Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 901 - 910 of 3421
901
Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

X Ma, Q Wang, C Sun, I Agarwal, H Wu, J Chen, C Zhao, G Qi, Q Teng, C Yuan, S Yan, J Peng, R Li, K Song, Q Zhang, B Kong

Cell Reports (Cell Press) China , 29 August 2023

Oncology, Immunology

Key words: IFN-β signaling, T cell exhaustion, TCF19, endometrial cancer, immune checkpoint blockade therapy, microsatellite instable

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

902
Single-cell transcriptomics reveals granzyme K-expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD

R Aoyagi, T Maehara, R Koga, R Munemura, T Tomonaga, Y Murakami, A Doi, H Yamamoto, T Kiyoshima, S Kawano, S Nakamura

Journal of Allergy and Clinical Immunology (Elsevier) Japan , 29 August 2023

Immunology

Key words: Single-cell RNA sequencing, IgG4-related disease, germinal center, granzyme K, T follicular helper cells, T follicular regulatory cells

Organism: Human

Tissue: Salivary Gland, Lymphoid Tissue, Kidney

Pathological State: IgG4-related disease

903
The rs1421085 variant within FTO promotes brown fat thermogenesis

Z Zhang, N Chen, N Yin, R Liu, Y He, D Li, M Tong, A Gao, P Lu, Y Zhao, H Li, J Zhang, D Zhang, W Gu, J Hong, W Wang, L Qi, G Ning, J Wang

Nature Metabolism (Nature) China, USA , 29 August 2023

Endocrinology

Key words: Fat metabolism, Genome-wide association studies, Mechanisms of disease

Organism: Human

Tissue: Adipose Tissue

904
Mitochondrial integrated stress response controls lung epithelial cell fate

SH Han, M Lee, Y Shin, R Giovanni, RP Chakrabarty, MM Herrerias, LA Dada, AS Flozak, PA Reyfman, B Khuder, CR Reczek, L Gao, J Lopéz-Barneo, CJ Gottardi, GR Scott Budinger, NS Chandel

Nature (Nature) USA, South Korea, Spain , 28 August 2023

Pulmonology

Key words: Differentiation, Metabolomics

Organism: Mouse

Tissue: Lung

905
Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4+ T cells through regulating type 2 conventional dendritic cells

J Luo, S Pang, Z Hui, H Zhao, S Xu, W Yu, L Yang, Q Sun, X Hao, F Wei, J Wang, X Ren

Theranostics (Ivyspring International Publisher) China , 25 August 2023

Oncology, Immunology

Key words: STING, ADU-S100, Tim-3, DC, Cancer immunotherapy

Organism: Human

Tissue: Lung

Pathological State: Cancer

906
Anti-angiogenic therapy using the multi-tyrosine kinase inhibitor Regorafenib enhances tumor progression in a transgenic mouse model of ß-cell carcinogenesis

MJ Egidi, S Krug, J Haybaeck, P Michl, H Griesmann

British Journal of Cancer (Nature) Germany, Austria , 24 August 2023

Oncology

Key words: Pancreatic cancer, Target validation, Tumour angiogenesis

Organism: Mouse

Tissue: Placenta

Pathological State: Cancer

907
Clinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence

Y Zhang, Y Bai, XX Ma, JK Song, Y Luo, XY Fei, Y Ru, Y Luo, JS Jiang, Z Zhang, D Yang, TT Xue, HP Zhang, TY Liu, YW Xiang, L Kuai, YQ Liu, B Li

Cell Death & Disease (Nature) China , 24 August 2023

Oncology

Key words: Melanoma, Prognostic markers

Organism: Human

Tissue: Skin

Pathological State: Cancer

908
PNU-74654 Induces Cell Cycle Arrest and Inhibits EMT Progression in Pancreatic Cancer

TL Chien, YC Wu, HL Lee, WW Sung, CY Yu, YC Chang, CC Lin, CC Wang, MC Tsai

Medicina (MDPI) Taiwan , 24 August 2023

Oncology, Pharmacology

Key words: pancreatic adenocarcinoma, β-catenin, WNT, cell cycle arrest, migration

Cell Line: BxPC-3 and MiaPaCa-2 cell lines

909
Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress

ZY Yang, XC Yan, L Liang, CC Gao, PR Zhang, Y Liu, JX Sun, B Ruan, JL Duan, RN Wang, XX Feng, B Che T Xiao, H Han

The Journal of Clinical Investigation (Am Soc Clin Investig) China , 22 August 2023

Oncology

Key words: SPEN, rDNA, nucleolar stress, pRNA, endothelial cells, tumor vessels

Organism: Mouse

Tissue: Eye

Pathological State: Cancer

910
Chemotherapy-induced nanovaccines implement immunogenicity equivalence for improving cancer chemoimmunotherapy

R Li, Y Hao, K Roche, G Chen, W Pan, AZ Wang, Y Min

Biomaterials (Elsevier) China, USA , 21 August 2023

Oncology, Pharmacology

Key words: Chemoimmunotherapy, Nanovaccines, Neoantigens, Damage associated molecular patterns, Anti-PD-1

Organism: Mouse

Tissue: Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

Results 901 - 910 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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