Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Read the Publication
Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

Read the Publication
AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Read the Publication
Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

Read the Publication
COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Read the Publication
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Read the Publication
Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Read the Publication
Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Read the Publication
Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Read the Publication
Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Read the Publication
Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

Read the Publication
SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Read the Publication
CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Read the Publication
previous arrow
next arrow

Filter publications

Customer Publications (A total of 3421 papers published)

Results 411 - 420 of 3421
411
Immune escape between endoplasmic reticulum stress-related cancer cells and exhausted CD8+T cells leads to neoadjuvant chemotherapy resistance in ovarian cancer

S Zhang, Y Zhang, X Song, X Wang, L Quan, P Xu, W Song, Q Liu, X Zhou

Biochemical and Biophysical Research Communications (Elsevier) China , 14 September 2024

Oncology

Key words: Neoadjuvant chemotherapy, Endoplasmic reticulum stress, Ovarian cancer cell, Exhausted CD8+T cell, Immune escape

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

412
Advanced Electrospun Composites Based on Polycaprolactone Fibers Loaded with Micronized Tungsten Powders for Radiation Shielding

C Giuliani, I De Stefano, M Mancuso, N Fiaschini, LA Hein, DM Gattia, E Scatena, E Zenobi, CD Gaudio, F Galante, G Felici, A Rinaldi

Polymers (MDPI) Italy , 13 September 2024

Biomaterials

Key words: shielding; polycaprolactone (PCL); tungsten powder; polymer composites; electrospinning; radiation protection; aerospace; healthcare industry

Organism: Mouse

Tissue: Brain

Pathological State: Radiation

413
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy

JG Baldwin, CL Heuser-Loy, T Saha, RC Schelker, DL Slavkovic-Lukic, N Strieder, IL Hernandez-Lopez, N Rana, M Barden, F Mastrogiovanni, AS Martín-Santos, A Raimondi, P Brohawn, BW Higgs, C Gebhard, V Kapoor, WG Telford, S Gautam, M Xydia, P Beckhove, S Frischholz, K Schober, Z Kontarakis, JE Corn, M Iannacone, D Inverso, M Rehli, J Fioravanti, S Sengupta, L Gattinoni

Cell (Cell) Germany, USA, Italy, Switzerland , 13 September 2024

Immunology

Key words: mitochondrial transfer, CD8+T celss, nanotubes, cancer immunotherapy, bone marrow stromal cells, Talin 2, CAR T therapy, TCR-T therapy, TIL therapy immune metabolism

Organism: Mouse

Tissue: Bone Marrow

414
Combined use of CLP290 and bumetanide alleviates neuropathic pain and its mechanism after spinal cord injury in rats

Y Pan, Z Talifu, X Wang, H Ke, C Zhang, X Xu, DG Yang, Y Yu, LJ Du, F Gao, JJ Li

CNS Neuroscience & Therapeutics (Wiley Online Library) China , 12 September 2024

Neuroscience

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

415
滞动针干预 “激痛点” 对肌筋膜疼痛综合征模型大鼠中枢镇痛的作用机制

Z Liping, C Yifei, W Yaqian, L Thitong, T Qi, G Bo

Chinese Journal of Tissue Engineering Research (Journal of Clinical Rehabilitative Tissue Engineering Research) China , 12 September 2024

Neuroscience

Key words: myofascial pain syndrome, myofascial trigger points, stagnant moving needle, central analgesia, brain-derived neurotrophic factor, periaqueductal gray

Organism: Rat

Tissue: Muscle

Pathological State: Inflammation

416
Genome-wide characterization of dynamic DNA 5-hydroxymethylcytosine and TET2-related DNA demethylation during breast tumorigenesis

SL Wu, L Yang, C Huang, Q Li, C Ma, F Yuan, Y Zhou, X Wang, WM Tong, Y Niu, F Jin

Clinical Epigenetics (BMC) China , 11 September 2024

Oncology

Key words: Breast tumorigenesis, DNA 5-hydroxymethylcytosine, 5-methylcytosine, DNA methylation, NA demethylation, TET2, cfDNA

Organism: Human

Tissue: Breast

Pathological State: Cancer

417
Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis

J Li, S Zhang, C Li, X Zhang, Y Shan, Z Zhang, H Bo, Y Zhang

Scientific Reports (Nature) China , 10 September 2024

Physiology

Key words: Skeletal muscle fiber type, Mitochondrial biogenesis, Endurance exercise, Histone methylation, ROS, AMPK, Molecular bioloy, Physiology

Organism: Rat

Tissue: Muscle

Pathological State: Tissue

418
Integrated MRI radiomics, tumor microenvironment, and clinical risk factors for improving survival prediction in patients with glioblastomas

Q Zhou, X Ke, J Man, J Jiang, J Ren, C Xue, B Zhang, P Zhang, J Zhao, J Zhou

Strahlentherapie und Onkologie (Springer) China , 09 September 2024

Oncology

Key words: Glioblastoma, Tumor microenvironment, Prognosis, Radiomics, Prediction model

Organism: Human

Tissue: Brain

Pathological State: Cancer

419
Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer

CH Hung, SY Wu, CID Yao, HH Yeh, CC Lin, CY Chu, TY Huang, MR Shen, CH Lin, WC Su

Nature Communications (Nature) Taiwan , 09 September 2024

Oncology

Key words: Cancer therapeutic resistance, Glycobiology, Non-small-cell lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

420
Integration and competition between space and time in the hippocampus

S Chen, N Cheng, X Chen, C Wang

Neuron (Cell Press) China , 05 September 2024

Neuroscience

Key words: place cell, time cell, navigation, spatiotemporal, episodic memory

Organism: Mouse

Tissue: Brain

Results 411 - 420 of 3421

LogoOrangewhite2025

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact us

About Us

TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

Keep in Touch

Be the first to hear about the latest scientific updates