Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 3051 - 3060 of 3476
3051
Successful treatment of adult onset Langerhans cell histiocytosis with bi-weekly administration of pegylated interferon-α

Sadanori Furudate, Taku Fujimura, Yumi Kambayashi, Mitsuko Kawano, Kouetsu Ogasawara, Akira Tsukada, Erika Tamabuchi, Takahiro Haga, Akira Hashimoto and Setsuya Aiba

Acta Dermato Venereologica (Ingentaconnect) Japan , 04 February 2014

Dermatology

Organism: Human

Tissue: Skin

Pathological State: Histiocytosis

3052
Serum Level of IL-10 Is Increased in Patients with Endometriosis, and IL-10 Promotes the Growth of Lesions in a Murine Model

Jau-Ling Suen, Yu Chang, Pu-Rong Chiu, Tsung-Hua Hsieh, Edward Hsi, Yu-Chieh Chen, Yu-Fang Chen, Eing-Mei Tsai

The American Journal of Pathology (American Society for Investigative Pathology) Taiwan , 01 February 2014

Pathology

Key words: Immune dysregulation, anti-inflammatory cytokine IL-10, Monocyte-derived dendritic cells

Organism: Mouse

Tissue: Uterus

Pathological State: Endometriosis

3053
Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

Ummuhan Demir, Andrea Koehler, Rainer Schneider, Susann Schweiger, Helmut Klocker

BMC Cancer (Springer) Austria, Germany , 31 January 2014

Oncology

Key words: Metformin, Androgen receptor, MID1-α4/PP2A protein complex, AMPK, Translational regulation, CoIP

Organism: Human

Cell Line: LNCaP, Du-145, VCaP and PC-3 cells

3054
Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling

BS Moon, WJ Jeong, J Park, TI Kim, DS Min, KY Choi

Journal of the National Cancer Institute (Oxford University Press) South Korea , 31 January 2014

Oncology

Key words: signal transduction, mutation, cd44 antigens, transplantation, heterologous, mice, neoplasms, k-ras oncogene, homing-associated cell adhesion molecule, cancer stem cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

3055
Die prognostische Bedeutung von Tumor-infiltrierenden CD8+Zellen: eine detaillierte Analyse in Hinblick auf Tumor-Debulking und Zell-Proliferation

S Aust, A Bachmayr-Heyda, S Polterauer, D Pils, DC Castillo-Tong, OVCAD Consortium

Geburtshilfe und Frauenheilkunde (Thieme) Austria , 30 January 2014

Immunology

3056
The role of the organic anion transporting polypeptide OATP4A1 in immunactivation in colorectal cancer and inflammatory colon disease.

Christoph Alexander Ausch, Simone Zotter, Maidah Scheikh, Heike Bauer, Marina Mollik, Erika Bajna, Christian Sebesta, Angelika Reiner, Theresia Thalhammer and Veronika Buxhofer-Ausch

Journal of Clinical Oncology (American Society of Clinical Oncology) , 20 January 2014

Oncology

Key words: Prostaglandins, cyclic nucleotides, second messenger proteins, tumor cells growth

3057
A dual role for autophagy in a murine model of lung cancer

Shuan Rao, Luigi Tortola, Thomas Perlot, Gerald Wirnsberger, Maria Novatchkova, Roberto Nitsch, Peter Sykacek, Lukas Frank, Daniel Schramek, Vukoslav Komnenovic, Verena Sigl, Karin Aumayr, Gerald Schmauss, Nicole Fellner, Stephan Handschuh, Martin Glösmann, Pawel Pasierbek, Michaela Schlederer, Guenter P Resch, Yuting Ma, Heng Yang, Helmuth Popper, Lukas Kenner, Guido Kroemer and Josef M Penninger

Nature Communications (Nature) Austria, France , 20 January 2014

Oncology

Key words: Autophagy, Lung cancer, Oncogenesis

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

3058
Glycogen Synthase Kinase 3β (GSK3β) Regulates Differentiation and Proliferation in Neural Stem Cells from the Rat Subventricular Zone 1

Martin H Maurer, Jens O Brömme, Robert E Feldmann, Jr Anne Järve, Fatemeh Sabouri, Heinrich F Bürgers, Dominik W Schelshorn, Carola Krüger, Armin Schneider, Wolfgang Kuschinsky

Journal of Proteome Research (ACS Publications) Germany , 18 January 2014

Stem Cell Research

Key words: Neural stem cell, Neurosphere, Glycogen Synthase Kinase 3β, Two-dimensional gel electrophoresis, Rat, Subventricular zone

Organism: Rat

Tissue: Brain

3059
NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice

Keiichi Shirasaki, Keiko Taguchi, Michiaki Unno, Hozumi Motohashi, Masayuki Yamamoto

Hepatology (Wiley) Japan , 17 January 2014

Hepathology

Key words: Hepatectomy, portal vein embolization, phosphoinositide 3-kinase, protein kinase B (PI3K/Akt) pathway

Organism: Mouse

Tissue: Liver

3060
Hepatic RIG-I Predicts Survival and Interferon-α Therapeutic Response in Hepatocellular Carcinoma

Jin Hou, Ye Zhou, Yuanyuan Zheng, Jia Fan, Weiping Zhou, Irene OL Ng, Huichuan Sun, Lunxiu Qin, Shuangjian Qiu, Joyce MF Lee, Chung-Mau Lo, Kwan Man, Yuan Yang, Yun Yang, Yingyun Yang, Qian Zhang, Xuhui Zhu, Nan Li, Zhengxin Wang, Guoshan Ding, Shi-Mei Zhuang, Limin Zheng, Xiaoling Luo, Yuan Xie, Anmin Liang, Zhugang Wang, Ming Zhang, Qiang Xia, Tingbo Liang, Yizhi Yu, Xuetao Cao

Cancer Cell (Cell Press) China , 13 January 2014

Oncology

Key words: Hepatocellular carcinoma, interferon-α, retinoic acid-inducible gene-I

Organism: Human

Tissue: Liver

Pathological State: Cancer

Results 3051 - 3060 of 3476

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