Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 771 - 780 of 3476
771
Microbial colony sequencing combined with metabolomics revealed the effects of chronic hexavalent chromium and nickel combined exposure on intestinal inflammation in mice

Y Gu, S Zheng, C Huang, X Cao, P Liu, Y Zhuang, G Li, G Hu, X Gao, X Guo

Science of The Total Environment (Elsevier) China , 18 January 2024

Gastroenterology

Key words: Hexavalent chromium,Nickel, Inflammatory response, Microbiome, Metabolomics

Organism: Mouse

Tissue: Intestine

Pathological State: Inflammation

772
Analysis of organoid and immune cell co-cultures by machine learning-empowered image cytometry

P Stüve, B Nerb, S Harrer, M Wuttke, M Feuerer, H Junger, E Eggenhofer, B Lungu, S Laslau, U Ritter P Stüve, B Nerb, S Harrer, M Wuttke, M Feuerer, H Junger, E Eggenhofer, B Lungu, S Laslau, U Ritter

Frontiers in Medicine (Frontiers Media S.A.) Germany, Romania , 17 January 2024

Medical Image Analysis, Machine Learning

Organism: Human

Cell Line: Recombinant proteins

773
Salvia miltiorrhiza Bunge extract and Przewalskin ameliorate Bleomycin-induced pulmonary fibrosis by inhibition of apoptosis, oxidative stress and collagen …

M Zeng, A Feng, Y Ren, Q Zhang, R Wang, B Zhang, M Liu, P Guo, Y Zhang, J Lyu, X Zheng

Phytomedicine (Elsevier) China , 17 January 2024

Pharmacology, Pulmonology

Key words: Salvia miltiorrhiza Bunge (Labiatae), Przewalskin, Pulmonary fibrosis, Transcriptome sequencing, SPR ligand fishing

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

774
Spatial and Single-Cell Transcriptomics Reveal a Cancer-Associated Fibroblast Subset in HNSCC That Restricts Infiltration and Antitumor Activity of CD8+ T Cells

C Li, H Guo, P Zhai, M Yan, C Liu, X Wang, C Shi, J Li, T Tong, Z Zhang, H Ma, J Zhang

Cancer Research (AACR) China , 16 January 2024

Oncology

Key words: Lymphocyte biology

Organism: Human

Pathological State: Cancer

Cell Line: HNSCC 

775
Myeloid zfhx3 deficiency protects against hypercapnia-induced suppression of host defense against influenza A virus

SM Casalino-Matsuda, F Chen, FJ Gonzalez-Gonzalez, H Matsuda, A Nair, H Abdala- Valencia, GRS Budinger, JT Dong, GJ Beitel, PHS Sporn

JCI insight (American Society for Clinical Investigation) USA, China , 16 January 2024

Immunology, Virology

Key words: Influenza, Innate immunity, Macrophages

Organism: Mouse

Tissue: Lung

776
The effector program of human CD8 T cells supports tissue remodeling

M Delacher, L Schmidleithner, M Simon, P Stüve, L Sanderink, A Hotz-Wagenblatt, M Wuttke, K Schambeck, B Ruhland, V Hofmann, S Bittner, U Ritter, A Pant, SS Helbich, M Voss, NA Lemmermann, L Bessiri-Schake, T Bohn, A Eigenberger, AN Menevse, C Gebhard, N Strieder, H Abken, M Rehli, J Huehn, P Beckhove, T Hehlgans, H Junger, EK Geissler, L Prantl, JM Werner, C Schmidl, B Brors, CD Imbusch, M Feuerer

Journal of Experimental Medicine (Rockerfeller University Press) Germany , 16 January 2024

Oncology, Pharmacology

Organism: Human

Tissue: Liver

Pathological State: Cancer

777
Spatial and Single-Cell Transcriptomics Reveal a Cancer-Associated Fibroblast Subset in HNSCC That Restricts Infiltration and Antitumor Activity of CD8+ T Cells

C Li, H Guo, P Zhai, M Yan, C Liu, X Wang, C Shi, J Li, T Tong, Z Zhang, H Ma, J Zhang

Cancer Research (AACR) China , 16 January 2024

Oncology

Key words: Lymphocyte biology

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

778
FMRP regulation of aggrecan mRNA translation controls perineuronal net development

HM Van't Spijker, JD Richter

Journal of Neurochemistry (Wiley) USA, UK , 15 January 2024

Neuroscience

Key words: aggrecan, FMRP, fragile X syndrome, perineuronal net

Organism: Mouse

Tissue: Brain

779
The microenvironment cell index is a novel indicator for the prognosis and therapeutic regimen selection of cancers

XY Yang, N Chen, Q Wen, Y Zhou, T Zhang, J Zhou, CH Liang, LP Han, XY Wang, QM Kang, XX Zheng, XJ Zhai, HY Jiang, TH Shen, JW Xiao, YX Zou, Y Deng, S Lin, JJ Duan, J Wang, SC Yu

Journal of Translational Medicine (Springer) China , 13 January 2024

Oncology

Key words: Triple-negative breast cancer, Tumor microenvironment, Cell infiltration, Spatial location, Prognosis prediction, Therapeutic regimen

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

780
SHCBP1 Overexpression Aggravates Pancreatitis by Triggering the Loss of Primary Cilia

L Li, H Zhao, Z Li, W Shi, Z Jiao

DNA and Cell Biology (Mary Ann) China , 12 January 2024

Cell Biology

Key words: LPS; SHCBP1; acute pancreatitis; cerulein; primary cilia.

Organism: Mouse

Tissue: Pancreas

Pathological State: Aggravates Pancreatitis

Results 771 - 780 of 3476

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