Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 501 - 510 of 3476
501
Single-cell RNA sequencing highlights the immunosuppression of IDO1+ macrophages in the malignant transformation of oral leukoplakia

Y Zhang, JZS Zhao, Y Xu, Y Huang, S Liu, P Su, C Wang, Y Li, H Li, P Yang,✉, C Yang

Theranostics (Ivyspring) China , 12 August 2024

Oncology

Key words: Oral squamous cell carcinoma, Oral leukoplakia, immunosuppressive microenvironment, macrophage, indoleamine 2, 3-dioxygenase 1

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

502
Urolithin A attenuates hexavalent chromium-induced small intestinal injury by modulating PP2A/Hippo/YAP1 pathway

P Guo, R Yang, S Zhong, Y Ding, J Wu, Z Wang, H Wang, J Zhang, N Tu, H Zhou, S Chen, Q Wang, D Li, W Chen, L Chen

Journal of Biological Chemistry (Elsevier) China, USA , 10 August 2024

Biochemistry

Key words: hexavalent chromium, intestinal toxicity, protein phosphatase 2A, Hippo/YAP1 pathway, urolithin A

Organism: Mouse

Tissue: Intestine

Pathological State: Intestine Injury

503
miR-1915-3p regulates megakaryocytic and erythroid differentiation by targeting SOCS4

X Yuan, P Liu, L Xu, L Liang, Q Dong, T Fan, W Yue, M Qu, X Pei, X Xie

Thrombosis Journal (Springer) China , 09 August 2024

Hematology

Key words: Megakaryocytic and erythroid differentiation, miR-1915-3p, SOCS4

Organism: Mouse

Tissue: Bone Marrow

Pathological State: Acute Liver Injury

504
In Vitro Effect of Epigallocatechin Gallate on Heme Synthesis Pathway and Protoporphyrin IX Production

D León, ME Reyes, H Weber, Á Gutiérrez, C Tapia, R Silva, T Viscarra, K Buchegger, C Ili, P Brebi

International Journal of Molecular Science (MDPI) Chile , 09 August 2024

Pharmacology

Key words: squamous skin cancer; photodynamic therapy; resistance; methyl aminolevulinate; ferrochelatase; clonogenic capability; porphobilinogen deaminase

Organism: Human

Pathological State: Cancer

Cell Line: A-431

505
CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis

KC Cheung, J Ma, L Wang, X Chen, S Fanti, M Li, LR Azevado, F Gosselet, H Shen, X Zheng, A Lu, W Jia

Pharmacological Research (Elsevier) China, France, UK , 08 August 2024

Osteology

Key words: Endothelium, Rheumatoid arthritis, Inflammation, Autophagy, CD31, Glycosis and oxidative phosphorylation

Organism: Mouse

Tissue: Joint Tissue

Pathological State: Arthritis

506
BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice With Loss of the Polarity Protein Par3

MA Shields, AE Metropulos, C Spaulding, KA Alzahrani, T Hirose, S Ohno, TND Pham, HG Munshi

Cellular and Molecular Gastroenterology and Hepatology (AGA) USA , 08 August 2024

Neuroscience, Gastroenterology

Key words: Par3, Inflammation, ADM, Primary Cilia, BET Inhibitors

Organism: Human

Tissue: Pancreas

Pathological State: Pancreatitis

507
Nuclear factor of activated T-cells 5 is indispensable for a balanced adaptive transcriptional response of lung endothelial cells to hypoxia

H Laban, S Siegmund, K Schlereth, FA Trogisch, A Ablieh, L Brandenburg, A Weigert, CDL Torre, C Mogler, M Hecker, WM Kuebler, T Korff

Cardiovascular Research (Oxford Academic) Germany , 06 August 2024

Molecular Biology

Key words: NFAT5, Hypoxia, Endothelial cells, Pulmonary hypertension, Transcriptome

508
Unlocking the potential of HHLA2: identifying functional immune infiltrating cells in the tumor microenvironment and predicting clinical outcomes in laryngeal squamous cell carcinoma

W Li, J You, H Xue, Y Liu, J Chen, X Zheng, L Chen, C Wu

Cancer Immunology, Immunotherapy (Springer) China , 06 August 2024

Oncology, Immunology

Key words: Laryngeal squamous cell carcinoma, HHLA2, Immune infiltrating cell, Prognosis

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

509
A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model

JA Lewis, B Nemke, Y Lu, NA Sather, MT McClendon, M Mullen, SC Yuan, SK Ravuri, JA Bleedorn, MJ Philippon, J Huard, MD Markel, SI Stupp

Proceedings of the National Academy of Sciences of the United States of America (pnas.org) USA , 06 August 2024

Tissue Engineering

Key words: cartilage regeneration, supramolecular biomaterials, self-assembly, peptide amphiphiles

Organism: Sheep

Tissue: Connective Tissue

510
Diagnostic and prognostic value of CD44v9 and TIM3 expression in CK‑ and CK+ regions in gastric cancer tissues

X Wang, L Lu, R Yang, Z Wang, Q Li, J Li, Y Liu

Oncology Letters (Spandidos Publications) China , 06 August 2024

Oncology

Organism: Human

Tissue: Stomach

Pathological State: Cancer

Results 501 - 510 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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