Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 551 - 560 of 3476
551
Suppressing SENP1 inhibits esophageal squamous carcinoma cell growth via SIRT6 SUMOylation

J Gu, S Zhang, D Lin, W Wang, J Cheng, Q Zheng, H Wang, L Tan

Cellular Oncology (Springer) China , 02 July 2024

Oncology

Key words: Esophageal squamous cell carcinoma, SENP1, Cell cycle, SUMOylation, SIRT6

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

552
Recruitment of neutrophils in glomeruli in early mouse sepsis is associated with E-selectin expression and activation of endothelial NF-κB and MAPK pathways

Z Wang, EZ Dayang, PJ Zwiers, ML Hernandez Garcia, M Luxen, M van Meurs, JAM Kamps, J Moser, G Molema

Journal of Leukocyte Biology (Oxford Academic) The Netherlands , 02 July 2024

Immunology, Nephrology

Key words: polymicrobial abdominal sepsis, kidney, leukocytes, endothelial cells, endothelial adhesion molecules, NF-κB p65, MAPK c-Jun

Organism: Rat

Tissue: Kidney

553
Effect of Early Inhibition of Toll-Like Receptor 4 on Hippocampal Plasticity in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage

Q Li, Z Ouyang, Y Zhang, Z Li, X Zhu, Z Tang

Molecular Neurobiology (Springer) China , 02 July 2024

Neuroscience

Key words: Hypoxic-ischemia, Brain injury, Hippocampus plasticity, TLR4, Rat

Organism: Rat

Tissue: Brain

Pathological State: Hypoxic-Ischemic Brain Damage

554
Recruitment of neutrophils in glomeruli in early mouse sepsis is associated with E-selectin expression and activation of endothelial nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinase pathways

Z Wang, EZ Dayang, PJ Zwiers, MLH Garcia, M Luxen, MV Meurs, JAAM Kamps, J Moser, G Molema

Journal of Leukocyte Biology (Oxford Academic) The Netherlands, Malaysia, Germany , 02 July 2024

Immunology

Organism: Mouse

Tissue: Kidney

Pathological State: Inflammation

555
Dihydromyricetin ameliorates experimental ulcerative colitis by inhibiting neutrophil extracellular traps formation via the HIF-1α/VEGFA signaling pathway

X Ma, M Li, X Wang, H Xu, L Jiang, F Wu, L Wei, G Qi, D Zhang

International Immunopharmacology (Elsevier) China , 01 July 2024

Gastroenterology, Immunology

Key words: Dihydromyricetin, Ulcerative colitis, Neutrophil extracellular traps, HIF-1α, VEGFA

Organism: Mouse

Tissue: Intestine

Pathological State: Ulcerative colitis

556
Comparative Analysis of Osteointegration in Hydroxyapatite and Hydroxyapatite-Titanium Implants: An In Vivo Rabbit Model Study

RM Văruț, LT Rotaru, FN Truicu, CE Singer, I Iulian-Nicolae, AIS Popescu, C Popescu, C Teisanu, G Sima, OE Nicolaescu

Journal of Functional Biomaterials (MDPI) Romania , 29 June 2024

Osteology

Key words: bioceramic; two-steps sintering; osteointegration

Organism: Rabbit

Tissue: Bone

Pathological State: Osteolysis

557
Growth, Antioxidant Capacity, and Liver Health in Largemouth Bass (Micropterus salmoides) Fed Multi-Strain Yeast-Based Paraprobiotic: A Lab-to-Pilot Scale Evaluation

J Wang, X Xie, Y Liu, J Liu, X Liang, H Wang, G Li, M Xue

Antioxidants (MDPI) China , 28 June 2024

Nutritional science

Key words: largemouth bass; multi-strain yeast-based paraprobiotics; pilot-scale experiment; antioxidant capacity; immune responses; liver health

Organism: Fish

Tissue: Liver

558
HMGB1-Mediated Cell Death—A Crucial Element in Post-Hepatectomy Liver Failure

L Brunnthaler, TG Hammond, D Pereyra, J Santol, J Probst, V Laferl, U Resch, M Aiad, AS Janoschek, T Gruenberger, H Hackl, P Starlinger, A Assinger

International Journal of Molecular Science (MDPI) Austria, Switzerland , 28 June 2024

Hepathology

Key words: partial hepatectomy; post hepatectomy liver failure; HMGB1; caspase-cleaved keratin-18

Organism: Mouse

Tissue: Liver

Pathological State: Post Hepatectomy Liver Failure

559
Rosmarinic acid Liposomes Suppress Ferroptosis in Ischemic Brain via Inhibition of TfR1 in BMECs

C Jia, Y Gou, Y Gao, X Pei, X Jin, B Li, Z Zhang, Y He, ES Ji, Y Zhao

Phytomedicine (Elsevier) China , 28 June 2024

Neuroscience

Key words: Ischemic stroke, Transferrin receptor protein 1, Ferroptosis, Rosmarinic acid, Nanoliposomes

Organism: Mouse

Tissue: Brain

560
First in vitro cell co-culture experiments using laser-induced high-energy electron FLASH irradiation for the development of anti-cancer therapeutic strategies

S Orobeti, LE Sima, I Porosnicu, C Diplasu, G Giubega, G Cojocaru, R Ungureanu, C Dobrea, M Serbanescu, A Mihalcea, E Stancu, CE Staicu, F Jipa, A Bran, E Axente, S Sandel, M Zamfirescu, I Tiseanu, F Sima

Scientific Reports (Nature) Romania , 27 June 2024

Oncology, Pharmacology

Key words: Laser-produced plasmas, Radiotherapy, wide-field fluorescence mircoscopy

Organism: Human

Pathological State: Cancer

Cell Line: A375

Results 551 - 560 of 3476

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