Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 681 - 690 of 3476
681
Tissue-resident cytotoxic T cell infiltration predicts metachronous colorectal cancer metastasis

R Cohen, T Lee-Pullen, T Miller, S Pirasteh, C Platell, K Meehan, K Fuller, M McCoy

Cancer Research (AACR) Australia , 22 March 2024

Oncology, Immunology

682
A Mechanistic and Preclinical Assessment of BioRestore Bioactive Glass as a Synthetic Bone Graft Extender and Substitute for Osteoinduction and Spine Fusion

EJ Fred, S Minardi, AM Goodwin, TS Nandurkar, MA Plantz, JG Lyons, JT Paul, JP Foley, AJ Wintring, AA Furman, S Jeong, C Yun, SR Stock, WK Hsu, EL Hsu

Clinical Spine Surgery (Lippincott Williams & Wilkins) USA , 22 March 2024

Osteology

Key words: spinal fusion, bioactive glass, bone graft extender, bone graft substitute, iliac crest bone graft, osteoinductivity

Organism: Rat

Tissue: Bone

683
Panax notoginseng saponins improve oral submucous fibrosis by inhabiting the Wnt/β-catenin signal pathway

L Hu, J He, T Zhang, S Pan, H Zou, K Lian, J Guo, T Qun

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology (Elsevier) China , 22 March 2024

Pharmacology

Organism: Rat

Tissue: Mucosa

Pathological State: Oral Submucous Fibrosis

684
Effects of chronic Cr and Ni co-exposure on liver inflammation and autophagy in mice by regulating the TLR4/mTOR pathway

X Cao, S Zheng, Y Zeng, Y Shi, J Du, C Huang, Y Shen, P Liu, X Guo, X Gao

Science of The Total Environment (Elsevier) China , 22 March 2024

Toxicology

Key words: Chromium; Liver toxic effect; Mice; Nickel; TLR4/mTOR pathway.

Organism: Mouse

Tissue: Liver

685
Rational evolution for altering the ligand preference of estrogen receptor alpha

R Eerlings, P Gupta, XY Lee, T Nguyen, S El Kharraz, F Handle, E Smeets, L Moris, W Devlies, B Vandewinkel, I Thiry, D Tien Ta, A Gorkovskiy, K Voordeckers, E Henckaerts, VB Pinheiro, F Claessens, KJ Verstrepen

Protein Science (Wiley) Belgium , 21 March 2024

Endocrinology

Key words: directed evolution, estrogen receptor, nuclear receptors, Saccharomyces cerevisiae, synthetic biology, tamoxifen

Organism: Mouse

Tissue: Heart

686
PGR-KITLG signaling drives a tumor-mast cell regulatory feedback to modulate apoptosis of breast cancer cells

Z Yang, H Chen, S Yin, H Mo, F Chai, P Luo, Y Li, L Ma, Z Yi, Y Sun, Y Chen, J Wu, W Wang, T Yin, J Zhu, C Shi, F Zhang

Cancer Letters (Elsevier) China , 20 March 2024

Oncology

Key words: Apoptosis; Breast cancer; GRN; Mast cells; PGR-KITLG signaling.

Organism: Human

Tissue: Breast

Pathological State: Cancer

687
A subpopulation of luminal progenitors secretes pleiotrophin to promote angiogenesis and metastasis in inflammatory breast cancer

M Zhang, K Zhou, Z Wang, T Liu, LE Stevens, F Lynce, WY Chen, S Peng, Y Xie, D Zhai, Q Chen, Y Shi, H Shi, Z Yuan, XL 0, J Xu, Z Cai, J Guo, N Shao, Y Lin

Cancer Research (AACR) China, USA , 20 March 2024

Oncology

Key words: Inflammatory breast cancer; PTN; Luminal progenitor cell; Angiogenesis; Metastasis

Organism: Human

Tissue: Breast

Pathological State: Cancer

688
Inhibition of phospholipase D promotes neurological function recovery and reduces neuroinflammation after spinal cord injury in mice

H Ke, F Bai, Z Li, Y Zhu, C Zhang, Y Li, Z Talifu, Y Pan, W Liu, X Xu, F Gao, D Yang, L Du, Y Yu, J Li

Frontiers in Cellular Neuroscience (Frontiers) China , 20 March 2024

Neuroscience

Key words: neuroinflammation; phospholipase D; protein microarray analysis; spinal cord injury; transcriptome sequencing analysis

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Inflammation

689
Aerobic Exercise Modulates Proteomic Profiles in Gastrocnemius Muscle of db/db Mice, Ameliorating Sarcopenia

YC Huang, MR Sanotra, CC Huang, YJ Hsu, CC Liao

Life (MDPI) Taiwan , 20 March 2024

Endocrinology

Key words: aerobic exercise; db/db mice; ECM remodeling; gastrocnemius muscle; metabolic pathways; muscle regeneration; proteomic profiling; T2DM-induced sarcopenia

Organism: Mouse

Tissue: Muscle

690
Metabolic mechanism and pharmacological study of albendazole in secondary hepatic alveolar echinococcosis (HAE) model rats

C Li, Y Zhang, M Pang, Y Zhang, C Hu, H Fan

Antimicrobial Agents and Chemotherapy (American Society for Microbiology) China , 19 March 2024

Parasitology

Key words: albendazole; alveolar echinococcosis; hepatic drug-metabolizing enzyme.

Organism: Rat

Tissue: Liver

Pathological State: Bactirial Infection

Results 681 - 690 of 3476

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