Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

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Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 3011 - 3020 of 3421
3011
Lymph node status assessed through the log odds ratio–a better tool in the prognosis of colorectal cancer relapse

ST Makkai-Popa, S Luncă, E Târcoveanu, E Carasevici, G Dimofte

Romanian Journal of Morphology and Embryology () Romania , 01 January 2014

Oncology

Key words: disease-free interval, lymph node ratio, log odds ratio.

3012
HISTOQUEST–MODALITY OF MICROANATOMICAL ANALYSIS OF THE IMMUNOHISTOCHEMICAL COLORATION IN BREAST CANCER AND DATA …

Vrânceanu, Anca, Tărniceriu, Claudia Cristina, Makkai, S, Carasevici, E

Romanian Journal of Functional & Clinical, Macro- & Microscopical Anatomy & of Anthropology (EBSCO) Romania , 01 January 2014

Oncology

3013
Role of endocytic uptake in transfection efficiency of solid lipid nanoparticles-based nonviral vectors

Aritz Perez Ruiz de Garibay, María Ángeles Solinís Aspiazu, Alicia Rodríguez Gascón, Haleh Ganjian, Renate Fuchs

Journal of Gene Medicine (Wiley) Spain, Austria , 27 December 2013

Nanomedicine

Key words: Endocytosis, lysosome, nonviral vector, solid lipid nanoparticles, transfection

Organism: Human

Cell Line: HeLa cells

3014
Ginsenoside Rg3 Up-regulates the Expression of Vascular Endothelial Growth Factor in Human Dermal Papilla Cells and Mouse Hair Follicles

Dae Hyun Shin, Youn Jeong Cha, Kyeong Eun Yang, Ik-Soon Jang, Chang-Gue Son, Bo Hyeon Kim, Jung Min Kim

Phytotherapy Research (Wiley) South Korea , 26 December 2013

Dermatology

Key words: Rg3, hair growth, DP cell, gene expression profiles, VEGF, stemness marker

Organism: Human

Cell Line: Dermal Papilla cells

3015
Application of quinidine on rat sciatic nerve decreases the amplitude and increases the latency of evoked responses

Kuang-I Cheng, I-Ling Lin, Lin-Li Chang, I-Ming Jou, Chung-Sheng Lai, Jhi-Joung Wang, Hung-Chen Wang, Aij-Lie Kwan

Journal of Anesthesia (Springer) Taiwan , 15 December 2013

Neuroscience

Key words: Sciatic nerve, lidocaine, sciatic nerve fiber, contralateral hind limb, rat sciatic nerve, quinidine concentration, sodium channel, ranvier node, myelinated nerve fiber, local anesthetic, nerve conduction, peripheral nerve, neuropathic pain, conduction velocity

Organism: Rat

Tissue: Brain

3016
Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224

Sheng-Hui Lan, Shan-Ying Wu, Roberto Zuchini, Xi-Zhang Lin, Ih-Jen Su, Ting-Fen Tsai, Yen-Ju Lin, Cheng-Tao Wu and Hsiao-Sheng Liu

Hepatology (Wiley) Taiwan , 13 December 2013

Oncology

Key words: microRNA-224, miR‐224 antagonist, autophagosome fraction, autophagy‐related genes, chloroquine, double distilled water, digoxigenin, hepatitis B virus, hepatitis B virus X protein, hepatocellular carcinoma, hepatitis C virus

Organism: Human

Tissue: Liver

Pathological State: Cancer

3017
Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation

Tsung-Ming Chen, Yu-Heng Shih, Joseph T Tseng, Ming-Chih Lai, Chih-Hao Wu, Yi-Han Li, Shaw-Jenq Tsai, H Sunny Sun

Nucleic Acids Research (Oxford University Press) Taiwan , 10 December 2013

Oncology

Key words: Human fibroblast growth factor 9, hypoxia, colon cancer cells

Organism: Human

Tissue: Colon

Pathological State: Cancer

3018
Localized Hyperthermia with Iron Oxide–Doped Yttrium Microparticles: Steps toward Image-Guided Thermoradiotherapy in Liver Cancer

Andrew C Gordon, Robert J Lewandowski, Riad Salem, Delbert E Day, Reed A Omary, Andrew C Larson

Journal of Vascular and Interventional Radiology (Elsevier) USA , 06 December 2013

Oncology

Key words: Hepatocellular carcinoma, normal hepatic parenchyma, alternating magnetic field

Organism: Rat

Tissue: Liver

Pathological State: Cancer

3019
MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation

Stefania Puttini, Ruthger W van Zwieten, Damien Saugy, Malgorzata Lekka, Florence Hogger, Deborah Ley, Andrzej J Kulik, Nicolas Mermod

BMC Molecular Biology (Springer) Switzerland, Poland , 02 December 2013

Genetics

Key words: Inducible expression, non-viral vectors, MAR elements, erythropoietin, utrophin, gene therapy

Organism: Mouse

Tissue: Muscle

3020
Transdifferentiation of Adipose-Derived Stem Cells into Keratinocyte-Like Cells: Engineering a Stratified Epidermis

Claudia Chavez-Munoz, Khang T Nguyen,Wei Xu, Seok-Jong Hong,Thomas A Mustoe, Robert D Galiano

PLoS One (PLOS) USA , 02 December 2013

Stem Cell Research

Key words: Keratinocytes, cell staining, transdifferentiation, cell differentiation, mesenchymal stem cells, DAPI staining, antibiotics, fibroblasts

Organism: Human

Cell Line: Adipose-Derived Stem Cells

Results 3011 - 3020 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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