Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 531 - 540 of 3476
531
Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19

TZ Wen, TR Li, XY Chen, HY Chen, S Wang, WJ Fu, SQ Xiao, J Luo, R Tang, JL Ji, JF Huang, ZC He, T Luo, HL Zhao, C Chen, JY Miao, Q Niu, Y Wang, XW Bian, XH Yao

Metabolism (Elsevier) China , 23 July 2024

Endocrinology, Virology

Key words: Adrenal gland, COVID-19, Steroidogenesis, Proteomics, Histopathology, Autopsy

Organism: Human

Tissue: Adrenal Gland

Pathological State: SARS-CoV-2 Infection

532
Implementation of Digital Pathology and Artificial Intelligence in Routine Pathology Practice

DY Zhang, A Venkat, H Khasawneh, R Sali, V Zhang, Z Pei

Laboratory Investigation (Elsevier) USA , 23 July 2024

Imaging

Key words: artificial intelligence, artificial intelligence diagnostics, artificial intelligence pathology, artificial intelligence prognostic, artificial intelligence treatment, digital pathology, Food and Drug Administration, approval, whole slide imaging

533
Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm

YK Hong, TL Cheng, CK Hsu, FT Lee, BI Chang, KC Wang, LY Chang, HL Wu, CH Lai

International Journal of Biological Sciences (Ivyspring) Taiwan, USA , 20 July 2024

Cardiology, Molecular Biology

Key words: Tumor endothelial marker 1 (TEM1, CD248, endosialin), abdominal aortic aneurysm (AAA), vascular smooth muscle cell, fibroblast, phenotypic change, collagen synthesis

Organism: Human

Tissue: Blood Vessels

Pathological State: Abdominal aortic aneurysm

534
The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer

Y Hou, B Lin, T Xu, J Jiang, S Luo, W Chen,X Chen, Y Wang, G Liao, J Wang, J Zhang, X Li, X Xiang, Y Xie, J Wang, S Peng, W Lv, Y Liu, H Xiao

Nature Communications (Nature) China , 19 July 2024

Oncology

Key words: Cancer microenvironment, Thyroid cancer, Tumour immunology

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

535
GPR34 senses demyelination to promote neuroinflammation and pathologies

B Lin, Y Zhou, Z Huang, M Ma, M Qi, Z Jiang, G Li, Y Xu, J Yan, D Wang, X Wang, W Jiang, R Zhou

Cellular & Molecular Immunology (Nature) China , 19 July 2024

Neuroscience, Immunology

Key words: Neuroinflammation, GPCRs, Microglia, Inflammation, Neuroimmunology

536
Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells.

MT Latancia, G da Silva Leandro, AU Bastos, NC Moreno, ABA Ariwoola, DJ Martins, NW Ashton, VC Ribeiro, NC Hoch, CRR Rocha, R Woodgate, CFM Menck

DNA repair (Elsevier) Brazil , 18 July 2024

Oncology

Key words: Glioma, Temozolomide, Translesion synthesis, Cancer, Chemotherapy resistance, DNA polymerase

Cell Line: U251-MG glioblastoma cells

537
Boron Neutron Capture Therapy‐Derived Extracellular Vesicles via DNA Accumulation Boost Antitumor Dendritic Cell Vaccine Efficacy

L Lv, J Zhang, Y Wang, H Liang, Q Liu, F Hu, H Li, W Su, J Zhang, R Chen, Z Chen, Z Wang, J Li, R Yan, M Yang, YN Chang, J Li, T Liang, G Xing, K Chen

Advanced Science (Wiley) China , 17 July 2024

Oncology, Immunology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

538
NME4 suppresses NFκB2‐CCL5 axis, restricting CD8+ T cell tumour infiltration in oesophageal squamous cell carcinoma

S Zheng, S He, Y Liang, Q Liu, T Liu, Y Tan, T Peng, C Huang, H Gao, X Lu

Immunology (Wiley) China , 17 July 2024

Oncology, Immunology

Key words: CCL5, CD8T, NFκB2, NME4, oesophageal squamous cell carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

539
Eupalinolide B suppresses pancreatic cancer by ROS generation and potential cuproptosis

Q Huang, J Yang, J Zhang, L Yao, B Jiang, S Du, F Li, Q Peng, L Qin, Y Wang, L Qi

iScience (Cell Press) China , 13 July 2024

Oncology

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

540
3D hUC-MSC spheroids exhibit superior resistance to autophagy and apoptosis of granulosa cells in POF rat model

W Dai, H Yang, B Xu, T He, L Liu, Z Zhang, L Ding, X Pei, X Fu

Reproduction (Society for Reproduction and Fertility) China , 13 July 2024

Reproductive Medicine

Organism: Rat

Tissue: Ovaries

Pathological State: Premature ovarian failure

Results 531 - 540 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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