Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 881 - 890 of 3476
881
Light damage induces inflammatory factors in mouse retina and vitreous humor

W Liu, X Zhu, X Ge, Y Chen, DWC Li, L Gong

Molecular Vision (Emory University) China , 15 October 2023

Ophthalmology

Organism: Mouse

Tissue: Eye

Pathological State: Inflammation

882
Hypoxic microenvironment determines the phenotypic plasticity and spatial distribution of cancer‐associated fibroblasts

JI Choi, EJ Cho, MJ Yang, HJ Noh, SH Park, S Kim, YS Kim, CO Sung, D Lee

Clinical and Translational Medicine (ncbi.nlm.nih.gov) South Korea , 14 October 2023

Oncology

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

883
Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland

Z Wang, L Zhang, B Li, J Song, M Yu, J Zhang, C Chen, J Zhan, H Zhang

Cell Death & Disease (Nature) China , 13 October 2023

Reproductive Medicine

Key words: Cell signalling, Differentiation

Organism: Mouse

Tissue: Breast

884
A marmoset brain cell census reveals regional specialization of cellular identities

FM Krienen, KM Levandowski, H Zaniewski, RCH Del Rosario, ME Schroeder, M Goldman, M Weinisch, A Lufservitz, VF Beja-Glasser, C Chen, Q Zhang, KY Chan, KX Li, J Sharma, D McCormack, TW Shin, A Harrahill, E Nyase, G Mudhar, A Mauermann, A Wysoker, J Nemesh, S Kashin, J Vergara, G Chelini, J Dimidschstein, S Berretta, BE Deverman, E Boyden, SA McCarroll, G Feng

Science Advances (Science) USA, Italy , 12 October 2023

Neuroscience, Zoology

Organism: Monkey

Tissue: Brain

885
A molecular landscape of quiescence and proliferation highlights the role of Pten in mammary gland acinogenesis

R Tomasin, AM Rodrigues, AC Manucci, A Bruni-Cardoso

Journal of Cell Science (The Company of Biologists) Brazil , 11 October 2023

Cell Biology

Key words: Pten, Basement membrane, Cell cycle, Extracellular matrix, Mammary gland acinogenesis, Quiescence

Organism: Mouse

Tissue: Breast

Cell Line: EpH4 cells

886
Donor bone marrow–derived macrophage engraftment into the central nervous system of patients following allogeneic transplantion

AM Loeb, SS Pattwell, S Meshinchi, A Bedalov, KR Loeb

Blood Advances (ASH Publications) USA , 10 October 2023

Hematology

Key words: Immunobiology and Immunotherapy, Transplantation

Organism: Human

Tissue: Brain

Pathological State: Hematopoietic stem cell transplantation

887
Novel ratio-expressions of genes enables estimation of wound age in contused skeletal muscle

N Li, X Liang, X Bai, X Liang, L Dang, Q Jin, J Cao, QX Du, JH Sun

International Journal of Legal Medicine (Springer) China , 07 October 2023

Osteology

Key words: Ratio-expressions of genes, Real-time PCR, Wound age estimation, Skeletal muscle

Organism: Rat

Tissue: Muscle

888
Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition

A Yu, J Hu, L Fu, G Huang, D Deng, M Zhang, Y Wang, G Shu, L Jing, H Li, X Chen, T Yang, J Wei, Z Chen, X Zu

Journal for ImmunoTherapy of Cancer (BMJ Journals) China , 06 October 2023

Oncology

Organism: Human

Tissue: Bladder

Pathological State: Cancer

889
Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition

A Yu, J Hu, L Fu, G Huang, D Deng, M Zhang, Y Wang, G Shu, L Jing, H Li, X Chen, T Yang, J Wei, J Luo

Journal for ImmunoTherapy of Cancer (BMJ Journals) China , 06 October 2023

Oncology

Key words: Tumor Microenvironment, Immunotherapy, Urinary Bladder Neoplasms

Organism: Human

Tissue: Bladder

Pathological State: Cancer

890
A comprehensive strategy to strengthen bioimaging in Africa through the Africa Microscopy Initiative

MA Reiche, CA Jacobs, JS Aaron, V Mizrahi, DF Warner, TL Chew

Nature Cell Biology (Nature) South Africa, USA , 06 October 2023

Imaging

Key words: Imaging, Microscopy

Results 881 - 890 of 3476

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