Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 691 - 700 of 3476
691
Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome

AJ Diaz-Jimenez, M Ramos, B Helm, S Chocarro, DL Frey, S Agrawal, K Somogyi, U Klingmüller, J Lu, R Sotillo

Drug Resistance Updates (Elsevier) Germany , 19 March 2024

Oncology

Key words: ALK, Lung Cancer, SRC, Resistance, Targeted therapy

Organism: Mouse

Pathological State: Cancer

Cell Line: Eml4-Alk

692
Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is suppressed by hsa-miR-200b-3p

J Shi, F Ding, D Dai, X Song, X Wu, D Yan, X Han, G Tao, W Dai

Scientific Reports (Nature) China , 19 March 2024

Oncology

Key words: Cancer. Cancer prevention, Cancer therapy, Cell growth, Cell proliferation, Gastrointestinal cancer

Organism: Human

Tissue: Stomach

Pathological State: Cancer

693
Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer

NCW Ho, JYY Yap, Z Zhao, Y Wang, K Fernando, CH Li, XL Kwang, HS Quah, C Arcinas, NG Iyer, ELS Fong

Advanced Science (Wiley) Singapore , 17 March 2024

Oncology

Key words: CAF heterogeneity; cancer-associated fibroblasts; hydrogel; inflammatory CAF; myofibroblastic CAF

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

694
Computer-assisted image analysis of preexisting histological patterns of the cephalic vein to predict wrist arteriovenous fistula non-maturation

JW Chen, M Ting, PY Chang, CJ Jung, CH Chang, SY Fang, LW Liu, KJ Yang, SH Yu, YS Chen, NH Chi, RB Hsu, CH Wang, IH Wu, HY Yu, CY Chan

Journal of the Formosan Medical Association (Elsevier) Taiwan , 16 March 2024

Medical Image Analysis

Key words: Arteriovenous fistula; Computer-assisted image interpretation; Histological technique; Vascular smooth muscle

Organism: Human

Tissue: Blood Vessels

Pathological State: Arteriovenous Fistula

695
PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma

G Shu, M Chen, W Liao, L Fu, M Lin, C Gui, J Cen, J Lu, Z Chen, J Wei, W Chen, Y Wang, J Zhu, T Zhao, X Liu, J Jing, GC Liu, Y Pan, J Luo, J Zhang

Cancer Research (AACR) China , 15 March 2024

Oncology

Organism: Human

Pathological State: Cancer

Cell Line: Renal Cell Carcinoma

696
Targeting ESE3/EHF with Nifurtimox inhibits CXCR2+ neutrophil infiltration and overcomes pancreatic cancer resistance to chemotherapy and immunotherapy

Y Xie, T Zhou, X Li, K Zhao, W Bai, X Hou, Z Liu, B Ni, Z Zhang, J Yan, Y Wang, W Jiang, H Wang, A Chang, S Gao, T Zhao, S Yang, C Huang, J Liu, J Hao

Gastroenterology (Elsevier) China, USA , 15 March 2024

Oncology, Pharmacology

Key words: CXCL1; CXCR2(+) Neutrophils; EHF; Nifurtimox; Pancreatic Cancer.

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

697
YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia

Z Liu, S Li, S Chen, J Sheng, Z Li, T Lv, W Yu, Y Fan, J Wang, W Liu, S Hu, J Jin

Iscience (Cell Press) China , 15 March 2024

Urology

Key words: Biochemistry; Cell biology; Molecular biology; Prostate disease

Organism: Human

Tissue: Prostate

Pathological State: Benign Prostatic Hyperplasia

698
Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iPSNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice

YZ Wang, T Perez-Rosello, SN Smukowski, DJ Surmeier, JN Savas

Molecular Psychiatry (Nature) USA , 14 March 2024

Neuroscience

Key words: Biological techniques, Neuroscience

Organism: Mouse

Tissue: Brain

699
Nuinsseg: a fully annotated dataset for nuclei instance segmentation in h&e-stained histological images

A Mahbod, C Polak, K Feldmann, R Khan, K Gelles, G Dorffner, R Woitek, S Hatamikia, I Ellinger

Scientific Data (Nature) Austria , 14 March 2024

Medical Image Analysis, Machine Learning

Key words: Computational moderls, Data acquisition, Data processing, Super-resolution microscopy

Organism: Human, Mouse

700
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

ZY Li, YQ Mao, Q Hua, YH Sun, HY Wang, XG Ye, JX Hu, YJ Wang, M Jiang

World Journal of Gastroenterology (Baishideng Publishing Group) China , 14 March 2024

Gastroenterology

Key words: Diarrhea-predominant irritable bowel syndrome, Serotonin receptor 2B, Transient receptor potential vanilloid type-1, Visceral hypersensitivity, Abdominal pain

Organism: Human

Tissue: Colon

Results 691 - 700 of 3476

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