Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

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Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 721 - 730 of 3476
721
Immune microenvironment heterogeneity of concurrent adenocarcinoma and squamous cell carcinoma in multiple primary lung cancers

J Zhang, Y Huang, Y Han, D Dong, Y Cao, X Chen, D Liu, X Cheng, D Sun, H Li, Y Zhang

NPJ Precision Oncology (Nature) China , 29 February 2024

Oncology

Key words: Cnacer genomics, Cancer microenvironment, Non-small-cell lung cancer, Tumour immunology

Organism: Human

Tissue: Lung

Pathological State: Cancer

722
Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5

L Ding, Y Sun, Y Liang, J Zhang, Z Fu, C Ren, P Li, W Liu, R Xiao, H Wang, Z Zhang, X Yue, C Li, Z Wu, Y Feng, X Liang, C Ma, L Gao

Advanced Science (Wiley) China , 28 February 2024

Endocrinology

Key words: Gαs ubiquitination; Tipe1; deubiquitinase USP5; diabetes; islet β cell

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

723
TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis

Y Li, S Luan, C Ruan, W Li, X Zhang, Z Ran, W Bi, Y Tong, L Gao, J Zhao, Y Li, Z He

Biochemical and Biophysical Research Communications (Elsevier) China , 28 February 2024

Neuroscience

Key words: Thyroid-stimulating hormone receptor (TSHR); Memory; Cognitive impairment; Wnt5a; Neurogenesis

Organism: Mouse

Tissue: Brain

Pathological State: Subclinical hyperthyroidism

724
Peripheral neural interfaces: Skeletal muscles are hyper-reinnervated according to the axonal capacity of the surgically rewired nerves

V Tereshenko, DC Dotzauer, M Schmoll, L Harnoncourt, GC Rojas, L Gfrerer, KR Eberlin, WG Austen Jr., R Blumer, D Farina, OC Aszmann

Science Advances (Science) USA, Austria, UK , 28 February 2024

Neuroscience

Organism: Rat

Tissue: Nerve, Muscle

725
Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice

J Hu, K He, Y Yang, C Huang, Y Dou, H Wang, G Zhang, J Wang, C Niu, G Bi, L Zhang, S Zhu

Cell Reports (Cell Press) China , 26 February 2024

Neuroscience, Nutritional science

Key words: CP: Microbiology; CP: Neuroscience; amino acid formula; depression; microbiota.

Organism: Mouse

Tissue: Colon, Brain

726
Combined inhibition of HER2 and VEGFR synergistically improves therapeutic efficacy via PI3K-AKT pathway in advanced ovarian cancer

W Li, K Zhang, W Wang, Y Liu, J Huang, M Zheng, L Li, X Zhang, M Xu, G Chen, L Wang, S Zhang

Journal of Experimental & Clinical Cancer Research (Springer) China , 26 February 2024

Oncology

Key words: HER2, VEGFR, Antibody drug conjugate, RC48, Cediranib Maleate, Synergetic effect, Ovarian cancer

Organism: Human

Pathological State: Cancer

Cell Line: A2780, OVCAR-3, SK-OV-3, HO-8910PM, UM-UC-3

727
Negative impact of ratio of the microvascular area to tumor area on the response to EGFR-TKI in non-small cell lung cancer with an EGFR mutation

M Anai, K Saruwatari, K Imamura, K Fujino, T Jodai, S Sakata, S Iyama, Y Tomita, S Saeki, H Ichiyasu, K Ikeda, M Suzuki, T Sakagami

Journal of Thoracic Disease (AME) Japan , 26 February 2024

Oncology

Key words: Non-small cell lung cancer (NSCLC), epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), microvascular area, microvascular density (MVD)

Organism: Human

Tissue: Lung

Pathological State: Cancer

728
Use of Atrial Fibrillation Electrograms and T1/T2 Magnetic Resonance Imaging to Define the Progressive Nature of Molecular and Structural Remodeling: A New Paradigm Underlying the Emergence of Persistent Atrial Fibrillation

M Rottmann, S Yoo, A Pfenniger, A Mikhailov, B Benefield, DA Johnson, W Zhang, AK Ghosh, D Kim, R Passman, BP Knight, DC Lee, R Arora

Journal of the American Heart Association (American Heart Association) USA , 23 February 2024

Cardiology

Key words: MRI; arrhythmias; atrial fibrillation; fibrosis; mapping; reactive oxygen species

Organism: Dog

Tissue: Heart

Pathological State: Atrial Fibrillation

729
Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice

Q Wu, Q Ren, X Wang, H Bai, D Tian, G Gao, F Wang, P Yu, YZ Chang

CNS Neuroscience & Therapeutics (Wiley) China , 22 February 2024

Neuroscience

Key words: Per1; aging; circadian rhythm; clock genes; iron

Organism: Mouse

Tissue: Brain

730
RBM3 Promotes Anti-inflammatory Responses in Microglia and Serves as a Neuroprotective Target of Ischemic Stroke

J Zhao, S Liu, K Li, Y Yang, Y Zhao, X Zhu

Molecular Neurobiology (Springer) China , 22 February 2024

Neuroscience

Key words: Ischemic stroke, Cold-inducible RNA-binding proteins, Small molecule zr17-2, Neuroprotection, Neuroinflammation, Microglia

Organism: Mouse

Tissue: Brain

Pathological State: Ischemic Stroke

Results 721 - 730 of 3476

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