Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 811 - 820 of 3476
811
The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development

MF Chen, CC Hu, YH Hsu, YC Lin, KL Chen, SWN Ueng, Y Chang

Bone & Joint Research (The British Editorial Society of Bone & Joint Surgery) Taiwan , 12 December 2023

Osteology

Key words: Osteoarthritis, EDIL3, Chondrocyte, Extracellular matrix, Cartilage, osteoarthritic changes, cartilage tissues, extracellular matrix, chondrocytes, antibodies, interleukin, aggrecan, pro-inflammatory cytokines, OARSI, subchondral bone plate

Organism: Human

Tissue: Bone

Pathological State: Osteoarthritis

812
Differential effects of microRNAs miR‐21, miR‐99 and miR‐145 on lung regeneration and inflammation during recovery from influenza pneumonia

JWJ Ong, KS Tan, JJX Lee, JE Seet, HW Choi, SG Ler, J Gunaratne, T Narasaraju, L-T Sham, V Patzel, VT Chow

Journal of Medical Virology (Wiley Online Library) Singapore, India, UK , 12 December 2023

Pulmonology

Key words: influenza, lung regeneration, microRNAs, miR-21, mi-99a, miR-145, pneumonia, proliferating AT2 cells, RNA sequencing, stem cells

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

813
Corynoline inhibits esophageal squamous cell carcinoma growth via targeting Pim-3

Y Shi, Q Yuan, Y Chen, X Li, Y Zhou, H Zhou, F Peng, Y Jiang, Y Qiao, J Zhao, C Zhang, J Wang, K Liu, Z Dong

Phytomedicine (Elsevier) China , 12 December 2023

Oncology, Pharmacology

Key words: Proviral integration site for maloney murine leukemia virus 3, corynoline, esophageal squamous cell carcinoma, proliferation, apoptosis

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

814
Granzyme K–and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease

R Koga, T Maehara, R Aoyagi, R Munemura, Y Murakami, A Doi, M Kono, H Yamamoto, H Niiro, T Kiyoshima, M Tanabe, T Nakano, Y Matsukuma, M Kawano, JH Stone, S Pillai, S Nakamura, S Kawano

Journal of Allergy and Clinical Immunology (Elsevier) Japan, USA , 11 December 2023

Immunology

Key words: Single-cell RNA sequencing, IgG4-related disease, granzyme K, cytotoxic T cells, fibrosis, amphiregulin, double-negative (DN) B

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's Syndrome

815
Hypoxia is correlated with the tumor immune microenvironment: Potential application of immunotherapy in bladder cancer

H Chen, Y Zhang, X Chen, R Xu, Y Zhu, D He, Y Cheng, Z Wang, X Qing, K Cao

Cancer Medicine (Wiley Online Library) China , 08 December 2023

Oncology, Pharmacology

Key words: bladder cancer, hypoxia, immune checkpoint inhibitorn TLR8, tumor microenviorment

Organism: Human

Cell Line: BLCA T24

816
A breast cancer classification and immune landscape analysis based on cancer stem-cell-related risk panel

H Hu, M Zou, H Hu, Z Hu, L Jiang, D Escobar, H Zhu, W Zhan, T Yan, T Zhang

NPJ Precision Oncology (Nature) China, USA , 08 December 2023

Oncology

Key words: Cancer genomics, Prognostic markers

Organism: Human

Tissue: Breast

Pathological State: Cancer

817
Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis

YY Wang, KH Cheng, AC Hung, S Lo, PY Chen, YC Wu, MF Hou, SSF Yuan

International Journal of Oncology (Spandios Publications) Taiwan , 07 December 2023

Oncology, Molecular Biology

Organism: Human

Tissue: Breast

Pathological State: Cancer

818
Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer

W Tang, G Li, Q Lin, Z Zhu, Z Wang, Z Wang

Journal of Translational Medicine (Springer) China , 07 December 2023

Oncology

Key words: Gastric cancer, Cholersterol metabolism, Metabolic subtypes, Immunotheerapy, Prognostic signature, Biomarkers

Organism: Human

Tissue: Stomach

Pathological State: Cancer

819
Pro‐inflammatory cytokine IL‐6 regulates LMO4 expression in psoriatic keratinocytes via AKT/STAT3 pathway

Z Tu, W Wei, Q Xiang, W Wang, S Zhang, H Zhou

Immunity, Inflammation and Disease (Wiley Online Library) China , 06 December 2023

Dermatology, Molecular Biology

Key words: AKT, interleukin‐6, LMO4, psoriasis, STAT3

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

Cell Line: HaCaT cells

820
ALDOB/KAT2A interactions epigenetically modulate TGF-β expression and T cell functions in hepatocellular carcinogenesis

C Yin, C Zhang, Y Wang, G Liu, N Wang, N Liang, L Zhang, Q Tu, J Lv, H Jiang, H Ma, C Du, M Li, X He, S Chen, J Guo, S Li, J Qin, N Li, Y Tao, H Yin

Hepatology (AASLD) China , 05 December 2023

Hepathology, Oncology

Organism: Human, Mouse

Tissue: Liver

Pathological State: Cancer

Results 811 - 820 of 3476

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