Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 571 - 580 of 3476
571
Concomitant NAFLD Facilitates Liver Metastases and PD-1-Refractory by Recruiting MDSCs via CXCL5/CXCR2 in Colorectal Cancer

Y Yang, Y Chen, Z Liu, Z Chang, Z Sun, L Zhao

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) China , 14 June 2024

Oncology, Hepathology

Key words: Nonalcoholic Fatty Liver Disease, Colorectal Cancer, Liver Metastasis, Myeloid-Derived Suppressor Cells, Immune-Checkpoint Inhibitors

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

572
Antibody nanoparticle conjugate–based targeted immunotherapy for non–small cell lung cancer

T Saha, M Fojtů, AV Nagar, L Thurakkal, BB Srinivasan, M Mukherjee, A Sibiyon, H Aggarwal, A Samuel, C Dash, HL Jang, S Sengupta

Science Advances (Science) USA , 14 June 2024

Oncology, Nanomedicine

Organism: Human

Tissue: Lung

Pathological State: Cancer

573
Noninvasive Transdermal Administration of mRNA Vaccines Encoding Multivalent Neoantigens Effectively Inhibits Melanoma Growth

Y Hou, Z Wang, Z Chen, L Shuai, Y Pei, B Sun, Y Jiang, H Wang

ACS Biomaterials Science and Engineering (ACS Publications) China , 13 June 2024

Pharmacology, Oncology

Key words: Anatomy, Cells,Genetics, Peptides and proteins, Tumors

Organism: Mouse

Tissue: Skin

Pathological State: Cancer

574
Impaired gut barrier integrity and reduced colonic expression of free fatty acid receptors in patients with Parkinson's disease

PH Liao, HY Tung, WS Lim, JSR Jang, H Li, CT Shun, HM Chiu, MS Wu, CH Lin

Neurological Sciences (Springer) Taiwan , 12 June 2024

Gastroenterology, Neuroscience

Key words: Free fatty acid receptor, Short-chain fatty acid, Leaky gut, Tight junction, Parkinson’s disease

Organism: Human

Tissue: Colon

Pathological State: Parkinson’s disease

575
A Lactobacillus Combination Ameliorates Lung Inflammation in an Elastase/LPS—induced Mouse Model of Chronic Obstructive Pulmonary Disease

HT Shen, YT Fang, WH Tsai, CH Chou, MS Huang, YT Yeh, JT Wu, CH Huang, BY Wang, WW Chang

Probiotics and Antimicrobial Proteins (Springer) Taiwan , 12 June 2024

Pulmonology, Microbiology

Key words: COPD, Lactobacillus, Gut microbiota, Gut-lung axis, Short chain fatty acids

Organism: Mouse

Tissue: Lung

Pathological State: Chronic Obstructive Pulmonary Disease

576
Bidirectional activation of stem-like programs between metastatic cancer and alveolar type 2 cells within the niche

FS Rodrigues, A Karoutas, S Ruhland, N Rabas, T Rizou, SD Blasio, RMM Ferreira, VL Bridgeman, R Goldstone, ML Sopena, JH Lee, L Ombrato, I Malanchi

Developmental Cell (Cell Press) UK, USA , 11 June 2024

Oncology, Stem Cell Research

Key words: Metastasis, metastatic niche, breast cancer, alveolar type 2 cells, multilineage state, Sox9, metastasis-initiating cells, lung stem cells, tissue reprogramming

577
AB0735 ALTERED GALECTIN EXPRESSION CORRELATE WITH TNF-MEDIATED INFLAMMATORY CARTILAGE DAMAGE

S Hayer, B Niederreiter, C Strauß, R Windhager, D Aletaha, S Toegel

Annals of the Rheumatic Diseases (BMJ Journals) Austria , 10 June 2024

Immunology, Osteology

Organism: Mouse

Tissue: Joint Tissue

Pathological State: Cancer

578
A fusion protein approach to integrate antiviral and anti-inflammatory activities for developing new therapeutics against influenza A virus infection

G Zhai, W Fu, S Yuan, P Sun, C Zhu, C Zhao, X Zhang, J Xu

Antiviral Research (Elsevier) China , 10 June 2024

Immunology

Key words: IFNα2-TFF2 fusion protein, H1N1 (PR8), Antiviral, Anti-inflammation, Mice protectivity

Organism: Mouse

Tissue: Lung

Pathological State: Influenza A virus infection

579
The macrophage polarization in allergic responses induced by tropomyosin of Macrobrachium nipponense in cell and murine models

Y Xie, X Hu, X Li, P Tong, Y Zhang, S Zheng, J Zheng, X Liu, H Chen

International Immunopharmacology (Elsevier) China, USA , 10 June 2024

Immunology, Allergy Research

Key words: Macrophage, Polarization, Allergic responses, Tropomyosin, Macrobrachium nipponense

Organism: Mouse

Tissue: Intestine

Pathological State: Macrobrachium nipponense Infection

580
Characteristics of Retinal Vascular Degeneration and the Expression of Vessel-Related Claudin Proteins in Retinal Degeneration Mouse

A Wang, J Zhou, Y Hong, Y Cui, Y Wang, J Pan, Y Wu, Y Luo

Ophthalmic Research (Karger) China , 10 June 2024

Ophthalmology

Key words: angiogenesis, vascular degeneration, claudin, retinal degeneration, retinal ganglion cell

Organism: Mouse

Tissue: Eye

Pathological State: Retinal Vascular Degeneration

Results 571 - 580 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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