Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Read the Publication
Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

Read the Publication
AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Read the Publication
Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

Read the Publication
COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Read the Publication
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Read the Publication
Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Read the Publication
Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Read the Publication
Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Read the Publication
Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Read the Publication
Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

Read the Publication
SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Read the Publication
CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Read the Publication
previous arrow
next arrow

Filter publications

Customer Publications (A total of 3476 papers published)

Results 731 - 740 of 3476
731
NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis

CY Lin, KT Lee, YY Lin, CH Tsai, CY Ko, YC Fong, SM Hou, WL Chen, CC Huang, CH Tang

International Immunopharmacology (Elsevier) Taiwan , 21 February 2024

Neuroscience

Key words: NGF; Rheumatoid arthritis; ICAM-1; M1 macrophage; TrkA

Organism: Human

Tissue: Joint Tissue

Pathological State: Rheumatoid arthritis

732
Tumor histoculture captures the dynamic interactions between tumor and immune components in response to anti-PD1 in head and neck cancer

NP Basak, K Jaganathan, B Das, O Muthusamy, R M, R Malhotra, A Samal, M Nath, G MS, AP Shankar, P BV, V Pillai, M BV, J C, V K, GS K, S Govindan, S V, Jy, K R, C Bhowal, U Kumar, G K, M Malhotra, S Sankaran

Nature Communications (Nature) India , 21 February 2024

Oncology, Immunology

Key words: Cancer models, Head and neck cancer, Tumour immunology

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

733
CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma

S Wei, Y Zhang, BE Kang, W Park, H Guo, S Nam, JS Kang, JH Jeong, Y Jo, D Ryu, Y Jiang, KT Ha

BMB Reports () China, South Korea , 20 February 2024

Oncology

Key words: Clinical biomarker, Cyclin-dependent kinase inhibitor 2, Hepatocellular carcinoma, T cell exhaustion, Tissue microarray

734
TIMP3/Wnt axis regulates gliosis of Müller glia

JH Hung, PH Tsai, WJF Aala, CC Chen, SH Chiou, TW Wong, KJ Tsai, SM Hsu, LW Wu

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Taiwan , 17 February 2024

Ophthalmology

Key words: Müller cell; Müller glia; Gliosis; Age-related macular degeneration (AMD); Laser-induced choroidal neovascularization (CNV); Proliferative diabetic retinopathy (PDR)

Organism: Mouse

Tissue: Eye

Pathological State: Gliosis

Cell Line: MIO-M1

735
Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model

YC Shyu, TS Huang, HS Chiu, P Sumazin, XY Lin, PC Liao, CC Liou, FC Hsu, JS Lin, CC Hsu, PH Hsu, CC Sun, CT Chen

International Journal of Molecular Science (MDPI) Taiwan, USA , 17 February 2024

Regenerative Medicine

Key words: negative pressure wound therapy (NPWT); dickkopf-related-protein1 (DKK-1); hair follicle stem cells (HFSCs); epidermal cells; inflammatory

Organism: Mouse

Tissue: Skin

Pathological State: Wound

736
CXCR5+TIM-3-PD-1+ stem-like cytotoxic CD8+ T cells: elevated in chronic rhinosinusitis and associated with disease severity

Z Liu, Z Zhao, H Xie, N Lu, J Liu, Q Jiao

Frontiers in Immunology (Frontiers) China , 15 February 2024

Immunology

Key words: chronic rhinosinusitis, PD-1+, CXCR5+, TIM-3-, stem-like CD8+ T cells

Organism: Human

Tissue: Mucosa

Pathological State: Inflammation

737
INHBA (+) cancer-associated fibroblasts generate an immunosuppressive tumor microenvironment in ovarian cancer

Y Hu, MS Recouvreux, M Haro, E Taylan, BH Taylor-Harding, AE Walts, BY Karlan, S Orsulic

NPJ Precision Oncology (Nature) USA , 15 February 2024

Oncology

Key words: Cell biology, Gynaecological cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

738
Quercetin Promotes Apoptosis of Gastric Cancer Cells through the EGFR-ERK Signaling Pathway

, B Zhang, J Zhu, X Wei, R Huang, Y Zhang, Q Jin

Journal of Food Biochemistry (Hindawi) China , 13 February 2024

Oncology

Organism: Human

Pathological State: Cancer

Cell Line: MKN-45

739
A Divalent Chikungunya and Zika Nanovaccine with Thermostable Self‐assembly Multivalent Scaffold LS‐SUMO

Q Li, J Zhang, Q Deng, C Liao, J Qian, Z Chen, J Lu

Advanced Healthcare Materials (Wiley) China , 10 February 2024

Virology

Organism: Mouse

Tissue: Kidney, Liver, Skin, Joint Tissue

Pathological State: Chikungunya and Zika Infection

740
Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner

J Zhao, C Yao, Y Qin, H Zhu, H Guo, B Ji, X Li, N Sun, R Li, Y Wu, K Zheng, Y Pan, T Zhao, J Yang

Cell Death & Disease (Nature) China , 08 February 2024

Oncology

Key words: Cancer immunotherapy, Immunotherapy

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

Results 731 - 740 of 3476

LogoOrangewhite2025

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact us

About Us

TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

Keep in Touch

Be the first to hear about the latest scientific updates