Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 591 - 600 of 3476
591
Oxymatrine and Gut Microbiota Modulation: A Potential Therapeutic Strategy for Bone Cancer Pain Management

Z Liu, H Chen, X Ning, J Li, L Pan

The Journal of Pain (Elsevier) China , 04 June 2024

Pharmacology, Oncology

Key words: Bone Cancer Pain, Gut Microbiota, Clostridium butyricum, Nab, OMT, PPAR gamma

Organism: Mouse

Tissue: Brain

592
Predictive model based on multiple immunofluorescence quantitative analysis for pathological complete response to neoadjuvant immunochemotherapy in lung squamous cell carcinoma

M Xiao, L Tu, T Zhou, Y He, X Li, Q Zuo

Frontiers in Oncology (Frontiers Media S.A.) China , 03 June 2024

Oncology, Immunology

Key words: lung squamous cell carcinoma, neoadjuvant immunochemotherapy, pathological complete response, predictive model, multiple immunofluorescence quantitative analysis

Organism: Human

Tissue: Lung

Pathological State: Cancer

593
IL-6 inhibition prevents costimulation blockade-resistant allograft rejection in T cell-depleted recipients by promoting intragraft immune regulation in mice

M Muckenhuber, K Mengrelis, AM Weijler, R Steiner, V Kainz, M Buresch, H Regele, S Derdak, A Kubetz, T Wekerle

Nature Communications (Nature) Austria , 03 June 2024

Immunology

Key words: Allotransplantation, Translational immunology

Organism: Mouse

Tissue: Heart

Pathological State: Graft Rejection

594
Unravelling the role of the tumour microenvironment in follicular lymphoma progression through characterisation of the mutational, transcriptomic and spatial immune landscape

LA Pickard

(Queen Mary University of London) UK , 01 June 2024

Oncology

Organism: Human

Tissue: Blood

Pathological State: Cancer

595
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

B Do, P Hsu, S Vermeulen, Z Wang, T Hirz, K Abbott, N Aziz, J Replogle, S Bjelosevic, J Paolino, S Nelson, S Block, A Darnell, R Ferreira, H Zhang, J Milosevic, D Schmidt, C Chidley, I Harris, J Weissman, Y Pikman, K Stegmaier, S Cheloufi, X Su, D Sykes, M Vander Heiden

Developmental Cell (Cell Press) USA , 31 May 2024

Cell Biology, Genetics

Key words: replication, cancer, differentiation, epigenetics, cell state, replication stress, nucleotides, dependencies, metabolism, hematopoiesis, cell fate

Cell Line: primary human CD34+ HSPCs

596
Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma

D Gu, X Zhao, J Song, J Xiao, L Zhang, G Deng, D Li

Frontiers in Immunology (Frontiers) China , 31 May 2024

Oncology

Key words: cholangiocarcinoma, multiplex immunofluorescence, carcinogenesis, prognosis, IL-6/STAT3 pathway, tissue microarray

Organism: Human

Tissue: Bile duct

Pathological State: Cancer

597
A novel exosome-based multifunctional nanocomposite platform driven by photothermal-controlled release system for repair of skin injury

X Teng, T Liu, G Zhao, Y Liang, P Li, F Li, Q Li, J Fu, C Zhong, X Zou, L Li, L Qi

Journal of Controlled Release (Elsevier) China , 31 May 2024

Nanomedicine, Regenerative Medicine

Key words: Exosomes, Hydrogel, Ti3C2, Photothermal, Controlled release, Skin injury

Organism: Mouse

Tissue: Skin

Pathological State: skin injury

598
Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression

Z Liang, Z Tang, C Zhu, F Li, S Chen, X Han, R Zheng, X Hu, R Lin, Q Pei, C Yin, J Wang, C Tang, N Cao, J Zhao, R Wang, X Li, N Luo, Q Wen, J Yu, J Li, X Xia, X Zheng, X Wang, N Huang, Z Zhong, C Mo, P Chen, Y Wang, J Fan, Y Guo, H Zhong, J Liu, Z Peng, H Mao, G Shi, J Bonventre, W Chen, Y Zhou

Immunity (Cell Press) China, USA , 29 May 2024

Immunology, Nephrology

Key words: renal fibrosis, group 3 innate lymphoid cells, gut-kidney axis, programmed death receptor-1

Organism: Human

Tissue: Kidney

Pathological State: Renal fibrosis

599
Intestinal ILC3s Migrate to the Kidney and Promote Renal Fibrosis via PD-1-mediated Activation

Z Liang, Z Tang, C Zhu, F Li, S Chen, X Han, R Zheng, X Hu, R Lin, Q Pei, C Yin, J Wang, C Tang, N Cao, J Zhao, R Wang, X Li, N Luo, Q Wen, J Yu, J Li, X Xia, X Zheng, X Wang, N Huang, Z Zhong, C Mo, P Chen, Y Wang, J Fan, Y Guo, H Zhong, J Liu, Z Peng, H Mao, GP Shi, JV Bonventre, W Chen, Y Zhou

Immunity (Cell) China, USA , 29 May 2024

Nephrology

Key words: renal fibrosis, group 3 innate lymphoid cells, gut-kidney axis, programmed death receptor-1

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Fibrosis

600
Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis

G Tomić, C Sheridan, AY Refermat, MP Baggelaar, J Sipthorp, B Sudarshan, CA Ocasio, A Suárez-Bonnet, SL Priestnall, E Herbert, EW Tate

Cell Reports (Cell Press) UK, The Netherlands , 28 May 2024

Oncology

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

Results 591 - 600 of 3476

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