Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 511 - 520 of 3421
511
AIM2 enhances Candida albicans infection through promoting macrophage apoptosis via AKT signaling

Q Jiang, Y Chen, S Zheng, L Sui, D Yu, F Qing, W He, Q Xiao, T Guo, L Xu, Z Liu, Z Liu

Cellular and Molecular Life Sciences (Springer) China , 25 June 2024

Immunology

Key words: AIM2, Candida albicans, Macrophage, Apoptosis, AKT

Organism: Mouse

Tissue: Kidney

Pathological State: Fungal Infection

512
FOXO1 induced fatty acid oxidation in hepatic cells by targeting ALDH1L2

J Cheng, S Yang, D Shou, J Chen, Y Li, C Huang, H Chen, Y Zhou

Journal of Gastroenterology and Hepatology (Wiley) China , 25 June 2024

Metabolism, Hepathology

Key words: ALDH1L2, fatty acid oxidation, FOXO1, NAFLD

Organism: Mouse

Tissue: Liver

513
Creation of a biological sensorimotor interface for bionic reconstruction

C Festin, J Ortmayr, U Maierhofer, V Tereshenko, R Blumer, M Schmoll, GR Carrero-Rojas, M Luft, G Laengle, D Farina, KD Bergmeister, OC Aszmann

Nature Communications (Nature) Austria, UK, USA , 24 June 2024

Neuroscience

Key words: Peripheral nervous system, Regeneration and repair in the nervous system, Translational research

Organism: Rat

Tissue: Nerve

514
Magnolol's Therapeutic Efficacy and Immunomodulatory Effects in Oral Squamous Cell Carcinoma

CF Tseng, HM Chen, TL Liao, FT Hsu, CJ Yeh, WT Chen, SH Kok

in vivo (IIAR Journals) Taiwan , 20 June 2024

Oncology

Key words: Magnolol, oral squamous cell carcinoma, apoptosis, CD8 T cells, immunosuppressive

Organism: Mouse

Tissue: Heart, Kidney, Liver, Intestine

Pathological State: Cancer

515
Adoptive Cell Therapy in Mice Sensitized to a Grass Pollen Allergen

AM Weijler, L Prickler, V Kainz, E Bergmann, B Bohle, H Regele, R Valenta, B Linhart, T Wekerle

Antibodies (MDPI) Austria, Russia , 18 June 2024

Immunology

Key words: cell therapy; allergy; Phl p 5; tolerance; mouse model

Organism: Rat

Tissue: Skin

516
Vimentin, inversely correlating with infiltration of CD8+ T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma

Y Liang, S He, Q Liu, T Liu, Y Tan, T Peng, C Huang, X Lu, S Zheng

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (Elsevier) China , 18 June 2024

Oncology

Key words: Vimentin, CD8T, PD-L1, PD-L2, Translocation, ESCC

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

517
Cytotoxic Oxidative Stress Effects of Neutrophil Extracellular Traps' Components on Cattle Spermatozoa

R Rivera-Concha, M León, A Prado-Sanhueza, R Sánchez, A Taubert, C Hermosilla, P Uribe, F Zambrano

Antioxidants (MDPI) Chile, Germany , 17 June 2024

Reproductive Medicine

Key words: cattle; neutrophil extracellular traps; spermatozoa; oxidative stress

Organism: Cow

Tissue: Sperm

Pathological State: Oxidative Stress

518
High dietary Fructose Drives Metabolic Dysfunction-Associated Steatotic Liver Disease via Activating ubiquitin-specific peptidase 2/11β-hydroxysteroid dehydrogenase type 1 Pathway in Mice

C Li, M Li, W Sheng, W Zhou, Z Zhang, G Ji, L Zhang

International Journal of Biological Sciences (IJBS) China , 17 June 2024

Nutritional science

Key words: dietary fructose, MASLD, hepatic steatosis, inflammation, USP2

Organism: Mouse

Tissue: Liver

Pathological State: Metabolic dysfunction-associated steatotic liver disease

519
Concomitant NAFLD Facilitates Liver Metastases and PD-1-Refractory by Recruiting MDSCs via CXCL5/CXCR2 in Colorectal Cancer

Y Yang, Y Chen, Z Liu, Z Chang, Z Sun, L Zhao

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) China , 14 June 2024

Oncology, Hepathology

Key words: Nonalcoholic Fatty Liver Disease, Colorectal Cancer, Liver Metastasis, Myeloid-Derived Suppressor Cells, Immune-Checkpoint Inhibitors

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

520
Antibody nanoparticle conjugate–based targeted immunotherapy for non–small cell lung cancer

T Saha, M Fojtů, AV Nagar, L Thurakkal, BB Srinivasan, M Mukherjee, A Sibiyon, H Aggarwal, A Samuel, C Dash, HL Jang, S Sengupta

Science Advances (Science) USA , 14 June 2024

Oncology, Nanomedicine

Organism: Human

Tissue: Lung

Pathological State: Cancer

Results 511 - 520 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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