Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 531 - 540 of 3421
531
OsNLP3 enhances grain weight and reduces grain chalkiness in rice

LQ Sun, Y Bai, J Wu, SJ Fan, SY Chen, ZY Zhang, JQ Xia, SM Wang, YP Wang, P Qin, SG Li, P Xu, Z Zhao, CB Xiang, ZS Zhang

Plant Communications (Cell Press) China , 08 June 2024

Agricultural Science, Genetics

Key words: OsNLP3, OsCEP6.1, OsNF-YA8, grain weight, grain chalkiness, rice, Oryza sativa L.

Organism: Plant

532
The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants

Y Lu, Y Sun, J Zhang, M Kong, Z Zhao, B Sun, Y Wang, Y Jiang, S Chen, C Wang, Y Tong, L Wen, M Huang, F Wu, L Zhang

Cancer Letters (Elsevier) China , 06 June 2024

Oncology, Immunology

Key words: USP2a, B7–H4, EGFR MT, Deubiquitination, Tumor immunosuppression

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

533
Integrating bulk and single-cell sequencing reveals metastasis-associated CAFs in head and neck squamous cell carcinoma

Y Yao, G Tian, J Zhang, S Zhang, X Liu, J Hou

Life Sciences (Elsevier) China , 06 June 2024

Oncology

Key words: HNSCC, Cancer-associated fibroblasts, Metastasis, TIMP1

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

534
Celastrol reduces lung inflammation induced by multiwalled carbon nanotubes in mice via NF-κb-signaling pathway

TL Qing, XY Jiang, JF Li, Q Shen, XY Zhao, LJ Ren, XY Dai, JQZ Zhang, WJ Shi, XF Zhang, B Zhang, L Yan, JK Chen, JB Zhu

Inhalation Toxicology (Taylor &Francis) China , 05 June 2024

Immunology, Nanomedicine

Key words: Celastrol, multiwalled carbon nanotubes, inflammation, NF-κB-signaling pathway

Organism: Mouse

Tissue: Lung

535
Extrusion of Neutrophil Extracellular Traps (NETs) Negatively Impacts Canine Sperm Functions: Implications in Reproductive Failure

M León, C Moya, RC Rivera-Concha, F Pezo, P Uribe, M Schulz, R Sánchez, A Taubert, C Hermosilla, F Zambrano

International Journal of Molecular Science (MDPI) Chile, Germany , 05 June 2024

Reproductive Medicine

Key words: canine; spermatozoon; PMNs; neutrophil extracellular traps (NETs); sperm functionality

Organism: Dog

Pathological State: Inflammation

Cell Line: Sperm

536
Randomized Phase II Study Evaluating the Addition of Pembrolizumab to Radium-223 in Metastatic Castration-resistant Prostate Cancer

AD Choudhury, L Kwak, A Cheung, KM Allaire, J Marquez, DD Yang, A Tripathi, JM Kilar, M Flynn, B Maynard, R Reichel, AF Pace, BK Chen, EMV Allen, K Kilbridge, XX Wei, BA McGregor, MM Pomerantz, RS Bhatt, CJ Sweeney, GJ Bubley, HA Jacene, ME Taplin, FW Huang, LC Harshman, L Fong

Cancer Immunology Research (AACR) USA, Australia , 04 June 2024

Oncology

Organism: Human

Tissue: Prostate

Pathological State: Cancer

537
Pyroptosis and mitochondrial function participated in miR-654-3p-protected against myocardial infarction

C Wu, XC Zhang, LR Chen, HZ Huang, WY Wu, Y Wang, G Li

Cell Death & Disease (Nature) China , 04 June 2024

Cardiology

Key words: Myocardial infarction, Translational research

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Infarction

538
PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation

VC Ribeiro, LC Russo, NC Hoch

The EMBO Journal (EMBOpress) Brazil , 04 June 2024

Virology

Organism: Human

Pathological State: Viral Infection

Cell Line: CRM-CCL-185

539
Oxymatrine and Gut Microbiota Modulation: A Potential Therapeutic Strategy for Bone Cancer Pain Management

Z Liu, H Chen, X Ning, J Li, L Pan

The Journal of Pain (Elsevier) China , 04 June 2024

Pharmacology, Oncology

Key words: Bone Cancer Pain, Gut Microbiota, Clostridium butyricum, Nab, OMT, PPAR gamma

Organism: Mouse

Tissue: Brain

540
Predictive model based on multiple immunofluorescence quantitative analysis for pathological complete response to neoadjuvant immunochemotherapy in lung squamous cell carcinoma

M Xiao, L Tu, T Zhou, Y He, X Li, Q Zuo

Frontiers in Oncology (Frontiers Media S.A.) China , 03 June 2024

Oncology, Immunology

Key words: lung squamous cell carcinoma, neoadjuvant immunochemotherapy, pathological complete response, predictive model, multiple immunofluorescence quantitative analysis

Organism: Human

Tissue: Lung

Pathological State: Cancer

Results 531 - 540 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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