Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 821 - 830 of 3476
821
Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma

J Duan, Y Zhang, R Chen, L Liang, Y Huo, S Lu, J Zhao, C Hu, Y Sun, K Yang, M Chen, Y Yu, J Ying, R Huang, X Ma, S Leaw, F Bai, Z Shen, S Cai, D Gao, J Wang, Z Wang

Cell Reports Medicine (Cell Press) China , 04 December 2023

Oncology, Pharmacology

Key words: squamous NSCLC, PD-1 blockade, biomarkers PD-L1, tumor mutational burden, gene expression signature, NRF2, tislelizumab clinical trial, immunotherapy

Organism: Human

Tissue: Lung

Pathological State: Cancer

822
SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats

A Shankar, CK Deal, S McCahon, K Callegari, T Seitz, L Yan, DM Drown, CT Williams

Chronobiology International (Taylor & Francis) USA , 04 December 2023

Nutritional science, Gastroenterology

Key words: Photoperiod, seasonal affective disorder, metabolic dysbiosis, non-alcoholic fatty liver disease

Organism: Rat

Tissue: Liver

Pathological State: Liver steatosis (fatty liver)

823
Excessive Lipid Peroxidation in Uterine Epithelium Causes Implantation Failure and Pregnancy Loss

Y Lu, Y Shao, W Cui, Z Jia, Q Zhang, Q Zhao, ZJ Chen, J Yan, B Chu, J Yuan

Advanced Science (Wiley) China , 03 December 2023

Reproductive Medicine

Organism: Mouse

Tissue: Uterus

Pathological State: Excessive Lipid Peroxidation

824
A prognostic model based on Scissor+ cancer associated fibroblasts identified from bulk and single cell RNA sequencing data in head and neck squamous cell carcinoma

G Tian, J Zhang, Y Bao, Q Li, J Hou

Cellular Signalling (Elsevier) China , 03 December 2023

Oncology

Key words: HNSCC, Fibroblasts, Scissor, scRNA-seq

Organism: Human

Pathological State: Cancer

Cell Line: GSE117973, GSE65858

825
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway

XC Wang, XL Li, XN Ma, LD Zhang, TY Han, DK Zhang

Naunyn-Schmiedeberg's Archives of Pharmacology (Springer) China , 02 December 2023

Gastroenterology, Pharmacology

Key words: Autophagy, Dihydromyricetin, Inflammatory bowel disease, Intestinal fibrosis

Organism: Mouse

Tissue: Colon

Pathological State: Intestinal fibrosis associated with inflammatory bowel disease (IBD)

826
Downregulation of N4-acetylcytidine modification in myeloid cells attenuates immunotherapy and exacerbates hepatocellular carcinoma progression

N Xu, J Zhuo, Y Chen, R Su, H Chen, Z Zhang, Z Lian, D Lu, X Wei, S Zheng, X Xu, S Wang, Q Wei

British Journal of Cancer (Nature) China , 01 December 2023

Oncology, Pharmacology

Key words: Cancer immunotherapy, Translational research

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

827
Spatiotemporal characterization of glial cell activation in an Alzheimer's disease model by spatially resolved transcriptomics

H Choi, EJ Lee, JS Shin, H Kim, S Bae, Y Choi, DS Lee

Experimental & Molecular Medicine (Nature) South Korea , 01 December 2023

Neuroscience

Key words: Alzheimer's disease, Transcriptomics, Translational research

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

828
Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury

K Štepánková, M Chudíčková, Z Šimková, N Martinez-Varea, S Kubinová, L Machová Urdzíková, P Jendelová, JF Kwok

Scientific Reports (Nature) Czech Republic, UK , 29 November 2023

Neuroscience, Pharmacology

Key words: Molecular neuroscience, Regeneration and repair in the nervous system, Synaptic plasticity

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal cord injury

829
Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development

T Vanova, J Sedmik, J Raska, KA Cerna, P Taus, V Pospisilova, M Nezvedova, V Fedorova, S Kadakova, H Klimova, M Capandova, P Orviska, P Fojtik, S Bartova, K Plevova, Z Spacil, H Hribkova, D Bohaciakova

Cell Reports (Cell) Czech Republic , 28 November 2023

Neuroscience

Organism: Human

Pathological State: Alzheimer's Disease

Cell Line: Induced Pluripotent Stem Cells

830
Low-intensity exercise training increases systolic function of heart and MHCII low cardiac resident macrophages

G Wang, L Wang, X Wang, H Ye, W Ni, W Shao, C Dai, B Liu

Heliyon (Cell Press) China , 28 November 2023

Cardiology

Key words: Cardiac macrophage, Ejection fraction, Heart, Low-intensity exerciseInnate immunity

Organism: Mouse

Tissue: Heart

Results 821 - 830 of 3476

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