Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 941 - 950 of 3476
941
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

X Zheng, C Huang, Y Lin, B Han, Y Chen, C Li, J Li, Y Ding, X Song, W Wang, W Liang, J Wu, J Wu, J Gao, C Wei, X Zhang, T Zhuchi, Y Sen

Signal Transduction and Targeted Therapy (Nature) China , 04 September 2023

Genetics

Key words: Experimental models of disease, Genetic engineering

Organism: Monkey

Tissue: Breast

Pathological State: Cancer

942
Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4+ T cells through regulating type 2 conventional dendritic cells

J Luo, S Pang, Z Hui, H Zhao, S Xu, W Yu, L Yang, Q Sun, X Hao, F Wie, J Wang, X Ren

Theranostics (Ivyspring) China , 04 September 2023

Oncology, Pharmacology

Key words: STING, ADU-S100, Tim-3, DC, Cancer immunotherapy

Organism: Human

Tissue: Lung

Pathological State: Cancer

943
Anti-tumor effects of deubiquitinating enzyme inhibitor PR-619 in human chondrosarcoma through reduced cell proliferation and endoplasmic reticulum stress-related apoptosis

WC Lin, YL Chiu, KL Kuo, PM Chow, CH Hsu, SM Liao, JR Dong, SC Chang, SW Liu, TJ Liu, FS Hsu, KC Wang, YC Lin, CC Chang, KY Huang

American Journal of Cancer Research (e-Century Publishing) Taiwan , 03 September 2023

Oncology

Key words: Deubiquitinating enzyme, chondrosarcoma, apoptosis, endoplasmic reticulum stress

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

944
Plasmon-activated water as a therapeutic strategy in Alzheimer's disease by altering gut microbiota

CH Cheng, YC Liu, YCSH Yang, KJ Lin, D Wu, YR Liu, CC Chang, CT Hong, CJ Hu

Aging (Impact Journals) Taiwan , 02 September 2023

Neuroscience, Gastroenterology

Key words: Alzheimer’s disease, plasmon-activated water, fecal microbiota transplantation, microbiota, beta amyloid, tau

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s disease

945
Impact of apolipoprotein A1 on tumor immune microenvironment, clinical prognosis and genomic landscape in hepatocellular carcinoma

Y Wang, S Chen, X Xiao, F Yang, J Wang, H Zong, Y Gao, C Huang, X Xu, M Fang, X Zhang, C Gao

Precision Clinical Medicine (Oxford Academic) China, The Netherlands , 02 September 2023

Oncology

Organism: Human

Tissue: Liver

Pathological State: Cancer

946
Mesenchymal stem cells promote polarization of M2 macrophages in mice with acute-on-chronic liver failure via Mertk/JAK1/STAT6 signaling

Z Li, J Chen, J Zhang, Z Lei, L Wu, S Meng, J Wang, J Xiong, DN Lin, Jz Wang, ZL Gao, BL Lin

Stem Cells (Oxford Academic) China , 02 September 2023

Stem Cell Research, Hepathology

Key words: mesenchymal stem cell, acute-on-chronic liver failure, macrophage, polarization, Mertk, JAK1/STAT6

Organism: Mouse

Tissue: Liver

Pathological State: Liver failure

947
Escherichia coli adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4

W Zhang, L Xu, X Zhang, J Xu, JO Jin

Frontiers in Immunology (Frontiers Media S.A.) China, South Korea , 01 September 2023

Immunology

Key words: fimH, macrophage polarization, toll-like receptor 4, myeloid differentiation factor 2, tumor-associated macrophage

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

948
Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma

L Pang, M Dunterman, S Guo, F Khan, Y Liu, E Taefi, A Bahrami, C Geula, WH Hsu, C Horbinski, CD James, P Chen

Nature Immunology (Nature) USA , 31 August 2023

Oncology, Immunology

Key words: Cancer immunotherapy, Immunosurveillance, Stem cells, Tumour immunology

Cell Line: HMC3 microglia, 293T cells, CT2A cells, SIM-A9 microglia, and SB28 and GL261 cells

949
The Cooperative Human Tissue Network of the National Cancer Institute: Supporting cancer research for 35 years

SJ McCall, IA Lubensky, CA Moskaluk, A Parwani, K Radin, NC Ramirez, Z Von Menchhofen, MK Washington, VA LiVolsi

Molecular Cancer Therapeutics (AACR) USA , 30 August 2023

Oncology

950
Engineering tumoral vascular leakiness with gold nanoparticles

MI Setyawati, Q Wang, N Ni, JK Tee, K Ariga, PC Ke, HK Ho, Y Wang, DT Leong

Nature Communications (Nature) Singapore, China, Japan, Australia , 30 August 2023

Oncology, Nanomedicine

Key words: Cancer, Nanoscale materials

Organism: Mouse

Tissue: Xenograft Tumor, Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

Results 941 - 950 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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