu, YJ Lee, MS Tsai, XZ Yan, HC Lin, PY Lai, KT Wang, JW Liao, JC Tsai

Journal of Traditional and Complementary Medicine (Elsevier) Taiwan , 31 May 2023

Gastroenterology

Key words: Gastroprotection, Mucus secretion, Antioxidation, Anti-inflammation, MAPK and NF-κB signaling pathways

Organism: Mouse

Tissue: Stomach, Kidney, Liver

Pathological State: Gastric ulcer

977
NQO1/CPT1A promotes the progression of pancreatic adenocarcinoma via fatty acid oxidation: NQO1/CPT1A promotes PAAD via FAO

R Xu, Y Liu, L Ma, Y Sun, H Liu, Y Yang, T Jin, D Yang

Acta Biochimica et Biophysica Sinica (Oxford University Press) China , 29 May 2023

Oncology, Endocrinology

Key words: NQO1, PAAD, metastasis, fatty acid oxidation, CPT1A

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

978
Inhibition of CDK9 exhibits anticancer activity in hepatocellular carcinoma cells via targeting ribonucleotide reductase

JC Lin, TP Liu, YB Chen, TS Huang, TY Chen, PM Yang

Toxicology and Applied Pharmacology (Elsevier) Taiwan , 27 May 2023

Oncology, Pharmacology

Key words: Cyclin-dependent kinase 9, Hepatocellular carcinoma, Protein degradation, Ribonucleotide reductase

Organism: Human

Tissue: Liver

Pathological State: Cancer

979
Emodin, a Natural Anthraquinone, Increases Uric Acid Excretion in Rats with Potassium Oxonate-Induced Hyperuricemia

SW Hou, SJ Chen, JD Shen, HY Chen, SJ Wang, CH Wang, KM Man, PL Liu, MY Tsai, YH Chen, WC Chen

Pharmaceuticals (MDPI) Taiwan , 25 May 2023

Toxicology

Key words: uric acid, gout, emodin, potassium oxonate, traditional Chinese medicine, rats

Organism: Rat

Tissue: Kidney

980
Characterization of genetic humanized mice with transgenic HLA DP401 or DRA but deficient in endogenous murine MHC class II genes upon Staphylococcus aureus pneumonia

F Li, B Niu, L Liu, M Zhu, H Yang, B Qin, X Peng, L Chen, C Xu, X Zhou

Animal Models and Experimental Medicine (Wiley) China , 23 May 2023

Pathology

Organism: Mouse

Tissue: Lung, Lymphoid Tissue

Pathological State: Bacterial Infection

Results 971 - 980 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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