Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 3041 - 3050 of 3421
3041
Comparison of Interleukin-17- Producing Cells in Different Clinical Types of Alopecia Areata

Tojo G, Fujimura T, Kawano M, Ogasawara K, Kambayashi Y,Furudate S, Mizuashi M, Aiba S

Dermatology (Karger) Japan , 01 October 2013

Dermatology

Key words: Alopecia areata Interleukin-17 Interferon Acute, diffuse and total alopecia

Organism: Human

Tissue: Skin

Pathological State: Alopecia Areata

3042
Expression Of CD8 Is Associated With Non-Common Type Morphology And Outcome In Pediatric Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma

Dmitriy Abramov, Ilske Oschlies, Martin Zimmermann, Dmitriy Konovalov, Christine Damm-Welk, Wilhelm Wössmann, Wolfram Klapper

Haematologica (Ferrata Storti Foundation) Germany, Russia , 01 October 2013

Oncology

Key words: Anaplastic lymphoma kinase, CD30-positive T-cell lymphoma, vinblastine, autologous, allogeneic hematopoietic stem cell transplantation

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

3043
Up-Regulation of SOX9 in Sertoli Cells from Testiculopathic Patients Accounts for Increasing Anti-Mullerian Hormone Expression via Impaired Androgen Receptor Signaling

Kuo-Chung Lan, Yen-Ta Chen, Chawnshang Chang, Yung-Chiao Chang, Hsin-Jung Lin, Ko-En Huang, Hong-Yo Kang

PLoS One (PLOS) Taiwan, USA , 01 October 2013

Endocrinology

Key words: Sertoli cells, testes, androgens, spermatogenesis, reverse transcriptase-polymerase chain reaction, testosterone, adults, germ cells

Organism: Human

Tissue: Testis

Pathological State: Sertoli-cell-only syndrome

3044
Digital immunohistochemistry: new horizons and practical solutions in breast cancer pathology

Arvydas Laurinavicius, Justinas Besusparis, Justina Didziapetryte, Gedmante Radziuviene, Raimundas Meskauskas Aida Laurinaviciene

Diagnostic Pathology (BioMed Central) Lithuania , 30 September 2013

Oncology

Key words: Breast cancer, Immunohistochemistry (IHC) biomarkers, tissue microarray

Organism: Human

Tissue: Breast

Pathological State: Cancer

3045
Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells

Stephan Blüml, Martin Friedrich, Tobias Lohmeyer, Emine Sahin, Victoria Saferding, Julia Brunner, Antonia Puchner, Peter Mandl, Birgit Niederreiter, Josef S Smolen, Gernot Schabbauer, Kurt Redlich

Annals of the Rheumatic Diseases (BMJ Journals) Austria , 27 September 2013

Rheumatology

Key words: Rheumatic diseases, osteoclasts, Phosphoinositide-3-Kinase, Phosphatase and tensin homolog

Organism: Mouse

Tissue: Joint Tissue, Bone

3046
Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate

Morizane A, Doi D, Kikuchi T, Okita K, Hotta A, Kawasaki T, Hayashi T, Onoe H, Shiina T, Yamanaka S, Takahashi J

Stem Cell Reports (Cell Press) Japan , 26 September 2013

Transplantation Medicine

Organism: Monkey

Tissue: Brain

3047
Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients - a study of the OVCAD consortium

Anna Bachmayr-Heyda, Stefanie Aust, Georg Heinze, Stephan Polterauer, Christoph Grimm, Elena Ioana Braicu, Jalid Sehouli, Sandrina Lambrechts, Ignace Vergote, Sven Mahner, Dietmar Pils, Eva Schuster, Theresia Thalhammer, Reinhard Horvat, Carsten Denkert, Robert Zeillinger, Dan Cacsire Castillo-Tong

BMC Cancer (BioMed Central) Austria, Germany, Belgium , 17 September 2013

Oncology

Key words: Epithelial ovarian cancer, Cytotoxic T cells, Tumor proliferation, Prognostic impact, Residual tumor

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

3048
A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis

Jimin Shin, Jang Choon Lee, Kwan-Hyuck Baek

Cancer Letters (Elsevier) South Korea , 16 September 2013

Oncology

Key words: Down syndrome, cancer, angiogenesis, Dscr1, Spontaneous lung tumorigenesis

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

3049
Contribution of Toll-Like Receptor 2 to the Innate Response against Staphylococcus aureus Infection in Mice

Yimin, Masashi Kohanawa, Songji Zhao, Michitaka Ozaki,Sanae Haga, Guangxian Nan, Yuji Kuge, Nagara Tamaki

PLoS One (PLOS) Japan, China , 13 September 2013

Immunology

Key words: Staphylococcus aureus, macrophages, cytokines, bacterial pathogens, toll-like receptors, neutrophils, gene expression, blood

Organism: Mouse

Tissue: Liver

Pathological State: Staphylococcus aureus Infection

3050
Comprehensive characterizations of nanoparticle biodistribution following systemic injection in mice

WY Liao, HJ Li, MY Chang, ACL Tang, AS Hoffman, PCH Hsieh

Nanoscale (Royal Society of Chemistry) Taiwan, USA , 06 September 2013

Nanomedicine

Organism: Mouse

Tissue: Brain, Heart, Lung, Liver, Spleen, Kidney, Skin

Results 3041 - 3050 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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