Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 591 - 600 of 3421
591
Influence of Decompression on the Expression of Inflammatory and Tissue Repair Biomarkers in Large Periapical Lesions

C Chen, I Liao, K Chen, C Kuo

(American Association of Endodontist) China , 20 April 2024

Dentistry

Organism: Human

Tissue: Gum

Pathological State: Inflammation

592
Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization

W Wang, T Li, Y Cheng, F Li, S Qi, M Mao, J Wu, Q Liu, X Zhang, X Li, L Zhang, H Qi, L Yang, K Yang, Z He, S Ding, Z Qin, Y Yang, X Yang, C Luo, Y Guo, C Wang, X Liu, L Zhou, Y Liu, W Kong, J Miao, S Ye, M Luo, L An, L Wang, L Che, Q Niu, Q Ma, X Zhang, Z Zhang, R Hu, H Feng, YF Ping, XW Bian, Y Shi

Cancer Cell (Cell Press) China , 18 April 2024

Oncology, Immunology

Key words: glioma, glioblastoma, tumor-associated macrophages, hypoxia, necrosis, vasculature normalization, single-cell transcriptomics, adrenomedullin, spatial transcriptomics, dabrafenib

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

593
Efficacy and biomarker analysis of second‐line nab‐paclitaxel plus sintilimab in patients with advanced biliary tract cancer

X Li, N Zhou, Y Yang, Z Lu, H Gou

Cancer Science (Wiley) China , 18 April 2024

Oncology

Organism: Human

Tissue: Bile duct

Pathological State: Cancer

594
ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance

CJ Lee, H Lee, SR Kim, SB Nam, GE Lee, KE Yang, GJ Lee, SH Chun, HC Kang, JY Lee, HS Lee, SJ Cho, YY Cho

Cell Death & Disease (Nature) South Korea, USA , 17 April 2024

Oncology

Key words: Oncogenesis, Ubiquitylation

Organism: Human

Tissue: Prostate

Pathological State: Cancer

595
Spatiotemporal architecture of immune cells and cancer-associated fibroblasts in high-grade serous ovarian carcinoma

AM Xu, M Haro, AE Walts, Y Hu, J John, BY Karlan, A Merchant, S Orsulic

Science Advances (Science) USA , 17 April 2024

Oncology, Immunology

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

596
Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment

NK Horvat, S Chocarro, O Marques, TA Bauer, R Qiu, AJ Diaz-Jimenez, B Helm, Y Chen, S Sawall, R Sparla, L Su, U Klingmüller, M Barz, MW Hentze, R Sotillo, MU Muckenthaler

ACS Nano (ACS Publications) Germany, The Netherlands , 16 April 2024

Oncology

Key words: iron homeostasis, nanoparticle, polymeric miceclle, lung cancer, adjuvant therapy

Organism: Mouse

Pathological State: Cancer

Cell Line: Lewis lung carcinoma cells

597
In vivo SPECT imaging of Tc-99 m radiolabeled exosomes from human umbilical-cord derived mesenchymal stem cells in small animals

YH Chung, YP Ho, SS Farn, WC Tsai, ZX Li, TY Lin, CC Wenig

Biomedical Journal (Elsevier) Taiwan , 16 April 2024

Pharmacology

Key words: Tc-99, USMSC-Evs, SPECT, Biodistribution, Pharmacokinetic analyses

Organism: Human

Cell Line: UCMSC-EVs

598
Coronary Microvascular Dysfunction in Acute Cholestasis-Induced Liver Injury

S Billig, M Hein, C Kirchner, D Schumacher, MA Habigt, M Mechelinck, D Fuchs, U Klinge, A Theißen, C Beckers, C Bleilevens, R Kramann, M Uhlig

Biomedicines (MDPI) Germany, The Netherlands , 16 April 2024

Hepathology

Key words: acute cholestatic liver injury; cardiac function; liver–heart axis; rodent model; coronary microvascular dysfunction; myocardial contrast echocardiography; coronary flow velocity reserve

Organism: Mouse

Tissue: Liver

Pathological State: Acute Liver Injury

599
Versatile tissue‐injectable hydrogels capable of the extended hydrolytic release of bioactive protein therapeutics

ES Nealy, SJ Reed, SM Adelmund, BA Badeau, JA Shadish, EJ Girard, K Brasel, FJ Pakiam, AJ Mhyre, JP Price, S Sarkar, V Kalia, CA DeForest, JM Olson

Bioengineering & Translational Medicine (Wiley) USA , 15 April 2024

Biomaterials, Pharmacology

Key words: drug delivery, extended release, hydrogels, immuno-oncology, loco-regional, proteins, sortase

Organism: Mouse

Tissue: Brain

600
Th17 cells secrete TWEAK to trigger epithelial-mesenchymal transition and promote colorectal cancer liver metastasis

X Liu, X Wang, Q Yang, L Luo, Z Liu, X Ren, K Lei, S Li, Z Xie, G Zheng, Y Zhang, Y Hao, Q Zhou, Y Hou, F Fang, W Song, J Cui, J Ma, W Xie, S Shen, C Tang, S Peng, J Yu, M Kuang, X Song, F Wang, L Xu

Cancer Research (AACR) China , 15 April 2024

Oncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

Results 591 - 600 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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