Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 811 - 820 of 3421
811
CD24hiCD27+ Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer

H Huang, Y Yao, L Shen, J Jiang, T Zhang, J Xiong, J Li, S Sun, S Zheng, F Jia, J Zhou, X Yu, W Chen, J Shen, W Xia, X Shao, Q Wang, J Huang, C Ni

Clinical Cancer Research (AACR) China , 31 October 2023

Oncology, Pharmacology

Organism: Mouse

Tissue: Xenograft Tumor, Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

812
EXOSC5 maintains cancer stem cell activity in endometrial cancer by regulating the NTN4/integrin β1 signalling axis

YH Huang, WL Wang, PH Wang, HT Lee, WW Chang

International Journal of Biological Sciences (Ivy SPring) Taiwan , 31 October 2023

Oncology, Stem Cell Research

Key words: Endometrial carcinoma, cancer stem cells, c-MYC, EXOSC5, NTN4, integrin β1

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

813
Antigen-caged-adjuvant nanovaccines elicit potent humoral and cellular immune responses

K Chen, Z Zhang, J Zhang, Z Fang, W Dong, Y Wang, M Li

Nano Today (Elsevier) China , 31 October 2023

Immunology, Nanomedicine

Cell Line: murine DC2.4 cells and B16-F10 melanoma cells

814
Tumor-infiltrating platelets promote the growth of lung adenocarcinoma

X Li, M Li, Z Hu, L Zhou, M Zheng, D Jiao, J Qin, B Fu, X Zheng, H Wei

Translational Oncology (Elsevier) China , 27 October 2023

Oncology

Key words: NSCLC, Lung adenocarcinoma, Tumor-infiltrating platelets, Fibrinogen, Coagulation

Organism: Human

Tissue: Lung

Pathological State: Cancer

815
Acidosis promotes the metastatic colonization of lung cancer via remodeling of the extracellular matrix and vasculogenic mimicry

WY Shie, PH Chu, MYP Kuo, HW Chen, MT Lin, XJ Su, YL Hong, HYE Chou

International Journal of Oncology (Spandios Publications) Taiwan , 26 October 2023

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

816
Dual antibody-aided mesoporous nanoreactor for H2O2 self-supplying chemodynamic therapy and checkpoint blockade immunotherapy in triple-negative breast cancer

YT Chen, YX Luo, SH Chan, WY Chiu, HWW Yang

Journal of Nanobiotechnology (Springer) Taiwan , 24 October 2023

Oncology, Pharmacology

Key words: Triple-negative Breast cancer (TNBC), Mesoporous nanoreactors, Chemodynamic therapy (CDT), Checkpoint blockade immunotherapy, Collaborative treatment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

817
Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imaging

DE Cohn, A Forder, EA Marshall, EA Vucic, GL Stewart, K Noureddine, WW Lockwood, CE MacAulay, M Guillaud, WL Lam

Frontiers in Immunology (Frontiers Media S.A.) Canada, USA , 23 October 2023

Oncology, Imaging

Key words: tumor immune microenvironment (TIME), tumor microenvironment (TME), tumor-infiltrating lymphocytes, immune checkpoint blockade, non-cell autonomous interactions, multiplexed imaging

818
Extracellular vesicles of the probiotic E. coli O83 activate innate immunity and prevent allergy in mice

AM Schmid, A Razim, M Wysmołek, D Kerekes, M Haunstetter, P Kohl, G Brazhnikov, N Geissler, M Thaler, E Krčmářová, M Šindelář, T Weinmayer, J Hrdý, K Schmidt, P Nejsum, B Whitehead, J Palmfeldt, SSA Inić-Kanada, U Wiedermann, I Schabussova

Cell Communication and Signaling (BMC) Austria, Poland, Czech Republic, Denmark , 20 October 2023

Immunology

Key words: Allergic airway inflammation, Extracellular vesicles, Microbiota and innate immunity, Nasal route of administration, Outer membrane vesicles.

Organism: Mouse

Tissue: Lung

Pathological State: Inflammation

819
Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice

AM Schmid, A Razim, M Wysmołek, D Kerekes, M Haunstetter, P Kohl, G Brazhnikov, N Geissler, M Thaler, E Krčmářová, M Šindelář, T Weinmayer, J Hrdý, K Schmidt, P Nejsum, B Whitehead, J Palmfeldt, S Schild, A Inić-Kanada, U Wiedermann, I Schabussova

Cell Communication and Signaling (Springer) Austria, Poland, Czech Republic, Denmark , 20 October 2023

Immunology

Key words: Allergic airway inflammation, Extracellular vesicles, Outer membrane vesicles, Microbiota and innate immunity, Nasal route of administration

Organism: Mouse

Tissue: Lung

Pathological State: E. coli O83 Infection

820
Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development

T Vanova, J Sedmik, J Raska, KA Cerna, P Taus, V Pospisilova, M Nezvedova, V Fedorova, S Kadakova, H Klimova, M Capandova, P Orviska, P Fojtik, S Bartova, K Plevova, Z Spacil, H Hribkova, D Bohaciakova

Cell Reports (Cell Press) Czech Republic , 20 October 2023

Neuroscience

Organism: Human

Tissue: Organoid

Pathological State: Alzheimer’s disease

Results 811 - 820 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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