Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 3071 - 3080 of 3476
3071
Localized Hyperthermia with Iron Oxide–Doped Yttrium Microparticles: Steps toward Image-Guided Thermoradiotherapy in Liver Cancer

Andrew C Gordon, Robert J Lewandowski, Riad Salem, Delbert E Day, Reed A Omary, Andrew C Larson

Journal of Vascular and Interventional Radiology (Elsevier) USA , 06 December 2013

Oncology

Key words: Hepatocellular carcinoma, normal hepatic parenchyma, alternating magnetic field

Organism: Rat

Tissue: Liver

Pathological State: Cancer

3072
MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation

Stefania Puttini, Ruthger W van Zwieten, Damien Saugy, Malgorzata Lekka, Florence Hogger, Deborah Ley, Andrzej J Kulik, Nicolas Mermod

BMC Molecular Biology (Springer) Switzerland, Poland , 02 December 2013

Genetics

Key words: Inducible expression, non-viral vectors, MAR elements, erythropoietin, utrophin, gene therapy

Organism: Mouse

Tissue: Muscle

3073
Transdifferentiation of Adipose-Derived Stem Cells into Keratinocyte-Like Cells: Engineering a Stratified Epidermis

Claudia Chavez-Munoz, Khang T Nguyen,Wei Xu, Seok-Jong Hong,Thomas A Mustoe, Robert D Galiano

PLoS One (PLOS) USA , 02 December 2013

Stem Cell Research

Key words: Keratinocytes, cell staining, transdifferentiation, cell differentiation, mesenchymal stem cells, DAPI staining, antibiotics, fibroblasts

Organism: Human

Cell Line: Adipose-Derived Stem Cells

3074
Targeting SOD1 reduces experimental non–small-cell lung cancer

Andrea Glasauer, Laura A Sena, Lauren P Diebold, Andrew P Mazar, and Navdeep S Chandel

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA , 02 December 2013

Oncology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

3075
Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial–mesenchymal transition ZEB1/2

Sabine Konradi, Nighat Yasmin1, Denise Haslwanter, Michele Weber, Bernhard Gesslbauer, Michael Sixt, Herbert Strobl

European Journal of Immunology (Wiley) Austria , 02 December 2013

Immunology

Key words: Cell migration, dendritic cells, epithelial-to-mesenchymal transition, langerhans cells, maturation

Organism: Human

Cell Line: Langerhans cells

3076
A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog

Astrid Hagelkruys, Sabine Lagger, Julia Krahmer, Alexandra Leopoldi, Matthias Artaker, Oliver Pusch, Jürgen Zezua, Simon Weissmann, Yunli Xie, Christian Schöfer, Michaela Schlederer, Gerald Brosch, Patrick Matthias, Jim Selfridge, Hans Lassmann, Jürgen A Knoblich, Christian Seiser

Development (The Company of Biologists) Austria, Switzerland, UK , 19 November 2013

Neuroscience

Key words: Histone deacetylases, neural cells, histone acetyltransferases, central nervous system

Organism: Mouse

Tissue: Brain

3077
Developmental and oncogenic radiation effects on neural stem cells and their differentiating progeny in mouse cerebellum

Mirella Tanori, Emanuela Pasquali, Simona Leonardi, Arianna Casciati, Paola Giardullo, Ilaria De Stefano, Mariateresa Mancuso, Anna Saran, Simonetta Pazzaglia

Stem Cells (Wiley) Italy , 15 November 2013

Stem Cell Research

Key words: Ptc1+/- mice, apoptosis, DNA repair, p21, medulloblastoma, carcinogenesis, neural stem cells, progenitor cells

Organism: Mouse

Tissue: Brain

3078
Epidermal Growth Factor Receptor Targeted Nuclear Delivery and High-Resolution Whole Cell X-ray Imaging of Fe3O4@TiO2 Nanoparticles in Cancer Cells

Ye Yuan, Si Chen, Tatjana Paunesku, Sophie Charlotte Gleber, William C Liu, Caroline B Doty, Rachel Mak, Junjing Deng, Qiaoling Jin, Barry Lai, Keith Brister, Claus Flachenecker, Chris Jacobsen, Stefan Vogt, Gayle E Woloschak

ACS NANO (ACS Publications) USA , 12 November 2013

Imaging

Key words: Nanoparticles, titanium dioxide, photoactivation, X-ray fluorescence microscopy, epidermal growth factor receptor

Organism: Human

Cell Line: HeLa cells

3079
Cardiac magnetic resonance postcontrast T1 time is associated with outcome in patients with heart failure and preserved ejection fraction

Mascherbauer J, Marzluf BA, Tufaro C, Pfaffenberger S, Graf A, Wexberg P, Panzenböck A, Jakowitsch J, Bangert C, Laimer D, Schreiber C, Karakus G, Hülsmann M, Pacher R, Lang IM, Maurer G, Bonderman D

Circulation:Cardiovascular Imaging (AHA Journals) Austria, Turkey , 06 November 2013

Cardiology

Key words: Hypertension, pulmonary, magnetic resonance imaging, prognosis

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

3080
Hypercapnia Impairs Lung Neutrophil Function and Increases Mortality in Murine Pseudomonas Pneumonia

Khalilah L Gates, Heather A Howell, Aisha Nair, Christine U Vohwinkel, Lynn C Welch, Greg J Beitel, Alan R Hauser, Jacob I Sznajder, and Peter H S Sporn

American Journal of Respiratory Cell and Molecular Biology (ATS Journals) USA , 01 November 2013

Pulmonology

Key words: arbon dioxide, pulmonary infection, reactive oxygen species, phagocytosis, inflammation

Organism: Mouse

Tissue: Lung

Pathological State: Pseudomonas Infection, Pneumonia

Results 3071 - 3080 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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