Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 651 - 660 of 3476
651
Versatile tissue‐injectable hydrogels capable of the extended hydrolytic release of bioactive protein therapeutics

ES Nealy, SJ Reed, SM Adelmund, BA Badeau, JA Shadish, EJ Girard, K Brasel, FJ Pakiam, AJ Mhyre, JP Price, S Sarkar, V Kalia, CA DeForest, JM Olson

Bioengineering & Translational Medicine (Wiley) USA , 15 April 2024

Biomaterials, Pharmacology

Key words: drug delivery, extended release, hydrogels, immuno-oncology, loco-regional, proteins, sortase

Organism: Mouse

Tissue: Brain

652
Th17 cells secrete TWEAK to trigger epithelial-mesenchymal transition and promote colorectal cancer liver metastasis

X Liu, X Wang, Q Yang, L Luo, Z Liu, X Ren, K Lei, S Li, Z Xie, G Zheng, Y Zhang, Y Hao, Q Zhou, Y Hou, F Fang, W Song, J Cui, J Ma, W Xie, S Shen, C Tang, S Peng, J Yu, M Kuang, X Song, F Wang, L Xu

Cancer Research (AACR) China , 15 April 2024

Oncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

653
Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer

H Hu, H Zhu, W Zhan, B Hao, T Yan, J Zhang, S Wang, X Xu, T Zhang

Inflammation Research (Springer) China , 15 April 2024

Oncology

Key words: Breast cancer, CD24, CD8+ T cell, Tumor immune microenvironment, Immunotherapy

Organism: Human

Tissue: Breast

Pathological State: Cancer

654
Vaginal Microbiota and Proinflammatory Status in Patients with Polycystic Ovary Syndrome: An Exploratory Study

ME Espinosa, A Melo, M Leon, EV Bautista-Valarezo, F Zambrano, P Uribe, A Bravo, A Taubert, C Hermosilla, V Iturrieta, R Sánchez

Journal of Clinical Medicine (MDPI) Chile, Ecuador, Germany , 15 April 2024

Gynaecology

Key words: polycystic ovary syndrome; phenotypes; vaginal inflammatory reaction; vaginal microbiota; neutrophil extracellular traps (NETs)

Organism: Human

Pathological State: Polycystic Ovary Syndrome

Cell Line: Vaginal Discharge

655
Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice

X Wang, Y Jin, C Di, Y Zeng, Y Zhou, Y Chen, Z Pan, Z Li, W Ling

Nutrients (MDPI) China , 14 April 2024

Nutritional science

Key words: dietary silymarin intervention; NAFLD; gut microbiota; fecal microbiome transplantation (FMT); bile acids; secondary bile acids; metabolomics analysis

Organism: Mouse

Tissue: Liver

Pathological State: Non-Alcoholic Fatty Liver Disease

656
A novel perspective on di-hexyl phthalate (2-ethylhexyl)-induced reproductive toxicity in females: Lipopolysaccharide synergizes with mono-2-ethylhexyl ester to cause inflammatory apoptosis rather than autophagy in ovarian granulosa cells

B Xu, Z Zhang, H Yang, L Ding, W Dai, L Liu, X Du, X Fu, X Pei

Ecotoxicology and Environmental Safety (Elsevier) China , 13 April 2024

Reproductive Medicine

Key words: Apoptosis; Autophagy; Di-hexyl phthalate (2-ethylhexyl); Inflammation; NF-κB pathway; Ovarian Granulosa Cells

Organism: Mouse

Tissue: Ovaries

Pathological State: Inflammation

657
Macrophage-coated tumor cluster aggravates hepatoma invasion and immunotherapy resistance via generating local immune deprivation

J Ning, Y Ye, H Shen, R Zhang, H Li, T Song, R Zhang, P Liu, G Chen, H Wang, F Zang, X Li, J Yu

Cell Reports Medicine (Cell Press) China , 12 April 2024

Oncology, Immunology

Key words: M2BP; T cell exclusion; hepatocellular carcinoma; immune checkpoint inhibitors; immunological evasion; macrophages coated tumor cluster; tumor-associated macrophages

Organism: Human, Mouse

Tissue: Lung

Pathological State: Cancer

658
Combined therapy of dabrafenib and an anti-HER2 antibody–drug conjugate for advanced BRAF-mutant melanoma

W Li, C Zheng, X Xu, Y Xia, K Zhang, A Huang, X Zhang, Y Zheng, G Chen, S Zhang

Cellular &Molecular Biology Letters (Springer) China , 10 April 2024

Oncology, Dermatology

Key words: HER2, RC48, Antibody drug conjugate, Dabrafenib, Synergetic effect, Melanoma

Organism: Human

Pathological State: Cancer

Cell Line: A2058, SK-MEL-28

659
Identification of neutrophils and eosinophils in upper airway mucosa with immunofluorescence multiplex image cytometry

AI Giotakis, J Dudas, R Glueckert, E Buechel, H Riechelmann

Histochemistry and Cell Biology (Springer) Austria , 10 April 2024

Immunology, Imaging

Key words: Image cytometry, Fluorescent antibody technique, Sinusitis, Leukocytes, Neutrophils, Eosinophils

Organism: Human

Tissue: Mucosa

Pathological State: Chronic rhinosinusitis

660
The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation

AR Murphy, H Asif, H Cingoz, FA Gourronc, JA Ankrum, AJ Klingelhutz, JJ Kim

The Journal of Clinical Endocrinology & Metabolism (Oxford Academic) USA , 10 April 2024

Physiology

Key words: endometrium, obesity, adiposity, metallothionein, progesterone

Organism: Human

Tissue: Endometrium

Pathological State: Adipositas

Results 651 - 660 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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