Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 3031 - 3040 of 3476
3031
Protective effect of magnesium and metformin on endometrium and ovary in experimental diabetes mellitus

C Gales, C Zamfir, D Radulescu, B Stoica, M Nechifor

Magnesium research (John Libbey) Romania , 01 April 2014

Reproductive Medicine

Key words: magnesium, endometrium, ovary, diabetes mellitus

Organism: Mouse

Pathological State: Diabetes

Cell Line: Fibroblasts

3032
Muscle–fat MRI: 1.5 tesla and 3.0 tesla versus histology

Andrew C Smith, Todd B Parrish, Rebecca Abbott, Mark A Hoggarth, Karl Mendoza, Yu Fen Chen, James M Elliott

Muscle and nerve (Wiley) USA , 28 March 2014

Imaging

Key words: MRI, muscle fat infiltrates, muscle imaging, muscle/fat fraction, muscle, fat

Organism: Rabbit

Tissue: Muscle

3033
Oxygen therapy does not increase production and damage induced by reactive oxygen species in focal cerebral ischemia

Li Suna, Guido Wolfertsb, Roland Veltkamp

Neuroscience Letters (Elsevier) Germany , 28 March 2014

Neuroscience

Key words: Cerebral ischemia, oxygen therapy, HBO, reactive oxygen species, SOD2

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

3034
Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin-Positive Intradermal Progenitors

Roberta Goncalves Marangoni, Benjamin D Korman, Jun Wei, Tammara A Wood, Lauren V Grham, Michael L Whithfield, Philipp E Scherrr, Warren G Tourtellott, John Varga

Arthritis & Rheumatology (Wiley) USA , 27 March 2014

Rheumatology

Key words: Myofibroblasts, systemic sclerosis, growth factor β, canonical adipogenic markers

Organism: Mouse

Tissue: Skin

Pathological State: Systemic Sclerosis

3035
In vivo real-time fluorescence visualization and brain-targeting mechanisms of lipid nanocarriers with different fatty ester:oil ratios

Chih-Jen Wen, Tzu-Chen Yen, Saleh A Al-Suwayeh, Hui-Wen Chang, Jia-You Fang

Future Medicine (FSG) Taiwan, Saudi Arabia , 27 March 2014

Nanomedicine

Key words: Lipid nanocarriers, cetyl palmitate, squalene, sulforhodamine B

Organism: Rat

Tissue: Brain

3036
RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis

Marion Lapierre, Sandrine Bonnet, Caroline Bascoul-Mollevi, Imade Ait-Arsa, Stéphan Jalaguier, Maguy Del Rio, Michela Plateroti, Paul Roepman, Marc Ychou, Julie Pannequin, Frédéric Hollande, Malcolm Parker, and Vincent Cavailles1

The Journal of Clinical Investigation (American Society for Clinical Investigation) France, The Netherlands, UK , 25 March 2014

Oncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

3037
Ambivalent role of pFAK-Y397 in serous ovarian cancer-a study of the OVCAD consortium

Stefanie Aust, Katharina Auer, Anna Bachmayr-Heyda, Carsten Denkert, Jalid Sehouli, Ioana Braicu, Sven Mahner, Sandrina Lambrechts, Ignace Vergote, Christoph Grimm, Reinhard Horvat, Dan Cacsire Castillo-Tong, Robert Zeillinger Dietmar Pils

Molecular Cancer (Springer) Austria, Germany, Belgium , 21 March 2014

Oncology

Key words: FAK, pFAK, molecular subclassification, immunohistochemistry, prognosis, ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

3038
Protection against Dengue Virus Infection in Mice by Administration of Antibodies against Modified Nonstructural Protein 1

Shu-Wen Wan, Yi-Tien Lu, Chia-Hui Huang, Chiou-Feng Lin, Robert Anderson, Hsiao-Sheng Liu, Trai-Ming Yeh, Yu-Ting Yen, Betty A Wu-Hsieh, Yee-Shin Lin

PLoS One (PLOS) Taiwan, Canada , 21 March 2014

Virology

Key words: Hemorrhage, endothelial cells, platelets, complement system, dengue fever, hematoxylin staining, inoculation, macrophages

Organism: Mouse

Tissue: Skin

Pathological State: Dengue Virus Infection

3039
Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation

T Kuga, H Nie, T Kazami, M Satoh, K Matsushita, F Nomura, K Maeshima, Y Nakayama and T Tomonaga

Oncogenesis (Nature) Japan , 17 March 2014

Oncology

Key words: Chromosome segregation, Colorectal cancer, Mitotic spindle

Organism: Human

Tissue: Colon

Pathological State: Cancer

3040
Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

Veronica T Campbell, Puviindran Nadesan, S Amanda Ali, Chang Ye Yale Wang, Heather Whetstone, Raymond Poon, Qingxia Wei, John Keilty, Jennifer Proctor, Lauren W Wang, Suneel S Apte, Karen McGovern, Benjamin A Alman, Jay S Wunder

Molecular Cancer Therapeutics (AACR Publications) USA, Canada , 14 March 2014

Oncology

Key words: Hedgehog (Hh) pathway, Chondrosarcoma, transmembrane receptor Patched

Organism: Mouse

Tissue: Xenograft Tumor, Joint Tissue

Pathological State: Cancer

Results 3031 - 3040 of 3476

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