Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 551 - 560 of 3421
551
PAK2 promotes proliferation, migration, and invasion of lung squamous cell carcinoma through LIMK1/cofilin signaling pathway

C Wang, J Wang, R Xu, X Huang, Q Li, C Zhang, B Yuan

The Journal of Biomedical Research (jbr-pub.org.cn) China , 27 May 2024

Oncology, Molecular Biology

Key words: PAK2, LUSC, LIMK1, cofilin

Organism: Human

Tissue: Lung

Pathological State: Cancer

552
Spatial transcriptomic brain imaging reveals the effects of immunomodulation therapy on specific regional brain cells in a mouse dementia model

EJ Lee, M Suh, H Choi, Y Choi, DW Hwang, S Bae, DS Lee

BMC genomics (Springer) South Korea , 25 May 2024

Neuroscience, Immunology

Key words: Spatial transcriptomics, Brain imaging, Cell type decomposition, Cell state annotation, Major brain cells, Rare immune cells, Immunomodulatory therapy

Organism: Mouse

Tissue: Brain

Pathological State: Dementia

553
Determining the optimal distal resection margin in rectal cancer patients by imaging of large pathological sections: An experimental study

S Lin, J Wei, H Lai, Y Zhu, H Gong, C Wei, B Wei, Y Luo, Y Liu, X Mo, H Zuo, Y Lin

Medicine (Wolters Kluwer) China , 24 May 2024

Oncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

554
Triptolide exposure triggers testicular vacuolization injury by disrupting the Sertoli cell junction and cytoskeletal organization via the AKT/mTOR signaling pathway

X Yang, L He, X Li, L Wang, T Bu, D Yun, X Lu, S Gao, Q Huang, J Li, B Zheng, J Yu, F Sun

Ecotoxicology and Environmental Safety (Elsevier) China , 23 May 2024

Reproductive Medicine

Key words: , esticular vacuolization injury, BTB integrity, Cytoskeleton, AKT/mTOR signaling

Organism: Mouse

Tissue: Testis

Pathological State: Testicular Vacuolization Injury

555
Neuroprotection effects of kynurenic acid-loaded micelles for the Parkinson's disease models

CM Chen, CY Huang, CH Lai, YC Chen, YT Chen, YT Hwang, CY Lin

Journal of Liposome Research (Taylor &Francis) Taiwan , 23 May 2024

Nanomedicine, Neuroscience

Key words: Kynurenic acid, kynurenic acid-loaded micelles, nanoparticles, neuroprotection, Parkinson’s disease

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson’s disease

556
Label Free Assessment of Key Biological Autofluorophores: Material Characteristics and Opportunities for Clinical Applications

JM Campbell, M Gosnell, A Agha, S Handley, A Knab, AG Anwer, A Bhargava, EM Goldys

Advanced Materials (Wiley) Australia , 22 May 2024

Imaging

Organism: Human

Tissue: Nerve

Pathological State: Amyotrophic Lateral Sclerosis

557
腦源性神經生長因子 (BDNF) 在腦內出血後促進神經生成之探討

TC Lin

National Taiwan University (National Taiwan University) Taiwan , 22 May 2024

Neuroscience

Organism: Rat

Tissue: Brain

Pathological State: Intracerebral Hemorrage

558
Multiomics integration reveals NETosis heterogeneity and TLR2 as a prognostic biomarker in pancreatic cancer

Y Fu, J Tao, Y Gu, Y Liu, J Qiu, D Su, R Wang,W Luo, T Liu, F Zhang, T Zhang, Y Zhao

NPJ Precision Oncology (Nature) China, UK , 20 May 2024

Oncology

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

559
TCL1A-expressing B cells are critical for tertiary lymphoid structure formation and the prognosis of oral squamous cell carcinoma

W Xie, J Lu, Y Chen, X Wang, H Lu, Q Li, N Jin, J He, L Ou, J Ni, Y Shen, L Shao

Journal of Translational Medicine (Springer) China , 19 May 2024

Oncology

Key words: B cells, Tertiary lymphoid structures, Oral squamous cell carcinoma, TCL1A

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

560
Insights into the effects of chronic combined chromium-nickel exposure on colon damage in mice through transcriptomic analysis and in vitro gastrointestinal digestion assay

S Zheng, Z Wang, X Cao, L Wang, X Gao, Y Shen, J Du, P Liu, Y Zhuang, X Guo

Ecotoxicology and Environmental Safety (Elsevier) China , 17 May 2024

Gastroenterology

Key words: Goblet cell; In vitro gastrointestinal digestion; Intestinal inflammation; RNA-seq; Tight junction.

Organism: Mouse

Tissue: Colon

Pathological State: Inflammation

Results 551 - 560 of 3421

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