Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 561 - 570 of 3421
561
Prohibitin 2 deficiency in photoreceptors leads to progressive Retinal Degeneration and facilitated Müller glia engulfing microglia debris

H Zuo, W Han, K Wu, H Yang, H Song, Z Zhang, Y Lai, Z Pan, W Li, L Zhao

Experimental Eye Research (Elsevier) China , 17 May 2024

Ophthalmology

Key words: Microglia; Müller glia; Phagocytosis; Phb2; Photoreceptor; Progressive retinal degeneration.

Organism: Mouse

Tissue: Eye

Pathological State: Retinal Degeneration

562
Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network

S Amemori, AM Graybiel, K Amemori

Nature Communications (Nature) Japan, USA , 17 May 2024

Neuroscience

Key words: Cognitive control, Limbic system, Motivation, Prefrontal cortex

Organism: Monkey

Tissue: Brain

563
Prenatal 1‐Nitropyrene Exposure Causes Autism‐Like Behavior Partially by Altering DNA Hydroxymethylation in Developing Brain

T Zhao, CQ Huang, YH Zhang, YY Zhu, XX Chen, T Wang, J Shao, XH Meng, Y Huang, H Wang, HL Wang, B Wang, DX Xu

Advanced Science (Wiley) China , 16 May 2024

Neuroscience

Organism: Mouse

Tissue: Brain

564
Picornavirus VP3 protein induces autophagy through the TP53-BAD-BAX axis to promote viral replication

R Mao, Z Zhu, F Yang, D Sun, X Zhou, W Cao, X Qin, W Dang, H Liu, H Tian, K Zhang, Q Wu, X Liu, H Zheng

Autophagy (Taylor & Francis) China , 16 May 2024

Virology, Molecular Biology

Key words: Autophagy, picornavirus, replication, TP53-BAD-BAX axis, VP3

Organism: Other Rodent

Tissue: Skin

Pathological State: Picornavirus Infection

565
ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection

LE Bazzone, J Zhu, M King, G Liu, Z Guo, CR MacKay, PP Kyawe, N Qaisar, JQ Rojas-Quintero, CA Owen, AL Brass, W McDougall, CE Baer, T Cashman, CM Trivedi, MU Gack, RW Finberg, EA Kurt-Jones

Nature Communications (Nature) USA , 16 May 2024

Virology

Key words: Innate immunity, Viral host response, Viral infection

Organism: Mouse

Tissue: Lung

Pathological State: Viral Infection

566
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways

Y Yan, S Bai, H Han, J Dai, L Niu, H Wang, Q Dong, H Yin, G Yuan, Y Pan

Cell Communication and Signaling (Springer) China , 15 May 2024

Oncology

Key words: Glioma, Glioblastoma, Microglia, Trem2 protein, Stat1 protein, Microglial polarization

Organism: Human

Tissue: Brain

Pathological State: Cancer

567
Building momentum through networks: Bioimaging across the Americas

MD Niz, RE García, CT Ramirez, Y Pakowski, Y Abonza, N Bialy, VL Orr, A Olivera, V Abonza, K Alleva, S Allodi, MF Almeida, ARB Cuevas, F Bonnet, AB Solorio, TL Chew, G Chiabrando, B Cimini, AB Cleret-Buhot, GC Jiménez, L Daza, VD Sá, ND Val, DLÁ Delgado-Álvarez, K Eliceiri, R Fiolka, H Grecco, D Hanein, PH Herrera, P Hockberger, HO Hernandez, YH Guadarrama, M Itano, CA Jacobs, LFG Jiménez-García, VJ Sabinina, A Kamaid, A Keppler, A Kumar, J Lacoste, A Lovy, KP Luby-Phelps, AJ Mahadevan-Jansen, L Malacrida, SB Mehta, C Miller, K Miranda, JA Moore, A North, P O'Toole, MO Urbano, LI Pietrasanta, RV Portugal, AH Rossi, JS Contreras, CDC Strambio-De-Castilla, G Soldevila, B Vale, D Vazquez, C Wood, CM Brown, A Guerrero

Journal of Microscopy (Wiley) USA, Mexico, Uruguay, Argentina, Canada, Colombia, South Africa, Brazil, Chile, Germany, UK , 15 May 2024

Imaging

Key words: bioimaging networks, BioImaging North America, community-building, imaging scientists, Latin America Bioimaging

568
Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

C Hromada, P Heimel, M Kerbl, L Gál, S Nürnberger, B Schaedl, J Ferguson, N Swiadek, X Monforte, JC Heinzel, A Nógrádi, AH Teuschl-Woller, D Hercher

Neural Regeneration Research (Wolters Kluwer) Austria, Hungary, Germany , 13 May 2024

Neuroscience

Organism: Mouse

Tissue: Nerve

Pathological State: Sciatic Nerve Defect

569
Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function

HW Lee, SJ Chen, KJ Tsai, KS Hsu, YF Chen, CH Chang, HH Lin, WY Hsueh, HP Hsieh, YF Lee, HC Chiang, JY Chang

Journal of biomedical science (Springer) Taiwan , 09 May 2024

Neuroscience, Molecular Biology

Key words: Cathepsin S, Cognitive function, OLF-1, Brain-derived neurotrophic factor

Organism: Mouse

Tissue: Brain

570
Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury

J Nehme, L Mesilmany, M VarelaEirin, S Brandenburg, A Altulea, Y Lin, M Gaya da Costa, M Seelen, J Hillebrands, H van Goor, R Saab, H Akl, N Prevarskaya, V Farfariello, M Demaria

Nature Aging (Nature) The Netherlands, Lebanon, France, USA , 09 May 2024

Aging, Regenerative Medicine

Key words: Aging, Senescence

Results 561 - 570 of 3421

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