Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Read the Publication
Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

Read the Publication
AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Read the Publication
Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

Read the Publication
COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Read the Publication
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Read the Publication
Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Read the Publication
Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Read the Publication
Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Read the Publication
Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Read the Publication
Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

Read the Publication
SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Read the Publication
CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Read the Publication
previous arrow
next arrow

Filter publications

Customer Publications (A total of 3476 papers published)

Results 871 - 880 of 3476
871
Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice

AM Schmid, A Razim, M Wysmołek, D Kerekes, M Haunstetter, P Kohl, G Brazhnikov, N Geissler, M Thaler, E Krčmářová, M Šindelář, T Weinmayer, J Hrdý, K Schmidt, P Nejsum, B Whitehead, J Palmfeldt, S Schild, A Inić-Kanada, U Wiedermann, I Schabussova

Cell Communication and Signaling (Springer) Austria, Poland, Czech Republic, Denmark , 20 October 2023

Immunology

Key words: Allergic airway inflammation, Extracellular vesicles, Outer membrane vesicles, Microbiota and innate immunity, Nasal route of administration

Organism: Mouse

Tissue: Lung

Pathological State: E. coli O83 Infection

872
Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development

T Vanova, J Sedmik, J Raska, KA Cerna, P Taus, V Pospisilova, M Nezvedova, V Fedorova, S Kadakova, H Klimova, M Capandova, P Orviska, P Fojtik, S Bartova, K Plevova, Z Spacil, H Hribkova, D Bohaciakova

Cell Reports (Cell Press) Czech Republic , 20 October 2023

Neuroscience

Organism: Human

Tissue: Organoid

Pathological State: Alzheimer’s disease

873
Proteomic profiling of advanced melanoma patients to predict therapeutic response to anti-PD-1 therapy

N Zila, OM Eichhoff, I Steiner, T Mohr, A Bileck, PF Cheng, A Leitner, L Gillet, T Sajic, S Goetze, B Friedrich, P Bortel, J Strobl, R Reitermaier, SA Hogan, JM Martínez-Gómez, R Staeger, F Tuchmann, S Peters, G Stary, M Kuttke, A Elbe-Buerger, C Hoeller, R Kunstfeld, W Weninger, B Wollscheid, R Dummer, LE French, C Gerner, R Aebersold, MP Levesque, V Paulitschke

Clinical Cancer Research (AACR) Austria, Switzerland, Germany , 20 October 2023

Oncology, Pharmacology

Key words: Predictive biomarker, Immunotherapy, Serum depletion, Glycoproteomics, SWATH/DIA mass spectrometry

Organism: Human

Tissue: Skin

Pathological State: Cancer

874
TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD

L Sun, Y Chen, L Xia, J Wang, J Zhu, J Li, K Wang, K Shen, D Zhang, G Zhang, T Shi, W Chen

Oncogene (Nature) China , 20 October 2023

Oncology

Key words: Apoptosis, Extracellular matrix, Gastric cancer, Ubiquitylation

Organism: Human

Tissue: Stomach

Pathological State: Cancer

875
Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma

Z Cai, L Chen, S Chen, R Fang, X Chen, W Lei

Cell Communication and Signaling (Springer) China , 18 October 2023

Oncology

Key words: Single-cell RNA sequencing, Hypopharyngeal squamous cell carcinoma, Tumor microenvironment, Extracellular matrix cancer-associated fibroblast, Precision therapy

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

876
Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization

CY Ko, YY Lin, D Achudhan, JW Chang, SC Liu, CY Lai, YL Huang, CH Tsai, YC Fong, HT Chen, KT Lee, CC Huang, TK Chang, CH Tang

International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan , 18 October 2023

Osteology, Immunology

Key words: Omentin-1, Osteoarthritis, IL-4, M2 macrophage, Anti-inflammation

Organism: Human, Rat

Tissue: Joint Tissue

Pathological State: Osteoarthritis

877
Effect of the Functional VP1 Unique Region of Human Parvovirus B19 in Causing Skin Fibrosis of Systemic Sclerosis

DY Chen, CC Tzang, CM Liu, TM Chiu, JW Lin, PH Chuang, CW Kuo, BS Tzang, TC Hsu

International Journal of Molecular Sciences (MDPI) Taiwan , 18 October 2023

Dermatology

Key words: human parvovirus B19 (B19), systemic sclerosis (SSc), VP1 unique region (VP1u), macrophages, fibrosis

Organism: Human

Tissue: Skin

Pathological State: Human Parvovirus B19 induced Skin Fibrosis

878
Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate

O Ertunc, E Smearman, Q Zheng, JL Hicks, JA Brosnan-Cashman, T Jones, C Gomes-Alexandre, L Trabzonlu, AK Meeker, AM De Marzo, CM Heaphy

The Prostate (Wiley) USA , 17 October 2023

Oncology

Key words: chromogenic, diagnostic, in situ hybridization, prostate cancer, telomeres

Organism: Human

Tissue: Prostate

Pathological State: Cancer

879
Danggui Shaoyao San ameliorates the lipid metabolism via the PPAR signaling pathway in a Danio rerio (zebrafish) model of hyperlipidemia

Y Wang, Y Pan, M Hou, R Luo, J He, F Lin, X Xia, P Li, C He, P He, S Cheng, Z Song

Biomedicine & Pharmacotherapy (Elsevier) China , 16 October 2023

Endocrinology

Key words: Danggui Shaoyao San, Hyperlipidemia, PPAR signaling pathway, Danio rerio, Lipid metabolism

Organism: Fish

Tissue: Liver

Pathological State: Hyperlipidemia

880
Role for NLRP3 inflammasome-mediated, Caspase1-dependent response in glaucomatous trabecular meshwork cell death and regulation of aqueous humor outflow

X Feng, Z Chen, W Cheng, C Liu, Q Liu

Heliyon (Cell) China , 15 October 2023

Ophthalmology

Key words: Pyroptosis, NLRP3, ROS, Glaucoma, Human trabecular meshwork cell

Organism: Rat

Tissue: Eye

Pathological State: Glaucoma

Results 871 - 880 of 3476

LogoOrangewhite2025

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact us

About Us

TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

Keep in Touch

Be the first to hear about the latest scientific updates