Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2991 - 3000 of 3476
2991
Analysis of tumour-and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

Lisa Sevenich, Robert L Bowman, Steven D Mason, Daniela F Quail, Franck Rapaport, Benelita T Elie, Edi Brogi, Priscilla K Brastianos, William C Hahn, Leslie J Holsinger, Joan Massagué, Christina S Leslie and Johanna A Joyce

Nature Cell Biology (Nature) USA , 03 August 2014

Oncology

Key words: Cancer microenvironment, Metastasis

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

2992
Benzyl butyl phthalate induces migration, invasion, and angiogenesis of Huh7 hepatocellular carcinoma cells through nongenomic AhR/G-protein signaling

Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Feng-Jie Lai, Kung-Kai Kuo, Hua-Lin Wu, Eing-Mei Tsai and Po-Lin Kuo

BMC Cancer (Springer) Taiwan , 01 August 2014

Oncology

Key words: Phthalate, Aryl hydrocarbon receptor, Angiogenesis, Migration, Hepatocellular carcinoma

Organism: Mouse

Tissue: Liver, Xenograft Tumor

Pathological State: Cancer

2993
The vitamin D system is deregulated in pancreatic diseases

Doris Hummel, Abhishek Aggarwal, Katalin Borka, Erika Bajna, Enikö Kállay, Henrik Csaba Horváth

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, Hungary, Switzerland , 30 July 2014

Oncology

Key words: Vitamin D, CYP24A1, VDR, CaSR, chronic pancreatitis, pancreatic ductal adenocarcinoma, pancreatic cancer

Organism: Human

Tissue: Pancreas

2994
Hardware and Software

Yves Sucaet, Wim Waelput

Hardware and Software (Springer) Belgium , 23 July 2014

Imaging

Key words: Digital pathology, slide scanner, tile scanner, line scanner, file format, medical imaging WSI DP MRXS NDPI SVS BIF

2995
Single Administration of p2TA (AB103), a CD28 Antagonist Peptide, Prevents Inflammatory and Thrombotic Reactions and Protects against Gastrointestinal Injury in Total-Body Irradiated Mice

Salida Mirzoeva, Tatjana Paunesku, M Beau Wanzer, Anat Shirvan, Raymond Kaempfer, Gayle E Woloschak, William Small Jr

PLoS One (PLOS) USA, Israel , 23 July 2014

Gastroenterology

Key words: Inflammation, ayclins, fibrinogen, macrophages, gamma rays, cytokines, infrared radiation, small intestine

Organism: Mouse

Tissue: Intestine, Lung, Spleen

2996
Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification

Tanja Niedermaira, Volker Kuhn, Fatemeh Doranehgard, Richard Stange, Britta Wieskötter, Johannes Beckmann, Philipp Salmen, Hans-Robert Springorum, Rainer H Straub, Andreas Zimmer, Joachim Grifka, Susanne Grässel

Matrix Biology (Elsevier) Germany, Austria , 22 July 2014

Neuroscience

Key words: Substance P, sympathetic nerve fibers, fracture callus, bone structure, bone formation, bone resorption, biomechanics, endochondral ossification

Organism: Mouse

Tissue: Bone Marrow

2997
Wnt Coreceptor Lrp5 Is a Driver of Idiopathic Pulmonary Fibrosis

Anna P Lam, Jose D Herazo-Maya, Joseph A Sennello, Annette S Flozak, Susan Russell, Gökhan M Mutlu, G R Scott Budinger, Ramanuj DasGupta, John Varga, Naftali Kaminski, and Cara J Gottardi

American Journal of Respiratory and Critical Care Medicine (ATS Journals) USA , 15 July 2014

Pulmonology

Key words: lung fibrosis, Wnt/β-catenin signaling, peripheral blood mononuclear cell

Organism: Human

Tissue: Lung

Pathological State: Pulmonary Fibrosis

2998
Reliable Quantification of Protein Expression and Cellular Localization in Histological Sections

Michaela Schlederer, Kristina M Mueller, Johannes Haybaeck, Susanne Heider, Nicole Huttary, Margit Rosner, Markus Hengstschläger, Richard Moriggl, Helmut Dolznig, Lukas Kenner

PLoS One (PLOS) Austria , 11 July 2014

Pathology

Key words: Image analysis, pathologists, cell staining, hepatocytes, protein expression, cytoplasmic staining, transcription factors, hepatocellular carcinoma

Organism: Mouse

2999
EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205

P Massoner, T Thomm, B Mack, G Untergasser, A Martowicz, K Bobowski, H Klocker, O Gires and M Puhr

British Journal of Cancer (Nature) Austria, Germany , 03 July 2014

Oncology

Key words: Biomarkers, Cancer therapeutic resistance, Oncogenesis, Prostate cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

3000
Alteration in the Wnt microenvironment directly regulates molecular events leading to pulmonary senescence

Tamas Kovacs, Veronika Csongei, Diana Feller, David Ernszt, Gabor Smuk, Veronika Sarosi, Laszlo Jakab, Krisztian Kvell, Domokos Bartis Judit E Pongracz

Aging Cell (Wiley) Hungary, UK , 01 July 2014

Cell Biology

Key words: Molecular biology of aging, pulmonary senescence, Wnt microenvironment

Organism: Human

Tissue: Lung

Results 2991 - 3000 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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