Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 611 - 620 of 3421
611
Alkali injury–induced pathological lymphangiogenesis in the iris facilitates the infiltration of T cells and ocular inflammation

Z Liu, K Liu, S Shi, X Chen, X Gu, W Wang, K Mao, R Yibulayi, W Wu, L Zeng, W Zhou, X Lin, F Zhang, B Lou

The Journal of Clinical Investigation (American Society for Clinical Investigation) China , 08 April 2024

Immunology, Ophthalmology

Key words: Immunology; Lymph; Ophthalmology; Retinopathy; T cells.

Organism: Mouse

Tissue: Eye

Pathological State: Inflammation

612
Continuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains

S Feng, T Zhang, Z He, W Zhang, Y Chen, C Yue, N Jing

Cell Regeneration (Springer) China , 07 April 2024

Neuroscience

Key words: Cell transplantation; Human induced neural stem/progenitor cells (iNPCs); Immune response; Non-human primate brain; Xenograft

Organism: Monkey

Tissue: Brain

Pathological State: Immunosuppressant

613
Integrated analysis of scRNA-seq and bulk RNA-seq reveals that GPRC5A is an important prognostic gene in pancreatic cancer and is associated with B-cell Infiltration in pancreatic cancer

C Dong, H Ma, N Mi, W Fu, J Yi, L Gao, H Wang, Y Ren, Y Lin, F Han, Z Chen, W Zhou

Frontiers in Oncology (Frontiers) China , 03 April 2024

Oncology

Key words: pancreatic cancer, single-cell, immune infiltration, B cell, Gprc5a

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

614
A potential bivalent mRNA vaccine candidate protects against both RSV and SARS-CoV-2 infections

N Wu, J Zhang, Y Shen, X Zhang, J Zhou, Y Wu, E Li, X Meng, X Chuai, S Chiu, Y Wang

Molecular Therapy (Cell Press) China , 03 April 2024

Virology

Key words: antigen competition; bivalent vaccine; lipid nanoparticle; mRNA; respiratory infectious disease; respiratory syncytial virus; severe acute respiratory syndrome coronavirus 2.

Organism: Mouse, Other Rodent

Tissue: Lung, Mucosa

Pathological State: Viral Infection

615
Shenyu ningshen tablet reduced neuronal damage in the hippocampus of chronic restraint stress model rat by inhibiting A1-reactive astrocytes

Y Wang, S Li, M Chen, M Zeng, L Zhou, R Yao, B Pang, Y Xu, S Cao, S Guo, X Cui

Heliyon (Cell Press) China , 02 April 2024

Neuroscience

Key words: A1 astrocyte; CRS rat model; Depression; Neuron; SYNS tablet

Organism: Rat

Tissue: Brain

Pathological State: Stress

616
Abrus cantoniensis Hance alleviates APAP-triggered acute liver damage via inhibiting the MAPK and NF-κB signaling pathways in mice

C Zhang, H Gu, C Tu, Y Yang, D Miao, L Chen

Journal of Functional Foods (Elsevier) China , 02 April 2024

Nutritional science

Key words: Abrus cantoniensis Hance, Hepatoprotective, APAP, Oxidative stress, MAPK, NF-κB

Organism: Mouse

Tissue: Liver

Pathological State: Inflammation, Necrosis

617
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response

H Yang, X Wu, X Li, W Zang, Z Zhou, Y Zhou, W Cui, Y Kou, L Wang, A Hu, L Wu, Z Yin, Q Chen, Y Chen, Z Huang, Y Wang, B Gu

Nature Communications (Nature) China , 02 April 2024

Immunology

Key words: Antimicrobal responses, Bacterial host response, Interleukins, Parasite host response, T-helper 1 cells

Organism: Mouse

Tissue: Colon

Pathological State: Bacterial Infection

618
Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells

C Bangert, N Alkon, S Chennareddy, T Arnoldner, JP Levine, M Pilz, MA Medjimorec, J Ruggiero, ER Cohenour, C Jonak, W Damsky, J Griss, PM Brunner

Nature Communications (Nature) Austria, USA , 02 April 2024

Dermatology

Key words: Adaptive immunity, Gene regulation in immune cells, Interleukins, Mucosal immunology, Translational research

Organism: Human

Tissue: Skin

Pathological State: Atopic Dermatitis

619
Modified Goldner Trichrome for Non-decalcified Mineralized Tissue Plastinated and Embedded in Resin

C Panes, N Ponce, NE Ottone, I ValdiviaGandur, V Beltrán, B Vásquez

International Journal of Morphology (Chilean Society of Anatomy) Chile , 01 April 2024

Histology, Tissue Engineering

Key words: Trichrome staining; Plastic resins; Hard Tissue histology.

Organism: Rabbit, Dog

Tissue: Tooth, Bone

620
Gut microbiota-bile acid crosstalk and metabolic fatty liver in spotted seabass (Lateolabrax maculatus): The role of a cholesterol, taurine and glycine supplement

T Song, X Liang, H Wang, M Xue, J Wang

Animal Nutrition (Elsevier) China , 30 March 2024

Nutritional science

Key words: Cholesterol-taurine-glycine supplement, Plant-based diets, Fatty liver, Gut microbiota–bile acid crosstalk, Lipid metabolism

Organism: Fish

Tissue: Liver

Results 611 - 620 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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