Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 2961 - 2970 of 3421
2961
Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage

Shin-Shiou Lin, Bing-Hsiean Tzeng,Kuan-Rong Lee, Richard J H Smith, Kevin P Campbell, Chien-Chang Chen

PNAS (PNAS) Taiwan, USA , 13 May 2014

Physiology

Key words: Chondrogenesis, tracheal cartilage, mesenchymal cells, chondrocytes

Organism: Mouse

Tissue: Lung

2962
Cell cycle association and hypoxia regulation of excision repair cross complementation group 1 protein (ERCC1) in tumor cells of head and neck cancer

József Dudás, Volker H Schartinger, Angela Romani, Gabriele Schweigl, Kristian Kordsmeyer, Patricia Irina Marta, Christoph Url, Florian Kral, Herbert Riechelmann

Tumor Biology (Springer) Austria , 12 May 2014

Oncology

Key words: Gene expression, cell cycle phase, bronchial epithelial cell, nuclear extract

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

2963
Relevance of estrogen activating STS and inactivating SULT1E1 enzymes and estrogen receptors [alpha/beta] in patients with advanced ovarian cancer

Felicitas Mungenast, Stefanie Aust, Martin Svoboda, Katharina Ocko, Lukas Klameth, Dan Cacsire Castilo-Tong, Robert Zeillinger, Toon Van Gorp, Ignace Vergote, Ioana Braicu, Jalid Sehouli, Sven Mahner, M Fogel and Theresia Thalhammer

16th European Congress of Endocrinology (Endocrine Abstracts) Austria, Belgium, Germany, Israel , 07 May 2014

Oncology

2964
A new rat model for orthotopic abdominal wall allotransplantation

WW Lao, YL Wang, AE Ramirez, HY Cheng, FC Wie

Plastic Reconstruction Surgery Global open (NCBI) Taiwan , 07 May 2014

Oncology

Organism: Rat

Tissue: Muscle

Pathological State: Allogeneic Transplantation

2965
1172 (pp34) myocardial Biopsy for the Validation of Cardiac Magnetic Resonance T1 Mapping for Quantification of Extracellular Matrix

A Kammerlander, C Tufaro, S Pfaffenberger, B Marzluf, S Aschauer, J Babayev, D Bonderman, J Mascherbauer

European Heart Journal (Oxford University Press) Austria , 01 May 2014

Cardiology

Organism: Human

Tissue: Heart

2966
Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer's Disease

Shao-Ming Wang, Yi-Chao Lee, Chiung-Yuan Ko, Ming-Derg Lai, Ding-Yen Lin, Ping-Chieh Pao, Jhih-Ying Chi, Yu-Wei Hsiao, Tsung-Lin Liu, Ju-Ming Wang

Molecular Neurobiology (Springer) Taiwan , 01 May 2014

Neuroscience

Key words: Alzheimer's disease CEBPD ZNF179, astrocytes, antiapoptosis

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

2967
PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors

Rieko Ohki, Kozue Saito, Yu Chen, Tatsuya Kawase, Nobuyoshi Hiraoka, Raira Saigawa, Maiko Minegishi, Yukie Aita, Goichi Yanai, Hiroko Shimizu, Shinichi Yachida, Naoaki Sakata, Ryuichiro Doi, Tomoo Kosugi, Kazuaki Shimada, Benjamin Tycko, Toshihiko Tsukada, Yae Kanai, Shoichiro Sumi, Hideo Namiki, Yoichi Taya, Tatsuhiro Shibata, Hitoshi Nakagama

PNAS (PNAS) Japan , 01 May 2014

Oncology

Key words: p53 PH domain everolimus p53 target gene mTOR

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

2968
A new fluorescence/PET probe for intracellular human telomerase reverse transcriptase (hTERT) using Tat peptide-conjugated antibody

Kyung Oh Jung, Hyewon Youn, Mi Jeong Kim, Keon Wook Kang, Dong Soo Lee and June-Key Chung

The Journal of Nuclear Medicine () South Korea , 01 May 2014

Biological Methods

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2969
ISAC XXII International Congress

ISAC XXII International Congress

Cytometry Part A (Wiley) , 21 April 2014

Cytometry

2970
Direct comparison of the dynamics of IL-25- and ‘allergen'-induced airways inflammation, remodelling and hypersensitivity in a murine asthma model

X J Yao, K W Huang, Y Li, Q Zhang, J J Wang, W Wang, J Liu, Z Lv, Y Q An, Y Z Ding, C J Corrigan, W Wang, Y C Sun, S Ying

Clinical and Experimental Allergy (Wiley) China, UK , 16 April 2014

Allergy Research

Key words: Asthma, IL-25, IL-25 receptor, murine model, pathogenesis, remodelling

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis, Asthma

Results 2961 - 2970 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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